﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Potocká, E
   Mastihubová, M
   Mastihuba, V
AF Potocka, Elena
   Mastihubova, Maria
   Mastihuba, Vladimir
TI Enzymatic synthesis of tyrosol glycosides
SO JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
LA English
DT Article
DE Tyrosol glycosides; Salidroside; Enzymatic transglycosylation
ID BETA-D-FRUCTOFURANOSIDES; APPLE SEED MEAL; SALIDROSIDE; GLUCOSIDASE;
   PURIFICATION; ALCOHOLS; ANALOGS; INJURY; CELLS; RATS
AB For the purpose of synthesis of tyrosol beta-D-glucopyranoside (salidroside) and its beta-D- and alpha-D-galactopyranoside analogues, transglycosylation of tyrosol with fungal glycosidases (from Aspergillus niger and Aspergillus oryzae) was executed. Cellobiose, lactose and melibiose served as glycosyl donor giving 6.7% yield of salidroside, 10.9% of tyrosol beta-D-galactopyranoside, and 32.2% of alpha-D-galactopyranoside. The glycosylations proceeded on the primary hydroxyl of the tyrosol. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Potocka, Elena; Mastihubova, Maria; Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, SK-84537 Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Institute of Chemistry, SAS
RP Mastihuba, V (corresponding author), Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84537 Bratislava, Slovakia.
EM chemvrma@savba.sk
RI Karnišová Potocká, Elena/AAU-9718-2021; Mastihuba, Vladimír/S-7938-2017;
   Mastihubova, Maria/OZG-0746-2025
OI Karnišová Potocká, Elena/0000-0003-1546-4134; Mastihuba,
   Vladimír/0000-0003-2587-2553; Mastihubova, Maria/0000-0003-3033-811X
FU Slovak Research and Development Agency [APVV-846-12]; Slovak Grant
   Agency for Science VEGA [2/0138/12]; Research & Development Operational
   Programme - ERDF
FX This work was supported by the Slovak Research and Development Agency
   under the contract No. APVV-846-12. This publication is also the result
   of the grant from the Slovak Grant Agency for Science VEGA under the
   Project No. 2/0138/12 and of the projects implementation 'Centre of
   Excellence on Green Chemistry Methods and Processes (CEGreenI)' and
   'Amplification of the Centre of Excellence on Green Chemistry Methods
   and Processes (CEGreenII)' supported by the Research & Development
   Operational Programme funded by the ERDF.
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NR 27
TC 31
Z9 34
U1 3
U2 69
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1381-1177
EI 1873-3158
J9 J MOL CATAL B-ENZYM
JI J. Mol. Catal. B-Enzym.
PD MAR
PY 2015
VL 113
BP 23
EP 28
DI 10.1016/j.molcatb.2014.12.017
PG 6
WC Biochemistry & Molecular Biology; Chemistry, Physical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA CD1MW
UT WOS:000350840000004
DA 2026-05-27
ER

PT J
AU Olennikov, DN
   Chirikova, NK
AF Olennikov, D. N.
   Chirikova, N. K.
TI New Metabolites of Rhodiola rosea. III. Glycosides of
   Hydroquinone, Tyrosol, and Rosiridol
SO CHEMISTRY OF NATURAL COMPOUNDS
LA English
DT Article
DE Rhodiola rosea; Crassulaceae; hydroquinone; tyrosol; rosiridol
ID UNDERGROUND PART; (-)-ROSIRIDOL; CONSTITUENTS
AB The water-soluble part of the EtOH extract of Rhodiola rosea L. [Sedum roseum (L.) Scop., Crassulaceae] contained 15 compounds including six new glycosides 1-6. UV and NMR spectroscopic and mass spectrometric data and chemical transformations determined the structures of the new compounds as hydroquinone 1-O-(6 '-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside (rhodirosin I, 1), hydroquinone 1-O-(6 '-O-alpha-Larabinofuranosyl)-beta-D-glucopyranoside (rhodirosin J, 2), tyrosol 1-O-(6 '-O-alpha-L-arabinofuranosyl)-beta-Dglucopyranoside (rhodirosin K, 3), tyrosol 1-O-(2 '-O-acetyl)-beta-D-glucopyranoside (rhodirosin L, 4), tyrosol 1-O-(2 ',6 '-di-O-acetyl)-beta-D-glucopyranoside (rhodirosin M, 5), and rosiridol 1-O-(2 ',6 '-di-O-acetyl)-beta-D-glucopyranoside (rhodirosin N, 6).
C1 [Olennikov, D. N.] Russian Acad Sci, Inst Gen & Expt Biol, Siberian Branch, 6 Sakhyanovoi St, Ulan Ude 670047, Russia.
   [Chirikova, N. K.] MK Ammosov North Eastern Fed Univ, 58 Belinskogo St, Yakutsk 677000, Russia.
C3 Russian Academy of Sciences; North-Eastern Federal University in Yakutsk
RP Olennikov, DN (corresponding author), Russian Acad Sci, Inst Gen & Expt Biol, Siberian Branch, 6 Sakhyanovoi St, Ulan Ude 670047, Russia.
EM olennikovdn@mail.ru; hofnung@mail.ru
RI Chirikova, Nadezhda/D-8241-2016; Olennikov, Daniil/M-2706-2014
FU Ministry of Science and Higher Education of the Russian Federation
   [121030100227-7, FSRG-2023-0027]
FX The research was supported by the Ministry of Science and Higher
   Education of the Russian Federation in the framework of Science Projects
   Nos. 121030100227-7 and FSRG-2023-0027.
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NR 22
TC 1
Z9 1
U1 2
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0009-3130
EI 1573-8388
J9 CHEM NAT COMPD+
JI Chem. Nat. Compd.
PD JUL
PY 2024
VL 60
IS 4
BP 609
EP 614
DI 10.1007/s10600-024-04395-3
EA AUG 2024
PG 6
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA E6C7B
UT WOS:001283327400004
DA 2026-05-27
ER

PT J
AU Kurkin, VA
   Stenyaeva, VV
   Zimenkina, NI
AF Kurkin, V. A.
   Stenyaeva, V. V.
   Zimenkina, N. I.
TI Phenylpropanoids and Phenylethanoids from Leaves of Betula
   verrucosa
SO CHEMISTRY OF NATURAL COMPOUNDS
LA English
DT Article
DE Betula verrucosa; birch leaves; phenylpropanoids; phenylethanoids
AB The new phenylpropanoid p-dihydrocoumaric acid 9-O-beta-D-glucopyranoside, which we called phloretoside, was isolated from leaves of Betula verrucosa Ehrh. Its structure was elucidated using H-1 NMR and C-13 NMR spectra, UV spectroscopy, mass spectrometry, and chemical transformations. p-Dihydrocoumaric acid (phloretic acid) and the phenylethanoids salidroside and p-tyrosol (aglycon of salidroside) were isolated from the total extracted substances.
C1 [Kurkin, V. A.; Stenyaeva, V. V.; Zimenkina, N. I.] Samara State Med Univ, 89 Chapaevskaya St, Samara 443099, Russia.
C3 Samara State Medical University
RP Kurkin, VA (corresponding author), Samara State Med Univ, 89 Chapaevskaya St, Samara 443099, Russia.
EM Kurkinvladimir@yandex.ru
RI Zimenkina, Natalya/JQI-8142-2023; Kurkin, Vladimir/L-7663-2015
CR [Anonymous], 2018, State Pharmacopoeia of the Russian Federation, V4
   Kurkin V.A., 2019, Pharmacognosy: Textbook for Students of Pharmaceutical Universities
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NR 7
TC 1
Z9 2
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0009-3130
EI 1573-8388
J9 CHEM NAT COMPD+
JI Chem. Nat. Compd.
PD JAN
PY 2023
VL 59
IS 1
BP 59
EP 61
DI 10.1007/s10600-023-03917-9
EA FEB 2023
PG 3
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA G8YT7
UT WOS:000941106400003
DA 2026-05-27
ER

PT J
AU Huang, YX
   Wu, YB
   Wu, JG
   Yi, J
   Zhang, QY
   Chen, TQ
   Wu, JZ
AF Huang, Yunxi
   Wu, Yanbin
   Wu, Jianguo
   Yi, Jun
   Zhang, Qiaoyan
   Chen, Tiqiang
   Wu, Jinzhong
TI Chemical Constituents from Ligustrum lucidum Differentially
   Promote Bone Formation and Prevent Oxidative Damage in Osteoblastic
   UMR-106 cells
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE Alkaline phosphatase; Anti-osteoporosis; Ligustrum lucidum; Osteoblast;
   Oxidative stress
ID PEROXIDE-INDUCED DYSFUNCTION; ANTIOXIDANT; FLAVONOIDS; STRESS; EXTRACT;
   OSTEOPOROSIS; DECOCTION; FRUIT
AB Twelve compounds isolated from the fruits of Ligustrum lucidum (FLL), including four phenethanols, three secoiridoids and five flavonoids, viz. tyrosol (1), hydroxytyrosol (2), salidroside (3), acteoside (4), oleuropein (5), specnuzhenide (6), G13 (7), luteolin (8), luteolin-7-O-beta-D-glucopyranoside (9), apigenin (10), apigenin-7-O-beta-D-glucopyranoside (11), and apigenin-7-O-acetyl-beta-D-glucopyranoside (12) were evaluated for their activity on osteoblast viability and differentiation, and the preventive effect on oxidative damage of osteoblastic UMR-106 cells by hydrogen peroxide. Compounds 3, 4, 5, 6, 7, 9, 10, 11 and 12 significantly increased the viability as well as ALP (alkaline phosphatase) activity in UMR-106 cells. Compounds 1, 2, 10 and 11 could protect osteoblasts against H2O2-induced cell injury, and compounds 1, 2, 11, 12 could attenuate H2O2 decreased the level of ALP activity on UMR-106 cells significantly. These results indicated that these compounds, such as phenylethanoids, secoiridoids and flavonoids are principally responsible for the antiosteoporotic effect of FLL.
C1 [Huang, Yunxi; Wu, Yanbin; Wu, Jianguo; Wu, Jinzhong] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350122, Peoples R China.
   [Yi, Jun] Fujian Inst Educ, Dept Chem & Life Sci, Fuzhou 350025, Peoples R China.
   [Zhang, Qiaoyan] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China.
   [Chen, Tiqiang] Fujian Acad Agr Sci, Fuzhou 350013, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Naval Medical
   University; Fujian Academy of Agricultural Sciences
RP Wu, YB (corresponding author), Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350122, Peoples R China.
EM wxsq1@163.com; jinzhongfj@126.com
RI /AAI-7640-2021; Wu, Yanbin/KII-6627-2024
FU Research Foundation of Health Bureau of Fujian Province of China
   [2011-1-39]; Natural Science Foundation of Fujian province of China
   [2011J01214]
FX This work was conducted in Class III Laboratory of Traditional Chinese
   Medicine on Pharmacognosy of State Administration of Traditional Chinese
   Medicine of People's Republic of China and was financially supported by
   the Research Foundation of Health Bureau of Fujian Province of China
   (Grant No. 2011-1-39) and the Natural Science Foundation of Fujian
   province of China (No. 2011J01214).
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NR 26
TC 4
Z9 6
U1 0
U2 12
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PD MAR
PY 2014
VL 33
IS 2
BP 258
EP 265
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AJ8EP
UT WOS:000337935800012
DA 2026-05-27
ER

PT J
AU Cernáková, L
   Haluz, P
   Mastihuba, V
   Kostálová, Z
   Potocká, EK
   Mastihubová, M
AF Cernakova, Lucia
   Haluz, Peter
   Mastihuba, Vladimir
   Kostalova, Zuzana
   Potocka, Elena Karnisova
   Mastihubova, Maria
TI Enzymatic β-Mannosylation of Phenylethanoid Alcohols
SO MOLECULES
LA English
DT Article
DE phenylethanoid glycosides; beta-mannosidase; Novozym 188; tyrosol
   beta-D-mannopyranoside; hydroxytyrosol beta-D-mannopyranoside;
   mannobiose
ID EFFICIENT SYNTHESIS; D-MANNOPYRANOSIDES; D-MANNOSIDES; OLIGOSACCHARIDES;
   GLYCOSYLATION; ALKYL; CONSTRUCTION; GLYCOSIDES; C-13
AB Phenylethanoid glycosides (PhGs) are widely occurring secondary metabolites of medicinal plants with interesting biological activities such as antioxidant, anti-inflammatory, neuroprotective, antiviral, hepatoprotective, immunomodulatory, etc. They are characterized by a structural core formed by a phenethyl alcohol, usually tyrosol or hydroxytyrosol, attached to beta-D-glucopyranose via a glycosidic bond. This core is usually further decorated by attached phenolic acids or another saccharide. Several studies suggest an important role of the saccharidic fragment in the biological activities of PhGs, provoking demand for new glycovariants of natural PhGs. This study presents the preparation of beta-mannosylated analogs of tyrosol beta-D-glucopyranoside (salidroside) and hydroxytyrosol beta-D-glucopyranoside (hydroxysalidroside). While the chemical synthesis of beta-D-mannopyranosides is rather challenging, they can be prepared by enzymatic catalysis. We found that Novozym 188, an industrial beta-glucosidase, also contains beta-mannosidase and used this enzyme in the preparation of tyrosol beta-D-mannopyranoside and hydroxytyrosol beta-D-mannopyranoside in 12 and 16% chemical yields, respectively, by transglycosylation from beta-D-mannopyranosyl-(1 -> 4)-D-mannose. The mannosylation was chemoselective and occurred exclusively on the primary hydroxyls of tyrosol and hydroxytyrosol, and the glycosylation of phenolic moieties of the aglycons was observed.
C1 [Cernakova, Lucia; Haluz, Peter; Mastihuba, Vladimir; Kostalova, Zuzana; Potocka, Elena Karnisova; Mastihubova, Maria] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Institute of Chemistry, SAS
RP Mastihubová, M (corresponding author), Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
EM lucia.cernakova@savba.sk; peter.haluz@savba.sk;
   vladimir.mastihuba@savba.sk; zuzana.kostalova@savba.sk;
   elena.potocka@savba.sk; maria.mastihubova@savba.sk
RI ; Kostalova, Zuzana/Y-7445-2019; Karnišová Potocká, Elena/AAU-9718-2021;
   Mastihuba, Vladimír/S-7938-2017; Mastihubova, Maria/OZG-0746-2025
OI Haluz, Peter/0009-0009-2220-9546; Kostalova, Zuzana/0000-0003-3941-7148;
   Karnišová Potocká, Elena/0000-0003-1546-4134; Mastihubova,
   Maria/0000-0003-3033-811X
FU Slovak Grant Agency for Science VEGA; Slovak Research and Development
   Agency [APVV-18-0188];  [2/0111/22]
FX This research was funded by the Slovak Grant Agency for Science VEGA
   under grant number 2/0111/22 and by the Slovak Research and Development
   Agency under the contract No. APVV-18-0188.
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NR 52
TC 0
Z9 0
U1 3
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2025
VL 30
IS 2
AR 414
DI 10.3390/molecules30020414
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3U8W
UT WOS:001404308700001
PM 39860283
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Choe, KI
   Kwon, JH
   Park, KH
   Oh, MH
   Kim, MH
   Kim, HH
   Cho, SH
   Chung, EK
   Ha, SY
   Lee, MW
AF Choe, Kang In
   Kwon, Joo Hee
   Park, Kwan Hee
   Oh, Myeong Hwan
   Kim, Manh Heun
   Kim, Han Hyuk
   Cho, Su Hyun
   Chung, Eun Kyung
   Ha, Sung Yi
   Lee, Min Won
TI The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds
   Isolated from the Root of Rhodiola sachalinensis A. BOR
SO MOLECULES
LA English
DT Article
DE Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide;
   HPLC
ID NITRIC-OXIDE SYNTHASE; SALIDROSIDE; EXTRACT; INHIBITION; GLYCOSIDES;
   TYROSOL; ROSEA
AB Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-beta-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
C1 [Choe, Kang In; Kwon, Joo Hee; Park, Kwan Hee; Oh, Myeong Hwan; Kim, Manh Heun; Kim, Han Hyuk; Cho, Su Hyun; Chung, Eun Kyung; Ha, Sung Yi; Lee, Min Won] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea.
C3 Chung Ang University
RP Lee, MW (corresponding author), Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea.
EM mwlee@cau.ac.kr
RI Lee, Min/ABG-7067-2020
FU Korea Healthcare Technology R&D Project, Ministry for Health, Welfare
   and Family Affairs, Republic of Korea [A091121]
FX This study was supported by a grant of the Korea Healthcare Technology
   R&D Project, Ministry for Health, Welfare and Family Affairs, Republic
   of Korea (A091121).
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NR 24
TC 73
Z9 97
U1 1
U2 68
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2012
VL 17
IS 10
BP 11484
EP 11494
DI 10.3390/molecules171011484
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 029OO
UT WOS:000310505400014
PM 23018923
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fan, WZ
   Tezuka, Y
   Ni, KM
   Kadota, S
AF Fan, WZ
   Tezuka, Y
   Ni, KM
   Kadota, S
TI Prolyl endopeptidase inhibitors from the underground part of Rhodiola
   sachalinensis
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Rhodiola sachalinensis; Crassulaceae; monoterpenoids; prolyl
   endopeptidase (PEP) inhibitor; Rhodiola Radix
ID GLYCOSIDES; CONSTITUENTS; CRENULATA; ACID
AB The methanolic extract of the underground part of Rhodiola sachalinensis was found to show inhibitory activity on prolyl endopeptidase (PEP, EC. 3.4.21.26), an enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory From the MeOH extract, five new monoterpenoids named sachalinols A (24), B (25) and C (26) and sachalinosides A (23) and B (27) were isolated, together with twenty-two known compounds, gallic acid (1), trans-p-hydroxycinnamic acid (2), p-tyrosol (3), salidroside (4), 6"-O-galloylsalidroside (5), benzyl beta -D-glutopyranoside (6), 2-phenylethyl beta -D-glucopyranoside (7), trails-cinnamyl beta -D-glucopyranoside (8), rosarin (9), rhodiocyanoside A (10), lotaustralin (II), octyl beta -D-glucopyranoside (12), 1,2,3,6-tetra-O-galloyl-beta -D-glucose (13), 1,2;3,4,6-penta-O-galloyl-beta -D-glucose (14), kaempferol (15), kaempferol 3-O-beta -D-xylofuranosyl(1 -->2)-beta -D-glucopyranoside (16), kaempferol 3-O-beta -D-glucopyranosyl(1 -->2)-beta -D-glucopyranoside (17), rhodionin (18), rhodiosin (19), (-)-epigallocatechin (20), 3-O-galloylepigallocatechin-(4 -->8)-epigallocatechin 3-O-gallate (21) and rosiridin (22). Among these, nineteen compounds other than 3, 4 and 9 have been isolated for the first time from R. sachalinensis, and six (6, 8, 13, 16, 17, 20) are isolated from Rhodiola plants for the first time. Among them, six compounds (13, 14, 18, 19, 21, 22) showed noncompetitive inhibition against Flavobacterium PEP, with an IC50 of 0.025, 0.17, 22, 41, 0.44 and 83 muM, respectively.
C1 Toyama Med & Pharmaceut Univ, Inst Nat Med, Sugitani, Toyama 9300194, Japan.
C3 University of Toyama
RP Kadota, S (corresponding author), Toyama Med & Pharmaceut Univ, Inst Nat Med, 2630 Sugitani, Sugitani, Toyama 9300194, Japan.
EM kadota@ms.toyama-mpu.ac.jp
RI /AAD-9606-2019
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NR 38
TC 67
Z9 82
U1 2
U2 35
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD APR
PY 2001
VL 49
IS 4
BP 396
EP 401
DI 10.1248/cpb.49.396
PG 6
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 417CP
UT WOS:000167818100009
PM 11310664
OA Bronze
DA 2026-05-27
ER

PT J
AU Di Stasi, M
   Dolci, D
   Peruzzi, L
   Braca, A
   De Leo, M
AF Di Stasi, Mauro
   Dolci, David
   Peruzzi, Lorenzo
   Braca, Alessandra
   De Leo, Marinella
TI Phytochemical study of Stachys sylvatica (Lamiaceae) aerial parts
SO PLANT BIOSYSTEMS
LA English
DT Article
DE Stachys sylvatica; Lamiaceae; NMR; MS; chemosystematic; isolation;
   UHPLC-ESI-HR-Orbitrap
ID ACYLATED FLAVONE GLYCOSIDES; RADICAL SCAVENGING ACTIVITY; ESSENTIAL OIL
   COMPOSITION; SIBILLINI NATIONAL-PARK; PHENOLIC-COMPOUNDS; MOUNTAIN TEA;
   ANTIOXIDANT ACTIVITY; SIDERITIS-SCARDICA; BIOLOGICAL-ACTIVITY; ENDEMIC
   PLANT
AB In this article, the first complete phytochemical study of Stachys sylvatica (Lamiaceae) aerial parts, collected in Tuscan-Emilian Apennine, is reported. Twenty-three known compounds were isolated from the chloroform, chloroform-methanol 9:1 and methanol extracts; they were subsequently characterized by means of one- and two-dimensional nuclear magnetic resonance spectroscopy (1D- and 2D-NMR) and mass spectrometry as six simple phenolic derivatives (chlorogenic acid (1), caffeic acid (2), p-coumaric acid methyl ester (3), niduloic acid (4), hydroxytyrosol (5), tyrosol (6)), one glycosylated aliphatic alcohol (ebracteatoside B (7)), six glycosylated phenylpropanoids (decaffeoyl verbascoside (8), lavandulifolioside (9), betanyoside F (10), verbascoside (11), isoacteoside (12), cystanoside D (13)), four flavonoids (stachyspinoside (14), chrysoeriol 7-O-beta-D-glucopyranoside (15), naringenin 7-O-(6''-E + Z-p-coumaroyl)-beta-D-glucopyranoside (16), apigenin 7-O-(6''-E + Z-p-coumaroyl)-beta-D-glucopyranoside (17)), three lignans (syringaresinol 4'-O-beta-D-glucopyranoside (18), pinoresinol 4-O-beta-D-glucopyranoside (19), 2-episesaminol 2-O-beta-D-glucopyranoside (20)) and three ionones (loliolide (21), vomifoliol (22), (3S,5R,6R,7E,9R)-3,5,6,9-tetrahydroxy-7-megastigmene (23)). In addition, a further phenolic derivative (ethyl caffeate (b)) and four carboxylic acids (azelaic acid (a), trihydroxyoctadecadienoic acid (c), trihydroxyoctadecenoic acid (d) and dihydroxydodecadienoic acid (e)) have been tentatively identified by ultra-high performance liquid chromatography coupled to an electrospray ionization source high-resolution Orbitrap mass spectrometer (UHPLC-ESI-HR-Orbitrap/MS). Chemosystematic relationships between S. sylvatica and other related species were highlighted.
C1 [Di Stasi, Mauro; Braca, Alessandra; De Leo, Marinella] Univ Pisa, Dipartimento Farm, Pisa, Italy.
   [Dolci, David; Peruzzi, Lorenzo] Univ Pisa, Dipartimento Biol, Pisa, Italy.
   [Peruzzi, Lorenzo; Braca, Alessandra; De Leo, Marinella] CISUP Ctr Instrument Sharing Univ Pisa, Pisa, Italy.
C3 University of Pisa; University of Pisa
RP Braca, A (corresponding author), Univ Pisa, Dipartimento Farm, Pisa, Italy.
EM alessandra.braca@unipi.it
RI ; Peruzzi, Lorenzo/A-4127-2012
OI Di Stasi, Mauro/0000-0002-6526-6585; BRACA,
   ALESSANDRA/0000-0002-9838-0448; Dolci, David/0000-0002-3043-9757
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NR 160
TC 5
Z9 5
U1 3
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1126-3504
EI 1724-5575
J9 PLANT BIOSYST
JI Plant Biosyst.
PD MAY 4
PY 2023
VL 157
IS 3
BP 569
EP 583
DI 10.1080/11263504.2023.2165572
EA JAN 2023
PG 15
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA G3LB0
UT WOS:000921459600001
DA 2026-05-27
ER

PT J
AU Sahakitpichan, P
   Chimnoi, N
   Wongbundit, S
   Vorasingha, A
   Ruchirawat, S
   Kanchanapoom, T
AF Sahakitpichan, Poolsak
   Chimnoi, Nitirat
   Wongbundit, Siriporn
   Vorasingha, Anusorn
   Ruchirawat, Somsak
   Kanchanapoom, Tripetch
TI Phenylethanoid glycosides from the leaves of Magnolia hodgsonii
SO PHYTOCHEMISTRY LETTERS
LA English
DT Article
DE Magnolia hodgsonii; Magnoliaceae; Phenylethanoid glycoside;
   Hodgsoniallosides A-C
ID PHENYLPROPANOID GLYCOSIDE; CONSTITUENTS; OBOVATA; LIGNANS
AB Three new phenylethanoid glycosides, 2-(3-hydroxy-4-methoxyphenyl) ethyl 1-O-beta-D-allopyranoside (hodgsonialloside A, 1), 2-(3-hydroxy-4-methoxyphenyl) ethyl 1-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-allopyranoside (hodgsonialloside B, 2) and 2-(3-methoxy-4-hydroxyphenyl) ethyl 1-O-beta-D-allopyranoside (hodgsonialloside C, 3) were isolated from the leaves of Magnolia hodgsonii in addition to six known compounds, tyrosol 4-O-beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranoside (4), kaempferol 3-O-neohesperidoside (5), kaempferol 3-O-rutinoside (6), kaempferol 3-O-a-L-rhamnopyranosyl-(1 -> 2)-[beta-L-rhamnopyranosyl-(1 -> 6)]-beta-D-glucopyranoside (7), (+)-syringaresinol O-beta-D-glucopyranoside (8), and oblongionoside C (9). The structure elucidation of these compounds was based on analyses of physical and spectroscopic data including 1D and 2D NMR experiments.
C1 [Sahakitpichan, Poolsak; Chimnoi, Nitirat; Wongbundit, Siriporn; Ruchirawat, Somsak; Kanchanapoom, Tripetch] Chulabhorn Res Inst, Kamphaeng Phet 6, Bangkok 10210, Thailand.
   [Vorasingha, Anusorn] Naresuan Univ, Fac Sci, Phitsanulok 65000, Thailand.
   [Kanchanapoom, Tripetch] Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen 40002, Thailand.
C3 Chulabhorn Research Institute; Naresuan University; Khon Kaen University
RP Kanchanapoom, T (corresponding author), Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen 40002, Thailand.
EM trikan@kku.ac.th
OI Ruchirawat, Somsak/0000-0001-5842-4330
FU Chulabhorn Research Institute, Khon Kaen University; Mahidol University
FX This research work was supported by the grant from Chulabhorn Research
   Institute, Khon Kaen University and Mahidol University. The authors also
   thank Mr. Thinakorn Komkris for providing the plant materials from his
   garden, Khao Kho, Phetchabun Province, Thailand.
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NR 19
TC 12
Z9 12
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3900
EI 1876-7486
J9 PHYTOCHEM LETT
JI Phytochem. Lett.
PD SEP
PY 2017
VL 21
BP 269
EP 272
DI 10.1016/j.phytol.2017.07.014
PG 4
WC Plant Sciences; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy
GA FL4VJ
UT WOS:000414229300053
DA 2026-05-27
ER

PT J
AU Ma, DD
   Wang, LJ
   Jin, YB
   Gu, LF
   Yu, XA
   Xie, XQ
   Yin, G
   Wang, J
   Bi, KS
   Lu, Y
   Wang, TJ
AF Ma, Didi
   Wang, Lijun
   Jin, Yibao
   Gu, Lifei
   Yu, Xiean
   Xie, Xueqing
   Yin, Guo
   Wang, Jue
   Bi, Kaishun
   Lu, Yi
   Wang, Tiejie
TI Application of UHPLC Fingerprints Combined with Chemical Pattern
   Recognition Analysis in the Differentiation of Six Rhodiola
   Species
SO MOLECULES
LA English
DT Article
DE Rhodiola; UHPLC fingerprint; chemical pattern recognition; quality
   evaluation
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; QUALITY EVALUATION; CLASSIFICATION;
   AUTHENTICATION; IDENTIFICATION; SALIDROSIDE; EFFICACY; TYROSOL; TEA
AB Rhodiola, especially Rhodiola crenulate and Rhodiola rosea, is an increasingly widely used traditional medicine or dietary supplement in Asian and western countries. Because of the phytochemical diversity and difference of therapeutic efficacy among Rhodiola species, it is crucial to accurately identify them. In this study, a simple and efficient method of the classification of Rhodiola crenulate, Rhodiola rosea, and their confusable species (Rhodiola serrata, Rhodiola yunnanensis, Rhodiola kirilowii and Rhodiola fastigiate) was established by UHPLC fingerprints combined with chemical pattern recognition analysis. The results showed that similarity analysis and principal component analysis (PCA) could not achieve accurate classification among the six Rhodiola species. Linear discriminant analysis (LDA) combined with stepwise feature selection exhibited effective discrimination. Seven characteristic peaks that are responsible for accurate classification were selected, and their distinguishing ability was successfully verified by partial least-squares discriminant analysis (PLS-DA) and orthogonal partial least-squares discriminant analysis (OPLS-DA), respectively. Finally, the components of these seven characteristic peaks were identified as 1-(2-Hydroxy-2-methylbutanoate) beta-D-glucopyranose, 4-O-glucosyl-p-coumaric acid, salidroside, epigallocatechin, 1,2,3,4,6-pentagalloyglucose, epigallocatechin gallate, and (+)-isolarisiresinol-4 & PRIME;-O-beta-D-glucopyranoside or (+)-isolarisiresinol-4-O-beta-D-glucopyranoside, respectively. The results obtained in our study provided useful information for authenticity identification and classification of Rhodiola species.
C1 [Ma, Didi; Xie, Xueqing; Bi, Kaishun; Wang, Tiejie] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China.
   [Ma, Didi; Wang, Lijun; Jin, Yibao; Gu, Lifei; Yu, Xiean; Xie, Xueqing; Yin, Guo; Wang, Jue; Lu, Yi; Wang, Tiejie] Shenzhen Inst Drug Control, Shenzhen 518057, Guangdong, Peoples R China.
   [Ma, Didi; Wang, Lijun; Jin, Yibao; Gu, Lifei; Yu, Xiean; Xie, Xueqing; Yin, Guo; Wang, Jue; Lu, Yi; Wang, Tiejie] Shenzhen Inst Drug Control, NMPA Key Lab Qual Res & Evaluat Tradit Chinese Me, Shenzhen 518057, Guangdong, Peoples R China.
   [Ma, Didi; Wang, Lijun; Jin, Yibao; Gu, Lifei; Yu, Xiean; Xie, Xueqing; Yin, Guo; Wang, Jue; Lu, Yi; Wang, Tiejie] Shenzhen Inst Drug Control, Shenzhen Key Lab Drug Qual Stand Res, Shenzhen 518057, Guangdong, Peoples R China.
C3 Shenyang Pharmaceutical University
RP Wang, TJ (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China.; Lu, Y; Wang, TJ (corresponding author), Shenzhen Inst Drug Control, Shenzhen 518057, Guangdong, Peoples R China.; Lu, Y; Wang, TJ (corresponding author), Shenzhen Inst Drug Control, NMPA Key Lab Qual Res & Evaluat Tradit Chinese Me, Shenzhen 518057, Guangdong, Peoples R China.; Lu, Y; Wang, TJ (corresponding author), Shenzhen Inst Drug Control, Shenzhen Key Lab Drug Qual Stand Res, Shenzhen 518057, Guangdong, Peoples R China.
OI Yu, Xie-an/0000-0003-2918-7369
FU Special Project of Science and Technology for Sustainable Development,
   Shenzhen Municipal Science and Technology Innovation Committee
   [KCXFZ20201221173005015]
FX FundingThis research was funded by the Special Project of Science and
   Technology for Sustainable Development, Shenzhen Municipal Science and
   Technology Innovation Committee (KCXFZ20201221173005015).
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NR 29
TC 11
Z9 14
U1 5
U2 66
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2021
VL 26
IS 22
AR 6855
DI 10.3390/molecules26226855
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XF3WG
UT WOS:000724003900001
PM 34833946
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Horvathova, E
   Mastihubova, M
   Potocka, EK
   Kis, P
   Galova, E
   Sevcovicova, A
   Klapakova, M
   Hunakova, L
   Mastihuba, V
AF Horvathova, Eva
   Mastihubova, Maria
   Potocka, Elena Karnisova
   Kis, Peter
   Galova, Eliska
   Sevcovicova, Andrea
   Klapakova, Martina
   Hunakova, Luba
   Mastihuba, Vladimir
TI Comparative study of relationship between structure of phenylethanoid
   glycopyranosides and their activities using cell-free assays and human
   cells cultured in vitro
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Phenylethanoid glycopyranosides; Antioxidant effects; Cytotoxicity;
   Chemoprotective potential; DNA protectivity; Glutathione
ID HEPG2 CELLS; OLIVE OIL; SALIDROSIDE ANALOGS; ENZYMATIC-SYNTHESIS;
   BETA-GLUCOSIDASE; DNA-DAMAGE; APPLE SEED; ANTIOXIDANT; HYDROXYTYROSOL;
   TYROSOL
AB The study focused on protective potential of phytochemicals applicable in prevention and health protection is of great importance. Various structures of these compounds and a wide range of their biological activities have inspired organic chemists to sythesize their effective analogues in order to further increase their efficacy.
   The aims of our study were (i) to synthesize phenylethanoid glycopyranosides: salidroside (SALI - tyrosol beta-Dglucopyranoside), tyrosol beta-D-galactopyranoside (TYBGAL), tyrosol alpha-D-galactopyranoside (TYAGAL), tyrosol alpha-D-mannopyranoside (TYAMAN), hydroxytyrosol alpha-D-mannopyranoside (HOTAMA), homosyringyl beta-D-glucopyranoside (HSYGLU), hydroxytyrosol beta-D-xylopyranoside (HOTXYL) and hydroxysalidroside (HOSALI); (ii) to determine their antioxidant capacities (cell-free approaches); (iii) to evaluate their cytotoxicity (MTT test), protectivity against hydrogen peroxide (H2O2; comet assay) and effect on the intracellular glutathione level (iGSH; flow cytometry) in experimental system utilizing human hepatoma HepG2 cells.
   HOSALI, HOTAMA, HOTXYL and HSYGLU manifested the highest antioxidant capacity in cell-free assays and they were most active in protection of HepG2 cells against H2O2. On the other hand, pre-treatment of HepG2 cells with SALI had protective effects even though SALT displayed almost no activity in cell-free assays.
   Differences in the efficacy of the analogues revealed that structures of their molecules in terms of aglycone combined with sugar moiety affect their activities.
C1 [Horvathova, Eva; Hunakova, Luba] Univ Sci Pk Biomed, Slovak Acad Sci, Canc Res Inst, Biomed Res Ctr, Dubravska Cesta 9, Bratislava 84505, Slovakia.
   [Mastihubova, Maria; Potocka, Elena Karnisova; Kis, Peter; Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, Bratislava 84538, Slovakia.
   [Galova, Eliska; Sevcovicova, Andrea; Klapakova, Martina] Comenius Univ, Dept Genet, Fac Nat Sci, Bratislava 84215, Slovakia.
C3 Slovak Academy of Sciences; Cancer Research Institute, SAS; Biomedical
   Research Center, SAS; Slovak Academy of Sciences; Institute of
   Chemistry, SAS; Comenius University Bratislava
RP Horvathova, E (corresponding author), Univ Sci Pk Biomed, Slovak Acad Sci, Canc Res Inst, Biomed Res Ctr, Dubravska Cesta 9, Bratislava 84505, Slovakia.
EM Eva.Horvathova@savba.sk
RI Kis, Peter/AAT-4712-2021; Gálová, Eliška/AAE-7043-2021; Mastihuba,
   Vladimír/S-7938-2017; Hunakova, Luba/E-4523-2015; Sevcovicova,
   Andrea/N-9253-2018; Karnišová Potocká, Elena/AAU-9718-2021; Mastihubova,
   Maria/OZG-0746-2025; Horvathova, Eva/B-8638-2019
OI Kis, Peter/0000-0001-8827-0635; Gálová, Eliška/0000-0003-3494-4432;
   Mastihuba, Vladimír/0000-0003-2587-2553; Hunakova,
   Luba/0000-0003-2159-0807; Sevcovicova, Andrea/0000-0003-2912-5184;
   Karnišová Potocká, Elena/0000-0003-1546-4134; Mastihubova,
   Maria/0000-0003-3033-811X; Horvathova, Eva/0000-0003-1496-5922
FU Scientific Grant Agency of the Ministry of Education of Slovak Republic;
   Slovak Academy of Sciences [VEGA 2/0084/16, 2/0126/19]; Research AMP;
   Development Operational Programme - ERDF [ITMS: 26240120008, ITMS:
   26240220071]
FX This study was supported by the Scientific Grant Agency of the Ministry
   of Education of Slovak Republic and the Slovak Academy of Sciences
   (grants VEGA 2/0084/16 and 2/0126/19) and the project implementations:
   TRANSMED, ITMS: 26240120008 and ITMS: 26240220071 supported by the
   Research & Development Operational Programme funded by the ERDF.
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NR 76
TC 9
Z9 11
U1 1
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD DEC
PY 2019
VL 61
AR 104646
DI 10.1016/j.tiv.2019.104646
PG 11
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA JO0BD
UT WOS:000497251800038
PM 31518671
DA 2026-05-27
ER

PT J
AU Langeder, J
   Grienke, U
   Döring, K
   Jafari, M
   Ehrhardt, C
   Schmidtke, M
   Rollinger, JM
AF Langeder, Julia
   Grienke, Ulrike
   Doering, Kristin
   Jafari, Mahtab
   Ehrhardt, Christina
   Schmidtke, Michaela
   Rollinger, Judith M.
TI High-performance Countercurrent Chromatography to Access Rhodiola
   rosea Influenza Virus Inhibiting Constituents
SO PLANTA MEDICA
LA English
DT Article
DE high-performance countercurrent chromatography; Rhodiola rosea;
   Crassulaceae; influenza virus; human rhinovirus; antiviral
ID PHENYLPROPANOID GLYCOSIDES; MONOTERPENE GLYCOSIDES; ACID-DERIVATIVES;
   L.; SALIDROSIDE; SEPARATION; PURIFICATION; FATIGUE; TRICIN; PLANTS
AB In a cytopathic effect inhibition assay, a standardized Rhodiola rosea root and rhizome extract, also known as roseroot extract (SHR-5), exerted distinct anti-influenza A virus activity against HK/68 (H3N2) (IC (50) of 2.8 mu g/mL) without being cytotoxic. For fast and efficient isolation and identification of the extracts bioactive constituents, a high-performance countercurrent chromatographic separation method was developed. It resulted in a three-stage gradient elution program using a mobile phase solvent system composed of ethyl acetate/ n -butanol/water (1:4:5 -> 2:3:5 -> 3:2:5) in the reversed-phase mode. The elaborated high-performance countercurrent chromatographic method allowed for fractionation of the complex roseroot extract in a single chromatographic step in a way that only one additional orthogonal isolation/purification step per fraction yielded 12 isolated constituents. They cover a broad polarity range and belong to different structural classes, namely, the phenylethanoid tyrosol and its glucoside salidroside, the cinnamyl alcohol glycosides rosavin, rosarin, and rosin as well as gallic acid, the cyanogenic glucoside lotaustralin, the monoterpene glucosides rosiridin and kenposide A, and the flavonoids tricin, tricin-5- O - beta -D-glucopyranoside, and rhodiosin. The most promising anti-influenza activities were determined for rhodiosin, tricin, and tricin-5- O - beta -D-glucopyranoside with IC (50) values of 7.9, 13, and 15 mu M, respectively. The herein established high-performance countercurrent chromatographic protocol enables fast and scalable access to major as well as minor roseroot constituents. This is of particular relevance for extract standardization, quality control, and further in-depth pharmacological investigations of the metabolites of this popular traditional herbal remedy.
C1 [Langeder, Julia; Grienke, Ulrike; Rollinger, Judith M.] Univ Vienna, Dept Pharmacognosy, Vienna, Austria.
   [Doering, Kristin; Ehrhardt, Christina; Schmidtke, Michaela] Jena Univ, Sect Expt Virol, Dept Med Microbiol, Jena, Germany.
   [Jafari, Mahtab] Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA USA.
C3 University of Vienna; University of California System; University of
   California Irvine
RP Grienke, U (corresponding author), Univ Vienna, Dept Pharmacognosy, Fac Life Sci, Althanstr 14, A-1090 Vienna, Austria.
EM Ulrike.Grienke@univie.ac.at
RI ; Grienke, Ulrike/H-2585-2017; Rollinger, Judith/Q-5996-2019; Schmidtke,
   Michaela/PFZ-8576-2026
OI Langeder, Julia/0000-0002-1991-9274; Grienke,
   Ulrike/0000-0003-0305-9270; Rollinger, Judith/0000-0001-6581-0774; 
FU Natvantage grant (2018) [Wilhelm Doerenkamp-Foundation, Chur,
   Switzerland] Funding Source: Medline
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NR 47
TC 9
Z9 10
U1 1
U2 30
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD AUG
PY 2021
VL 87
IS 10/11
BP 818
EP 826
DI 10.1055/a-1228-8473
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA UE9NO
UT WOS:000688209500007
PM 32781473
OA gold
DA 2026-05-27
ER

PT J
AU Qian, EW
   Ge, DT
   Kong, SK
AF Qian, Erin Wei
   Ge, Daniel Tianfang
   Kong, Siu-Kai
TI Salidroside Protects Human Erythrocytes against Hydrogen
   Peroxide-Induced Apoptosis
SO JOURNAL OF NATURAL PRODUCTS
LA English
DT Article
ID PROGRAMMED CELL-DEATH; RHODIOLA-ROSEA; SIGNAL-TRANSDUCTION; DEPENDENT
   PATHWAY; EXTRACT; MITOCHONDRIA; ACTIVATION; SENESCENCE; ERYPTOSIS;
   PLACEBO
AB Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study therefore has investigated the effects of 1 on oxidative stress-induced apoptosis in human erythrocytes (also known as eryptosis or erythroptosis). Compound 1 increased cell survival significantly and prevented human erythrocytes from undergoing eryptosis/erythroptosis mediated by H2O2, as confirmed by the decreased expression of phosphatidylserine On the cell surface and reduced leakage of calcein through the damaged membrane. Mechanistically, 1 was found to exert its protective effects through its antioxidative activity and the inhibition of caspase-3 activation and stress-induced intracellular Ca2+ rise in a dose-dependent manner. Compound 1 is a protective agent in human erythrocytes against oxidative stress and may be a good adaptogen to enhance the body's resistance to stress and fatigue.
C1 [Qian, Erin Wei; Ge, Daniel Tianfang; Kong, Siu-Kai] Chinese Univ Hong Kong, Sch Life Sci, Programme Biochem, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Kong, SK (corresponding author), Chinese Univ Hong Kong, Sch Life Sci, Programme Biochem, Shatin, Hong Kong, Peoples R China.
EM skkong@cuhk.edu.hk
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NR 39
TC 119
Z9 124
U1 1
U2 46
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0163-3864
EI 1520-6025
J9 J NAT PROD
JI J. Nat. Prod.
PD APR
PY 2012
VL 75
IS 4
BP 531
EP 537
DI 10.1021/np200555s
PG 7
WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy
GA 931LD
UT WOS:000303220500002
PM 22483064
DA 2026-05-27
ER

PT J
AU Choi, SY
   Kim, MJ
   Kim, SH
   Chun, W
   Oh, K
   Kwon, Y
AF Choi, Seong Yeon
   Kim, Myong Jo
   Kim, Seok Ho
   Chun, Wanjoo
   Oh, Kyungsoo
   Kwon, Yongsoo
TI A New Carotane Sesquiterpene Glycoside from the Leaves of Angelica
   polymorpha
SO CHEMISTRY OF NATURAL COMPOUNDS
LA English
DT Article
DE <italic>Angelica polymorpha</italic>; leaves; carotane sesquiterpenoid
ID CONSTITUENTS
AB A new carotane sesquiterpene glycoside, 3 beta-(2-hydroxypropan-2-yl)-6,8a beta-dimethyl-1 beta,2,3 alpha,3a alpha,4,8a-hexahydroazulene-1 alpha-O-beta-D-glucopyranoside (polymorpholide-1-O-glucocside, 7), along with known compounds 2-[4 '-phenyl]-2-hydroxy-ethanol (1), tyrosol (2), protocatechuic acid (3), vanilic acid (4), cimifugin (5), uracil (6), and 5,7-dihydroxychromone-2-carboxylic acid (8) were isolated from the leaves of Angelica polymorpha. Their structures were elucidated using spectroscopic method, including extensive 2D NMR techniques.
C1 [Choi, Seong Yeon; Kim, Seok Ho; Kwon, Yongsoo] Kangwon Natl Univ, Coll Pharm, Chunchon 24341, South Korea.
   [Kim, Myong Jo] Kangwon Natl Univ, Coll Agr & Life Sci, Chunchon 24341, South Korea.
   [Chun, Wanjoo] Kangwon Natl Univ, Coll Med, Chunchon 24341, South Korea.
   [Oh, Kyungsoo] Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea.
C3 Kangwon National University; Kangwon National University; Kangwon
   National University; Chung Ang University
RP Kwon, Y (corresponding author), Kangwon Natl Univ, Coll Pharm, Chunchon 24341, South Korea.
EM yskwon@kangwon.ac.kr
RI KIM, SEOK-HO/LMN-7906-2024
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NR 14
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0009-3130
EI 1573-8388
J9 CHEM NAT COMPD+
JI Chem. Nat. Compd.
PD MAY
PY 2025
VL 61
IS 3
BP 483
EP 486
DI 10.1007/s10600-025-04683-6
EA MAY 2025
PG 4
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 3FR3T
UT WOS:001489527800001
DA 2026-05-27
ER

PT J
AU Li, ST
   Ji, Y
   Zhu, SL
   Liu, M
   Luo, D
   Luo, QM
   Mo, M
   Long, HB
   Peng, FF
   Jia, ZJ
   Dou, XR
AF Li, Shuting
   Ji, Yue
   Zhu, Silin
   Liu, Mi
   Luo, Dan
   Luo, Qimei
   Mo, Min
   Long, Haibo
   Peng, Fenfen
   Jia, Zhanjun
   Dou, Xianrui
TI Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology
   reveals protective effect of salidroside in peritoneal
   dialysis-associated peritoneal fibrosis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; peritoneal dialysis; peritoneal fibrosis; single-cell RNA;
   network pharmacology
ID MESENCHYMAL TRANSITION; MACROPHAGES; ACTIVATION; MEMBRANE
AB Salidroside (2- (4-Hydroxyphenyl) ethyl beta-D-glucopyranoside, SAL) is a bioactive compound present in Rhodiola rosea L., exhibiting diverse pharmacological properties such as anti-inflammatory and anti-fibrotic effects. Despite its known benefits, the therapeutic potential of SAL in peritoneal dialysis (PD) -induced peritoneal fibrosis remains unexplored. This study aims to investigate the protective effects of SAL in PD-related peritoneal fibrosis and its underlying mechanisms through the integration of single-cell RNA-seq, bulk RNA-seq, and network pharmacology analyses. A total of 249 disease targets were identified through single-cell RNA-seq and bulk RNA-seq analyses. Functional enrichment analysis highlighted the involvement of extracellular matrix organization, neutrophil degranulation, and the vitamin D receptor (VDR) pathway in peritoneal fibrosis. By intersecting 148 drug targets with the 249 disease targets, four therapeutic targets for SAL treatment against peritoneal fibrosis were pinpointed: cathepsin S, VDR, plasminogen activator urokinase, and galectin 3. In a murine model of peritoneal fibrosis induced by intraperitoneal injection of 4.25% PD fluid, SAL treatment significantly mitigated peritoneal fibrosis, as evidenced by reduced collagen deposition, decreased protein expression of alpha-smooth muscle actin and Collagen I, and a thinner peritoneum. In vitro experiments demonstrated that SAL treatment inhibited extracellular matrix deposition, potentially through upregulation of VDR expression. In conclusion, SAL may target VDR domains as a therapeutic agent for PD-related peritoneal fibrosis. These findings comprehensively identify potential therapeutic targets for SAL in combating peritoneal fibrosis, providing a theoretical basis for the clinical application of SAL in the treatment of peritoneal fibrosis.
C1 [Li, Shuting; Ji, Yue; Zhu, Silin; Liu, Mi; Luo, Dan; Luo, Qimei; Mo, Min; Dou, Xianrui] Southern Med Univ, Peoples Hosp Shunde Foshan 1, Affiliated Hosp 8, Dept Nephrol, Foshan, Peoples R China.
   [Long, Haibo; Peng, Fenfen] Southern Med Univ, Zhujiang Hosp, Dept Nephrol, Guangzhou, Peoples R China.
   [Jia, Zhanjun] Nanjing Med Univ, Childrens Hosp, Nanjing Key Lab Pediat, Nanjing, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Nanjing Medical University
RP Dou, XR (corresponding author), Southern Med Univ, Peoples Hosp Shunde Foshan 1, Affiliated Hosp 8, Dept Nephrol, Foshan, Peoples R China.; Peng, FF (corresponding author), Southern Med Univ, Zhujiang Hosp, Dept Nephrol, Guangzhou, Peoples R China.; Jia, ZJ (corresponding author), Nanjing Med Univ, Childrens Hosp, Nanjing Key Lab Pediat, Nanjing, Peoples R China.
EM betty9911@163.com; jiazj72@hotmail.com; doctorpff@163.com
RI ; Peng, Fenfen/ISA-9238-2023; Liu, Mi/KVA-8310-2024
OI dou, xianrui/0000-0003-4188-6015; Jia, Zhanjun/0000-0002-3107-0429; 
FU Guangdong Basic and Applied Basic Research Foundation, China
   [2023A1515110985]; Natural Science Foundation of Guangdong Province,
   China [2024A1515013228]; Scientific Research Start Plan of Shunde
   Hospital, Southern Medical University [SRSP2023012, SRSP2024006,
   SRSP2023028]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   the Guangdong Basic and Applied Basic Research Foundation, China (no.
   2023A1515110985), the Natural Science Foundation of Guangdong Province,
   China (no. 2024A1515013228), the Scientific Research Start Plan of
   Shunde Hospital, Southern Medical University (nos SRSP2023012,
   SRSP2024006, and SRSP2023028).
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NR 46
TC 1
Z9 1
U1 2
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 20
PY 2025
VL 16
AR 1558366
DI 10.3389/fphar.2025.1558366
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4NO5C
UT WOS:001522267500001
PM 40620673
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yang, DW
   Kang, OH
   Lee, YS
   Han, SH
   Lee, SW
   Cha, SW
   Seo, YS
   Mun, SH
   Gong, R
   Shin, DW
   Kwon, DY
AF Yang, Da-Wun
   Kang, Ok-Hwa
   Lee, Young-Seob
   Han, Sin-Hee
   Lee, Sang-Won
   Cha, Seon-Woo
   Seo, Yun-Soo
   Mun, Su-Hyun
   Gong, Ryong
   Shin, Dong-Won
   Kwon, Dong-Yeul
TI Anti-inflammatory effect of salidroside on
   phorbol-12-myristate-13-acetate plus A23187-mediated inflammation in
   HMC-1 cells
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE salidroside; mast cells; pro-inflammatory cytokines; nuclear
   factor-kappa B
ID ACTIVATED PROTEIN-KINASES; HUMAN MAST-CELLS; RHODIOLA-ROSEA L.;
   EPSILON-RI-ALPHA; NF-KAPPA-B; IMMUNE-RESPONSES; LINE; TNF;
   INTERLEUKIN-8; TRANSCRIPTION
AB Salidroside [2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside (SAS)] has been identified as the most potent ingredient of the plant Rhodiola rosea L. Previous studies have demonstrated that it possesses a number of pharmacological properties, including anti-aging, anti-fatigue, antioxidant, anticancer and anti-inflammatory properties. In this study, to ascertain the molecular mechanisms responsible for the anti-inflammatory activity of SAS, we used phorbol-12-myristate-13-acetate (PMA) plus A23187 to induce inflammation in human mast cell line-1 (HMC-1). The HMC-1 cells were treated with SAS prior to being stimulated with PMA plus A23187. Pro-inflammatory cytokine production was measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR). Western blot analysis was used to examine the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). SAS inhibited the mRNA expression and production of interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF). In cells stimulated with PMA plus A23187, SAS suppressed the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and c-jun N-terminal kinase 1/2 (JNK1/2), but not that of p38 MAPK. SAS suppressed the expression of NF-kappa B in the nucleus. On the whole, our results suggest that SAS exerts an anti-inflammatory effect by inhibiting the production of pro-inflammatory cytokines through the blocking of the NF-kappa B and MAPK signaling pathways.
C1 [Yang, Da-Wun; Mun, Su-Hyun; Gong, Ryong] Wonkwang Univ, Profess Grad Sch Oriental Med, Plus Team BK21, Iksan 570749, Jeonbuk, South Korea.
   [Kang, Ok-Hwa; Seo, Yun-Soo; Kwon, Dong-Yeul] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Jeonbuk, South Korea.
   [Kang, Ok-Hwa; Seo, Yun-Soo; Kwon, Dong-Yeul] Wonkwang Univ, Inst Biotechnol, Wonkwang Oriental Med Res Inst, Iksan 570749, Jeonbuk, South Korea.
   [Lee, Young-Seob; Han, Sin-Hee; Lee, Sang-Won; Cha, Seon-Woo] RDA, Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, Eumseong 369873, Chungbuk, South Korea.
   [Shin, Dong-Won] Sunchon Natl Univ, Dept Oriental Med Resources, Jeonnam 540742, South Korea.
C3 Wonkwang University; Wonkwang University; Wonkwang University; Rural
   Development Administration (RDA), Republic of Korea; National Institute
   of Horticultural & Herbal Science (NIHHS), Republic of Korea; Sunchon
   National University
RP Kang, OH; Kwon, DY (corresponding author), Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Jeonbuk, South Korea.; Kang, OH; Kwon, DY (corresponding author), Wonkwang Univ, Inst Biotechnol, Wonkwang Oriental Med Res Inst, Iksan 570749, Jeonbuk, South Korea.
EM kangokhwa@hanmail.net; sssimi@wku.ac.kr
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NR 42
TC 19
Z9 23
U1 0
U2 12
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD DEC
PY 2016
VL 38
IS 6
BP 1864
EP 1870
DI 10.3892/ijmm.2016.2781
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EG5IE
UT WOS:000391076700026
PM 27779653
OA Bronze
DA 2026-05-27
ER

PT J
AU Langeder, J
   Grienke, U
AF Langeder, Julia
   Grienke, Ulrike
TI A supercritical fluid workflow for the quality assessment of herbal
   drugs and commercial preparations from Rhodiola rosea
SO PHYTOCHEMICAL ANALYSIS
LA English
DT Article
DE commercial product; herbal drug; quality control; Rhodiola rosea; SFC;
   SFE
AB Introduction Preparations from the Rhodiola rosea are experiencing an increase in popularity: extracts of dried roots and rhizomes are used as adaptogen to treat stress, fatigue, and weakness. To meet high pharmaceutical standards, fast and reliable methods to assess phytochemical variations in respect of quality control are needed.
   Objective The aim of this study was to extract and quantify seven characteristic secondary metabolites of R. rosea, namely p-tyrosol (1), rosin (2), rosiridin (3), salidroside (4), rosarin (5), rosavin (6), and tricin-5-O-beta-d-glucopyranoside (7) in 24 herbal drugs and seven commercial preparations using a newly established supercritical fluid workflow.
   Methods The developed protocol allowed for an exhaustive extraction of compounds 1-7 using 60% carbon dioxide (CO2) and 40% methanol. The constituents were analysed on an ultra-high-performance supercritical fluid chromatography (UHPSFC) instrument using a charged surface hybrid fluoro-phenyl (CSH FP) column (3.0 mm x 100 mm, 1.7 mu m; mobile phase: CO2 and methanol).
   Results The seven compounds were separated in a remarkably short time (< 3.5 minutes). For their quantitation, good results in terms of selectivity, linearity (R-2 >= 0.99), precision (intraday <= 3.03%, interday <= 5.17%) and accuracy (recovery rates 96.6-102.4%) were achieved using selected ion recording on a Quadrupole Dalton (QDa) mass detector.
   Conclusion The quantitative analysis of the investigated herbal drugs showed a highly differing metabolite pattern which was also observed in the investigated commercial products. None of the commercial dietary products met the declared content of rosavins and salidroside. The developed and validated protocol offers a novel and reliable method to assess the quantitative composition of Rhodiola herbal drugs and preparations.
C1 [Langeder, Julia; Grienke, Ulrike] Univ Vienna, Dept Pharmacognosy, Vienna, Austria.
C3 University of Vienna
RP Grienke, U (corresponding author), Univ Vienna, Dept Pharmacognosy, Fac Life Sci, Althanstr 14, A-1090 Vienna, Austria.
EM ulrike.grienke@univie.ac.at
RI ; Grienke, Ulrike/H-2585-2017
OI Langeder, Julia/0000-0002-1991-9274; Grienke, Ulrike/0000-0003-0305-9270
FU Wilhelm Doerenkamp Foundation, Chur, Switzerland [Natvantage Grant 2018]
FX Wilhelm Doerenkamp Foundation, Chur, Switzerland, Grant/Award Number:
   Natvantage Grant 2018
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NR 36
TC 10
Z9 10
U1 2
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0344
EI 1099-1565
J9 PHYTOCHEM ANALYSIS
JI Phytochem. Anal.
PD NOV
PY 2021
VL 32
IS 6
BP 982
EP 991
DI 10.1002/pca.3040
EA FEB 2021
PG 10
WC Biochemical Research Methods; Plant Sciences; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Chemistry
GA WD6LZ
UT WOS:000622180300001
PM 33638206
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wen, SY
   Chen, YY
   Lu, JX
   Liang, QQ
   Shi, H
   Wu, Q
   Yao, ZH
   Zhu, Y
   Jiang, MM
AF Wen, Shi-yuan
   Chen, Yan-yan
   Lu, Jia-xi
   Liang, Qian-qian
   Shi, Hong
   Wu, Qian
   Yao, Zhi-hong
   Zhu, Yan
   Jiang, Miao-miao
TI Modulation of hepatic lipidome by rhodioloside in high-fat diet fed
   apolipoprotein E knockout mice
SO PHYTOMEDICINE
LA English
DT Article
DE Alkenyldiacylglycerol; Alkyldiacylglycerol; Atherosclerosis;
   Phosphatidylcholine; Salidroside
ID CARDIOVASCULAR-DISEASE; ALZHEIMERS-DISEASE; RISK; SALIDROSIDE;
   PLASMALOGENS; SAMPLES; MODEL; ACIDS
AB Background: Rhodioloside is a glucoside of tyrosol isolated from Rhodiola rosea. However, its regulating effect on hepatic dyslipidemia of atherogenic mice has rarely been studied.
   Purpose: The specific aims of current study included to clarify lipidomic perturbation in liver tissues of apolipoprotein E deficient (apoE(-/-)) mice fed with high-fat diet, and to examine the effects of rhodioloside against atherosclerosis and dyslipidemia.
   Study Design: The comparisons of hepatic lipidome were executed between wide type (WT) mice fed with normal diet (NDC) and apoE(-/-) mice fed with high-fat diet (Model), WT mice fed with high-fat diet (HFDC) versus the model mice, as well as the model mice versus rhodioloside-treated atherosclerotic mice.
   Methods: Ultra high performance liquid chromatography coupled with a Q exactive hybrid quadrupole-orbitrap mass spectrometry (UPLC-MS/MS) was employed to provide an unbiased and simultaneous measurement of individual lipid species in liver tissues.
   Results: Multivariate statistical analysis derived from LC-MS spectra revealed that high-fat diet and apoE deficiency caused a series of disturbances on glyerolipid metabolism, glycerophospholipid metabolism and sphingolipid metabolism. Rhodioloside administration showed atheroprotective effects on the apoE(-/-) mice with regulating the levels of 1 phosphatidylcholine, 2 phosphatidylserines, 5 alkyldiacylglycerols and 3 alkenyldiacylglycerols back to normal. In particular, PC (4:0/15:0) was positively associated with high-density lipoprotein cholesterol in blood, both of which could be ameliorated by rhodioloside.
   Conclusion: Our results identified the abnormal hepatic lipids in atherosclerosis progression that could efficiently improved by rhodioloside. These lipids contributed to biological understanding of atherogenic dyslipidemia in liver and could also served as sensitive indicators for drug target screening.
C1 [Wen, Shi-yuan; Chen, Yan-yan; Lu, Jia-xi; Liang, Qian-qian; Shi, Hong; Zhu, Yan; Jiang, Miao-miao] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China.
   [Wu, Qian] Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China.
   [Wen, Shi-yuan; Chen, Yan-yan; Yao, Zhi-hong] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Chinese Academy of
   Sciences; Jinan University
RP Jiang, MM (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China.; Wu, Q (corresponding author), Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China.
EM wuqian@scbit.org; miaomiaojiang@tjutcm.edu.cn
RI Zhu, Yan/A-1548-2017; Wen, Shi-Yuan/PNF-0252-2026
OI Zhu, Yan/0000-0002-3197-7936; 
FU National Natural Science Foundation of China [81573547]; Open Fund of
   Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM
   and New Drugs Research [2016B030301004]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81573547) and the Open Fund of Guangdong Province Key
   Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research
   (No. 2016B030301004).
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NR 30
TC 13
Z9 16
U1 1
U2 33
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR
PY 2020
VL 69
AR 152690
DI 10.1016/j.phymed.2018.09.225
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA LM1WT
UT WOS:000532044500013
PM 30389273
DA 2026-05-27
ER

PT J
AU Zhang, X
   Du, QM
   Liu, C
   Yang, Y
   Wang, JN
   Duan, SQ
   Duan, JG
AF Zhang, Xu
   Du, Qianming
   Liu, Chao
   Yang, Yan
   Wang, Jianing
   Duan, Suqian
   Duan, Junguo
TI Rhodioloside ameliorates depressive behavior via up-regulation of
   monoaminergic system activity and anti-inflammatory effect in olfactory
   bulbectomized rats
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Rhodioloside; Olfactory bulbectomy; Depression; Monoaminergic system;
   Pro-inflammatory cytokine; NF-kappa B
ID MODEL; CYTOKINES; SALIDROSIDE; STRESS
AB Rhodioloside, a major constituent from roots of Rhodiola rosea, has been previously confirmed to alleviate the hyperactivity in olfactory bulbectomized (OBX) rats exposed to the open field and to decrease the immobility time in the forced swimming test (FST) and tail suspension test (TST). However, its antidepressant effects and mechanisms remain unclear. This study aimed to evaluate the antidepressant effect and the potential mechanisms of rhodioloside in OBX rats. ELISA kits, HPLC-MS and western blot analysis were applied to explore the underlying antidepressant mechanisms of rhodioloside. Rhodioloside (20, 40 mg/kg) significantly reversed OBX-induced reduction in sucrose consumption. It was also observed that administration of rhodioloside (20, 40 mg/kg) decreased pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) levels and inhibits nuclear factor-kappa B (NF-kappa B) activation, as well as normalized the monoaminergic system changes in prefrontal cortex (PFC) of OBX rats. These results confirmed the antidepressant-like effect of rhodioloside, which might be primarily based on its up-regulation of the monoaminergic system activity and anti-inflammatory effect. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Zhang, Xu] Chengdu Univ TCM, Clin Med Coll, Chengdu 610075, Peoples R China.
   [Duan, Junguo] Chengdu Univ TCM, Dept Ophthalmol, Chengdu 610075, Peoples R China.
   [Du, Qianming] Nanjing Med Univ, Affiliated Hosp 1, Gen Clin Res Ctr, Nanjing, Jiangsu, Peoples R China.
   [Liu, Chao] Nanjing Med Univ, Affiliated Hosp 1, Dept Pharm, Nanjing, Jiangsu, Peoples R China.
   [Yang, Yan] Third Peoples Hosp Chengdu, Dept Tradit Chinese Med, 82 Qing Long St, Chengdu 610031, Peoples R China.
   [Wang, Jianing] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Neurobiol Lab, Nanjing 210009, Jiangsu, Peoples R China.
   [Duan, Suqian] UCL, London WC1E 6BT, England.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Nanjing Medical University; Nanjing
   Medical University; China Pharmaceutical University; University of
   London; University College London
RP Duan, JG (corresponding author), Chengdu Univ TCM, Dept Ophthalmol, Chengdu 610075, Peoples R China.
EM jgduan2016@163.com
RI ; wang, jianing/LCE-6869-2024
OI , Qianming Du/0000-0002-1092-2899; 
CR Depciuch J., 2015, PHARM REP, V68, P521
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NR 21
TC 22
Z9 26
U1 4
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUL
PY 2016
VL 36
BP 300
EP 304
DI 10.1016/j.intimp.2016.05.008
PG 5
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA DP4GB
UT WOS:000378453300039
PM 27214337
DA 2026-05-27
ER

PT J
AU Saidi, I
   Waffo-Téguo, P
   Ayeb-Zakhama, AEL
   Harzallah-Skhiri, F
   Marchal, A
   Ben Jannet, H
AF Saidi, Ilyes
   Waffo-Teguo, Pierre
   Ayeb-Zakhama, Asma E. L.
   Harzallah-Skhiri, Fethia
   Marchal, Axel
   Ben Jannet, Hichem
TI Phytochemical study of the trunk bark of Citharexylum spinosum L.
   growing in Tunisia: Isolation and structure elucidation of iridoid
   glycosides
SO PHYTOCHEMISTRY
LA English
DT Article
DE Citharexylum spinosum L; Verbenaceae; Phytochemical investigation;
   Iridoid glycosides; Tunispinosides A-D; Phenylethanoid glycosides;
   8,3'-neolignan glycosides; NMR; HPLC; ESI-HRMS
ID PHENYLETHANOID GLYCOSIDES; LIGNAN GLYCOSIDES; GLUCOSIDES; METABOLITES;
   BIOSYNTHESIS; VERBASCOSIDE; VERBENACEAE; LABIATAE; FLOWERS; STEMS
AB A phytochemical investigation of the trunk bark ethyl acetate extract of Citharexylum spinosum L. has led to the isolation of four previously undescribed iridoid glycosides, tunispinosides A-D, and five known phenylethanoid glycosides, verbascoside, leucosceptoside A, martynoside, isoverbascoside and plantainoside C, together with 4-hydroxy-2,6-dimethoxyphenyl 6'-O-vanilloyl-beta-D-glucopyranoside, two 8,3'-neolignan glycosides, plucheosides D-1-D-2, coniferyl aldehyde, vanillic acid, syringic acid, ferulic acid and tyrosol. All compounds were isolated for the first time from C. spinosum. Their isolation was carried out using silica gel column and high performance liquid chromatography (HPLC). Structures were established by spectroscopic means including 1D and 2D NMR experiments, and spectrometric ESI-HRMS analysis. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Saidi, Ilyes; Ben Jannet, Hichem] Univ Monastir, Fac Sci Monastir, Equipe Chim Med & Prod Nat, Lab Chim Heterocycl Prod Nat & React LR11ES39, Ave Environm, Monastir 5019, Tunisia.
   [Waffo-Teguo, Pierre; Marchal, Axel] Univ Bordeaux, ISVV, EA 4577, Unite Rech Enol,CS50008, 210 Chemin Leysotte, F-33882 Villenave Dornon, France.
   [Waffo-Teguo, Pierre; Marchal, Axel] INRA, ISVV, USC Enol 1366, CS 50008, 210 Chemin Leysotte, F-33882 Villenave Dornon, France.
   [Ayeb-Zakhama, Asma E. L.; Harzallah-Skhiri, Fethia] Univ Monastir, Inst Super Biotechnol Monastir, Lab Bioressources Biol Integrat & Valorisat, Ave Tahar Haddad, Monastir 5000, Tunisia.
C3 Universite de Monastir; Universite de Bordeaux; Universite de Bordeaux;
   INRAE; Universite de Monastir
RP Ben Jannet, H (corresponding author), Univ Monastir, Fac Sci Monastir, Equipe Chim Med & Prod Nat, Lab Chim Heterocycl Prod Nat & React LR11ES39, Ave Environm, Monastir 5019, Tunisia.; Waffo-Téguo, P (corresponding author), Univ Bordeaux, ISVV, EA 4577, Unite Rech Enol,CS50008, 210 Chemin Leysotte, F-33882 Villenave Dornon, France.
EM pierre.waffo-teguo@u-bordeaux.fr; hich.benjannet@yahoo.fr
RI ; SAIDI, Ilyes/ITU-9834-2023; ben jannet, hichem/ABA-6598-2021
OI HARZALLAH-Skhiri, Fethia/0000-0003-3474-983X; SAIDI,
   Ilyes/0000-0002-6408-1482; , imen/0000-0002-4396-6978; ben jannet,
   hichem/0000-0001-5858-1803
FU Ministry of Higher Education and Scientific Research of Tunisia
FX The authors are grateful to the Ministry of Higher Education and
   Scientific Research of Tunisia for financial support.
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NR 48
TC 21
Z9 22
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD FEB
PY 2018
VL 146
BP 47
EP 55
DI 10.1016/j.phytochem.2017.11.012
PG 9
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA FU5LW
UT WOS:000423895200006
PM 29223063
DA 2026-05-27
ER

PT J
AU Spreng, S
   Dawid, C
   Dunkel, A
   Hofmann, T
AF Spreng, Stefan
   Dawid, Corinna
   Dunkel, Andreas
   Hofmann, Thomas
TI Quantitation of Key Antioxidants and Their Contribution to the Oxidative
   Stability of Beer
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE antioxidants; beer; flavor stability; hordatines; LC-MS/MS; phenols;
   tachioside
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; PHENOLIC-COMPOUNDS; BITTER COMPOUNDS;
   ACIDS; RED; PROANTHOCYANIDINS; IDENTIFICATION; BARLEY
AB A sensitive high-performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-MS/MSMRM) method, leveraging both technique and internal calibration, was developed for the simultaneous and comprehensive quantitative analysis of 46 antioxidants and antioxidant precursors in different beer types without any cleanup procedure. Combined with their in vitro antioxidant activity, a dose-activity estimation exposed a group of 10 key antioxidants, namely, tryptophan, tyrosine, hordatine A, hordatine B, procyanidin B3, prodelphinidin B3, tachioside (3-methoxy-4-hydroxyphenyl-beta-d-glucopyranoside), (+)-catechin, tyrosol, and ferulic acid. To study the effect of antioxidants in spiking and aging studies, another liquid chromatography-MS (LC-MS)-based method was developed, monitoring markers for oxidation in beer. A positive effect of the antioxidants on the flavor stability at naturally relevant concentrations was shown by a slowing of oxygen-dependent aging reactions highlighted in beer storage trials under oxygen atmosphere. Thereby, a doubling of the natural concentration of all investigated antioxidants in beer revealed a limit inhibition of 67% on the degradation of cis-isocohumulone to hydroxy-cis-alloisocohumulone.
C1 [Spreng, Stefan; Dawid, Corinna; Hofmann, Thomas] Tech Univ Munich, Chair Food Chem & Mol & Sensory Sci, D-85354 Freising Weihenstephan, Germany.
   [Dawid, Corinna; Hofmann, Thomas] Bavarian Ctr Biomol Mass Spectrometry, D-85354 Freising Weihenstephan, Germany.
   [Dunkel, Andreas] Tech Univ Munich, Leibniz Inst Food Syst Biol, D-85354 Freising Weihenstephan, Germany.
C3 Technical University of Munich; Leibniz Association; Leibniz-Institute
   for Food Systems Biology at the Technical University of Munich;
   Technical University of Munich
RP Hofmann, T (corresponding author), Tech Univ Munich, Chair Food Chem & Mol & Sensory Sci, D-85354 Freising Weihenstephan, Germany.; Hofmann, T (corresponding author), Bavarian Ctr Biomol Mass Spectrometry, D-85354 Freising Weihenstephan, Germany.
EM thomas.hofmann@tum.de
RI ; Dunkel, Andreas/PJS-6173-2026
OI Dawid, Corinna/0000-0001-5342-2600; 
FU German Ministry of Economics and Technology; Forschungskreis der
   Ernahrungsindustrie e.V., Bonn) [AiF 17474 N]
FX This research project was supported by the German Ministry of Economics
   and Technology (via AiF) and the FEI (Forschungskreis der
   Ernahrungsindustrie e.V., Bonn), through Project AiF 17474 N. In this
   context, the authors are thankful to Julia Wannenmacher and Martina
   Gastl, who also reviewed the manuscript. They are grateful to Anja
   Beusch and Roman Lang for providing feruloylquinic acid mixture isolated
   from green coffee. Moreover, they thank Michael Dresel for providing
   N-feruloyltyramine, isoxanthohumol, and xanthohumol as analytical
   standards.
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NR 45
TC 2
Z9 2
U1 2
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 16
PY 2024
VL 72
IS 29
BP 16423
EP 16437
DI 10.1021/acs.jafc.4c01000
EA JUL 2024
PG 15
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA ZL5T5
UT WOS:001270032900001
PM 39010731
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Soares, AD
   Tieppo, C
   Soares, LR
   Corsino, J
   Souza, AF
   Garcez, FR
   Garcez, WS
AF Soares, Aloizio de O.
   Tieppo, Caroline
   Soares, Luzinatia Ramos
   Corsino, Joaquim
   Souza, Alex Fonseca
   Garcez, Fernanda R.
   Garcez, Walmir S.
TI IRIDOIDS, TRITERPENES AND OTHER CONSTITUENTS FROM THE TRUNK BARK AND
   FLOWERS OF THE Tabebuia caraiba
SO QUIMICA NOVA
LA Portuguese
DT Article
DE Tabebuia caraiba; Bignoniaceae; iridoids; triterpenes
ID REHMANNIAE RADIX
AB The trunk bark of Tabebuia caraiba Bignoniaceae was found to contain four novel iridoids, 6-O-E-p-coumaroyljioglutin D (2), 6- O-E-p-coumaroyl-3-demethyl-3-O-ethyljioglutin D (3), 6-O- E- p- coumaroyl-1-demethyl-1-O-ethyljioglutin D (4), 7-O-E-p-coumaroyljiofuranaldehyde (5), three known iridoids, including one iridoid glucoside, jioglutin D (1), rehmaglutin D (6), 6-O-E-p-coumaroylcatalpol (7). From the flowers were obtained six triterpenes, betulinic acid (8), olean-12-en-3-one (9), beta-amyrin ( 10), oleanolic acid (11), ursolic acid (12), 3-O-E-p-coumaroylursolic acid (13), 2 alpha-hydroxyursolic acid (14), 6 beta,19 alpha-dihydroxyursolic acid (15), and one phenylethanoid, tyrosol (16), in addition to beta-sitosterol, beta-sitosterol-3-O-beta-D-glucopyranoside and beta-sitosterol-3-O-beta-D-(6'-O-acyl)-glucopyranoside and E-p-coumaric acid. The structures of the isolated compounds were established on the basis of 1D and 2D NMR spectroscopic techniques. The chemical profile of the trunk bark of the plant was determined by HPLC/DAD/HRESIMS and did not present a good correlation with the phytochemical study. It did not detect most of the isolated substances and allowed to propose the presence of some non-isolated compounds.
C1 [Soares, Aloizio de O.] Colegio Mil Campo Grande, BR-79115810 Campo Grande, MS, Brazil.
   [Tieppo, Caroline; Corsino, Joaquim; Souza, Alex Fonseca; Garcez, Fernanda R.; Garcez, Walmir S.] Univ Fed Mato Grosso do Sul, Inst Quim, BR-79070900 Campo Grande, MS, Brazil.
   [Soares, Luzinatia Ramos] Univ Estadual Mato Grosso do Sul, Unidade Univ Campo Grande, BR-79400000 Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Estadual de
   Mato Grosso do Sul
RP Garcez, WS (corresponding author), Univ Fed Mato Grosso do Sul, Inst Quim, BR-79070900 Campo Grande, MS, Brazil.
EM walmir.garcez@ufms.br
RI /H-1081-2013
OI de Farias Soares, Alvaro/0000-0003-0110-3995
CR Ahmad U. V., 1994, HDB NATURAL PRODUCTS, V2
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NR 16
TC 3
Z9 4
U1 0
U2 6
PU SOC BRASILEIRA QUIMICA
PI SAO PAULO
PA CAIXA POSTAL 26037, 05599-970 SAO PAULO, BRAZIL
SN 0100-4042
EI 1678-7064
J9 QUIM NOVA
JI Quim. Nova
PD APR
PY 2020
VL 43
IS 4
BP 399
EP 403
DI 10.21577/0100-4042.20170513
PG 5
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA LY7LF
UT WOS:000540708100002
OA Green Published, Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Su, YQ
   Bai, Y
   Zheng, ZL
   Fan, XY
AF Su, Yuqiang
   Bai, Yan
   Zheng, Zhonglei
   Fan, Xiaoying
TI Rhodioloside inhibits apoptosis of hippocampal neurons exposed to
   sevoflurane via cAMP/PKA signaling pathway
SO TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Cell apoptosis; cAMP/PKA pathway; Hippocampal neurons; Rhodioloside;
   Sevoflurane
ID ANESTHESIA; NEUROTOXICITY; DISEASE; BRAIN
AB Purpose: Neural injury affects patients after using inhalational anesthetics such as sevoflurane. Rhodioloside, a compound which is obtained from the Rhodiola rosea plant has been implicated to be the most commonly used psychostimulant that can improve a range of conditions. The study was aimed at finding the molecular mechanism underlying the Rhodioloside treatment of sevoflurane-injured hippocampal neurons.
   Methods: Main hippocampal neurons, secluded from Sprague Dawley embryonic rats were employed to create an injury model using 3 % sevoflurane. The sevoflurane-injured hippocampal neurons were treated with varying concentrations (10, 20, 40 and 80 mu M/ml) of Rhodioloside to create different experimental groups: RHSD10+SEV, RHSD20+SEV, RHSD40+SEV, RHSD80+SEV, while untreated cells were considered as the Control group. Cell viability was identified using the CCK-8 assay. The CFSE assay was used to verify the promotion function of Rhodioloside on cell differentiation of neurons. FCM assay was employed to determine cell proliferation and apoptosis. Expression levels of apoptosisrelated factors, like Caspase-3, Bcl-2 and Bax were examined by RT-qPCR, while Western blot was used to measure phosphorylation of PKA.
   Results: Rhodioloside stimulated cell viability and prevented cell apoptosis in sevoflurane-injured hippocampal neurons in doses between 10-80 mu M. The apoptosis-inhibitory effect of Rhodioloside was observed to be through cAMP/PKA pathway activation. Also, expression levels of Bcl-2, and PKA were enhanced and the level of Caspase-3 and Bax was reduced in a dose-dependent pattern. The PKA inhibitor reversed the above observation in the 40 mu M Rhodioloside-treatment.
   Conclusion: Rhodioloside promoted cell viability and prevented apoptosis of primary hippocampal neurons injured by sevoflurane, through cAMP/PKA pathway activation. Inhibition of PKA network deteriorated the function of Rhodioloside by stimulating cell apoptosis. Our findings present a novel evidence that Rhodioloside could attenuate neurotoxicity of inhalational anesthetics.
C1 [Su, Yuqiang; Bai, Yan; Zheng, Zhonglei; Fan, Xiaoying] Xian Med Coll, Dept Surg Anesthesia, Affiliated Hosp 2, Xian 710038, Peoples R China.
C3 Xi'an Medical University
RP Fan, XY (corresponding author), Xian Med Coll, Dept Surg Anesthesia, Affiliated Hosp 2, Xian 710038, Peoples R China.
EM dced7848@126.com
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NR 28
TC 0
Z9 0
U1 1
U2 11
PU PHARMACOTHERAPY GROUP
PI BENIN CITY
PA UNIV BENIN, FACULTY PHARMACY, BENIN CITY, 00000, NIGERIA
SN 1596-5996
J9 TROP J PHARM RES
JI Trop. J. Pharm. Res.
PD SEP
PY 2020
VL 19
IS 9
BP 1827
EP 1834
DI 10.4314/tjpr.v19i9.5
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NZ6CR
UT WOS:000577194400005
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, Y
   Guo, XQ
   Wang, GH
   Liu, JD
   Liang, PY
   Wang, H
   Zhu, CY
   Wu, Q
AF Zhang, Yue
   Guo, Xinqing
   Wang, Guohua
   Liu, Jidan
   Liang, Peiyu
   Wang, Huan
   Zhu, Chunyan
   Wu, Qiong
TI Effects of rhodioloside on the neurological functions of rats with total
   cerebral ischemia/reperfusion and cone neuron injury in the hippocampal
   CA1 region
SO PEERJ
LA English
DT Article
DE Rhodioloside; Total cerebral ischemia/reperfusion; Bcl-2/Bax; p53
ID ISCHEMIA; P53; APOPTOSIS; DEATH; INFLAMMATION; TOLERANCE; GERBIL;
   DAMAGE; CELLS
AB Rhodioloside, the main effective constituent of Rhodiola rosea, demonstrates antiaging and antioxidative stress functions and inhibits calcium overloading in cells. These functions imply that rhodioloside may exert protective effects on hippocampal neurons after total cerebral ischemia/reperfusion injury. In this study, male Wistar rat models of total cerebral ischemia were constructed and randomly divided into four groups: sham-operation, ischemia/reperfusion, low-dosage, and high-dosage groups. The result showed that rhodioloside treatment reduced the apoptosis rates of hippocampal neurons and the histological grades of cone cells in the hippocampal CA1 region, but neuronal density was significantly increased. Besides, the protein expressions of Bcl2/Bax and p53 were measured and found Bcl-2/Bax was increased and p53 protein level was reduced. Therefore, rhodioloside might have protective effects on rats with ischemia/reperfusion brain injury.
C1 [Zhang, Yue; Wang, Guohua; Liu, Jidan; Wu, Qiong] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Shaanxi, Peoples R China.
   [Guo, Xinqing] Heze Med Coll, Dept Basic Med, Heze, Peoples R China.
   [Liang, Peiyu; Wang, Huan; Wu, Qiong] Qinghai Univ, Med Coll, Xining, Peoples R China.
   [Zhu, Chunyan] Municipal Hosp Heze, Pharmaceut Sect, Heze, Shandong, Peoples R China.
C3 Northwest A&F University - China; Qinghai University
RP Wu, Q (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Shaanxi, Peoples R China.; Wu, Q (corresponding author), Qinghai Univ, Med Coll, Xining, Peoples R China.; Zhu, CY (corresponding author), Municipal Hosp Heze, Pharmaceut Sect, Heze, Shandong, Peoples R China.
EM zhuchunyan790514@163.co; wuyiong@qhu.edu.cn
RI Wang, Guohua/AAD-8992-2022
OI Zhang, Yue/0000-0003-3568-0395
FU Natural Science Foundation of China [81860762]; Qinghai Fundamental
   Scientific and Technological Research Plan [2018-ZJ-721]; Scientific
   Research Guiding Plan Topic of Qinghai Hygiene Department
   [2018-wjzdx-131]
FX This work was supported by the Natural Science Foundation of China
   (81860762), the Qinghai Fundamental Scientific and Technological
   Research Plan (2018-ZJ-721), and the Scientific Research Guiding Plan
   Topic of Qinghai Hygiene Department (2018-wjzdx-131). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 31
TC 14
Z9 17
U1 2
U2 11
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD NOV 9
PY 2020
VL 8
AR e10056
DI 10.7717/peerj.10056
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OO7ZB
UT WOS:000587593100001
PM 33240590
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sayed, HM
   Ahmed, AS
   Khallaf, IS
   Qayed, WS
   Mohammed, AF
   Farghaly, HSM
   Asem, A
AF Sayed, Hanaa M.
   Ahmed, Amany S.
   Khallaf, Iman SA.
   Qayed, Wesam S.
   Mohammed, Anber F.
   Farghaly, Hanan S. M.
   Asem, Ayman
TI Phytochemical investigation, molecular docking studies and DFT
   calculations on the antidiabetic and cytotoxic activities of Gmelina
   philippensis CHAM
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE ?-Amylase; ?-glucosidase; Gmelina philippensis; Gmelinol; Iridoids;
   Protein kinases
ID ACYLATED IRIDOID GLYCOSIDES; MEDICINAL-PLANTS; ANTIFUNGAL ACTIVITY; PART
   1; ARBOREA; CONSTITUENTS; LIGNANS; HEARTWOOD; TOXICITY; GLUCOSIDASE
AB Ethnopharmacological relevance: Gmelina philippensis CHAM is an ornamental plant that is distributed in South Asia and warm regions of the Mediterranean area. The plant is traditionally applied in folk medicine for the treatment of diabetes. Aim of the study: To evaluate the cytotoxic and the antidiabetic activities of the ethanolic extract of G. philippensis aerial parts. To isolate the metabolite(s) responsible for these activities and to elucidate the mechanism of action by molecular docking study.Materials and methods: Compounds (1-11) were isolated using various chromatographic techniques and their structures were determined by NMR spectroscopic and mass spectrometric analysis. The cytotoxic effect was tested using viability test and MTT assay. Antidiabetic activity was evaluated by measuring the inhibitory activity of the ethanolic extracts and compounds against alpha-glucosidase and alpha-amylase activities. Modeling and docking simulations were performed using Molecular Operating Environment software and the crystal structure of protein kinases CDK2, (1PYE) and AKT1 (4GV1), in addition to alpha-glucosidase (3TOP) and alpha-amylase (2QV4).Results: Compounds 2, 3 and 8 were isolated for the first time from the plant and identified as: gmelinol (2), apigenin (3) and tyrosol (8). While beta-sitosterol-3-O- beta-D-glucopyranoside (4) vicenin-II (7), rhoifolin (9), isorhoifolin (11) were isolated for the first time from the genus, along with and the new iridoid 6-O-alpha-L-(2 ''-Obenzoyl-4 ''-O-trans-p-methoxycinnamoyl)rhamnopyranosyl-1 alpha- beta-D-glucopyranoside catalpolgenin (6). In addition, to the previously reported compounds: mixture of beta -sitosterol and stigmasterol (1), and 6- O- alpha-L(2 '',3 '',4 ''-tri-O -benzoyl)rhamnopyranosylcatalpol (5) and 6-O-alpha-L-(2 ''-O-trans-p-methoxycinnamoyl)rhamnopyranosylcatalpol (10). The cytotoxic activity against hepatocellular carcinoma (HepG-2) cell lines for compounds 2, 5, 7, 9 and 11 was conducted using cisplatin as a standard. Gmelinol (2) exhibited strong cytotoxic activity against HepG-2 cell lines with IC 50 value of 3.6 +/- 0.1 mu g/ml which is more potent than the standard cisplatin IC 50 = 8.7 +/- 0.9 mu g/ml. Molecular modeling of 2 against diverse targets of protein kinases suggested that CDK-2 and AKT-1 could be the dual probable kinase targets for its cytotoxic action. Compound 2 showed alpha-amylase inhibition activity with IC 50 value of 60.9 (mu g/ml) while, compounds 5 showed strong alpha-glucosidase inhibition activity with IC 50 values of 41.7 (mu g/ml) compared to acarbose with IC 50 value of 34.7, 30.6 (mu g/ml). Molecular docking of compounds 2 and 5 on alpha-glucosidase (3TOP) and alpha-amylase (2QV4) enzymes revealed high binding affinity and active site interactions comparable to native ligand acarbose. Conclusion: The ethanolic extract of G. philippensis CHAM aerial parts is effective against HepG-2 cell lines, alpha-amylase and alpha-glucocidase activities. Biologically guided isolation indicated that compounds 2 and 5 are responsible for these activities. These results were supported by DMF calculations that detected the molecular areas responsible for protein interactions shown via docking studies.
C1 [Sayed, Hanaa M.; Ahmed, Amany S.; Asem, Ayman] Assiut Univ, Fac Pharm, Pharmacognosy Dept, Assiut 71526, Egypt.
   [Ahmed, Amany S.] Sphinx Univ, Fac Pharm, New Assiut, Egypt.
   [Khallaf, Iman SA.] Menoufia Univ, Fac Pharm, Pharmacognosy & Nat Prod Dept, Shibin Al Kawm 32511, Egypt.
   [Qayed, Wesam S.] Assiut Univ, Fac Pharm, Dept Med Chem, Assiut 71526, Egypt.
   [Mohammed, Anber F.] Assiut Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Assiut 71526, Egypt.
   [Farghaly, Hanan S. M.] Assiut Univ, Fac Med, Pharmacol Dept, Assiut 71526, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University; Sphinx University;
   Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Assiut University; Egyptian Knowledge Bank (EKB); Assiut
   University; Egyptian Knowledge Bank (EKB); Assiut University
RP Khallaf, IS (corresponding author), Menoufia Univ, Fac Pharm, Pharmacognosy & Nat Prod Dept, Shibin Al Kawm 32511, Egypt.
EM iman.khallaf123@phrm.menofia.edu.eg
RI ; S. Qayed, Wesam/AAF-7287-2021; Farghaly, Hanan/AAC-8303-2019;
   Mohammed, Anber/HME-2701-2023
OI Khallaf, Iman/0000-0002-3267-3387; S. Qayed, Wesam/0000-0001-7220-5628; 
FU Faculty of Pharmacy, Assiut University, Egypt
FX The authors gratefully acknowledge Dr. Reda Ahmed (Graduate School of
   Science and Engineering, Department of Biochemical Engi- neering,
   Yamagata, Yamagata University, 992-8510, Japan) for HRMS measurement.
   Financial support from Faculty of Pharmacy, Assiut University, Egypt is
   gratefully acknowledged.
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NR 74
TC 12
Z9 17
U1 2
U2 38
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAR 1
PY 2023
VL 303
AR 115938
DI 10.1016/j.jep.2022.115938
EA NOV 2022
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 7M8OM
UT WOS:000906910800001
PM 36410572
DA 2026-05-27
ER

PT J
AU Ha, XQ
   Yang, B
   Hou, HJ
   Cai, XL
   Xiong, WY
   Wei, XP
AF Ha, Xiao-Qin
   Yang, Bo
   Hou, Huai-Jing
   Cai, Xiao-Ling
   Xiong, Wan-Yuan
   Wei, Xu-Pan
TI Protective effect of rhodioloside and bone marrow mesenchymal stem cells
   infected with HIF-1-expressing adenovirus on acute spinal cord injury
SO NEURAL REGENERATION RESEARCH
LA English
DT Article
DE acute spinal cord injury; adenovirus; adenovirus gene IX; bone marrow
   mesenchymal stem cells; combined behavioral score scale; HIF-1 alpha;
   nerve regeneration; nerve repair; Rhodiola rosea; Sry
ID RECOVERY; RATS; TRANSPLANTATION; AXONS; ACID
AB Rhodioloside has been shown to protect cells from hypoxia injury, and bone marrow mesenchymal stem cells have a good effect on tissue repair. To study the effects of rhodioloside and bone marrow mesenchymal stem cells on spinal cord injury, a rat model of spinal cord injury was established using the Infinite Horizons method. After establishing the model, the rats were randomly divided into five groups. Rats in the control group were intragastrically injected with phosphate buffered saline (PBS) (5 mu L). PBS was injected at 6 equidistant points around 5 mm from the injury site and at a depth of 5 mm. Rats in the rhodioloside group were intragastrically injected with rhodioloside (5 g/kg) and intramuscularly injected with PBS. Rats in the mesenchymal stem cell (MSC) group were intramuscularly injected with PBS and intramuscularly with MSCs (8 x 10(6)/mL in a 50-mu L cell suspension). Rats in the Ad-HIF-MSC group were intragastrically injected with PBS and intramuscularly injected with HIF-1 adenovirus-infected MSCs. Rats in the rhodioloside + Ad-HIF-MSC group were intramuscularly injected with MSCs infected with the HIF-1 adenovirus and intragastrically injected with rhodioloside. One week after treatment, exercise recovery was evaluated with a modified combined behavioral score scale. Hematoxylin-eosin staining and Pischingert's methylene blue staining were used to detect any histological or pathological changes in spinal cord tissue. Levels of adenovirus IX and Sry mRNA were detected by real-time quantitative polymerase chain reaction and used to determine the number of adenovirus and mesenchymal stem cells that were transfected into the spinal cord. Immunohistochemical staining was applied to detect HIF-1 protein levels in the spinal cord. The results showed that: (1) compared with the other groups, the rhodioloside + Ad-HIF-MSC group exhibited the highest combined behavioral score (P < 0.05), the most recovered tissue, and the greatest number of neurons, as indicated by Pischingert's methylene blue staining. (2) Compared with the PBS group, HIF-1 protein expression was greater in the rhodioloside group (P < 0.05). (3) Compared with the Ad-HIF-MSC group, Sry mRNA levels were higher in the rhodioloside + Ad-HIF-MSC group (P < 0.05). These results confirm that rhodioloside combined with bone marrow mesenchymal stem cells can promote the recovery of spinal cord injury and activate the HIF-1 pathway to promote the survival of bone marrow mesenchymal stem cells and repair damaged neurons within spinal cord tissue. This experiment was approved by the Animal Ethics Committee of Gansu University of Traditional Chinese Medicine, China (approval No. 2015KYLL029) in June 2015.
C1 [Ha, Xiao-Qin] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China.
   [Yang, Bo] Lanzhou Mil Area Command, Dept Clin Lab, Lanzhou Gen Hosp, Lanzhou, Gansu, Peoples R China.
   [Yang, Bo; Hou, Huai-Jing; Xiong, Wan-Yuan; Wei, Xu-Pan] Gansu Univ Tradit Chinese Med, Sch Clin Med, Lanzhou, Gansu, Peoples R China.
   [Cai, Xiao-Ling] Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Gansu, Peoples R China.
C3 Lanzhou University; Gansu University of Chinese Medicine; Lanzhou
   University of Technology
RP Ha, XQ (corresponding author), Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China.; Yang, B (corresponding author), Lanzhou Mil Area Command, Dept Clin Lab, Lanzhou Gen Hosp, Lanzhou, Gansu, Peoples R China.; Yang, B; Hou, HJ (corresponding author), Gansu Univ Tradit Chinese Med, Sch Clin Med, Lanzhou, Gansu, Peoples R China.
EM haxiaoqin2013@163.com; 1349151062@qq.com; 757097029@qq.com
RI Cai, Xiaoling/AFR-4880-2022; /AAH-4276-2020
FU National High Technology Research and Development Program of China (863
   Program) [2015CB755400]
FX This study was supported by the National High Technology Research and
   Development Program of China (863 Program), No. 2015CB755400 (to XQH).
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NR 34
TC 17
Z9 19
U1 4
U2 70
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1673-5374
EI 1876-7958
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD APR
PY 2020
VL 15
IS 4
BP 690
EP 696
DI 10.4103/1673-5374.266920
PG 7
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA JW7OL
UT WOS:000503237500015
PM 31638093
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhen, LL
   Hou, MT
   Wang, SB
AF Zhen, Lingling
   Hou, Mingtong
   Wang, Shengbao
TI Salidroside attenuates sepsis-induced acute lung injury by inhibiting
   ferroptosis-dependent pathway
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Article
DE Acute lung injury; Arachidonic acid; Ferroptosis; Lipid metabolism;
   Rhodioloside; Sepsis
ID PROTECTS
AB Sepsis triggers a systemic inflammatory response that can lead to acute lung injury (ALI). Salidroside (SAL) has many pharmacological activities such as antiinflammatory and anti-oxidation. The objective of the study was to explore the mechanism of SAL on ALI caused by sepsis. A model of ALI in septic mice was established by cecal ligation and puncture. Following SAL treatment, the effect of SAL on the ferroptosis pathway in mice was analyzed. The pathological damage of lung tissue, the levels of inflammatory factors and apoptosis in bronchoalveolar lavage fluid (BALF) of mice were evaluated, and the changes of gene expression level and metabolite content abundance were explored by combining transcriptomics and metabolomics analysis. The effect of SAL on ferroptosis in mice with lung injury was observed by intraperitoneal injection of ferroptosis activator Erastin or ferroptosis inhibitor Ferrostatin-1 to promote or inhibit ferroptosis in mice. SAL significantly alleviated the pathological damage of lung tissue, decreased the number of TUNEL positive cells and the levels of TNF-alpha, IL-1 beta, IL-6 in BALF, and increased the level of IL10 in lung injury mice. Moreover, the Fe2+ content and malondialdehyde decreased significantly, the reactive oxygen species and glutathione content increased significantly, and the arachidonic acid metabolites 20-hydroxyeicosatetraenoic acid (20HETE), (5Z, 8Z, 10E, 14Z)-12-Oxoeicosa-5,8,10,14-tetraenoic acid (12-OxOETE), (5Z, 8Z, 10E, 14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid (12(S)-HETE), (5Z, 8Z, 14Z)-11,12-Dihydroxyeicosa-5,8,14-trienoic acid (11,12-DHET), (5Z, 11Z, 14Z)-8,9Dihydroxyeicosa-5,11,14-trienoic acid, Leukotriene B4, Leukotriene D4 were significantly up-regulated after SAL treatment. Salidroside alleviates ALI caused by sepsis by inhibiting ferroptosis.
C1 [Zhen, Lingling] Lanzhou Univ, Lanzhou Univ Second Hosp, Intens Care Unit, Lanzhou 730030, Gansu, Peoples R China.
   [Hou, Mingtong; Wang, Shengbao] Lanzhou Univ, Clin Med Sch 2, Lanzhou 730030, Gansu, Peoples R China.
   [Hou, Mingtong; Wang, Shengbao] Lanzhou Univ, Lanzhou Univ Second Hosp, Emergency Ctr, Lanzhou 730030, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University; Lanzhou University
RP Wang, SB (corresponding author), Lanzhou Univ, Clin Med Sch 2, Lanzhou 730030, Gansu, Peoples R China.; Wang, SB (corresponding author), Lanzhou Univ, Lanzhou Univ Second Hosp, Emergency Ctr, Lanzhou 730030, Gansu, Peoples R China.
EM wangshengbao@lzu.edu.cn
FU Second Hospital of Lanzhou University "Cuiying Science and Technology
   Innovation" Program [CY2020-MS06]; Natural Science Foundation of Gansu
   Province [20JR10RA724]; Lanzhou Science and Technology Development
   Program [2020-ZD-91]
FX The Second Hospital of Lanzhou University "Cuiying Science and
   Technology Innovation" Program (CY2020-MS06) , Natural Science
   Foundation of Gansu Province (20JR10RA724) , Lanzhou Science and
   Technology Development Program (2020-ZD-91) .
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U2 7
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD NOV
PY 2024
VL 28
IS 6
BP 549
EP 558
DI 10.4196/kjpp.2024.28.6.549
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA U4I8S
UT WOS:001411460800005
PM 39467718
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zheng, ZR
   Wang, RY
   Zhao, Y
   Zhang, P
   Xie, D
   Peng, SJ
   Li, RX
   Zhang, JE
AF Zheng, Zhirui
   Wang, Ruyi
   Zhao, Yu
   Zhang, Pei
   Xie, Dong
   Peng, Shoujiao
   Li, Ruixiang
   Zhang, Jiange
TI Salidroside Derivative SHPL-49 Exerts Anti-Neuroinflammatory Effects by
   Modulating Excessive Autophagy in Microglia
SO CELLS
LA English
DT Article
DE ischemic stroke; autophagy; neuroinflammation; microglia; rhodioloside
   derivative
ID NF-KAPPA-B; DIFFERENTIATION; INFLAMMATION; MECHANISM; INJURY; SYSTEM;
   BRAIN
AB The neuroinflammation triggered by cellular demise plays a pivotal role in ameliorating the injury associated with ischemic stroke, which represents a significant global burden of mortality and disability. The compound SHPL-49, a derivative of rhodioloside, was discovered by our research team and has previously demonstrated neuroprotective effects in rats with ischemic stroke. This study aimed to elucidate the underlying mechanisms of SHPL-49's protective effects. Preliminary investigations revealed that SHPL-49 effectively alleviates PMCAO-induced neuroinflammation. Further studies indicated that SHPL-49 downregulates the expression of the lysosomal protein LAMP-2 and reduces lysosomal activity, impeding the fusion of lysosomes and autophagosomes, thus inhibiting excessive autophagy and increasing the expression levels of the autophagy proteins LC3-II and P62. Furthermore, SHPL-49 effectively reverses the NF-kappa B nuclear translocation induced by the autophagy inducer rapamycin, significantly lowering the expression levels of the inflammatory factors IL-6, IL-1 beta, and iNOS. In a co-culture system of BV2 and PC12 cells, SHPL-49 enhanced PC12 cell viability by inhibiting excessive autophagy in BV2 cells and reducing the ratio of apoptotic proteins Bax and BCL-2. The overall findings suggest that SHPL-49 exerts its neuroprotective effects through the inhibition of excessive autophagy and the suppression of the NF-kappa B signaling pathway in microglia, thereby attenuating neuroinflammation.
C1 [Zheng, Zhirui; Wang, Ruyi; Zhao, Yu; Zhang, Pei; Xie, Dong; Peng, Shoujiao; Li, Ruixiang; Zhang, Jiange] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit, Res Ctr Chiral Drugs, Chinese Med IRI, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Zhang, JE (corresponding author), Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit, Res Ctr Chiral Drugs, Chinese Med IRI, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China.
EM jgzhang@shutcm.edu.cn
RI ; Wang, Ruyi/KYP-8085-2024; Li, Ruixiang/IUN-3788-2023
OI Peng, Shoujiao/0000-0003-3086-8372; 
FU Traditional Chinese and Western Medicine Collaborative Guidance Project
   of Integrated Hospital from Shanghai Municipal Health
   Commission/Shanghai Municipal Administration of Traditional Chinese
   Medicine; Shanghai Science and Technology Development Fund from Central
   Leading Local Government [YDZX20223100001004]; Renowned Traditional
   Chinese Medicine Academic Experience Inheritance, Innovation, Quality
   Improvement and Upgrading Project from Shanghai Municipal Health
   Commission/Shanghai Municipal Administration of Traditional Chinese
   Medicine [A1-C24-800-0302];  [ZXXT-202303]
FX This work was supported by Traditional Chinese and Western Medicine
   Collaborative Guidance Project of Integrated Hospital from Shanghai
   Municipal Health Commission/Shanghai Municipal Administration of
   Traditional Chinese Medicine (ZXXT-202303), Shanghai Science and
   Technology Development Fund from Central Leading Local Government
   (YDZX20223100001004), Renowned Traditional Chinese Medicine Academic
   Experience Inheritance, Innovation, Quality Improvement and Upgrading
   Project from Shanghai Municipal Health Commission/Shanghai Municipal
   Administration of Traditional Chinese Medicine (A1-C24-800-0302).
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NR 47
TC 2
Z9 2
U1 1
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR 13
PY 2025
VL 14
IS 6
AR 425
DI 10.3390/cells14060425
PG 21
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0OD5L
UT WOS:001452011000001
PM 40136674
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tolonen, A
   Pakonen, M
   Hohtola, A
   Jalonen, J
AF Tolonen, A
   Pakonen, M
   Hohtola, A
   Jalonen, J
TI Phenylpropanoid glycosides from Rhodiola rosea
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Rhodiola rosea L.; Crassulaceae; phenylpropanoid; glycoside
ID UNDERGROUND PART; SPECTRA; EXTRACT; TUMORS
AB Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1 (6) and 4-methoxy-cinnamyl-O-beta-D-glueopyranoside (7), four compounds were isolated from aqueous methanol extract of the plant and identified as cinnamyl-(6'-O-beta-xylopyranosyl)-O-beta-glucopyranoside (8), 4-methoxy-cinnamyl-(6'-O-alpha-arabinopyranosyl)-O-beta-glucopyranoside (9), picein (10) and benzyl-O-beta-glucopyranoside (11) by UV, MS and NMR methods. Compounds 8 and 9 are new natural compounds whereas compounds 10 and 11 were isolated first time from R. rosea. Also the compounds 6 and 7 are isolated earlier only from the callus cultures of the plant but not from the differentiated plant.
C1 Oulu Univ, Dept Chem, Oulu 90014, Finland.
   Oulu Univ, Dept Biol, Oulu 90014, Finland.
C3 University of Oulu; University of Oulu
RP Tolonen, A (corresponding author), Oulu Univ, Dept Chem, POB 3000, Oulu 90014, Finland.
EM ari.tolonen@oulu.fi
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NR 21
TC 75
Z9 88
U1 2
U2 82
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD APR
PY 2003
VL 51
IS 4
BP 467
EP 470
PG 4
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 663FH
UT WOS:000181995200026
PM 12673010
OA Bronze
DA 2026-05-27
ER

PT J
AU Che, YJ
   Chen, YY
   Wang, ZW
   Zheng, SH
   Xing, K
   Yuan, S
   Zhong, XH
AF Che, Yanjia
   Chen, Yuanyang
   Wang, Zhiwei
   Zheng, Sihao
   Xing, Kai
   Yuan, Shun
   Zhong, Xiaohan
TI The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival
   by Inhibiting DC Maturation by Promoting Mitochondrial Fusion
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID WORKING FORMULATION; DENDRITIC CELLS; PULMONARY-HYPERTENSION; IN-VITRO;
   SALIDROSIDE; HEART; STANDARDIZATION; NOMENCLATURE; DIAGNOSIS;
   TRANSPLANTATION
AB Despite being the gold-standard treatment for end-stage heart disease, heart transplantation is associated with acute cardiac rejection within 1 year of transplantation. The continuous application of immunosuppressants may cause side effects such as hepatic and renal toxicity, infection, and malignancy. Developing new pharmaceutical strategies to alleviate acute rejection after heart transplantation effectively and safely is of critical importance. In this study, we performed a murine model of MHC-full mismatch cardiac transplantation and showed that the combination of Rhodosin (Rho) and mycophenolate mofetil (MMF) could prevent acute rejection and oxidative stress injury and prolong the survival time of murine heart transplants. The use of Rho plus MMF in allografts improved the balance of Tregs/Teff cells, which had a protective effect on allotransplantation. We also isolated bone marrow-derived dendritic cells (BMDCs) and determined that Rho inhibited DC maturation by promoting mitochondrial fusion mainly through the mitochondrial fusion-related protein MFN1. Herein, we demonstrated that Rho, an active ingredient isolated from the plant Rhodiola rosea with antioxidant and anti-inflammatory activities, could efficiently alleviate acute rejection and significantly prolong murine heart allograft survival when used with a low dose of MMF. More importantly, we found that Rho restrained DC maturation by promoting mitochondrial fusion and decreasing reactive oxygen species (ROS) levels, which then alleviated acute rejection in murine cardiac transplantation. Interestingly, as a novel immunosuppressant, Rho has almost no side effects compared with other traditional immunosuppressants. Taken together, these results suggest that Rho has good clinical auxiliary applications as an effective immunosuppressant and antioxidant, and this study provides an efficient strategy to overcome the side effects of immunosuppressive agents that are currently used in organ transplantation.
C1 [Che, Yanjia; Chen, Yuanyang; Wang, Zhiwei; Zheng, Sihao; Xing, Kai; Yuan, Shun; Zhong, Xiaohan] Wuhan Univ, Renmin Hosp, Dept Cardiovasc Surg, Wuhan 430060, Peoples R China.
   [Che, Yanjia; Chen, Yuanyang; Zheng, Sihao; Xing, Kai; Yuan, Shun; Zhong, Xiaohan] Wuhan Univ, Renmin Hosp, Cardiovasc Surg Lab, Wuhan 430060, Peoples R China.
   [Che, Yanjia; Chen, Yuanyang; Wang, Zhiwei; Zheng, Sihao; Xing, Kai; Yuan, Shun; Zhong, Xiaohan] Wuhan Univ, Renmin Hosp, Cent Lab, Wuhan 430060, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Wang, ZW (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiovasc Surg, Wuhan 430060, Peoples R China.; Wang, ZW (corresponding author), Wuhan Univ, Renmin Hosp, Cent Lab, Wuhan 430060, Peoples R China.
EM 2015302180011@whu.edu.cn; 2019203020064@whu.edu.cn;
   wangzhiwei@whu.edu.cn; 2019203020048@whu.edu.cn; xingkai@whu.edu.cn;
   23586343163@qq.com; 2015302180129@whu.edu.cn
OI 邢, 凯/0000-0001-7087-0157; yanjia, che/0000-0002-0930-6503
FU National Natural Science Foundation of China [82070481]
FX AcknowledgmentsThis work was supported by the National Natural Science
   Foundation of China (Grant No. 82070481).
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NR 50
TC 3
Z9 3
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 9
PY 2022
VL 2022
AR 7260305
DI 10.1155/2022/7260305
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3F7GE
UT WOS:000830832300006
PM 35855862
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Simon, K
   Jones, PG
   Lindel, T
AF Simon, Kristina
   Jones, Peter G.
   Lindel, Thomas
TI Total Syntheses of Rhodiolosides A and D and of Sachalinols A-C
SO EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
LA English
DT Article
DE Glucosylation; Natural products; Rosiridol; Terpenoids; Oxygen
   heterocycles; Total synthesis
ID ABSOLUTE-CONFIGURATION; STEREOCHEMISTRY; MONOTERPENES; METABOLITES;
   ANALOGS
AB The glucosylated monoterpenoids (-)-rhodioloside A and (-)-rhodioloside D from the roseroot (Rhodiola rosea) have been synthesized for the first time. Glucosylation with tetrapivaloylglucosyl bromide proved superior to the use of tetraacetylglucosyl bromide or glucosyl iodides. Acid-catalyzed cyclization of a homoglycidol-type geraniol derivative afforded the monoterpenoid tetrahydrofuran (+)-sachalinol C from Rhodiola sachalinensis. The absolute configuration of (+)-sachalinol C requires revision. (-)-Sachalinol A and (-)-sachalinol B were also obtained.
C1 [Simon, Kristina; Jones, Peter G.; Lindel, Thomas] Tech Univ Carolo Wilhelmina Braunschweig, Inst Organ, D-38106 Braunschweig, Germany.
   [Simon, Kristina; Jones, Peter G.; Lindel, Thomas] Tech Univ Carolo Wilhelmina Braunschweig, Inst Inorgan, D-38106 Braunschweig, Germany.
   [Simon, Kristina; Jones, Peter G.; Lindel, Thomas] Tech Univ Carolo Wilhelmina Braunschweig, Inst Analyt Chem, D-38106 Braunschweig, Germany.
C3 Braunschweig University of Technology; Braunschweig University of
   Technology; Braunschweig University of Technology
RP Lindel, T (corresponding author), Tech Univ Carolo Wilhelmina Braunschweig, Inst Organ, Hagenring 30, D-38106 Braunschweig, Germany.
EM th.lindel@tu-bs.de
RI Lindel, Thomas/AAM-8929-2021
OI Lindel, Thomas/0000-0002-7551-5266
FU Deutsche Forschungsgemeinschaft [Li597/4-1]
FX This work was supported by the Deutsche Forschungsgemeinschaft
   (Li597/4-1). Henning Kuhz is thanked for laboratory assistance. We also
   thank Merck KGaA (Darmstadt, Germany) for a generous gift of
   chromatography materials. BASF AG (Ludwigshafen, Germany) and Honeywell
   Specialty Chemicals Seelze GmbH (Seelze, Germany) are thanked for the
   donation of solvents.
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NR 37
TC 6
Z9 6
U1 0
U2 17
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1434-193X
EI 1099-0690
J9 EUR J ORG CHEM
JI Eur. J. Org. Chem.
PD MAR
PY 2011
VL 2011
IS 8
BP 1493
EP 1503
DI 10.1002/ejoc.201001315
PG 11
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC); Current Chemical Reactions (CCR-EXPANDED)
SC Chemistry
GA 731SH
UT WOS:000288129100012
DA 2026-05-27
ER

PT J
AU Zhao, H
   Zhang, Y
   Liu, B
   Meng, K
   Wang, CY
AF Zhao, Heng
   Zhang, Yang
   Liu, Bo
   Meng, Ke
   Wang, Chunyan
TI Effects of salidroside on the protection of diabetic encephalopathy and
   improvement of abilities of learning and memory in rat
SO JOURNAL OF MEDICINAL PLANTS RESEARCH
LA English
DT Article
DE Diabetes mellitus; salidroside; hippocampus; Morris water maze tests;
   oxidative stress; signal pathway
AB Salidroside, a phenol glycoside isolated from Rhodiola rosea, has been reported to have many pharmacological properties, among which are the protective effects against neuronal death. Salidroside has the best pharmacological effects at the concentration of 50 mg/kg Salidroside (po) for rodents. A diabetic encephalopathy rat model has been generated in this research. After treating with salidroside, the blood glucose reduced and body weight increased in rats. Morris water maze test indicated that salidroside could improve memory and learning ability, because it can protect the brain, promote neurons growth and balance neuron growth factors. Salidroside can also keep biochemistry markers and morphology normal in hippocampus. All these suggest that salidroside may be a potential drug for the treatment of diabetic encephalopathy and other nervous system diseases.
C1 [Zhao, Heng; Wang, Chunyan] Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
   [Zhang, Yang] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China.
   [Liu, Bo] Jilin Univ, Hosp 3, Changchun 130033, Peoples R China.
   [Meng, Ke] Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University
RP Wang, CY (corresponding author), Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
EM chunyan8364@yahoo.cn
FU Jilin science project [200705187]
FX The authors gratefully acknowledge the financial support provided by
   Jilin science project support (200705187).
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NR 20
TC 4
Z9 4
U1 0
U2 17
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0875
J9 J MED PLANTS RES
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PD NOV 23
PY 2011
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IS 27
BP 6328
EP 6335
DI 10.5897/JMPR11.1009
PG 8
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 882OK
UT WOS:000299573100010
OA gold
DA 2026-05-27
ER

PT J
AU Lai, WF
   Luo, R
   Tang, YH
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AF Lai, Wenfang
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   Tang, Yuheng
   Yu, Zhengshuang
   Zhou, Binbin
   Yang, Zelin
   Brown, John
   Hong, Guizhu
TI Salidroside directly activates HSC70, revealing a new role for HSC70 in
   BDNF signalling and neurogenesis after cerebral ischemia
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE BDNF; heat shock cognate 71-kDa protein; neurogenesis; Rhodiola
   crenulata; salidroside; stroke
ID SUBVENTRICULAR ZONE; ARTERY OCCLUSION; SMALL MOLECULES; WATER-MAZE; RAT;
   CELLS; NEUROPROTECTION; DIFFERENTIATION; IDENTIFICATION; EXPRESSION
AB Salidroside, a principal bioactive component of Rhodiola crenulata, is neuroprotective across a wide time window in stroke models. We investigated whether salidroside induced neurogenesis after cerebral ischemia and aimed to identify its primary molecular targets. Rats, subjected to transient 2 h of middle cerebral artery occlusion (MCAO), received intraperitoneal vehicle or salidroside +/- intracerebroventricular HSC70 inhibitor VER155008 or TrkB inhibitor ANA-12 for up to 7 days. MRI, behavioural tests, immunofluorescent staining and western blotting measured effects of salidroside. Reverse virtual docking and enzymatic assays assessed interaction of salidroside with purified recombinant HSC70. Salidroside dose-dependently decreased cerebral infarct volumes and neurological deficits, with maximal effects by 50 mg/kg/day. This dose also improved performance in beam balance and Morris water maze tests. Salidroside significantly increased BrdU(+)/nestin(+), BrdU(+)/DCX+, BrdU(+)/NeuN(+), BrdU(-)/NeuN(+) and BDNF+ cells in the peri-infarct cortex, with less effect in striatum and no significant effect in the subventricular zone. Salidroside was predicted to bind with HSC70. Salidroside dose-dependently increased HSC70 ATPase and HSC70-dependent luciferase activities, but it did not activate HSP70. HSC70 immunoreactivity concentrated in the peri-infarct cortex and was unchanged by salidroside. However, VER155008 prevented salidroside-dependent increases of neurogenesis, BrdU(-)/NeuN(+) cells and BDNF(+ )cells in peri-infarct cortex. Salidroside also increased BDNF protein and p-TrkB/TrkB ratio in ischemic brain, changes prevented by VER155008 and ANA-12, respectively. Additionally, ANA-12 blocked salidroside-dependent neurogenesis and increased BrdU(-)/NeuN(+) cells in the peri-infarct cortex. Salidroside directly activates HSC70, thereby stimulating neurogenesis and neuroprotection via BDNF/TrkB signalling after MCAO. Salidroside and similar activators of HSC70 might provide clinical therapies for ischemic stroke.
   Salidroside induces cortical neurogenesis after stroke by directly activating HSC70, which triggers BDNF/TrkB signalling. image
C1 [Lai, Wenfang; Luo, Rui; Tang, Yuheng; Yu, Zhengshuang; Zhou, Binbin; Yang, Zelin; Brown, John; Hong, Guizhu] Fujian Univ Tradit Chinese Med, Coll Pharmacol, Fuzhou, Peoples R China.
   [Hong, Guizhu] Fujian Univ Tradit Chinese Med, Coll Pharmacol, 1 Qiuyang Rd, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine
RP Hong, GZ (corresponding author), Fujian Univ Tradit Chinese Med, Coll Pharmacol, 1 Qiuyang Rd, Fuzhou, Peoples R China.
EM guizhuhong@fjtcm.edu.cn
OI Hong, Guizhu/0000-0003-3932-4777
FU National Natural Science Foundation of China; Natural Science Foundation
   of Fujian Province, China [2021J02014, 2020J01727, 2019J01345]; 
   [81973503];  [82174001]
FX The authors thank the staff of the Animal Centre of the Fujian
   University of Traditional Chinese Medicine for their technical support.
   This work was supported by the National Natural Science Foundation of
   China (Project 81973503, 82174001) and the Natural Science Foundation of
   Fujian Province, China (Project 2021J02014, 2020J01727, 2019J01345).
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NR 64
TC 10
Z9 13
U1 8
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2024
VL 38
IS 6
BP 2619
EP 2640
DI 10.1002/ptr.8178
EA MAR 2024
PG 22
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UL6N1
UT WOS:001185468900001
PM 38488455
DA 2026-05-27
ER

PT J
AU Guo, N
   Zhu, MX
   Han, XJ
   Sui, D
   Wang, Y
   Yang, Q
AF Guo, Na
   Zhu, Meixuan
   Han, Xuejiao
   Sui, Dan
   Wang, Yang
   Yang, Qian
TI The Metabolism of Salidroside to Its Aglycone p-Tyrosol in Rats
   following the Administration of Salidroside
SO PLOS ONE
LA English
DT Article
ID TANDEM MASS-SPECTROMETRY; N-TYROSOL; IN-VIVO; GASTROINTESTINAL-TRACT;
   TISSUE DISTRIBUTION; DIETARY FLAVONOIDS; SMALL-INTESTINE; GLYCOSIDES;
   PLASMA; DEGLYCOSYLATION
AB Salidroside is one of the major phenolic glycosides in Rhodiola, which has been reported to possess various biological activities. In the present study the in vivo deglycosylation metabolism of salidroside was investigated and its aglycone p-tyrosol but not the original salidroside was identified as the main form in rat tissues following the administration of salidroside. After the i.v. administration of salidroside at a dose of 50 mg/kg in rats, salidroside was quantified only in the liver, kidney and heart tissues. The highest level of p-tyrosol was detected in the heart, followed by the spleen, kidney, liver and lungs, in order. Salidroside was detected only in the liver, in contrast, p-tyrosol was detectable in most tissues except the brain, and the kidney tissues contained a significant amount of p-tyrosol compared to the other tissues after the i.g. administration of 100 mg/kg salidroside. The excretion behaviour revealed that the administrated salidroside mainly eliminated in the form of salidroside but not its aglycone metabolite p-tyrosol through urine. After i.v. and i.g. administration in rats, 64.00% and 23.80% of the total dose was excreted through urine in the form of salidroside, respectively. In addition, 0.19% and 2.25% of the dose was excreted in the form of p-tyrosol through urine after i.v. and i.g. administration, respectively. The faecal salidroside and p-tyrosol concentrations were 0.3% and 1.48% of the total dose after i.v. administration, respectively. After the i.g. administration of salidroside, trace salidroside and p-tyrosol were quantified in faeces within 72 h. In addition, the biliary excretion levels of salidroside after i.v. and i.g. administration were 2.86% and 0.02% of the dose, respectively. The obtained results show that salidroside was extensively metabolised to its aglycone p-tyrosol and distributed to various organs and the orginal salidroside was cleared rapidly through urine following the administration of salidroside.
C1 [Guo, Na; Yang, Qian] Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150006, Peoples R China.
   [Guo, Na; Zhu, Meixuan; Han, Xuejiao; Wang, Yang] Northeast Forestry Univ, Alkali Soil Nat Environm Sci Ctr, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Minist Educ, Harbin, Peoples R China.
   [Yang, Qian] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150006, Peoples R China.
   [Sui, Dan] Northeast Forestry Univ, Management Off Lab & Equipment, Ctr Anal & Testing, Harbin, Peoples R China.
C3 Harbin Institute of Technology; Northeast Forestry University - China;
   Harbin Institute of Technology; Northeast Forestry University - China
RP Yang, Q (corresponding author), Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150006, Peoples R China.
EM ywang@nefu.edu.cn; yangq@hit.edu.cn
RI yang, qian/HTS-5357-2023
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NR 32
TC 41
Z9 48
U1 0
U2 53
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 7
PY 2014
VL 9
IS 8
AR e103648
DI 10.1371/journal.pone.0103648
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AM6SB
UT WOS:000339993900021
PM 25101641
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gao, ZS
   Zhan, HH
   Zong, W
   Sun, MM
   Linghu, L
   Wang, GW
   Meng, FC
   Chen, M
AF Gao, Zhengshan
   Zhan, Honghong
   Zong, Wei
   Sun, Miaomiao
   Linghu, Lang
   Wang, Guowei
   Meng, Fancheng
   Chen, Min
TI Salidroside alleviates acetaminophen-induced hepatotoxicity via
   Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of
   NF-cB/NLRP3 inflammasome axis
SO LIFE SCIENCES
LA English
DT Article
DE Salidroside; Acetaminophen; Hepatotoxicity; Oxidative stress; Apoptosis;
   NLRP3 inflammasome
ID SIRTUIN 1; INJURY; MICE; STRESS; ROS
AB Acetaminophen (APAP) overdose-induced hepatotoxicity is the most common cause of drug-induced liver injury worldwide, which is significantly linked to oxidative stress and sterile inflammation. Salidroside is the main active component extracted from Rhodiola rosea L., with anti-oxidative and anti-inflammatory activities. Herein, we investigated the protective effects of salidroside on APAP-induced liver injury and its underlying mechanisms. Pretreatment with salidroside reversed the impacts of APAP on cell viability, LDH release, and cell apoptosis in L02 cells. Moreover, the phenomena of ROS accumulation and MMP collapse caused by APAP were reverted by salidroside. Salidroside elevated the levels of nuclear Nrf2, HO-1, and NQO1. Using PI3k/Akt inhibitor LY294002 further confirmed that salidroside mediated the Nrf2 nuclear translocation through the Akt pathway. Pretreatment with Nrf2 siRNA or LY294002 markedly prevented the anti-apoptotic effect of salidroside. Additionally, salidroside reduced the levels of nuclear NF-cB, NLRP3, ASC, cleaved caspase-1, and mature IL-10 elevated by APAP. Moreover, salidroside pretreatment increased Sirt1 expression, whereas Sirt1 knock-down diminished the protective activities of salidroside, simultaneously reversing the up-regulation of the Akt/Nrf2 pathway and the down-regulation of NF-cB/NLRP3 inflammasome axis mediated by salidroside. We then used C57BL/6 mice to establish APAP-induced liver injury models and found that salidroside significantly alleviated liver injury. Furthermore, western blot analyses showed that salidroside promoted the Sirt1 expression, activated the Akt/ Nrf2 pathway, and inhibited the NF-cB/NLRP3 inflammasome axis in APAP-treated mice. The findings of this study support a possible application of salidroside in the amelioration of APAP-induced hepatotoxicity.
C1 [Chen, Min] Southwest Univ, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing, Peoples R China.
   Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China.
C3 Southwest University - China; Southwest University - China
RP Chen, M (corresponding author), Southwest Univ, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing, Peoples R China.
EM mminchen@swu.edu.cn
RI Meng, FanCheng/IAO-5364-2023
OI Meng, FanCheng/0000-0003-0330-2023
FU National Natural Science Foundation of China [82074119]; Sub-project of
   Joint Funds of National Natural Science Foundation of China [U20A20401]
FX This work was supported by National Natural Science Foundation of China
   (grant number 82074119) and the Sub-project of Joint Funds of National
   Natural Science Foundation of China (grant number U20A20401) .
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NR 57
TC 31
Z9 37
U1 1
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 15
PY 2023
VL 327
AR 121793
DI 10.1016/j.lfs.2023.121793
EA JUN 2023
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA K2IQ1
UT WOS:001014732000001
PM 37224954
DA 2026-05-27
ER

PT J
AU Zhang, J
   Zhou, J
   He, ZY
   Xia, ZY
   Liu, HL
   Wu, Y
   Chen, S
   Wu, BM
   Li, HS
AF Zhang, Jun
   Zhou, Jing
   He, Zheyun
   Xia, Zhanyang
   Liu, Hongliang
   Wu, Yuan
   Chen, Si
   Wu, Boming
   Li, Hongshan
TI Salidroside attenuates NASH through regulating bile acid-FXR/TGR5
   signaling pathway via targeting gut microbiota
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Salidroside; Nonalcoholic steatohepatitis; Gut microbiota
ID NONALCOHOLIC STEATOHEPATITIS; INTESTINAL MICROBIOTA; RECEPTOR;
   METABOLISM
AB Nonalcoholic steatohepatitis (NASH) is a significant threat to human health. Our previous study revealed that salidroside attenuated NASH and regulated the gut microbiota. However, whether the therapeutic effect of salidroside depends on gut microbiota remains to be determined. Therefore, we conducted further experiments to elucidate the essential functions of gut microbiota-associated metabolic pathways in the anti-NASH effects of salidroside. Our results showed that salidroside effectively alleviated lipid accumulation and inflammatory injury in NASH mice. 16S rRNA sequencing revealed that salidroside increased the abundance of Bacteroides. Mice receiving fecal microbiota transplantation (FMT) from salidroside-treated also presented less hepatic steatosis and higher abundance of Bacteroides. Antibiotics eliminated the effects of salidroside on hepatic steatosis and the gut microbiota. Mechanistically, salidroside and FMT from salidroside-treated altered the bile acid (BA) profile by decreasing the levels of conjugated BAs and tauro-alpha/beta-muricholic acid and activated downstream farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). Furthermore, we found that inhibitors of bile salt hydrolase (BSH) and FXR/TGR5 abolished the effects of salidroside and reduced downstream carnitine palmitoyltransferase 1 alpha and lipoprotein lipase expression. These data demonstrate that salidroside attenuated NASH via gut microbiota-BA-FXR/TGR5 signaling pathway and reveal the underlying mechanism of salidroside on NASH.
C1 [Zhang, Jun; Zhou, Jing; Xia, Zhanyang; Liu, Hongliang; Wu, Yuan; Chen, Si; Wu, Boming; Li, Hongshan] Ningbo 2 Hosp, Liver Dis Dept Integrat Med, 41 XiBei St, Ningbo 315010, Zhejiang, Peoples R China.
   [Zhang, Jun] Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315300, Zhejiang, Peoples R China.
   [He, Zheyun] Ningbo 2 Hosp, Liver Dis Inst, Ningbo 315000, Zhejiang, Peoples R China.
   [Li, Hongshan] Ningbo 2 Hosp, Med Expt Dept, Ningbo 315000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Li, HS (corresponding author), Ningbo 2 Hosp, Liver Dis Dept Integrat Med, 41 XiBei St, Ningbo 315010, Zhejiang, Peoples R China.
EM lihongshan_1982@126.com
FU Zhejiang Provincial Natural Science Foundation of China [LY23H290004];
   Ningbo Natural Science Foundation [2021J317, 2022J242]; Major Special
   Science and Technology Project of Ningbo City [2022Z128]; National
   Administration of Traditional Chinese Medicine-Zhejiang Provincial
   Administration of Traditional Chinese Medicine Joint Construction
   Technology Plan [GZY-ZJ-KJ-23092]; Zhejiang Province Traditional Chinese
   Medicine Science and Technology Plan [2022ZB332]; Project of Ningbo
   Leading Medical & Health Discipline [2022Z01]; Medical Scientific
   Research Foundation of Zhejiang Province [2022KY1123]; Ningbo Medical
   Science and Technology Plan Project [2021Y11]
FX This work was supported by the Zhejiang Provincial Natural Science
   Foundation of China under Grant (LY23H290004) , Ningbo Natural Science
   Foundation (2022J242) , Major Special Science and Technology Project of
   Ningbo City (2022Z128) , National Administration of Traditional Chinese
   Medicine-Zhejiang Provincial Administration of Traditional Chinese
   Medicine Joint Construction Technology Plan (GZY-ZJ-KJ-23092) , Zhejiang
   Province Traditional Chinese Medicine Science and Technology Plan
   (2022ZB332) , Project of Ningbo Leading Medical & Health Discipline
   (2022Z01) , Ningbo Natural Science Foundation (2021J317) , Medical
   Scientific Research Foundation of Zhejiang Province (2022KY1123) ,
   Ningbo Medical Science and Technology Plan Project (2021Y11) .
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NR 47
TC 17
Z9 17
U1 14
U2 33
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD MAY
PY 2025
VL 307
AR 142276
DI 10.1016/j.ijbiomac.2025.142276
EA MAR 2025
PN 4
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 0TX1H
UT WOS:001455916800001
PM 40118401
DA 2026-05-27
ER

PT J
AU Qin, YL
   Zhang, RR
   Liu, WH
   Xu, XH
   Chen, FX
AF Qin, Yanlei
   Zhang, Rongrong
   Liu, Weihong
   Xu, Xunhua
   Chen, Fangxing
TI Salidroside Prevents Keloid Fibroblast Aggressive Progression by
   Upregulating miR-26a-5p to Inhibit JAG1
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Salidroside; JAG1; miR-26a-5p; Keloid; Fibroblast
ID NF-KAPPA-B; LUNG-CANCER; PROLIFERATION; PATHOGENESIS; ACTIVATION;
   EXPRESSION; INVASION; JAGGED1; CELLS
AB Salidroside, a natural herb, exerts considerable anti-tumor effects in various human cancers. Evidence unveils that Salidroside mediates gene expression to affect cancer progression. Our work intended to uncover the molecular mechanism of Salidroside functional role in keloid. Expression analysis for JAG1 and miR-26a-5p in tissues and cells was performed using qRT-PCR or western blotting. For functional analysis, cell proliferation, apoptosis and migration were ascertained by CCK-8, flow cytometry and Transwell assay, respectively. The putative binding relationship between JAG1 and miR-26a-5p was further confirmed by dual-luciferase reporter assay. Salidroside exerted pharmacological properties in keloid and impaired keloid fibroblast (KF) viability. JAG1 was upregulated in keloid tissues, and its expression was repressed by Salidroside in KFs. Salidroside depleted KF proliferation and migration but stimulated apoptosis, and JAG1 knockdown largely strengthened the functional effects of Salidroside. MiR-26a-5p interacted with JAG1 3 ' UTR and expressed with an opposite pattern with JAG1 in keloid. Inhibition of miR-26a-5p largely abolished the effects of JAG1 knockdown in Salidroside-treated KFs, leading to the recovery of KF aggressive behaviors. Salidroside blocked KF aggressive progression by upregulating miR-26a-5p to inhibit JAG1, which provided evidence on the anti-tumor effects of Salidroside in human keloid.
C1 [Qin, Yanlei; Zhang, Rongrong; Liu, Weihong; Xu, Xunhua; Chen, Fangxing] CR&Wisco Gen Hosp, Dept Radiol, Wuhan 430000, Hubei, Peoples R China.
RP Chen, FX (corresponding author), CR&Wisco Gen Hosp, Dept Radiol, Wuhan 430000, Hubei, Peoples R China.
EM chenfangxing@crmedical.hk
RI Weihong, Liu/GZL-4703-2022; Zhang, Rongrong/LZH-9205-2025
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NR 36
TC 3
Z9 3
U1 2
U2 4
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD JUN
PY 2025
VL 83
IS 2
BP 2577
EP 2587
DI 10.1007/s12013-025-01667-9
EA JAN 2025
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 2TU9F
UT WOS:001397877500001
PM 39825059
DA 2026-05-27
ER

PT J
AU Liu, XM
   Zhou, MX
   Dai, ZZ
   Luo, SJ
   Shi, YY
   He, ZJ
   Chen, YW
AF Liu, Xiaoman
   Zhou, Mingxia
   Dai, Zhenzhen
   Luo, Shangjian
   Shi, Yingying
   He, Zhenjuan
   Chen, Yingwei
TI Salidroside alleviates ulcerative colitis via inhibiting macrophage
   pyroptosis and repairing the dysbacteriosis-associated Th17/Treg
   imbalance
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE gut microbiota; IBD; pyroptosis; Salidroside; TREM1 signalling
ID INFLAMMATION; METABOLITES; PLASTICITY; CELLS
AB Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by flora disequilibrium and mucosal immunity disorder. Here, we report that salidroside effectively restricts experimental colitis from two aspects of intestinal macrophage pyroptosis and dysbacteriosis-derived colonic Th17/Treg imbalance. In innate immunity, the upregulated TREM1 and pyroptosis-related proteins in inflamed colons were inhibited by salidroside administration and further experiments in vitro showed that salidroside suppressed LPS/ATP-induced bone marrow-derived macrophages (BMDMs) pyroptosis evident by the decline of LDH and IL-1 beta release as well as the protein level of NLRP3, caspase-1, and GSDMD p30. Moreover, the TREM1 inhibitor weakened the effect of salidroside on BMDMs pyroptosis, whereas salidroside still could downregulate TREM1 when NLRP3 was inhibited. In adaptive immunity, salidroside improved the gut microflora diversity and Th17/Treg ratio in DSS-induced mice, especially promoting the abundance of Firmicutes. Clearance of the gut flora blocked the benefit of salidroside on colonic inflammation and Th17/Treg adaptive immunity, but transplanting salidroside-treated foecal bacterium into flora-depleted wild mice reproduced the resistance of salidroside to gut inflammation. Taken together, our data demonstrated that salidroside protected experimental colitis via skewing macrophage pyroptosis and Th17/Treg balance, indicating its potential effect on UC and other immune disorders.
C1 [Liu, Xiaoman; Luo, Shangjian; Shi, Yingying; Chen, Yingwei] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gastroenterol, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
   [Liu, Xiaoman; Zhou, Mingxia; Luo, Shangjian; Shi, Yingying] Shanghai Key Lab Pediat Gastroenterol & Nutr, Shanghai, Peoples R China.
   [Dai, Zhenzhen] Shanghai Inst Pediat Res, Shanghai, Peoples R China.
   [He, Zhenjuan] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Neonatol, Sch Med, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Chen, YW (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gastroenterol, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
EM chenyingwei@xinhuamed.com.cn
RI Luo, Shangjian/IAN-6578-2023; Dai, Zhenzhen/JNT-2153-2023
FU National Natural Science Foundation of China [8197030824] Funding
   Source: Medline
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NR 46
TC 83
Z9 103
U1 7
U2 84
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2023
VL 37
IS 2
BP 367
EP 382
DI 10.1002/ptr.7636
EA NOV 2022
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9C4RH
UT WOS:000878606600001
PM 36331009
DA 2026-05-27
ER

PT J
AU Rong, L
   Li, ZD
   Leng, X
   Li, HY
   Ma, YP
   Chen, YK
   Song, FZ
AF Rong, Li
   Li, Zhaodong
   Leng, Xue
   Li, Haiyu
   Ma, Yongping
   Chen, Yaokai
   Song, Fangzhou
TI Salidroside induces apoptosis and protective autophagy in human gastric
   cancer AGS cells through the PI3K/Akt/mTOR pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Gastric cancer; Apoptosis; Autophagy; PI3K/AKT/mTOR
ID MTOR PATHWAY; CHINA
AB Salidroside, a natural active ingredient extracted from Rhodiola rosea, has been shown to exert antitumor activity against breast cancer Dong Young et al. [1], colon cancer Sun et al. [2] and bladder cancer Tian et al. [3]. However, the effect of salidroside on apoptosis and autophagy in gastric cancer remains unclear. In our research, we observed the biological effect of salidroside on human gastric cancer AGS cells. Our results demonstrated that salidroside inhibited the growth of AGS cells both in vivo and in vitro and exerted a proapoptotic effect on AGS cells as confirmed by flow cytometry, Hoechst staining and western blot analysis. Additionally, we found that salidroside decreased the phosphorylation of PI3K and Akt and that pretreatment with the PI3K/Akt agonist IGF-1 could weaken the proapoptotic effect of salidroside. Interestingly, the exposure of AGS cells to salidroside induced autophagy as indicated by transmission electron microscopy, mRFP-GFP-LC3 transfection and western blot analysis, suggesting that salidroside promoted autophagy in gastric cancer AGS cells. Furthermore, treatment with the autophagy inhibitor chloroquine enhanced salidroside-induced cell apoptosis, indicating that the autophagy mediated by salidroside may protect AGS cells from death. Additionally, we found that salidroside decreased the level of p-mTOR protein in a concentration-dependent manner and that pretreatment with IGF-1 decreased the expression of autophagy proteins, suggesting that salidroside induced autophagy through the PI3K/Akt/mTOR pathway. The above findings indicate that salidroside inhibited the growth of gastric cancer and induced apoptosis and protective autophagy through the PI3K/Akt/mTOR pathway. In summary, our study provides novel insights regarding the activity of salidroside against gastric cancer and contributes to the clinical application of salidroside combined with autophagy inhibitors as a chemotherapeutic strategy for human gastric cancer.
C1 [Rong, Li; Li, Zhaodong; Leng, Xue; Li, Haiyu; Ma, Yongping; Song, Fangzhou] Chongqing Med Univ, Basic Med Coll, 1 Med Coll Rd, Chongqing 400016, Peoples R China.
   [Rong, Li; Li, Haiyu; Chen, Yaokai] Chongqing Publ Hlth Med Ctr, 109 Baoyu Rd, Chongqing 400036, Peoples R China.
C3 Chongqing Medical University
RP Song, FZ (corresponding author), Chongqing Med Univ, Basic Med Coll, 1 Med Coll Rd, Chongqing 400016, Peoples R China.; Chen, YK (corresponding author), Chongqing Publ Hlth Med Ctr, 109 Baoyu Rd, Chongqing 400036, Peoples R China.
EM l3883886491@163.com; 19702119@qq.com; 904561548@qq.com;
   lihaiyu@stu.cqmu.edu.cn; 93404551@qq.com; yaokaichen@hotmail.com;
   fzsongcq@163.com
OI Song, Fang/0000-0002-4083-3889
FU TCM Science and Technology Project of Chongqing Health and Family
   Planning Commission [ZY201702048]; Chongqing natural science foundation
   [cstc2019jcyj-msxmX0428]; National Science and Technology Major Project
   of China [2018ZX10302104]
FX 1. TCM Science and Technology Project of Chongqing Health and Family
   Planning Commission, Project number: ZY201702048. 2. Chongqing natural
   science foundation, Project number:cstc2019jcyj-msxmX0428 3. The
   National Science and Technology Major Project of China during the 13th
   five-year plan period. Project number: 2018ZX10302104.
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NR 31
TC 233
Z9 276
U1 8
U2 120
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2020
VL 122
AR 109726
DI 10.1016/j.biopha.2019.109726
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KA7VF
UT WOS:000506005800044
PM 31918283
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lai, WF
   Zheng, ZW
   Zhang, XQ
   Wei, YC
   Chu, KD
   Brown, J
   Hong, GZ
   Chen, LD
AF Lai, Wenfang
   Zheng, Zhenwei
   Zhang, Xiaoqin
   Wei, Yicong
   Chu, Kedan
   Brown, John
   Hong, Guizhu
   Chen, Lidian
TI Salidroside-Mediated Neuroprotection is Associated with Induction of
   Early Growth Response Genes (Egrs) Across a Wide Therapeutic Window
SO NEUROTOXICITY RESEARCH
LA English
DT Article
DE Salidroside; Brain ischemia; Microarray analysis; PC12 cells
ID CEREBRAL-ARTERY OCCLUSION; PC12 CELLS; SYNAPTIC PLASTICITY; INDUCED
   APOPTOSIS; EXPRESSION; BRAIN; RAT; TRANSCRIPTION; MECHANISMS; ISCHEMIA
AB Salidroside exhibits anti-inflammatory, antioxidative, and anti-apoptotic properties. To identify whether salidroside might be a candidate for treating ischemic stroke, we investigated the effects of salidroside or vehicle, given daily for 6 days, after middle cerebral artery occlusion (MCAO) for 2 h and reperfusion for either 1 or 48 h in rats. Salidroside reduced cerebral infarct volume and significantly improved neurological scores whether started after 1 or 48 h of reperfusion. Microarray analysis showed that 20 % (133/678) of the genes down-regulated by ischemia and 1 h of reperfusion were up-regulated by salidroside, whereas 13 % (105/829) of the genes induced by ischemia-reperfusion were inhibited by salidroside, suggesting that salidroside can reverse effects of ischemia-reperfusion on gene expression. The main enriched functional categories induced by salidroside were genes related to synaptic plasticity, whereas salidroside inhibited genes related to inflammation. Induction of Egr1, Egr2, Egr4, and Arc by salidroside was confirmed by qRT-PCR and western blotting in ischemic brains treated after either 1 or 48 h of reperfusion. The potential protective role of Egr4 in salidroside-mediated neuroprotection was subsequently investigated in CoCl2-treated PC12 cells. Egr4 was dose-dependently induced by salidroside in PC12 cells, and depleting Egr4 with target-specific siRNA increased caspase-3 activity and Bax, but decreased Bcl-xl, which were reversed by salidroside. Finally, we confirmed that salidroside inhibited the Bax/Bcl-xl-related apoptosis after MCAO with reperfusion. In conclusion, salidroside is highly neuroprotective with a wide therapeutic time window after ischemia-reperfusion injury in the rat, and this partially involves induction of Egrs, leading to inhibition of Bax/Bcl-xl-related apoptosis.
C1 [Lai, Wenfang; Zheng, Zhenwei; Zhang, Xiaoqin; Wei, Yicong; Chu, Kedan; Brown, John; Hong, Guizhu; Chen, Lidian] Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Peoples R China.
EM cbr@fjtcm.edu.cn
RI Chen, Lidian/GSN-6461-2022
OI Chen, Lidian/0000-0002-8699-0839
FU National Natural Science Foundation of China [81473382]; Department of
   Science & Technology of Fujian Province [2014Y4004]; Collaborative
   Innovation Center for Rehabilitation Technology of Fujian University of
   TCM; TCM Rehabilitation Research Center of SATCM
FX This work was supported by the National Natural Science Foundation of
   China (No. 81473382), the Department of Science & Technology of Fujian
   Province (No. 2014Y4004), the Collaborative Innovation Center for
   Rehabilitation Technology of Fujian University of TCM and the TCM
   Rehabilitation Research Center of SATCM. The authors would like to thank
   Mr. Bin Chen for his support in the animal surgery.
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NR 47
TC 40
Z9 56
U1 0
U2 36
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1029-8428
EI 1476-3524
J9 NEUROTOX RES
JI Neurotox. Res.
PD AUG
PY 2015
VL 28
IS 2
BP 108
EP 121
DI 10.1007/s12640-015-9529-9
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CQ6BF
UT WOS:000360688700002
PM 25911293
DA 2026-05-27
ER

PT J
AU Zhu, L
   Liu, ZC
   Ren, YQ
   Wu, XL
   Liu, YJ
   Wang, TT
   Li, YZ
   Cong, YS
   Guo, YL
AF Zhu, Lin
   Liu, Zhenchao
   Ren, Yuqian
   Wu, Xiaolin
   Liu, Yingjuan
   Wang, Tingting
   Li, Yizhao
   Cong, Yusheng
   Guo, Yunliang
TI Neuroprotective effects of salidroside on ageing hippocampal neurons and
   naturally ageing mice via the PI3K/Akt/TERT pathway
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE hippocampal neuron; mice; salidroside; senescence; telomerase reverse
   transcriptase
ID TELOMERASE PROTEIN TERT; REVERSE-TRANSCRIPTASE; ALZHEIMERS-DISEASE;
   CATALYTIC SUBUNIT; IN-VITRO; BRAIN; EXPRESSION; ROS; MITOCHONDRIA;
   ACTIVATION
AB Studies have found that salidroside, isolated from Rhodiola rosea L, has various pharmacological activities, but there have been no studies on the effects of salidroside on brain hippocampal senescence. The purpose of this study was to investigate the mechanistic role of salidroside in hippocampal neuron senescence and injury. In this study, long-term cultured primary rat hippocampal neurons and naturally aged C57 mice were treated with salidroside. The results showed that salidroside increased the viability and MAP2 expression, reduced beta-galactosidase (beta-gal) levels of rat primary hippocampal neurons. Salidroside also improved cognition dysfunction in ageing mice and alleviated neuronal degeneration in the ageing mice CA1 region. Moreover, salidroside decreased the levels of oxidative stress and p21, p16 protein expressions of hippocampal neurons and ageing mice. Salidroside promoted telomerase reverse transcriptase (TERT) protein expression via the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway. In conclusion, our findings suggest that salidroside has the potential to be used as a therapeutic strategy for anti-ageing and ageing-related disease treatment.
C1 [Zhu, Lin; Liu, Zhenchao; Ren, Yuqian; Wu, Xiaolin; Liu, Yingjuan; Wang, Tingting; Guo, Yunliang] Qingdao Univ, Med Res Ctr, Taishan Scholars Construct Project Excellent Inno, Inst Cerebrovasc Dis,Affiliated Hosp, Qingdao 266003, Shangdong, Peoples R China.
   [Li, Yizhao] Jinan Fanggan Rehabil Hosp, Dept Neurol, Jinan, Peoples R China.
   [Cong, Yusheng] Hangzhou Normal Univ, Inst Aging Res, Sch Med, Hangzhou, Peoples R China.
C3 Qingdao University; Hangzhou Normal University
RP Guo, YL (corresponding author), Qingdao Univ, Med Res Ctr, Taishan Scholars Construct Project Excellent Inno, Inst Cerebrovasc Dis,Affiliated Hosp, Qingdao 266003, Shangdong, Peoples R China.
EM guoqdsd@163.com
FU National Natural Science Fund of China [81973501]; Provincial Natural
   Science Fund of Shandong [ZR2019MH009]; Qingdao Municipal Fund of
   Science and Technology [18-6-1-84-nsh]
FX This experiment was supported by grant-in-aids from the National Natural
   Science Fund of China (81973501), Provincial Natural Science Fund of
   Shandong (ZR2019MH009), and Qingdao Municipal Fund of Science and
   Technology (18-6-1-84-nsh).
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NR 49
TC 31
Z9 33
U1 2
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2021
VL 35
IS 10
BP 5767
EP 5780
DI 10.1002/ptr.7235
EA AUG 2021
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WL6EZ
UT WOS:000683169400001
PM 34374127
DA 2026-05-27
ER

PT J
AU Xue, HY
   Li, PP
   Luo, YS
   Wu, CW
   Liu, Y
   Qin, XG
   Huang, XZ
   Sun, C
AF Xue, Haiyan
   Li, Peipei
   Luo, Yishu
   Wu, Chuwen
   Liu, Yue
   Qin, Xiaogang
   Huang, Xinzhong
   Sun, Cheng
TI Salidroside stimulates the Sirt1/PGC-1α axis and ameliorates diabetic
   nephropathy in mice
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; Diabetic nephropathy; Sirt1; PGC-1 alpha; Mitochondrial
   biogenesis
ID GLUCOSE-HOMEOSTASIS; SIGNALING PATHWAY; OXIDATIVE STRESS; RODENT MODELS;
   MITOCHONDRIA; PGC-1-ALPHA; SENSITIVITY; ACTIVATION; PROTECTS; TISSUES
AB Background: Salidroside, an active component from Traditional Chinese Medicine Rhodiola rosea L., has various pharmacological functions including anti-inflammatory, anti-cancer and anti-oxidative properties. However, whether salidroside plays a beneficial role in diabetic nephropathy is still unclear.
   Purpose: The objective of this work was to investigate the potential roles of salidroside against diabetic nephropathy and the underlying molecular mechanisms.
   Methods: Streptozocin was given to obese mice to generate diabetic nephropathy animal model. Salidroside was administered to these mice and proteinuria, podocyte integrity, renal morphology and fibrosis, mitochondrial biogenesis were examined.
   Results: Our results showed that salidroside treatment greatly attenuates diabetic nephropathy as evidenced by decreased urinary albumin, blood urea nitrogen and serum creatinine. Morphological analysis indicated that salidroside improves renal structures in diabetic nephropathy. The decreases in nephrin and podocin expression were markedly reversed by salidroside. Moreover, kidney fibrosis in diabetic nephropathy mice was largely prevented by salidroside. Mechanistically, in salidroside-treated mice, the mitochondrial DNA copy and electron transport chain proteins were significantly enhanced. Meanwhile, the reduced Sirt1 and PGC-1 alpha expression in diabetic nephropathy was almost completely counteracted in the presence of salidroside.
   Conclusions: Our data showed that salidroside plays a beneficial role against diabetic nephropathy in mice, which probably via Sirt1/PGC-1 alpha mediated mitochondrial biogenesis.
C1 [Xue, Haiyan; Li, Peipei; Wu, Chuwen; Huang, Xinzhong] Nantong Univ, Dept Nephrol, Affiliated Hosp, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Luo, Yishu] Nantong Univ, Sch Med, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Liu, Yue; Qin, Xiaogang] Tradit Chinese Med Hosp Tongzhou Dist, Dept Nephrol, 8 Jianshe Rd, Nantong 226300, Jiangsu, Peoples R China.
   [Sun, Cheng] Nantong Univ, Key Lab Neuroregenerat Jiangsu Prov, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Sun, Cheng] Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University
RP Huang, XZ (corresponding author), Nantong Univ, Dept Nephrol, Affiliated Hosp, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China.; Sun, C (corresponding author), Nantong Univ, Key Lab Neuroregenerat Jiangsu Prov, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.; Sun, C (corresponding author), Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM huangxz421@126.com; suncheng1975@ntu.edu.cn
RI peipei, li/GWC-0553-2022; Sun, Cheng/M-8729-2017
OI Sun, Cheng/0000-0001-8411-4619
FU National Key Research and Development Program of China [2017YFA0701304];
   National Natural Science Foundation of China [81471037, 81770841];
   Project of "Six Kinds of Talents Summit" of Jiangsu Province [SWYY-051];
   Health and Family Planning Commission research projects of Jiangsu
   [H201522]; Science and Technology Foundation of Nantong [BK2013006]; Dr.
   Scientific Research Foundation of Nantong University, Jiangsu Province,
   China [14B40]
FX This research was supported by the National Key Research and Development
   Program of China(Grant no. 2017YFA0701304); the National Natural Science
   Foundation of China (Grant nos: 81471037; 81770841); the Project of "Six
   Kinds of Talents Summit" of Jiangsu Province (SWYY-051); the Health and
   Family Planning Commission research projects of Jiangsu (Grant no.
   H201522), the Science and Technology Foundation of Nantong (BK2013006)
   and the Dr. Scientific Research Foundation of Nantong University,
   Jiangsu Province, China (Grant no. 14B40).
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TC 173
Z9 201
U1 10
U2 132
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
J9 PHYTOMEDICINE
JI Phytomedicine
PD FEB 15
PY 2019
VL 54
BP 240
EP 247
DI 10.1016/j.phymed.2018.10.031
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA HN3XW
UT WOS:000460119500024
PM 30668374
DA 2026-05-27
ER

PT J
AU Wang, MH
   Luo, L
   Yao, LL
   Wang, CP
   Jiang, KT
   Liu, XY
   Xu, MC
   Shen, NM
   Guo, SD
   Sun, C
   Yang, YM
AF Wang, Meihong
   Luo, Lan
   Yao, Lili
   Wang, Caiping
   Jiang, Ketao
   Liu, Xiaoyu
   Xu, Muchen
   Shen, Ningmei
   Guo, Shaodong
   Sun, Cheng
   Yang, Yumin
TI Salidroside improves glucose homeostasis in obese mice by repressing
   inflammation in white adipose tissues and improving leptin sensitivity
   in hypothalamus
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; HEPATIC
   GLUCONEOGENESIS; HIPPOCAMPAL-NEURONS; LINKS OBESITY; ADIPOGENESIS;
   MACROPHAGES; ACTIVATION; MECHANISMS; AMPK
AB Salidroside is a functionally versatile natural compound from the perennial flowering plant Rhodiola rosea L. Here, we examined obese mice treated with salidroside at the dosage of 50 mg/kg/day for 48 days. Mice treated with salidroside showed slightly decreased food intake, body weight and hepatic triglyceride content. Importantly, salidroside treatment significantly improved glucose and insulin tolerance. It also increased insulin singling in both liver and epididymal white adipose tissue (eWAT). In addition, salidroside markedly ameliorated hyperglycemia in treated mice, which is likely due to the suppression of gluconeogenesis by salidroside as the protein levels of a gluconeogenic enzyme G6Pase and a co-activator PGC-1 alpha were all markedly decreased. Further analysis revealed that adipogenesis in eWAT was significantly decreased in salidroside treated mice. The infiltration of macrophages in eWAT and the productions of pro-inflammatory cytokines were also markedly suppressed by salidroside. Furthermore, the leptin signal transduction in hypothalamus was improved by salidroside. Taken together, these euglycemic effects of salidroside may due to repression of adipogenesis and inflammation in eWAT and stimulation of leptin signal transduction in hypothalamus. Thus, salidroside might be used as an effective anti-diabetic agent.
C1 Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Wang, Meihong; Wang, Caiping; Jiang, Ketao; Liu, Xiaoyu; Sun, Cheng; Yang, Yumin] Affiliated Hosp Nantong Univ, Dept Geratol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Luo, Lan] Affiliated Hosp Nantong Univ, Dept Endocrinol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Xu, Muchen; Shen, Ningmei] Nantong Univ, Sch Med, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Guo, Shaodong] Texas A&M Univ Hlth Sci Ctr, Coll Med, Dept Med, Div Mol Cardiol, Round Rock, TX USA.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University; Texas A&M University System; Texas A&M University College
   Station; Texas A&M Health Science Center
RP Sun, C; Yang, YM (corresponding author), Affiliated Hosp Nantong Univ, Dept Geratol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM suncheng1975@ntu.edu.cn; yangym@ntu.edu.cn
RI Guo, Shaodong/W-5552-2019; Sun, Cheng/M-8729-2017
OI Xu, Muchen/0000-0002-8768-1050
FU National Natural Science Foundation of China [31271260, 81471037]; Basic
   Research of Jiangsu Education Department [14KJA180006]; Project of "Six
   Kinds of Talents Summit" of Jiangsu Province [2013-WSN-071];
   Postgraduate Creative Program of Nantong University [YKC14067]; Priority
   Academic Program Development (PAPD) of Jiangsu Higher Education
   Institutions
FX We thank Drs Ji Miao and Weihong Qiu for their critical reading of our
   manuscript. This work was supported by grants from the National Natural
   Science Foundation of China (31271260, 81471037), the Basic Research of
   Jiangsu Education Department (14KJA180006), the Project of "Six Kinds of
   Talents Summit" of Jiangsu Province (2013-WSN-071), the Postgraduate
   Creative Program of Nantong University (YKC14067) and the Priority
   Academic Program Development (PAPD) of Jiangsu Higher Education
   Institutions.
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Z9 55
U1 2
U2 33
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 5
PY 2016
VL 6
AR 25399
DI 10.1038/srep25399
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DL2QI
UT WOS:000375479600001
PM 27145908
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jiang, JJ
   Yin, H
   Wang, SA
   Zhuang, YB
   Liu, SW
   Liu, T
   Ma, YH
AF Jiang, Jingjie
   Yin, Hua
   Wang, Shuai
   Zhuang, Yibin
   Liu, Shaowei
   Liu, Tao
   Ma, Yanhe
TI Metabolic Engineering of Saccharomyces cerevisiae for High-Level
   Production of Salidroside from Glucose
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Saccharomyces cerevisiae; salidroside; tyrosol; glucosyltransferase
ID AMINO-ACID BIOSYNTHESIS; RHODIOLA-SACHALINENSIS; ESCHERICHIA-COLI;
   PATHWAY; CRENULATA; SYNTHASE; TYROSINE; EHRLICH; ENZYME; CELLS
AB Salidroside is an important plant-derived aromatic compound with diverse biological properties. Because of inadequate natural resources, the supply of salidroside is currently limited. In this work, we engineered the production of salidroside in yeast. First, the aromatic aldehyde synthase (AAS) from Petroselinum crispum was overexpressed in Saccharomyces cerevisiae when combined with endogenous Ehrlich pathway to produce tyrosol from tyrosine. Glucosyltransferases from different resources were tested for ideal production of salidroside in the yeast. Metabolic flux was enhanced toward tyrosine biosynthesis by overexpressing pathway genes and eliminating feedback inhibition. The pathway genes were integrated into yeast chromosome, leading to a recombinant strain that produced 239.5 mg/L salidroside and 965.4 mg/L tyrosol. The production of salidroside and tyrosol reached up to 732.5 and 1394.6 mg/L, respectively, by fed-batch fermentation. Our work provides an alternative way for industrial large-scale production of salidroside and tyrosol from S. cerevisiae.
C1 [Jiang, Jingjie; Liu, Shaowei] East China Univ Sci & Technol, Coll Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
   [Yin, Hua; Wang, Shuai; Zhuang, Yibin; Liu, Tao; Ma, Yanhe] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.
   [Yin, Hua; Zhuang, Yibin; Liu, Tao; Ma, Yanhe] Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
   [Wang, Shuai] Tianjin Univ Sci & Technol, Coll Biotechnol, Natl & Local United Engn Lab Metab Control Fermen, Tianjin 300457, Peoples R China.
C3 East China University of Science & Technology; Chinese Academy of
   Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Chinese
   Academy of Sciences; Tianjin University of Science & Technology
RP Liu, SW (corresponding author), East China Univ Sci & Technol, Coll Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.; Liu, T (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.; Liu, T (corresponding author), Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
EM swliu@ecust.edu.cn; liu_t@tib.cas.cn
RI Wang, Shuai/HZJ-7466-2023
FU National Natural Science Foundation of China [31770104, 21302214,
   31400026]; Biological Resources Service Plan of CAS [ZSTH-023]
FX This work was supported by grants from the National Natural Science
   Foundation of China (nos. 31770104, 21302214, and 31400026) and the
   Biological Resources Service Plan of CAS (no. ZSTH-023).
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NR 30
TC 62
Z9 81
U1 5
U2 232
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 2
PY 2018
VL 66
IS 17
BP 4431
EP 4438
DI 10.1021/acs.jafc.8b01272
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GF0DN
UT WOS:000431600200016
PM 29671328
DA 2026-05-27
ER

PT J
AU Tao, L
   Liang, ZF
   Miao, L
   Guo, YJ
   Li, Y
   Liu, YL
   Fang, DM
   Yang, ZJ
AF Tao, Lin
   Liang, Zhi-Fang
   Miao, Liu
   Guo, Yu-Jie
   Li, Ye
   Liu, Yan-Li
   Fang, Dong-Ming
   Yang, Zhi-Jie
TI Mechanism of salidroside against coronary artery disease by network
   pharmacology analysis
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Gene expression omnibus; Salidroside; Coronary artery disease; Network
   pharmacological
ID ENDOTHELIAL GROWTH-FACTOR; GENE-THERAPY; ANGIOGENESIS; ISCHEMIA; CELLS
AB BackgroundRosenroot (Rhodiola rosea) is a traditional Chinese herbal medicine. It has been used to treat patients with coronary artery disease (CAD). Salidroside is the main active constituent of rosenroot. This study was designed to explore the mechanism of salidroside in treating CAD and its role in angiogenesis in CAD systematically.MethodsIn this study, potential targets related to salidroside and CAD were obtained from public databases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Disease Ontology (DO) and CellMarker enrichment analyses were performed. The binding of salidroside to angiogenesis-related targets was assessed by PyMOL and Ligplot. Furthermore, the effects of salidroside on collateral circulation were evaluated by correlation analysis of these angiogenesis-related targets with the coronary flow index (CFI), and the influence of salidroside on human umbilical vein endothelial cell (HUVEC) proliferation and migration was assessed.ResultsEighty-three targets intersected between targets of salidroside and CAD. GO and KEGG analyses indicated that salidroside mainly treated CAD through angiogenesis and anti-inflammatory action. There were 12 angiogenesis-related targets of salidroside in coronary heart disease, among which FGF1 (r = 0.237, P = 2.597E-3), KDR (r = 0.172, P = 3.007E-2) and HIF1A (r = -0.211, P = 7.437E-3) were correlated with the coronary flow index (CFI), and salidroside docked well with them. Finally, cell experiments confirmed that salidroside promoted the proliferation and migration of HUVECs.ConclusionsThis study revealed the potential molecular mechanism of salidroside on angiogenesis in CAD and provided new ideas for the clinical application of salidroside in the treatment of CAD.
C1 [Tao, Lin; Liang, Zhi-Fang; Miao, Liu; Guo, Yu-Jie; Li, Ye; Liu, Yan-Li; Fang, Dong-Ming; Yang, Zhi-Jie] Liuzhou Peoples Hosp, Dept Cardiol, 8 Wenchang Rd, Liuzhou 545006, Guangxi, Peoples R China.
RP Yang, ZJ (corresponding author), Liuzhou Peoples Hosp, Dept Cardiol, 8 Wenchang Rd, Liuzhou 545006, Guangxi, Peoples R China.
EM yfyyzj@163.com
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NR 42
TC 7
Z9 7
U1 1
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD JUN 12
PY 2023
VL 23
IS 1
AR 194
DI 10.1186/s12906-023-04027-3
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA I6CF7
UT WOS:001003636600001
PM 37308900
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guan, S
   Feng, HH
   Song, BC
   Guo, WX
   Xiong, Y
   Huang, GR
   Zhong, WT
   Huo, MX
   Chen, N
   Lu, J
   Deng, XM
AF Guan, Shuang
   Feng, Haihua
   Song, Bocui
   Guo, Weixiao
   Xiong, Ying
   Huang, Guoren
   Zhong, Weiting
   Huo, Meixia
   Chen, Na
   Lu, Jing
   Deng, Xuming
TI Salidroside attenuates LPS-induced pro-inflammatory cytokine responses
   and improves survival in murine endotoxemia
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Cytokines; Endotoxemia; NF- B; ERK/MAPKs
ID RHODIOLA-ROSEA L.; IN-VITRO; STRESS; SHOCK
AB Salidroside is a major component isolated from the Rhodiola rosea. In the present study, we investigated the anti-inflammatory effects of salidroside on cytokine production by lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro, and the results showed that salidroside reduced tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) secretions. This inspired us to further study the effects of salidroside in vivo. Salidroside significantly attenuated TNF-alpha, IL-1 beta and IL-6 productions in serum from mice challenged with LPS, and consistent with the results in vitro. In the murine model of endotoxemia, mice were treated with salidroside prior to or after LPS challenge. The results showed that salidroside significantly increased mouse survival. Further studies revealed that salidroside could downregulate LPS-induced nuclear transcription factor- B (NF- B) DNA-binding activation and ERK/MAPKs signal transduction pathways production in RAW 264.7 macrophages. These observations indicated that salidroside modulated early cytokine responses by blocking NF- B and ERK/MAPKs activation, and thus, increased mouse survival. These effects of salidroside may be of potential usefulness in the treatment of inflammation-mediated endotoxemia. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Guan, Shuang; Feng, Haihua; Song, Bocui; Guo, Weixiao; Xiong, Ying; Zhong, Weiting; Huo, Meixia; Chen, Na; Lu, Jing; Deng, Xuming] Jilin Univ, Coll Anim Sci & Vet Med, Dept Vet Pharmacol, Changchun 130062, Jilin, Peoples R China.
   [Guan, Shuang; Huang, Guoren; Lu, Jing] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Lu, J (corresponding author), Jilin Univ, Coll Anim Sci & Vet Med, Dept Vet Pharmacol, Changchun 130062, Jilin, Peoples R China.
EM fhh70@163.com; xlujing1@yahoo.com.cn; xumingdeng@jluhp.edu.cn
RI Guan, Shuang/JXN-9245-2024; Xiong, Yingzhu/LOR-2049-2024
FU National Nature Science Foundation of China [30972212]
FX This study was financed by the National Nature Science Foundation of
   China (No. 30972212).
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NR 19
TC 74
Z9 86
U1 0
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC
PY 2011
VL 11
IS 12
BP 2194
EP 2199
DI 10.1016/j.intimp.2011.09.018
PG 6
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 867NI
UT WOS:000298460700033
PM 22019446
DA 2026-05-27
ER

PT J
AU Wei, GY
   Xu, XQ
   Tong, H
   Wang, XM
   Chen, YT
   Ding, YY
   Zhang, SX
   Ju, W
   Fu, CL
   Li, ZY
   Zeng, LY
   Xu, KL
   Qiao, JL
AF Wei, Guangyu
   Xu, Xiaoqi
   Tong, Huan
   Wang, Xiamin
   Chen, Yuting
   Ding, Yangyang
   Zhang, Sixuan
   Ju, Wen
   Fu, Chunling
   Li, Zhenyu
   Zeng, Lingyu
   Xu, Kailin
   Qiao, Jianlin
TI Salidroside inhibits platelet function and thrombus formation through
   AKT/GSK3β signaling pathway
SO AGING-US
LA English
DT Article
DE salidroside; platelet; thrombus formation; AKT; GSK3 beta
ID GLYCOGEN-SYNTHASE KINASE-3; NEGATIVE REGULATOR; ACTIVATION; RECEPTORS;
   GSK3; AKT; GROWTH; INJURY; CELLS
AB Salidroside is the main bioactive component in Rhodiola rosea and possesses multiple biological and pharmacological properties. However, whether salidroside affects platelet function remains unclear. Our study aims to investigate salidroside's effect on platelet function. Human or mouse platelets were treated with salidroside (0-20 mu M) for 1 hour at 37 degrees C. Platelet aggregation, granule secretion, and receptors expression were measured together with detection of platelet spreading and clot retraction. In addition, salidroside (20 mg/kg) was intraperitoneally injected into mice followed by measuring tail bleeding time, arterial and venous thrombosis. Salidroside inhibited thrombin- or CRP-induced platelet aggregation and ATP release and did not affect the expression of P-selectin, glycoprotein (GP) Ib alpha, GPVI and alpha(IIb)beta(3). Salidroside-treated platelets presented decreased spreading on fibrinogen or collagen and reduced clot retraction with decreased phosphorylation of c-Src, Syk and PLC gamma 2. Additionally, salidroside significantly impaired hemostasis, arterial and venous thrombus formation in mice. Moreover, in thrombin-stimulated platelets, salidroside inhibited phosphorylation of AKT (T308/S473) and GSK3 beta (Ser9). Further, addition of GSK3 beta inhibitor reversed the inhibitory effect of salidroside on platelet aggregation and clot retraction. In conclusion, salidroside inhibits platelet function and thrombosis via AKT/GSK3 beta signaling, suggesting that salidroside may be a novel therapeutic drug for treating thrombotic or cardiovascular diseases.
C1 [Wei, Guangyu; Xu, Xiaoqi; Tong, Huan; Wang, Xiamin; Chen, Yuting; Ding, Yangyang; Zhang, Sixuan; Ju, Wen; Fu, Chunling; Li, Zhenyu; Zeng, Lingyu; Xu, Kailin; Qiao, Jianlin] Xuzhou Med Univ, Blood Dis Inst, Xuzhou, Jiangsu, Peoples R China.
   [Wei, Guangyu; Xu, Xiaoqi; Tong, Huan; Wang, Xiamin; Chen, Yuting; Ding, Yangyang; Zhang, Sixuan; Ju, Wen; Fu, Chunling; Li, Zhenyu; Zeng, Lingyu; Xu, Kailin; Qiao, Jianlin] Xuzhou Med Univ, Affiliated Hosp, Dept Hematol, Xuzhou, Jiangsu, Peoples R China.
   [Wei, Guangyu; Xu, Xiaoqi; Tong, Huan; Wang, Xiamin; Chen, Yuting; Ding, Yangyang; Zhang, Sixuan; Ju, Wen; Fu, Chunling; Li, Zhenyu; Zeng, Lingyu; Xu, Kailin; Qiao, Jianlin] Key Lab Bone Marrow Stem Cell, Xuzhou, Jiangsu, Peoples R China.
C3 Xuzhou Medical University; Xuzhou Medical University
RP Zeng, LY; Xu, KL; Qiao, JL (corresponding author), Xuzhou Med Univ, Blood Dis Inst, Xuzhou, Jiangsu, Peoples R China.; Zeng, LY; Xu, KL; Qiao, JL (corresponding author), Xuzhou Med Univ, Affiliated Hosp, Dept Hematol, Xuzhou, Jiangsu, Peoples R China.; Zeng, LY; Xu, KL; Qiao, JL (corresponding author), Key Lab Bone Marrow Stem Cell, Xuzhou, Jiangsu, Peoples R China.
EM zengly2000@163.com; lihmd@163.com; jianlin.qiao@gmail.com
RI Ding, Yangyang/LMQ-3038-2024; Qiao, Jianlin/ADV-0229-2022; Huan,
   Tong/ADZ-0566-2022
OI Huan, Tong/0000-0002-0264-872X
FU National Natural Science Foundation of China [81970124, 81400082,
   81641151, 81700178]; Natural Science Foundation of Jiangsu Province
   [BK20140219, BK20170259]; Distinguished Professorship Program of Jiangsu
   Province; Shuangchuang Project of Jiangsu Province; Six Talent Peaks
   Project of Jiangsu Province [WSN-133]; 333 projects of Jiangsu Province
   [BRA2017542]; Natural Science Foundation of the Jiangsu Higher Education
   Institutions of China [18KJA320010, 17KJA320008]; Jiangsu Province's Key
   Provincial Talents Program [ZDRCA2016054]; Jiangsu Province's Graduate
   Scientific Research Innovation Program [KYCX18-2186, KYCX19-2231,
   KYCX19-2234]; Youth Science and Technology Innovation Team of Xuzhou
   Medical University
FX This work was supported by National Natural Science Foundation of China
   (grant no. 81970124, 81400082, 81641151 and 81700178), the Natural
   Science Foundation of Jiangsu Province (grant no. BK20140219 and
   BK20170259), the funding for the Distinguished Professorship Program of
   Jiangsu Province, the Shuangchuang Project of Jiangsu Province, the Six
   Talent Peaks Project of Jiangsu Province (WSN-133), the 333 projects of
   Jiangsu Province (BRA2017542), the Natural Science Foundation of the
   Jiangsu Higher Education Institutions of China (18KJA320010 and
   17KJA320008), Jiangsu Province's Key Provincial Talents Program
   (ZDRCA2016054), Jiangsu Province's Graduate Scientific Research
   Innovation Program (KYCX18-2186, KYCX19-2231 and KYCX19-2234) and Youth
   Science and Technology Innovation Team of Xuzhou Medical University.
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NR 59
TC 31
Z9 33
U1 0
U2 43
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD MAY 15
PY 2020
VL 12
IS 9
BP 8151
EP 8166
DI 10.18632/aging.103131
PG 16
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA LN7ZB
UT WOS:000533150800035
PM 32352928
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Liu, SS
   Xia, YY
   Yang, HQ
   Shen, W
   Chen, XZ
AF Liu, Sisi
   Xia, Yuanyuan
   Yang, Haiquan
   Shen, Wei
   Chen, Xianzhong
TI Rational chromosome engineering of Escherichia coli for
   overproduction of salidroside
SO BIOCHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Salidroside; Escherichia coli; Chromosome engineering; Tyrosol; de novo
   synthesis
ID PYRUVATE OXIDASE; RHODIOLA-ROSEA; METABOLISM; PERFORMANCE; PCR
AB Salidroside is a naturally occurring phenylpropanoid glycoside which widely used in food and cosmetics. The development of microbial synthesis of salidroside is limited due to the low titer and the addition of inducers and antibiotics. Based on our previously constructed high tyrosol-producing recombinant Escherichia coli, we identified the catalytic activity of glycosyltransferase UGT85A1 was high. The strain carrying plasmid pKK223UGT85A1 produced 2.5 g/L of salidroside in shake flask. To construct a stable, non-inducible, antibiotic-free salidroside-producing strain, UGT85A1 gene was integrated into genomic sites and the single-copy strain could only produce about 120 mg/L of salidroside. Therefore, we designed a multi-copy integration strategy and obtained an eight-copy number recombinant strain 5A8S. The production of salidroside also increased sequentially and the strains grew well. When the strain 5A8S was cultured in a shake flask, the salidroside production reached 2.42 g/L. Then, we carried out a scale-up culture of strains 5A-UGT85A1 and 5A8S in a 5 L fermenter, and the salidroside titers were 9.48 and 9.34 g/L, respectively. In this study, a non-inducible high-yield salidroside recombinant strain was successfully constructed using a multi-copy integration strategy in the non-coding region of the genome, thus laying the foundation for efficient green biosynthesis of salidroside.
C1 [Chen, Xianzhong] Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China.
   Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Chen, XZ (corresponding author), Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China.
EM xzchen@jiangnan.edu.cn
OI Xia, Yuanyuan/0000-0002-1054-2044
FU Key Research and Development Pro-gram of China [2021YFC2100102-03];
   National Natural Science Foundation of China [32001064]
FX Acknowledgement This study was funded by the Key Research and
   Development Pro-gram of China (2021YFC2100102-03) , the National Natural
   Science Foundation of China (32001064) .
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NR 35
TC 13
Z9 17
U1 10
U2 123
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1369-703X
EI 1873-295X
J9 BIOCHEM ENG J
JI Biochem. Eng. J.
PD JUN
PY 2022
VL 184
AR 108474
DI 10.1016/j.bej.2022.108474
EA MAY 2022
PG 9
WC Biotechnology & Applied Microbiology; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 2G1RQ
UT WOS:000813375900003
DA 2026-05-27
ER

PT J
AU Wang, M
   Zhang, N
   Ji, RL
   Zhao, J
AF Wang, Ming
   Zhang, Ning
   Ji, Rili
   Zhao, Jing
TI Effect of salidroside on Bcl-2/Bax protein levels in rats with
   hemisection-induced spinal cord injury
SO AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE Salidroside; spinal cord injury (SCI); Bcl-2/Bax; apoptosis
ID CELL-CYCLE ARREST; METHYLPREDNISOLONE; APOPTOSIS
AB The effect of salidroside on Bcl-2/Bax protein levels in rats with hemisection-induced spinal cord injury (SCI) was studied. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham operation group, SCI model group, methylprednisolone sodium succinate (MPSS) treatment group, salidroside-low dosage treatment group, salidroside-moderate dosage treatment group, and salidroside-high dosage treatment group. The SD rats were hemisected at the spinal cord, at the T8 vertebra to establish SCI model. 24 h after operation, different dosage of salidroside increased and reduced the protein levels. Noticeably, salidroside at the 100 mg/kg dosage exhibited similar effects as MPSS, which has been frequently used for clinical acute SCI. These results suggested that salidroside can significantly inhibit apoptosis in acute SCI.
C1 [Zhao, Jing] Zhejiang Chinese Med Univ, Inst Pharmaceut, Hangzhou 310000, Zhejiang, Peoples R China.
   [Wang, Ming] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Urol, Hangzhou 310000, Zhejiang, Peoples R China.
   [Zhang, Ning] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou 310000, Zhejiang, Peoples R China.
   [Ji, Rili] Zhaohui Community Hlth Serv Ctr, TCM Pharm, Hangzhou 310000, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang University; Zhejiang
   University
RP Zhao, J (corresponding author), Zhejiang Chinese Med Univ, Inst Pharmaceut, Hangzhou 310000, Zhejiang, Peoples R China.
EM zhaoj31@126.com
RI Zhang, Ning/LEM-5455-2024
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NR 22
TC 0
Z9 0
U1 0
U2 7
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0816
J9 AFR J PHARM PHARMACO
JI Afr. J. Pharm. Pharmacol.
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PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 994XU
UT WOS:000307968900008
OA gold
DA 2026-05-27
ER

PT J
AU Zhu, Y
   Shi, YP
   Wu, D
   Ji, YJ
   Wang, X
   Chen, HL
   Wu, SS
   Huang, DJ
   Jiang, W
AF Zhu, Ye
   Shi, Ya-Ping
   Wu, Dan
   Ji, Ya-Jing
   Wang, Xue
   Chen, Hua-Li
   Wu, Si-Si
   Huang, De-Jia
   Jiang, Wei
TI Salidroside Protects Against Hydrogen Peroxide-Induced Injury in Cardiac
   H9c2 Cells via PI3K-Akt Dependent Pathway
SO DNA AND CELL BIOLOGY
LA English
DT Article
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; APOPTOSIS; ACTIVATION;
   EXPRESSION; HEART; RAT
AB Oxidative stress induces serious tissue injury in cardiovascular diseases. Salidroside, with its strong antioxidative and cytoprotective actions, is of particular interest in the development of antioxidative therapies for oxidative injury in cardiac diseases. We examined the pharmacological effects of salidroside on H9c2 rat cardiomyoblast cells under conditions of oxidative stress induced by hydrogen peroxide (H2O2) challenge. Salidroside attenuated H2O2-impaired cell viability in a concentration-dependent manner, and effectively inhibited cellular malondialdehyde production, lethal sarcolemmal disruption, cell necrosis, and apoptosis induced by H2O2 insult. Salidroside significantly augmented Akt phosphorylation at Serine 473 in the absence or presence of H2O2 stimulation; wortmannin, a specific inhibitor of PI3K, abrogated salidroside protection. Salidroside increased the intracellular mRNA expression and activities of catalase and Mn-superoxide dismutases in a PI3K-dependent manner. Our results indicated that salidroside protected cardiomyocytes against oxidative injury through activating the PI3K/Akt pathway and increasing the expression and activities of endogenous PI3K dependent antioxidant enzymes.
C1 [Zhu, Ye; Shi, Ya-Ping; Wu, Dan; Ji, Ya-Jing; Wang, Xue; Chen, Hua-Li; Wu, Si-Si; Huang, De-Jia; Jiang, Wei] Sichuan Univ, Dept Cardiol, Mol Med Res Ctr, W China Hosp, Chengdu 610041, Sichuan, Peoples R China.
   [Wu, Dan; Ji, Ya-Jing; Wang, Xue; Chen, Hua-Li; Jiang, Wei] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China.
   [Shi, Ya-Ping] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Chengdu University of
   Traditional Chinese Medicine
RP Jiang, W (corresponding author), Sichuan Univ, Dept Cardiol, Mol Med Res Ctr, W China Hosp, Chengdu 610041, Sichuan, Peoples R China.
EM jwhx89@163.com; wcumsjw72@hotmail.com
FU Administration of Traditional Chinese Medicine of Sichuan [2008-36];
   Sichuan Science and Technology Bureau [2009FZ0067, 2010SZ0081]; National
   Natural Science Foundation of China [30871017, 31071001, 81000056]
FX This work was supported by a foundation for youths (2008-36) from
   Administration of Traditional Chinese Medicine of Sichuan to Dr. Y Zhu,
   the Key Projects in the Science and Technology Pillar Program from
   Sichuan Science and Technology Bureau (2009FZ0067 to Dr. W. Jiang and
   2010SZ0081 to Dr. Y. Zhu), and the National Natural Science Foundation
   of China (30871017 and 31071001 to Dr. W. Jiang and 81000056 to Dr. S.S.
   Wu).
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NR 29
TC 73
Z9 85
U1 0
U2 27
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5498
EI 1557-7430
J9 DNA CELL BIOL
JI DNA Cell Biol.
PD OCT
PY 2011
VL 30
IS 10
BP 809
EP 819
DI 10.1089/dna.2010.1183
PG 11
WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
GA 827AK
UT WOS:000295396900008
PM 21563965
DA 2026-05-27
ER

PT J
AU Fei, SF
   Hou, C
   Jia, F
AF Fei, Si-Fan
   Hou, Can
   Jia, Fang
TI Effects of salidroside on atherosclerosis: potential contribution of gut
   microbiota
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE salidroside; atherosclerosis; gut microbiota; trimethylamine noxide;
   lipopolysaccharide; short-chain fatty acids
ID RAT PLASMA; RHODIOLA-CRENULATA; METABOLIC PROFILE; RISK-FACTORS;
   LIPOPOLYSACCHARIDE; INFLAMMATION; DEFENSINS; MICE
AB Much research describes gut microbiota in atherosclerotic cardiovascular diseases (ASCVD) for that the composition of the intestinal microbiome or its metabolites can directly participate in the development of endothelial dysfunction, atherosclerosis and its adverse complications. Salidroside, a natural phenylpropane glycoside, exhibits promising biological activity against the progression of ASCVD. Recent studies suggested that the gut microbiota played a crucial role in mediating the diverse beneficial effects of salidroside on health. Here, we describe the protective effects of salidroside against the progression of atherosclerosis. Salidroside regulates the abundance of gut microbiotas and gut microbe-dependent metabolites. Moreover, salidroside improves intestinal barrier function and maintains intestinal epithelial barrier function integrity. In addition, salidroside attenuates the inflammatory responses exacerbated by gut microbiota disturbance. This review delves into how salidroside functions to ameliorate atherosclerosis by focusing on its interaction with gut microbiota, uncovering the potential roles of gut microbiota in the diverse biological impacts of salidroside.
   This review seeks to offer a comprehensive look at how salidroside impacts gut microbiota and its potential therapeutic role in treating atherosclerosis. (A) Salidroside has been shown to have a positive impact on atherosclerosis by promoting the growth of beneficial bacteria and decreasing the levels of harmful bacteria in the body. (B) Salidroside has been shown to enhance the integrity and function of the intestinal mucosal barrier through its ability to suppress NF-kappa B and p38 MAPK signaling pathways, modulate the NF-kappa B/MAPK/JAK-STAT3 signaling pathways and increase the expression of antimicrobial peptides HD-5 and HD-6. (C) Salidroside can reduce TMAO production through reducing the abundance of Firmicutes and Proteobacteria. (D) Salidroside can improve the expression of SCFAs, through increasing the abundance of some special bacteria. (E) Salidroside can reduce LPS-induced inflammation, which is associated with the inhibition of the ROS-mediated PI3K/AKT/mTOR signaling pathway, the downregulation of exosome miR-199a-5p, and the attenuation of the Notch-Hes signaling pathway. (F) Salidroside can inhibit NLRP3-associated gut-coronary axis, including TLR4/MyD88/NF-kappa B/NLRP3 signaling pathway, AMPK/NF-kappa B/NLRP3 signaling pathway, and P2X7/NF-kappa B/NLRP3 signaling pathway.
C1 [Fei, Si-Fan; Hou, Can; Jia, Fang] Soochow Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Cardiovasc Med, Changzhou, Peoples R China.
C3 Soochow University - China
RP Jia, F (corresponding author), Soochow Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Cardiovasc Med, Changzhou, Peoples R China.
EM jiafangsjs@126.com
FU Major Technology Projects of Changzhou Health Commission [ZD202212]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by Major Technology Projects of Changzhou Health Commission
   (Grant numbers ZD202212).
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NR 123
TC 5
Z9 6
U1 6
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 17
PY 2024
VL 15
AR 1400981
DI 10.3389/fphar.2024.1400981
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA A3X4Y
UT WOS:001281894100001
PM 39092226
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ju, LJ
   Wen, XH
   Wang, CJ
   Wei, YJ
   Peng, YR
   Ding, YF
   Feng, L
   Shu, L
AF Ju, Linjie
   Wen, Xiaohua
   Wang, Chunjun
   Wei, Yingjie
   Peng, Yunru
   Ding, Yongfang
   Feng, Liang
   Shu, Luan
TI Salidroside, A Natural Antioxidant, Improves β-Cell Survival and
   Function via Activating AMPK Pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE type 2 diabetes; beta-cells; salidroside; oxidative stress; AMPK
ID OXIDATIVE STRESS; NADPH OXIDASE; PROTEIN-KINASE; INDUCED APOPTOSIS;
   GLUCOSE TOXICITY; FASTING GLYCEMIA; DIABETIC MICE; ER STRESS;
   PI3K/AKT/FOXO1; MECHANISM
AB Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces beta-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on beta-cells against diabetes associated oxidative stress.
   Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased beta-cell mass and beta-cell replication of diabetic mice. Mechanism study in Min6 cells revealed that, under diabetic stimuli, salidroside suppressed reactive oxygen species production and restore mitochondrial membrane potential (1 9 m) via reducing NOX2 expression and inhibiting JNK-caspase 3 apoptotic cascade subsequently to protect beta-cell survival. Simultaneously, diabetes associated oxidative stress also activated FOXO1 and triggered nuclear exclusion of PDX1 which resulted in beta-cell dysfunction. This deleterious result was reversed by salidroside by activating AMPK-AKT to inhibit FOXO1 and recover PDX1 nuclear localization. The efficacy of salidroside in improving beta-cell survival and function was further confirmed in isolated cultured mouse islets. Moreover, the protective effects of salidroside on beta-cells against diabetic stimuli can be abolished by an AMPK inhibitor compound C, which indicated functions of salidroside on beta-cells were AMPK activation dependent.
   Conclusion: These results confirmed beneficial metabolic effects of salidroside and identified a novel role for salidroside in preventing beta-cell failure via AMPK activation. Our finding highlights the potential value of Rhodiola rosea as a dietary supplement for diabetes control.
C1 [Ju, Linjie; Wen, Xiaohua; Wang, Chunjun; Wei, Yingjie; Peng, Yunru; Ding, Yongfang; Feng, Liang; Shu, Luan] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing, Jiangsu, Peoples R China.
   [Ju, Linjie; Wen, Xiaohua; Wang, Chunjun; Wei, Yingjie; Feng, Liang; Shu, Luan] Jiangsu Prov Acad Chinese Med, Key Lab New Drug Delivery Syst Chinese Mat Med, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Shu, L (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing, Jiangsu, Peoples R China.; Shu, L (corresponding author), Jiangsu Prov Acad Chinese Med, Key Lab New Drug Delivery Syst Chinese Mat Med, Nanjing, Jiangsu, Peoples R China.
EM shuluan2006@hotmail.com
RI wen, xiaohua/PFZ-3465-2026
FU Natural Science Foundation of China [81102488, 81370924]; EFSD/CDS/Lilly
   Program for Collaborative Research between China and Europe; Foundation
   for High-Level Talent in Six Areas of Jiangsu Province [2015-YY010];
   Jiangsu Provincial Natural Science Foundation of China [BK20151606]
FX This work was supported by the Natural Science Foundation of China
   (Grant Nos. 81102488, 81370924), EFSD/CDS/Lilly Program for
   Collaborative Research between China and Europe, the Foundation for
   High-Level Talent in Six Areas of Jiangsu Province (Grant No.
   2015-YY010), and the Jiangsu Provincial Natural Science Foundation of
   China (BK20151606).
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NR 35
TC 70
Z9 73
U1 1
U2 44
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 18
PY 2017
VL 8
AR 749
DI 10.3389/fphar.2017.00749
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FJ9ZQ
UT WOS:000413140400001
PM 29093682
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, YJ
   Wang, JY
   Wang, L
   Zhang, C
   Bai, QX
   Lyu, XM
   Yang, RJ
AF Liu, Yingjie
   Wang, Jieyu
   Wang, Lu
   Zhang, Cheng
   Bai, Qingxiang
   Lyu, Xiaomei
   Yang, Ruijin
TI Biosynthesis and biotechnological production of salidroside from
   Rhodiola genus plants
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Article
DE Salidroside; Sustainable production; Biosynthesis pathway; Metabolic
   engineering; Product development
ID CELL-SUSPENSION CULTURES; APPLE SEED MEAL; IN-VITRO;
   SACCHAROMYCES-CEREVISIAE; MICROBIAL-PRODUCTION; ASSISTED EXTRACTION;
   FEEDBACK INHIBITION; NATURAL-PRODUCTS; IONIC LIQUID; ROSEA L.
AB Salidroside is a precious phenylethanoid glycoside derived from Rhodiola genus plants, which possesses a broad spectrum of biological properties for application in the cosmetic, medical and food fields. As the supply of salidroside is severely subject to the natural Rhodiola sources, sustainable production of salidroside with more economical and effective approaches has become a research hotspot in recent years. In this review, the biosynthesis pathways and enzymes involved in salidroside production in plants were elucidated in depth. Furthermore, efforts towards enhancement of salidroside production, including cell and tissue culture, enzymatic catalysis, metabolic engineering of micro-organisms were introduced comprehensively. Lastly, the strategies for product development of salidroside are presented with discussions on future prospects for the biosynthesis of salidroside. Given that there is still a certain distance between the current microbial productivity and industrialization requirement, more wisdom is in demand for dynamic regulation of cell growth and product accumulation, specific adsorption of the target compound as well as utilization of more economical carbon sources, so as to boost industrialization of salidroside via microbial fermentation.
C1 [Liu, Yingjie; Wang, Jieyu; Wang, Lu; Zhang, Cheng; Bai, Qingxiang; Lyu, Xiaomei; Yang, Ruijin] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
C3 Jiangnan University
RP Lyu, XM; Yang, RJ (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
EM xmlyu@jiangnan.edu.cn; yrj@jiangnan.edu.cn
RI Zhang, Cheng/AAE-5055-2019
FU National Key Research and Development Program of China [2021YFC2100700];
   National Natural Science Foundation of China [22108097]; Natural Science
   Foundation of Jiangsu Province [BK20200616]; China Postdoctoral Science
   Foundation [2020M671339]; Innovative and Entrepreneurial Doctor of
   Jiangsu Province [1026010241203190]
FX This work was funded by the National Key Research and Development
   Program of China (2021YFC2100700), National Natural Science Foundation
   of China (22108097), Natural Science Foundation of Jiangsu Province
   (BK20200616), China Postdoctoral Science Foundation (2020M671339), and
   Innovative and Entrepreneurial Doctor of Jiangsu Province
   (1026010241203190).
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NR 103
TC 17
Z9 21
U1 11
U2 203
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1568-7767
EI 1572-980X
J9 PHYTOCHEM REV
JI Phytochem. Rev.
PD OCT
PY 2022
VL 21
IS 5
BP 1605
EP 1626
DI 10.1007/s11101-021-09800-1
EA JAN 2022
PG 22
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 5F1XF
UT WOS:000739282400001
DA 2026-05-27
ER

PT J
AU Chen, GD
   Fan, H
   Zhu, JH
AF Chen, Guo-dong
   Fan, Heng
   Zhu, Jian-Hua
TI Salidroside pretreatment protects against myocardial injury induced by
   heat stroke in mice
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Salidroside; heat stroke; myocardial injury; systemic inflammatory
   response; oxidative stress; cytokine
ID OXIDATIVE STRESS; CARDIOMYOCYTES; APOPTOSIS
AB Objective To explore the protective effects and mechanisms of salidroside on myocardial injury induced by heat stroke (HS) in mice. Methods We pretreated mice with salidroside for 1 week and then established an HS model by exposure to 41.2 degrees C for 1 hour. We then examined the effects of salidroside on survival. We also assessed the severity of cardiac injury by pathology, and analyzed changes in levels of myocardial injury markers, inflammatory cytokines, and oxidative stress. Results Salidroside pretreatment significantly reduced HS-induced mortality and improved thermoregulatory function. Salidroside also provided significant protection against HS-induced myocardial damage, and decreased the expression levels of cardiac troponin I, creatine kinase-MB, and lactate dehydrogenase. Moreover, salidroside attenuated HS-induced changes in the inflammation markers tumor necrosis factor-alpha, interleukin (IL)-6, and IL-10, and down-regulated the oxidative stress response indicated by thiobarbituric acid reactant substances, malondialdehyde, reduced glutathione, and superoxide dismutase. Conclusions Salidroside pretreatment protected against HS-induced myocardial damage, potentially via a mechanism involving anti-inflammatory and anti-oxidative effects.
C1 [Chen, Guo-dong; Fan, Heng; Zhu, Jian-Hua] Ningbo First Hosp, Dept Intens Care Unit, 59 Liuting Rd, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University
RP Zhu, JH (corresponding author), Ningbo First Hosp, Dept Intens Care Unit, 59 Liuting Rd, Ningbo, Zhejiang, Peoples R China.
EM zhujianhua201107@163.com
OI Zhu, Jian-hua/0000-0003-0780-7168
FU Zhejiang Natural Science Fund [LQ18H150001]; Zhejiang Provincial Medical
   and Health Science Fund [2018KY667, 2018KY669, 2018KY685]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by the Zhejiang Natural Science Fund (LQ18H150001) and the
   Zhejiang Provincial Medical and Health Science Fund (2018KY667,
   2018KY669, 2018KY685).
CR Chatterjee S, 2005, SHOCK, V24, P341, DOI 10.1097/01.shk.0000180983.55623.2b
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NR 20
TC 13
Z9 17
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD OCT
PY 2019
VL 47
IS 10
BP 5229
EP 5238
AR 0300060519868645
DI 10.1177/0300060519868645
EA AUG 2019
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JG3AA
UT WOS:000484091700001
PM 31448659
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, J
   Xuan, JT
   He, ZY
   Zhang, SJ
   Zhou, J
   Liu, HL
   Xia, ZY
   Wu, Y
   Chen, S
   Wu, BM
   Li, HS
AF Zhang, Jun
   Xuan, Jintao
   He, Zheyun
   Zhang, Sijia
   Zhou, Jing
   Liu, Hongliang
   Xia, Zhanyang
   Wu, Yuan
   Chen, Si
   Wu, Boming
   Li, Hongshan
TI Salidroside alleviates early-stage MASH through the PPARγ-mediated
   inflammatory signaling pathway
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; MASH; PPAR gamma; NF-kappa B
ID DISEASE
AB Ethnopharmacological relevance: Rhodiola rosea, a traditional Chinese medicinal herb, has long been prized for enhancing energy metabolism and reducing inflammation. Salidroside, the primary bioactive component of Rhodiola rosea, has shown promising protective effects against MASH. However, the mechanisms through which salidroside alleviates MASH remain unclear. Aim of the study: This study evaluated the therapeutic effects and underlying mechanisms of salidroside in MASH. Materials and methods: MASH was induced in mice via CDAHFD feeding, after which the mice were treated with salidroside daily for four weeks. To investigate the therapeutic potential and underlying mechanisms of salidroside in MASH, we employed biochemical assays, H&E staining, transcriptomics, metabolomics, network pharmacology, molecular docking, and Western blotting. The role of PPAR gamma was further investigated using the inhibitor GW9662. Results: Salidroside significantly reduced hepatic lipid accumulation, serum ALT and AST levels, and NAS scores, and ameliorated inflammatory infiltration in MASH mice. Transcriptomic and metabolomic analyses revealed enrichment in the PPAR signaling pathway. Integrated multiomics and network pharmacology revealed PPAR gamma as a core target. Molecular docking confirmed strong binding between salidroside and PPAR gamma. Treatment with salidroside upregulated PPAR gamma expression and suppressed NF-kappa B phosphorylation and proinflammatory cytokine production. Cotreatment with GW9662 abolished these protective effects. Conclusion: Salidroside alleviates MASH by activating PPAR gamma and inhibiting the NF-kappa B inflammatory pathway, thereby reducing hepatic lipid deposition and inflammation. These results demonstrate the potential of salidroside as a promising therapeutic agent for MASH.
C1 [Zhang, Jun; Xuan, Jintao; Zhou, Jing; Liu, Hongliang; Xia, Zhanyang; Wu, Yuan; Chen, Si; Wu, Boming; Li, Hongshan] Ningbo 2 Hosp, Liver Dis Dept Integrat Med, Ningbo 315010, Zhejiang, Peoples R China.
   [Zhang, Jun] Jiaxing Univ, Affiliated Hosp, Hosp Jiaxing 1, Dept Infect Dis, Jiaxing 314000, Zhejiang, Peoples R China.
   [Xuan, Jintao] Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315300, Zhejiang, Peoples R China.
   [He, Zheyun] Ningbo 2 Hosp, Liver Dis Inst, Ningbo 315000, Zhejiang, Peoples R China.
   [Zhang, Sijia; Li, Hongshan] Ningbo 2 Hosp, Med Expt Dept, Ningbo 315000, Zhejiang, Peoples R China.
C3 Jiaxing University; Wenzhou Medical University
RP Li, HS (corresponding author), 41 XiBei St, Ningbo 315010, Zhejiang, Peoples R China.
EM lihongshan_1982@126.com
FU Zhejiang Provincial Natural Science Foundation of China [LY23H290004];
   Ningbo Natural Science Foundation [2021J317]; Major Special Science and
   Technology Project of Ningbo City [2022Z128, GZY-ZJ-KJ-23092]; Zhejiang
   Province Traditional Chinese Medicine Science and Technology Plan
   [2022ZB332]; Project of Ningbo Leading Medical & Health Discipline
   [2022Z01]; Medical Scientific Research Foundation of Zhejiang Prov-ince
   [2022KY1123]; Ningbo Medical Science and Technology Plan Project
   [2021Y11]
FX This work was supported by the Zhejiang Provincial Natural Science
   Foundation of China under Grant (LY23H290004) , Ningbo Natural Science
   Foundation (2022J242) , Major Special Science and Technology Project of
   Ningbo City (2022Z128) , National Administration of Tradi-tional Chinese
   Medicine-Zhejiang Provincial Administration of Tradi-tional Chinese
   Medicine Joint Construction Technology Plan (GZY-ZJ-KJ-23092) , Zhejiang
   Province Traditional Chinese Medicine Science and Technology Plan
   (2022ZB332) , Project of Ningbo Leading Medical & Health Discipline
   (2022Z01) , Ningbo Natural Science Foundation (2021J317) , Medical
   Scientific Research Foundation of Zhejiang Prov-ince (2022KY1123) ,
   Ningbo Medical Science and Technology Plan Project (2021Y11) .
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NR 40
TC 0
Z9 0
U1 10
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAR 1
PY 2026
VL 358
AR 121045
DI 10.1016/j.jep.2025.121045
EA DEC 2025
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA AA0XP
UT WOS:001643235200001
PM 41397540
DA 2026-05-27
ER

PT J
AU Ren, M
   Xu, WJ
   Xu, T
AF Ren, Mei
   Xu, Wenjing
   Xu, Tao
TI Salidroside represses proliferation, migration and invasion of human
   lung cancer cells through AKT and MEK/ERK signal pathway
SO ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
LA English
DT Article
DE Lung cancer; salidroside; AKT; MEK; ERK; miR-195
ID RHODIOLA-ROSEA L.; MAP KINASE; CYCLIN D1; PROGRESSION; INHIBITION;
   ACTIVATION; EXPRESSION; APOPTOSIS; PROTECTS; GROWTH
AB Salidroside, a glycoside of tyrosol, is isolated from Rhodiola rosea and shows anti-cancer functions in several cancers. However, the potentials of salidroside in the migration and invasion of lung cancer cells and its underlying mechanisms remain unknown. We aimed to investigate the functions and mechanisms of salidroside in non-small cell lung cancer (NSCLC). Human NSCLC cell line A549 was treated with different doses of salidroside. Cell viability, colony formation, apoptosis, migration and invasion were detected by CCK-8, crystal violet-staining assay, flow cytometry and transwell assay, respectively. qRT-PCR and western blot analysis were performed to assess the regulatory effects of salidroside on miR-195 expression and the activation of AKT and the MEK/ERK signal pathway. We found that, salidroside remarkably reduced cell viability, colony formation and Cyclin D1 expression, but increased p21 expression and apoptosis in A549 cells. Additionally, salidroside inhibited the migration and invasion of A549 cells by regulating expressions of migration- and invasion-related proteins. Finally, salidroside inhibited phosphorylation of AKT, MEK and ERK by upregulating miR-195 expression in A549 cells. In conclusion, salidroside inhibited the survival, migration and invasion of NSCLC cells. Salidroside blocked AKT and the MEK/ERK signal pathway by upregulating miR-195 expression in A549 cells.
C1 [Ren, Mei] Jining 1 Peoples Hosp, Dept Oncol, Jining, Peoples R China.
   [Xu, Wenjing] Jining 1 Peoples Hosp, Dept Chinese Med, Jining, Peoples R China.
   [Xu, Tao] Qingdao Univ, Dept Resp Med, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
C3 Qingdao University
RP Xu, T (corresponding author), Qingdao Univ, Dept Resp Med, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
EM xutao2213@sina.com
RI tao, xu/E-7171-2019
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NR 40
TC 46
Z9 60
U1 1
U2 49
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2169-1401
EI 2169-141X
J9 ARTIF CELL NANOMED B
JI Artif. Cell. Nanomed. Biotechnol.
PY 2019
VL 47
IS 1
BP 1014
EP 1021
DI 10.1080/21691401.2019.1584566
PG 8
WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Materials
   Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering; Materials Science
GA HP1OD
UT WOS:000461435400001
PM 30880481
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, G
   Li, N
   Zhao, Y
   Wang, W
   Feng, XL
AF Yu, Ge
   Li, Na
   Zhao, Yan
   Wang, Wei
   Feng, Xiao-Ling
TI Salidroside induces apoptosis in human ovarian cancer SKOV3 and A2780
   cells through the p53 signaling pathway
SO ONCOLOGY LETTERS
LA English
DT Article
DE salidroside; apoptosis; p53 signaling pathway; ovarian cancer
ID RHODIOLA-ROSEA; IN-VITRO; DOUBLE-BLIND; RECEPTOR; GROWTH; PROLIFERATION;
   PATHOGENESIS; MIGRATION; FATIGUE; EXTRACT
AB Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea, and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on the proliferation and apoptosis of SKOV3 and A2780 cells using MTT assay and acridine orange/ethidium bromide staining. Salidroside activated caspase-3 and upregulated the levels of apoptosis-inducing factor, Bcl-2-associated X and Bcl-2-associated death promoter (Bad) proteins. Furthermore, salidroside downregulated the levels of Bcl-2, p-Bad and X-linked inhibitor of apoptosis proteins. Salidroside activated the caspase-dependent pathway in SKOV3 and A2780 cells, upregulating p53, p21(Cip1/Waf1) and p16(INK4a). These results suggest that the p53/p21(Cip1/Waf1)/p16(INK4a) pathway may serve a key function in salidroside-mediated effects on SKOV3 and A2780 cells. The current findings indicate that salidroside may be a promising novel drug candidate for ovarian cancer therapy.
C1 [Yu, Ge; Feng, Xiao-Ling] Heilongjiang Univ Chinese Med, Dept Gynecol Tradit Chinese Med, Harbin 150001, Heilongjiang, Peoples R China.
   [Li, Na; Zhao, Yan; Wang, Wei; Feng, Xiao-Ling] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Gynecol Tradit Chinese Med, 24 He Ping Rd, Harbin 150001, Heilongjiang, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine
RP Feng, XL (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Gynecol Tradit Chinese Med, 24 He Ping Rd, Harbin 150001, Heilongjiang, Peoples R China.
EM doctorfxl@163.com
CR [Anonymous], ANN ONCOL
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NR 36
TC 43
Z9 47
U1 1
U2 26
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD MAY
PY 2018
VL 15
IS 5
BP 6513
EP 6518
DI 10.3892/ol.2018.8090
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GF3DN
UT WOS:000431825900055
PM 29616120
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, XJ
   Lu, Y
   Tao, Y
   Huang, Y
   Wang, DY
   Hu, YL
   Liu, JG
   Wu, Y
   Yu, Y
   Liu, C
AF Zhao, Xiaojuan
   Lu, Yu
   Tao, Yang
   Huang, Yee
   Wang, Deyun
   Hu, Yuanliang
   Liu, Jiaguo
   Wu, Yi
   Yu, Yun
   Liu, Cui
TI Salidroside liposome formulation enhances the activity of dendritic
   cells and immune responses
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside liposomes; Dendritic cells; OVA; Vaccine; Adjuvant
ID DRUG-DELIVERY; PROLIFERATION; EXPRESSION; ADAPTOGENS; ELISA
AB Salidroside, the important composition, of Rhodiola rosea L has been reported to have various pharmacological properties. Liposome is known to be effective as drug carriers and immune adjuvant Therefore, the aim of this study is to investigate immunological adjuvant activity of salidroside liposome. Here we reported the preparation, the effect on DCs in vitro and the immune response in vivo. The immunological adjuvant activity of salidroside liposome formulation was compared with that of salidroside and liposome. The result showed that salidroside liposome formulation not only could promote the maturation of DCs, the stimulation of DCs on MLR proliferation and the antigen presenting ability, but also induced the sustained cellular immune and humoral immune response. Overall, the results showed that salidroside liposome formulation had the potential to act as effective sustained release vaccine delivery systems. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Zhao, Xiaojuan; Tao, Yang; Huang, Yee; Wang, Deyun; Hu, Yuanliang; Liu, Jiaguo; Wu, Yi; Yu, Yun; Liu, Cui] Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China.
   [Zhao, Xiaojuan; Lu, Yu] Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Jiangsu, Peoples R China.
C3 Nanjing Agricultural University; Jiangsu Academy of Agricultural
   Sciences
RP Wang, DY (corresponding author), Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China.
EM dywang@njau.edu.cn
FU National Natural Science Foundation of China [31372472]; Fundamental
   Research Funds for the Central Universities [KYZ201117]; Special Fund
   for Agro-scientific Research in the Public Interest [201303046,
   201302040]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX The project was supported by the National Natural Science Foundation of
   China (Grant No. 31372472), the Fundamental Research Funds for the
   Central Universities (Grant No. KYZ201117), the Special Fund for
   Agro-scientific Research in the Public Interest (Grant Nos. 201303046,
   201302040) and a project funded by the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD). We are
   grateful to all other staff in the Institute of Traditional Chinese
   Veterinary Medicine of Nanjing Agricultural University for their
   assistances in the experiments.
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NR 30
TC 33
Z9 39
U1 6
U2 58
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC
PY 2013
VL 17
IS 4
SI SI
BP 1134
EP 1140
DI 10.1016/j.intimp.2013.10.016
PG 7
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 285FJ
UT WOS:000329378800019
PM 24188805
DA 2026-05-27
ER

PT J
AU Chen, CC
   Wang, YH
   Sun, RY
   Lu, XY
   Xu, YP
   Wang, YQ
   Li, JY
   Wang, HW
   Chen, KW
AF Chen, Cong-Cong
   Wang, Yi-Hong
   Sun, Rong-Yue
   Lu, Xin-Yu
   Xu, Yu-Peng
   Wang, Yong-qiang
   Li, Jiang-Yuan
   Wang, Hong-Wei
   Chen, Ke-Wei
TI Salidroside protects against caerulein with the LPS-induced severe acute
   pancreatitis through suppression of oxidative stress and inflammation in
   mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Salidroside; Severe acute pancreatitis; Nrf2; NF-?B
ID REVISED ATLANTA CLASSIFICATION; NF-KAPPA-B; TISSUE-DAMAGE; INJURY;
   INHIBITION; ACTIVATION; RECRUITMENT; NECROSIS; RATS
AB Severe acute pancreatitis (SAP) is a fatal inflammation with no effective treatment. Salidroside, a monomer isolated from the traditional Chinese medicine Rhodiola, has been shown cytoprotective roles in many inflammation-related diseases. However, whether salidroside plays a protective role in an acute inflammation like SAP in mice is unknown. In this study, we aimed to investigate the molecular mechanism underlying the pancreatic protection of salidroside. The results showed that salidroside attenuated caerulein with the LPS-induced pancreatic injury in a mouse model of SAP. Also, we found that salidroside ameliorated oxidative stress and inflammation responses in SAP mice. Furthermore, SAP mice treated with salidroside were associated with higher phosphorylation levels of Nrf2 and less nuclear accumulation of NF-kappa B p65. We further found that depletion of Nrf2 weakened the protective effect of salidroside in SAP mice. Collectively, salidroside mediated anti-oxidant stress and anti-inflammation in SAP mice partially through the Nrf2/NF-kappa B p65 pathway.
C1 [Chen, Cong-Cong] Zhejiang Univ, Affiliated Jinhua Hosp, Dept Pharm, Sch Med, Jinhua, Zhejiang, Peoples R China.
   [Wang, Yi-Hong; Sun, Rong-Yue] Wenzhou Med Univ, Dept Pediat, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
   [Lu, Xin-Yu; Xu, Yu-Peng; Li, Jiang-Yuan] Wenzhou Med Univ, Clin Med Coll 1, Wenzhou, Zhejiang, Peoples R China.
   [Wang, Yong-qiang; Wang, Hong-Wei] Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
   [Chen, Ke-Wei] Wenzhou Med Univ, Dept Plast Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University; Wenzhou Medical University
RP Wang, HW (corresponding author), Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.; Chen, KW (corresponding author), Wenzhou Med Univ, Dept Plast Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
EM 15258085168@163.com; ckw_wyyy@163.com
RI yihong, wang/PLC-9322-2026
FU Wenzhou Science and Technology bureau [Y20210132]; Research Incubation
   Project of The First Affiliated Hospital of Wenzhou Medical University
   [FHY2019058]
FX This work was supported by Wenzhou Science and Technology bureau
   (Y20210132), Research Incubation Project of The First Affiliated
   Hospital of Wenzhou Medical University (FHY2019058).
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NR 61
TC 7
Z9 9
U1 2
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2022
VL 96
AR 105179
DI 10.1016/j.jff.2022.105179
EA AUG 2022
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5A2AF
UT WOS:000862694200004
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kasprzyk, PG
   Vickery, C
   Ye, ML
   Sewastianik, M
   Gong, W
   Ding, S
   Dziwenka, M
   Mozingo, A
   Valm, K
   Schachner, H
   Weng, JK
AF Kasprzyk, Philip G.
   Vickery, Christopher
   Ye, Mingli
   Sewastianik, Magdalena
   Gong, Wei
   Ding, Sheng
   Dziwenka, Margitta
   Mozingo, Amy
   Valm, Kaiti
   Schachner, Holly
   Weng, Jing-Ke
TI Safety of a Sustainably Produced, Bioengineered, Nature-Identical
   Salidroside Compound
SO NUTRIENTS
LA English
DT Article
DE salidroside; toxicity; safety; NOAEL; Rhodiola
ID MULTIPLE COMPARISONS; VARIANCE
AB Bioactive phytochemicals such as salidroside have been studied to understand the beneficial effects of Rhodiola rosea, an herbaceous plant used in traditional medicine to increase energy and treat a variety of health issues. However, Rhodiola plants are often slow-growing, and many are endangered in their native habitats. Thus, there is a need for safe, alternative supplies of key phytochemicals from Rhodiola. The salidroside subject of this safety study is a synthetic biology product from fermentation of a bioengineered E. coli that produces salidroside. Here, we present comprehensive test results that support the safety of salidroside manufactured via a patented sustainable bioengineering manufacturing process. In vitro bacterial reverse mutation assays with the bioengineered salidroside show no mutagenicity in any of the concentrations tested. In vivo toxicity studies in rats show no adverse effects from the salidroside product. Based on the results of these studies, we conclude that the bioengineered salidroside discussed here is not genotoxic and demonstrates a no-observed-adverse-effect level (NOAEL) at least 2000 mg/kg bw/day in male and female Sprague-Dawley rats. This study supports that the salidroside compound produced using bioengineered E. coli is a viable alternative to salidroside produced from harvested Rhodiola plants for use as a dietary supplement, food ingredient, or potentially as a pharmaceutical product.
C1 [Kasprzyk, Philip G.; Vickery, Christopher; Ye, Mingli; Sewastianik, Magdalena; Gong, Wei; Ding, Sheng; Schachner, Holly; Weng, Jing-Ke] DoubleRainbow Biosci Inc, Lexington, MA 02421 USA.
   [Dziwenka, Margitta; Mozingo, Amy; Valm, Kaiti] GRAS Associates, Nutrasource Pharmaceut & Nutraceut Serv, Guelph, ON N1G 0B4, Canada.
   [Weng, Jing-Ke] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA.
   [Weng, Jing-Ke] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
C3 Massachusetts Institute of Technology (MIT); Whitehead Institute;
   Massachusetts Institute of Technology (MIT)
RP Kasprzyk, PG (corresponding author), DoubleRainbow Biosci Inc, Lexington, MA 02421 USA.
EM kasprzyk@doublerainbowbio.com; chris.vickery@doublerainbowbio.com;
   mingli.ye@doublerainbowbio.com; sewastianik@doublerainbowbio.com;
   weigong01@gmail.com; sheng.ding@doublerainbowbio.com;
   dziwenka@gras-associates.com; amozingo@gras-associates.com;
   kvalm@nutrasource.ca; holly.schachner@doublerainbowbio.com;
   jingke.weng@doublerainbowbio.com
RI Dziwenka, Margitta/ACY-2083-2022; Weng, Jing-Ke/V-5934-2019; ding,
   sheng/LMP-1860-2024; /J-1631-2014
OI Dziwenka, Margitta/0000-0003-4392-3473; 
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NR 32
TC 16
Z9 17
U1 2
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2022
VL 14
IS 11
AR 2330
DI 10.3390/nu14112330
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1Z1LE
UT WOS:000808593700001
PM 35684130
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shi, TY
   Chen, H
   Jing, LL
   Liu, XY
   Sun, XL
   Jiang, R
AF Shi, Tianyao
   Chen, Hui
   Jing, Linlin
   Liu, Xueying
   Sun, Xiaoli
   Jiang, Ru
TI DEVELOPMENT OF A KILOGRAM-SCALE SYNTHESIS OF SALIDROSIDE AND ITS ANALOGS
SO SYNTHETIC COMMUNICATIONS
LA English
DT Article
DE Kilogramscale; salidroside; synthesis; tyrosol glycoside
ID RHODIOLA-ROSEA; PERFORMANCE; EXTRACT
AB An efficient, safe, and viable process has been developed for large-scale preparation of salidroside, a natural product. The process consists of two chemical steps, which produce the salidroside on a multikilogram scale with 72% overall yield and >98% purity. A series of novel salidroside analogs were prepared according to the same method.
C1 [Liu, Xueying; Jiang, Ru] Fourth Mil Med Univ, Dept Med Chem & Pharmaceut Anal, Sch Pharm, Xian 710032, Shaanxi, Peoples R China.
   [Shi, Tianyao; Chen, Hui; Jing, Linlin; Sun, Xiaoli] Fourth Mil Med Univ, Dept Chem, Sch Pharm, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Jiang, R (corresponding author), Fourth Mil Med Univ, Dept Med Chem & Pharmaceut Anal, Sch Pharm, 17 Changle W Rd, Xian 710032, Shaanxi, Peoples R China.
EM jiangru@fmmu.edu.cn
RI sun, xiaoli/O-1630-2018
FU National Natural Science Foundation of China [20972189, 30901883,
   20802091]
FX This work was financially supported by the National Natural Science
   Foundation of China (Nos. 20972189, 30901883, and 20802091).
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NR 13
TC 26
Z9 29
U1 4
U2 54
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0039-7911
J9 SYNTHETIC COMMUN
JI Synth. Commun.
PY 2011
VL 41
IS 17
BP 2594
EP 2600
DI 10.1080/00397911.2010.515332
PG 7
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC); Current Chemical Reactions (CCR-EXPANDED)
SC Chemistry
GA 860VF
UT WOS:000297975500012
DA 2026-05-27
ER

PT J
AU Zhu, FC
   Yan, ZX
   Zhao, KX
   Li, XL
   Ma, JB
   Zhang, XH
   Zang, YJ
AF Zhu, Fucheng
   Yan, Zixu
   Zhao, Kexue
   Li, Xiaoli
   Ma, Jingbo
   Zhang, Xinhong
   Zang, Yongjun
TI Engineering of Glycosyltransferase for Efficient Biosynthesis of
   Salidroside
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE salidroside; semirationaldesign; cascade reaction; precise catalysis
ID GLYCOSYLATION
AB Salidroside has been widely used in the cosmetic and medicinal industries. Previously, potential glycosyltransferase UGTBS was obtained for salidroside synthesis. However, the catalytic efficiency for salidroside was undesirable. In this study, a semirational design was applied to engineer UGTBS. The quadruple mutant M4 (I62N/S129T/F168W/Y316S) showed significantly enhanced salidroside synthesis. A conversion rate of 94.7% was obtained using mutant M4, which was 2.2-fold higher than that of the wild-type. The regioselectivity of mutant M4 toward tyrosol hydroxyl was also improved, resulting in 97.9% salidroside in the total product, which was 1.2-fold higher than that of the wild type. Kinetic constants and molecular simulations indicated that increased affinity and altered conformation of the binding pocket accounted for the enhanced salidroside synthesis. Furthermore, a fed-batch cascade reaction strategy was used, and over 183 mM salidroside was obtained. The engineered mutant M4 demonstrated precise catalysis for salidroside formation.
C1 [Zhu, Fucheng; Yan, Zixu; Zhao, Kexue; Li, Xiaoli; Ma, Jingbo; Zang, Yongjun] West Anhui Univ, Coll Biol & Pharmaceut Engn, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Anhui Prov Key Lab Qual Evaluat & Improvement Trad, Luan 237012, Peoples R China.
   [Zhang, Xinhong] Hefei Univ, Sch Biol Food & Environm, Hefei 230069, Peoples R China.
   [Yan, Zixu; Zhao, Kexue; Li, Xiaoli] Anhui Univ Tradit Chinese Med, Sch Pharm, Hefei 230012, Peoples R China.
C3 West Anhui University; Hefei University; Anhui University of Chinese
   Medicine
RP Zhu, FC; Zang, YJ (corresponding author), West Anhui Univ, Coll Biol & Pharmaceut Engn, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Anhui Prov Key Lab Qual Evaluat & Improvement Trad, Luan 237012, Peoples R China.; Zhang, XH (corresponding author), Hefei Univ, Sch Biol Food & Environm, Hefei 230069, Peoples R China.
EM fucheng323@163.com; zxhong861209@163.com; zangyongjun@yeah.net
RI Li, Xiaoli/C-9739-2012
FU National Natural Science Foundation of China [32201979]; National
   Natural Science Foundation of China [2023AH030109]; Anhui University
   Scientific Research Project Outstanding Youth Project [YQZD2023071];
   Anhui Province Excellent Young Teacher Training Project [2022AH010090];
   Anhui Scientific Research and Innovation Team for Quality Evaluation and
   Improvement of Traditional Chinese Medicine
FX This research was supported by the National Natural Science Foundation
   of China (32201979), the Anhui University Scientific Research Project
   Outstanding Youth Project (2023AH030109), the Anhui Province Excellent
   Young Teacher Training Project (YQZD2023071), and the Anhui Scientific
   Research and Innovation Team for Quality Evaluation and Improvement of
   Traditional Chinese Medicine (2022AH010090).
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PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAR 28
PY 2025
VL 73
IS 14
BP 8448
EP 8457
DI 10.1021/acs.jafc.5c00488
EA MAR 2025
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 1DV3O
UT WOS:001455032300001
PM 40152664
DA 2026-05-27
ER

PT J
AU Li, H
   Huang, DL
   Hang, SY
AF Li, Hai
   Huang, Delian
   Hang, Shiying
TI RETRACTED: Salidroside inhibits the growth, migration and invasion of
   Wilms' tumor cells through down-regulation of miR-891b (Retracted
   article. See vol. 304, 2022)
SO LIFE SCIENCES
LA English
DT Article; Retracted Publication
DE Salidroside; Wilms' tumor; WIT49 cells; RM1 cells; miR-891b
ID NF-KAPPA-B; EXPRESSION; PROLIFERATION; MICRORNAS; APOPTOSIS; CANCER
AB Aims: Salidroside is a major functional component of Rhodiola rosea L. with a lot of pharmacological effects, including anti-tumor. The present work aimed to explore whether Salidroside could also exhibit anti-tumor functions in Wilms' tumor.
   Main methods: WIT49 and RM1 cells were treated by various doses of Salidroside. CCK-8 assay, flow cytometry detection, colony formation assay, Transwell assay, RT-qPCR and Western blot analysis were conducted to measure WIT49 and RM1 cells proliferation, apoptosis, migration and invasion. The expression changes of miR-891b in response to Salidroside treatment were tested by RT-qPCR. Rescue assays were performed to test whether miR-891b was a downstream effector of Salidroside. Finally, the involvement of PI3K/AKT/mTOR and NF-kappa B signaling pathways was studied.
   Key findings: Salidroside with concentration of 80 mu M significantly reduced WIT49 and RM1 cells viability, survival capacity, migration and invasion, and significantly induced apoptosis. Meanwhile, down-regulation of Cyclin D1, MMP-2 and Vimentin, up-regulations of p53 and p21, as well as cleavage of caspase-3 and -9 were observed in Salidroside-treated cell. miR-891b was down-regulated by Salidroside. And Salidroside did not suppress WIT49 and RM1 cells growth, migration and invasion when miR-891b was overexpressed. Also, the deactivation of PI3K/AKT/mTOR and NF-kappa B pathways induced by Salidroside was reversed by miR-891b overexpression.
   Significance: Salidroside inhibits Wilms' tumor cells growth, migration and invasion via down-regulating miR-891b, which leads to the deactivation of PI3K/AKT/mTOR and NF-kappa B signaling pathways.
C1 [Li, Hai; Hang, Shiying] Jining 1 Peoples Hosp, Dept Pediat Surg, 6 Jiankang Rd, Jining 272011, Peoples R China.
   [Huang, Delian] Tradit Chinese Med Hosp Jining, Dept Emergency, Jining 272000, Peoples R China.
RP Hang, SY (corresponding author), Jining 1 Peoples Hosp, Dept Pediat Surg, 6 Jiankang Rd, Jining 272011, Peoples R China.
EM hangshiying123@sina.com
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NR 42
TC 17
Z9 23
U1 3
U2 35
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 1
PY 2019
VL 222
BP 60
EP 68
DI 10.1016/j.lfs.2019.02.052
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HP1IU
UT WOS:000461421000008
PM 30822424
DA 2026-05-27
ER

PT J
AU Ji, ST
   Chen, DY
   Ding, F
   Gu, XS
   Xue, Q
   Zhou, C
   Cao, MH
   Yu, S
AF Ji, Shengtao
   Chen, Daiyue
   Ding, Fei
   Gu, Xiaosong
   Xue, Qiu
   Zhou, Chun
   Cao, Maohong
   Yu, Shu
TI Salidroside exerts neuroprotective effects on retrograde neuronal death
   following neonatal axotomy via activation of PI3K/Akt pathway and
   deactivation of p38 MAPK pathway
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Salidroside; Neonatal axotomy; Neuroprotection; Retrograde neuronal
   death; PI3K/Akt; p38 MAPK
ID PERIPHERAL-NERVE INJURY; SPINAL-CORD; SCIATIC-NERVE; MOTONEURON LOSS;
   MOTOR-NEURONS; SURVIVAL; REGENERATION; GDNF; STRATEGIES; PROTOCOLS
AB Salidroside, a glucoside of tyrosol, is a powerful active ingredient extracted from the Chinese herb medicine Rhodiola rosea L.. As a neuroprotective agent, the application of salidroside in combination with neural tissue engineering has recently attracted much attention in peripheral nerve repair and reconstruction. However, the cellular and molecular mechanisms by which salidroside promotes nerve regeneration remain to be elucidated. We aim to evaluate the long-term neuroprotective potential of salidroside in an experimental rat model of neonatal sciatic nerve crush injury, with a focus on target-deprived neuronal death and the mechanisms involved. Behavioral analysis showed that salidroside dose-dependently improved voluntary hindlimb behavior and rod rotation ability following neonatal axotomy during an 8-week observation period. According to electrophysiology, Fluoro-Gold retrograde tracing, histological and immunohistochemical analyses, salidroside significantly improved nerve regeneration and reinnervation. Nissle and TUNEL staining, as well as caspase-3 activation assay indicated a beneficial effect of salidroside on retrograde loss and apoptosis of motoneurons within 2 weeks after axotomy. qPCR, ELISA and oxidative stress experiments revealed that salidroside improved the imbalance of spinal microenvironment, including oxidative stress and down-regulation of neurotrophic factors. Western blotting analysis showed that salidroside enhanced the activation of PI3K/Akt and inhibited the p38 MAPK signaling pathway following axotomy. The oxidative stress and axonal disconnection/regeneration models of primary motoneurons in vitro further confirmed the involvement of these two pathways in the neuroprotective effects of salidroside. These data provide a theoretical basis for the application of salidroside in peripheral nerve repair and reconstruction.
C1 [Ji, Shengtao; Chen, Daiyue; Ding, Fei; Gu, Xiaosong; Xue, Qiu; Zhou, Chun; Cao, Maohong; Yu, Shu] Nantong Univ, Key Lab Neuroregenerat Jiangsu, Nantong, Peoples R China.
   [Ji, Shengtao; Chen, Daiyue; Ding, Fei; Gu, Xiaosong; Xue, Qiu; Zhou, Chun; Cao, Maohong; Yu, Shu] Nantong Univ, Affiliated Hosp,Minist Educ, Med Sch,Dept Neurol, Co Innovat Ctr Neuroregenerat,NMPA Key Lab Res & E, Nantong, Peoples R China.
   [Xue, Qiu] Nantong Univ, Nantong Tumor Hosp, Nantong Peoples Hosp 5, Dept Gen Surg,Affiliated Tumor Hosp, Nantong, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Zhou, C; Cao, MH; Yu, S (corresponding author), Nantong Univ, Key Lab Neuroregenerat Jiangsu, Nantong, Peoples R China.; Zhou, C; Cao, MH; Yu, S (corresponding author), Nantong Univ, Affiliated Hosp,Minist Educ, Med Sch,Dept Neurol, Co Innovat Ctr Neuroregenerat,NMPA Key Lab Res & E, Nantong, Peoples R China.
EM wyc2578@sina.com; cmhongnt@sina.com; yushu@ntu.edu.cn
FU National Natural Science Foundation of China [81401094]; Priority
   Academic Program Development (PAPD) of Jiangsu Higher Education
   Institutions
FX This work was supported by National Natural Science Foundation of China
   (grant numbers 81401094) , and Priority Academic Program Development
   (PAPD) of Jiangsu Higher Education Institutions.
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NR 54
TC 6
Z9 7
U1 3
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN
PY 2025
VL 494
AR 117178
DI 10.1016/j.taap.2024.117178
EA DEC 2024
PG 16
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA O6W1O
UT WOS:001372495700001
PM 39617258
DA 2026-05-27
ER

PT J
AU Yang, L
   Yu, YN
   Zhang, Q
   Li, XY
   Zhang, CP
   Mao, T
   Liu, SL
   Tian, ZB
AF Yang, Lin
   Yu, Yanan
   Zhang, Qi
   Li, Xiaoyu
   Zhang, Cuiping
   Mao, Tao
   Liu, Siliang
   Tian, Zibin
TI RETRACTED: Anti-gastric cancer effect of Salidroside through elevating
   miR-99a expression (Retracted Article)
SO ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
LA English
DT Article; Retracted Publication
DE Salidroside; miR-99a; gastric cancer (GC); PI3K/AKT pathway; MARK/ERK
   pathway
ID RHODIOLA-ROSEA L.; GASTRIC-CANCER; INVASION; CELLS; PROGNOSIS;
   APOPTOSIS; MIGRATION; EXTRACT; STRESS; GROWTH
AB Salidroside is an active ingredient extracted from Rhodiola rosea that has anti-tumor activities. The current paper attempted to assess the impact of Salidroside on gastric cancer (GC) and explore the potential mechanism. GC cell lines (SNU-216 and MGC803) and gastric epithelial cell line GES-1 were treated with Salidroside. CCK-8 assay, colony formation assay, flow cytometry and Transwell assay were respectively performed to evaluate GC cells phenotype. qRT-PCR and western blot were conducted to reveal the downstream genes and signaling of Salidroside. We found that 800 mu M Salidroside was capable of reducing GC cells viability, while has no such impacts on GES-1 cells. Salidroside inhibited GC cells proliferation, migration, invasion and promoted apoptosis, which coupled with the down-regulation of p21, Bcl-2, MMP2, RhoA, p-ROCK1, Vimentin and the up-regulations of CyclinD1, Bax, cleaved caspases. miR-99a was found to be highly expressed in response to Salidroside treatment. Besides, the inhibition of MAPK/ERK and PI3K/AKT signaling induced by Salidroside was attenuated by miR-99a silence and in this process, IGF1R worked as a target of miR-99a. The anti-GC effect of Salidroside was also confirmed in a mouse model of GC. The promoting effect of Salidroside on miR-99a expression was also verified in vivo. Furthermore, Salidroside promoted the cisplatin-sensitivity of SGC7901/DDP cells. In conclusion, this study demonstrated that Salidroside possessed anti-GC effects through regulating miR-99a/IGF1R axis and inhibiting MAPK/ERK and PI3K/AKT pathways.
C1 [Yang, Lin; Yu, Yanan; Zhang, Qi; Li, Xiaoyu; Zhang, Cuiping; Mao, Tao; Liu, Siliang; Tian, Zibin] Qingdao Univ, Affiliated Hosp, Dept Gastroenterol, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China.
C3 Qingdao University
RP Tian, ZB (corresponding author), Qingdao Univ, Affiliated Hosp, Dept Gastroenterol, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China.
EM tianzibin0004@sina.com
RI Li, Xiaoyu/HSE-9827-2023
FU National Natural Science Foundation of China [81572320, 81502025]
FX This work was supported by the National Natural Science Foundation of
   China [Grant No. 81572320, 81502025].
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NR 42
TC 18
Z9 25
U1 0
U2 21
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2169-1401
EI 2169-141X
J9 ARTIF CELL NANOMED B
JI Artif. Cell. Nanomed. Biotechnol.
PY 2019
VL 47
IS 1
BP 3500
EP 3510
DI 10.1080/21691401.2019.1652626
PG 11
WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Materials
   Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering; Materials Science
GA IS3OE
UT WOS:000482062000002
PM 31432697
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wei, YC
   Hong, HM
   Zhang, XQ
   Lai, WF
   Wang, YZ
   Chu, KD
   Brown, J
   Hong, GZ
   Chen, LD
AF Wei, Yicong
   Hong, Haimian
   Zhang, Xiaoqin
   Lai, Wenfang
   Wang, Yingzheng
   Chu, Kedan
   Brown, John
   Hong, Guizhu
   Chen, Lidian
TI Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After
   Focal Cerebral Ischemia in Rats
SO INFLAMMATION
LA English
DT Article
DE cerebral ischemia; hypoxia-inducible factors; inflammation;
   phosphoinositide 3-kinase; salidroside
ID HYPOXIA-INDUCIBLE FACTOR-1; BLOOD-BRAIN-BARRIER; ARTERY OCCLUSION;
   EXPERIMENTAL STROKE; ALZHEIMERS-DISEASE; EXPRESSION; PATHWAY;
   HIF-1-ALPHA; CELLS; ERYTHROPOIETIN
AB Salidroside is being investigated for its therapeutic potential in stroke because it is neuroprotective over an extended therapeutic window of time. In the present study, we investigated the mechanisms underlying the anti-inflammatory effects of salidroside (50 mg/kg intraperitoneally) in rats, given 1 h after reperfusion of a middle cerebral artery that had been occluded for 2 h. After 24 h, we found that salidroside increased the neuronal nuclear protein NeuN and reduced the marker of microglia and macrophages CD11b in the peri-infarct area of the brain. Salidroside also decreased IL-6, IL-1 beta, TNF-alpha, CD14, CD44, and iNOs mRNAs. At the same time, salidroside increased the ratio of phosphorylated protein kinase B (p-Akt) to total Akt. The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 prevented this increase in p-Akt and reversed the inhibitory effects of salidroside on CD11b and inflammatory mediators. Salidroside also elevated the protein levels of hypoxia-inducible factor (HIF) subunits HIF1 alpha, HIF2 alpha, HIF3 alpha, and of erythropoietin (EPO). The stimulatory effects of salidroside on HIF alpha subunits were blocked by LY294002. Moreover, YC-1, a HIF inhibitor, abolished salidroside-mediated increase of HIF1 alpha and prevented the inhibitory effects of salidroside on CD11b and inflammatory mediators. Taken together, our results provide evidence for the first time that all three HIF alpha subunits and EPO can be regulated by PI3K/Akt in cerebral tissue, and that salidroside entrains this signaling pathway to induce production of HIF alpha subunits and EPO, one or more of which mediate the anti-inflammatory effects of salidroside after cerebral IRI.
C1 [Wei, Yicong; Hong, Haimian; Zhang, Xiaoqin; Lai, Wenfang; Wang, Yingzheng; Chu, Kedan; Brown, John; Hong, Guizhu; Chen, Lidian] Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Peoples R China.
EM cbr@fjtcm.edu.cn
RI Chen, Lidian/GSN-6461-2022
OI Chen, Lidian/0000-0002-8699-0839
FU National Natural Science Foundation of China [81473382]; Department of
   Technology and Science; Department of Health of Fujian Provincial
   Government [2014Y4004, WZZY201305]; Collaborative Innovation Center for
   Rehabilitation Technology of Fujian University of TCM; TCM
   Rehabilitation Research Center of SATCM
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81473382), the Department of Technology and Science and
   the Department of Health of Fujian Provincial Government (Grant Nos.
   2014Y4004 and WZZY201305), the Collaborative Innovation Center for
   Rehabilitation Technology of Fujian University of TCM, and the TCM
   Rehabilitation Research Center of SATCM. The authors would like to
   acknowledge the staff of the Animal Centre of the Fujian University of
   TCM for their excellent technical support.
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NR 53
TC 99
Z9 118
U1 2
U2 42
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD AUG
PY 2017
VL 40
IS 4
BP 1297
EP 1309
DI 10.1007/s10753-017-0573-x
PG 13
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA EZ4DL
UT WOS:000404661800018
PM 28478514
DA 2026-05-27
ER

PT J
AU Hu, CY
   Zhang, QY
   Chen, JH
   Wen, B
   Hang, WJ
   Xu, K
   Chen, J
   He, BH
AF Hu, Cai-ying
   Zhang, Qian-ying
   Chen, Jie-hui
   Wen, Bin
   Hang, Wei-jian
   Xu, Kai
   Chen, Juan
   He, Ben-hong
TI Protective Effect of Salidroside on Mitochondrial Disturbances via
   Reducing Mitophagy and Preserving Mitochondrial Morphology in
   OGD-induced Neuronal Injury
SO CURRENT MEDICAL SCIENCE
LA English
DT Article
DE salidroside; mitochondria quality control; oxygen-glucose deprivation;
   mTOR
ID FOCAL CEREBRAL-ISCHEMIA; AUTOPHAGY; RESISTANCE; DISEASES; HYPOXIA;
   PATHWAY; STRESS; DRP1
AB Salidroside is the active ingredient extracted from Rhodiola rosea, and has been reported to show protective effects in cerebral ischemia, but the exact mechanisms of neuronal protective effects are still unrevealed. In this study, the protective effects of salidroside (1 mu mol/L) in ameliorating neuronal injuries induced by oxygen-glucose deprivation (OGD), which is a classical model of cerebral ischemia, were clarified. The results showed that after 8 h of OGD, the mouse hippocampal neuronal cell line HT22 cells showed increased cell death, accompanied with mitochondrial fragmentation and augmented mitophagy. However, the cell viability of HT22 cells showed significant restoration after salidroside treatment. Mitochondrial morphology and mitochondrial function were effectively preserved by salidroside treatment. The protective effects of salidroside were further related to the prevention of mitochondrial over-fission. The results showed that mTOR could be recruited to the mitochondria after salidroside treatment, which might be responsible for inhibiting excessive mitophagy caused by OGD. Thus, salidroside was shown to play a protective role in reducing neuronal death under OGD by safeguarding mitochondrial function, which may provide evidence for further translational studies of salidroside in ischemic diseases.
C1 [Hu, Cai-ying] Wuhan Red Cross Hosp, Dept Cardiol, Wuhan 430015, Peoples R China.
   [Zhang, Qian-ying; Chen, Jie-hui; Wen, Bin; Hang, Wei-jian; Xu, Kai; Chen, Juan] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Biochem & Mol Biol, Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Zhang, Qian-ying] Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Dept Clin Lab, Wuhan 430030, Peoples R China.
   [Hang, Wei-jian] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Cardiol,Dept Internal Med, Wuhan 430030, Peoples R China.
   [Hang, Wei-jian] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan 430030, Peoples R China.
   [He, Ben-hong] Lichuan Peoples Hosp, Dept Cardiovasc Med, Lichuan 445400, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology
RP Chen, J (corresponding author), Huazhong Univ Sci & Technol, Sch Basic Med, Dept Biochem & Mol Biol, Tongji Med Coll, Wuhan 430030, Peoples R China.; He, BH (corresponding author), Lichuan Peoples Hosp, Dept Cardiovasc Med, Lichuan 445400, Peoples R China.
EM 841985741@qq.com; 506844936@qq.com; chenjuanlinda69@163.com;
   lczyyhbh@163.com
CR Ba L, 2019, PHYTOMEDICINE, V58, DOI 10.1016/j.phymed.2018.11.025
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NR 35
TC 19
Z9 20
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2096-5230
EI 2523-899X
J9 CURR MED SCI
JI Curr. Med. Sci.
PD OCT
PY 2021
VL 41
IS 5
BP 936
EP 943
DI 10.1007/s11596-021-2374-6
EA JUN 2021
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WL5HH
UT WOS:000667594000002
PM 34181207
DA 2026-05-27
ER

PT J
AU Leung, SB
   Zhang, HN
   Lau, CW
   Huang, Y
   Lin, ZX
AF Leung, Sin Bond
   Zhang, Huina
   Lau, Chi Wai
   Huang, Yu
   Lin, Zhixiu
TI Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by
   Reducing Oxidative Stress
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DEPENDENT RELAXATION; NITRIC-OXIDE; ATHEROSCLEROSIS; PATHOGENESIS;
   APOPTOSIS; MECHANISM; INJURY; RISK
AB Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases through increased oxidative stress. Salidroside is an active ingredient of the root of Rhodiola rosea with documented antioxidative, antihypoxia and neuroprotective properties. However, the vascular benefits of salidroside against endothelial dysfunction have yet to be explored. The present study, therefore, aimed to investigate the protective effect of salidroside on homocysteine-induced endothelial dysfunction. Functional studies on the rat aortas were performed to delineate the vascular effect of salidroside. DHE imaging was used to evaluate the reactive oxygen species (ROS) level in aortic wall and endothelial cells. Western blotting was performed to assess the protein expression associated with oxidative stress and nitric oxide (NO) bioavailability. Exposure to homocysteine attenuated endothelium-dependent relaxations in rat aortas while salidroside pretreatment rescued it. Salidroside inhibited homocystein-induced elevation in the NOX2 expression and ROS overproduction in both aortas and cultured endothelial cells and increased phosphorylation of eNOS which was diminished by homocysteine. The present study shows that salidroside is effective in preserving the NO bioavailability and thus protects against homocysteine-induced impairment of endothelium-dependent relaxations, largely through inhibiting the NOX2 expression and ROS production. Our results indicate a therapeutic potential of salidroside in the management of oxidative-stress-associated cardiovascular dysfunction.
C1 [Leung, Sin Bond; Lin, Zhixiu] Chinese Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China.
   [Zhang, Huina; Lau, Chi Wai; Huang, Yu] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China.
   [Zhang, Huina; Lau, Chi Wai; Huang, Yu] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Huang, Y (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China.
EM yu-huang@cuhk.edu.hk; b107584@mailserv.cuhk.edu.hk
RI Huang, Yu/K-2866-2017; Lin, Zhi-Xiu/H-2807-2016
OI Huang, Yu/0000-0002-1277-6784; 
FU CUHK [2030434]; CUHK Focused Investment Scheme B
FX This study was partly supported by a CUHK Direct Grant (Project no.
   2030434) and CUHK Focused Investment Scheme B.
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NR 24
TC 36
Z9 40
U1 2
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 679635
DI 10.1155/2013/679635
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 121IJ
UT WOS:000317236300001
PM 23589720
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, P
   Li, WJ
   Wang, L
   Liu, HJ
   Gong, J
   Wang, F
   Chen, XP
AF Zhang, Peng
   Li, Wenjiong
   Wang, Lu
   Liu, Hongju
   Gong, Jing
   Wang, Fei
   Chen, Xiaoping
TI Salidroside Inhibits Myogenesis by Modulating p-Smad3-Induced Myf5
   Transcription
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; myogenesis; Myf5; p-Smad3; myoblast; reserve cell
ID MUSCLE STEM-CELLS; ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR-BETA;
   LOW-DOSE REGIMEN; SKELETAL-MUSCLE; RHODIOLA-ROSEA; OXIDATIVE STRESS;
   SIGNALING PATHWAY; SATELLITE CELLS; DOUBLE-BLIND
AB Aim: Salidroside is an active compound extracted from Rhodiola rosea which is used to alleviate fatigue and enhance endurance in high altitude regions. Some studies have demonstrated that salidroside can affect precursor cell differentiation in hematopoietic stem cells, erythrocytes, and osteoblasts. The aim of this study was to investigate the effect of salidroside on myoblast differentiation and to explore the underlying molecular mechanisms of this effect.
   Methods: C2C12 myoblast cells were treated with different concentrations of salidroside in differentiation media. Real-time PCR, Western blotting, and immunofluorescence assay were employed to evaluate the effects of salidroside on C2C12 differentiation. RNA interference was used to reveal the important role of Myf5 in myogenesis inhibited by salidroside. Chromatin Immunoprecipitation and dual-luciferase reporter assay were utilized to explore the underlying mechanisms of salidroside-induced upregulation of Myf5.
   Results: We found that salidroside inhibits myogenesis by downregulating MyoD and myogenin, preserves undifferentiated reserve cell pools by upregulating Myf5. Knocking down Myf5 expression significantly rescued the myogenesis inhibited by salidroside. The effect of salidroside on myogenesis was associated with increased phosphorylated Smad3 (p-Smad3). Both SIS3 (Specific inhibitor of p-Smad3) and dominant negative Smad3 plasmid (DN-Smad3) attenuated the inhibitory effect of salidroside on C2C12 differentiation. Moreover, the induction of Myf5 transcription by salidroside was dependent on a Smad-binding site in the promoter region of Myf5 gene.
   Conclusion and Implications: Our findings identify a novel role and mechanism for salidroside in regulating myogenesis through p-Smad3-induced Myf5 transcription, which may have implications for its further application in combating degenerative muscular diseases caused by depletion of muscle stem cells, such as Duchenne muscular dystrophy or sarcopenia.
C1 [Zhang, Peng; Li, Wenjiong; Liu, Hongju; Chen, Xiaoping] China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing, Peoples R China.
   [Wang, Lu; Gong, Jing; Wang, Fei; Chen, Xiaoping] China Astronaut Res & Training Ctr, Natl Key Lab Human Factors Engn, Beijing, Peoples R China.
C3 Chinese Academy of Sciences
RP Chen, XP (corresponding author), China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing, Peoples R China.; Chen, XP (corresponding author), China Astronaut Res & Training Ctr, Natl Key Lab Human Factors Engn, Beijing, Peoples R China.
EM xpchen2009@163.com
FU National Natural Science Foundation of China [81401765, 81772016,
   11727813, 81272177]; 1226 Major Project [AWS16J018]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81401765 to PZ; 81772016, 11727813, and 81272177 to
   XC) and the 1226 Major Project (AWS16J018 to XC).
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NR 43
TC 8
Z9 11
U1 0
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 12
PY 2018
VL 9
AR 209
DI 10.3389/fphar.2018.00209
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FY9DD
UT WOS:000427164700001
PM 29593538
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hao, WW
   Li, N
   Mi, CF
   Wang, Q
   Yu, YY
AF Hao, Weiwei
   Li, Na
   Mi, Caifeng
   Wang, Qiang
   Yu, Yuanyuan
TI Salidroside attenuates cardiac dysfunction in a rat model of diabetes
SO DIABETIC MEDICINE
LA English
DT Article
DE diabetes; heart failure; oxidative stress; salidroside
ID MYOCARDIAL INJURY; OXIDATIVE STRESS; IN-VITRO; CARDIOMYOPATHY;
   APOPTOSIS; INFLAMMATION; INHIBITORS; METFORMIN; DPP-4
AB Aim This study aimed to investigate the therapeutic effects of salidroside on diabetes-induced cardiovascular disease. Methods Sprague-Dawley rats treated with 65 mg/kg of streptozotocin (STZ) on a daily basis were used to establish the diabetic rat model (blood glucose levels >13.9 mmol/L). Cardiac functions of diabetic rats were evaluated by their haemodynamic alterations. Western blot assay was performed to evaluate the protein levels of multiple signalling pathway factors. Quantitative real-time PCR assay was performed to investigate the inflammation and oxidative stress of diabetic rats. Results Salidroside treatment improved the cardiac functions of diabetic rats. In addition, salidroside therapy attenuated the cardiac oxidative stress induced by diabetes. Salidroside inhibited the diabetes-induced inflammation in diabetic rat hearts. The apoptosis of cardiomyocytes was also alleviated by the treatment of salidroside. Salidroside also upregulated the phosphorylation levels of AMPK, ACC, TSC2 and RAPTOR. Conclusion Salidroside exerts protective effects against diabetes-induced cardiac dysfunction by modulating the mTOR and AMPK signalling pathways.
C1 [Hao, Weiwei; Li, Na] Pingdingshan Univ, Coll Med, Dept Clin Med, 2 Chongwen Rd, Pingdingshan 467000, Henan, Peoples R China.
   [Mi, Caifeng] Pingdingshan Univ, Dept Gastroenterol, Affiliated Hosp 1, Pingdingshan, Henan, Peoples R China.
   [Wang, Qiang] Pingdingshan Univ, Dept Cardiol, Affiliated Hosp 1, Pingdingshan, Henan, Peoples R China.
   [Yu, Yuanyuan] Pingdingshan Univ, Dept Endocrinol, Affiliated Hosp 1, Pingdingshan, Henan, Peoples R China.
C3 Pingdingshan University; Pingdingshan University; Pingdingshan
   University; Pingdingshan University
RP Hao, WW (corresponding author), Pingdingshan Univ, Coll Med, Dept Clin Med, 2 Chongwen Rd, Pingdingshan 467000, Henan, Peoples R China.
EM haoweizz@163.com
RI Li, Wei/HOH-0479-2023; Yu, Yuanyuan/ODM-4530-2025
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NR 41
TC 10
Z9 14
U1 2
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAR
PY 2022
VL 39
IS 3
AR e14683
DI 10.1111/dme.14683
EA SEP 2021
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YY5TT
UT WOS:000696036000001
PM 34467560
DA 2026-05-27
ER

PT J
AU Yang, YH
   Cao, YM
   Zhu, CR
   Jin, Y
   Sun, HW
   Wang, R
   Li, MJ
   Zhang, ZY
AF Yang, Yanhui
   Cao, Yiming
   Zhu, Changrui
   Jin, Yan
   Sun, Huiwen
   Wang, Rong
   Li, Mingjie
   Zhang, Zhongyi
TI Functional activities of three Rehmannia glutinosa
   enzymes: Elucidation of the Rehmannia glutinosa
   salidroside biosynthesis pathway in Saccharomyces cerevisiae
SO GENE
LA English
DT Article
DE Phenylethanoid glycoside; Salidroside biosynthesis pathway; Catalytic
   enzyme; Functional activity; Heterologous expression
ID MULTIGENE FAMILY; AMINE OXIDASE; ALCOHOL-DEHYDROGENASE; PLANT;
   GLYCOSYLTRANSFERASES; EXPRESSION; ROOTS; GENES; STEP
AB Rehmannia glutinosa produces many phenylethanoid glycoside (PhG) compounds, including salidroside, which not only possesses various biological activities but also is a core precursor of some medicinal PhGs, so it is very important to elucidate the species' salidroside biosynthesis pathway to enhance the production of salidroside and its derivations. Although some plant copper-containing amine oxidases (CuAOs), phenylacetaldehyde reductases (PARs) and UDP-glucose glucosyltransferases (UGTs) are thought to be vital catalytic enzymes involved in the downstream salidroside biosynthesis pathways, to date, none of these proteins or the associated genes in R. glutinosa have been characterized. To verify a postulated R. glutinosa salidroside biosynthetic pathway starting from tyrosine, this study identified and characterized a set of R. glutinosa genes encoding RgCuAO, RgPAR and RgUGT enzymes for salidroside biosynthesis. The functional activities of these proteins were tested in vitro by heterologous expression of these genes in Escherichia coli, confirming these catalytic abilities in these corresponding reaction steps of the biosynthetic pathway. Importantly, four enzyme-encoding genes (including the previously reported RgTyDC2 encoding tyrosine decarboxylase and the RgCuAO1, RgPAR1 and RgUGT2 genes) were cointegrated into Saccharomyces cerevisiae to reconstitute the R. glutinosa salidroside biosynthetic pathway, achieving an engineered strain that produced salidroside and validating these enzymes' catalytic functions. This study elucidates the complete R. glutinosa salidroside biosynthesis pathway from tyrosine metabolism in S. cerevisiae, establishing a basic platform for the efficient production of salidroside and its derivatives.
C1 [Yang, Yanhui; Cao, Yiming; Zhu, Changrui; Jin, Yan; Sun, Huiwen; Wang, Rong] Henan Univ Technol, Sch Bioengn, Lianhua St 100, Zhengzhou 450001, Henan Province, Peoples R China.
   [Li, Mingjie; Zhang, Zhongyi] Fujian Agr & Forestry Univ, Coll Crop Sci, Jinshan Rd, Fuzhou 350002, Peoples R China.
C3 Henan University of Technology; Fujian Agriculture & Forestry University
RP Yang, YH (corresponding author), Henan Univ Technol, Sch Bioengn, Lianhua St 100, Zhengzhou 450001, Henan Province, Peoples R China.
EM yyhui2004@haut.edu.cn
OI , Yanhui/0000-0003-3896-916X; Sun, Huiwen/0009-0000-5311-785X
FU National Natural Science Foundation of China [82274049, 82073965,
   81973417]; Key Research and Development Special Project of Henan
   Province [242102311169]
FX Funding This research was supported by grants from the National
   Natural Science Foundation of China (No. 82274049, 82073965 and
   81973417) and the Key Research and Development Special Project of Henan
   Province (No. 242102311169) .
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TC 3
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U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD NOV 30
PY 2024
VL 928
AR 148815
DI 10.1016/j.gene.2024.148815
EA AUG 2024
PG 13
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA C3G8Q
UT WOS:001288278100001
PM 39097208
DA 2026-05-27
ER

PT J
AU Lv, C
   Huang, Y
   Liu, ZX
   Yu, D
   Bai, ZM
AF Lv, Cai
   Huang, Yuan
   Liu, Zhen-Xiang
   Yu, Dan
   Bai, Zhi-Ming
TI Salidroside reduces renal cell carcinoma proliferation by inhibiting
   JAK2/STAT3 signaling
SO CANCER BIOMARKERS
LA English
DT Article
DE Salidroside; renal cell carcinoma; growth; JAK2/STAT3; apoptosis
ID RHODIOLA-ROSEA-L.; CANCER STATISTICS; MELANOMA-CELLS; KIDNEY CANCER;
   PATHWAY; APOPTOSIS; ACTIVATION; MICE; RESPONSES; OBESITY
AB Salidroside has been reported to exhibit anticancer properties. This study aimed to investigate the effects of salidroside on renal cell carcinoma growth. Cell viability and proliferation was assessed by Cell Counting Kit-8 and colony formation assays in A498 and 786-0 cells. The effects of salidroside on in vivo tumor growth were also assessed in a mouse xenograft model of renal cell carcinoma. Flow cytometry was used to analyze cell cycle and apoptosis and protein levels were determined by western blotting. Salidroside reduced cell viability and colony formation in both cell lines in a concentration- and time-dependent manner. Tumor growth was also suppressed in the mouse model. Furthermore, salidroside induced significant G1 phase cell cycle arrest and induced apoptosis in both A498 and 786-0 cells. Higher concentrations of salidroside reduced the levels of phosphorylated signal transducer and activator of transcription 3 (STAT3) and Janus kinase 2 (JAK2). These results suggested that salidroside produced potent anticancer properties in renal cell carcinoma by modulating JAK2/STAT3 signaling. Administration of salidroside to patients with renal cell carcinoma might provide a promising therapeutic strategy for this malignancy.
C1 [Lv, Cai; Liu, Zhen-Xiang; Bai, Zhi-Ming] Haikou Municipal Hosp, Dept Urol, Haikou 570208, Hainan, Peoples R China.
   [Huang, Yuan; Yu, Dan] Haikou Municipal Hosp, Dept Neurol, Haikou, Hainan, Peoples R China.
RP Bai, ZM (corresponding author), Haikou Municipal Hosp, Dept Urol, Haikou 570208, Hainan, Peoples R China.
EM Hkbzm59@aliyun.com
FU Natural Science Foundation of Hainan Province [20158264]
FX The study was supported by Natural Science Foundation of Hainan Province
   (No. 20158264).
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NR 37
TC 47
Z9 57
U1 0
U2 23
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1574-0153
EI 1875-8592
J9 CANCER BIOMARK
JI Cancer Biomark.
PY 2016
VL 17
IS 1
BP 41
EP 47
DI 10.3233/CBM-160615
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DS9OZ
UT WOS:000381114300006
PM 27314291
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zheng, XT
   Wu, ZH
   Wei, Y
   Dai, JJ
   Yu, GF
   Yuan, FL
   Ye, LC
AF Zheng, Xiang-Tao
   Wu, Zi-Heng
   Wei, Ye
   Dai, Ju-Ji
   Yu, Guan-Feng
   Yuan, FengLai
   Ye, Le-Chi
TI Induction of autophagy by salidroside through the AMPK-mTOR pathway
   protects vascular endothelial cells from oxidative stress-induced
   apoptosis
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Autophagy; Salidroside; Vascular endothelial cells; Oxidative stress;
   Signaling pathway
ID PEROXIDE-INDUCED INJURY; NF-KAPPA-B; ISCHEMIA/REPERFUSION INJURY;
   DYSFUNCTION; DEATH; INHIBITION; DEFICIENCY; BIOLOGY; LIFE
AB Vascular endothelial cells are highly sensitive to oxidative stress, and this is one of the mechanisms by which widespread endothelial dysfunction is induced in most cardiovascular diseases and disorders. However, how these cells can survive in oxidative stress environments remains unclear. Salidroside, a traditional Chinese medicine, has been shown to confer vascular protective effects. We aimed to understand the role of autophagy and its regulatory mechanisms by treating human umbilical vein endothelial cells (HUVECs) with salidroside under oxidative stress. HUVECs were treated with salidroside and exposed to hydrogen peroxide (H2O2). The results indicated that salidroside exerted cytoprotective effects in an H2O2-induced HUVEC injury model and suppressed H2O2-induced apoptosis of HUVECs. Pretreatment with 3-methyladenine (3-MA), an autophagy inhibitor, increased oxidative stress-induced HUVEC apoptosis, while the autophagy activator rapamycin induced anti-apoptosis effects in HUVECs. Salidroside increased autophagy and decreased apoptosis of HUVECs in a dose-dependent manner under oxidative stress. Moreover, 3-MA attenuated salidroside-induced HUVEC autophagy and promoted apoptosis, whereas rapamycin had no additional effects compared with salidroside alone. Salidroside upregulated AMPK phosphorylation but downregulated mTOR phosphorylation under oxidative stress; however, administration of compound C, an AMPK inhibitor, abrogated AMPK phosphorylation and increased mTOR phosphorylation and apoptosis compared with salidroside alone. These results suggest that autophagy is a protective mechanism in HUVECs under oxidative stress and that salidroside might promote autophagy through activation of the AMPK pathway and downregulation of mTOR pathway.
C1 [Zheng, Xiang-Tao; Dai, Ju-Ji; Yu, Guan-Feng] Wenzhou Med Univ, Dept Vasc Surg, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Wu, Zi-Heng] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Vasc Surg, Hangzhou, Zhejiang, Peoples R China.
   [Wei, Ye] Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai, Peoples R China.
   [Yuan, FengLai] Nantong Univ, Dept Cent Lab, Hosp 3, Wuxi 214041, Jiangsu, Peoples R China.
   [Ye, Le-Chi] Wenzhou Med Univ, Dept Surg Oncol, Affiliated Hosp 1, Wenzhou 325015, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Zhejiang University; Fudan University;
   Nantong University; Wenzhou Medical University
RP Yuan, FL (corresponding author), Nantong Univ, Dept Cent Lab, Hosp 3, Wuxi 214041, Jiangsu, Peoples R China.; Ye, LC (corresponding author), Wenzhou Med Univ, Dept Surg Oncol, Affiliated Hosp 1, Wenzhou 325015, Zhejiang, Peoples R China.
EM wangyu3h@163.com; yljwenzhou@126.com
RI Wu, Ziheng/KMA-1138-2024
FU Natural Science Foundation of China [81270011, 81472125]; Zhejiang
   Provincial Natural Science Foundation of China [LY15H160058]; Zhejiang
   Provincial Medical technology science [2015KYB245]
FX This work was supported by the Natural Science Foundation of China
   (81270011; 81472125). Zhejiang Provincial Natural Science Foundation of
   China under Grant (No. LY15H160058); Zhejiang Provincial Medical
   technology science project (No. 2015KYB245).
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NR 47
TC 62
Z9 69
U1 0
U2 50
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2017
VL 425
IS 1-2
BP 125
EP 138
DI 10.1007/s11010-016-2868-x
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EI3OE
UT WOS:000392399700012
PM 27848074
DA 2026-05-27
ER

PT J
AU Xu, MC
   Shi, HM
   Wang, H
   Gao, XF
AF Xu, Mao-Chun
   Shi, Hai-Ming
   Wang, Hao
   Gao, Xiu-Fang
TI Salidroside protects against hydrogen peroxide-induced injury in HUVECs
   via the regulation of REDD1 and mTOR activation
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; oxidative injury; REDD1; mTOR; apoptosis; signal
   transduction
ID CARDIAC H9C2 CELLS; OXIDATIVE STRESS; ENERGY STRESS; RAPAMYCIN; HYPOXIA;
   GROWTH; APOPTOSIS; PATHWAY; TARGET; HEART
AB Antioxidative therapy is considered an effective strategy for treating oxidative stress-induced apoptosis in cardiovascular diseases. Salidroside has been used as an antioxidative therapy for oxidative injury in cardiac diseases. However, the mechanism underlying its antioxidant effect is poorly understood. The present study aimed to investigate the pharmacological effects of salidroside on cultured human umbilical vein endothelial cells (HUVECs) under conditions of oxidative injury induced by hydrogen peroxide (H2O2) and the underlying mechanisms in vitro. HUVECs pretreated with or without salidroside for 24 h were exposed to H2O2-induced oxidative stress conditions for 6 h and then cell viability, apoptosis, HIF-1 alpha, regulated in development and DNA damage responses-1 (REDD1) and the PI3K/Akt/mTOR pathway were investigated. The results demonstrated that salidroside effectively attenuated H2O2-impaired cell viability and the production of reactive oxygen species (ROS) in a concentration-dependent manner. Reduced H2O2-induced apoptosis and activation of the cellular PI3K/Akt/mTOR pathway were demonstrated in HUVECs pretreated with salidroside. Furthermore, the level of REDD1, a direct regulator of mitochondrial metabolism, significantly increased in parallel with the level of HIF-1 alpha following pretreatment with salidroside. The antioxidative effect of salidroside was abrogated in REDD1 knockdown cells. However, LY294002, a PI3K inhibitor, attenuated the anti-apoptotic effect of salidroside and blocked the increase of Akt and mTOR; however, did not affect the antioxidative effect of salidroside. These findings suggested that salidroside was capable of protecting HUVECs against H2O2-induced apoptosis by activating the PI3K/Akt/mTOR-dependent pathway and inhibiting ROS production by activating REDD1.
C1 [Xu, Mao-Chun; Shi, Hai-Ming; Gao, Xiu-Fang] Fudan Univ, Huashan Hosp, Dept Cardiol, Shanghai 200040, Peoples R China.
   [Wang, Hao] Fudan Univ, Shanghai Med Sch, Minist Educ, Key Lab Mol Med, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University
RP Gao, XF (corresponding author), Fudan Univ, Huashan Hosp, Dept Cardiol, 12 Urumuqi Rd, Shanghai 200040, Peoples R China.
EM sophiakao@126.com
FU Natural Science Foundation of China [81001561]
FX This study was financially supported by the funding of the Natural
   Science Foundation of China (no. 81001561).
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NR 27
TC 40
Z9 47
U1 0
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2013
VL 8
IS 1
BP 147
EP 153
DI 10.3892/mmr.2013.1468
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 173KV
UT WOS:000321079300023
PM 23660824
OA Bronze
DA 2026-05-27
ER

PT J
AU Lan, KC
   Chao, SC
   Wu, HY
   Chiang, CL
   Wang, CC
   Liu, SH
   Weng, TI
AF Lan, Kuo-Cheng
   Chao, Sung-Chuan
   Wu, Hsiao-Yi
   Chiang, Chia-Lien
   Wang, Ching-Chia
   Liu, Shing-Hwa
   Weng, Te-I.
TI Salidroside ameliorates sepsis-induced acute lung injury and mortality
   via downregulating NF-κB and HMGB1 pathways through the
   upregulation of SIRT1
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BOX 1; INFLAMMATION; INHIBITION; LIPOPOLYSACCHARIDE; APOPTOSIS;
   SURVIVAL; TARGET; MODEL; MICE
AB Sepsis is a life-threatening medical condition. Salidroside, a substance isolated from Rhodiola rosea, possesses antioxidant and anti-inflammatory properties. The effect and mechanism of salidroside on sepsis-induced acute lung injury still remains to be well clarified. Here, we investigated the effect and mechanism of salidroside on septic mouse models and explored the role of salidroside-upregulated SIRT1. Salidroside inhibited the inflammatory responses and HMGB1 productions in bacterial lipopolysaccharide (LPS)-treated macrophages and mice. Salidroside could also reverse the decreased SIRT1 protein expression in LPS-treated macrophages and mice. Salidroside also alleviated the sepsis-induced lung edema, lipid peroxidation, and histopathological changes and the mortality, and improved the lung PaO2/FiO(2) ratio in cecal ligation and puncture (CLP)-induced septic mice. Salidroside significantly decreased the serum TNF-alpha, IL-6, NO, and HMGB1 productions, pulmonary inducible NO synthase (iNOS) and phosphorylated NF-kappa B-p65 protein expressions, and pulmonary HMGB1 nuclear translocation in CLP septic mice. Moreover, sepsis decreased the SIRT1 protein expression in the lungs of CLP septic mice. Salidroside significantly upregulated the SIRT1 expression and inhibited the inflammatory responses in CLP septic mouse lungs. These results suggest that salidroside protects against sepsis-induced acute lung injury and mortality, which might be through the SIRT1-mediated repression of NF-kappa B activation and HMGB1 nucleocytoplasmic translocation.
C1 [Lan, Kuo-Cheng] Natl Def Med Ctr, Triserv Gen Hosp, Dept Emergency Med, Taipei, Taiwan.
   [Chao, Sung-Chuan] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Surg, Hsinchu, Taiwan.
   [Wu, Hsiao-Yi; Chiang, Chia-Lien; Weng, Te-I.] Natl Taiwan Univ, Coll Med, Dept Forens Med, Taipei, Taiwan.
   [Wang, Ching-Chia; Liu, Shing-Hwa] Natl Taiwan Univ Hosp, Dept Pediat, Taipei, Taiwan.
   [Liu, Shing-Hwa] Natl Taiwan Univ, Coll Med, Inst Toxicol, Taipei, Taiwan.
   [Weng, Te-I.] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, Taiwan.
C3 National Defense Medical University; Tri-Service General Hospital;
   National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital
RP Weng, TI (corresponding author), Natl Taiwan Univ, Coll Med, Dept Forens Med, Taipei, Taiwan.; Weng, TI (corresponding author), Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, Taiwan.
EM wengtei2@ntu.edu.tw
OI WANG, CHING-CHIA/0000-0002-5954-5684; Weng, Te-I/0000-0002-8797-1672;
   LIU, SHING-HWA/0000-0002-9976-1197; Chao, Sung-Chuan/0000-0002-5758-0494
FU Ministry of Science and Technology of Taiwan [103-2320-B-002-007-MY2,
   105-2320-B-002-017]
FX This study was supported by a research grant from the Ministry of
   Science and Technology of Taiwan (103-2320-B-002-007-MY2,
   105-2320-B-002-017).
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NR 41
TC 99
Z9 112
U1 1
U2 24
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 20
PY 2017
VL 7
AR 12026
DI 10.1038/s41598-017-12285-8
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FH5DV
UT WOS:000411185100079
PM 28931916
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, J
   Yin, T
   Xiao, H
   Gao, P
   Si, LY
AF Wu, Jie
   Yin, Tao
   Xiao, Hang
   Gao, Pan
   Si, Liangyi
TI Salidroside reduce inflammatory cytokines in atherosclecrosis via
   suppressing MAPK and NF-κB signaling pathway
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Salidroside; atherosclerosis; MAPK; NF-kappa B
ID CORONARY-ARTERY-DISEASE; AMERICAN-HEART-ASSOCIATION; ADHESION MOLECULES;
   ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS; IN-VITRO; ATHEROSCLEROSIS;
   ACTIVATION; EXPRESSION; PATHOPHYSIOLOGY
AB Objective: Atherosclerosis is a kind of cardiovascular disease with very high mortality. Recent studies found that inflammatory response in the cardiovascular system accelerated atherosclerosis. The effect and underlying mechanism of salidroside on atherosclerosis remains unclear. The aim of our study was to investigate possible mechanism of salidroside on atherosclerosis. Methods: 60 ApoE-/-mice were divided into four groups: normal diet group (NDG), high fat diet group (HFDG), HFDG with 20 mg/kg/day of salidroside and HFDG with 40 mg/kg/day of salidroside. Weight of the mice was measured through the whole study. ELISA was used to detect the inflammatory factors in the mice serum to evaluate the effect of salidroside on the expression of inflammatory cytokines. Western Blot was used to detect the activation of MAPK and NF-kappa B signaling pathway, as well as the expression of eNOS and NRF2, in the aorta of ApoE-/-mice. The phosphorylation of p38 and p65 were also detected by Western Blot. Results: Compared with the HFDG, the level of inflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6) were decreased after the treatment of 20 mg/kg and 40 mg/kg salidroside, in a dose-dependent manner. What's more, phosphorylation of p38 and p65 were increased in HFDG while they were suppressed in the group treated with salidroside. We also found that the expression of eNOS and NRF2 were increased after the treatment of salidroside. Conclusion: Salidroside could inhibit the inflammatory responses induced by HFD in the ApoE-/-mice. Salidroside may reduce the expression of inflammatory cytokines by suppressing MAPK and NF-kappa B signaling pathway.
C1 [Wu, Jie; Xiao, Hang; Gao, Pan; Si, Liangyi] Third Mil Med Univ, Affiliated Hosp 1, Dept Geriatr, Chongqing 400038, Peoples R China.
   [Yin, Tao] Chongqing Med Univ, Dept Tradit Chinese Med, Chongqing 401331, Peoples R China.
C3 Army Medical University; Chongqing Medical University
RP Si, LY (corresponding author), Third Mil Med Univ, Affiliated Hosp 1, Dept Geriatr, Chongqing 400038, Peoples R China.
EM Dr_liangyisi@yeah.net
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NR 39
TC 1
Z9 2
U1 0
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 4
BP 3533
EP 3541
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GE6JV
UT WOS:000431333500062
DA 2026-05-27
ER

PT J
AU Yin, WY
   Ye, Q
   Huang, HJ
   Xia, NG
   Chen, YY
   Zhang, Y
   Qu, QM
AF Yin, Wei-Yong
   Ye, Qiang
   Huang, Huan-Jie
   Xia, Nian-Ge
   Chen, Yan-Yan
   Zhang, Yi
   Qu, Qiu-Min
TI Salidroside protects cortical neurons against glutamate-induced
   cytotoxicity by inhibiting autophagy
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Salidroside; Cortical neurons; Cytotoxicity; Autophagy; Neuronal injury
ID FOCAL CEREBRAL-ISCHEMIA; CELL-DEATH; MOLECULAR-MECHANISMS;
   UP-REGULATION; ACTIVATION; P53; RAT; 3-METHYLADENINE; CONTRIBUTES;
   APOPTOSIS
AB Recent evidence suggests that glutamate-induced cytotoxicity contributes to autophagic neuron death and is partially mediated by increased oxidative stress. Salidroside has been demonstrated to have neuroprotective effects in glutamate-induced neuronal damage. The precise mechanism of its regulatory role in neuronal autophagy is, however, poorly understood. This study aimed to probe the effects and mechanisms of salidroside in glutamate-induced autophagy activation in cultured rat cortical neurons. Cell viability assay, Western blotting, coimmunoprecipitation, and small interfering RNA were performed to analyze autophagy activities during glutamate-evoked oxidative injury. We found that salidroside protected neonatal neurons from glutamate-induced apoptotic cell death. Salidroside significantly attenuated the LC3-II/LC3-I ratio and expression of Beclin-1, but increased (SQSTM1)/p62 expression under glutamate exposure. Pretreatment with 3-methyladenine (3-MA), an autophagy inhibitor, decreased LC3-II/LC3-I ratio, attenuated glutamate-induced cell injury, and mimicked some of the protective effects of salidroside against glutamate-induced cell injury. Molecular analysis demonstrated that salidroside inhibited cortical neuron autophagy in response to glutamate exposure through p53 signaling by increasing the accumulation of cytoplasmic p53. Salidroside inhibited the glutamate-induced dissociation of the Bcl-2-Beclin-1 complex with minor affects on the PI3K/Akt/mTOR signaling pathways. These data demonstrate that the inhibition of autophagy could be responsible for the neuroprotective effects of salidroside on glutamate-induced neuronal injury.
C1 [Yin, Wei-Yong; Qu, Qiu-Min] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, Xian 710061, Shanxi, Peoples R China.
   [Ye, Qiang; Huang, Huan-Jie; Xia, Nian-Ge; Chen, Yan-Yan] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Zhang, Yi] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Wenzhou Medical
   University
RP Qu, QM (corresponding author), Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, Xian 710061, Shanxi, Peoples R China.
EM qqmxian@163.com
FU 863-Chinese National Science and Technology Project [2007AA02Z443]
FX This research was supported by the 863-Chinese National Science and
   Technology Project (2007AA02Z443).
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NR 47
TC 27
Z9 29
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD AUG
PY 2016
VL 419
IS 1-2
BP 53
EP 64
DI 10.1007/s11010-016-2749-3
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DT0YI
UT WOS:000381208500006
PM 27357827
DA 2026-05-27
ER

PT J
AU Dai, ZY
   Zhang, X
   Li, WY
   Tang, JX
   Pan, TT
   Ma, CR
   Guan, QL
AF Dai, Ziying
   Zhang, Xuan
   Li, Wuyan
   Tang, Junxia
   Pan, Tingting
   Ma, Chenru
   Guan, Quanlin
TI Salidroside Induces Apoptosis in Human Gastric Cancer Cells via
   the of ENO1/PKM2/GLUT1 Expression
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE salidroside; gastric cancer; glycolysis; enolase 1 (ENO1); pyruvate
   kinase isoenzyme M2 (PKM2); glucose transporter 1 (GLUT1)
ID IN-VITRO
AB Salidroside is reported to have a wide range of pharmacological properties and has been proven to play a key anti-cancer effect. This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM2), enolase 1 (ENO1) and glucose transporter 1 (GLUT1), which could play important roles in the metabolism of gastric cancer cells. Further investigation showed that salidroside exerted potent anti proliferative effects by inhibiting glycolysis in human gastric cancer cells in vitro. In vivo, xenograft tumors treated with salidroside were significantly smaller than those in the control animals. Therefore, salidroside could be a promising therapeutic prospect in the treatment of gastric cancer.
C1 [Dai, Ziying; Tang, Junxia; Pan, Tingting; Ma, Chenru] Lanzhou Univ, Clin Med Collage 1, Lanzhou 730000, Gansu, Peoples R China.
   [Zhang, Xuan] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China.
   [Zhang, Xuan] Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Gansu, Peoples R China.
   [Li, Wuyan] Temple Univ, Sch Med, Ctr Inflammat Translat & Clin Lung Res, Philadelphia, PA 19140 USA.
   [Guan, Quanlin] Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
   [Guan, Quanlin] Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University; Gansu University of Chinese
   Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Temple University; Lanzhou University; Lanzhou University
RP Guan, QL (corresponding author), Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.; Guan, QL (corresponding author), Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.
EM guanquanlin@163.com
RI /AAH-6085-2020
FU Key Technologies Research and Development Program (CN) [2017YFC0908302]
FX The authors thank the Central laboratory of the First Hospital of
   Lanzhou University for assisting with the experiments. This study was
   supported by the Key Technologies Research and Development Program (CN)
   (2017YFC0908302).
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NR 29
TC 25
Z9 31
U1 2
U2 23
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
EI 1347-5215
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD NOV
PY 2021
VL 44
IS 11
BP 1724
EP 1731
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YF2TV
UT WOS:000741666600001
PM 34471002
OA gold
DA 2026-05-27
ER

PT J
AU Liang, KK
   Ma, SH
   Luo, K
   Wang, RJ
   Xiao, CR
   Zhang, XX
   Gao, Y
   Li, MX
AF Liang, Keke
   Ma, Shuhe
   Luo, Kai
   Wang, Renjie
   Xiao, Chenrong
   Zhang, Xianxie
   Gao, Yue
   Li, Maoxing
TI Salidroside: An Overview of Its Promising Potential and Diverse
   Applications
SO PHARMACEUTICALS
LA English
DT Review
DE salidroside; pharmacology; signaling pathways; clinical application;
   safety; review
ID NF-KAPPA-B; PARKINSONS-DISEASE; INDUCED APOPTOSIS; OXIDATIVE STRESS;
   CELLS; INFLAMMATION; ACTIVATION; PATHWAY; INJURY; TOXICITY
AB Salidroside, a phenolic compound isolated from various Rhodiola plants, is the principal active constituent of Traditional Chinese Medicine known for its adaptogenic properties. Due to the challenging environment of Rhodiola species, such as high altitude, high radiation, drought, and hypoxia, the source of salidroside is scarce. However, numerous studies have shown that salidroside has a range of biological activities, including cardiovascular and central nervous system activity, and anti-hypoxia, anti-inflammatory, and anti-aging activities. Although previous studies have partially summarized the pharmacological effects of salidroside, the overall pharmacological effects have not been analyzed. Hence, this review will systematically summarize the isolation, purification, synthesis, derivatization, pharmacological activity, pharmacokinetics, clinical application, and safety of salidroside. It is expected to provide new insights for the further research and pharmaceutical development of salidroside.
C1 [Liang, Keke; Ma, Shuhe; Luo, Kai; Wang, Renjie; Li, Maoxing] Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China.
   [Liang, Keke; Ma, Shuhe; Luo, Kai; Wang, Renjie; Xiao, Chenrong; Zhang, Xianxie; Gao, Yue; Li, Maoxing] Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China.
   [Gao, Yue; Li, Maoxing] Natl Key Lab Kidney Dis, Beijing 100850, Peoples R China.
C3 Gansu University of Chinese Medicine; Academy of Military Medical
   Sciences - China
RP Li, MX (corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China.; Gao, Y; Li, MX (corresponding author), Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China.; Gao, Y; Li, MX (corresponding author), Natl Key Lab Kidney Dis, Beijing 100850, Peoples R China.
EM 18394248206@163.com; mclsxka@163.com; 18294623280@163.com;
   wangrenjiegy@163.com; xiaocr@sina.com; zhangxianxie@163.com;
   gaoyue@bmi.ac.cn; limaox2020@aliyun.com
OI zhang, xianxie/0000-0003-3166-3694
FU Traditional Chinese Medicine Innovation Team and Talent Support Program
   Project from National Administration of Traditional Chinese Medicine
   [ZYYCXTDD-202207]; National Natural Science Foundation of China
   [82474196]; Chinese Medicine Service Ability Cultivation and Promotion
   Special key project [2023ZY010]
FX This research was funded by the Traditional Chinese Medicine Innovation
   Team and Talent Support Program Project from National Administration of
   Traditional Chinese Medicine (ZYYCXTDD-202207), National Natural Science
   Foundation of China (82474196), 2023 Chinese Medicine Service Ability
   Cultivation and Promotion Special key project (2023ZY010).
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NR 198
TC 33
Z9 37
U1 38
U2 86
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD DEC
PY 2024
VL 17
IS 12
AR 1703
DI 10.3390/ph17121703
PG 41
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Q3T0M
UT WOS:001383936600001
PM 39770545
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, LH
   Lu, Y
   Huang, GZ
AF Jin, Lianhua
   Lu, Yan
   Huang, Guozhen
TI The potential targets of salidroside in the treatment of pediatric
   epilepsy are revealed by network pharmacology, molecular docking, and
   cell experiments
SO LETTERS IN DRUG DESIGN & DISCOVERY
LA English
DT Article
DE pediatric epilepsy; salidroside; network pharmacology; molecular
   docking; microglia; neuroinflammation
ID MECHANISMS; MANAGEMENT; CHILDREN
AB Background: Salidroside has been reported as a neuroprotective drug in central nervous system diseases, including epilepsy. Herein, this study aimed to explore the potential mechanism of salidroside in pediatric epilepsy (PE). Methods: Targets of salidroside or PE were screened using online databases. The intersection targets were obtained through Venny analysis. String was used for analysis of protein-protein interaction network. Associated pathways were enriched by Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis. The molecular docking was accomplished by the AutoDock Vina. Results: 75 targets of salidroside were found in PE treatment. Interleukin-1 beta (IL1B), Interleukin-6 (IL6), Protein Kinase B alpha 1(AKT1), and Caspase-3 (CASP3) were core therapeutic targets of salidroside for PE. GO and KEGG showed that inflammatory response, lipid, and atherosclerosis were mainly associated pathways. Molecular docking indicated the high binding between salidroside and 4 core targets. Furthermore, salidroside suppressed KA-induced microglia activation and inflammation. Moreover, salidroside treatment could down-regulate the protein expression of IL1B, IL6, AKT1, and CASP3 in KA-induced microglia. Conclusion: Our study found that salidroside might exert the neuroprotective effect by targeting IL1B, IL6, AKT1, or CASP3, providing a new idea for the therapy of for PE.
C1 [Jin, Lianhua; Lu, Yan; Huang, Guozhen] Hubei Polytech Univ, Huangshi Cent Hosp, Affiliated Hosp, Dept Pediat, 141 Tianjin Rd, Huangshi 435000, Hubei, Peoples R China.
C3 Hubei Polytechnic University
RP Huang, GZ (corresponding author), Hubei Polytech Univ, Huangshi Cent Hosp, Affiliated Hosp, Dept Pediat, 141 Tianjin Rd, Huangshi 435000, Hubei, Peoples R China.
EM hgz6662025@163.com
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
SN 1570-1808
EI 1875-628X
J9 LETT DRUG DES DISCOV
JI Lett. Drug Des. Discov.
PD NOV
PY 2025
VL 22
IS 11
AR 100230
DI 10.1016/j.lddd.2025.100230
PG 9
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FC8EC
UT WOS:001715686200001
OA hybrid
DA 2026-05-27
ER

PT J
AU Shi, XM
   Zhao, W
   Yang, YB
   Wu, SC
   Lv, BN
AF Shi, Xiaoming
   Zhao, Wei
   Yang, Yongbin
   Wu, Shengchun
   Lv, Bonan
TI Salidroside could enhance the cytotoxic effect of L-OHP on colorectal
   cancer cells
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE colorectal cancer; salidroside; drug resistance; L-OHP; chemosensitivity
   in vitro
ID RANDOMIZED CONTROLLED-TRIALS; GASTRIC-CANCER; DRUG-RESISTANCE; OXIDATIVE
   STRESS; RHODIOLAE-RADIX; OXALIPLATIN; CHEMOTHERAPY; CONTRIBUTES;
   SENSITIVITY; CARCINOMA
AB Evidence has suggested that salidroside inhibits the proliferation and invasion of renal clear cell, lung, breast, and colon cancer. However, effect of salidroside on colorectal cancer (CRC) cells against oxaliplatin (L-OHP) resistance remains unclear. In the present study, the CRC HT-29 cell line and L-OHP resistance HT-29/L-OHP cell line were used to evaluate the effect, and mechanism of salidroside on L-OHP resistance. The results demonstrated that the activity of HT-29 cells was lower compared with that of HT-29/L-OHP cells following L-OHP intervention, and was accompanied with varied expression levels of drug resistant proteins. The combination of salidroside and L-OHP weakened cell activity significantly compared single utilization. Compared with the control group, salidroside intervention resulted in a higher percentage of HT-29/L-OHP cells in the G(0)/G(1) stage, and reduced percentage in the G(2)/M stage, but no significant variation in the S stage. The HT-29/L-OHP cells exhibited increased apoptosis rates and caspase-3 activity, but decreased metastatic, and invasive abilities following salidroside intervention. Quantitative polymerase chain reaction and western blot analysis detected variations in the expression levels of associated genes in HT-29/L-OHP cells following salidroside intervention. In all, the results of the present study revealed that salidroside is able to decrease the activity and invasive capacity of HT-29/L-OHP cells, and treatment with salidroside is associated with increased apoptosis of cancer cells through the regulation of certain genes.
C1 [Shi, Xiaoming; Zhao, Wei; Yang, Yongbin; Wu, Shengchun; Lv, Bonan] Hebei Gen Hosp, Dept Gen Surg, 348 Heping Western Rd, Shijiazhuang 050051, Hebei, Peoples R China.
RP Shi, XM (corresponding author), Hebei Gen Hosp, Dept Gen Surg, 348 Heping Western Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM shixiaoming1999@126.com
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NR 46
TC 16
Z9 18
U1 2
U2 22
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2018
VL 17
IS 1
BP 51
EP 58
DI 10.3892/mmr.2017.7846
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FT8WG
UT WOS:000423433300006
PM 29115408
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zheng, T
   Yang, XY
   Wu, D
   Xing, SS
   Bian, F
   Li, WJ
   Chi, JY
   Bai, XL
   Wu, GJ
   Chen, XQ
   Zhang, YH
   Jin, S
AF Zheng, Tao
   Yang, Xiaoyan
   Wu, Dan
   Xing, Shasha
   Bian, Fang
   Li, Wenjing
   Chi, Jiangyang
   Bai, Xiangli
   Wu, Guangjie
   Chen, Xiaoqian
   Zhang, Yonghui
   Jin, Si
TI Salidroside ameliorates insulin resistance through activation of a
   mitochondria-associated AMPK/PI3K/Akt/GSK3 pathway
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; TRANSCRIPTION FACTOR FOXO1;
   PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE/AKT; CHEMOATTRACTANT
   PROTEIN-1; HEPATIC GLUCONEOGENESIS; SKELETAL-MUSCLE; GLUCOSE-UPTAKE;
   CONCISE GUIDE; DRUG TARGETS
AB Background and PurposeRecent reports have suggested that salidroside could protect cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK). The aim of this study was to evaluate the therapeutic effects of salidroside on diabetic mice and to explore the underlying mechanisms.
   Experimental ApproachThe therapeutic effects of salidroside on type 2 diabetes were investigated. Increasing doses of salidroside (25, 50 and 100mgkg(-1)day(-1)) were administered p.o. to db/db mice for 8 weeks. Biochemical analysis and histopathological examinations were conducted to evaluate the therapeutic effects of salidroside. Primary cultured mouse hepatocytes were used to further explore the underlying mechanisms in vitro.
   Key ResultsSalidroside dramatically reduced blood glucose and serum insulin levels and alleviated insulin resistance. Hypolipidaemic effects and amelioration of liver steatosis were observed after salidroside administration. In vitro, salidroside dose-dependently induced an increase in the phosphorylations of AMPK and PI3K/Akt, as well as glycogen synthase kinase 3 (GSK3) in hepatocytes. Furthermore, salidroside-stimulated AMPK activation was found to suppress the expression of PEPCK and glucose-6-phosphatase. Salidroside-induced AMPK activation also resulted in phosphorylation of acetyl CoA carboxylase, which can reduce lipid accumulation in peripheral tissues. In isolated mitochondria, salidroside inhibited respiratory chain complex I and disturbed oxidation/phosphorylation coupling and moderately depolarized the mitochondrial membrane potential, resulting in a transient increase in the AMP/ATP ratio.
   Conclusions and ImplicationsSalidroside exerts an antidiabetic effect by improving the cellular metabolic flux through the activation of a mitochondria-related AMPK/PI3K/Akt/GSK3 pathway
C1 [Zheng, Tao; Yang, Xiaoyan; Wu, Dan; Xing, Shasha; Bian, Fang; Li, Wenjing; Chi, Jiangyang; Bai, Xiangli; Wu, Guangjie; Chen, Xiaoqian; Zhang, Yonghui; Jin, Si] Huazhong Univ Sci & Technol, Dept Pharmacol, Sch Basic Med, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
   [Zheng, Tao; Yang, Xiaoyan; Wu, Dan; Xing, Shasha; Bian, Fang; Li, Wenjing; Chi, Jiangyang; Bai, Xiangli; Wu, Guangjie; Chen, Xiaoqian; Zhang, Yonghui; Jin, Si] Key Lab Nat Med Chem Drug Target Res & Pharmacody, Wuhan, Hubei, Peoples R China.
   [Jin, Si] Huazhong Univ Sci & Technol, Dept Endocrinol, Tongji Med Coll, Inst Geriatr Med,Liyuan Hosp, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Dept Pharmacol, Sch Basic Med,Dept Endocrinol, Inst Geriatr Med,Liyuan Hosp,Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM zhangyh@mails.tjmu.edu.cn; Jinsi@mail.hust.edu.cn
RI Zheng, Tao/JOZ-1467-2023; jin, si/KGK-5977-2024; xing,
   shasha/JFB-2393-2023; Zhang, Yonghui/AGY-5688-2022
OI Zheng, Tao/0000-0003-1742-1357; jin, si/0000-0003-0727-6715; 
FU National Natural Science Foundation of China [81373413, 81072634,
   81470458, 81070190]; Ministry of Education of China [NCET-10-0409,
   2013YGYL008]; National Science and Technology Major Projects
   [2013zx09103-001-020, 2011zx09102-004-001]
FX This work was supported by grant from the National Natural Science
   Foundation of China (81373413, 81072634, 81470458 and 81070190), grants
   from the Ministry of Education of China (NCET-10-0409, 2013YGYL008) as
   well as from the National Science and Technology Major Projects
   (2013zx09103-001-020, 2011zx09102-004-001).
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NR 63
TC 210
Z9 228
U1 2
U2 108
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JUL
PY 2015
VL 172
IS 13
SI SI
BP 3284
EP 3301
DI 10.1111/bph.13120
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CL1HN
UT WOS:000356693500009
PM 25754463
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Li, X
   Sipple, J
   Pang, QS
   Du, W
AF Li, Xue
   Sipple, Jared
   Pang, Qishen
   Du, Wei
TI Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC
   maintenance
SO BLOOD
LA English
DT Article
ID HEMATOPOIETIC STEM-CELLS; NUCLEOTIDE EXCISION-REPAIR; LOW-DOSE REGIMEN;
   OXIDATIVE STRESS; RHODIOLA-ROSEA; SELF-RENEWAL; ANTIOXIDANT ACTIVITY;
   DOUBLE-BLIND; COMET ASSAY; IN-VIVO
AB Salidroside is a phenylpropanoid glycoside isolated from the medicinal plant Rhodiola rosea, which has potent antioxidant properties. Here we show that salidroside prevented the loss of hematopoietic stem cells (HSCs) in mice under oxidative stress. Quiescent HSCs were recruited into cell cycling on in vivo challenge with oxidative stress, which was blocked by salidroside. Surprisingly, salidroside does not prevent the production of reactive oxygen species but reduces hydrogen peroxide-induced DNA-strand breaks in bone marrow cells enriched for HSCs. We tested whether salidroside enhances oxidative DNAdamage repair in mice deficient for 5 DNA repair pathways known to be involved in oxidative DNA damage repair; we found that salidroside activated poly(ADPribose) polymerase-1 (PARP-1), a component of the base excision repair pathway, in mouse bone marrow HSCs as well as primary fibroblasts and human lymphoblasts. PARP-1 activation by salidroside protects quiescent HSCs from oxidative stress-induced cycling in native animals and self-renewal defect in transplanted recipients, which was abrogated by genetic ablation or pharmacologic inhibition of PARP-1. Together, these findings suggest that activation of PARP-1 by salidroside could affect the homeostasis and function of HSCs and contribute to the antioxidant effects of salidroside. (Blood. 2012;119(18):4162-4173)
C1 [Li, Xue; Sipple, Jared; Pang, Qishen; Du, Wei] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA.
   [Li, Xue] S China Normal Univ, Coll Life Sci, Guangzhou, Guangdong, Peoples R China.
   [Pang, Qishen] Univ Cincinnati Coll Med, Dept Pediat, Cincinnati, OH USA.
C3 Cincinnati Children's Hospital Medical Center; South China Normal
   University; University System of Ohio; University of Cincinnati
RP Du, W (corresponding author), Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA.
EM wei.du@cchmc.org
RI Du, Wei/ABD-4748-2020
OI Du, Wei/0000-0003-3669-537X
FU South China Normal University; National Institutes of Health (NIH) [R01
   HL076712, R01 CA157537]; Leukemia & Lymphoma Scholar award
FX This work was supported by a Visiting Scholarship from South China
   Normal University (X.L.) and partially by National Institutes of Health
   (NIH) grants R01 HL076712 and R01 CA157537. Q.P. is supported by a
   Leukemia & Lymphoma Scholar award. W.D. is supported by an NIH T32
   training grant.
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NR 50
TC 43
Z9 51
U1 1
U2 11
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD MAY 3
PY 2012
VL 119
IS 18
BP 4162
EP 4173
DI 10.1182/blood-2011-10-387332
PG 12
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA 959BL
UT WOS:000305284600013
PM 22427203
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Li, YT
   Li, SZ
   Hu, QG
   Huang, PP
AF Li Yuetong
   Li Shangzhu
   Hu Qingun
   Huang Pingping
TI Salidroside inhibits proliferation, migration and invasion of human
   pancreatic cancer PANC1 and SW1990 cells through the AKT and ERK
   signaling pathway
SO PHARMAZIE
LA English
DT Article
ID RHODIOLA-ROSEA; IN-VITRO; GROWTH
AB Salidroside is the main compounds extracted from the Chinese medicine Rhodiola rosea and has many pharmacological effects, including anti-tumor effects. However, the role of salidroside in human pancreatic cancer remains poorly known. Thus, the focus of this study was to evaluate the inhibitory effect of purified salidroside on human pancreatic cancer cells and its underlying molecular mechanisms. PANC1 and SW1990 cells were incubated with various concentrations of salidroside, and CCK-8 assay, colony formation, apoptosis, migration and invasion, western blot were conducted. As a result, it was found that salidroside significantly inhibited pancreatic cancer cells viability, proliferation, migration and invasion, and also induced cell apoptosis. Furthermore, we also detected that salidroside inhibited pancreatic cancer cells by downregulating the AKT and ERK signaling pathways. In conclusion, these findings suggest that salidroside may be a promising candidate for the development of a therapy of human pancreatic cancer.
C1 [Li Yuetong] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
   [Li Shangzhu; Hu Qingun; Huang Pingping] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Institute of Hematology
   & Blood Diseases Hospital - CAMS; Peking Union Medical College
RP Huang, PP (corresponding author), Inst Hematol & Blood Dis Hosp, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol, Tianjin, Peoples R China.
EM huangpp66@aliyun.com
FU CAMS Innovation Fund for Medical Science [2017-I2M-1-016]
FX This research was funded by CAMS Innovation Fund for Medical Science
   (Grant number: 2017-I2M-1-016).
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NR 31
TC 13
Z9 14
U1 1
U2 12
PU IMR PRESS
PI SINGAPORE
PA #07-07, 151 CHIN SWEE ROAD, MANHATTAN HOUSE, SINGAPORE, SINGAPORE
SN 0031-7144
EI 3053-691X
J9 PHARMAZIE
JI Pharmazie
PD AUG
PY 2020
VL 75
IS 8
BP 385
EP 388
DI 10.1691/ph.2020.0556
PG 4
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry
GA OP8NM
UT WOS:000588347100005
PM 32758338
DA 2026-05-27
ER

PT J
AU Wang, XP
   Yuan, DY
   Tian, Y
   Li, WH
AF Wang, X-P
   Yuan, D-Y
   Tian, Y.
   Li, W-H
TI Multiple mechanisms of salidroside on anti-tumor effects
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Salidroside; Tumor; Cell cycle; Apoptosis; Autophagy; Differentiation
ID DEPENDENT AUTOPHAGY; RETINOIC ACID; CANCER CELLS; INHIBITION; APOPTOSIS;
   PROLIFERATION; EXPRESSION; MIGRATION; GROWTH; INVASION
AB Salidroside, a kind of natural herb, has the advantages of a wide range of anti-tumor activities with low toxicity and high efficiency. A large number of studies have shown that salidroside can inhibit the proliferation of tumors in different ways and achieve the goal of treating tumors. After summary and analysis of the recent research on anti-tumor mechanisms of salidroside, it can be concluded that salidroside could suppress cancer proliferation by blocking cell cycle, promoting cell differentiation, inducing cell apoptosis or autophagy, and regulating the signal pathways of cancer cells.
C1 [Wang, X-P; Yuan, D-Y; Tian, Y.; Li, W-H] Xizang Minzu Univ, Dept Med, Xianyang, Peoples R China.
C3 Xizang Minzu University
RP Wang, XP (corresponding author), Xizang Minzu Univ, Dept Med, Xianyang, Peoples R China.
EM wxpphd@aliyun.com
FU Key Scientific Research Program of Xizang Minzu University and Xizang
   Autonomous Region [20MDT02, XZ202101ZR0074G]; Shaanxi Provincial
   Education Department [18JS031]; Scientific Research Program of Shaanxi
   Administration of Traditional Chinese Medicine [15-SCJH001, JCPT001];
   Natural Science Basic Research Plan in Shaanxi Province of China
   [2016JM8023, 2020JM-590]
FX This work is supported by the Key Scientific Research Program of Xizang
   Minzu University and Xizang Autonomous Region (No. 20MDT02,
   XZ202101ZR0074G), Scientific Research Program Funded by Shaanxi
   Provincial Education Department (No. 18JS031), the Scientific Research
   Program of Shaanxi Administration of Traditional Chinese Medicine (No.
   15-SCJH001, JCPT001), and the Natural Science Basic Research Plan in
   Shaanxi Province of China (No. 2016JM8023, 2020JM-590).
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NR 56
TC 15
Z9 19
U1 1
U2 35
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2021
VL 25
IS 17
BP 5349
EP 5354
DI 10.26355/eurrev_202109_26641
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UP8WK
UT WOS:000695653800006
PM 34533789
DA 2026-05-27
ER

PT J
AU Zhang, X
   Lai, W
   Ying, X
   Xu, L
   Chu, K
   Brown, J
   Chen, L
   Hong, G
AF Zhang, X.
   Lai, W.
   Ying, X.
   Xu, L.
   Chu, K.
   Brown, J.
   Chen, L.
   Hong, G.
TI Salidroside Reduces Inflammation and Brain Injury After Permanent Middle
   Cerebral Artery Occlusion in Rats by Regulating PI3K/PKB/Nrf2/NFκB
   Signaling Rather than Complement C3 Activity
SO INFLAMMATION
LA English
DT Article
DE Complement C3; Inflammation; Ischemic stroke; Neuroprotection; Nrf2;
   Salidroside
ID NF-KAPPA-B; ANTIOXIDANT RESPONSE; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE
   STRESS; NRF2; ISCHEMIA; INDUCTION; STROKE; HO-1; NEUROPROTECTION
AB Salidroside, an active constituent of Rhodiola rosea, is neuroprotective after transient middle cerebral artery occlusion (tMCAO). However, its effects in other experimental stroke models are less understood. Here, we investigated the effect of daily intraperitoneal injections of salidroside in rats after permanent MCAO (pMCAO). Cerebral infarct volumes at 1 day after pMCAO were significantly reduced by treatment with 100 mg/kg/day salidroside, but not by 25 or 50 mg/kg/day, and this benefit of salidroside increased significantly over at least 7 days of treatment, when it was also accompanied by decreased neurological deficit scores. These observations led us to investigate the underlying mechanism of action of salidroside. 100 mg/kg salidroside for 1 day increased NeuN, Nrf2, and its downstream mediator HO-1, while it reduced nuclear NF kappa B p50, IL-6, and TNF alpha. Brusatol, a Nrf2 inhibitor, blocked the actions of salidroside on Nrf2, NF kappa B p50, IL-6, and TNF alpha. Salidroside also increased the ratio of p-PKB/PKB at 1 day after pMCAO even in the presence of brusatol. LY294002, a PI3K inhibitor, prevented all these effects of salidroside, including those on NeuN, p-PKB/PKB, Nrf2, HO-1, and pro-inflammatory mediators. In contrast, salidroside had no significant effect on the level of cerebral complement C3 after pMCAO, or on the activity of C3 as measured by the expression of cerebral Egr1. Our findings therefore suggest that salidroside reduces neuroinflammation and neural damage by regulating the PI3K/PKB/Nrf2/NF kappa B signaling pathway after pMCAO, and that this neuroprotective effect does not involve modulation of complement C3 activity.
C1 [Zhang, X.; Lai, W.; Ying, X.; Xu, L.; Chu, K.; Brown, J.; Chen, L.; Hong, G.] Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Hong, G (corresponding author), Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Fujian, Peoples R China.
EM guizhuhong@fjtcm.edu.cn
RI ; Chen, Lidian/GSN-6461-2022
OI Hong, Guizhu/0000-0003-3932-4777; Chen, Lidian/0000-0002-8699-0839
FU National Natural Science Foundation of China [81473382, 81603323];
   Collaborative Innovation Center for Rehabilitation Technology of Fujian
   University of TCM; TCM Rehabilitation Research of SATCM [X2018002]
FX This work was supported by the National Natural Science Foundation of
   China (projects 81473382 and 81603323), by the Collaborative Innovation
   Center for Rehabilitation Technology of Fujian Un iversity of TCM, and
   by the TCM Rehabilitation Research of SATCM (X2018002-Collaborative).
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NR 37
TC 51
Z9 57
U1 2
U2 37
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD OCT
PY 2019
VL 42
IS 5
BP 1830
EP 1842
DI 10.1007/s10753-019-01045-7
PG 13
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA IU5XG
UT WOS:000483660100029
PM 31230155
DA 2026-05-27
ER

PT J
AU Xie, BC
   Zhou, H
   Liu, HY
   Liao, SY
   Zhou, CH
   Xu, DH
AF Xie, Baocheng
   Zhou, Huan
   Liu, Hongyu
   Liao, Shiyi
   Zhou, Chenhui
   Xu, Daohua
TI Salidroside alleviates dexamethasone-induced inhibition of bone
   formation via transforming growth factor-beta/Smad2/3 signaling pathway
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE glucocorticoid; osteoblast differentiation; osteoporosis; salidroside;
   TGF-beta; Smad2; 3 signaling pathway
ID OSTEOBLAST DIFFERENTIATION; OSTEOPOROSIS; EXTRACT; UPDATE
AB Glucocorticoid-induced osteoporosis is the third epidemic osteoporosis following postmenopausal and senileosteoporosis. According to one study, salidroside made ovariectomized rats' bones strong. Salidroside's potential for treating glucocorticoid-induced osteoporosis remains unproven. This study aimed to investigate the protective effect and mechanism of salidroside on dexamethasone-induced osteogenic differentiation and bone formation in MC3T3-E1 cells and zebrafish. The study proved that salindroside had no harmful impact on MC3T3E1 cells. Salidroside significantly relieved dexamethasone-induced inhibition of ALP (alkaline phosphatase) activity and mineralization in MC3T3-E1 cells, and promoted osteogenic differentiation of cells. Salidroside increased the expression of osteopontin (OPN), runt-related transcription factor 2 (Runx2), osterix (Osx), transforming growth factor-beta (TGF-beta) proteins and promoted the phosphorylation of Smad2/3 in MC3T3-E1 cells treated with dexamethasone. In addition, the effect of salidroside in relieving dexamethasone-induced inhibition of osteogenic differentiation in MC3T3-E1 cells can be blocked by TGF-beta receptor type I/II inhibitor (LY2109761). At the same time, we found that salidroside significantly alleviated the inhibition of dexamethasone-induced bone formation in zebrafish and promoted the mineralization of zebrafish skulls. LY2109761 reversed the protective impact of salidroside on dexamethasone-mediated bone impairment in zebrafish. These findings suggested that salidroside alleviated dexamethasone-induced inhibition of osteogenic differentiation and bone formation via TGF-beta /Smad2/3 signaling pathway.
C1 [Xie, Baocheng; Zhou, Huan; Liu, Hongyu; Liao, Shiyi; Xu, Daohua] Guangdong Med Univ, Sch Pharm, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang, Peoples R China.
   [Xie, Baocheng] Southern Med Univ, Affiliated Dongguan Hosp, Dept Pharm, Dongguan, Peoples R China.
   [Zhou, Huan; Liu, Hongyu; Liao, Shiyi; Xu, Daohua] Guangdong Med Univ, Dept Pharmacol, Key Lab Tradit Chinese Med & New Pharmaceut Dev, Dongguan, Peoples R China.
   [Zhou, Chenhui] Guangdong Med Univ, Sch Nursing, Dongguan, Peoples R China.
C3 Guangdong Medical University; Southern Medical University - China;
   Guangdong Medical University; Guangdong Medical University
RP Xu, DH (corresponding author), Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China.
EM daohuax108@163.com
RI ; Xie, baocheng/GQQ-8354-2022; Liao, Shiyi/HTQ-5043-2023
OI Liu, Hongyu/0009-0002-2167-965X; Xie, baocheng/0000-0002-7109-402X;
   zhou, huan/0009-0007-9391-4299; 
FU Guangdong Basic and Applied Basic Research Foundation [2021A1515010151,
   2021B1515140054] Funding Source: Medline; National Natural Science
   Foundation of China [82000842] Funding Source: Medline; Discipline
   construction project of Guangdong Medical University [4SG21002G] Funding
   Source: Medline; Dongguan Science and technology of social development
   Program [202050715001197] Funding Source: Medline
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NR 33
TC 16
Z9 25
U1 4
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAY
PY 2023
VL 37
IS 5
BP 1938
EP 1950
DI 10.1002/ptr.7711
EA DEC 2022
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M8KW1
UT WOS:000903910200001
PM 36567454
DA 2026-05-27
ER

PT J
AU Fan, XJ
   Wang, Y
   Wang, L
   Zhu, MY
AF Fan, Xiang-Jun
   Wang, Yao
   Wang, Lei
   Zhu, Mingyan
TI Salidroside induces apoptosis and autophagy in human colorectal cancer
   cells through inhibition of PI3K/Akt/mTOR pathway
SO ONCOLOGY REPORTS
LA English
DT Article
DE autophagy; apoptosis; human colon cancer HT-29 cells; salidroside;
   PI3K/Akt/mTOR pathways
ID SIGNALING PATHWAYS; COLON-CANCER; G(2)/M ARREST; CYCLE ARREST; P38 MAPK;
   DEATH; INDUCTION; PLUMBAGIN; GROWTH; MTOR
AB The role of salidroside in colon cancer remains unknown. Here we show that salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea, exhibited potent anti-proliferative properties in human colorectal cancer cells via inducing apoptosis and autophagy. We ascertained that salidroside exerts an inhibitory effect on the proliferation of human colorectal cancer cells in a dose-dependent manner. In addition, salidroside induced cell apoptosis, accompanied by an increase of chromatin condensation and nuclear fragmentation, and a decrease of Bcl-2/Bax protein expression ratio. We also found that salidroside induced autophagy, evidenced by increased LC3(+) autophagic vacuoles, positive acridine orange-stained cells, enhanced conversion of LC3-I to LC3-II, and elevation of Beclin-1. Treatment with autophagy-specific inhibitors [3-methyladenine (3-MA) and bafilomycin A1 (BA)] enhanced salidroside-induced apoptosis, indicating that salidroside-mediated autophagy may protect HT29 cells from undergoing apoptotic cell death. Additionally, salidroside decreased the phosphorylation of PI3K, Akt and mTOR. Treatment with PI3K inhibitor LY294002 augmented the effects of salidroside on the expression of Akt and mTOR. These findings indicate that salidroside could suppress the PI3K/Akt/mTOR signaling pathways. This study may provide a rationale for future clinical application using salidroside as a chemotherapeutic agent for human colorectal cancer.
C1 [Fan, Xiang-Jun; Wang, Yao; Wang, Lei; Zhu, Mingyan] Nantong Univ, Affiliated Hosp, Dept Gen Surg, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University
RP Zhu, MY (corresponding author), Nantong Univ, Affiliated Hosp, Dept Gen Surg, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China.
EM zmyntfy@163.com
RI Zhu, Mingyan/KHU-0365-2024
FU Technological Innovation and Demonstration of Social Undertakings
   Projects of Nantong, Jiangsu, China [HS2014049]
FX This study was supported by the Technological Innovation and
   Demonstration of Social Undertakings Projects (HS2014049) of Nantong,
   Jiangsu, China.
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NR 59
TC 112
Z9 132
U1 1
U2 54
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1021-335X
EI 1791-2431
J9 ONCOL REP
JI Oncol. Rep.
PD DEC
PY 2016
VL 36
IS 6
BP 3559
EP 3567
DI 10.3892/or.2016.5138
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ED2DG
UT WOS:000388653200057
PM 27748934
OA Bronze
DA 2026-05-27
ER

PT J
AU Guo, Z
   Liu, FY
   Yang, D
   Wang, MY
   Li, CF
   Tang, N
   Ma, SQ
   An, P
   Yang, Z
   Tang, QZ
AF Guo, Zhen
   Liu, Fang-Yuan
   Yang, Dan
   Wang, Ming-Yu
   Li, Chen-Fei
   Tang, Nan
   Ma, Shu-Qing
   An, Peng
   Yang, Zheng
   Tang, Qi-Zhu
TI Salidroside ameliorates pathological cardiac hypertrophy via
   TLR4-TAK1-dependent signaling
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE hypertrophy; salidroside; TAK1; TLR4
ID PRESSURE-OVERLOAD; PROTEIN-KINASES; ACTIVATION; INFLAMMATION; APOPTOSIS;
   RECEPTOR; CELLS; TAK1; CARDIOMYOCYTES; RATS
AB Salidroside, a prominent active ingredient in traditional Chinese medicines, is garnering increased attention because of its unique pharmacological effects against ischemic heart disease via MAPK signaling, which plays a critical role in regulating the evolution of ventricular hypertrophy. However, the function of Salidroside on myocardial hypertrophy has not yet been elucidated. C57BL/6 mice were subjected to transverse aortic constriction (TAC), and treated with Salidroside (100 mg kg(-1) day(-1)) by oral gavage for 3 weeks starting 1 week after surgery. Four weeks after TAC surgery, the mice were subjected to echocardiography and then sacrificed to harvest the hearts for analysis. For in vitro study, neonatal rat cardiomyocytes were used to validate the protective effects of Salidroside in response to Angiotensin II (Ang II, 1 mu M) stimulation. Here, we proved that Salidroside dramatically inhibited hypertrophic reactions generated by pressure overload and isoproterenol (ISO) injection. Salidroside prevented the activation of the TAK1-JNK/p38 axis. Salidroside pretreatment of TAK1-inhibited cardiomyocytes shows no additional attenuation of Ang II-induced cardiomyocytes hypertrophy and signaling pathway activation. The overexpression of constitutively active TAK1 removed the protective effects of Salidroside on myocardial hypertrophy. TAC-induced increase of TLR4 protein expression was reduced considerably in the Salidroside treated mice. Transient transfection of small interfering RNA targeting TLR4 (siTLR4) in cardiomyocytes did not further decrease the activation of the TAK1/JNK-p38 axis. In conclusion, Salidroside functioned as a TLR4 inhibitor and displayed anti-hypertrophic action via the TAK1/JNK-p38 pathway.
C1 [Guo, Zhen; Liu, Fang-Yuan; Yang, Dan; Wang, Ming-Yu; Li, Chen-Fei; Tang, Nan; Ma, Shu-Qing; An, Peng; Yang, Zheng; Tang, Qi-Zhu] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Peoples R China.
   [Guo, Zhen; Liu, Fang-Yuan; Yang, Dan; Wang, Ming-Yu; Li, Chen-Fei; Tang, Nan; Ma, Shu-Qing; An, Peng; Yang, Zheng; Tang, Qi-Zhu] Hubei Key Lab Metab & Chron Dis, Wuhan, Peoples R China.
   [Tang, Qi-Zhu] Wuhan Univ, Dept Cardiol, Cardiovasc Res Inst, Hubei Key Lab Metab & Chron Dis,Renmin Hosp, Jiefang Rd 238, Wuhan 430060, Peoples R China.
C3 Wuhan University; Wuhan University
RP Tang, QZ (corresponding author), Wuhan Univ, Dept Cardiol, Cardiovasc Res Inst, Hubei Key Lab Metab & Chron Dis,Renmin Hosp, Jiefang Rd 238, Wuhan 430060, Peoples R China.
EM qztang@whu.edu.cn
RI ; Li, Chenfei/AEO-2027-2022; Yang, Dan/LSJ-7959-2024
OI Tang, Qizhu/0000-0003-2210-3169; Yang, Dan/0009-0005-9065-305X
FU National Natural Science Foundation of China [81530012]
FX National Natural Science Foundation of China, Grant/Award Number:
   81530012
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NR 47
TC 9
Z9 11
U1 2
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAY
PY 2023
VL 37
IS 5
BP 1839
EP 1849
DI 10.1002/ptr.7701
EA DEC 2022
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M8KW1
UT WOS:000897878300001
PM 36512326
DA 2026-05-27
ER

PT J
AU Zeng, W
   Xiao, T
   Cai, AL
   Cai, WL
   Liu, HH
   Liu, JL
   Li, J
   Tan, MD
   Xie, L
   Liu, Y
   Yang, XC
   Long, Y
AF Zeng, Wei
   Xiao, Tao
   Cai, Anlie
   Cai, Weiliang
   Liu, Huanhuan
   Liu, Jingling
   Li, Jie
   Tan, Miduo
   Xie, Li
   Liu, Ying
   Yang, Xiangcheng
   Long, Yi
TI Inhibiting ROS-TFEB-Dependent Autophagy Enhances Salidroside-Induced
   Apoptosis in Human Chondrosarcoma Cells
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Salidroside; Autophagy; TFEB; Reactive Oxygen Species; Apoptosis;
   Chondrosarcoma
ID CELLULAR CLEARANCE; CANCER-CELLS; LYSOSOME; GROWTH; DEATH; ACTIVATION;
   MITOPHAGY
AB Background/Aims: Autophagy modulation has been considered a potential therapeutic strategy for human chondrosarcoma, and a previous study indicated that salidroside exhibits significant anti-carcinogenic activity. However, the ability of salidroside to induce autophagy and its role in human chondrosarcoma cell death remains unclear. Methods: We exposed SW1353 cells to different concentrations of salidroside (0.5, 1 and 2 mM) for 24 h. RT-PCR, Western-blotting, Immunocytofluorescence, and Luciferase Reporter Assays were used to evaluate whether salidroside activated the TFEB-dependent autophagy. Results: We show that salidroside induced significant apoptosis in the human chondrosarcoma cell line SW1353. In addition, we demonstrate that salidroside-induced an autophagic response in SW1353 cells, as evidenced by the upregulation of LC3-II and downregulation of P62. Moreover, pharmacological or genetic blocking of autophagy enhanced salidroside - induced apoptosis, indicating the cytoprotective role of autophagy in salidroside-treated SW1353 cells. Salidroside also induced TFEB ((Ser142)) dephosphorylation, subsequently to activated TFEB nuclear translocation and increase of TFEB reporter activity, which contributed to lysosomal biogenesis and the expression of autophagy-related genes. Importantly, we found that salidroside triggered the generation of ROS in SW1353 cells. Furthermore, NAC, a ROS scavenger, abrogated the effects of salidroside on TFEB-dependent autophagy. Conclusions: These data demonstrate that salidroside increased TFEB-dependent autophagy by activating ROS signaling pathways in human chondrosarcoma cells. These data also suggest that blocking ROS-TFEB-dependent autophagy to enhance the activity of salidroside warrants further attention in treatment of human chondrosarcoma cells. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Zeng, Wei; Xiao, Tao; Cai, Weiliang] Cent South Univ, Dept Orthoped Surg, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
   [Zeng, Wei; Cai, Anlie; Liu, Jingling; Li, Jie; Liu, Ying; Yang, Xiangcheng; Long, Yi] Cent South Univ, Dept Orthoped Surg, Cent Hosp Zhuzhou City, Changsha, Hunan, Peoples R China.
   [Zeng, Wei; Cai, Anlie; Liu, Huanhuan; Liu, Jingling; Li, Jie; Tan, Miduo; Xie, Li; Liu, Ying; Yang, Xiangcheng; Long, Yi] Cent South Univ, Affiliated Zhuzhou Hosp, Xiangya Med Coll, Changsha, Hunan, Peoples R China.
   [Liu, Huanhuan] Cent South Univ, Dept Infect Dis, Cent Hosp Zhuzhou City, Changsha, Hunan, Peoples R China.
   [Tan, Miduo] Cent South Univ, Surg Dept Galactophore, Cent Hosp Zhuzhou City, Changsha, Hunan, Peoples R China.
   [Xie, Li] Cent South Univ, Dept Intergrated Tradit Chinese Med & Western Med, Cent Hosp Zhuzhou City, Changsha, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Central South University; Central South University; Central
   South University
RP Xiao, T (corresponding author), Cent South Univ, Dept Orthoped Surg, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
EM xiaotaosci2017@163.com
OI Xiao, Tao/0000-0003-2331-2034
FU Medical Scientific Research Project of the Hunan province of China
   [B2016172]; Natural Science Foundation of Hunan province of China
   [2017JJ4068]
FX This work was supported by the Medical Scientific Research Project of
   the Hunan province of China (No. B2016172) and the Natural Science
   Foundation of Hunan province of China (No. 2017JJ4068).
CR [Anonymous], ONCOTARGET
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NR 49
TC 26
Z9 31
U1 0
U2 21
PU Cell Physiol Biochem Press GmbH & Co
PI Dsseldorf
PA Herzogstr. 85, Dsseldorf, GERMANY
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2017
VL 43
IS 4
BP 1487
EP 1502
DI 10.1159/000481971
PG 16
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FN7TY
UT WOS:000416222900016
PM 29035891
OA gold
DA 2026-05-27
ER

PT J
AU Liu, H
   Lv, PZ
   Wu, HY
   Zhang, K
   Xu, FB
   Zheng, L
   Zhao, JM
AF Liu, Hui
   Lv, Peizhen
   Wu, Huayu
   Zhang, Kun
   Xu, Fuben
   Zheng, Li
   Zhao, Jinmin
TI The Proliferation Enhancing Effects of Salidroside on Schwann Cells In
   Vitro
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; CILIARY NEUROTROPHIC FACTOR; AXONAL
   REGENERATION; INJURY; NERVE; RAT; EXPRESSION; GDNF; ACTIVATION;
   APOPTOSIS
AB Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects. Recent studies show that salidroside has neurotrophic and neuroprotective effects. However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the salidroside-induced neurotrophin secretion have seldom been studied. In this study, the effect of salidroside on the survival, proliferation, and gene expression of Schwann cells lineage (RSC96) was studied through the examinations of the cell viability, proliferation, morphology, and expression of neurotrophic factor related genes including BDNF, GDNF, and CDNF at 2, 4, and 6 days, respectively. These results showed that salidroside significantly enhanced survival and proliferation of SCs. The underlying mechanism might involve that salidroside affected SCs growth through the modulation of several neurotrophic factors including BDNF, GDNF, and CDNF. As for the concentration, 0.4 mM, 0.2 mM, and 0.1mM of salidroside were recommended, especially 0.2 mM. This investigation indicates that salidroside is capable of enhancing SCs survival and function in vitro, which highlights the possibility that salidroside as a drug agent to promote nerve regeneration in cellular nerve scaffold through salidroside-induced neurotrophin secretion in SCs.
C1 [Liu, Hui; Lv, Peizhen; Zhang, Kun; Zheng, Li; Zhao, Jinmin] Guangxi Med Univ, Affiliated Hosp 1, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Nanning, Peoples R China.
   [Liu, Hui; Zhang, Kun; Zhao, Jinmin] Guangxi Med Univ, Affiliated Hosp 1, Dept Orthopaed Trauma & Hand Surg, Nanning, Peoples R China.
   [Liu, Hui; Zheng, Li; Zhao, Jinmin] Guangxi Med Univ, Affiliated Hosp 1, Guangxi Collaborat Innovat Ctr Biomed, Nanning, Peoples R China.
   [Lv, Peizhen] Guangxi Med Univ, Dept Spine Surg, Affiliated Hosp 3, Nanning, Peoples R China.
   [Wu, Huayu] Guangxi Med Univ, Sch Premed Sci, Dept Cell Biol & Genet, Nanning, Peoples R China.
   [Xu, Fuben] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Childrens Hosp, Dept Genet Metab, Nanning 530003, Peoples R China.
   [Xu, Fuben] Guangxi Ctr Birth Defects Res & Prevent, Nanning 530003, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University; Guangxi Medical University
RP Zheng, L; Zhao, JM (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Nanning, Peoples R China.; Zhao, JM (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Dept Orthopaed Trauma & Hand Surg, Nanning, Peoples R China.; Zheng, L; Zhao, JM (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Guangxi Collaborat Innovat Ctr Biomed, Nanning, Peoples R China.
EM zhengli@gxmu.edu.cn; zhaojinmin@126.com
RI ; Zhao, Jinmin/LBH-0351-2024
OI Zheng, Li/0000-0002-9666-0024; Zheng, Li/0000-0003-1995-4165; Zhao,
   Jinmin/0000-0002-1047-8820
FU National Natural Science Foundation of China [81160221]; Guangxi
   Scientific Research and Technological Development Foundation
   [1598013-15]; Innovation Project of Guangxi Graduate Education of China
   [YCSZ2015126]
FX This work has been financially supported by National Natural Science
   Foundation of China (Grant no. 81160221), Guangxi Scientific Research
   and Technological Development Foundation (1598013-15), and Innovation
   Project of Guangxi Graduate Education of China (Grant no. YCSZ2015126).
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NR 41
TC 13
Z9 13
U1 1
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 4673289
DI 10.1155/2017/4673289
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EX4XW
UT WOS:000403240100001
PM 28680451
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Hu, HX
   Li, ZF
   Zhu, XQ
   Lin, RH
   Chen, LD
AF Hu, Haixia
   Li, Zuanfang
   Zhu, Xiaoqin
   Lin, Ruhui
   Chen, Lidian
TI Salidroside Reduces Cell Mobility via NF-κB and MAPK Signaling in
   LPS-Induced BV2 Microglial Cells
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID MECHANISMS; EXPRESSION; STROKE
AB The unregulated activation of microglia following stroke results in the production of toxic factors that propagate secondary neuronal injury. Salidroside has been shown to exhibit protective effects against neuronal death induced by different insults. However, the molecular mechanisms responsible for the anti-inflammatory activity of salidroside have not been elucidated clearly in microglia. In the present study, we investigated the molecular mechanism underlying inhibiting LPS-stimulated BV2 microglial cell mobility of salidroside. The protective effect of salidroside was investigated in microglial BV2 cell, subjected to stretch injury. Moreover, transwell migration assay demonstrated that salidroside significantly reduced cell motility. Our results also indicated that salidroside suppressed LPS-induced chemokines production in a dose-dependent manner, without causing cytotoxicity in BV2 microglial cells. Moreover, salidroside suppressed LPS-induced activation of nuclear factor kappa B (NF-kappa B) by blocking degradation of I kappa B alpha and phosphorylation of MAPK (p38, JNK, ERK1/2), which resulted in inhibition of chemokine expression. These results suggest that salidroside possesses a potent suppressive effect on cell migration of BV2 microglia and this compound may offer substantial therapeutic potential for treatment of ischemic strokes that are accompanied by microglial activation.
C1 [Hu, Haixia; Li, Zuanfang; Zhu, Xiaoqin; Lin, Ruhui] Fujian Univ Tradit Chinese Med, Biomed Res Ctr, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China.
   [Hu, Haixia; Li, Zuanfang; Zhu, Xiaoqin; Lin, Ruhui] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou 350108, Fujian, Peoples R China.
   [Chen, Lidian] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou 350108, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine
RP Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Coll Rehabil Med, 1 Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China.
EM cld@fjtcm.edu.cn
RI Chen, Lidian/GSN-6461-2022; Chen, Lidian/GSN-6461-2022
OI Chen, Lidian/0000-0002-8699-0839; Chen, Lidian/0000-0002-6454-7932
FU Natural Science Foundation of Fujian Province [2013J01335]; Research
   Project of Fujian University of Traditional Chinese Medicine [X2012010]
FX This study was supported by the Natural Science Foundation of Fujian
   Province (no. 2013J01335) and the Research Project of Fujian University
   of Traditional Chinese Medicine (no. X2012010).
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NR 17
TC 31
Z9 33
U1 1
U2 28
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 383821
DI 10.1155/2014/383821
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AG1EZ
UT WOS:000335159200001
PM 24864151
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Chen, HY
   Wu, MY
   Jin, CX
   Xing, SJ
   Feng, QQ
   Zhao, YJ
   Li, HL
   Jin, J
AF Chen, Haiyan
   Wu, Mingyang
   Jin, Chenxi
   Xing, Shengjie
   Feng, Qinqin
   Zhao, Yujie
   Li, Helei
   Jin, Jie
TI Ameliorative Effect of Salidroside on Chronic Fatigue Syndrome in Rats
   and the Underlying Mechanism
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE chronic fatigue syndrome; MEK1/2; ERK1/2; rats; salidroside
ID RHODIOLA-ROSEA; PATHWAY; SYSTEM
AB This study aimed to investigate the effect of salidroside on chronic fatigue syndrome (CFS) in rats and the underlying mechanism. Fifty SD rats were randomly divided into normal, model, and low-, middle- and high-dose salidroside groups, 10 rats in each group. The CFS model was established in later four groups. The later three groups were treated with 50, 100, and 200 mg/(kg.day) salidroside, respectively. After treatment, compared with model group, the CFS manifestations in salidroside groups were significantly alleviated. In addition, after treatment, compared with model group, in middle- and high-dose salidroside groups the body weight, exhausting swimming time and square-crossing number in salidroside groups were significantly increased (P < 0.01), the static tail-hanging time was significantly decreased (P < 0.01), and the skeletal muscle mitogen-activated protein kinase 1/2 (MEK1/2) and extracellular signal-regulated protein kinase (ERK1/2) contents were significantly increased (P < 0.01). In conclusion, salidroside can significantly ameliorate the CFS in rats. The mechanism may be related to its regulation of MEK/ERK signal pathway in skeletal muscle.
C1 [Chen, Haiyan] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Geriatr, Zhengzhou, Henan, Peoples R China.
   [Jin, Jie] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Encephalopathy, Zhengzhou, Henan, Peoples R China.
   [Wu, Mingyang] Henan Prov Hosp Tradit Chinese Med, Dept Tradit Chinese Med Inheritance Studio, Zhengzhou, Henan, Peoples R China.
   [Jin, Chenxi] Nanchang Univ, Queen Marys Sch, Nanchang, Jiangxi, Peoples R China.
   [Xing, Shengjie] Luoyang Orthoped Traumatol Hosp Henan Prov, Dept Neurorehabil, Luoyang, Peoples R China.
   [Feng, Qinqin] Shangqiu Cent Hosp, Dept Internal Med Neurol, Shangqiu, Peoples R China.
   [Zhao, Yujie] Henan Polytech Univ, Affiliated Hosp 1, Dept Rehabil Med, Jiaozuo, Henan, Peoples R China.
   [Li, Helei] Henan Univ, Zhengzhou Yihe Hosp, Dept Rehabil Med, Zhengzhou, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine; Nanchang University; Henan Polytechnic
   University; Henan University
RP Jin, J (corresponding author), Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Encephalopathy, Zhengzhou, Henan, Peoples R China.
EM jinjiezz8@163.com
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NR 20
TC 0
Z9 0
U1 0
U2 6
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2019
VL 38
IS 12
BP 2473
EP 2478
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KA1ZA
UT WOS:000505596400019
DA 2026-05-27
ER

PT J
AU Li, H
   Yang, T
   Wu, R
   Chen, TJ
   Sun, ZM
   Yang, L
AF Li, Hong
   Yang, Tian
   Wu, Rui
   Chen, Tianjun
   Sun, Zhongmin
   Yang, Lan
TI Salidroside inhibits platelet-derived growth factor-induced
   proliferation and migration of airway smooth muscle cells
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE airway remodeling; asthma; nuclear factor-kappa B pathway;
   platelet-derived growth factor; salidroside
ID FACTOR-KAPPA-B; MATRIX METALLOPROTEINASES; PHENOTYPE; ACTIVATION
AB Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) have been found to be important for the airway remodeling during the pathogenesis of asthma. Salidroside a bioactive glucoside that exerts antitumor activity via inhibiting the cell proliferation and migration of cancer cells. The aim of the current study was to evaluate the effects of salidroside on the proliferation and migration of ASMCs. Our results showed that salidroside inhibited the proliferation and migration of ASMCs in response to platelet-derived growth factor (PDGF) stimulation. Salidroside markedly attenuated the PDGF-induced production of matrix metalloproteinase 2 (MMP-2) and MMP-9 in ASMCs. The levels of contractile phenotype markers including smooth muscle alpha-actin and calponin were reduced in response to PDGF stimulation, which was attenuated by salidroside pretreatment. Salidroside diminished the increase in the expression levels of type I collagen and fibronectin in PDGF-stimulated ASMCs. Furthermore, salidroside blocked the PDGF-induced activation of the nuclear factor-kappa B (NF-kappa B) pathway in ASMCs. The results suggested that salidroside functionally regulated the proliferation, migration, phenotype plasticity, and extracellular matrix deposition in PDGF-induced ASMCs and the NF-kappa B pathway might be implicated in the effects of salidroside on ASMCs induced by PDGF.
C1 [Li, Hong; Yang, Tian; Wu, Rui; Chen, Tianjun; Sun, Zhongmin; Yang, Lan] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Yang, L (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
EM yang_lan6@126.com
RI Chen, tianjun/KDO-1849-2024
FU Basic Research of Natural Science Foundation of Shaanxi Province, China
   [2018JQ8040]
FX Basic Research of Natural Science Foundation of Shaanxi Province, China,
   Grant/Award Number: 2018JQ8040
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NR 24
TC 10
Z9 12
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD APR
PY 2019
VL 120
IS 4
BP 6642
EP 6650
DI 10.1002/jcb.27960
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HL8RK
UT WOS:000459010100185
PM 30552692
DA 2026-05-27
ER

PT J
AU Huang, XY
   Zou, LZ
   Yu, XM
   Chen, MY
   Guo, R
   Cai, H
   Yao, D
   Xu, XM
   Chen, YF
   Ding, C
   Cai, XD
   Wang, LX
AF Huang, Xiaoying
   Zou, Lizhen
   Yu, Xiaoming
   Chen, Mayun
   Guo, Rui
   Cai, Hui
   Yao, Dan
   Xu, Xiaomei
   Chen, Yanfan
   Ding, Cheng
   Cai, Xueding
   Wang, Liangxing
TI Salidroside attenuates chronic hypoxia-induced pulmonary hypertension
   via adenosine A2a receptor related mitochondria-dependent
   apoptosis pathway
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Salidroside; Pulmonary arterial hypertension; Chronic hypoxia; Adenosine
   A(2a) receptor; Apoptosis
ID SMOOTH-MUSCLE-CELLS; ARTERIAL-HYPERTENSION; RHODIOLA-ROSEA; MECHANISMS;
   CHANNEL
AB Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial remodeling mainly due to excess cellular proliferation and apoptosis resistance of pulmonary arterial smooth muscle cells (PASMCs). Salidroside, an active ingredient isolated from Rhodiola rosea is proposed to exert protective effects against PAH. However, the function of salidroside in PAH has not been investigated systematically and the underlying mechanisms are not clear. To investigate the effects of salidroside on PAH, the mice in chronic hypoxia model of PAH were given by an increasing concentration of salidroside (0, 16 mg/kg, 32 mg/kg, and 64 mg/kg). After salidroside treatment, the chronic hypoxia-induced right ventricular hypertrophy and pulmonary arterial remodeling were attenuated, suggesting a protective role played by salidroside in PAH. To explore the potential mechanisms, the apoptosis of PASMCs after salidroside treatment under hypoxia conditions were determined in vivo and in vitro, and also the mitochondria-dependent apoptosis factors, Bax, Bcl-2, cytochrome C, and caspase 9 were examined. The results revealed that salidroside reversed hypoxia-induced cell apoptosis resistance at least partially via a mitochondria-dependent pathway. In addition, salidroside upregulated the expression of adenosine A(2a) receptor (A(2a)R) in lung tissues of mice and in PASMCs in vitro after hypoxia exposure. Combined the evidence above, we conclude that salidroside can attenuate chronic hypoxia-induced PAH by promoting PASMCs apoptosis via an A2aR related mitochondria dependent pathway. (C) 2015 The Authors. Published by Elsevier Ltd.
C1 [Huang, Xiaoying; Zou, Lizhen; Yu, Xiaoming; Chen, Mayun; Guo, Rui; Cai, Hui; Yao, Dan; Xu, Xiaomei; Chen, Yanfan; Ding, Cheng; Cai, Xueding; Wang, Liangxing] Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Key Lab Heart & Lung, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Huang, XY (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Key Lab Heart & Lung, Wenzhou 325000, Zhejiang, Peoples R China.
EM drhuangxy@163.com; wzyxywlx@163.com
FU Chinese National Natural Science Foundation [81473406, 81470250,
   81270110]; Natural Science Foundation of Zhejiang Province Grants
   [LY13H010003]; Science and Technology Project of Wenzhou [Y20100190]
FX This study was supported by the Chinese National Natural Science
   Foundation Grants (No.81473406, 81470250, and 81270110), the Natural
   Science Foundation of Zhejiang Province Grants (LY13H010003), and
   Science and Technology Project of Wenzhou (No.Y20100190).
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NR 35
TC 90
Z9 96
U1 3
U2 46
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD MAY
PY 2015
VL 82
BP 153
EP 166
DI 10.1016/j.yjmcc.2015.03.005
PG 14
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA CH6KO
UT WOS:000354145700017
PM 25772255
OA hybrid
DA 2026-05-27
ER

PT J
AU Wang, MM
   Xiong, YJ
AF Wang, Miaomiao
   Xiong, Yujie
TI Salidroside alleviates atopic dermatitis-like responses by inhibiting
   MAPKs and NF-κB signaling pathways
SO ARCHIVES OF DERMATOLOGICAL RESEARCH
LA English
DT Article
DE Atopic dermatitis; Salidroside; Inflammation; MAPKs; NF-kappa B
ID INFLAMMATION; ACTIVATION; APOPTOSIS; PROTECTS; EXTRACT; CELLS; STAT1
AB Atopic dermatitis (AD) is a chronic inflammatory skin disease. Salidroside, a major component of Acer tegmentosum, may be a valuable candidate for developing anti-AD agents. In this study, we investigated the therapeutic roles of salidroside and its related mechanisms in AD. For in vivo experiments, male BALB/c mice were challenged with 2,4-dinitrochlorobenzene (DNCB) to induce AD-like lesions and orally administered with salidroside for AD-like manifestations were induced by DNCB. Histological changes were assessed via hematoxylin-eosin staining and toluidine blue staining. Scratching numbers and spleen weight were evaluated. For in vitro experiments, TNF-alpha/IFN-gamma-treated HaCaT cells and primary keratinocytes were used. Pro-inflammatory factors and pathway-associated proteins levels were measured by RT-qPCR and western blotting. Salidroside reduced the release of pro-inflammatory cytokines and chemokines in TNF-alpha/IFN-gamma-treated HaCaT cells and primary keratinocytes. Salidroside alleviated DNCB-induced AD-like symptoms in mice. Salidroside attenuated the DNCB-induced atopic skin inflammation in vivo. Mechanistically, salidroside inactivated MAPK and NF-kappa B pathways in vitro and in vivo. Salidroside ameliorates AD-like responses via inactivating the MAPK and NF-kappa B pathways.
C1 [Wang, Miaomiao] Bengbu Med Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Bengbu 233000, Peoples R China.
   [Xiong, Yujie] Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing 210029, Peoples R China.
   [Wang, Miaomiao] Bengbu Med Univ, Affiliated Hosp 1, 287 Changhuai Rd, Bengbu, Anhui, Peoples R China.
C3 Bengbu Medical University; Nanjing University of Chinese Medicine;
   Bengbu Medical University
RP Wang, MM (corresponding author), Bengbu Med Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Bengbu 233000, Peoples R China.; Wang, MM (corresponding author), Bengbu Med Univ, Affiliated Hosp 1, 287 Changhuai Rd, Bengbu, Anhui, Peoples R China.
EM wmmiao876@hotmail.com
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NR 57
TC 0
Z9 1
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-3696
EI 1432-069X
J9 ARCH DERMATOL RES
JI Arch. Dermatol. Res.
PD APR 1
PY 2025
VL 317
IS 1
AR 666
DI 10.1007/s00403-025-04091-4
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0ZL2N
UT WOS:001459678700004
PM 40167805
DA 2026-05-27
ER

PT J
AU Qin, XY
   Wang, H
   Li, Q
   Hu, DS
   Wang, LX
   Zhou, BY
   Liao, R
   Liu, YY
AF Qin, Xiaoyan
   Wang, Han
   Li, Qi
   Hu, Dingheng
   Wang, Liangxu
   Zhou, Baoyong
   Liao, Rui
   Liu, Yanyao
TI Salidroside ameliorates acute liver transplantation rejection in rats by
   inhibiting neutrophil extracellular trap formation
SO ACTA BIOCHIMICA ET BIOPHYSICA SINICA
LA English
DT Article
DE salidroside; neutrophil extracellular traps; acute rejection; liver
   transplantation; HMGB1
ID ISCHEMIA-REPERFUSION INJURY; PATHWAY
AB Acute rejection is an important factor affecting the survival of recipients after liver transplantation. Salidroside has various properties, including anti-inflammatory, antioxidant, and hepatoprotective properties. This study aims to investigate whether salidroside can prevent acute rejection after liver transplantation and to examine the underlying mechanisms involved. An in vivo acute rejection model is established in rats that are pretreated with tacrolimus (1 mg/kg/d) or salidroside (10 or 20 mg/kg/d) for seven days after liver transplantation. In addition, an in vitro experiment is performed using neutrophils incubated with salidroside (1, 10, 50 or 100 mu M). Hematoxylin-eosin staining, terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, immunosorbent assays, immunofluorescence analysis, Evans blue staining, and western blot analysis are performed to examine the impact of salidroside on NET formation and acute rejection in vitro and in vivo. We find that Salidroside treatment reduces pathological liver damage, serum aminotransferase level, and serum levels of IL-1 beta, IL-6, and TNF-alpha in vivo. The expressions of proteins associated with the HMGB1/TLR-4/MAPK signaling pathway (HMGB1, TLR-4, p-ERK1/2, pJNK, p-P38, cleaved caspase-3, cleaved caspase-9, Bcl-2, Bax, IL-1 beta, TNF-alpha, and IL-6) are also decreased after salidroside treatment. In vitro experiments show that the release of HMGB1/TLR-4/MAPK signaling pathway-associated proteins from neutrophils treated with lipopolysaccharide is decreased by salidroside. Moreover, salidroside inhibits NETosis and protects against acute rejection by regulating the HMGB1/TLR-4/MAPK signaling pathway. Furthermore, salidroside combined with tacrolimus has a better effect than either of the other treatments alone. In summary, salidroside can prevent acute liver rejection after liver transplantation by reducing neutrophil extracellular trap development through the HMGB1/TLR-4/MAPK signaling pathway.
C1 [Qin, Xiaoyan; Wang, Han; Li, Qi; Hu, Dingheng; Wang, Liangxu; Zhou, Baoyong; Liao, Rui; Liu, Yanyao] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing 400042, Peoples R China.
   [Qin, Xiaoyan] Chongqing Med Univ, Dept Gen Surg & Trauma Surg, Childrens Hosp,Key Lab Child Dev & Disorders, Natl Clin Res Ctr Child Hlth & Disorders,Minist E, Chongqing 400014, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Liu, YY (corresponding author), Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing 400042, Peoples R China.
EM Liuyanyao147@sina.com
RI zhou, yong/GSJ-3816-2022; Qin, Xiaoyan/KLZ-0501-2024; liu,
   yanyao/HMW-2633-2023; Liao, Rui/AAC-4332-2020; Li, Qi/GSM-8045-2022
FU National Natural Science Foundation of China [82300745]; China
   Postdoctoral Science Foundation [2023M730442]; Chongqing Postdoctoral
   Science Foundation [CSTB2023NSCQ-BHX0103]
FX This word was supported by the grants from the National Natural Science
   Foundation of China (No. 82300745 to Y.L.), the China Postdoctoral
   Science Foundation (No. 2023M730442 to Y.L.), and the Chongqing
   Postdoctoral Science Foundation (No. CSTB2023NSCQ-BHX0103 to Y.L.).
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NR 38
TC 4
Z9 4
U1 4
U2 18
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, 100009,
   PEOPLES R CHINA
SN 1672-9145
EI 1745-7270
J9 ACTA BIOCH BIOPH SIN
JI Acta Biochim. Biophys. Sin.
PD JUN
PY 2024
VL 56
IS 6
BP 833
EP 843
DI 10.3724/abbs.2024055
PG 11
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA XU8C0
UT WOS:001264271500002
PM 38716542
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, Q
   Zhou, XD
   Kolosov, VP
   Perelman, JM
AF Li, Qi
   Zhou, Xiang-Dong
   Kolosov, Victor P.
   Perelman, Juliy M.
TI Salidroside reduces cold-induced mucin production by inhibiting TRPM8
   activation
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE salidroside; mucin; airway; cold stimuli; transient receptor potential
   melastatin 8
ID EPITHELIAL-CELLS; PHENYLPROPANOID GLYCOSIDES; DOWN-REGULATION; CHANNEL
   TRPM8; IN-VITRO; RECEPTOR; CA2+; MENTHOL; CREB; DESENSITIZATION
AB Salidroside is an effective component of the traditional Chinese herb, Rhodiola rosea, that is known to have the ability to protect individuals from cold attacks. In the present study, we investigated the effects of salidroside on respiratory epithelial cells exposed to cold temperatures. We wished to determine whether salidroside exerts any effect on cold-induced mucin (MUC) production and the possible mechanisms involved in this process. We incubated HBE16 cells with salidroside, exposed them to a cold stimulus (18 degrees C), and assayed the following endpoints: MUC production (the expression of MUC5AC), concentration intracellular of free calcium ([Ca2+]i), the activation of the transient receptor potential melastatin 8 (TRPM8) channel and the cAMP response element-binding protein (CREB). Our results revealed a significant increase in the [Ca2+]i concentration, as well as in TRPM8 and CREB expression in the cold-stimulated cells. MUC5AC expression was also increased. Treatment of the cells with salidroside at concentrations of 50 and 100 mu M decreased the [Ca2+]i concentration, with a maximal effect detected in the cells treated with 100 mu M salidroside. The expression of TRPM8 and TRPM8 channel conductivity were also repressed by salidroside; salidroside decreased the high levels of CREB activity and phosphorylation observed in the cold-stimulated cells. Furthermore, we transfected the cold-stimulated cells with CREB small interfering RNA (siRNA) to analyze TRPM8 gene expression in the absence of CREB activity. The results revealed that the cells treated with either CREB siRNA or salidroside expressed low levels of TRPM8 mRNA and protein. These results indicate that salidroside reduces MUC overproduction induced by cold stimuli and that salidroside exerts its protective effects by inhibiting TRPM8 activation, mainly by decreasing CREB activity.
C1 [Li, Qi; Zhou, Xiang-Dong] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing 400010, Peoples R China.
   [Kolosov, Victor P.; Perelman, Juliy M.] Russian Acad Med Sci, Siberian Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Blagoveshchensk 675000, Russia.
C3 Chongqing Medical University; Russian Academy of Medical Sciences; Far
   Eastern Scientific Centre of Physiology and Pathology of Respiration,
   RAMS
RP Zhou, XD (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, 74 Linjiang Rd, Chongqing 400010, Peoples R China.
EM zxd999@263.net
RI Kolosov, Victor/AAO-4504-2020; /JBJ-1890-2023
OI Perelman, Juliy/0000-0002-9411-7474
FU National Nature Science Foundation of China [81100003, 31171346];
   China-Russia Cooperation Research Foundation [31211120168]; New Teacher
   Fund for Doctor Station; Ministry of Education, China [20115503120006];
   Chongqing Nature Science Foundation [cstc2011jjA10046]
FX The present study was supported by the National Nature Science
   Foundation of China (grant no. 81100003 and 31171346), and the
   China-Russia Cooperation Research Foundation (grant no. 31211120168),
   and the New Teacher Fund for Doctor Station, the Ministry of Education,
   China (no. 20115503120006), and Chongqing Nature Science Foundation
   (grant no. cstc2011jjA10046).
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NR 46
TC 10
Z9 17
U1 0
U2 19
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD SEP
PY 2013
VL 32
IS 3
BP 637
EP 646
DI 10.3892/ijmm.2013.1434
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 190VS
UT WOS:000322371000015
PM 23835496
OA Bronze
DA 2026-05-27
ER

PT J
AU Barhwal, K
   Das, SK
   Kumar, A
   Hota, SK
   Srivastava, RB
AF Barhwal, Kalpana
   Das, Saroj K.
   Kumar, Ashish
   Hota, Sunil K.
   Srivastava, Ravi B.
TI RETRACTED: Insulin receptor A and Sirtuin 1 synergistically improve
   learning and spatial memory following chronic salidroside treatment
   during hypoxia (Retracted article. See vol. 165, pg. 277, 2023)
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article; Retracted Publication
DE hypoxia; insulin receptor; memory; mitochondrial biogenesis;
   salidroside; Sirtuin 1
ID OXIDATIVE-STRESS; HYPOBARIC HYPOXIA; MITOCHONDRIAL BIOGENESIS;
   SKELETAL-MUSCLE; HIPPOCAMPAL-NEURONS; PROTEIN-KINASE; BRAIN; RAT;
   EXPRESSION; IMPAIRMENT
AB Hypoxia has been reported to cause hippocampal neurodegeneration resulting in learning and memory deficits. In the present study, we investigated the potential of salidroside, a glucoside derivative of tyrosol, in ameliorating hypoxia-induced neurodegeneration and memory impairment. Morris water maze test showed improvement in learning and spatial memory of salidroside-treated hypoxic rats correlating with increased dendritic intersections and arborization. Salidroside administration increased phosphorylation of insulin receptor subunit A (IRA) at Y972, Y1162/63, and Y1146 sites and subsequent activation of AMP-activated protein kinase (AMPK) subunit isoforms pAMPK1 and pAMPK2 resulting in mitochondrial biogenesis. Contrarily, silencing of IRA in salidroside-supplemented hypoxic hippocampal cells could not improve cell viability or alter pAMPK1 and pAMPK2 expression. Rats administered with salidroside showed elevated expression of phosphorylated cAMP response element-binding protein in the hippocampus. Salidroside administration also resulted in increased sirtuin 1 (SIRT1) activity through a cytochrome P4502E1 (CYP2E1)-regulated mechanism that was independent of pIRA. Taken together, these findings suggest a synergistic role of pIRA and SIRT1 in salidroside-mediated neuroprotection, mitochondrial biogenesis, and cognitive improvement during hypoxia.
C1 [Barhwal, Kalpana; Das, Saroj K.; Kumar, Ashish; Hota, Sunil K.; Srivastava, Ravi B.] Def Inst High Altitude Res, Leh Ladakh 901205, Jammu & Kashmir, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   High Altitude Research (DIHAR)
RP Hota, SK (corresponding author), Def Inst High Altitude Res, Neurosci & Expt Biol Div, 56 APO, Leh Ladakh 901205, Jammu & Kashmir, India.
EM drsunilhota@hotmail.com
RI /W-5452-2019
FU Science and Engineering Research Board [SB/FT/LS-01/2013]; Defence
   Research & Development Organization; Ministry of Defence, Govt of India;
   Department of Science & Technology, Govt of India
FX The present study was funded by Science and Engineering Research Board
   (SB/FT/LS-01/2013), Defence Research & Development Organization,
   Ministry of Defence, Govt of India and Department of Science &
   Technology, Govt of India. The authors declare no conflicts of
   interests.
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NR 66
TC 47
Z9 52
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2015
VL 135
IS 2
BP 332
EP 346
DI 10.1111/jnc.13225
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CT5DP
UT WOS:000362828200012
PM 26173704
OA Bronze
DA 2026-05-27
ER

PT J
AU Hu, CH
   Xiang, S
   Li, LC
   Qin, FX
   Wei, GL
   Huang, XF
   Ding, R
   Huo, JG
   Fang, ZJ
AF Hu, Canhong
   Xiang, Shao
   Li, Lingchang
   Qin, FengXia
   Wei, Guoli
   Huang, Xiaofei
   Ding, Rong
   Huo, Jiege
   Fang, Zhijun
TI Salidroside Induces Apoptosis and Autophagy in Gastric Cancer Cells via
   Regulation of Mitogen-Activated Protein Kinases Signaling Pathway
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article
DE Apoptosis; autophagy; gastric cancer; mitogen-activated protein kinase;
   salidroside
AB Background: Salidroside, an active ingredient of Rhodiola rosea, exhibits antiproliferative effect in gastric cancer (GC) cells. However, the involvement of salidroside in apoptosis and autophagy of GC cells has not been elucidated. Materials and Methods: Cell viability of BGC-823 cells was assessed by CCK-8 assay, and apoptosis was analyzed with terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling assay and flow cytometry. The apoptosis- and autophagy-associated proteins and mitogen-activated protein kinases (MAPKs) were determined by Western blot analysis. Autophagy was evaluated by green fluorescent protein-fused LC3 punctate formation. Results: Salidroside inhibited proliferation and promoted apoptosis and autophagy of BGC-823 cells in a dose-dependent manner. In addition, salidroside enhanced the phosphorylation of p38 MAPK, ERK1/2, and JNK. Furthermore, inhibition of MAPKs significantly abolished the effects of salidroside in BGC-823 cells. Conclusion: Salidroside induced apoptosis and autophagy of BGC-823 cells via activation of MAPK signaling pathway.
C1 [Hu, Canhong; Li, Lingchang; Qin, FengXia; Wei, Guoli; Huang, Xiaofei; Ding, Rong; Huo, Jiege; Fang, Zhijun] Nanjing Univ Chinese Med, Dept Oncol, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210046, Jiangsu, Peoples R China.
   [Hu, Canhong; Li, Lingchang; Qin, FengXia; Wei, Guoli; Huang, Xiaofei; Ding, Rong; Huo, Jiege; Fang, Zhijun] Jiangsu Prov Acad Tradit Chinese Med, Dept Oncol, Nanjing 210046, Jiangsu, Peoples R China.
   [Xiang, Shao] Nanjing Univ Chinese Med, Grad Sch, Nanjing 210046, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Huo, JG (corresponding author), Nanjing Univ Chinese Med, Dept Oncol, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210046, Jiangsu, Peoples R China.; Fang, ZJ (corresponding author), Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Peoples R China.
EM huojiege@sina.com; fangzjnj65@sina.com
RI Li, Lingchang/AAL-4850-2021; huo, jiege/HKM-3928-2023
FU Youth fund of Jiangsu Natural Science Foundation [BK20161080]; Jiangsu
   Leading Talents Project of Traditional Chinese Medicine [SLJ0211]
FX This work was supported by the Youth fund of Jiangsu Natural Science
   Foundation (No. BK20161080) and Jiangsu Leading Talents Project of
   Traditional Chinese Medicine (No. SLJ0211).
CR Afasizheva A, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2211-7
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NR 23
TC 1
Z9 1
U1 0
U2 19
PU SAGE PUBLICATIONS INDIA  PVT LTD
PI NEW DELHI
PA B-1-I-1 MOHAN CO-OPERATIVE INDUSTRIAL AREA, MATHURA RD, POST BAG NO 7,
   NEW DELHI 110 044, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD JAN-MAR
PY 2021
VL 17
IS 73
BP 179
EP 185
DI 10.4103/pm.pm_119_20
PG 7
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TF3AZ
UT WOS:000670584400025
DA 2026-05-27
ER

PT J
AU Han, F
   Li, YT
   Mao, XJ
   Zhang, XS
   Guan, J
   Song, AH
   Yin, R
AF Han, Fei
   Li, Yan-ting
   Mao, Xin-juan
   Zhang, Xiao-shu
   Guan, Jiao
   Song, Ai-hua
   Yin, Ran
TI Metabolic profile of salidroside in rats using high-performance liquid
   chromatography combined with Fourier transform ion cyclotron resonance
   mass spectrometry
SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY
LA English
DT Article
DE Salidroside; HPLC-FT-ICR MS; Metabolism
ID IDENTIFICATION; MS; ACID
AB A high-performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FT-ICR MS) method was developed to study the in vivo metabolism of salidroside for the first time. Plasma, urine, bile, and feces samples were collected from male rats after a single intragastric gavage of salidroside at a dose of 50 mg/kg. Besides the parent drug, a total of seven metabolites (three phase I and four phase II metabolites) were detected and tentatively identified by comparing their mass spectrometry profiles with those of salidroside. Results indicated that metabolic pathways of salidroside in male rats included hydroxylation, dehydrogenation, glucuronidation, and sulfate conjugation. Among them, glucuronidation and sulfate conjugation were the major metabolic reactions. And most important, the detection of the sulfation metabolite of p-tyrosol provides a clue for whether the deglycosylation of salidroside occurs in vivo after intragastric gavage. In summary, results obtained in this study may contribute to the better understanding of the safety and mechanism of action of salidroside.
C1 [Han, Fei; Li, Yan-ting; Mao, Xin-juan; Zhang, Xiao-shu; Guan, Jiao; Song, Ai-hua; Yin, Ran] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China.
C3 Shenyang Pharmaceutical University
RP Song, AH; Yin, R (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China.
EM songaihua62630@163.com; yinran_syspu@163.com
FU Education Department of Liaoning Province of China [2014380]; National
   Health and Medical Research Council (NHMRC) [2014380] Funding Source:
   National Health and Medical Research Council (NHMRC)
FX This work was supported by the Education Department of Liaoning Province
   of China (No. 2014380).
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PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1618-2642
EI 1618-2650
J9 ANAL BIOANAL CHEM
JI Anal. Bioanal. Chem.
PD MAR
PY 2016
VL 408
IS 7
BP 1975
EP 1981
DI 10.1007/s00216-015-9080-9
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DE7FU
UT WOS:000370801900025
PM 26558763
DA 2026-05-27
ER

PT J
AU Yang, LM
   Zhou, L
   Wang, XH
   Wang, W
   Wang, J
AF Yang, Limin
   Zhou, Lin
   Wang, Xiaohui
   Wang, Wang
   Wang, Jin
TI Inhibition of HMGB1 involved in the protective of salidroside on liver
   injury in diabetes mice
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Diabetes; HMGB1; Liver inflammation
ID NLRP3 INFLAMMASOME ACTIVATION; INDUCED INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; FATTY LIVER; OBESITY; RAGE; RECEPTOR; CELLS; MAPK;
   ADIPOCYTES
AB High mobility group box 1 (HMGB1) is a nuclear protein that is released on injury triggers inflammation. This study aims to elucidate the effects of salidroside on diabetes-induced liver inflammation. The levels of glucose, inflammatory cytokines and hepatic functional parameters in serum and liver of type 2 diabetic db/db mice were examined. Immunohistochemistry, immunofluorescence and western blot tests were performed to determine the mechanisms underlying the action. Palmitic acid (PA) or HMGB1-stimulated was adopted as an in vitro cell model. Salidroside treatment improved glucose tolerance, lipid profiles while decreased the production of inflammatory cytokines. It also reduced the levels of serum biochemical markers. In addition, salidroside inhibited HMGB1 signaling pathway in db/db mice. In the salidroside treatment significantly inhibited PA or HMGB1 induced inflammatory signaling pathway, too. HMGB1 inhibitors and HMGB1 knockdown both hindered PA induced HMGB1 signaling pathway, showing the same effect as salidroside. Salidroside treatment significantly alleviates insulin resistance, hyperglycemia and hepatic inflammation in db/db mice, and also showed beneficial to PA-stimulated. Salidroside proves to control hyperglycemia and hepatic inflammation via inhibiting HMGB1/ RAGE/NF-kappa B and HMGB1/TLR4/NLRP3 signaling pathways.y
C1 [Yang, Limin; Wang, Jin] Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
   [Zhou, Lin] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
   [Wang, Xiaohui] Zhengzhou Univ, Affiliated Hosp 1, Dept Ultrasonog, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
   [Wang, Wang] Zhengzhou Univ, Sch Basic Med Sci, Dept Physiol & Neurobiol, Zhengzhou 450001, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University;
   Zhengzhou University
RP Wang, J (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
EM yanglimin19840814@163.com; fcczhoul@zzu.edu.cn; xhhyykl@126.com;
   zzuwwuzz@163.com; zwj834@126.com
RI Yang, Limin/PVD-6402-2026
FU National Natural Science Foundation of China [81400800]
FX This research was supported by National Natural Science Foundation of
   China (81400800).
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NR 41
TC 22
Z9 24
U1 2
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC
PY 2020
VL 89
AR 106987
DI 10.1016/j.intimp.2020.106987
PN A
PG 14
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA PF2MR
UT WOS:000598895600003
PM 33217691
DA 2026-05-27
ER

PT J
AU Lu, H
   Li, Y
   Zhang, T
   Liu, MD
   Chi, YQ
   Liu, SX
   Shi, YH
AF Lu, Hua
   Li, Ying
   Zhang, Tao
   Liu, Maodong
   Chi, Yanqing
   Liu, Shuxia
   Shi, Yonghong
TI Salidroside Reduces High-Glucose-Induced Podocyte Apoptosis and
   Oxidative Stress via Upregulating Heme Oxygenase-1 (HO-1) Expression
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Apoptosis; Heme Oxygenase-1; Reactive Oxygen Species
ID MAPK SIGNALING PATHWAYS; PC12 CELLS; ACTIVATION; INJURY; INDUCTION;
   MECHANISM; KINASE; LIVER; MICE; CARDIOMYOCYTES
AB Background: Hyperglycemia is one of the most dangerous factors causing diabetic nephropathy. Salidroside is considered to have the effects of reducing oxidative stress damage and improving cell viability. This study was performed to investigate whether and how salidroside reduces high-glucose (HG)-induced apoptosis in mouse podocytes.
   Material/Methods: We examined whether salidroside could decrease HG-induced podocyte oxidative stress and podocyte apoptosis in vitro. The potential signaling pathways were also investigated. Podocytes (immortalized mouse epithelial cells) were treated with normal glucose (5.5 mM) as control or HG (30 mM), and then exposed to salidroside treatment.
   Results: HG enhanced the generation of intracellular reactive oxygen species (ROS) and apoptosis in podocytes. Salidroside reduced HG-induced apoptosis-related consequences via promoting HO-1 expression. Salidroside increased the expression level of phosphorylated Akt (p-Akt) and phosphorylated ILK (p-ILK), p-JNK, and p-ERK and localization of Nrf-2. JNK inhibitor and ILK inhibitor decreased HO-1 expression to different degrees. Moreover, specific siRNAs of ILK, Nrf-2, and HO-1, and inhibitors of HO-1 and ILK significantly increased ROS generation and Caspase9/3 expression in the presence of salidroside and HG.
   Conclusions: The results suggest that salidroside reduces HG-induced ROS generation and apoptosis and improves podocytes viability by upregulating HO-1 expression. ILK/Akt, JNK, ERK1/2, p38 MAPK, and Nrf-2 are involved in salidroside-decreased podocyte apoptosis in HG condition.
C1 [Lu, Hua; Li, Ying; Zhang, Tao; Liu, Maodong; Chi, Yanqing] Hebei Med Univ, Hosp 3, Dept Nephrol, Shijiazhuang, Hebei, Peoples R China.
   [Lu, Hua; Li, Ying; Zhang, Tao; Liu, Maodong; Chi, Yanqing; Liu, Shuxia; Shi, Yonghong] Key Lab Kidney Dis Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Shuxia; Shi, Yonghong] Hebei Med Univ, Dept Pathol, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Li, Y (corresponding author), Hebei Med Univ, Hosp 3, Dept Nephrol, Shijiazhuang, Hebei, Peoples R China.; Li, Y (corresponding author), Key Lab Kidney Dis Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
EM liyingly75@163.com
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PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD AUG 23
PY 2017
VL 23
DI 10.12659/MSM.902806
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF8HB
UT WOS:000409256300001
PM 28831032
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Torrens-Spence, MP
   Pluskal, T
   Li, FS
   Carballo, V
   Weng, JK
AF Torrens-Spence, Michael P.
   Pluskal, Tomas
   Li, Fu-Shuang
   Carballo, Valentina
   Weng, Jing-Ke
TI Complete Pathway Elucidation and Heterologous Reconstitution of
   Rhodiola Salidroside Biosynthesis
SO MOLECULAR PLANT
LA English
DT Article
DE salidroside; icariside D2; 4-hydroxyphenylacetaldehyde; tyrosol;
   aromatic acetaldehyde synthesis; aromatic amino acid decarboxylase
ID MOLECULAR-CLONING; TYROSINE DECARBOXYLASE; BIOCHEMICAL EVALUATION;
   PLANT; METABOLISM; SEQUENCE; SYNTHASE; ROSEA; GENE; EXPRESSION
AB Salidroside is a bioactive tyrosine-derived phenolic natural product found in medicinal plants under the Rhodiola genus. In addition to their anti-fatigue and anti-anoxia roles in traditional medicine, Rhodiola total extract and salidroside have also displayed medicinal properties as anti-cardiovascular diseases and anticancer agents. The resulting surge in global demand of Rhodiola plants and salidroside has driven some species close to extinction. Here, we report the full elucidation of the Rhodiola salidroside biosynthetic pathway utilizing the first comprehensive transcriptomics and metabolomics datasets for Rhodiola rosea. Unlike the previously proposed pathway involving separate decarboxylation and deamination enzymatic steps from tyrosine to the key intermediate 4-hydroxyphenylacetaldehyde (4-HPAA), Rhodiola contains a pyridoxal phosphate-dependent 4-HPAA synthase that directly converts tyrosine to 4-HPAA. We further identified genes encoding the subsequent 4-HPAA reductase and tyrosol: UDP-glucose8-O-gluco-syltransferase, respectively, to complete salidroside biosynthesis in Rhodiola. We show that heterologous production of salidroside can be achieved in the yeast Saccharomyces cerevisiae as well as the plant Nicotiana benthamiana through transgenic expression of Rhodiola salidroside biosynthetic genes. This study provides new tools for engineering sustainable production of salidroside in heterologous hosts.
EM wengj@wi.mit.edu
RI Weng, Jing-Ke/V-5934-2019; /C-7679-2019; Pluskal, Tomáš/C-6247-2012
OI Pluskal, Tomáš/0000-0002-6940-3006
FU Pew Scholar Program in the Biomedical Sciences [27345]; Searle Scholars
   Program [15-SSP-162]
FX This work was supported by the Pew Scholar Program in the Biomedical
   Sciences (J.-K.W.; Grant # 27345) and the Searle Scholars Program
   (J.K.W.; Grant 15-SSP-162).
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NR 71
TC 135
Z9 155
U1 16
U2 242
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1674-2052
EI 1752-9867
J9 MOL PLANT
JI Mol. Plant.
PD JAN 8
PY 2018
VL 11
IS 1
BP 205
EP 217
DI 10.1016/j.molp.2017.12.007
PG 13
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA FS0ML
UT WOS:000419468100016
PM 29277428
OA Bronze
DA 2026-05-27
ER

PT J
AU Sun, T
   Yang, JY
   Lu, LL
AF Sun, Tong
   Yang, Jingyi
   Lu, Lili
TI Salidroside Improves Antibiotic-Induced Gut Microbiota Disturbance and
   Low Levels of Short-Chain Fatty Acids in Mice
SO FOODS
LA English
DT Article
DE salidroside; antibiotics; gut microbiota; short-chain fatty acids;
   prebiotics
ID CEFTRIAXONE; HEALTH; EMERGENCE
AB Salidroside is the main active constituent of the functional food Rhodiola rosea and has a wide range of biological activities. This work investigated the regulation of salidroside with different doses and durations on the gut microbiota disturbance resulting from excessive injection of antibiotics in mice C57BL/6J. The salidroside treatment attenuated antibiotic-induced intestinal damage and reduced the levels of inflammation factors such as TNF alpha and IL-6. Importantly, salidroside promoted the recovery of gut microbiota richness, diversity, and community structure in mice. The intake of salidroside increased the abundance of beneficial bacteria represented by Lactobacillus and Bifidobacterium, and reduced the portion of disease-related bacteria, thus reshaping the structure and composition of gut microbiota. Moreover, after ingesting salidroside, the contents of short-chain fatty acids (SCFAs) increased, which could also facilitate the recovery of intestinal barrier functions. Low-dose salidroside plays an especially superiorly beneficial role in promoting the proliferation of probiotics and the production of SCFAs in a short time. These findings suggested that salidroside had similar beneficial functions of prebiotics and thus intake of it might be a new promising food therapy for improving antibiotic-induced gut microbiota disturbance.
C1 [Sun, Tong; Yang, Jingyi; Lu, Lili] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology
RP Lu, LL (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China.
EM lililu@hust.edu.cn
RI Yang, Jingyi/KYP-1286-2024
FU National Natural Science Foundation of China [21877044, 32071473]
FX This researchwas funded by National Natural Science Foundation of China
   (No. 21877044, and No. 32071473).
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NR 53
TC 12
Z9 13
U1 3
U2 46
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD OCT
PY 2022
VL 11
IS 19
AR 3073
DI 10.3390/foods11193073
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5H9WN
UT WOS:000868020800001
PM 36230149
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Feng, YB
   Zhao, XJ
   Lv, F
   Zhang, JQ
   Deng, BH
   Zhao, YH
   Hu, YL
   Wang, DY
   Liu, JG
   Lu, Y
   Bo, RN
   Liu, ZG
AF Feng, Yibo
   Zhao, Xiaojuan
   Lv, Fang
   Zhang, Jinqiu
   Deng, Bihua
   Zhao, Yanhong
   Hu, Yuanliang
   Wang, Deyun
   Liu, Jiaguo
   Lu, Yu
   Bo, Ruonan
   Liu, Zhenguang
TI Optimization on Preparation Conditions of Salidroside Liposome and Its
   Immunological Activity on PCV-2 in Mice
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID PORCINE CIRCOVIRUS TYPE-2; POLYSACCHARIDES; FORMULATION; EXTRACTION;
   STABILITY; DESIGN
AB The aim of this study was to optimize the preparation conditions of salidroside liposome with high encapsulation efficiency (EE) and to study the immunological enhancement activity of salidroside liposome as porcine circovirus type 2 virus (PCV-2) vaccine adjuvant. Response surface methodology (RSM) was selected to optimize the conditions for the preparation of salidroside liposome using Design-Expert V8.0.6 software. Three kinds of salidroside liposome adjuvants were prepared to study their adjuvant activity. BALB/c mice were immunized with PCV-2 encapsulated in different kinds of salidroside liposome adjuvants. The PCV-2-specific IgG in immunized mice serum was determined with ELISA. The results showed that when the concentration of ammonium sulfate was 0.26mol.L-1, ethanol volume 6.5 mL, temperature 43 degrees C, ethanol injection rate 3mL.min(-1), and salidroside liposome could be prepared with high encapsulation efficiency of 94.527%. Salidroside liposome as adjuvant could rapidly induce the production of PCV-2-specific IgG and salidroside liposome I adjuvant proved to provide the best effect among the three kinds of salidroside liposome adjuvants.
C1 [Feng, Yibo; Hu, Yuanliang; Wang, Deyun; Liu, Jiaguo; Bo, Ruonan; Liu, Zhenguang] Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China.
   [Zhao, Xiaojuan; Lv, Fang; Zhang, Jinqiu; Deng, Bihua; Zhao, Yanhong; Lu, Yu] Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Peoples R China.
C3 Nanjing Agricultural University; Jiangsu Academy of Agricultural
   Sciences
RP Wang, DY (corresponding author), Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China.
EM dywang@njau.edu.cn; luyu_nj@163.com
FU National Natural Science Foundation of China [31372472]; Special Fund
   for Agroscientific Research in the Public Interest [201303046,
   201403051]; Independent Innovation of Agricultural Sciences Program of
   Jiangsu Province [CX(13)3067]; Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD)
FX The project was supported by the National Natural Science Foundation of
   China (Grant no. 31372472), Special Fund for Agroscientific Research in
   the Public Interest (Grant no. 201303046, 201403051), Independent
   Innovation of Agricultural Sciences Program of Jiangsu Province
   (CX(13)3067), and Project Funded by the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD). The authors
   are grateful to all other staff at the Institute of Traditional Chinese
   Veterinary Medicine of Nanjing Agricultural University for their
   assistance in the experiments.
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NR 26
TC 11
Z9 13
U1 6
U2 82
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2015
VL 2015
AR 178128
DI 10.1155/2015/178128
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CH8VG
UT WOS:000354313600001
PM 25878712
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Du, XF
   Feng, WY
   Zhang, SH
   Lin, X
   Song, LH
   Shen, N
   Yang, XX
AF Du, Xinfang
   Feng, Wenying
   Zhang, Suhua
   Lin, Xian
   Song, Lihua
   Shen, Na
   Yang, Xiaoxiao
TI Salidroside attenuates LPS-induced inflammatory activation in young rats
   with acute lung injury via PI3K/Akt signaling pathway
SO CELLULAR AND MOLECULAR BIOLOGY
LA English
DT Article
DE Salidroside; PI3K; AKT signaling pathway; LPS; acute lung injury;
   inflammatory activation
AB This experiment aimed to analyze the salidroside effect on lipopolysaccharide (LPS)-induced inflammatory activation in young rats with acute lung injury (ALI) via PI3K/Akt signaling pathway. In this study, sixty SD young rats were divided into 5 groups (control, model, salidroside low-dose, salidroside medium-dose and salidroside high-dose), with 12 rats in each group. ALI rat model was established. In the control and model group, rats were intraperitoneally injected with normal saline, while the salidroside low-, medium-, and high -dose groups were intraperitoneally injected with 5, 20, and 40 mg/kg salidroside, then the pathological changes of lung tissue, lung injury score, wet/dry lung weight ratio, neutrophils and TNF-& alpha;, MPO, MDA, NO, p-PI3K and p-AKT were detached and compared between these groups. Results showed that the ALI rat model was successfully established. The lung injury score, wet/dry lung weight ratio, neutrophils and TNF-& alpha; in alveolar lavage fluid, MPO, MDA, NO, p-PI3K and p-AKT in the lung tissue of the model group were increased than the control group. With the increase of salidroside dose, lung injury score, wet lung weight/dry lung weight ratio, neutrophils and TNF-& alpha; in alveolar lavage fluid, and the levels of MPO, MDA, NO, p-PI3K and p-AKT in lung tissues of the salidroside group were decreased then model group (P < 0.05). In conclusion, salidroside may reduce the activation of inflammatory cells in the lung tissue of young rats with LPS-induced ALI by activating PI3K/AKT signaling pathway, thereby exerting a certain protective effect on the lung tissue with LPS-induced ALI.
C1 [Du, Xinfang; Zhang, Suhua] Hebei Engn Univ, Dept Resp & Crit Care 1, Affiliated Hosp, Handan 056000, Hebei, Peoples R China.
   [Feng, Wenying] Hebei Engn Univ, Dept Resp & Crit Care 2, Affiliated Hosp, Handan 056000, Hebei, Peoples R China.
   [Lin, Xian] Hebei Engn Univ, Dept Geratol, Affiliated Hosp, Handan 056000, Hebei, Peoples R China.
   [Song, Lihua] Hebei Engn Univ, Dept Cardiol, Affiliated Hosp, Handan 056000, Hebei, Peoples R China.
   [Shen, Na] Hebei Engn Univ, Dept Hemopathol, Affiliated Hosp, Handan 056000, Hebei, Peoples R China.
   [Yang, Xiaoxiao] Wuhan Univ, Inst Hepatobiliary Dis, Transplant Ctr, Natl Qual Control Ctr Donated Organ Procurement,Zh, Wuhan 430071, Hubei, Peoples R China.
C3 Hebei University of Engineering; Hebei University of Engineering; Hebei
   University of Engineering; Hebei University of Engineering; Hebei
   University of Engineering; Wuhan University
RP Yang, XX (corresponding author), Wuhan Univ, Inst Hepatobiliary Dis, Transplant Ctr, Natl Qual Control Ctr Donated Organ Procurement,Zh, Wuhan 430071, Hubei, Peoples R China.
EM fuaopo3759617923@163.com
RI Song, Lihua/GQA-3133-2022
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NR 15
TC 8
Z9 11
U1 4
U2 23
PU C M B  ASSOC
PI POITIERS
PA 34 BOULEVARD SOLFERINO, 86000 POITIERS, FRANCE
SN 0145-5680
EI 1165-158X
J9 CELL MOL BIOL
JI Cell. Mol. Biol.
PY 2023
VL 69
IS 3
BP 124
EP 128
DI 10.14715/cmb/2023.69.3.17
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA K5YH4
UT WOS:001017190100017
PM 37300679
OA hybrid
DA 2026-05-27
ER

PT J
AU Zhao, C
   Chen, ZW
   Zheng, JJ
AF Zhao, Chao
   Chen, Zhiwei
   Zheng, Jianjun
TI Salidroside Ester Prevents Apoptosis of Neurons through Suppression of
   Aβ-Accumulation and Down-regulation of Inflammatory Response in
   Alzheimer's Disease
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE anti-apoptotic; anti-inflammatory; beta-amyloid; chemotherapy; natural
   product; neurodegenerative disorder; salidroside ester
ID NITRIC-OXIDE SYNTHASE; NEUROPROTECTION; ACTIVATION; INDUCTION; PEPTIDE
AB The present study investigated salidroside ester, a relatively less polar derivative of salidroside in vitro for prevention of beta-amyloid induced damage in PC12 neuronal cells. Pretreatment of PC12 cells with salidroside ester (0.12 to 32 mu M) reversed beta-amyloid mediated reduction in viability in dose-dependent manner. The beta-amyloid mediated reduction of PC12 cell viability was completely prevented by salidroside ester treatment at 32 mu M. The beta-amyloid induced up-regulation of PGE2 expression in PC12 cells was significantly (p < 0.05) alleviated by salidroside ester pre-treatment. Salidroside ester pre-treatment also alleviated beta-amyloid induced up-regulation of COX-2 expression and NO production significantly (p <0.05) in PC12 cells. Moreover, beta-amyloid induced up-regulation of iNOS expression in PC12 cells was significantly (p < 0.05) alleviated by salidroside ester pre-treatment. Additionally, salidroside ester pre-treatment significantly (p < 0.05) inhibited beta-amyloid mediated up-regulation of NF-xB nuclear translocation in PC12 cells. Thus, salidroside ester prevents loss of PC12 cells induced by beta-amyloid stimulation through anti-inflammatory mechanism. Moreover, its pretreatment targets beta-amyloid induced increase in PGE2 and COX-2 expression and down-regulated iNOS and NO level in PC12 cells. Therefore, salidroside ester needs to be investigated further for possible role in prevention of neurodegenerative disorders such as Alzheimer's disease.
C1 [Zhao, Chao; Chen, Zhiwei; Zheng, Jianjun] Shangrao Municipal Hosp, Neurol Dept, Shangrao City 334000, Jiangxi, Peoples R China.
RP Zhao, C (corresponding author), Shangrao Municipal Hosp, Neurol Dept, Shangrao City 334000, Jiangxi, Peoples R China.
EM zc45357665@163.com
RI jianjun, zheng/GXF-5739-2022
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U2 7
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2022
VL 41
IS 3
BP 682
EP 687
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZN2WE
UT WOS:000764900200023
DA 2026-05-27
ER

PT J
AU Li, YZ
   Wu, AP
   Wang, DD
   Yang, PP
   Sheng, B
AF Li, Ying-Zhi
   Wu, Ai-Ping
   Wang, Dan-Dan
   Yang, Pan-Pan
   Sheng, Bin
TI Salidroside attenuates oxygen and glucose deprivation-induced neuronal
   injury by inhibiting ferroptosis
SO ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
LA English
DT Article
DE Salidroside; Rhodiola rosea; Ferroptosis; Oxygen and glucose
   deprivation; Neuronal differentiation; Ischemic stroke
ID ACUTE ISCHEMIC-STROKE; INTRAVENOUS THROMBOLYSIS; CELL
AB Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation (OGD)-treated NT2 cells and its underlying mechanisms of action.Methods: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGD-treated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of salidroside.Results: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of salidroside.Conclusions: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.
C1 [Li, Ying-Zhi; Wu, Ai-Ping; Wang, Dan-Dan; Yang, Pan-Pan] Zhejiang Hosp, Dept Rehabil Med, Hangzhou 310007, Zhejiang, Peoples R China.
   [Sheng, Bin] Zhejiang Prov Peoples Hosp, Dept Emergency Med, Hangzhou 310014, Zhejiang, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital
RP Sheng, B (corresponding author), Zhejiang Prov Peoples Hosp, Dept Emergency Med, Hangzhou 310014, Zhejiang, Peoples R China.
EM Shengbin0203@163.com
RI Li, yingzhi/OYE-0854-2025; pan, yang/JSL-1184-2023
FU Zhejiang Traditional Chinese Medicine Science and Technology Plan
   Project [2021ZB027, 2023ZL267]; Zhejiang Medical and Health Platform
   Project of China [2019KY002, 2019RC092]
FX This study was supported by the Zhejiang Traditional Chinese Medicine
   Science and Technology Plan Project (2021ZB027, 2023ZL267) and Zhejiang
   Medical and Health Platform Project of China (2019KY002, 2019RC092).
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NR 45
TC 2
Z9 3
U1 3
U2 27
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2221-1691
EI 2588-9222
J9 ASIAN PAC J TROP BIO
JI Asian Pac. Trop. Biomed.
PD FEB
PY 2023
VL 13
IS 2
BP 70
EP 79
DI 10.4103/2221-1691.369611
PG 10
WC Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Tropical Medicine
GA 9V6SV
UT WOS:000948521100003
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, XC
   Tang, YL
   Zeng, JL
   Qin, JB
   Lin, M
   Chen, M
   Liao, ZH
   Lan, XZ
AF Liu, Xuechao
   Tang, Yueli
   Zeng, Junlan
   Qin, Jianbo
   Lin, Min
   Chen, Min
   Liao, Zhihua
   Lan, Xiaozhong
TI Biochemical characterization of tyrosine aminotransferase and
   enhancement of salidroside production by suppressing tyrosine
   aminotransferase in Rhodiola crenulata
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Salidroside; Tyrosine aminotransferase; 4-Hydroxyphenylpyruvate;
   Tyrosol; Metabolic engineering
ID MOLECULAR-CLONING; GENE; BIOSYNTHESIS; ROOT
AB Rhodiola crenulata is a traditional Tibetan medicinal plant mainly distributed in high altitude areas of Tibet. As the main extract of R. crenulata, salidroside has important medicinal activities in enhancing the body's immunity and resisting microwave radiation by influencing cell metabolism. Tyrosine is the starting amino acid precursor for salidroside biosynthesis. As an aromatic amino acid, tyrosine participates not only in salidroside biosynthesis, but also in other metabolite biosynthesis which might compete against salidroside biosynthetic pathway. In this study, we functionally identified a tyrosine aminotransferase in R. crenulata (RcTAT) that could convert tyrosine into 4-hydroxyphenylpyruvate (4-HPP). The Km and Vmax values of RcTAT for tyrosine were respectively 0.21 mM and 0.17 mu mol/min.mg under 9.0 pH and 39 degrees C. RNAi-mediated suppression of RcTAT expression markedly increased salidroside production in hairy root culture of R. crenulata. In summary, RcTAT is a key gene involved in the metabolic pathway that competes against salidroside biosynthesis, and suppressing its expression is a promising way to elevate salidroside production in planta.
C1 [Liu, Xuechao; Tang, Yueli; Zeng, Junlan; Liao, Zhihua; Lan, Xiaozhong] Southwest Univ, Sch Life Sci, Prov & Ministerial Cofounded Collaborat Innovat C, Chongqing 400715, Peoples R China.
   [Qin, Jianbo] Chongqing Acad Sci & Technol, Chongqing 401123, Peoples R China.
   [Lin, Min] Southwest Univ, Chinese Acad Agr Sci, Citrus Res Inst, Chongqing 400712, Peoples R China.
   [Chen, Min] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China.
   [Lan, Xiaozhong] Tibet Agr & Anim Husb Univ, Food Sci Coll, Prov & Ministerial Cofounded Collaborat Innovat C, Nyingchi 860000, Peoples R China.
C3 Southwest University - China; Chongqing Academy of Science & Technology;
   Southwest University - China; Chinese Academy of Agricultural Sciences;
   Southwest University - China; Xizang Agricultural & Animal Husbandry
   University
RP Liao, ZH; Lan, XZ (corresponding author), Southwest Univ, Sch Life Sci, Prov & Ministerial Cofounded Collaborat Innovat C, Chongqing 400715, Peoples R China.
EM zhliao@swu.edu.cn; lanxiaozhong@163.com
RI Zeng, Junlan/KFA-6761-2024
OI Liao, Zhihua/0000-0002-1283-4649
FU NSFC [81660628]; Forth National Survey of Traditional Chinese Medicine
   Resources, Chinese or Tibet Medicinal Resources Investigation in Tibet
   Autonomous Region [20191217-540124, 20191223-540126, 20200501-542329]
FX We thank the support of the NSFC project (Grant NO. 81660628) and the
   Forth National Survey of Traditional Chinese Medicine Resources, Chinese
   or Tibet Medicinal Resources Investigation in Tibet Autonomous Region
   (Grant NO. 20191217-540124, 20191223-540126, and 20200501-542329) .
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NR 26
TC 11
Z9 12
U1 8
U2 87
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD DEC 1
PY 2021
VL 173
AR 114075
DI 10.1016/j.indcrop.2021.114075
EA SEP 2021
PG 8
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA WD4DX
UT WOS:000704894500006
DA 2026-05-27
ER

PT J
AU Sun, AQ
   Ju, XL
AF Sun, An-qi
   Ju, Xiu-Lian
TI Advances in Research on Anticancer Properties of Salidroside
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE salidroside; anticancer; mechanism; antiproliferative; Chinese medicine;
   review
ID RHODIOLA-ROSEA; COLORECTAL-CANCER; BLADDER-CANCER; SIGNALING PATHWAYS;
   CLINICAL-OUTCOMES; INHIBITION; EXPRESSION; EXTRACT; GROWTH; MICE
AB Salidroside is a phenolic secondary metabolite present in plants of the genusRhodiola, and studies investigating its extensive pharmacological activities and mechanisms have recently attracted increasing attention. This review summarizes the progress of recent research on the antiproliferative activities of salidroside and its effects on breast, ovarian, cervical, colorectal, lung, liver, gastric, bladder, renal, and skin cancer as well as gliomas and fibrosarcomas. Thus, it provides a reference for the further development and utilization of salidroside.
C1 [Sun, An-qi; Ju, Xiu-Lian] Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, Wuhan 430073, Peoples R China.
   [Sun, An-qi] Wuhan Inst Technol, Coll Post & Telecommun, Wuhan 430073, Peoples R China.
C3 Wuhan Institute of Technology; Wuhan Institute of Technology
RP Ju, XL (corresponding author), Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, Wuhan 430073, Peoples R China.
EM xiulianju2001@yahoo.com
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NR 79
TC 35
Z9 40
U1 2
U2 79
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD FEB
PY 2021
VL 27
IS 2
BP 153
EP 160
DI 10.1007/s11655-020-3190-8
EA MAR 2020
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA QA8TL
UT WOS:000562309300001
PM 32144560
DA 2026-05-27
ER

PT J
AU Feng, HS
   Zhang, D
   Yin, Y
   Kang, J
   Zheng, R
AF Feng, Haoshen
   Zhang, Dan
   Yin, Yan
   Kang, Jian
   Zheng, Rui
TI Salidroside ameliorated the pulmonary inflammation induced by cigarette
   smoke via mitigating M1 macrophage polarization by JNK/c-Jun
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE cigarette smoke; c-Jun; JNK; macrophage polarization; salidroside
ID ACTIVATION; PHOSPHORYLATION
AB Pulmonary inflammation induced by cigarette smoke (CS) promoted the development of chronic obstructive pulmonary disease (COPD), and macrophage polarization caused by CS modulated inflammatory response. Previous studies indicated that salidroside exerted therapeutic effects in COPD, but the anti-inflammatory mechanisms were not clear. This study aimed to explore the effects and mechanisms of salidroside on macrophage polarization induced by CS. Wistar rats received passively CS exposure and were treated intraperitoneally with salidroside at a low, medium or high dose. Lung tissues were stained with hematoxylin-eosin. Emphysema and inflammatory scores were evaluated by histomorphology. Lung function, cytokines, and cell differential counts in BALF were detected. The macrophage polarization was determined by immunohistochemistry in lung tissues. Alveolar macrophages (AMs) were isolated and treated with cigarette smoke extract (CSE), salidroside or inhibitors of relative pathways. The polarization status was determined by qPCR, and the protein level was detected by Western blotting. CS exposure induced emphysema and lung function deterioration. The inflammatory scores, cytokines level and neutrophils counts were elevated after CS exposure. Salidroside treatment partly ameliorated above abnormal. CS exposure activated M1 and M2 polarization of AMs in vivo and in vitro, and salidroside mitigated M1 polarization induced by CS. CSE activated the JNK/c-Jun in AMs and the M1 polarization of AMs was inhibited by the inhibitors of JNK and AP-1. Salidroside treatment deactivated the JNK/c-Jun, which indicated that salidroside mitigated the M1 polarization of AMs induced by CS via inhibiting JNK/c-Jun. Salidroside treatment ameliorated the pulmonary inflammation and M1 polarization of AMs induced by CS, and the process might be mediated by the deactivation of JNK/c-Jun.
C1 [Feng, Haoshen] China Med Univ, Dept Pulm & Crit Care Med, Shengjing Hosp, Shenyang, Peoples R China.
   [Zhang, Dan] Dalian Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 2, Dalian, Peoples R China.
   [Yin, Yan; Kang, Jian] China Med Univ, Inst Resp Dis, Dept Pulm & Crit Care Med, Hosp 1, Shenyang, Peoples R China.
   [Kang, Jian] China Med Univ, Inst Resp Dis, Dept Pulm & Crit Care Med, Hosp 1, 155,Nanjing North St, Shenyang 110001, Liaoning, Peoples R China.
   [Zheng, Rui] China Med Univ, Dept Pulm & Crit Care Med, Shengjing Hosp, 36,Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
C3 China Medical University; Dalian Medical University; China Medical
   University; China Medical University; China Medical University
RP Kang, J (corresponding author), China Med Univ, Inst Resp Dis, Dept Pulm & Crit Care Med, Hosp 1, 155,Nanjing North St, Shenyang 110001, Liaoning, Peoples R China.; Zheng, R (corresponding author), China Med Univ, Dept Pulm & Crit Care Med, Shengjing Hosp, 36,Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
EM kangjian58@163.com; zhengr@sj-hospital.org
OI Zhang, Dan/0009-0006-1696-1596
FU National Natural Science Foundation of China [81700041]; National Key
   R&D Program of China [2016YFC1304500]; 345 Talent Project of Shengjing
   Hospital
FX ACKNOWLEDGMENTS This study was supported by grants from the National
   Natural Science Foundation of China (Grant No. 81700041), the National
   Key R&D Program of China (grant No. 2016YFC1304500) and the 345 Talent
   Project of Shengjing Hospital.
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NR 35
TC 23
Z9 28
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD SEP
PY 2023
VL 37
IS 9
BP 4251
EP 4264
DI 10.1002/ptr.7905
EA MAY 2023
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA R2PR4
UT WOS:000997246700001
PM 37254460
OA Bronze
DA 2026-05-27
ER

PT J
AU Zheng, T
   Wang, QB
   Bian, F
   Zhao, Y
   Ma, WD
   Zhang, YH
   Lu, W
   Lei, P
   Zhang, LL
   Hao, XC
   Chen, L
AF Zheng, Tao
   Wang, Qibin
   Bian, Fang
   Zhao, Yan
   Ma, Weidong
   Zhang, Yonghong
   Lu, Wei
   Lei, Pan
   Zhang, Lulu
   Hao, Xincai
   Chen, Li
TI Salidroside alleviates diabetic neuropathic pain through regulation of
   the AMPK-NLRP3 inflammasome axis
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Diabetes mellitus; Neuropathic pain; Salidroside; AMP-activated protein
   kinase; NLRP3 inflammasome
ID INDUCED OXIDATIVE STRESS; FACTOR-KAPPA-B; INSULIN-RESISTANCE; HIGH
   GLUCOSE; MOUSE MODEL; ACTIVATION; NLRP3; CONTRIBUTES; INHIBITION;
   RHODIOLA
AB High glucose (HG)-induced nucleotide-binding and oligomerization (NACHT) domain, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome activation leads to diabetic neuropathic pain. We recently showed that salidroside could suppress NLRP3 inflammasome activation in hepatocytes exposed to HG. The aim of this study was to evaluate the analgesic effect of salidroside on diabetic rats and to explore its underlying mechanisms. Rat models with diabetic neuropathic pain were induced by high-fat diet feeding combined with low dose streptozotocin injections. Doses of salidroside at 50 and 100 mg.kg(-1).day(-1) were administered by gavage to diabetic rats for 6 weeks. Mechanical allodynia test, thermal hyperalgesia test and biochemical analysis were performed to evaluate therapeutic effects. Primary dorsal root ganglion (DRG) cells exposed to HG at 45 mM were used to further study the effects of salidroside on the AMP-activated protein kinase (AMPK)-NLRP3 inflammasome axis and insulin sensitivity in vitro. Salidroside administration improved hyperglycemia, ameliorated insulin resistance, and alleviated neuropathic pain in diabetic rats. Moreover, salidroside induced AMPK activation and suppressed NLRP3 inflammasome activation in the DRGs of diabetic rats. In addition, salidroside treatment relieved oxidative stress, improved insulin sensitivity and regulated the AMPK-NLRP3 inflammasome axis in HG-treated DRGs in vitro. Furthermore, AMPK inhibition in vivo or AMPK silencing in vitro abolished the beneficial effects of salidroside on diabetic neuropathic pain. Together, these results indicate that salidroside alleviates diabetic neuropathic pain through its regulation of the AMPK-NLRP3 inflammasome axis in DRGs.
C1 [Zheng, Tao; Zhao, Yan; Ma, Weidong; Zhang, Yonghong; Lei, Pan; Chen, Li] Hubei Univ Med, Inst Wudang Tradit Chinese Med, Taihe Hosp, Shiyan, Hubei, Peoples R China.
   [Zheng, Tao; Wang, Qibin; Lu, Wei; Chen, Li] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan, Hubei, Peoples R China.
   [Bian, Fang] Hubei Univ Arts & Sci, Xiangyang Cent Hosp, Dept Pharm, Affiliated Hosp, Xiangyang, Hubei, Peoples R China.
   [Lei, Pan; Hao, Xincai] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan, Hubei, Peoples R China.
   [Zhang, Lulu] Hubei Univ Med, Taihe Hosp, Dept Hematol, Shiyan, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Medicine; Hubei
   University of Arts & Science; Hubei University of Medicine; Hubei
   University of Medicine
RP Zheng, T; Chen, L (corresponding author), 32 Renming Rd, Shiyan 442000, Hubei, Peoples R China.
EM ztice@foxmail.com; chenli0201@sina.com
RI Zheng, Tao/JOZ-1467-2023
OI Zheng, Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81703582, 81900141]; Hubei
   Provincial Natural Science Foundation of China [2016CFB153, 2018CFB174,
   2020CFB713]; Health Commission of Hubei Province Scientific Research
   Project [WJ2019M057]; Innovative Research Program for Graduate of Hubei
   University of Medicine [YC2019029]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81703582 and 81900141), the Hubei Provincial
   Natural Science Foundation of China (2016CFB153, 2018CFB174 and
   2020CFB713), the Health Commission of Hubei Province Scientific Research
   Project (WJ2019M057) and the Innovative Research Program for Graduate of
   Hubei University of Medicine (YC2019029).
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NR 55
TC 50
Z9 61
U1 1
U2 32
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR 1
PY 2021
VL 416
AR 115468
DI 10.1016/j.taap.2021.115468
EA FEB 2021
PG 12
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA RF9RT
UT WOS:000635176000002
PM 33639149
DA 2026-05-27
ER

PT J
AU Cai, H
   Wang, J
   Mo, YQ
   Ye, L
   Zhu, GP
   Song, XX
   Zhu, MC
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   Yang, CY
   Jin, ML
AF Cai, Hui
   Wang, Jian
   Mo, Yuqing
   Ye, Ling
   Zhu, Guiping
   Song, Xixi
   Zhu, Mengchan
   Xue, Xiaomin
   Yang, Chengyu
   Jin, Meiling
TI Salidroside suppresses group 2 innate lymphoid cell-mediated allergic
   airway inflammation by targeting IL-33/ST2 axis
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Airway inflammation; Asthma; Group 2 innate lymphoid cell;
   IL-33; ST2
ID CORTICOSTEROID RESISTANCE; SYNTHETIC SALIDROSIDE; CYTOKINES;
   PROLIFERATION; OVALBUMIN; ASTHMA; ILC2
AB Salidroside, an active component extracted from Rhodiola rosea, has been reported to inhibit allergic asthma. However, its mechanism has not been fully elucidated. Group 2 innate lymphoid cells (ILC2s) accumulate in the lung and cooperate with other cells to drive type 2 inflammation stimulated by inhaled allergens. The study aims to explore the suppressive effect of salidroside on ILC2s and IL-33/IL-33R (ST2) axis in allergic airway inflammation. The ovalbumin (OVA)-sensitized/challenged mice were established. Airway eosinophil recruitment, increased total IgE in the serum and type 2 cytokines IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluids and lung tissues were identified in the OVA-induced mice model, all of which were inhibited by pretreatment with different doses of salidroside. Moreover, salidroside suppressed lung total ILC2 and ST2-expressing ILC2 accumulation, lung IL-33 and ST2 expressions in mice. In vitro, OVA could induce IL-33 expression in BEAS-2B cells, which was also effectively inhibited by salidroside. This study firstly reveals salidroside as a potential therapeutic drug for allergic asthma by inhibiting ILC2-mediated airway inflammation via targeting IL-33/ST2 axis.
C1 [Cai, Hui; Wang, Jian; Mo, Yuqing; Ye, Ling; Zhu, Guiping; Song, Xixi; Zhu, Mengchan; Xue, Xiaomin; Yang, Chengyu; Jin, Meiling] Fudan Univ, Zhongshan Hosp, Dept Resp Med, Shanghai, Peoples R China.
C3 Fudan University
RP Jin, ML (corresponding author), Zhongshan Hosp, Dept Resp Med, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
EM jin.meiling@zs-hospital.sh.cn
RI Jin, Meiling/L-4014-2016; SONG, XIXI/HOH-7336-2023
FU National Key R&D Program of China [2016YFC1304000, 2016YFC1304002]
FX This study was supported by grants from the National Key R&D Program of
   China (2016YFC1304000, 2016YFC1304002).
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NR 34
TC 17
Z9 24
U1 3
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD APR
PY 2020
VL 81
AR 106243
DI 10.1016/j.intimp.2020.106243
PG 8
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA LG1TN
UT WOS:000527892200071
PM 32070919
DA 2026-05-27
ER

PT J
AU Ouyang, Q
   Tian, SY
   Zhou, HY
   Mao, Y
   Li, X
   Yan, F
   Liu, AL
   Hu, X
   You, CQ
   He, J
AF Ouyang, Qi
   Tian, Shengye
   Zhou, Hengyu
   Mao, Ying
   Li, Xiang
   Yan, Feng
   Liu, Ailong
   Hu, Xiang
   You, Changqiao
   He, Jun
TI Salidroside inhibits melanin synthesis and melanoma growth via mTOR and
   PI3K/Akt pathways
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE network pharmacology; salidroside; melanoma; oxidative stress;
   PI3K/Akt/mTOR pathway
ID TRANSCRIPTION FACTOR; MELANOGENESIS; HYPERPIGMENTATION; PIGMENTATION;
   NETWORK; SKIN
AB Background Melanomas are caused by the malignant transformation of melanocytes. Numerous studies have demonstrated that the tyrosol components of salidroside inhibit tyrosinase activity. The PI3K/Akt/mTOR signaling pathway plays a crucial role in biological pigment synthesis. However, how salidroside achieves its anti-melanoma effect in melanoma by regulating PI3K/Akt/mTOR remains poorly understood. This study aimed to explore the effect of salidroside on PI3K/Akt/mTOR in melanoma, which plays a role in regulating melanogenesis.Methods Network pharmacology was predicted that salidroside may exert an anti-melanoma effect through modulating melanin synthesis functions and signaling pathways. Zebrafish whole-embryo in situ hybridization, RT-qPCR, melanin synthesis and tumorigenesis assays, and were performed to investigate the therapeutic efficacy of salidroside in melanin synthesis. The mechanism of salidroside in anti-melanoma activity was examined by RT-qPCR, Western blot, immunofluorescence, in vivo imaging, immunohistochemistry.Results We confirmed salidroside may exert an anti-melanoma effect through modulating melanin synthesis-related gene expression and PI3K/Akt pathway by Network pharmacology. Furthermore, salidroside slowed melanin synthesis in zebrafish embryos and H2O2-induced B16F10 cells by inhibited oxidative stress. Moreover, we determined the effect of salidroside on anti-melanin synthesis via PI3K/Akt/mTOR pathway in vitro, and western blot results showed that salidroside increased the expression of Nrf2 in the nucleus, as well as inhibited the phosphorylation of mTOR and PI3K/Akt pathway. Finally, intratumoral administration showed salidroside suppressed melanoma growth.Conclusion Salidroside inhibits melanin synthesis and melanoma development most likely by its antioxidant properties and downregulating the PI3K/Akt/mTOR pathway. Our results may provide a novel therapeutic strategy for the treatment of melanoma.
C1 [Ouyang, Qi; Tian, Shengye; Zhou, Hengyu; Li, Xiang; He, Jun] Hunan Normal Univ, Changsha Hosp Maternal & Child Hlth Care, Hunan Prov Key Lab Reg Hereditary Birth Defects Pr, Changsha, Peoples R China.
   [Ouyang, Qi; Tian, Shengye; Zhou, Hengyu; Mao, Ying; Yan, Feng; Liu, Ailong; Hu, Xiang; You, Changqiao] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha, Peoples R China.
   [Yan, Feng; Liu, Ailong; You, Changqiao] Hunan Landfar Biotechnol Co Ltd, Hunan Prov Engn Technol Res Ctr Stem Cell Exosome, Changsha, Peoples R China.
C3 Hunan Normal University; Hunan Normal University
RP He, J (corresponding author), Hunan Normal Univ, Changsha Hosp Maternal & Child Hlth Care, Hunan Prov Key Lab Reg Hereditary Birth Defects Pr, Changsha, Peoples R China.; Hu, X; You, CQ (corresponding author), Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha, Peoples R China.; You, CQ (corresponding author), Hunan Landfar Biotechnol Co Ltd, Hunan Prov Engn Technol Res Ctr Stem Cell Exosome, Changsha, Peoples R China.
EM huxiang@hunnu.edu.cn; youcq@landfar.cn; hejun280@hunnu.edu.cn
RI Hu, Xiang/OUH-7089-2025; 严, 峰/KHU-0912-2024
FU Open research fund of Hunan Provincial Key Laboratory of Regional
   Hereditary Birth Defects Prevention and Control [HPKL2023005]; Key
   Research and Development Program of Hunan Province [2024JK2139];
   Innovation and entrepreneurship fund for college students of Hunan
   Normal University [2023275]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   the open research fund of Hunan Provincial Key Laboratory of Regional
   Hereditary Birth Defects Prevention and Control (HPKL2023005), Key
   Research and Development Program of Hunan Province (2024JK2139), and
   Innovation and entrepreneurship fund for college students of Hunan
   Normal University (2023275).
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NR 49
TC 2
Z9 2
U1 10
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUL 10
PY 2025
VL 15
AR 1583580
DI 10.3389/fonc.2025.1583580
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5EX4M
UT WOS:001534052300001
PM 40708947
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, R
   Ma, YQ
   Zhang, J
   Meng, AG
   Liu, CY
AF Zhang, Rui
   Ma, Yuqin
   Zhang, Jing
   Meng, Aiguo
   Liu, Chunyan
TI Salidroside induces ferroptosis in breast cancer cells and enhances the
   anticancer effect of oxaliplatin
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Breast cancer; Salidroside; Ferroptosis; Oxaliplatin
AB Salidroside, derived from Rhodiola rosea as both food and medicine, holds promise in cancer therapy but its efficacy against breast cancer is unknown. This study explored the impact of Rhodiola rosea aqueous extracts (Rre) and salidroside, alone and combined with oxaliplatin, on MDA-MB-231 and MDA-MB-453 breast cancer cells. Based on network pharmacology and bioinformatics, potential mechanism of salidroside on breast cancer focused on the ferroptosis signaling pathway. CCK-8 assays indicated that salidroside inhibits cell proliferation, enhancing oxaliplatin's antitumor effects. qPCR and Western blot analyses revealed decreased SLC7A11 mRNA and protein, reduced GPX4 and GSH levels, and altered GSH, MDA, and Fe contents. Molecular docking and Molecular dynamics simulations results confirmed a strong and stable interaction between SLC7A11 and salidroside. These results suggest that salidroside may induce ferroptosis in breast cancer cells by modulating SLC7A11 and enhance oxaliplatin efficacy, presenting a novel strategy for treating oxaliplatin-resistant triplenegative and HER2-positive breast cancers.
C1 [Zhang, Rui; Ma, Yuqin; Zhang, Jing; Meng, Aiguo] North China Univ Sci & Technol, Affiliated Hosp, Lab Dept, Tangshan 063000, Hebei, Peoples R China.
   [Meng, Aiguo] North China Univ Sci & Technol, Tangshan Key Lab Mol Med, Tangshan 063000, Hebei, Peoples R China.
   [Zhang, Jing] Zhangjiakou First Hosp, Lab Dept, Zhangjiakou 075041, Hebei, Peoples R China.
   [Liu, Chunyan] North China Univ Sci & Technol, Pharm Coll, Tangshan 063210, Hebei, Peoples R China.
C3 North China University of Science & Technology; North China University
   of Science & Technology; North China University of Science & Technology
RP Meng, AG (corresponding author), North China Univ Sci & Technol, Affiliated Hosp, Lab Dept, Tangshan 063000, Hebei, Peoples R China.; Liu, CY (corresponding author), North China Univ Sci & Technol, Pharm Coll, Tangshan 063210, Hebei, Peoples R China.
EM magmaster@sina.com; chunyanliu@ncst.edu.cn
FU Natural Science Foun-dation of hebei Province [H2021209056]
FX <BOLD>Funding</BOLD> This research was funded by grants from the Natural
   Science Foun-dation of hebei Province (No. H2021209056) .
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NR 49
TC 1
Z9 1
U1 5
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2025
VL 130
AR 106932
DI 10.1016/j.jff.2025.106932
EA JUN 2025
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 3UE3X
UT WOS:001509095900001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, YL
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   Liu, J
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AF Jin, Ying-Lan
   Zhang, Xiao-Min
   Chen, Xi
   Liu, Juan
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   Wang, Jing-Hua
TI Salidroside induces apoptosis via ERK1/2 in human leukemia K562 cells
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Leukemia; salidroside; apoptosis; ERK1/2
ID PROTEIN-KINASE ACTIVATION; CYCLE ARREST; SIGNALING PATHWAY; HL-60 CELLS;
   DEATH; INVOLVEMENT; MECHANISM; GROWTH
AB Salidroside, a phenylpropanoid glycoside present in all species of Rhodiola genus, shows a broad spectrum of pharmacological properties. Here we investigated the effects of salidroside on the viability, cell cycle, apoptosis and its possible molecular mechanisms. Cell viability assay was used to evaluate the cytotoxic effects of salidroside on human leukemia K562 cells, and flow cytometry analyzed the change of cell cycle distribution, cell apoptosis, MMP level and ROS generation induced by salidroside. Western blotting further studied the expression changes of PCNA, CyclinD1, Bax, Bcl-2 and caspase-3, and the activation of ERK1/2 was also detected. We found that salidroside inhibited the growth of K562 cells in dose-and time-dependent manners, caused G2-M phase arrest and induced apoptosis via mitochondrial pathway. Salidroside could result in a decrease of PCNA, CyclinD1 and Bcl-2, and upregulated the levels of Bax and caspase-3 as well as inactivation of ERK1/2. In conclusion, these results suggest that salidroside inhibits cell viability and induces cell cycle arrest and apoptosis via inactivation of ERK1/2 signaling pathway in human leukemia K562 cells and may be a promising candidate for leukemia treatment.
C1 [Jin, Ying-Lan; Zhang, Xiao-Min; Chen, Xi; Liu, Juan; Chang, Yu-Ying; Gao, Xin-Yu; Xue, Yan-Ming; Dong, Xiu-Shuai; Liu, Yao; Tian, Yao-Yao; Chen, Li-Yan; Wang, Ying; Wang, Jing-Hua] Harbin Med Univ, Dept Hematol, Affiliated Hosp 2, 246 Xuefu Rd, Harbin 150086, Peoples R China.
C3 Harbin Medical University
RP Wang, JH (corresponding author), Harbin Med Univ, Dept Hematol, Affiliated Hosp 2, 246 Xuefu Rd, Harbin 150086, Peoples R China.
EM wjhharbin@126.com
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NR 30
TC 1
Z9 2
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 9
BP 17588
EP 17595
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EA5OT
UT WOS:000386671100058
DA 2026-05-27
ER

PT J
AU Ying, YK
   Luo, J
AF Ying, Yukang
   Luo, Jun
TI Salidroside promotes human periodontal ligament cell proliferation and
   osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; human periodontal ligament cells; proliferation;
   extracellular signal-regulated kinase 1/2; phosphoinositide-3 kinase/Akt
ID ACTIVATED PROTEIN-KINASES; IN-VITRO; CANCER CELLS; BONE LOSS; KAPPA-B;
   DIFFERENTIATION; APOPTOSIS; MAPK; ANGIOGENESIS; INHIBITION
AB Salidroside modulates cell proliferation and serves as an anti-inflammatory and anti-apoptotic agent with efficacy against various diseases. The objective of the present study was to investigate the efficacy of salidroside in enhancing the proliferation of human periodontal ligament cells (hPDLCs). hPDLCs were isolated and the effects of salidroside on cell viability, soluble osteocalcin levels and activation of proliferation-associated signaling pathways were determined using a CCK-8 assay, ELISA and Western blotting, respectively. The results indicated that salidroside induced proliferation of hPDLCs, increased secretion of soluble osteocalcin and enhanced activation of extracellular signal-regulated kinase (ERK) 1/2 and phosphoinositide-3 kinase (PI3K)/Akt signaling pathways. These factors were upregulated by salidroside in a dose-dependent manner. The results of the present study suggested that salidroside mediated hPDLC proliferation via the ERK1/2 and PI3K/Akt signaling pathways, as well as osteocalcin secretion. Salidroside may therefore be used as a novel therapeutic agent in the treatment of the tooth-supporting apparatus, progressive tooth destruction or periodontitis.
C1 [Ying, Yukang; Luo, Jun] Taizhou Cent Hosp, Dept Stomatol, 999 Donghai Ave, Taizhou 318000, Zhejiang, Peoples R China.
C3 Taizhou University
RP Luo, J (corresponding author), Taizhou Cent Hosp, Dept Stomatol, 999 Donghai Ave, Taizhou 318000, Zhejiang, Peoples R China.
EM junluo_1@126.com
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NR 40
TC 12
Z9 12
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUN
PY 2018
VL 15
IS 6
BP 5041
EP 5045
DI 10.3892/etm.2018.6006
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GJ3FB
UT WOS:000435174400063
PM 29805528
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, Y
   Li, LQ
   Lin, L
   Liu, JX
   Zhang, ZH
   Xu, DJ
   Xiang, FJ
AF Zhang, Ying
   Li, Liqun
   Lin, Li
   Liu, Jianxun
   Zhang, Zaohua
   Xu, Dongjin
   Xiang, Feijun
TI Pharmacokinetics, Tissue Distribution, and Excretion of Salidroside in
   Rats
SO PLANTA MEDICA
LA English
DT Article
DE salidroside; pharmacokinetics; excretion; distribution; HPLC-UV; LC-MS;
   MS; Rhodiola; Crassulaceae
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY;
   ADIPOSE-TISSUE; RHODIOLA-SACHALINENSIS; ENDOCRINE FUNCTION; OXIDATIVE
   STRESS; PLASMA; CELLS; EXTRACTION; TYROSOL
AB The present study investigated the pharmacokinetics, excretion, and tissue distribution of salidroside, a main active constituent in the roots of Rhodiola species. The plasma concentration declined rapidly following the intravenous dosing at 7.5, 15, and 30mg/kg with a short half-life time of about 1h. The mean values of area under the concentration-time curve (300.48 +/- 36.73, 514.51 +/- 134.99, and 1036.64 +/- 101.67mgmin/L), total body clearance (0.025 +/- 0.003, 0.031 +/- 0.008, and 0.029 +/- 0.003L/min/kg), and distribution value (2.02 +/- 0.80, 2.47 +/- 1.09 and 2.58 +/- 0.68L/kg) suggested linear pharmacokinetics between the three doses. After intravenous injection of salidroside at 15mg/kg, the total cumulative recovery of salidroside in urine was 53.67 +/- 12.03% over 48h, but only 0.09 +/- 0.03% and 0.18 +/- 0.18% of the dosage was excreted in bile and feces. Concentrations of salidroside in 12 tissues as well as plasma were evaluated at 15, 40, and 120min after dosing. At all time points, no higher concentration of salidroside was detected in tissues than that in plasma, with the lowest concentration of salidroside being observed in the brain, liver, fat, and skeletal muscle were tissues with a higher concentration of salidroside. A better distribution was also observed in the ovary and testis than that in the kidney and spleen. This finding demonstrated that salidroside is eliminated from plasma rapidly mainly by kidney clearance and conspicuously penetrated well into the skeletal muscle, fat, ovary and testis. A total recovered salidroside of about 54% from excretion routes suggested that the metabolism was likely to take an important role in its elimination.
C1 [Zhang, Ying; Li, Liqun; Lin, Li; Liu, Jianxun] China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China.
   [Zhang, Zaohua] China Acad Chinese Med Sci, Inst Informat Tradit Chinese Med, Beijing 100091, Peoples R China.
   [Xu, Dongjin; Xiang, Feijun] Kangmei Pharmaceut Co Ltd, Guangzhou, Guangdong, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS;
   Institute of Information on Traditional Chinese Medicine, CACMS; China
   Academy of Chinese Medical Sciences
RP Liu, JX (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, 1 Xiyuan Caochang, Beijing 100091, Peoples R China.
EM jianxun_liu@163.com
OI Liu, Jianxun/0000-0002-0613-7388
CR [Anonymous], CLIN CORNERSTONE
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NR 25
TC 42
Z9 46
U1 2
U2 69
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD OCT
PY 2013
VL 79
IS 15
BP 1429
EP 1433
DI 10.1055/s-0033-1350807
PG 5
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 304CR
UT WOS:000330724200007
PM 24043591
DA 2026-05-27
ER

PT J
AU Zhao, HB
   Ma, H
   Ha, XQ
   Zheng, P
   Li, XY
   Zhang, M
   Dong, JZ
   Yang, YS
AF Zhao, Hong-Bin
   Ma, Hui
   Ha, Xiao-Qin
   Zheng, Ping
   Li, Xiao-Yun
   Zhang, Ming
   Dong, Ju-Zi
   Yang, Yin-Shu
TI Salidroside induces rat mesenchymal stem cells to differentiate into
   dopaminergic neurons
SO CELL BIOLOGY INTERNATIONAL
LA English
DT Article
DE salidroside; mesenchymal stem cells; dopaminergic neuron
ID MARROW STROMAL CELLS; NEURAL DIFFERENTIATION; GENE-EXPRESSION; BONE;
   PROGENITORS; PRECURSORS
AB Parkinson's disease (PD) is a neurodegenerative disorder characterised by the loss of substantia nigra dopaminergic neurons that leads to a reduction in striatal dopamine (DA) levels. Replacing lost cells by transplanting dopaminergic neurons has potential value to repair the damaged brain. Salidroside (SD), a phenylpropanoid glycoside isolated from plant Rhodiola rosea, is neuroprotective. We examined whether salidroside can induce mesenchymal stem cells (MSCs) to differentiate into neuron-like cells, and convert MSCs into dopamine neurons that can be applied in clinical use. Salidroside induced rMSCs to adopt a neuronal morphology, upregulated the expression of neuronal marker molecules, such as gamma neuronal enolase 2 (Eno2/NSE), microtubule-associated protein 2 (Map2), and beta 3 class III tubulin (Tubb3/beta-tubulin III). It also increased expression of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and nerve growth factor (NGF) mRNAs, and promoted the secretion of these growth factors. The expression of dopamine neurons markers, such as dopamine-beta-hydroxy (DBH), dopa decarboxylase (DDC) and tyrosine hydroxylase (TH), was significantly upregulated after treatment with salidroside for 1-12 days. DA steadily increased after treatment with salidroside for 1-6 days. Thus salidroside can induce rMSCs to differentiate into dopaminergic neurons.
C1 [Zhao, Hong-Bin; Ma, Hui; Li, Xiao-Yun; Zhang, Ming; Yang, Yin-Shu] Gen Hosp Lanzhou Mil Command PLA, Inst Orthoped, Lanzhou 730050, Gansu, Peoples R China.
   [Ha, Xiao-Qin; Zheng, Ping; Dong, Ju-Zi] Gen Hosp Lanzhou Mil Command PLA, Dept Clin Lab, Lanzhou 730050, Gansu, Peoples R China.
RP Zhao, HB (corresponding author), Gen Hosp Lanzhou Mil Command PLA, Inst Orthoped, Lanzhou 730050, Gansu, Peoples R China.
EM zhao6703@aliyun.com
FU National Natural Science Foundation of China [81073156]; Natural Science
   Foundation of Gansu Province, China [0710RJZA067]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81073156) and the Natural Science Foundation of Gansu
   Province, China (No. 0710RJZA067).
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NR 20
TC 29
Z9 35
U1 1
U2 26
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-6995
EI 1095-8355
J9 CELL BIOL INT
JI Cell Biol. Int.
PD APR
PY 2014
VL 38
IS 4
BP 462
EP 471
DI 10.1002/cbin.10217
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AC2QF
UT WOS:000332348300007
PM 24323403
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, H
   Dong, WW
   Li, SY
   Zhang, YQ
   Lv, Z
   Yang, L
   Jiang, L
   Wu, T
   Wang, Y
AF Zhang, Hui
   Dong, Wenwen
   Li, Siyuan
   Zhang, Yunqian
   Lv, Zhou
   Yang, Lu
   Jiang, Lai
   Wu, Tao
   Wang, Yan
TI Salidroside protects against ventilation-induced lung injury by
   inhibiting the expression of matrix metalloproteinase-9
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Acute lung injury; endothelial dysfunction; NF-kappa B signalling
   pathway
ID NF-KAPPA-B; PULMONARY-FIBROSIS; RHODIOLA-ROSEA; ACTIVATION; PREVENTS;
   INFLAMMATION; DEGRADATION; RESVERATROL; MECHANISMS; JUNCTIONS
AB Context: Salidroside, a compound extracted from Rhodiola rosea L. (Crassulaceae), possesses many beneficial pathological effects.
   Objective: To explore the effect of salidroside on ventilator-induced lung endothelial dysfunction in vivo and in vitro.
   Materials and methods: In vivo, male ICR mice were divided into sham, ventilation, salidroside, and ventilation plus salidroside groups. The mice were ventilated for 4 h, salidroside (50 mg/kg) was administrated intraperitoneally before ventilation, dexamethasone (Dex) (5 mg/kg) was used as a positive control. In vitro, mouse lung vascular endothelial cells (MLVECs) were treated with salidroside, MMP-9 siRNA, and BAY11-7082 (10 mu M), and then exposed to cyclic stretch for 4 h. Afterward, lung tissues and MLVECs were collected for further analysis.
   Results: Salidroside pre-treatment significantly reversed the expression of vascular endothelial cadherin (VE-cadherin) and zonula occluden-1 (ZO-1) proteins in cyclic stretch-treated MLVECs (0.46 +/- 0.09 vs. 0.80 +/- 0.14, 0.49 +/- 0.05 vs. 0.88 +/- 0.08) and ventilated lung tissues (0.56 +/- 0.06 vs. 0.83 +/- 0.46, 0.49 +/- 0.08 vs. 0.80 +/- 0.12). The results further indicated that salidroside inhibited the expression of matrix metalloproteinase-9 (MMP-9), whereas knockdown of its expression restored the expression levels of VE-cadherin (0.37 +/- 0.08 vs. 0.85 +/- 0.74) and ZO-1 (0.48 +/- 0.08 vs. 0.81 +/- 0.11) in stretched MLVECs. Meanwhile, salidroside inhibited the NF-kappa B signalling pathway and alleviated lung injury.
   Conclusions: Salidroside protected against stretch-induced endothelial barrier function, improving lung injury after ventilation. Thus, salidroside may be a promising therapeutic agent for patients with MV-induced lung injury.
C1 [Zhang, Hui; Dong, Wenwen; Li, Siyuan; Zhang, Yunqian; Lv, Zhou; Jiang, Lai; Wang, Yan] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Anesthesiol, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
   [Zhang, Hui; Dong, Wenwen; Li, Siyuan; Zhang, Yunqian; Lv, Zhou; Jiang, Lai; Wang, Yan] Shanghai Jiao Tong Univ, Xinhua Hosp, Surg Intens Care Unit, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
   [Yang, Lu] Shanghai Univ Sport, Sch Kinesiol, Key Lab Exercise & Hlth Sci, Minist Educ, Shanghai, Peoples R China.
   [Wu, Tao] Shanghai Jiao Tong Univ, Sch Med, 227 South Chongqing Rd, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   University of Sport; Shanghai Jiao Tong University
RP Wang, Y (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Anesthesiol, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.; Wang, Y (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Surg Intens Care Unit, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.; Wu, T (corresponding author), Shanghai Jiao Tong Univ, Sch Med, 227 South Chongqing Rd, Shanghai 200025, Peoples R China.
EM wutao0324@shsmu.edu.cn; wangyan@xinhuamed.com.cn
RI Li, Siyuan/JQW-0126-2023
FU Shanghai Municipal Commission of Health and Family Planning [2017BR062];
   Shanghai Science and Technology Commission [19XD1402600, 18YF1415500,
   19YF1432600]; National Natural Science Foundation of China [82002070]
FX This work was supported by grants from Shanghai Municipal Commission of
   Health and Family Planning to Dr. Jiang (No. 2017BR062), Shanghai
   Science and Technology Commission to Dr. Jiang (No. 19XD1402600), Dr.
   Wang (18YF1415500), Dr. Lv (19YF1432600), and National Natural Science
   Foundation of China to Dr. Wang (No. 82002070).
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NR 49
TC 10
Z9 12
U1 1
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD JAN 1
PY 2021
VL 59
IS 1
BP 760
EP 768
DI 10.1080/13880209.2021.1967409
PG 9
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA UQ1WQ
UT WOS:000695861900001
PM 34517742
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, Y
   Chen, Z
   Luo, J
   Zhang, J
   Sang, AM
   Cheng, ZS
   Li, XY
AF Wang, Yun
   Chen, Zhe
   Luo, Jing
   Zhang, Jing
   Sang, A-ming
   Cheng, Zhen-shun
   Li, Xin-yi
TI Salidroside postconditioning attenuates ferroptosis-mediated lung
   ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling
   axis
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Lung ischemia-reperfusion; Salidroside; Ferroptosis; Nrf2
ID TARGET
AB Background: Ferroptosis, an iron-dependent programmed necrosis, is linked to lung ischemia-reperfusion injury. Salidroside is a glycoside derived from the Rhodiola rosea plant that exhibits anti-inflammatory and antioxidant properties. However, it is uncertain whether salidroside alleviates lung ischemia-reperfusion injury. This investigation explored the function of salidroside in ferroptosis in lung ischemia-reperfusion injury. Methods: A lung ischemia-reperfusion model was established in wild-type and Nrf2(-/- )mice, and pulmonary epithelial cells were exposed to hypoxia/regeneration in vitro. We evaluated ferroptosis-related factors by western blotting, transmission electron microscopy, and fluorescence microscopy. To investigate the regulation of Nrf2 by salidroside, coimmunoprecipitation and luciferase reporter assays were used. Transwell assays were used to detect macrophage migration. Results: The data indicated that salidroside postconditioning significantly reduced ferroptosis and alleviated lung ischemia-reperfusion injury in wild-type mice, as evidenced by improved histology and inflammation, reduced lipid peroxides and iron overload, and the induction of Nrf2, SLC7A11, and GPX4 expression. Salidroside activated Nrf2 signaling, resulting in Keap1-Nrf2 dissociation, nuclear translocation, and increased antioxidantresponse element reporter activity. Sal consistently inhibited hypoxia/regeneration-induced pulmonary epithelial cell ferroptosis by activating the Nrf2 signaling pathway. Furthermore, ferroptotic cells recruited macrophages via CCL2, whereas salidroside lowered CCL2 expression and inhibited ferroptosis-induced macrophage chemotaxis in lung ischemia-reperfusion injury. Additionally, the antiferroptotic effects of salidroside against lung ischemia-reperfusion injury were eliminated in Nrf2(-/-) mice. Conclusions: This study clearly shows that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.
C1 [Wang, Yun; Luo, Jing; Zhang, Jing; Sang, A-ming; Li, Xin-yi] Zhongnan Hosp Wuhan Univ, Dept Anesthesiol, Wuhan 430071, Hubei, Peoples R China.
   [Chen, Zhe] Zhongnan Hosp Wuhan Univ, Dept Otolaryngol Head & Neck Surg, Wuhan 430071, Hubei, Peoples R China.
   [Cheng, Zhen-shun] Zhongnan Hosp Wuhan Univ, Dept Resp & Crit Care Med, Wuhan 430071, Hubei, Peoples R China.
   [Cheng, Zhen-shun] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan 430071, Hubei, Peoples R China.
   [Cheng, Zhen-shun] Hubei Engn Ctr Infect Dis Prevent Control & Treatm, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Chinese Academy of
   Medical Sciences - Peking Union Medical College
RP Li, XY (corresponding author), Zhongnan Hosp Wuhan Univ, Dept Anesthesiol, Wuhan 430071, Hubei, Peoples R China.; Cheng, ZS (corresponding author), Zhongnan Hosp Wuhan Univ, Dept Resp & Crit Care Med, Wuhan 430071, Hubei, Peoples R China.; Cheng, ZS (corresponding author), Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan 430071, Hubei, Peoples R China.; Cheng, ZS (corresponding author), Hubei Engn Ctr Infect Dis Prevent Control & Treatm, Wuhan 430071, Hubei, Peoples R China.
EM andy_987@126.com; zn001376@whu.edu.cn; rojane1991@126.com;
   annejinghoho@163.com; sangaming@163.com; chzs1990@163.com;
   lxy08272021@126.com
OI Wang, Yun/0000-0002-3644-3466
FU Hubei Province Natural Science Foundation [2020CFB214]; Climbing Project
   for Medical Talent of Zhongnan Hospital, Wuhan University [PDJH202205];
   National Natural Science Foundation of China [82002033]
FX This work was supported by the Hubei Province Natural Science Foundation
   (Y.W., 2020CFB214) , the Climbing Project for Medical Talent of Zhongnan
   Hospital, Wuhan University (Z.-S.C., No, PDJH202205) and the National
   Natural Science Foundation of China (X.-Y.L., No. 82002033) .
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NR 36
TC 36
Z9 42
U1 7
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD FEB
PY 2023
VL 115
AR 109731
DI 10.1016/j.intimp.2023.109731
EA JAN 2023
PG 12
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 8O8QV
UT WOS:000926097600001
PM 36907990
DA 2026-05-27
ER

PT J
AU Cao, XB
   Jiang, ZH
   Dong, L
   Zheng, Y
   Li, Y
AF Cao, Xue-bin
   Jiang, Zhi-hao
   Dong, Lei
   Zheng, Yu
   Li, Yang
TI Effects of Modulation of Ion Channel Currents by Salidroside in H9C2
   Myocardial Cells in Hypoxia and Reoxygenation
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
AB Salidroside, a phenyl-propanoid glycoside isolated from the medicinal plant Rhodiola rosea, has potent cardioprotective effects, especially against myocardial hypoxia and reoxygenation injury. However, the molecular mechanism underlying its action is still unclear. The aim of this study was to determine the effect of salidroside on sodium channel current (I-Na) and transient outward potassium channel current (I-to) in H9C2 cardiomyocytes. H9C2 cells were subcultured under anoxic conditions to mimic myocardial hypoxia and subsequently treated with salidroside. Whole cell patch clamp was performed to determine the effect of hypoxia/reoxygenation and salidroside on myocardial electrophysiological properties. In the differentiated H9C2 cells, hypoxia/reoxygenation reduced I-Na and I-to amplitude, while salidroside significantly restored both and altered the I-Na and I-to activation/inactivation kinetics in a dose-dependent manner. Our findings demonstrate that salidroside protects myocardial cells against hypoxia-reoxygenation by restoring the function of sodium and potassium channels.
C1 [Cao, Xue-bin] 252 Hosp PLA, Dept Cardiol, Baoding 071000, Hebei, Peoples R China.
   [Cao, Xue-bin; Li, Yang] Gen Hosp Peoples Liberat Army, Dept Cardiol, Beijing 100853, Peoples R China.
   [Jiang, Zhi-hao] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China.
   [Dong, Lei] Tianjin Univ, State Key Lab Precis Measurement Technol & Instru, Tianjin 300072, Peoples R China.
   [Zheng, Yu] Tianjin Polytech Univ, Tianjin Key Lab Optoelect Detect Technol & Syst, Tianjin 300387, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University;
   Tiangong University
RP Li, Y (corresponding author), Gen Hosp Peoples Liberat Army, Dept Cardiol, Beijing 100853, Peoples R China.; Zheng, Y (corresponding author), Tianjin Polytech Univ, Tianjin Key Lab Optoelect Detect Technol & Syst, Tianjin 300387, Peoples R China.
EM zhengyu@tjpu.edu.cn; liyangbsh@163.com
RI ; Jiang, Zhehan/K-7115-2019
OI Li, Yang/0000-0001-5706-1830; 
FU National Natural Science Foundation of China [61871288]
FX This work was supported by grants from the National Natural Science
   Foundation of China (61871288).
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NR 31
TC 9
Z9 11
U1 1
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 8212868
DI 10.1155/2019/8212868
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HW0CA
UT WOS:000466347300001
PM 30805019
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Alotaibi, NAS
   Slater, NKH
   Rahmoune, H
AF Alotaibi, Noha A. S.
   Slater, Nigel K. H.
   Rahmoune, Hassan
TI Salidroside as a Novel Protective Agent to Improve Red Blood Cell
   Cryopreservation
SO PLOS ONE
LA English
DT Article
ID HUMAN ERYTHROCYTES; OXIDATIVE STRESS; TREHALOSE; FROZEN; HEMOGLOBIN;
   SURVIVAL; ACP-215; STORAGE; RBCS
AB Glycerol and trehalose have been widely examined as protective agents in the cryopreservation of red blood cells (RBCs). However, the effectiveness of these reagents alone on cell viability is moderate. Here, the addition of salidroside attenuated oxidative damage of sheep RBCs prior to and post cryostorage. The supplementation of salidroside to the cryopreservation media containing 10% glycerol improved RBC survival by approximately 61.1+/-4.8% vs 37.9+/-4.6%. A smaller effect was seen in RBCs cryopreserved in 300 mM trehalose where the addition of salidroside improved survival by 7.6+/-0.3%. Furthermore, the addition of salidroside to cold storage solution demonstrated a significant reduction of haemolysis after 4 days for RBCs loaded with either glycerol or trehalose, compared to cells incubated without salidroside. RBCs survival was 2-fold greater following freezing in trehalose, compared with glycerol. After 10 days, salidroside enabled a lower haemolysis of 16.7+/-1.3% compared to 29.0+/-8.4% for cells incubated without salidroside. However, salidroside had no effect on RBCs which had been frozen in glycerol as the resulting haemolysis rate by day 10 was approximately 60%. Salidroside increased glutathione reductase activity and decreased lactate dehydrogenase activity. Furthermore, it led to reduced carbonylation of proteins in both glycerol and trehalose loaded cells. Finally, no effect on lipid peroxidation was found in the glycerol loaded RBCs although this was reduced in RBCs loaded with trehalose and salidroside. The present findings confirm the potential use of salidroside as a novel protective agent in cryopreservation and refrigerated storage of sheep RBCs.
C1 [Alotaibi, Noha A. S.; Slater, Nigel K. H.; Rahmoune, Hassan] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 3RA, England.
   [Alotaibi, Noha A. S.] King Abdulaziz City Sci & Technol Kingdom Saudi A, POB 6086, Riyadh 11442, Saudi Arabia.
C3 University of Cambridge
RP Rahmoune, H (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 3RA, England.
EM hr228@cam.ac.uk
FU King AbdulAziz City for Science and Technology (KACST)
FX King AbdulAziz City for Science and Technology (KACST) funded NASA. The
   funder provided support in the form of salaries for authors [NASA], but
   did not have any additional role in the study design, data collection
   and analysis, decision to publish, or preparation of the manuscript. The
   specific roles of these authors are articulated in the 'author
   contributions'.
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NR 31
TC 16
Z9 21
U1 1
U2 33
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 15
PY 2016
VL 11
IS 9
AR e0162748
DI 10.1371/journal.pone.0162748
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DW5SJ
UT WOS:000383706900073
PM 27631782
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, JF
   Zhao, F
   Ye, MY
   Ma, K
   Huang, WJ
   Qian, L
   Huang, XJ
   Fu, HY
   Lv, BD
AF Zhao, Jianfeng
   Zhao, Fan
   Ye, Miaoyong
   Ma, Ke
   Huang, Wenjie
   Qian, Le
   Huang, Xiaojun
   Fu, Huiyin
   Lv, Bodong
TI Salidroside Attenuates Hypoxia-Induced Expression of Connexin 43 in
   Corpus Cavernosum Smooth Muscle Cells
SO UROLOGIA INTERNATIONALIS
LA English
DT Article
DE Connexin 43; Hypoxia; Corpus cavernosum; Salidroside
ID ERECTILE DYSFUNCTION; MEN; PERMEABILITY
AB Introduction:Connexin 43 (Cx43) is the major component of gap junction in corpus cavernosum smooth muscle, which allows rapid intercellular communication. Cx43 coordinates corpus cavernosum smooth muscle cells and ensures erectile function. The role of hypoxia in Cx43 dysfunction resulting in erectile dysfunction has not been well studied, and salidroside has shown cell protective effects under hypoxia.Objective:We aimed to investigate the protective role of salidroside and the underlying mechanisms in hypoxia-induced dysfunction of Cx43.Methods:Corpus cavernosum smooth muscle cells prepared from young male Sprague-Dawley rats were pretreated with or without salidroside and exposed to hypoxic condition for 48 h. The cell viability, expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and Cx43, and Ca2+ signals were investigated.Results:Pretreatment with salidroside attenuated loss of hypoxia-induced cell viability markedly and could downregulate the HIF-1 alpha protein expression under hypoxia. Moreover, the expression of Cx43 was significantly increased by hypoxia but was decreased with salidroside pretreatment. The salidroside pretreated group exhibited enhanced release of intracellular Ca2+ in corpus cavernosum smooth muscle cells compared with the hypoxia group after stimulation.Conclusion:Salidroside has a protective effect against hypoxia-induced damage to corpus cavernosum smooth muscle cells.
C1 [Zhao, Jianfeng; Ye, Miaoyong; Ma, Ke; Huang, Wenjie; Qian, Le; Huang, Xiaojun; Fu, Huiyin; Lv, Bodong] Zhejiang Chinese Med Univ, Urol Dept, Affiliated Hosp 2, 318 Chaowang Rd, Hangzhou 310005, Peoples R China.
   [Zhao, Jianfeng; Huang, Wenjie; Huang, Xiaojun; Fu, Huiyin; Lv, Bodong] Zhejiang Prov Key Lab Tradit Chinese Med, Androl Lab Integrat Chinese & Western Med, Hangzhou, Peoples R China.
   [Zhao, Fan] Nantong Univ, Dept Urol & Androl, Affiliated Hosp, Nantong, Peoples R China.
C3 Zhejiang Chinese Medical University; Nantong University
RP Lv, BD (corresponding author), Zhejiang Chinese Med Univ, Urol Dept, Affiliated Hosp 2, 318 Chaowang Rd, Hangzhou 310005, Peoples R China.
EM bodonglv0571@163.com
FU National Natural Science Foundation of China [81603620, 81874400];
   Natural Science Foundation of Zhejiang Province [LQ19H040001]
FX This work was funded by the National Natural Science Foundation of China
   (Nos. 81603620 and 81874400) and the Natural Science Foundation of
   Zhejiang Province (No. LQ19H040001).
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NR 32
TC 4
Z9 7
U1 0
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0042-1138
EI 1423-0399
J9 UROL INT
JI Urol.Int.
PD AUG
PY 2020
VL 104
IS 7-8
BP 594
EP 603
DI 10.1159/000507099
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA MV5QM
UT WOS:000556412300013
PM 32615556
DA 2026-05-27
ER

PT J
AU Sun, Y
   Xun, LR
   Jin, G
   Shi, L
AF Sun, Yan
   Xun, Liru
   Jin, Gang
   Shi, Lei
TI Salidroside protects renal tubular epithelial cells from
   hypoxia/reoxygenation injury in vitro
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Acute kidney injury (AKI); Ischemia/reperfusion (I/R);
   Hypoxia/reoxygenation (H/R); Salidroside; Oxidative stress; Inflammation
ID ISCHEMIA-REPERFUSION INJURY; ISCHEMIA/REPERFUSION I/R INJURY; OXIDATIVE
   STRESS; ACTIVATION; APOPTOSIS; INDUCTION; LIVER; RATS
AB Oxidative stress, inflammation and cell apoptosis are important mechanisms of renal ischemia/reperfusion (I/R) injury. Salidroside, a natural phenylpropanoid glycoside, possesses anti-inflammatory, anti-oxidative, and anti-apoptotic effects. However, the effect of salidroside on renal I/R injury has not been fully elucidated. The present study aimed to investigate the effect of salidroside on renal I/R injury in vitro. Our results showed that salidroside improved the viability of human renal tubular epithelial cells (HK-2) in response to hypoxia/reoxygenation (H/R). Salidroside caused apparent decrease in the levels of reactive oxygen species (ROS) and malondiaidehyde (MDA), and significant increase in superoxide dismutase (SOD) activity in HK-2 cells. Pretreatment with salidroside markedly inhibited the production levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and IL-6 in a dose-dependent manner. Salidroside treatment exhibited significant increase in Bcl-2 expressions, and decrease in Bax expressions and caspase-3 activity when compared with the H/R group. Salidroside decreased the levels of toll-like receptor 4 (TLR4) and p-p65 in HK-2 cells. Overexpression of TLR4 significantly attenuated the effects of salidroside on cell viability, oxidative stress, cytokine production and cell apoptosis in HK-2 cells. These findings indicated that salidroside protected HK-2 cells from H/R stimulation, which was mediated by the TLR4/NF-kappa B pathway. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
C1 [Sun, Yan; Xun, Liru; Jin, Gang] Shaanxi Prov Peoples Hosp, Dept Nephrol, Xian 710068, Peoples R China.
   [Shi, Lei] Xi An Jiao Tong Univ, Dept Infect Dis, Affiliated Hosp 1, Xian 710061, Peoples R China.
C3 Xi'an Medical University; Xi'an Jiaotong University
RP Shi, L (corresponding author), Xi An Jiao Tong Univ, Dept Infect Dis, Affiliated Hosp 1, Xian 710061, Peoples R China.
EM shilei_xa@163.com
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NR 33
TC 39
Z9 46
U1 1
U2 19
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JUN
PY 2018
VL 137
IS 2
BP 170
EP 176
DI 10.1016/j.jphs.2018.05.011
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GO9UA
UT WOS:000440452000010
PM 29960844
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fei, SF
   Tong, DB
   Jia, F
AF Fei, Si -Fan
   Tong, De -Bing
   Jia, Fang
TI Antiatherosclerotic Effect and Molecular Mechanism of Salidroside
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE salidroside; atherosclerosis; endothelial dysfunction; cell targets;
   lipid metabolism; gut microbiota
ID SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-MESENCHYMAL TRANSITION; BARRIER
   DYSFUNCTION; OXIDATIVE STRESS; DOWN-REGULATION; GUT MICROBIOTA;
   ACTIVATION; ATHEROSCLEROSIS; PROLIFERATION; MACROPHAGES
AB Atherosclerotic cardiovascular disease is currently the leading cause of death worldwide. Its pathophysiological basis includes endothelial dysfunction, macrophage activation, vascular smooth muscle cell (VSMC) proliferation, lipid metabolism, platelet aggregation, and changes in the gut microbiota. Salidroside has beneficial effects on atherosclerosis through multiple pathways. In this review, we present studies on the regulatory effect of salidroside on atherosclerosis. Furthermore, we report the protective effects of salidroside against atherosclerosis by ameliorating endothelial dysfunction, suppressing macrophage activation and polarization, inhibiting VSMC proliferation, adjusting lipid metabolism, attenuating platelet aggregation, and modulating the gut microbiota. This review provides further understanding of the molecular mechanism of salidroside and new ideas for atherosclerosis management.
C1 [Fei, Si -Fan; Tong, De -Bing; Jia, Fang] Soochow Univ, Peoples Hosp Changzhou 1, Dept Cardiovasc Med, Affiliated Hosp 3, Changzhou 213000, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Jia, F (corresponding author), Soochow Univ, Peoples Hosp Changzhou 1, Dept Cardiovasc Med, Affiliated Hosp 3, Changzhou 213000, Jiangsu, Peoples R China.
EM jiafangsjs@126.com
FU Major Technology Projects of Changzhou Health Commission [ZD202212]
FX Funding This work was Funding from Major Technology Projects of
   Changzhou Health Commission (ZD202212) .
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NR 95
TC 5
Z9 5
U1 2
U2 30
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PD APR
PY 2023
VL 24
IS 4
DI 10.31083/j.rcm2404097
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA F6DH0
UT WOS:000983224300005
PM 39076283
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, ZY
   Yang, ZT
   Wang, DF
AF Wu, Zhenyu
   Yang, Zhitong
   Wang, Dengfeng
TI Antiosteoporosis Effect of Salidroside against Glucocorticoid-Induced
   Osteoporosis in Rats Via Reduction of Inflammation Reaction
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
ID DEXAMETHASONE-INDUCED OSTEOPOROSIS; CALCIUM
AB Osteoporosis is a bone disease that develops when bone mass and function are altered. Salidroside shown a bone-protective action against the disease of arthritis. We investigate the bone protective effect of salidroside against glucocorticoid (dexamethasone) induced osteoporosis in rats. In silico study was performed on the estrogen alpha receptor, estrogen beta receptor and vitamin D receptor. Sprague-Dawley (SD) was divided into different groups and treated with dexamethasone (7 mg/kg) for induction the osteoporosis. The different doses of salidroside (5, 10, and 15 mg/kg) and alendronate were given to the rats for 5 weeks. The body weight, biochemical, bone microstructure, bone parameters, antioxidant and inflammatory cytokines. In silico study showed the get better comprehension salidroside against the estrogen alpha, beta and vitamin D potency at molecular level. OS group rats exhibited the declined body weight and salidroside remarkably (p < 0.001) improved the body weight. Salidroside remarkably (p < 0.001) altered the bone microstructure, bone parameters, biochemical parameters. Salidroside remarkably (p < 0.001) repressed the level of parathyroid hormones and augmented the level of 1,25-(OH)2-vitamin D 3. Salidroside remarkably (p < 0.001) boosted the level of nutrients and altered the level of antioxidant parameters and cytokines. Salidroside exhibited the antiosteoporosis effect against DEX induced osteoporosis in the rats.
C1 [Wu, Zhenyu] Beihua Univ, Dept Orthoped 1, Affiliated Hosp, Jilin 132011, Jilin, Peoples R China.
   [Yang, Zhitong] Dalian Univ Technol, Dept Orthopaed, Cent Hosp, Dalian 116000, Liaoning, Peoples R China.
   [Wang, Dengfeng] Xi An Jiao Tong Univ, Honghui Hosp, Dept Shoulder & Elbow Sports Med, Xian 710054, Shaanxi, Peoples R China.
C3 Beihua University; Dalian University of Technology; Xi'an Jiaotong
   University
RP Wang, DF (corresponding author), Xi An Jiao Tong Univ, Honghui Hosp, Dept Shoulder & Elbow Sports Med, Xian 710054, Shaanxi, Peoples R China.
EM wdf18502909278@sina.com
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NR 35
TC 2
Z9 2
U1 2
U2 5
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2023
VL 42
IS 4
BP 874
EP 885
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA P4ZN1
UT WOS:001050762600018
DA 2026-05-27
ER

PT J
AU Wang, XP
   Zhang, ZD
   Cao, XL
AF Wang, Xiaoping
   Zhang, Zhendong
   Cao, Xiaolan
TI Salidroside inhibited the proliferation of gastric cancer cells through
   up-regulating tumor suppressor miR-1343-3p and down-regulating
   MAP3K6/MMP24 signal molecules
SO CANCER BIOLOGY & THERAPY
LA English
DT Article
DE Salidroside; gastric cancer cell; microRNA (miRNA); proliferation;
   signal molecules
ID MATRIX METALLOPROTEINASES; MIGRATION; IDENTIFICATION; PROGELATINASE;
   APOPTOSIS; PROFILES; INVASION; GROWTH
AB Salidroside inhibited the proliferation of cancer cell. Nevertheless, the mechanism has not been completely clarified. The purpose of the study is to explore the mechanisms of salidroside against gastric cancer. To analyze the changes of microRNA (miRNA) in gastric cancer cells under the treatment of salidroside, the miRNA expression was analyzed by using RNA-seq in cancer cells for 24 h after salidroside treatment. The differentially expressed miRNAs were clustered and their target genes were analyzed. Selected miRNA and target mRNA genes were further verified by q-PCR. The expressions of target genes in cancer cells were detected by immunohistochemistry. Cancer cell apoptotic index was significantly increased after salidroside treatment. The proliferation of gastric cancer cells were blocked at S-phase cell cycle. The expression of 44 miRNAs changed differentially after salidroside treatment in cancer cells. Bioinformatic analysis showed that there were 1384 target mRNAs corresponding to the differentially expressed miRNAs. Surprisingly, salidroside significantly up-regulated the expression of tumor suppressor miR-1343-3p, and down-regulated the expression of MAP3K6, STAT3 and MMP24-related genes. Salidroside suppressed the growth of gastric cancer by inducing the cancer cell apoptosis, arresting the cancer cell cycle and down-regulating the related signal transduction pathways. miRNAs are expressed differentially in gastric cancer cells after salidroside treatment, playing important roles in regulating proliferation and metastasis. Salidroside may suppress the growth of gastric cancer by up-regulating the expression of the tumor suppressor miR-1343-3p and down-regulating the expression of MAP3K6 and MMP24 signal molecules.
C1 [Wang, Xiaoping; Zhang, Zhendong; Cao, Xiaolan] Xizang Minzu Univ, Dept Med, Key Lab High Altitude Hypoxia Environm & Life Hlth, Xianyang, Shaanxi, Peoples R China.
   [Wang, Xiaoping] Xizang Minzu Univ, Dept Med, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
C3 Xizang Minzu University; Xizang Minzu University
RP Wang, XP (corresponding author), Xizang Minzu Univ, Dept Med, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
EM xpwang@xzmu.edu.cn
OI wang, xiaoping/0000-0001-9856-4549
FU National Natural Science Foundation of China [81172135]; Key Scientific
   Research Program of Xizang Autonomous Region and Xizang Minzu University
   [XZ202101ZR0074G, 20MDT02]; Graduate research and innovation projects
   [Y2024002, Y2024005]; Research project of Chunhui plan of Ministry of
   Education of China [202070310]; Natural Science Basic Research Plan in
   Shaanxi Province of China [2020JM- 590, 2022JM-465]
FX This work is supported by the National Natural Science Foundation of
   China [No. 81172135], Key Scientific Research Program of Xizang
   Autonomous Region and Xizang Minzu University [No. XZ202101ZR0074G and
   No.20MDT02], Graduate research and innovation projects [No. Y2024002,
   Y2024005], Research project of Chunhui plan of Ministry of Education of
   China [No. 202070310] and the Natural Science Basic Research Plan in
   Shaanxi Province of China [No.2020JM- 590, 2022JM-465].
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NR 45
TC 19
Z9 24
U1 5
U2 36
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1538-4047
EI 1555-8576
J9 CANCER BIOL THER
JI Cancer Biol. Ther.
PD DEC 31
PY 2024
VL 25
IS 1
AR 2322206
DI 10.1080/15384047.2024.2322206
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KD7W7
UT WOS:001178096600001
PM 38436092
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, BC
   Li, WM
   Guo, R
   Xu, YW
AF Zhang, Bu-Chun
   Li, Wei-Ming
   Guo, Rong
   Xu, Ya-Wei
TI Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density
   Lipoprotein Receptor-Deficient Mice
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INFLAMMATION; EXTRACT; INSIGHTS
AB Salidroside is isolated from Rhodiola rosea and is one of the main active components in Rhodiola species. The present study was designed to evaluate the effects of Salidroside on atherosclerotic plaque formation in high-fat diet-(HFD-) fed female LDL receptor knockout (LDLr-/-) mice. LDLr-/- mice fed an atherogenic HFD for 12 weeks were divided into two groups. One group was administered Salidroside (50 mg/kg/oral gavage) daily for 8 weeks, while the control group was administered saline. Salidroside treatment reduced serum lipids levels and the plaque area through the arch to the abdominal aorta. Furthermore, Salidroside improved macrophage content and enhanced collagen and smooth muscle cells contents in the aortic sinus. These changes were associated with reduced MCP-1, VCAM-1, and VCAM-1 protein expression in atherosclerotic aortas. All these results suggest that Salidroside decreases atherosclerotic plaques formation via effects on lipid lowering and anti-inflammation in HFD-fed LDLr-/- mice.
C1 [Zhang, Bu-Chun; Li, Wei-Ming; Guo, Rong; Xu, Ya-Wei] Tongji Univ, Sch Med, Dept Cardiol, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China.
C3 Tongji University
RP Xu, YW (corresponding author), Tongji Univ, Sch Med, Dept Cardiol, Shanghai Peoples Hosp 10, 301 Yanchang Rd, Shanghai 200072, Peoples R China.
EM xuyaweish@gmail.com
FU National Natural Science Foundation of China [81200198]; Shanghai
   Municipal Health Bureau; Shanghai Tenth People's Hospital
FX This research was supported by the National Natural Science Foundation
   of China (Grant no. 81200198), a grant to Dr. B. C. Zhang funded by
   Shanghai Municipal Health Bureau research projects (2012) and young
   talents training program of Shanghai Tenth People's Hospital (2012).
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NR 12
TC 37
Z9 38
U1 0
U2 23
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 607508
DI 10.1155/2012/607508
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 023FW
UT WOS:000310019300001
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wu, MZ
   Hu, R
   Wang, JW
   An, Y
   Lu, L
   Long, C
   Yan, L
AF Wu, Mingzheng
   Hu, Rui
   Wang, Junwen
   An, Ying
   Lu, Lin
   Long, Chao
   Yan, Li
TI Salidroside Suppresses IL-1β-Induced Apoptosis in Chondrocytes via
   Phosphatidylinositol 3-Kinases (PI3K)/Akt Signaling Inhibition
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Apoptosis; Chondrocytes; Phosphatidylinositol 3-Kinases
ID INFLAMMATION; CELLS
AB Background: Salidroside, a natural dietary isothiocyanate, has been widely studied for its multiple effects, including promot- ing proliferation, anti-inflammation, and anti-apoptosis. In the present study, these effects of Salidroside were explored to assess whether it could prevent osteoarthritis (OA) in vitro.
   Material/Methods: The cytotoxic and proliferating effects of Salidroside on chondrocytes were detected by use of the Cell Counting Kit 8 assay. The expression levels of proteins were detected by Western blot. The cell apoptosis level was assessed by flow cytometry, and the levels of ROS, NO, caspase 3, and caspase 9 were assessed to evaluate the level of apoptosis. The expression level of pro-inflammatory factors was detected by ELISA.
   Results: Our results demonstrated that Salidroside promotes chondrocytes proliferation, inhibits IL-1 beta-induced apoptosis and inflammation, and scavenges reactive oxygen species (ROS) and NO of chondrocytes. Salidroside upregulates the level of Bcl-2 and downregulates the level of Bax. Salidroside also inhibits the production of caspase 3/9 and suppresses the phosphorylation of PI3K and AKT.
   Conclusions: Our results suggest that Salidroside prevents OA by its powerful pro-proliferating, anti-phlogistic, and anti- apoptotic effects by inhibiting PI3K/AKT.
C1 [Wu, Mingzheng; Hu, Rui; Wang, Junwen; An, Ying; Lu, Lin; Long, Chao; Yan, Li] Huazhong Univ Sci & Technol, Dept Orthoped, Pulai Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Yan, L (corresponding author), Huazhong Univ Sci & Technol, Dept Orthoped, Pulai Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
EM 79878198@qq.com
OI Wu, Mingzheng/0000-0001-8282-4510
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NR 23
TC 22
Z9 27
U1 0
U2 15
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD AUG 5
PY 2019
VL 25
BP 5833
EP 5840
DI 10.12659/MSM.917851
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IO1AF
UT WOS:000479111300003
PM 31381554
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wang, JM
   Song, GH
   Hussain, L
   Xing, LL
AF Wang, Jianmin
   Song, Guanghui
   Hussain, Liaqat
   Xing, Lili
TI Deciphering the pharmacological mechanisms of salidroside in cervical
   cancer by combining network pharmacology, molecular docking, and in
   vitro studies
SO SAUDI PHARMACEUTICAL JOURNAL
LA English
DT Article
DE Salidroside; Cervical cancer; Network pharmacology;
   <italic>MMP</italic>1; <italic>MMP3</italic>; Apoptosis
ID MATRIX METALLOPROTEINASES; CURCUMIN
AB Cervical cancer is one of the major and serious risks to women. Salidroside, a natural compound, shows promise in treating cervical cancer. However, its specific molecular mechanisms remain unclear and require further investigation. This study aimed to elucidate the pharmacological activity of salidroside and its underlying molecular mechanisms in cervical cancer, employing network pharmacology, molecular docking, and experimental approaches. Genes associated with cervical cancer were gathered from The Cancer Genome Atlas Program (TCGA), Gene Expression Omnibus (GEO) databases, and network pharmacology. Furthermore, we integrated the drug targets with the disease targets pertinent to cervical cancer, subsequently conducting analyses utilizing the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) to explain the pharmacological pathways through which salidroside operates in the milieu of cervical cancer. Survival analysis was performed to screen the core therapeutic targets of salidroside. Salidroside constituents and hub genes binding affinity were assessed by molecular docking studies. In vitro experiments, including Cell Counting Kit-8 (CCK-8) assays, flow cytometry, and western blotting, were performed to further validate the computational findings. Study findings revealed that salidroside inhibited the cervical cancer cell progression, reduced viability, and induced apoptosis.Ten target genes related to salidroside's anti-cancer effects have been identified. Survival analysis revealed that MMP1 and MMP3 exhibited the highest binding capability among all the target genes. Molecular docking indicated that the salidroside's active entities showed a strong binding tendency with the MMP1 and MMP3 genes. Western blot analysis revealed that it significantly reduced the expression of MMP-1 and MMP-3. In Vitro studies suggested that suppressing MMP1 and MMP3 genes might be responsible for salidroside's anticancer effects.
C1 [Wang, Jianmin; Song, Guanghui] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Obstet & Gynecol,Sch Med, Key Lab Reprod Dysfunct Management Zhejiang Prov, Hangzhou 310016, Peoples R China.
   [Hussain, Liaqat] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmacol, Faisalabad 38000, Pakistan.
   [Xing, Lili] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Ctr Reprod Med, Dept Reprod Endocrinol, Hangzhou 310014, Peoples R China.
C3 Zhejiang University; Government College University Faisalabad; Hangzhou
   Medical College; Zhejiang Provincial People's Hospital
RP Hussain, L (corresponding author), Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmacol, Faisalabad 38000, Pakistan.; Xing, LL (corresponding author), Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Ctr Reprod Med, Dept Reprod Endocrinol, Hangzhou 310014, Peoples R China.
EM liaqat.hussain@gcuf.edu.pk; xinglili@hmc.edu.cn
RI HUSSAIN, LIAQAT/L-9974-2019; GUANGHUI, SONG/PII-2902-2026
OI HUSSAIN, LIAQAT/0000-0001-7171-5917; 
FU Medical Technology and Education of Zhejiang Province of China
   [Y202043619]; Zhejiang Province Public Welfare Technology Application
   Research Project [2022KY57]
FX This work was supported by the following projects: a General Research
   Project from the Department of Education of Zhejiang Province in 2020
   (Y202043619) and a Clinical Research Application Project from the Health
   Commission of Zhejiang Province in 2022(2022KY577).
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NR 38
TC 0
Z9 0
U1 3
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1319-0164
EI 2213-7475
J9 SAUDI PHARM J
JI Saudi Pharm. J.
PD DEC 15
PY 2025
VL 33
IS 6
AR 49
DI 10.1007/s44446-025-00052-0
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA W1966
UT WOS:001639359200001
PM 41396408
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, XP
   Kou, YB
   Lu, YS
   Pu, YM
AF Chen, Xiaoping
   Kou, Yubin
   Lu, Yunsong
   Pu, Yumei
TI Salidroside ameliorated hypoxia-induced tumorigenesis of BxPC-3 cells
   via downregulating hypoxia-inducible factor (HIF)-1α and LOXL2
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE BxPC-3 cells; HIF-1 alpha; LOXL2; pancreatic cancer; salidroside
ID COLORECTAL-CANCER; PANCREATIC-CANCER; METASTASIS; INVASION; CADHERIN
AB Herein, we found that salidroside suppressed hypoxia-inducible factor 1 alpha (HIF-1 alpha) and lysyl oxidase-like protein 2 (LOXL2) within human pancreatic cancer BxPC-3 cells cultured both under normoxia and hypoxia condition. To investigate the effect of salidroside on tumorigenesis of BxPC-3 cells and whether HIF-1 alpha and LXCL2 were involved in this process, cells transfected with or without LOXL2 overexpression vector, were treated with 50 mu g/mL of salidroside or 50 mu M of KC7F2 (a HIF-1 alpha inhibitor) under hypoxia. Cell viability and invasion were assessed using CCK-8 and Transwell chamber assay, respectively. Expression of E-cadherin and matrix metalloproteinase 2/9 (MMP 2/9) was determined, by Western blot analysis, to assess cell mobility at molecular levels. We confirmed that hypoxia increased LOXL2 and induced tumorigenesis of BxPC-3 cells, as evidenced by promoted cell proliferation and invasion, enhanced MMP2/9 while reduced E-cadherin. Interestingly, hypoxia-induced carcinogenesis was significantly retarded by both salidroside and KC7F2, however, enhanced with LOXL2 overexpression. Besides, salidroside and KC7F2 reduced LOXL2, and reversed the tumorigenesis of BxPC-3 cells induced by LOXL2 overexpression. Given the inhibitory effect of salidroside on HIF-1 alpha expression, our data suggested that: (1) LOXL2 was the mechanism, whereby salidroside and KC7F2 showed inhibitory effect on cancer progression of BxPC-3 cells; (2) salidroside exerted its anticancer effect, most likely, by a HIF-1 alpha/LOXL2 pathway. In conclusion, salidroside was a novel therapeutic drug in pancreatic cancer, and downregulation of HIF-1 alpha and LXCL2 was the underlying mechanism.
C1 [Chen, Xiaoping; Kou, Yubin; Lu, Yunsong] Shanghai Univ Tradit Chinese Med, Dept Biliary & Pancreat Surg, Baoshan Branch, Shuguang Hosp, 181 Youyi Rd, Shanghai 201900, Peoples R China.
   [Pu, Yumei] Shanghai Skin Dis Hosp, Dept Hepatol, 1278 Baode Rd, Shanghai 200443, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Chen, XP (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Biliary & Pancreat Surg, Baoshan Branch, Shuguang Hosp, 181 Youyi Rd, Shanghai 201900, Peoples R China.; Pu, YM (corresponding author), Shanghai Skin Dis Hosp, Dept Hepatol, 1278 Baode Rd, Shanghai 200443, Peoples R China.
EM jade6610@126.com; puyumwi88@sina.com
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NR 27
TC 22
Z9 28
U1 2
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD JAN
PY 2020
VL 121
IS 1
BP 165
EP 173
DI 10.1002/jcb.29000
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JQ1VC
UT WOS:000498739700016
PM 31162697
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Du, Y
   Chen, ZX
   Liang, F
   Zhou, WJ
   Tu, ZX
   Zhang, X
   Wang, ZX
   Li, J
AF Du, Yan
   Chen, Zhengxing
   Liang, Feng
   Zhou, Wenju
   Tu, Zhaoxin
   Zhang, Xin
   Wang, Zexu
   Li, Juan
TI Effects of salidroside on functional and structural changes in highland
   barley proteins
SO LWT-FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Highland barley; Non-covalent interactions; Conformational changes;
   Antioxidant ability
ID EMULSIFYING PROPERTIES; COVALENT MODIFICATION; TEA POLYPHENOLS; WHEY
   PROTEINS; ACID; BINDING; ISOLATE
AB This study investigates the functional and conformational changes in highland barley proteins (HBPs)-salidroside complexes formed by non-covalent bond interactions. The free sulfhydryl contents of HBPs are decreased from 37.65 +/- 1.90 mu mol/g protein to 18.86 +/- 0.14 mu mol/g protein after binding with salidroside. The fluorescence spectroscopy show that two fluorescence peaks are observed and salidroside enhance the fluorescence intensity of HBPs at the high addition level of salidroside (0.5-1 mmol/g protein). Secondary structure, surface hydrophobicity, and Zeta potential of HBPs are also changed by salidroside with different addition level (0-1 mmol/g protein). HBPs-salidroside complexes exhibit better functional properties (emulsifying and foaming properties) than HBPs, which is probably due to conformational changes in the HBPs. The combination of HBPs and salidroside increase the antioxidant ability of HBPs. Overall, salidroside has the potential to improve the structural characteristics and functional properties of HBPs, especially their antioxidant ability.
C1 [Du, Yan; Chen, Zhengxing; Liang, Feng; Li, Juan] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Du, Yan; Chen, Zhengxing; Liang, Feng; Zhang, Xin; Wang, Zexu; Li, Juan] Jiangnan Univ, Natl Engn Res Ctr Cereal Fermentat & Food Biomfg, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhou, Wenju; Tu, Zhaoxin] Qinghai Huashi Technol Investment Management Co L, Qinghai Engn Technol Res Inst Comprehens Utilizat, Xining 810016, Qinghai, Peoples R China.
   [Chen, Zhengxing; Li, Juan] Jiangnan Univ, Jiangsu Prov Engn Res Ctr Bioact Prod Proc, Wuxi 214122, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University
RP Li, J (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
EM juanli@jiangnan.edu.cn
RI Liang, Feng/JHT-7449-2023; Wang, Zexu/OYF-5805-2025
FU Qinghai Provincial Science and Technology Basic Research Program, China
   [2021-ZJ-712]; Xining Science and Technology Planning Program, China
   [2020-Y-15, 2021-Y-11]
FX Acknowledgments This research was supported by Qinghai Provincial
   Science and Technology Basic Research Program, China (2021-ZJ-712) and
   Xining Science and Technology Planning Program, China (2020-Y-15,
   2021-Y-11) .
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NR 45
TC 15
Z9 17
U1 1
U2 70
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0023-6438
EI 1096-1127
J9 LWT-FOOD SCI TECHNOL
JI LWT-Food Sci. Technol.
PD APR 15
PY 2022
VL 160
AR 113310
DI 10.1016/j.lwt.2022.113310
EA MAR 2022
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0L3DZ
UT WOS:000781359700002
OA gold
DA 2026-05-27
ER

PT J
AU Wang, N
   Gao, ZS
   Zhan, HH
   Jing, L
   Meng, FC
   Chen, M
AF Wang, Nan
   Gao, Zhengshan
   Zhan, Honghong
   Jing, Lin
   Meng, Fancheng
   Chen, Min
TI Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/
   AMPK-mediated pyroptotic inhibition
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Salidroside; Doxorubicin; Hepatotoxicity; Pyroptosis; Mitochondrial
   dysfunction; Endoplasmic reticulum stress
ID ENDOPLASMIC-RETICULUM STRESS; MITOCHONDRIAL-FUNCTION; TOXICITY; DAMAGE;
   ALPHA
AB Doxorubicin (DOX) is a potent anticancer drug, while its toxic side effects involve multi-organ toxicity, including hepatotoxicity. This study aims to investigate the therapeutic potential of salidroside against DOX-induced hepatotoxicity and elucidate its underlying mechanisms. Result showed that salidroside exhibited a liver protective effect in DOX-induced hepatotoxicity in mice, represented by the decreased serum ALT, AST and LDH levels, as well as the rescue of pathological changes in mice livers. Further study showed salidroside reduced the expression level of pyroptosis-associated proteins, including NLRP3, cleaved-caspase 1, gasdermin D (GSDMD-N) and mature IL-1(3 in mice liver tissues. In vitro study confirmed salidroside exerted a similar effect in AML12 cells. Mechanistically, salidroside alleviated mitochondrial dysfunction by activating the PGC-1 alpha/Mfn2 signaling pathway, and restrained the endoplasmic reticulum (ER) stress, represented by the downregulation of GRP78 and p-PERK/PERK level. Subsequent investigations revealed that salidroside activated the Sestrin2/AMPK pathway, while the application of AMPK inhibitors, PGC-1 alpha siRNA or Sestrain2 siRNA reversed the effects of salidroside on ameliorating mitochondrial dysfunction and ER stress, suggesting salidroside could be a promising therapeutic strategy for alleviating DOX-induced hepatotoxicity.
C1 [Wang, Nan; Gao, Zhengshan; Zhan, Honghong; Jing, Lin; Meng, Fancheng; Chen, Min] Southwest Univ, Coll Pharmaceut Sci, Integrat Sci Ctr Germplasm Creat Western China Cho, Chongqing Key Lab New Drug Screening Tradit Chines, Chongqing 400715, Peoples R China.
   [Wang, Nan; Gao, Zhengshan; Zhan, Honghong; Jing, Lin; Meng, Fancheng; Chen, Min] Southwest Univ, Coll Pharmaceut Sci, SWU TAAHC Med Plant Joint R&D Ctr, Chongqing 400715, Peoples R China.
   [Wang, Nan] Chongqing Med & Pharmaceut Coll, Chongqing Key Lab High Act Tradit Chinese Drug Del, Chongqing 401331, Peoples R China.
   [Chen, Min] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
C3 Southwest University - China; Southwest University - China; Chengdu
   University of Traditional Chinese Medicine
RP Chen, M (corresponding author), Southwest Univ, Coll Pharmaceut Sci, 2 Tiansheng Rd, Chongqing 400715, Peoples R China.
EM mminchen@swu.edu.cn
RI ; Meng, FanCheng/IAO-5364-2023
OI Chen, Min/0000-0002-0140-4192; 
FU National Natural Science Foundation of China [82274202]; Open Fund from
   State Key Laboratory of Southwestern Chinese Medicine Resources
   [SKLTCM202205]; Opening Foundation of Chongqing Key Labora-tory of High
   Active Traditional Chinese Drug Delivery System [kfkt202301]
FX This work was supported by National Natural Science Foundation of China
   (grant number 82274202) , Open Fund from State Key Laboratory of
   Southwestern Chinese Medicine Resources (grant number SKLTCM202205) and
   Opening Foundation of Chongqing Key Labora-tory of High Active
   Traditional Chinese Drug Delivery System (grant number kfkt202301) .
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NR 40
TC 5
Z9 5
U1 2
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAY
PY 2025
VL 199
AR 115335
DI 10.1016/j.fct.2025.115335
EA FEB 2025
PG 14
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA Z2C7D
UT WOS:001437057500001
PM 39993461
DA 2026-05-27
ER

PT J
AU Hong, Y
   Li, YR
   Liu, X
   Deng, J
   He, YL
   Zhao, B
AF Hong, Ye
   Li, Yanrong
   Liu, Xia
   Deng, Jia
   He, Yanli
   Zhao, Bin
TI Salidroside inhibits the invasion and migration of colorectal cancer
   cells by regulating MMP-12 and WNT signaling pathway
SO AMERICAN JOURNAL OF CANCER RESEARCH
LA English
DT Article
DE Salidroside; colon cancer; MMP-12; WNT signaling pathway; invasion;
   migration
ID EPITHELIAL-MESENCHYMAL TRANSITION; COLON-CANCER; PROLIFERATION
AB Colorectal cancer (CRC) is a prevalent and highly lethal malignancy, with current therapeutic efficacy limited by the tumor's high invasiveness and metastatic potential. Matrix metalloproteinases (MMPs) and the WNT (Wingless/Integrated) signaling pathway play key roles in the invasion and metastasis of CRC. Salidroside, a natural compound, has demonstrated inhibitory effects in several cancers, but its precise molecular mechanism in CRC cells remains unclear. This study aims to investigate the antitumor effect of salidroside on CRC and its molecular mechanism in influencing epithelial-mesenchymal transition (EMT) by regulating MMP-12 and the WNT signaling pathway. The effects of salidroside on CRC cell proliferation, migration, and invasion were evaluated through in vitro experiments using HCT-116 and SW620 cell lines. The antitumor effects of salidroside were validated using CCK-8, wound healing, and Transwell assays. Expression changes of MMP-12, WNT signaling-related proteins (e.g., (3-catenin, GSK-3(3), and EMT markers (e.g., E-cadherin, Vimentin) after salidroside treatment were measured by qRT-PCR and Western Blot. Additionally, bioinformatics analysis was performed using TCGA and GEO databases in combination with the BEST online tool to identify differentially expressed genes, followed by GSEA enrichment analysis. Salidroside showed significant antiproliferative and inhibitory effects on the migration and invasion of CRC cells. In vitro experiments demonstrated that salidroside significantly inhibited CRC cell proliferation and reduced their migration and invasion capabilities. qRT-PCR and Western Blot analyses showed that salidroside significantly downregulated MMP-12 expression and led to changes in the expression of WNT signaling and EMT-related proteins, specifically downregulating (3-catenin, upregulating E-cadherin, and downregulating Vimentin. Furthermore, bioinformatics analysis indicated that MMP-12 plays a crucial role in salidroside-mediated CRC inhibition, further supporting its potential as a key target. In conclusion, salidroside suppresses CRC invasion and migration by downregulating MMP-12 and modulating the WNT signaling pathway, thereby inhibiting the EMT process. These findings suggest that salidroside holds potential as a therapeutic agent for CRC, offering a novel approach to CRC treatment.
C1 [Hong, Ye; Li, Yanrong] Shaanxi Prov Canc Hosp, Ctr Digest Endoscopy, 309 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Liu, Xia] Baoji Peoples Hosp, Dept Gastroenterol, 24 Xinhua Lane,Jing Er Rd, Baoji 721000, Shaanxi, Peoples R China.
   [Deng, Jia] Shaanxi Prov Canc Hosp, Dept Radiat Oncol, 309 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Deng, Jia] Xi An Jiao Tong Univ, Sch Nucl Sci & Technol, 28 Xianning West Rd, Xian 710049, Shaanxi, Peoples R China.
   [He, Yanli] Shaanxi Prov Canc Hosp, Dept Integrated Chinese & Western Med, 309 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Zhao, Bin] Shaanxi Prov Canc Hosp, Dept Epidemiol, 309 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Zhao, Bin] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ, 28 Xianning West Rd, Xian 710049, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Zhao, B (corresponding author), Shaanxi Prov Canc Hosp, Dept Epidemiol, 309 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM billness@stu.xjtu.edu.cn
FU Shaanxi Provincial Key RD Program [2024SF-YBXM-133]; Shaanxi Provincial
   Health Commission [2021B007]
FX This work was supported by Shaanxi Provincial Key R&D Program (No.
   2024SF-YBXM-133) and Shaanxi Provincial Health Commission, No 2021B007.
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NR 34
TC 5
Z9 5
U1 1
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 2156-6976
J9 AM J CANCER RES
JI Am. J. Cancer Res.
PY 2025
VL 15
IS 3
DI 10.62347/KELA7583
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2BZ8G
UT WOS:001479045400005
PM 40226472
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Guan, S
   Xiong, Y
   Song, BC
   Song, Y
   Wang, DC
   Chu, X
   Chen, N
   Huo, MX
   Deng, XM
   Lu, J
AF Guan, Shuang
   Xiong, Ying
   Song, Bocui
   Song, Yu
   Wang, Dacheng
   Chu, Xiao
   Chen, Na
   Huo, Meixia
   Deng, Xuming
   Lu, Jing
TI Protective effects of salidroside from Rhodiola rosea on
   LPS-induced acute lung injury in mice
SO IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
LA English
DT Article
DE Salidroside; protective; LPS; ALI
ID INFLAMMATORY RESPONSE; L. EXTRACT; IN-VITRO; LIPOPOLYSACCHARIDE;
   ENDOTOXIN; STRESS; RATS
AB Salidroside is a major component extracted from Rhodiola rosea. In this study, we investigated protective effects of salidroside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. In the mouse model, we found that pretreatment with a single 120 mg/kg dose of salidroside prior to the administration of intratracheal LPS induced a significant decrease in the W/D ratio and mouse myeloperoxidase activity of lung, reduction protein concentration, the number of total cells, neutrophils and macrophages in the bronchoalveolar lavage fluid. In addition, salidroside also inhibited the production of several inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-6 (IL-6) and IL-1 beta,and the NF-kappa B DNA-binding activation after LPS challenge. These results indicated that salidroside possess a protective effect on LPS-induced ALI in mice.
C1 [Guan, Shuang; Xiong, Ying; Song, Bocui; Song, Yu; Wang, Dacheng; Chu, Xiao; Chen, Na; Huo, Meixia; Deng, Xuming; Lu, Jing] Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China.
   [Guan, Shuang; Lu, Jing] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Deng, XM (corresponding author), Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China.
EM xumingdeng@yahoo.com.cn; xlujing1@yahoo.com.cn
RI wang, dacheng/OLQ-7846-2025; Song, Yuxiang/F-1446-2019; Xiong,
   Yingzhu/LOR-2049-2024; Guan, Shuang/JXN-9245-2024
FU National Nature Science Foundation of China [30972212]
FX This study was financed by the National Nature Science Foundation of
   China (No. 30972212).
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NR 28
TC 53
Z9 63
U1 0
U2 38
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0892-3973
EI 1532-2513
J9 IMMUNOPHARM IMMUNOT
JI Immunopharmacol. Immunotoxicol.
PD AUG
PY 2012
VL 34
IS 4
BP 667
EP 672
DI 10.3109/08923973.2011.650175
PG 6
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA 971VJ
UT WOS:000306231900017
PM 22776035
DA 2026-05-27
ER

PT J
AU Liu, YY
   Lei, ZL
   Chai, H
   Kang, Q
   Qin, XY
AF Liu, Yanyao
   Lei, Zilun
   Chai, Hao
   Kang, Quan
   Qin, Xiaoyan
TI Salidroside alleviates hepatic ischemia-reperfusion injury during liver
   transplant in rat through regulating TLR-4/NF-κB/NLRP3 inflammatory
   pathway
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ISCHEMIA/REPERFUSION INJURY; KAPPA-B; FAILURE; NLRP3
AB Salidroside has anti-inflammatory, antioxidant and hepatoprotective properties. However, its effect on hepatic ischemia-reperfusion injury (IRI), an unavoidable side effect associated with liver transplantation, remains undefined. Here, we aimed to determine whether salidroside alleviates hepatic IRI and elucidate its potential mechanisms. We used both in vivo and in vitro assays to assess the effect and mechanisms of salidroside on hepatic IRI. Hepatic IRI rat models were pretreated with salidroside (5, 10 or 20 mg/kg/day) for 7 days following liver transplantation while hypoxia/reoxygenation (H/R) model of RAW 264.7 macrophages were pretreated with salidroside (1, 10 or 50 mu M). The effect of salidroside on hepatic IRI was assessed using hematoxylin-eosin staining, terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, qRT-PCR, immunosorbent assay and western blotting. Our in vivo assays showed that salidroside significantly reduced pathological liver damage, serum aminotransferase levels and serum levels of IL-1, IL-18 and TNF-alpha. Besides, salidroside reduced the expression of TLR-4/NF-kappa B/NLRP3 inflammatory pathway associated proteins (TLR-4, MyD88, p-IKK alpha, p-IKK beta, p-IKK, p-I kappa B alpha, p-P65, NLRP3, ASC, Cleaved caspase-1, IL-1 beta, IL-18, TNF-alpha and IL-6) in rats after liver transplantation. On the other hand, data from the in vitro analysis demonstrated that salidroside blocks expression of TLR-4/NF-kappa B/NLRP3 inflammatory pathway related proteins in the RAW264.7 cells treated with H/R. The salidroside-specific anti-inflammatory effects were partially inhibited by the TLR-4 agonist lipopolysaccharide. Taken together, our study showed that salidroside inhibits hepatic IRI following liver transplantation by modulating the TLR-4/NF-kappa B/NLRP3 inflammatory pathway.
C1 [Liu, Yanyao; Kang, Quan; Qin, Xiaoyan] Chongqing Med Univ, Childrens Hosp,Chongqing Key Lab Pediat, Dept Gen Surg & Trauma Surg,China Int Sci & Techn, Minist Educ,Key Lab Child Dev & Disorders,Natl Cl, Chongqing, Peoples R China.
   [Liu, Yanyao; Lei, Zilun; Chai, Hao] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Qin, XY (corresponding author), Chongqing Med Univ, Childrens Hosp,Chongqing Key Lab Pediat, Dept Gen Surg & Trauma Surg,China Int Sci & Techn, Minist Educ,Key Lab Child Dev & Disorders,Natl Cl, Chongqing, Peoples R China.
EM qinxiaoyan1995@sina.com
RI liu, yanyao/HMW-2633-2023; Qin, Xiaoyan/KLZ-0501-2024
FU National Natural Science Foundation of Chongqing
   [cstc2020jcyj-msxmX0113]
FX This work was supported by the National Natural Science Foundation of
   Chongqing (No. cstc2020jcyj-msxmX0113).
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NR 35
TC 26
Z9 30
U1 0
U2 28
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 17
PY 2022
VL 12
IS 1
AR 13973
DI 10.1038/s41598-022-18369-4
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3W1XA
UT WOS:000842145300053
PM 35978104
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shi, K
   Wang, XL
   Zhu, J
   Cao, GQ
   Zhang, K
   Su, ZG
AF Shi, Kai
   Wang, Xulei
   Zhu, Jie
   Cao, Guiqun
   Zhang, Kang
   Su, Zhiguang
TI Salidroside protects retinal endothelial cells against hydrogen
   peroxide-induced injury via modulating oxidative status and apoptosis
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE retinal endothelial cells; hydrogen peroxide; apoptosis; oxidative
   stress; salidroside
ID CARDIOVASCULAR-DISEASE; STRESS; MITOCHONDRIA; ANTIOXIDANTS; DEATH; RAT
AB Oxidative stress can cause injury in retinal endothelial cells. Salidroside is a strong antioxidative and cytoprotective supplement in Chinese traditional medicine. In this study, we investigated the effects of salidroside on H2O2-induced primary retinal endothelial cells injury. Salidroside decreased H2O2-induced cell death, and efficiently suppressed cellular ROS production, malondialdehyde generation, and cell apoptosis induced by H2O2 treatment. Salidroside induced the intracellular mRNA expression, protein expression, and enzymatic activities of catalase and Mn-SOD and increased the ratio of Bcl2/Bax. Our results demonstrated that salidroside protected retinal endothelial cells against oxidative injury through increasing the Bcl2/Bax signaling pathway and activation of endogenous antioxidant enzymes. This finding presents salidroside as an attractive agent with potential to attenuate retinopathic diseases.
C1 [Shi, Kai; Zhang, Kang] Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu, Peoples R China.
   [Shi, Kai; Wang, Xulei; Cao, Guiqun; Zhang, Kang; Su, Zhiguang] Sichuan Univ, West China Hosp, Mol Med Res Ctr, State Key Lab Biotherapy, Chengdu, Peoples R China.
   [Zhu, Jie] Fourth Mil Med Univ, Xijing Hosp, Dept Ophthalmol, Xian 710032, Peoples R China.
   [Zhang, Kang] Univ Calif San Diego, Dept Ophthalmol, San Diego, CA 92103 USA.
   [Zhang, Kang] Univ Calif San Diego, Shiley Eye Ctr, San Diego, CA 92103 USA.
C3 Sichuan University; Sichuan University; Air Force Medical University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Su, ZG (corresponding author), Sichuan Univ, West China Hosp, Mol Med Res Ctr, State Key Lab Biotherapy, Chengdu, Peoples R China.
EM zhiguang.su@scu.edu.cn
RI Zhu, Jie/AAD-1330-2022; Su, Zhiguang/AFS-0022-2022; Zhang,
   Kang/Y-2740-2019; Wang, Xulei/OHR-7477-2025
OI Zhu, Jie/0000-0001-6862-9022; Su, Zhiguang/0000-0001-8635-9310; 
FU National High Technology Research and Development Program of China (863
   project) [2014AA021604]; Sichuan Province Science and Technology Support
   Program [2015SZ0140]
FX This work was supported by the National High Technology Research and
   Development Program of China (863 project) [grant number 2014AA021604];
   Sichuan Province Science and Technology Support Program [grant number
   2015SZ0140].
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NR 30
TC 24
Z9 27
U1 0
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD SEP 2
PY 2015
VL 79
IS 9
BP 1406
EP 1413
DI 10.1080/09168451.2015.1038212
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA CP4HR
UT WOS:000359843100003
PM 25921655
OA Bronze
DA 2026-05-27
ER

PT J
AU Mendjargal, A
   Narmandakh, S
   Zinamyadar, M
   Amartuvshin, E
   Bold, J
   Garmaa, N
   Sundui, E
   Dorjkhuu, A
   Amgalanbaatar, A
   Odkhuu, E
AF Mendjargal, Adilsaikhan
   Narmandakh, Shijir
   Zinamyadar, Munkhjargal
   Amartuvshin, Egshiglen
   Bold, Juramt
   Garmaa, Nandin
   Sundui, Enebish
   Dorjkhuu, Amgalanbaatar
   Amgalanbaatar, Avirmed
   Odkhuu, Erdenezaya
TI The inhibitory effect of salidroside on RANKL-induced osteoclast
   formation via NFκB suppression
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Article
DE Salidroside; <italic>Rhodiola rosea</italic>; Osteoclast; NFATc1
ID NUCLEAR-FACTOR; RECEPTOR ACTIVATOR; DOWN-REGULATION; MACROPHAGES;
   MEDICINE; LIGAND; CELLS
AB Bone fractures are a prevalent clinical issue, and recent studies highlighted the promising potential of natural bone healing agents in enhancing fracture repair and regeneration. The regulatory interaction mechanism between osteoblasts and osteoclasts is crucial for bone cell biology and bone disease. In Mongolian medicine, people have used the Rhodiola rosea (R. rosea) extract to accelerate bone healing in bone fractures. Salidroside is a bioactive compound of R. rosea. Salidroside is known to regulate bone metabolism and inhibit the activation of osteoclast cells, but how it affects the differentiation of osteoclasts is unknown. We examined the effect of R. rosea extract and its bioactive compound salidroside on the RANKL-induced osteoclast formation in RAW 264.7 cells. The present study observed that salidroside directly inhibits RANKL-induced TRAP-positive osteoclast formation. Immunoblotting analysis revealed that salidroside inhibited the expression of c-Fos and NFATc1, osteoclastogenic key transcription factors, by suppressing late activation of p65 NF kappa B. Further, the ethanol extracts of R. rosea significantly reduced the RANKL-induced osteoclasts in a dose-dependent manner. In conclusion, salidroside inhibits RANKL-induced osteoclast formation via suppressing the NF kappa B/c-Fos/NFATc1 signalling pathway. R. rosea, a primary source of salidroside, is helpful for bone healing via its inhibitory effect on osteoclast formation.
C1 [Mendjargal, Adilsaikhan] Mongolian Natl Univ Med Sci, Mongolia Japan Hosp, Bot Garden, Ulaanbaatar 13270, Mongolia.
   [Mendjargal, Adilsaikhan; Narmandakh, Shijir; Zinamyadar, Munkhjargal; Amartuvshin, Egshiglen; Bold, Juramt; Garmaa, Nandin; Sundui, Enebish; Dorjkhuu, Amgalanbaatar; Amgalanbaatar, Avirmed; Odkhuu, Erdenezaya] Mongolian Soc Human Anat, Ulaanbaatar, Mongolia.
   [Narmandakh, Shijir; Bold, Juramt; Garmaa, Nandin; Dorjkhuu, Amgalanbaatar; Amgalanbaatar, Avirmed; Odkhuu, Erdenezaya] Mongolian Natl Univ Med Sci, Sch Biomed, Dept Anat, Post 48-111,S Zorig St, Ulaanbaatar 14210, Mongolia.
   [Narmandakh, Shijir] Mongolian Natl Univ Med Sci, Grad Sch, Ulaanbaatar, Mongolia.
   [Zinamyadar, Munkhjargal; Sundui, Enebish] Ach Med Univ, Ach Int Hosp, Dept Morphol, Ulaanbaatar, Mongolia.
   [Amartuvshin, Egshiglen] Mongolian Natl Univ Med Sci, Sch Biomed, Ulaanbaatar, Mongolia.
   [Odkhuu, Erdenezaya] Mongolian Natl Univ Med Sci, Inst Biomed Sci, S Zorig St,Post 48-111, Ulaanbaatar 14210, Mongolia.
C3 Mongolian National University of Medical Sciences; Mongolian National
   University of Medical Sciences; Mongolian National University of Medical
   Sciences; Mongolian National University of Medical Sciences; Mongolian
   National University of Medical Sciences
RP Odkhuu, E (corresponding author), Mongolian Soc Human Anat, Ulaanbaatar, Mongolia.; Odkhuu, E (corresponding author), Mongolian Natl Univ Med Sci, Sch Biomed, Dept Anat, Post 48-111,S Zorig St, Ulaanbaatar 14210, Mongolia.; Odkhuu, E (corresponding author), Mongolian Natl Univ Med Sci, Inst Biomed Sci, S Zorig St,Post 48-111, Ulaanbaatar 14210, Mongolia.
EM erdenezaya@mnums.edu.mn
RI Odkhuu, Erdenezaya/LNP-3674-2024
OI Odkhuu, Erdenezaya/0000-0002-5731-0726; amgalanbaatar,
   avirmed/0000-0001-8282-4932
FU Sciences and Technology Supportive Fund, Mongolia National University of
   Medical Sciences [2020/1-16]
FX This work was supported by the Sciences and Technology Supportive Fund,
   Mongolia National University of Medical Sciences, under Grant #2020/1-16
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Z9 1
U1 3
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1071-2690
EI 1543-706X
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD JAN
PY 2025
VL 61
IS 1
BP 59
EP 66
DI 10.1007/s11626-024-00981-5
EA OCT 2024
PG 8
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA U8B8H
UT WOS:001346013100001
PM 39476282
DA 2026-05-27
ER

PT J
AU Zheng, T
   Yang, XY
   Li, WJ
   Wang, QB
   Chen, L
   Wu, D
   Bian, F
   Xing, SS
   Jin, S
AF Zheng, Tao
   Yang, Xiaoyan
   Li, Wenjin
   Wang, Qibin
   Chen, Li
   Wu, Dan
   Bian, Fang
   Xing, Shasha
   Jin, Si
TI Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver
   Disease via AMPK-Dependent TXNIP/NLRP3 Pathway
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID THIOREDOXIN-INTERACTING PROTEIN; NLRP3 INFLAMMASOME ACTIVATION;
   ELEMENT-BINDING PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; RAT
   MODEL; GLUCOSE; EXPRESSION; MECHANISM; NAFLD
AB Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2 diabetic C57BLKS/Lepr(db) (db/db) mice. The aim of the present study was to evaluate the therapeutic effect of salidroside on high-fat diet- (HFD-) induced nonalcoholic fatty liver disease (NAFLD) by investigating underlying mechanisms. Mice were fed with HFD or regular diet, randomly divided into two groups, and treated with salidroside or vehicle for 8 weeks. Then, biochemical analyses and histopathological examinations were conducted in vivo and in vitro. Salidroside administration attenuated HFD-induced obesity, blood glucose variability, and hepatic lipid deposition, markedly increasing insulin sensitivity in HFD mice. In addition, salidroside suppressed oxidative stress, thioredoxin-interacting protein (TXNIP) expression, and NLRP3 inflammasome activation in the liver. In cultured hepatocytes, salidroside dose dependently regulated lipid accumulation, reactive oxygen species (ROS) generation, and NLRP3 inflammasome activation as well as improved AMP-activated protein kinase (AMPK) activity and insulin sensitivity. The inhibition of AMPK activation by inhibitor or short interfering RNA (siRNA) resulted in the suppression of the beneficial effects of salidroside in hepatocytes. Our findings demonstrated that salidroside protects against NAFLD by improving hepatic lipid metabolism and NLRP3 inflammasome activation, and these actions are related to the regulation of the oxidative stress and AMPK-dependent TXNIP/NLRP3 pathways.
C1 [Zheng, Tao; Li, Wenjin; Wu, Dan; Bian, Fang; Xing, Shasha; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Inst Geriatr Med, Wuhan, Hubei, Peoples R China.
   [Zheng, Tao; Wang, Qibin; Chen, Li] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan, Hubei, Peoples R China.
   [Zheng, Tao; Yang, Xiaoyan; Li, Wenjin; Wu, Dan; Bian, Fang; Xing, Shasha; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med,Dept Pharmacol, Hubei Key Lab Drug Target Res & Pharmacodynam Eva, Wuhan, Hubei, Peoples R China.
   [Zheng, Tao; Wang, Qibin; Chen, Li] Xi An Jiao Tong Univ, Sch Med, Taihe Hosp, Shiyan, Hubei, Peoples R China.
   [Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Hubei University of
   Medicine; Huazhong University of Science & Technology; Xi'an Jiaotong
   University; Huazhong University of Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Inst Geriatr Med, Wuhan, Hubei, Peoples R China.; Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med,Dept Pharmacol, Hubei Key Lab Drug Target Res & Pharmacodynam Eva, Wuhan, Hubei, Peoples R China.; Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol, Wuhan, Hubei, Peoples R China.
EM jinsi@hust.edu.cn
RI xing, shasha/JFB-2393-2023; jin, si/KGK-5977-2024; Zheng,
   Tao/JOZ-1467-2023
OI jin, si/0000-0003-0727-6715; Zheng, Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81573432, 81703582,
   81470458, 81373413]; Ministry of Education of China [NCET-10-0409];
   Hubei Provincial Natural Science Foundation of China [2016CFB153]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81573432, 81703582, 81470458, and 81373413),
   Ministry of Education of China (NCET-10-0409), and Hubei Provincial
   Natural Science Foundation of China (2016CFB153).
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NR 55
TC 117
Z9 127
U1 2
U2 50
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 8597897
DI 10.1155/2018/8597897
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GP5JM
UT WOS:000440909700001
PM 30140371
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, J
   Dai, XK
   Wang, MW
   Song, J
   Long, XY
   Qian, Y
   Zhao, X
AF Zhang, Jing
   Dai, Xiankun
   Wang, Mengwei
   Song, Jing
   Long, Xingyao
   Qian, Yu
   Zhao, Xin
TI SALIDROSIDE ENHANCES AEROBIC SWIMMING TO IMPROVE OXIDATIVE AGING INDUCED
   BY D-GALACTOSE IN MICE
SO ACTA POLONIAE PHARMACEUTICA
LA English
DT Article
DE salidroside; aerobic swimming; oxidative aging; D-galactose; expression
ID ANTIOXIDANT ACTIVITY; ENZYME-ACTIVITIES; CELL-DEATH; APOPTOSIS; RATS;
   OLD
AB This study observed the effect of salidroside on improving oxidative aging induced by D-galactose in mice by enhancing aerobic swimming. In this study, the oxidative aging model of mice was induced by D-galactose, and the changes of organ index, histopathological changes, and mRNA expression in serum and tissue of oxidative aging mice after aerobic swimming and aerobic swimming + salidroside were detected. The results showed that aerobic swimming and aerobic swimming + salidroside inhibited the decline of the heart index, liver index, spleen index, and kidney index caused by oxidative aging in mice. Aerobic swimming and aerobic swimming + salidroside increased the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione (GSH) in the serum, liver and spleen of oxidative aging mice, and decreased the level of malondialdehyde (MDA). The study also found that aerobic swimming and aerobic swimming + salidroside can reduce the damage of oxidative aging to liver and spleen tissues. Quantitative polymerase chain reaction (qPCR) showed that aerobic swimming and aerobic swimming + salidroside could up-regulate the mRNA expression of CAT, GSH, Cu/Zn-SOD, Mn-SOD and GSH-PX in murine liver tissue. The results showed that aerobic swimming could effectively inhibit D-galactose-induced oxidative aging of mice, and the effect of aerobic swimming + salidroside was better than that of aerobic swimming alone. It can be seen that salidroside can enhance the improvement of aerobic swimming on oxidative aging and can be used as a sports supplement.
C1 [Zhang, Jing] Chongqing Chem Ind Vocat Coll, Environm & Qual Inspect Coll, Chongqing 401228, Peoples R China.
   [Dai, Xiankun] Second Peoples Hosp Banan Dist, Pharm Dept, Chongqing 400054, Peoples R China.
   [Wang, Mengwei; Song, Jing; Long, Xingyao; Qian, Yu; Zhao, Xin] Chongqing Univ Educ, Collaborat Innovat Ctr Child Nutr & Hlth Dev, Chongqing 400067, Peoples R China.
C3 Chongqing University of Education
RP Qian, Y; Zhao, X (corresponding author), Chongqing Univ Educ, Collaborat Innovat Ctr Child Nutr & Hlth Dev, Chongqing 400067, Peoples R China.
EM qianyu@cque.edu.cn; zhaoxin@cque.edu.cn
RI Long, Xingyao/PDX-0825-2025
OI LONG, XINGYAO/0000-0003-3663-4243
FU Science and Technology Research Program of Chongqing Municipal Education
   Commission [KJQN202104504, KJZD-K202001601]
FX This research was supported by the Science and Technology Research
   Program of Chongqing Municipal Education Commission (KJQN202104504,
   KJZD-K202001601).
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NR 32
TC 0
Z9 0
U1 1
U2 12
PU POLSKIE TOWARZYSTWO FARMACEUTYCZNE
PI WARSAW
PA DLUGA 16, 00-238 WARSAW, POLAND
SN 0001-6837
EI 2353-5288
J9 ACTA POL PHARM
JI ACTA POL. PHARM.
PD SEP-OCT
PY 2023
VL 80
IS 5
BP 831
EP 840
DI 10.32383/appdr/172999
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GN0B5
UT WOS:001153219400013
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lu, RF
   Wu, YG
   Guo, HG
   Zhang, ZY
   He, YZ
AF Lu, Rufeng
   Wu, Yueguo
   Guo, Honggang
   Zhang, Zhuoyi
   He, Yuzhou
TI Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury
   in Mice
SO DOSE-RESPONSE
LA English
DT Article
DE salidroside; influenza A virus; acute lung injury; inflammatory
   cytokines; Toll-like receptor 4
AB Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, the effects of salidroside on influenza A virus-induced ALI were investigated in a murine model. BALB/c mice were intranasally inoculated with H1N1 virus and treated with salidroside. The results of this study show that salidroside treatment (30 and 60 mg/kg) significantly attenuated the H1N1 virus-induced histological alterations in the lung and inhibited inflammatory cytokine production. Salidroside also decreased the wet/dry ratio, viral titers, and Toll-like receptor 4 expression in the lungs. Therefore, salidroside may represent a potential therapeutic reagent for the treatment of influenza A virus-induced ALI.
C1 [Lu, Rufeng; Zhang, Zhuoyi; He, Yuzhou] Zhejiang Chinese Med Univ, Dept Emergency, Affiliated Hosp 1, Youdian Rd 54, Hangzhou 310006, Zhejiang, Peoples R China.
   [Wu, Yueguo] Hangzhou Med Coll, Inst Mat Med, Hangzhou, Peoples R China.
   [Guo, Honggang] Hangzhou Med Coll, Key Lab Expt Anim & Safety Evaluat, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Hangzhou Medical College; Hangzhou
   Medical College
RP Zhang, ZY; He, YZ (corresponding author), Zhejiang Chinese Med Univ, Dept Emergency, Affiliated Hosp 1, Youdian Rd 54, Hangzhou 310006, Zhejiang, Peoples R China.
EM zhangzhuoyi123@hotmail.com; hyzxy1995@126.com
FU Scientific Research Fund of Zhejiang Province Chinese Medicine
   [2019ZA045]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by the Scientific Research Fund of Zhejiang Province
   Chinese Medicine (2019ZA045).
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NR 19
TC 3
Z9 4
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-3258
J9 DOSE-RESPONSE
JI Dose-Response
PD APR
PY 2021
VL 19
IS 2
AR 15593258211011335
DI 10.1177/15593258211011335
PG 5
WC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
GA XI4TN
UT WOS:000726106100001
PM 34017230
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, Y
   Wei, X
   Liu, SL
   Zhao, Y
   Jin, S
   Yang, XY
AF Li, Ye
   Wei, Xin
   Liu, Shu-Li
   Zhao, Ying
   Jin, Si
   Yang, Xiao-Yan
TI Salidroside protects cardiac function in mice with diabetic
   cardiomyopathy via activation of mitochondrial biogenesis and SIRT3
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE diabetic cardiomyopathy; mitochondrial biogenesis; salidroside; SIRT3
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DEACETYLATION; HEART; DYSFUNCTION
AB To investigate the effects and the underlying mechanisms of salidroside on diabetic cardiomyopathy, diabetes was induced in mice by a long-term high-fat diet and a low-dose injection of streptozocin. Measurements of cardiac function, biochemical analysis, and histopathological examinations were conducted to evaluate the therapeutic effects of salidroside. In this study, we found that diabetic mice exhibited decreased cardiac systolic function and impaired mitochondrial ultrastructure. Pre-treatment with salidroside protected mice against myocardial dysfunction, reduced blood glucose, improved insulin resistance, and induced mitochondrial biogenesis. Neonatal rat cardiomyocytes were cultured to explore the mechanisms of salidroside in vitro. Salidroside alleviated decreased expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1 alpha), mitochondrial transcription factor A (TFAM) via phosphorylation of 5 ' AMP-activated protein kinase (AMPK), which may be associated with mitochondrial biogenesis. Salidroside also increased sirtuin-3 (SIRT3) expression in cardiomyocytes. Furthermore, salidroside promoted the translocation of SIRT3 from cytoplasm to mitochondria and increased the deacetylation of mitochondrial proteins such as manganese-dependent superoxide dismutase (MnSOD). In Conclusion, salidroside not only improved diabetes, but also ameliorated diabetic cardiomyopathy, which was at least partly associated with the activation of mitochondrial SIRT3, AMPK/Akt, and PGC-1 alpha/TFAM and subsequent improving mitochondrial function.
C1 [Li, Ye; Liu, Shu-Li; Yang, Xiao-Yan] Huazhong Univ Sci & Technol, Sch Basic Med, Hubei Key Lab Drug Target Res & Pharmacodynam Eva, Tongji Med Coll,Dept Pharmacol, Wuhan, Peoples R China.
   [Wei, Xin] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastrointestinal Surg, Tongji Med Coll, Wuhan, Peoples R China.
   [Zhao, Ying; Jin, Si] Huazhong Univ Sci & Technol, Inst Geriatr Med, Liyuan Hosp, Tongji Med Coll,Dept Endocrinol, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Inst Geriatr Med, Liyuan Hosp, Dept Endocrinol, Wuhan 430074, Hubei, Peoples R China.; Yang, XY (corresponding author), Huazhong Univ Sci & Technol, Dept Pharmacol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
EM jinsi@mail.hust.edu.cn; tjyangxy@mail.hust.edu.cn
RI ; jin, si/KGK-5977-2024
OI Yang, Xiaoyan/0000-0002-4836-8248; jin, si/0000-0003-0727-6715
FU Fundamental Research Funds for the Central Universities
   [2018KFYYXJJ082]; National Natural Science Foundation of China
   [81000080, 81470458]
FX Fundamental Research Funds for the Central Universities, Grant/Award
   Number: 2018KFYYXJJ082; National Natural Science Foundation of China,
   Grant/Award Numbers: 81000080, 81470458
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NR 31
TC 42
Z9 49
U1 1
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD AUG
PY 2021
VL 35
IS 8
BP 4579
EP 4591
DI 10.1002/ptr.7175
EA MAY 2021
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UA0GE
UT WOS:000656111600001
PM 34056772
DA 2026-05-27
ER

PT J
AU Zhu, FC
   Yan, ZX
   Dai, JL
   Wang, JW
   Huang, SP
   Ma, JB
   Chen, ND
   Zang, YJ
AF Zhu, Fucheng
   Yan, Zixu
   Dai, Jingli
   Wang, Juwen
   Huang, Shiping
   Ma, Jingbo
   Chen, Naidong
   Zang, Yongjun
TI Efficient synthesis of salidroside using mined glycosyltransferase
   through cascade reaction
SO BIOPROCESS AND BIOSYSTEMS ENGINEERING
LA English
DT Article
DE Glycosyltransferase; Regioselectivity; Salidroside; Fed-batch cascade
   reaction
ID GLUCOSYLTRANSFERASE; SUBSTRATE
AB Salidroside has been widely utilized in the food and cosmetics industries. However, the efficient synthesis of salidroside remains a challenge. In this study, a potential uridine diphosphate-dependent glycosyltransferase (UGT) from Bacillus subtilis 168 (named UGT(BS)) was identified through evolutionary relationship analysis and molecular docking, with findings subsequently validated by experimental verification. The optimal conversion of UGT(BS) for salidroside synthesis reached 98.4% (mol/mol). Additionally, a conversion exceeding 85% (mol/mol) was achieved using the UGT(BS)-AtSuSy cascade reaction with tyrosol concentrations ranging from 1 to 10 mM, demonstrating the substrate tolerance of UGT(BS) at high concentrations. Kinetic determination and molecular docking confirmed that the strengthened hydrogen bonds and suitable active center conformation between the enzyme and substrate may account for the efficient synthesis of salidroside. Furthermore, 43.5 mM of salidroside was obtained using a fed-batch cascade reaction strategy. The UGT(BS) identified in this study shows significant potential for salidroside synthesis, and the strategy employed here serves as a reference for the discovery of related enzymes.
C1 [Zhu, Fucheng; Wang, Juwen; Huang, Shiping; Ma, Jingbo; Chen, Naidong; Zang, Yongjun] West Anhui Univ, Coll Biol & Pharmaceut Engn, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Anhui Prov Key Lab Qual Evaluat & Improvement Trad, Luan City 237012, Peoples R China.
   [Yan, Zixu; Dai, Jingli] Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China.
C3 West Anhui University; Anhui University of Chinese Medicine
RP Zhu, FC; Zang, YJ (corresponding author), West Anhui Univ, Coll Biol & Pharmaceut Engn, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Anhui Prov Key Lab Qual Evaluat & Improvement Trad, Luan City 237012, Peoples R China.
EM fucheng323@163.com; zangyongjun@yeah.net
FU National Natural Science Foundation of China; Anhui University
   scientific research project outstanding youth project [2023AH030109];
   Anhui Province Excellent Young Teacher Training Project [YQZD2023071];
   Scientific Research Project of Anhui province [2022AH051682]; Anhui
   Scientific Research and Innovation Team of Quality Evaluation and
   Improvement of Traditional Chinese Medicine [2022AH010090];  [32201979]
FX This research was supported by the National Natural Science Foundation
   of China (32201979), Anhui University scientific research project
   outstanding youth project (2023AH030109). Anhui Province Excellent Young
   Teacher Training Project (YQZD2023071). Scientific Research Project of
   Anhui province (2022AH051682), Anhui Scientific Research and Innovation
   Team of Quality Evaluation and Improvement of Traditional Chinese
   Medicine (2022AH010090).
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NR 37
TC 1
Z9 1
U1 8
U2 30
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1615-7591
EI 1615-7605
J9 BIOPROC BIOSYST ENG
JI Bioprocess. Biosyst. Eng.
PD JUN
PY 2025
VL 48
IS 6
BP 939
EP 949
DI 10.1007/s00449-025-03153-1
EA MAR 2025
PG 11
WC Biotechnology & Applied Microbiology; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 2TP9L
UT WOS:001454875600001
PM 40146300
DA 2026-05-27
ER

PT J
AU Li, GS
   Xu, QL
   Hu, N
   Liu, XY
   Jiang, YQ
   Xue, HL
   Zang, YJ
   Zhu, FC
AF Li, Guosi
   Xu, Qilin
   Hu, Nan
   Liu, Xinyang
   Jiang, Yiqi
   Xue, Hailong
   Zang, Yongjun
   Zhu, Fucheng
TI Highly efficient biosynthesis of salidroside by a
   UDP-glucosyltransferase-catalyzed cascade reaction
SO BIOTECHNOLOGY LETTERS
LA English
DT Article
DE Salidroside; Tyrosol; UDP-glucosyltransferase; Sucrose synthase;
   UDP-glucose regeneration
AB ObjectiveSalidroside is an important plant-derived aromatic compound with diverse biological properties. The main objective of this study was to synthesize salidroside from tyrosol using UDP-glucosyltransferase (UGT) with in situ regeneration of UDP-glucose (UDPG).ResultsThe UDP-glucosyltransferase 85A1 (UGT85A1) from Arabidopsis thaliana, which showed high activity and regioselectivity towards tyrosol, was selected for the production of salidroside. Then, an in vitro cascade reaction for in situ regeneration of UDPG was constructed by coupling UGT85A1 to sucrose synthase from Glycine max (GmSuSy). The optimal UGT85A1-GmSuSy activity ratio of 1:2 was determined to balance the efficiency of salidroside production and UDP-glucose regeneration. Different cascade reaction conditions for salidroside production were also determined. Under the optimized condition, salidroside was produced at a titer of 6.0 g/L with a corresponding molar conversion of 99.6% and a specific productivity of 199.1 mg/L/h in a continuous feeding reactor.ConclusionThis is the highest salidroside titer ever reported so far using biocatalytic approach.
C1 [Li, Guosi; Xu, Qilin; Hu, Nan; Zang, Yongjun; Zhu, Fucheng] West Anhui Univ, Gener Technol Res Ctr Anhui Tradit Chinese Med Ind, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Luan 237012, Anhui, Peoples R China.
   [Li, Guosi; Xu, Qilin; Liu, Xinyang; Zang, Yongjun; Zhu, Fucheng] West Anhui Univ, Anhui Engn Res Ctr Ecoagr Tradit Chinese Med, Dept Biol & Pharmaceut Engn, Luan 237012, Anhui, Peoples R China.
   [Jiang, Yiqi; Xue, Hailong] Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Zhejiang, Peoples R China.
C3 West Anhui University; West Anhui University; Zhejiang University
RP Li, GS; Zhu, FC (corresponding author), West Anhui Univ, Gener Technol Res Ctr Anhui Tradit Chinese Med Ind, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Luan 237012, Anhui, Peoples R China.; Li, GS; Zhu, FC (corresponding author), West Anhui Univ, Anhui Engn Res Ctr Ecoagr Tradit Chinese Med, Dept Biol & Pharmaceut Engn, Luan 237012, Anhui, Peoples R China.
EM liguosi1989@163.com; fucheng323@163.com
RI Xu, Qilin/JDD-9383-2023
FU Open Fund of Anhui Engineering Laboratory for Conservation and
   Sustainable Utilization of Traditional Chinese Medicine Resources;
   Natural Science Foundation of Higher Education Institutions of Anhui
   Province [2023AH052649]; Fund of Generic Technology Research center for
   Anhui Traditional Chinese Medicine Industry [AHTCMGTRC-2023-09];
   National Natural Science Foundation of China [32201979]; University
   Research Project of Anhui Province [2022AH051682];  [TCMRPSU-2022-03]
FX This work was funded by the Open Fund of Anhui Engineering Laboratory
   for Conservation and Sustainable Utilization of Traditional Chinese
   Medicine Resources (TCMRPSU-2022-03), the Natural Science Foundation of
   Higher Education Institutions of Anhui Province (2023AH052649), the Fund
   of Generic Technology Research center for Anhui Traditional Chinese
   Medicine Industry (AHTCMGTRC-2023-09), the National Natural Science
   Foundation of China (32201979) and the University Research Project of
   Anhui Province (2022AH051682).
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TC 17
Z9 19
U1 12
U2 109
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-5492
EI 1573-6776
J9 BIOTECHNOL LETT
JI Biotechnol. Lett.
PD APR
PY 2024
VL 46
IS 2
BP 147
EP 159
DI 10.1007/s10529-023-03453-0
EA JAN 2024
PG 13
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA IZ5C9
UT WOS:001137677000001
PM 38184486
DA 2026-05-27
ER

PT J
AU Chen, ZL
   Ning, FJ
   He, XC
   Peng, HL
   Xiong, H
AF Chen, Zhenlin
   Ning, Fangjian
   He, Xingcun
   Peng, Hailong
   Xiong, Hua
TI Controlled Release of Salidroside Microspheres Prepared Using a Chitosan
   and Methylcellulose Interpenetrating Polymer Network
SO INTERNATIONAL JOURNAL OF FOOD ENGINEERING
LA English
DT Article
DE Chitosan; methylcellulose; microspheres; salidroside; interpenetrating
   polymer network
ID MESOPOROUS SILICA NANOPARTICLES; RHODIOLA-ROSEA; LIPOSOMES
AB In this work, salidroside, a functional food agent, was incorporated into novel interpenetrating polymer network microspheres (IPN-Ms) prepared by chitosan (CS) and methylcellulose (MC) for controlled release and stabilization. IPN-Ms were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry and X-ray diffraction. The result indicated that salidroside-loaded IPN-Ms (S-IPN-Ms) are hollow and highly spherical, with a coarse pleated surface and a particle size ranging from 5 to 30 mu m. Schiff base formation and the hemiacetal reaction are the primary mechanisms underlying the interpenetrating network cross-linking of IPN-Ms. In S-IPN-Ms, the CS and MC were homogeneously blended, and the salidroside was molecularly and amorphously dispersed. The encapsulation efficiency of the salidroside within the S-IPN-Ms was up to 75.64 %. In the S-IPN-M complex, the release of salidroside by S-IPN-Ms was governed by burst and sustained release, and Fickian diffusion was the primary release mechanism for the entire release process. Thus, controlled release and stabilization of salidroside were achieved through incorporation of salidroside into IPN-Ms prepared by chitosan (CS) and methylcellulose.
C1 [Chen, Zhenlin; He, Xingcun] Hezhou Univ, Res Inst Food Sci & Engn Technol, Hezhou 542899, Guangxi, Peoples R China.
   [Chen, Zhenlin; Ning, Fangjian; Peng, Hailong; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
   [Peng, Hailong] Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Jiangxi, Peoples R China.
C3 Hezhou University; Nanchang University; Nanchang University
RP Xiong, H (corresponding author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
EM huaxiong100@126.com
RI Ning, Fangjian/AHA-4287-2022
OI Ning, Fangjian/0000-0001-6193-1704
FU Planning Subject of "the Twelfth Five-Year-Plan" of the National Science
   and Technology for the Rural Development of China [2013AA102203-05];
   National Natural Science Foundation of China [21667018]; Graduate
   Student Innovation Fund of Jiangxi Province [YC2016-B013]
FX This work was supported by the Planning Subject of "the Twelfth
   Five-Year-Plan" of the National Science and Technology for the Rural
   Development of China (2013AA102203-05), the National Natural Science
   Foundation of China (21667018), and Graduate Student Innovation Fund of
   Jiangxi Province (YC2016-B013).
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NR 33
TC 5
Z9 5
U1 0
U2 63
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2194-5764
EI 1556-3758
J9 INT J FOOD ENG
JI Int. J. Food Eng.
PD OCT
PY 2017
VL 13
IS 10
AR 20170236
DI 10.1515/ijfe-2017-0236
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FL0LR
UT WOS:000413903400003
DA 2026-05-27
ER

PT J
AU Yan, ZQ
   Chen, J
   Xing, GX
   Huang, JG
   Hou, XH
   Zhang, Y
AF Yan, Zhi-Qiang
   Chen, Jun
   Xing, Guo-Xiang
   Huang, Jian-Guo
   Hou, Xiang-Hong
   Zhang, Yong
TI Salidroside prevents cognitive impairment induced by chronic cerebral
   hypoperfusion in rats
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Salidroside; chronic cerebral hypoperfusion; cognition; apoptosis
ID LONG-TERM POTENTIATION; MEMORY; DEFICITS; STREPTOZOTOCIN; ISCHEMIA;
   NEURONS; DAMAGE; DEATH; MOTOR; LIFE
AB Objective To investigate the effects of salidroside on cognitive dysfunction induced by chronic cerebral hypoperfusion in rats.
   Methods Male Sprague-Dawley rats (n=36) were divided into three groups (n=12 per group): sham operation; bilateral permanent occlusion of the common carotid arteries (2-VO); 2-VO+salidroside. Rats received 20mg/kg per day salidroside or vehicle intraperitoneal injection beginning the day before surgery and continuing until 34 days postoperatively. Cognitive function was evaluated by Morris water maze test and hippocampal long-term potentiation (LTP) measurement. Hippocampal neuronal apoptosis was evaluated via immunofluorescence.
   Results Chronic cerebral hypoperfusion caused marked cognitive deficit and LTP inhibition. These effects were largely ameliorated by salidroside administration. Salidroside prevented caspase-3 activation, increased the ratio of Bax/Bcl-2, and reversed hippocampal neuronal loss induced by chronic cerebral hypoperfusion.
   Conclusions Salidroside prevents cognitive deficits caused by chronic cerebral hypoperfusion in rats, and alleviates apoptosis in the hippocampal CA1 area.
C1 [Yan, Zhi-Qiang] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China.
   [Yan, Zhi-Qiang; Xing, Guo-Xiang; Huang, Jian-Guo] Lanzhou Mil Command, Dept Neurosurg, Urumqi Gen Hosp, Urumqi, Peoples R China.
   [Chen, Jun] Tradit Chinese Med Hosp Shan Xi Prov, Dept Encephalopathy, Xian, Peoples R China.
   [Hou, Xiang-Hong] Fourth Mil Med Univ, Dept Food Hyg & Nutr, Xian 710032, Peoples R China.
   [Zhang, Yong] Fourth Mil Med Univ, Dept Anat Histol & Embryol, KK Leung Brain Res Ctr, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Zhang, Y (corresponding author), Fourth Mil Med Univ, Dept Anat Histol & Embryol, 169 Changle Rd, Xian 710032, Peoples R China.
EM zhangyongdoctor@163.com
FU Natural Science Foundation of China [81201000, 81100816]
FX This work was supported by a research grant from the Natural Science
   Foundation of China (81201000, 81100816).
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NR 30
TC 24
Z9 29
U1 1
U2 24
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD JUN
PY 2015
VL 43
IS 3
BP 402
EP 411
DI 10.1177/0300060514566648
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CI5DH
UT WOS:000354772600015
PM 25858674
OA gold
DA 2026-05-27
ER

PT J
AU Chung, D
   Kim, SY
   Ahn, JH
AF Chung, Daeun
   Kim, So Yeon
   Ahn, Joong-Hoon
TI Production of three phenylethanoids, tyrosol, hydroxytyrosol, and
   salidroside, using plant genes expressing in Escherichia coli
SO SCIENTIFIC REPORTS
LA English
DT Article
ID RHODIOLA-ROSEA EXTRACT; CAFFEIC ACID; ARABIDOPSIS GLYCOSYLTRANSFERASES;
   BIOCHEMICAL EVALUATION; OLIVE OIL; GLUCOSYLTRANSFERASE; BIOSYNTHESIS;
   OVEREXPRESSION; SYNTHASE; PATHWAY
AB Polyphenols, which include phenolic acids, flavonoids, stilbenes, and phenylethanoids, are generally known as useful antioxidants. Tyrosol, hydroxytyrosol, and salidroside are typical phenylethanoids. Phenylethanoids are found in plants such as olive, green tea, and Rhodiola and have various biological activities, including the prevention of cardiovascular diseases, cancer, and brain damage. We used Escherichia coli to synthesize three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside. To synthesize tyrosol, the aromatic aldehyde synthase (AAS) was expressed in E. coli. Hydroxytyrosol was synthesized using E. coli harboring AAS and HpaBC, which encodes hydroxylase. In order to synthesize salidroside, 12 uridine diphosphate-dependent glycosyltransferases (UGTs) were screened and UGT85A1 was found to convert tyrosol to salidroside. Using E. coli harboring AAS and UGT85A1, salidroside was synthesized. Through the optimization of these three E. coli strains, we were able to synthesize 531 mg/L tyrosol, 208 mg/L hydroxytyrosol, and 288 mg/L salidroside, respectively.
C1 [Chung, Daeun; Kim, So Yeon; Ahn, Joong-Hoon] Konkuk Univ, Dept Integrat Biosci & Biotechnol, Bio Mol Informat Ctr, Seoul 05029, South Korea.
C3 Konkuk University
RP Ahn, JH (corresponding author), Konkuk Univ, Dept Integrat Biosci & Biotechnol, Bio Mol Informat Ctr, Seoul 05029, South Korea.
EM jhahn@konkuk.ac.kr
RI Chung, Dillon/AAB-3934-2019; /AAN-8747-2020
OI Chung, Dillon/0000-0002-0329-3828; Chung, Dillon/0000-0002-0329-3828;
   Morrison, Phillip/0000-0001-9470-4540
FU Priority Research Centers Program through the National Research
   Foundation (NRF) - Ministry of Education, Science and Technology,
   Republic of Korea [2009-0093824];  [NRF-2016R1A2B4014057]; National
   Research Foundation of Korea [2009-0093824] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX This work was supported by a grant (NRF-2016R1A2B4014057), and Priority
   Research Centers Program (2009-0093824) through the National Research
   Foundation (NRF) funded by the Ministry of Education, Science and
   Technology, Republic of Korea.
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NR 36
TC 139
Z9 159
U1 8
U2 160
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 31
PY 2017
VL 7
AR 2578
DI 10.1038/s41598-017-02042-2
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EW5BE
UT WOS:000402519400042
PM 29176558
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, XF
   Ye, XL
   Li, XB
   Sun, X
   Liang, QA
   Tao, LZ
   Kang, XG
   Chen, JZ
AF Li, Xiaofeng
   Ye, Xiaoli
   Li, Xiaobing
   Sun, Xin
   Liang, Qiang
   Tao, Lizhen
   Kang, Xiaogang
   Chen, Jianzong
TI Salidroside protects against MPP+-induced apoptosis in PC12
   cells by inhibiting the NO pathway
SO BRAIN RESEARCH
LA English
DT Article
DE Parkinson's disease; Salidroside; PC12 cells; Nitric oxide; MPP+;
   Apoptosis
ID GREEN TEA POLYPHENOLS; NITRIC-OXIDE; PARKINSONS-DISEASE; PHENYLPROPANOID
   GLYCOSIDES; INDUCED NEUROTOXICITY; GROWTH; MPTP; INVOLVEMENT; GLUTAMATE;
   DAMAGE
AB Oxidative stress plays an important role in Parkinson's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., has potent antioxidant properties. In the present study, we investigated the protective activity of salidroside against 1-methy1-4-phenylpyridinium (MPP+)-induced apoptosis in PC12 cells. We found that incubation of PC12 cells with salidroside prior to MPP+ exposure significantly reduced cell apoptosis and attenuated collapse of the mitochondrial membrane potential (MMP). Furthermore, salidroside inhibited the MPP+-induced nitric oxide (NO) increase and overexpression of nNOS and iNOS and suppressed accumulation of reactive oxygen species (ROS) and intracellular free Ca2+. Our results show that the protective effects of salidroside on PC12 cells are mediated, at least in part, by inhibition of the NO pathway. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Li, Xiaofeng; Li, Xiaobing; Sun, Xin; Liang, Qiang; Tao, Lizhen; Kang, Xiaogang; Chen, Jianzong] Fourth Mil Med Univ, Res Ctr Tradit Chinese Med, Xijing Hosp, Lab Senile Encephalopathy Integrated Tradit Chine, Xian 710032, Peoples R China.
   [Ye, Xiaoli] Fourth Mil Med Univ, Dept Endocrinol, Xijing Hosp, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Res Ctr Tradit Chinese Med, Xijing Hosp, Lab Senile Encephalopathy Integrated Tradit Chine, 17 Changlexi Rd, Xian 710032, Peoples R China.
EM lixiaofeng19982003@126.com; jzchen57@fmmu.edu.cn
RI Sun, Shinford/AAI-4648-2020
OI Li, Xiaobing/0000-0001-5961-2114
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NR 42
TC 56
Z9 69
U1 0
U2 43
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD MAR 25
PY 2011
VL 1382
BP 9
EP 18
DI 10.1016/j.brainres.2011.01.015
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 745AF
UT WOS:000289135600002
PM 21241673
DA 2026-05-27
ER

PT J
AU Qian, J
   Wang, XH
   Wei, BZ
   Zhou, GX
   Zhu, SX
   Liu, C
AF Qian Jing
   Wang Xiaohong
   Wei Benzhong
   Zhou Guoxiong
   Zhu Shunxing
   Liu Chun
TI Therapeutic effects of salidroside vs pyrrolidine dithiocarbamate
   against severe acute pancreatitis in rats
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE rhodioloside; pyrrolidines; ethylenebis (dithio-carbamates);
   pancreatitis; autophagy; NF-kappa B; signal transduction
ID INDUCED BRAIN-INJURY; FACTOR-KAPPA-B; AUTOPHAGY; INFLAMMATION;
   PATHOGENESIS; HOMEOSTASIS; INHIBITION; APOPTOSIS; PATHWAY; MICE
AB OBJECTIVE: To evaluate the therapeutic effectiveness of salidroside (Sal) and pyrrolidine dithiocarbamate (PDTC) against severe acute pancreatitis (SAP) in a rat model. METHODS: Rat models of SAP were established by retrograde infusion of sodium taurocholate solution. SAP rats were randomly divided into 6 groups: SAP 3 h group, SAP 24 h group, low-dose Sal treatment group (Sal L+S), middle-dose Sal treatment group (Sal M+S), high-dose Sal treatment group (Sal H+S) and PDTC treatment group (PDTC+S). The serum amylase, tumor necrosis factor-alpha (TNF-alpha), interleukin-113 (IL-113) and interleukin-10 (IL-10) levels were determined by optical turbidimetry and enzyme-linked immunosorbent assay. The expression of Beclin-1, microtubule-associated protein light chain 3II (LC3 II ), lysosome associated membrane protein 2 (LAMP2), interleukin-1 receptor associated kinase 1 (IRAK1), inhibitor alpha of nuclear transcription factor-Kappa B (I Kappa B alpha), nuclear transcription factor-Kappa B 65 (p65) in the pancreas tissues were detected by quantitative real-time polymerase chain reaction and Western blot, while the p-I Kappa B alpha and p-p65 levels were detected by Western blot. Pathological changes of the pancreas and all the other indexes were observed at 3 and 24 h after operation. RESULTS: The serum IL-10 level, I Kappa B alpha and LAMP2 levels in Sal M+S, Sal H+S and PDTC+S groups were higher than those in SAP 24 h group, while all the other indexes in these three groups were all lower significantly than those in SAP 24 h group. There was no significant difference in all indexes between Sal H+S and PDTC+S groups. CONCLUSION: High-dose Sal has an effectively therapeutic effect on SAP in rats, which was similar to PDTC.
C1 [Qian Jing] Yizheng Hosp, Dept Gen Surg, Nanjing Drum Tower Hosp Grp, Yizheng 211900, Peoples R China.
   [Wang Xiaohong] Yizheng Hosp, Dept Gastroenterol, Nanjing Drum Tower Hosp Grp, Yizheng 211900, Peoples R China.
   [Wei Benzhong] Yizheng Hosp, Dept Anesthesiol, Nanjing Drum Tower Hosp Grp, Yizheng 211900, Peoples R China.
   [Zhou Guoxiong] Nantong Univ, Affiliated Hosp, Dept Gastroenterol, Nantong 226001, Peoples R China.
   [Zhu Shunxing; Liu Chun] Nantong Univ, Dept Lab Anim Ctr, Nantong 226001, Peoples R China.
C3 Nantong University; Nantong University
RP Wang, XH (corresponding author), Yizheng Hosp, Dept Gastroenterol, Nanjing Drum Tower Hosp Grp, Yizheng 211900, Peoples R China.
EM wx102474wx@163.com
RI Wang, Xiaohong/JXL-8370-2024
FU Traditional Chinese Medicine Technology Development Plan Project of
   Jiangsu Province [YB2020088]; Health Innovation Project of Lvyang
   Jinfeng Plan of Yangzhou City [LJ202037]
FX Supported by the Traditional Chinese Medicine Technology Development
   Plan Project of Jiangsu Province in 2020: Basic and Clinical Study on
   Salidroside in the Adjuvant Treatment of Severe Acute Pancreatitis (No.
   YB2020088) and the Health Innovation Project of Lvyang Jinfeng Plan of
   Yangzhou City in 2020: Basic and Clinical Study on Salidroside in the
   Adjuvant Treatment of Severe Acute Pancreatitis (No. LJ202037)
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NR 41
TC 8
Z9 8
U1 0
U2 9
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD FEB
PY 2022
VL 42
IS 1
BP 49
EP 57
DI 10.19852/j.cnki.jtcm.20210707.002
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA YY3VQ
UT WOS:000754719100001
PM 35322632
DA 2026-05-27
ER

PT J
AU Hu, BJ
   Zou, Y
   Liu, SS
   Wang, J
   Zhu, JL
   Li, JB
   Bo, LL
   Deng, XM
AF Hu, Baoji
   Zou, Yun
   Liu, Shanshan
   Wang, Jun
   Zhu, Jiali
   Li, Jinbao
   Bo, Lulong
   Deng, Xiaoming
TI Salidroside Attenuates Concanavalin A-Induced Hepatitis via Modulating
   Cytokines Secretion and Lymphocyte Migration in Mice
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID RHODIOLA-ROSEA; LIVER-INJURY; KAPPA-B; EXPRESSION; ACTIVATION;
   RESPONSES; PATHWAYS
AB Salidroside, isolated from the medicinal plant Rhodiola, was reported to serve as an "adaptogen." This study was designed to explore the protective effect of salidroside on concanavalin A- (Con A-) induced hepatitis in mice and investigate potential mechanisms. C57BL/6 mice were randomly divided into control group, Con A group, and salidroside group. Salidroside (50mg/kg) was injected intravenously followed by Con A administration. The levels of ALT, AST, inflammatory cytokines and CXCL-10 were examined. The pathological damage of livers was assessed, the amounts of phosphorylated IkB alpha and p65 were measured, and the numbers of CD4(+) and CD8(+) T lymphocytes in the blood, spleen and infiltrated in the liver were calculated. Our results showed that salidroside pretreatment reduced the levels of ALT, AST dramatically and suppressed the secretion of proinflammatory cytokines through downregulating the activity of NF-kB partly. Salidroside altered the distribution of CD4(+) and CD8(+) T lymphocyte in the liver and spleen through regulating CXCL-10 and decreased the severity of liver injuries. In conclusion, these results confirm the efficacy of salidroside in the prevention of immune mediated hepatitis in mice.
C1 [Hu, Baoji; Zou, Yun; Liu, Shanshan; Wang, Jun; Zhu, Jiali; Li, Jinbao; Bo, Lulong; Deng, Xiaoming] Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China.
   [Hu, Baoji] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Anesthesiol, Shanghai 201399, Peoples R China.
   [Liu, Shanshan] Xiamen Univ, Chenggong Hosp, Dept Anesthesiol, Xiamen 361003, Peoples R China.
C3 Naval Medical University; Fudan University; Xiamen University
RP Bo, LL (corresponding author), Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM nbastars@126.com; deng_x@yahoo.com
RI Hu, Baoji/Z-4796-2019; Deng, Xiaoming/E-2876-2010; Bo,
   Lulong/MVT-7945-2025; Zhu, Jiali/PAU-6772-2025
OI Hu, Baoji/0000-0001-6768-7984; Bo, Lulong/0000-0001-6787-1837; 
FU National Natural Science Foundation of China [81201492, 81272065]
FX This work was supported by researches Grants from National Natural
   Science Foundation of China (no. 81201492 to Lulong Bo and no. 81272065
   to Xiaoming Deng).
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NR 35
TC 26
Z9 31
U1 0
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2014
VL 2014
AR 314081
DI 10.1155/2014/314081
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA AF5ND
UT WOS:000334759300001
PM 24808635
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chai, YH
   Chen, F
   Li, HX
   Sun, XH
   Yang, PP
   Xi, YM
AF Chai, Yihong
   Chen, Feng
   Li, Hongxing
   Sun, Xiaohong
   Yang, Panpan
   Xi, YaMing
TI Mechanism of salidroside regulating autophagy based on network
   pharmacology and molecular docking
SO ANTI-CANCER DRUGS
LA English
DT Article
DE antitumor; autophagy; network pharmacology; salidroside
ID CANCER; PATHWAYS
AB Salidroside is a natural product of phenols with a wide range of pharmacological functions, but whether it plays a role in regulating autophagy is unclear. We systematically investigated the regulatory effect and molecular mechanism of salidroside on autophagy through network pharmacology, which provided a theoretical basis for subsequent experimental research. First, the target genes of salidroside were obtained using the Chinese Medicine System Pharmacology Database and Analysis Platform, and the target genes were converted into standardized gene names using the Uniprot website. At the same time, autophagy-related genes were collected from GeneCards, and preliminary handling of data to obtain intersecting genes. Then, the String website was used to construct a protein-protein interaction network, and to perform the Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway analysis. To observe the specific molecular mechanism by which salidroside regulates autophagy, we constructed a drug component-target genes-autophagy network. Finally, we performed molecular docking to verify the possible binding conformation between salidroside and the candidate target. By searching the database and analyzing the data, we found that 113 target genes in salidroside interact with autophagy. Salidroside regulate autophagy in relation to a number of important oncogenes and signaling pathways. Molecular docking confirmed that salidroside has high affinity with mTOR, SIRT1, and AKT1. Through network pharmacology combined with molecular docking-validated research methods, we revealed the underlying mechanism of salidroside regulation of autophagy. This study not only provides new systematic insights into the underlying mechanism of salidroside in autophagy, but also provides new ideas for network approaches for autophagy-related research.
C1 [Chai, Yihong; Chen, Feng; Li, Hongxing; Sun, Xiaohong; Yang, Panpan; Xi, YaMing] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China.
   [Li, Hongxing; Yang, Panpan] Lanzhou Univ, Dept Obstet & Gynaecol, Hosp 1, Lanzhou, Peoples R China.
   [Xi, YaMing] Lanzhou Univ, Dept Hematol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University; Lanzhou University
RP Xi, YM (corresponding author), Lanzhou Univ, Dept Hematol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
EM xiyaming02@163.com
RI chen, feng/PDX-5000-2025; Yang, Panpan/GRF-1577-2022
FU Gansu Province Science and Technology Foundation for Youths
   [20JR10RA705]; Innovation Fund for Higher Education of Gansu Province
   [2021B-008]
FX The authors would like to thank the participating centers and members.
   This study was supported by Gansu Province Science and Technology
   Foundation for Youths (No. 20JR10RA705) and Innovation Fund for Higher
   Education of Gansu Province (No. 2021B-008).Y.C. and F.C. conceptualized
   and designed the study. Y.C. and P.Y. acquired, analyzed, and
   interpreted the data. Y.C., X.S., and H.L. drafted/revised the work for
   intellectual content and context. Y.X. gave the final approval and
   over-all responsibility for the published work. All authors con-tributed
   to the article and approved the submitted version.This article does not
   contain any studies with human participants or animals performed by any
   of the authors.All data generated or analyzed during this study are
   included in this article.
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NR 49
TC 3
Z9 5
U1 1
U2 44
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-4973
EI 1473-5741
J9 ANTI-CANCER DRUG
JI Anti-Cancer Drugs
PD JUL
PY 2024
VL 35
IS 6
BP 525
EP 534
DI 10.1097/CAD.0000000000001601
PG 10
WC Oncology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pharmacology & Pharmacy
GA ZV0Q6
UT WOS:001277949300007
PM 38502854
DA 2026-05-27
ER

PT J
AU Biswal, S
   Barhwal, KK
   Das, D
   Dhingra, R
   Dhingra, N
   Nag, TC
   Hota, SK
AF Biswal, Suryanarayan
   Barhwal, Kalpana Kumari
   Das, Debashree
   Dhingra, Richa
   Dhingra, Nilima
   Nag, Tapas Chanda
   Hota, Sunil Kumar
TI Salidroside mediated stabilization of Bcl -XL prevents
   mitophagy in CA3 hippocampal neurons during hypoxia
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE Hypoxia; Lipofuscin; Mitophagy; Bcl-X-L; FUNDC1; Salidroside
ID INDUCED MEMORY IMPAIRMENT; CYTOCHROME-C RELEASE; CORTICAL-NEURONS;
   SPATIAL MEMORY; RECEPTOR; FUNDC1; ACCUMULATION; MECHANISMS; EXPRESSION;
   LIPOFUSCIN
AB Chronic hypoxic stress results in deposition of lipofuscin granules in the CA3 region of hippocampal neurons which contributes to neurodegeneration and accelerated neuronal aging. Oxidative stress and mitophagy during hypoxia are crucial to cause aggregation of these lipofuscin granules in hypoxic neurons. Salidroside, a glucoside derivative of beta-Tyrosol, has been reported to protect hypoxic neurons through maintenance of mitochondria] activity. The resent study is aimed at investigating the potential of Salidroside in preventing mitophagy during chronic hypoxia and identification of the molecular targets and underlying signaling mechanisms. In-silico analysis for interaction of salidroside with Bc1-X-L was carried out using VLife MDS software. The prophylactic efficacy of Salidroside for amelioration of global hypoxia induced neuronal aging was studied in adult male Sprague-Dawley rats exposed to hypobaric hypoxia simulating an altitude of 7600 m for 21 days. Salidroside was supplemented at a daily dose of 25 mg kg (-1)b.w. p.o. during hypoxic exposure. Ultra-structural and immune histological studies were conducted to study lipofuscin aggregation and mitophagy. In-silico findings on salidroside mediated stabilization of Bcl-xL were validated by investigating its effect on downstream signaling molecules involved in mitophagy. Administration of Salidroside reduced deposition of lipofuscin in hypoxic CA3 hippocampal neurons and prevented mitophagy. Salidroside stabilizes Bcl-x(L) in hypoxic neurons resulting in inhibition of PGAM5 phosphatase activity and maintenance of FUNDCI in phosphorylated state. Salidroside mediated inhibition of pFUNDCI dephosphorylation prevents FUNDC1-LC3 II interaction which is crucial for mitophagy. The present study demonstrates potential of Salidroside in preventing lipofuscin deposition during chronic hypoxic stress.
C1 [Biswal, Suryanarayan; Das, Debashree; Hota, Sunil Kumar] DRDO, Def Inst High Altitude Res, 56 APO, Leh Ladakh 901205, Jammu & Kashmir, India.
   [Barhwal, Kalpana Kumari] All India Inst Med Sci, Dept Physiol, Bhubaneswar 751019, Odisha, India.
   [Dhingra, Richa; Dhingra, Nilima] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh, India.
   [Nag, Tapas Chanda] All India Inst Med Sci, Dept Anat, New Delhi, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   High Altitude Research (DIHAR); All India Institute of Medical Sciences
   (AIIMS) Bhubaneswar; Panjab University; All India Institute of Medical
   Sciences (AIIMS) New Delhi
RP Barhwal, KK (corresponding author), All India Inst Med Sci, Dept Physiol, Bhubaneswar 751019, Odisha, India.
EM drkalpana2009@hotmail.com
RI NAG, TAPAS/R-6285-2019; Dhingra, Richa/AAU-4051-2021
OI NAG, TAPAS/0000-0002-6962-0844; Barhwal, Kalpana/0000-0001-7522-391X;
   Dhingra, Richa/0000-0003-1024-5338; Biswal,
   Suryanarayan/0000-0002-5847-3455
FU Department of Science and Technology, Govt of India
   [SR/WOS-A/LS-226/2016]; Defence Research & Development Organization,
   Ministry of Defence, Govt of India [S & T/14-15/DIH-123]
FX The present study was funded by Department of Science and Technology
   (SR/WOS-A/LS-226/2016), Govt of India and Defence Research & Development
   Organization, Ministry of Defence (S & T/14-15/DIH-123), Govt of India.
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NR 40
TC 28
Z9 29
U1 1
U2 51
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
EI 1095-953X
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD AUG
PY 2018
VL 116
BP 39
EP 52
DI 10.1016/j.nbd.2018.04.019
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GK7KW
UT WOS:000436384100004
PM 29723606
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Li, HS
   Ying, H
   Hu, AR
   Li, DZ
   Hu, YR
AF Li, Hongshan
   Ying, Hao
   Hu, Airong
   Li, Dezhou
   Hu, Yaoren
TI Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic
   Steatohepatitis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID LIVER; DISEASE; INFLAMMATION; NASH
AB A growing body of evidence has shown the beneficial effects of salidroside in cardiovascular and metabolic diseases. This study aimed to evaluate the therapeutic effects of salidroside on nonalcoholic steatohepatitis (NASH) in rats and explore the underlying mechanisms related to insulin signaling. A rat model of NASH was developed by high-fat diet for 14 weeks. From week 9 onward, the treatment group received oral salidroside (4.33mg/kg) daily for 6 weeks. Salidroside effectively attenuated steatosis and vacuolation of hepatic tissue, with a dramatic decrease in liver triglycerides and free fatty acid levels (P < 0.01). Dysregulation of FINS, FBG, HOMA-IR, ALT, and AST in serum was ameliorated with salidroside treatment (P < 0.01). In the liver, salidroside induced significant increases in key molecules in the insulin signaling pathway, such as phosphorylated insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (PI3K), and protein kinase B (PKB), with a significant decrease in SREBP-1c levels (P < 0.01). Therefore, salidroside effectively protected rats from high-fat-diet-induced NASH, which may be partially attributed to its effects on the hepatic insulin signaling pathway.
C1 [Li, Hongshan; Ying, Hao; Hu, Airong; Li, Dezhou; Hu, Yaoren] Ningbo 2 Hosp, Dept Hepatol, Ningbo 315010, Zhejiang, Peoples R China.
   [Li, Hongshan] Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China.
C3 Ningbo University
RP Li, HS (corresponding author), Ningbo 2 Hosp, Dept Hepatol, Ningbo 315010, Zhejiang, Peoples R China.; Li, HS (corresponding author), Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China.
EM lihongshan_1982@126.com
RI Hu, Ai-Rong/AAI-2894-2020; 胡, 爱荣/AAI-2894-2020
OI Li, Hongshan/0000-0002-9556-3556; 胡, 爱荣/0000-0002-8176-2714
FU National Natural Science Foundation of China [81503404]; Zhejiang
   Provincial Natural Science Foundation [LY15H270002]; Zhejiang Provincial
   Construction Project of Province; City Co-Building Key Disciplines
FX This study was supported by grants from the (1) National Natural Science
   Foundation of China (81503404), (2) Zhejiang Provincial Natural Science
   Foundation (LY15H270002), and (3) Zhejiang Provincial Construction
   Project of Province and City Co-Building Key Disciplines (2016-17).
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NR 23
TC 16
Z9 18
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 9651371
DI 10.1155/2017/9651371
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EL8FY
UT WOS:000394856900001
PM 28255329
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, Y
   Zhao, Q
AF Zhang, Yuan
   Zhao, Qing
TI Salidroside attenuates interleukin-1-induced inflammation in human
   osteoarthritis chondrocytes
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE inflammatory response; NF-B pathway; osteoarthritis (OA); salidroside
ID NF-KAPPA-B; NITRIC-OXIDE; GENE-EXPRESSION; SYNOVIAL-FLUID; CARTILAGE;
   COX-2; INHIBITION; ACTIVATION; MEDIATORS; PATHWAY
AB Salidroside, a bioactive constituent isolated from Rhodiola rosea, has been reported to have anti-inflammatory effects. However, the effects of salidroside on interleukin (IL)-1-stimulated osteoarthritis (OA) chondrocytes remain to be elucidated. Thus, this study aimed to evaluate the anti-inflammatory effects of salidroside on IL-1-stimulated human OA chondrocytes and explore its underlying mechanisms. Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E-2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1-stimulated chondrocytes (P<.05). In addition, salidroside also suppressed IL-1-induced matrix metalloproteinases production in human OA chondrocytes (P<.05). Furthermore, pretreatment with salidroside prevented IL-1-induced NF-B activation in OA chondrocytes (P<.05). In conclusion, the current study demonstrated that salidroside inhibited the IL-1-induced inflammatory response in OA chondrocytes via inhibition of NF-B activation.
C1 [Zhang, Yuan; Zhao, Qing] Henan Univ, Dept Rheumatol & Immunol, Huaihe Hosp, 115 Ximen St, Kaifeng 475000, Henan, Peoples R China.
C3 Henan University
RP Zhang, Y (corresponding author), Henan Univ, Dept Rheumatol & Immunol, Huaihe Hosp, 115 Ximen St, Kaifeng 475000, Henan, Peoples R China.
EM zy20181213@163.com
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NR 35
TC 18
Z9 21
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD FEB
PY 2019
VL 120
IS 2
BP 1203
EP 1209
DI 10.1002/jcb.27076
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HL6CW
UT WOS:000458822400015
PM 30270563
DA 2026-05-27
ER

PT J
AU Liu, Q
   Luo, QM
   Zhong, B
   Tang, KC
   Chen, XL
   Yang, SQ
   Li, XH
AF Liu, Qiao
   Luo, Qingman
   Zhong, Bin
   Tang, Kecheng
   Chen, Xueling
   Yang, Shengqian
   Li, Xiaohui
TI Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice
   by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Myocardial remodeling; Endothelin-1; PI3K/AKT/NF kappa B
ID CARDIAC-HYPERTROPHY; OXIDASE PATHWAY; ACTIVATION; RATS; INJURY
AB Myocardial remodeling, which occurs in the final stage of cardiovascular diseases such as hypertension, can ultimately result in heart failure. However, the pathogenesis of myocardial remodeling remains incompletely understood, and there is currently a lack of safe and effective treatment options. Salidroside, which is extracted from the plant Rhodiola rosea, shows remarkable antioxidant and anti-inflammatory characteristics. The purpose of this investigation was to examine the cardioprotective effect of salidroside on myocardial remodeling, and clarify the associated mechanism. Salidroside effectively attenuated cardiac dysfunction, myocardial hypertrophy, myocardial fibrosis, and cardiac inflammation, as well as renal injury and renal fibrosis in an animal model of deoxycortone acetate (DOCA)-salt-induced myocardial remodeling. The cardioprotective effect of salidroside was mediated by inhibiting the endothelin 1 and PI3K/AKT/NF kappa B signaling pathways. Salidroside was shown to inhibit the expression of endothelin1 in the hearts of mice treated with DOCA-salt. Additionally, it could prevent cardiomyocyte hypertrophy induced by endothelin-1 stimulation. Furthermore, Salidroside could effectively inhibit the excessive activation of the PI3K/AKT/NF kappa B pathway, which was caused by DOCA-salt treatment in mouse hearts and endothelin 1 stimulation in cardiomyocytes. Our study suggests that salidroside can be used as a therapeutic agent for the treatment of myocardial remodeling.
C1 [Liu, Qiao; Luo, Qingman; Zhong, Bin; Tang, Kecheng; Yang, Shengqian; Li, Xiaohui] Army Med Univ, Inst Mat Med, Coll Pharm, Chongqing 400038, Peoples R China.
   [Liu, Qiao; Luo, Qingman; Zhong, Bin; Tang, Kecheng; Yang, Shengqian; Li, Xiaohui] Army Med Univ, Coll Pharm, Dept Pharmaceut, Gao Tan Yan Str 30, Chongqing 400038, Peoples R China.
   [Liu, Qiao] Chongqing Med & Pharmaceut Coll, Dept Pharmaceut, Chongqing 401331, Peoples R China.
   [Chen, Xueling] Chongqing Univ Technol, Chongqing Sch Pharm & Bioengn, Chongqing 400054, Peoples R China.
   [Yang, Shengqian; Li, Xiaohui] Army Med Univ, Chongqing Engn Res Ctr Pharmacodynam Evaluat, Inst Mat Med, Coll Pharm, Gao Tan Yan St 30, Chongqing 400038, Peoples R China.
C3 Army Medical University; Army Medical University; Chongqing University
   of Technology; Army Medical University
RP Yang, SQ; Li, XH (corresponding author), Army Med Univ, Coll Pharm, Dept Pharmaceut, Gao Tan Yan Str 30, Chongqing 400038, Peoples R China.; Yang, SQ; Li, XH (corresponding author), Army Med Univ, Chongqing Engn Res Ctr Pharmacodynam Evaluat, Inst Mat Med, Coll Pharm, Gao Tan Yan St 30, Chongqing 400038, Peoples R China.
EM lqiao1023@163.com; qmlll567@163.com; a7726785@163.com;
   tkc958766833@163.com; 594528903@qq.com; saintchyang@163.com;
   xhl@tmmu.edu.cn
OI TANG, Kecheng/0009-0007-0437-5802
FU National Natural Scientific Foundation of China [82273921]; Science and
   Technology Research Program of Chongqing Municipal Education Commission
   [KJQN202212809]
FX This study was supported by grants of National Natural Scientific
   Foundation of China (No. 82273921) , the Science and Technology Research
   Program of Chongqing Municipal Education Commission (No. KJQN202212809)
   .
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NR 53
TC 10
Z9 12
U1 2
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JAN 5
PY 2024
VL 962
AR 176236
DI 10.1016/j.ejphar.2023.176236
EA DEC 2023
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DW3I1
UT WOS:001135074900001
PM 38048979
DA 2026-05-27
ER

PT J
AU Zheng, KL
   Sheng, ZQ
   Li, YF
   Lu, HH
AF Zheng, Koulong
   Sheng, Zhenqiang
   Li, Yefei
   Lu, Huihe
TI Salidroside inhibits oxygen glucose deprivation
   (OGD)/re-oxygenation-induced H9c2 cell necrosis through activating of
   Akt-Nrf2 signaling
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Oxygen glucose deprivation (OGD)/re-oxygenation; Salidroside; Nrf2; Akt
   and cardiomyocyte necrosis
ID MITOCHONDRIAL PERMEABILITY TRANSITION; CORONARY-ARTERY-DISEASE; INDUCED
   APOPTOSIS; OXIDATIVE STRESS; CYCLOPHILIN-D; IN-VITRO; DEATH; PROTECTS;
   EXPRESSION; PATHWAY
AB Oxygen glucose deprivation (OGD)/re-oxygenation has been applied to cultured cardiomyocytes to create a cellular model of ischemic heart damage. In the current study, we explored the potential role of salidroside against OGD/re-oxygenation-induced damage in H9c2 cardiomyocytes, and studied the underlying mechanisms. We found that OGD/re-oxygenation primarily induced necrosis in H9c2 cells, which was inhibited by salidroside. Salidroside suppressed OGD/re-oxygenation-induced reactive oxygen species (ROS) production, p53 mitochondrial translocation and cyclophilin D (Cyp-D) association as well as mitochondrial membrane potential (MMP) decrease in H9c2 cells. Meanwhile, salidroside activated Akt and promoted transcription of NF-E2-related factor 2 (Nrf2)-regulated genes (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1)). Significantly, Nrf2 shRNA knockdown or Ala inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells. These observations suggest that salidroside activates Nrf2-regulated anti-oxidant signaling, and protects against OGD/re-oxygenation-induced H9c2 cell necrosis via activation of Akt signaling. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Zheng, Koulong; Sheng, Zhenqiang; Li, Yefei; Lu, Huihe] Nantong Univ, Affiliated Hosp 2, Dept Cardiol, Nantong 226001, Peoples R China.
C3 Nantong University
RP Lu, HH (corresponding author), Nantong Univ, Affiliated Hosp 2, Dept Cardiol, 6 North Hai Er Xiang Rd, Nantong 226001, Peoples R China.
EM nantongluhuihe@163.com
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NR 35
TC 52
Z9 55
U1 0
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 15
PY 2014
VL 451
IS 1
BP 79
EP 85
DI 10.1016/j.bbrc.2014.07.072
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AN8OT
UT WOS:000340864200013
PM 25063033
DA 2026-05-27
ER

PT J
AU Zhang, B
   Tong, TB
   Zhou, JQ
AF Zhang, Bo
   Tong, Tiebi
   Zhou, Jingqun
TI Effect of Salidroside on Cardiac Function, Ventricular Remodeling, and
   Renin-angiotensin-aldosterone System Activity in Rats with Chronic Heart
   Failure
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE chronic heart failure; RAAS; salidroside; ventricular remodeling
ID EXPRESSION; ACE
AB Our work aimed to investigate the effect of salidroside on cardiac function, ventricular remodeling and renin-angiotensin-aldosterone system (RAAS) activity in rats with chronic heart failure (CHF). The rat model of CHF was constructed by ligating the anterior descending branch of left coronary artery. The model rats were randomly divided into model, 20 mg/kg salidroside and 40 mg/kg salidroside groups, 10 rats in each group. Then rats in sham operation group were selected. The 20 mg/kg salidroside and 40 mg/kg salidroside groups were given 20 and 40 mg/kg salinrosside, respectively, for four weeks. After treatment, compared with model group, in 40 mg/kg salidroside group, the left ventricular end diastolic diameter and left ventricular end systolic diameter were decreased, the left ventricular ejection fraction and left ventricular short axis fractional shortening were increased, the cardiac index and left ventricular mass index were decreased, the serum renin, angiotensin II and aldosterone levels were decreased, and the left ventricle angiotensin converting enzyme and angiotensin II type 1 receptor protein expression levels were also decreased (all P < 0.05). In conclusion, the salidroside treatment can inhibit the activation of RAAS, and reduce the ventricular remodeling, thus improving the cardiac function of CHF rats.
C1 [Zhang, Bo; Zhou, Jingqun] China Three Gorges Univ, Affiliated Renhe Hosp, Dept Cardiol, Yichang 443001, Peoples R China.
   [Tong, Tiebi] Shenyang 10th Peoples Hosp, Shenyang Chest Hosp, Cardiovasc Div, Shenyang 110044, Peoples R China.
C3 China Three Gorges University
RP Tong, TB (corresponding author), Shenyang 10th Peoples Hosp, Shenyang Chest Hosp, Cardiovasc Div, Shenyang 110044, Peoples R China.
EM tongtiebisy@sina.com
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NR 23
TC 0
Z9 0
U1 0
U2 2
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2020
VL 39
IS 12
BP 2424
EP 2429
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PQ8WC
UT WOS:000606822700014
DA 2026-05-27
ER

PT J
AU Kasprzyk, PG
   Tremaine, L
   Fahmi, OA
   Weng, JK
AF Kasprzyk, Philip G.
   Tremaine, Larry
   Fahmi, Odette A.
   Weng, Jing-Ke
TI In Vitro Evaluation of the Potential for Drug Interactions by
   Salidroside
SO NUTRIENTS
LA English
DT Article
DE salidroside; drug-drug interaction; CYP450; MAO-A; MAO-B; OATP
ID RHODIOLA-ROSEA; CYTOCHROME-P450 ENZYMES; CYP ENZYMES; INHIBITION;
   METABOLISM; RAT; SAFETY
AB Several studies utilizing Rhodiola rosea, which contains a complex mixture of phytochemicals, reported some positive drug-drug interaction (DDI) findings based on in vitro CYP450's enzyme inhibition, MAO-A and MAO-B inhibition, and preclinical pharmacokinetic studies in either rats or rabbits. However, variation in and multiplicity of constituents present in Rhodiola products is a cause for concern for accurately evaluating drug-drug interaction (DDI) risk. In this report, we examined the effects of bioengineered, nature-identical salidroside on the inhibition potential of salidroside on CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 utilizing human liver microsomes, the induction potential of salidroside on CYP1A2, CYP2B6 and CYP3A4 in cryopreserved human hepatocytes, the inhibitory potential of salidroside against recombinant human MAO-A and MAO-B, and the OATP human uptake transport inhibitory potential of salidroside using transfected HEK293-OATP1B1 and OATP1B3 cells. The results demonstrate that the bioengineered salidroside at a concentration exceeding the predicted plasma concentrations of <2 mu M (based on 60 mg PO) shows no risk for drug-drug interaction due to CYP450, MAO enzymes, or OATP drug transport proteins. Our current studies further support the safe use of salidroside in combination with other drugs cleared by CYP or MAO metabolism or OATP-mediated disposition.
C1 [Kasprzyk, Philip G.; Weng, Jing-Ke] DoubleRainbow Biosci Inc, Lexington, MA 02421 USA.
   [Tremaine, Larry] Tremaine DMPK Consulting LLC, Merritt Isl, FL 32899 USA.
   [Fahmi, Odette A.] DDI Edge Consulting LLC, Ft Lauderdale, FL 33308 USA.
   [Weng, Jing-Ke] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA.
   [Weng, Jing-Ke] MIT, Dept Biol, Cambridge, MA 02139 USA.
C3 Massachusetts Institute of Technology (MIT); Whitehead Institute;
   Massachusetts Institute of Technology (MIT)
RP Kasprzyk, PG (corresponding author), DoubleRainbow Biosci Inc, Lexington, MA 02421 USA.
EM kasprzyk@doublerainbowbio.com; tremainelm@gmail.com;
   o.fahmi@pharmadvisors.com; jingke.weng@doublerainbowbio.com
RI Weng, Jing-Ke/V-5934-2019
CR [Anonymous], About us
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NR 24
TC 9
Z9 9
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2023
VL 15
IS 17
AR 3723
DI 10.3390/nu15173723
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R4TG6
UT WOS:001064279600001
PM 37686755
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, N
   Zuo, Z
   Meng, T
   Liu, YL
   Zheng, XW
   Ma, YS
AF Wang, Nan
   Zuo, Zhuan
   Meng, Tong
   Liu, Yuliang
   Zheng, Xiwei
   Ma, Yongsheng
TI Salidroside alleviates simulated microgravity-induced bone loss by
   activating the Nrf2/HO-1 pathway
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Microgravity-induced bone loss; Salidroside; Oxidative stress; Nrf2/HO-1
   pathway
ID OXIDATIVE STRESS-RESPONSE; SKELETAL CHANGES; DISORDERS; MODEL
AB BackgroundBone loss caused by microgravity exposure presents a serious threat to the health of astronauts, but existing treatment strategies have specific restrictions. This research aimed to investigate whether salidroside (SAL) can mitigate microgravity-induced bone loss and its underlying mechanism.MethodsIn this research, we used hindlimb unloading (HLU) and the Rotary Cell Culture System (RCCS) to imitate microgravity in vivo and in vitro.ResultsThe results showed that salidroside primarily enhances bone density, microstructure, and biomechanical properties by stimulating bone formation and suppressing bone resorption, thereby preserving bone mass in HLU rats. In MC3T3-E1 cells cultured under simulated microgravity in rotary wall vessel bioreactors, the expression of osteogenic genes significantly increased after salidroside administration, indicating that salidroside can promote osteoblast differentiation under microgravity conditions. Furthermore, the Nrf2 inhibitor ML385 diminished the therapeutic impact of salidroside on microgravity-induced bone loss. Overall, this research provides the first evidence that salidroside can mitigate bone loss induced by microgravity exposure through stimulating the Nrf2/HO-1 pathway.ConclusionThese findings indicate that salidroside has great potential for treating space-related bone loss in astronauts and suggest that Nrf2/HO-1 is a viable target for counteracting microgravity-induced bone damage.
C1 [Wang, Nan; Zuo, Zhuan; Liu, Yuliang; Zheng, Xiwei; Ma, Yongsheng] Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Harbin, Peoples R China.
   [Meng, Tong] Xian City First Hosp, Dept Orthoped Surg, Xian, Peoples R China.
C3 Harbin Medical University
RP Ma, YS (corresponding author), Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Harbin, Peoples R China.
EM 600546@hrbmu.edu.cn
FU Heilongjiang Province Post-doctoral Foundation Grant
FX We are particularly grateful to all the people who have given us help on
   our article.
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NR 44
TC 5
Z9 6
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD SEP 2
PY 2024
VL 19
IS 1
AR 531
DI 10.1186/s13018-024-05030-1
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA E2Z8E
UT WOS:001301741300003
PM 39218922
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fu, SQ
   Yan, MJ
   Fan, QY
   Xu, JT
AF Fu, Shengqiang
   Yan, Mengjun
   Fan, Qiaoyun
   Xu, Juntao
TI Salidroside promotes osteoblast proliferation and differentiation via
   the activation of AMPK to inhibit bone resorption of knee osteoarthritis
   mice
SO TISSUE & CELL
LA English
DT Article
DE Salidroside; Osteoblast; Bone resorption; AMPK; Knee osteoarthritis
ID PROTEIN-KINASE; PATHWAY; ADIPOGENESIS; OSTEOGENESIS; APOPTOSIS; GROWTH;
   CELLS
AB Aim: Balance between osteoclasts and osteoblasts was important for bone development and regeneration, which attracted wide attention. To investigate whether the pro-restorative effect of salidroside (SAL) on knee osteo-arthritis in mice was associated with adenosine monophosphate-activated protein kinase (AMPK). Methods: MC3T3-E1 cells were used to perform CCK8, ALP measurement, alizarin red assay and western blot. Mouse model with knee osteoarthritis was constructed and received the treatment of SAL. Body weight, arthritis index, and inflammatory factors were recorded and measured. The paraffin sections of knee bone joints were performed by HE and immunohistochemical staining. Western blot was carried out. CCK8, EDU and flow cytometry were used to analyzed the inhibitory effect of salidroside on osteoclast. Results: We found that salidroside could promote osteoblast proliferation and differentiation, and upregulate COL1A1, RUNX2 and OCN proteins and increase ALP content and phosphorylation level of AMPK. In vivo assays showed that salidroside inhibited inflammatory reaction, improved pathological condition. Salidroside reduced TRAP and NFATc1 expression, and increased the expression of ALP, COL1A1, RUNX2 and OCN proteins. p-AMPK protein was upregulated by salidroside treatment. We also performed in vitro assay, and found salidroside could inhibit proliferation of osteoclast and increase apoptosis of osteoclast. Conclusion: In a word, salidroside promoted osteoblast proliferation and differentiation through AMPK activation to further inhibit osteoclast bone resorption, so as to achieve the purpose of relieving knee osteoarthritis.
C1 [Fu, Shengqiang; Xu, Juntao] Yantaishan Hosp, Ward Hand Surg 1, Yantai, Shandong, Peoples R China.
   [Yan, Mengjun] Yantai Raphael Biotechnol Co Ltd, Yantai, Shandong, Peoples R China.
   [Fan, Qiaoyun] Yantaishan Hosp, Dept Intervent Operat, Yantai, Shandong, Peoples R China.
   [Fu, Shengqiang] Yantaishan Hosp, Ward Hand Surg 1, Sci & Technol Ave 10087, Yantai 264000, Shandong, Peoples R China.
RP Fu, SQ (corresponding author), Yantaishan Hosp, Ward Hand Surg 1, Sci & Technol Ave 10087, Yantai 264000, Shandong, Peoples R China.
EM fsq512100@126.com
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NR 49
TC 10
Z9 15
U1 3
U2 27
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0040-8166
J9 TISSUE CELL
JI Tissue Cell
PD DEC
PY 2022
VL 79
AR 101917
DI 10.1016/j.tice.2022.101917
EA SEP 2022
PG 10
WC Anatomy & Morphology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Cell Biology
GA 4Z4RL
UT WOS:000862197900004
PM 36095933
OA hybrid
DA 2026-05-27
ER

PT J
AU Li, W
   Yang, SX
   Xie, ZP
   Lu, H
   Ling, JJ
   Cheng, WD
AF Li, Wei
   Yang, Sixia
   Xie, Zeping
   Lu, Hui
   Ling, Junjun
   Cheng, Weidong
TI Neuroprotective Effects of Salidroside Against Beta-Amyloid-Induced
   Cognitive Impairment in Alzheimer's Disease Mice Through the PKC/p38MAPK
   Pathway
SO JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
LA English
DT Article
DE Salidroside; Alzheimer's Disease; PKC; p38MAPK
ID INDUCED NEUROTOXICITY; INDUCED APOPTOSIS; RHODIOLA-ROSEA; PC12 CELLS;
   ACTIVATION; PEPTIDE; INVOLVEMENT; TOXICITY; PROTECTS; DEFICITS
AB Alzheimer's disease (AD) is a common neurodegenerative disease as well as the main cause of dementia. A progressive cognitive decline with age is considered as the major manifestation of AD. Amyloid beta-peptide (A beta) is one of the primary causes leading to cognitive dysfunction in AD. Recent studies have suggested that the activation of PKC/p38MAPK pathway is related to the neurotoxicity induced by beta-amyloid. Salidroside is the major active component of Rhodiola crenulata, has been reported with widely neuroprotective effects. The protective effects of salidroside against beta-amyloid induced neural apoptosis via the MAPKs pathway has been confirmed in the vitro study. The present study aimed to investigate the neuroprotective effects of salidroside through the PKC/p38MAPK pathway in beta-amyloid induced AD mice. The results by Y maze showed that salidroside improved A beta-induced cognitive impairment. Nissl staining results showed that salidroside affected neuronal damage in hippocampus and cerebral cortex of AD mice. Western blot results revealed that salidroside enhanced protein expression of p-PKC, whereas it suppressed protein expression of p-p38MAPK, Bax and cleaved caspase-3. Thus, the present results demonstrated that salidroside ameliorated cognitive dysfunction in A beta(25-35) induced AD mice. And the effects on protein expression of p-PKC and p-p38MAPK contributed to the neuroprotective effects of salidroside against neural apoptosis in AD mice.
C1 [Li, Wei; Yang, Sixia; Xie, Zeping; Lu, Hui; Cheng, Weidong] Southern Med Univ, Dept Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
   [Ling, Junjun] Third Mil Med Univ, Inst Canc, Xinqiao Hosp, Chongqing 400037, Peoples R China.
C3 Southern Medical University - China; Army Medical University
RP Cheng, WD (corresponding author), Southern Med Univ, Dept Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
RI LU, HUI/HME-0335-2023; Cheng, Weidong/LMP-6222-2024
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NR 31
TC 5
Z9 5
U1 2
U2 40
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 2157-9083
EI 2157-9091
J9 J BIOMATER TISS ENG
JI J. Biomater. Tissue Eng.
PD FEB
PY 2020
VL 10
IS 2
BP 212
EP 217
DI 10.1166/jbt.2020.2223
PG 6
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ML4MC
UT WOS:000549441100011
DA 2026-05-27
ER

PT J
AU Wang, N
   Song, JY
   Zhou, G
   Li, WL
   Ma, HY
AF Wang, Nan
   Song, Jiyang
   Zhou, Gang
   Li, Wenli
   Ma, Huiyuan
TI Mechanism of salidroside relieving the acute hypoxia-induced myocardial
   injury through the PI3K/Akt pathway
SO SAUDI JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Salidroside; PI3K/Akt pathway; Acute hypoxia; Hypobaric hypoxia;
   Myocardial injury
ID SIGNALING PATHWAY; APOPTOSIS; PROLIFERATION; AUTOPHAGY; LIVER
AB Objective: The objective was to investigate the anti-inflammatory effects of salidroside through the PI3K/Akt signaling pathway and its protective effects on acute hypoxia-induced myocardial injury in rats.
   Methods: A total of 24 healthy Sprague-Dawley male rats were selected as the experimental subjects. All rats were divided into 4 groups by using the random number table method, with 6 rats in each group. The groups included the normal control group, the salidroside group, the hypobaric hypoxia group, and the hypobaric hypoxia + salidroside group. Rats in the salidroside group were fed in the original animal laboratory and were intragastrically administered with salidroside every morning at a dosage of 35 mg/kg. Rats in the normal control group were intragastrically administered with an equal dosage of saline. Rats in the hypobaric hypoxia + salidroside group were intragastrically administered with salidroside every morning at a dosage of 35 mg/kg, who were fed in the hypoxic experiment module for animals. The altitude was increased to 4000 m, and the rats were kept in the module for 24 h. Rats in the hypobaric hypoxia group were intragastrically administered with an equal dosage of saline in the same environment, and the altitude was increased to 4000 m after administration. Parameters of blood gas analysis, histopathological changes in cardiac tissues, cardiac indexes, and inflammatory factors IL-6 and TNF-alpha levels of rats in groups were compared.
   Results: 1. The cardiac indexes of rats in groups were compared. The differences between the hypobaric hypoxia group and the hypobaric hypoxia + salidroside group were statistically significant (P < 0.05). 2. The results of blood gas analysis of rats in groups were compared. The differences between the hypobaric hypoxia group and the hypobaric hypoxia + salidroside group were significantly different (P < 0.05). 3. In the hypobaric hypoxia group, the myocardial cells of rats were arranged disorderly and shaped differently, with cases such as edema, degeneration, necrosis, nucleus pyknosis, and massive infiltration of inflammatory cells. In the hypobaric hypoxia + salidroside group, the above-mentioned pathological changes in myocardial cells were relieved. 4. Compared with the hypobaric hypoxia group, in the hypobaric hypoxia + salidroside group, the concentrations of IL-6 and TNF-alpha in rats decreased apparently, and the differences were statistically significant (P < 0.05).
   Conclusion: Salidroside had the repairing and protective effects on the hypobaric hypoxia-induced myocardial injuries in rats. The application of salidroside could reduce the inflammatory responses of rats with hypobaric hypoxia-induced myocardial injuries through PI3K/Akt signaling pathway, thereby protecting the myocardial cells. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
C1 [Wang, Nan; Song, Jiyang; Zhou, Gang; Li, Wenli; Ma, Huiyuan] Gansu Prov Hosp, Dept Cardiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
RP Ma, HY (corresponding author), Gansu Prov Hosp, Dept Cardiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM mahuiyuangph@163.com
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NR 15
TC 20
Z9 26
U1 1
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1319-562X
EI 2213-7106
J9 SAUDI J BIOL SCI
JI Saudi J. Biol. Sci.
PD JUN
PY 2020
VL 27
IS 6
BP 1533
EP 1537
DI 10.1016/j.sjbs.2020.04.035
PG 5
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA LT7NL
UT WOS:000537253300015
PM 32489291
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Yang, SX
   Wang, LS
   Zeng, Y
   Wang, Y
   Pei, TT
   Xie, ZP
   Xiong, QW
   Wei, H
   Li, WX
   Li, JQ
   Su, Q
   Wei, DF
   Cheng, WD
AF Yang, Sixia
   Wang, Linshuang
   Zeng, Yi
   Wang, Yong
   Pei, Tingting
   Xie, Zeping
   Xiong, Qiaowu
   Wei, Hui
   Li, Wenxu
   Li, Jiaqi
   Su, Qian
   Wei, Dongfeng
   Cheng, Weidong
TI Salidroside alleviates cognitive impairment by inhibiting ferroptosis
   via activation of the Nrf2/GPX4 axis in SAMP8 mice
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; Alzheimer's disease; Ferroptosis; CD8+T cells; Nrf2
ID MOUSE MODEL; ALZHEIMERS; CELLS; PATHOLOGY; BEHAVIOR; BRAINS; MAZE; TAU
AB Background: Alzheimer's disease (AD) is a neurogenerative disease and remains no effective method for stopping its progress. Ferroptosis and adaptive immunity have been proven to contribute to AD pathogenesis. Salidroside exhibits neuroprotective and immunomodulatory effects. However, the underlying mechanisms linking salidroside, ferroptosis, and adaptive immunity in AD remain uncertain. Purpose: The objective of this study is to explore the neuroprotective effects and the potential molecular mechanisms of salidroside against neuronal ferroptosis and CD8+ T cell infiltration in senescence-accelerated mouse prone 8 (SAMP8) mice. Study design and methods: SAMP8 mice were employed as an AD model and were treated with salidroside for 12 weeks. Behavioral tests, immunohistochemistry, HE and Nissl staining, immunofluorescence, transmission electron microscopy, quantitative proteomics, bioinformatic analysis, flow cytometry, iron staining, western blotting, and molecular docking were performed. Results: Treatment with salidroside dose-dependently attenuated cognitive impairment, reduced the accumulation of A beta plaques and restored neuronal damage. Salidroside also suppressed the infiltration of CD8+T cells, oxidative stress, and inflammatory cytokines, and improved mitochondrial metabolism, iron metabolism, lipid metabolism, and redox in the SAMP8 mice brain. The administration of salidroside decreased iron deposition, reduced TFR1, and ACSL4 protein expression, upregulated SLC7A11, and GPX4 protein expression, and promoted the Nrf2/GPX4 axis activation. Conclusion: In conclusion, neuronal ferroptosis and CD8+T cells are involved in the process of cognitive impairment in SAMP8 mice. Salidroside alleviates cognitive impairment and inhibits neuronal ferroptosis. The underlying mechanisms may involve the Nrf2/GPX4 axis activation and reduction in CD8+T cells infiltration. This study provides some evidence for the roles of salidroside in adaptive immunity and neuronal ferroptosis in SAMP8 mice.
C1 [Yang, Sixia; Wang, Yong; Cheng, Weidong] Southern Med Univ, Zhu Jiang Hosp, Dept Pharm, Guangzhou 510260, Peoples R China.
   [Yang, Sixia; Zeng, Yi; Pei, Tingting; Xie, Zeping; Xiong, Qiaowu; Wei, Hui; Li, Wenxu; Li, Jiaqi; Su, Qian; Cheng, Weidong] Southern Med Univ, Sch Tradit Chinese Med, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China.
   [Wang, Linshuang; Wei, Dongfeng] China Acad Chinese Med Sci, Inst Basic Res Clin Med, 16 Nanxiao St, Beijing 100700, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Institute of Basic Research In Clinical Medicine, CACMS; China
   Academy of Chinese Medical Sciences
RP Cheng, WD (corresponding author), Southern Med Univ, Zhu Jiang Hosp, Dept Pharm, Guangzhou 510260, Peoples R China.; Cheng, WD (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China.; Wei, DF (corresponding author), China Acad Chinese Med Sci, Inst Basic Res Clin Med, 16 Nanxiao St, Beijing 100700, Peoples R China.
EM weidongfeng@aliyun.com; chengweidong888@sina.com
RI Li, Jiaqi/JZD-5965-2024; Cheng, Weidong/LMP-6222-2024
FU National Natural Science Founda-tion of China [82174149, 81973641,
   82174210]; National Key Research and Development Program of China
   [2018YFC1704404]; Major National Science and Technol-ogy Projects
   Creation of Major New Drugs [2013ZX09103002-002]
FX Acknowledgments This research was funded by the National Natural Science
   Founda-tion of China (grant number: 82174149, 81973641, and 82174210) ,
   the National Key Research and Development Program of China (grant number
   2018YFC1704404) , and Major National Science and Technol-ogy Projects
   Creation of Major New Drugs (grant number 2013ZX09103002-002) .
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NR 49
TC 129
Z9 150
U1 19
U2 159
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2023
VL 114
AR 154762
DI 10.1016/j.phymed.2023.154762
EA MAR 2023
PG 15
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA D7OI8
UT WOS:000970580500001
PM 36965372
OA hybrid
DA 2026-05-27
ER

PT J
AU Wu, CY
   Tang, LH
   Ni, XJ
   Xu, TT
   Fang, QQ
   Xu, L
   Ma, WJ
   Yang, XM
   Sun, HL
AF Wu, Changyue
   Tang, Longhai
   Ni, Xuejun
   Xu, Tongtong
   Fang, Qingqing
   Xu, Lai
   Ma, Wenjing
   Yang, Xiaoming
   Sun, Hualin
TI Salidroside Attenuates Denervation-Induced Skeletal Muscle Atrophy
   Through Negative Regulation of Pro-inflammatory Cytokine
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE denervation; muscle atrophy; inflammation; salidroside; interleukin 6
ID FACTOR-KAPPA-B; PROTEIN BREAKDOWN; INTERLEUKIN-6; INHIBITION;
   ACTIVATION; PATHWAY; EXPRESSION; SYSTEM; RATS; IL-6
AB Skeletal muscle atrophy is associated with pro-inflammatory cytokines. Salidroside is a biologically active ingredient of Rhodiola rosea, which exhibits anti-inflammatory property. However, there is little known about the effect of salidroside on denervation-induced muscle atrophy. Therefore, the present study aimed to determine whether salidroside could protect against denervation-induced muscle atrophy and to clarify potential molecular mechanisms. Denervation caused progressive accumulation of inflammatory factors in skeletal muscle, especially interleukin 6 (IL6) and its receptor, and recombinant murine IL6 (rmIL6) local infusion could induce target muscle atrophy, suggesting that denervation induced inflammation in target muscles and the inflammation may trigger muscle wasting. Salidroside alleviated denervation-induced muscle atrophy and inhibited the production of IL6. Furthermore, the inhibition of phosphorylation of signal transducer and activator of transcription 3 (STAT3), and the decreased levels of suppressor of cytokine signaling (SOCS3), muscle RING finger protein-1 (MuRF1), atrophy F-box (atrogin-1), microtubule-associated protein light chain 3 beta (LC3B) and PTEN-induced putative kinase (PINK1) were observed in denervated muscles that were treated with salidroside. Finally, all of these responses to salidroside were replicated in neutralizing antibody against IL6. Taken together, these results suggest that salidroside alleviates denervation-induced inflammation response, thereby inhibits muscle proteolysis and muscle atrophy. Therefore, it was assumed that salidroside might be a potential therapeutic candidate to prevent muscle wasting.
C1 [Wu, Changyue; Fang, Qingqing; Xu, Lai; Ma, Wenjing; Yang, Xiaoming; Sun, Hualin] Nantong Univ, Key Lab Neuroregenerat Jiangsu, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China.
   [Wu, Changyue; Fang, Qingqing; Xu, Lai; Ma, Wenjing; Yang, Xiaoming; Sun, Hualin] Nantong Univ, Minist Educ, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China.
   [Wu, Changyue; Xu, Tongtong] Nantong Univ, Sch Med, Nantong, Peoples R China.
   [Tang, Longhai] Suzhou Blood Ctr, Dept Blood Component Preparat, Suzhou, Peoples R China.
   [Ni, Xuejun] Nantong Univ, Dept Ultrasound, Affiliated Hosp, Nantong, Peoples R China.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University
RP Sun, HL (corresponding author), Nantong Univ, Key Lab Neuroregenerat Jiangsu, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China.; Sun, HL (corresponding author), Nantong Univ, Minist Educ, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China.
EM sunhl@ntu.edu.cn
RI sun, hualin/AAX-6391-2021; Yang, Xiaoming/GMW-7312-2022; fang,
   qingqing/GZK-4330-2022
FU National Key Research and Development Program of China [2017YFA0104703];
   National Natural Science Foundation of China [81871554, 81671230,
   81301628]; 973 Program [2014CB542202, 2014CB542203]; Jiangsu Provincial
   Key Medical Center; Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD); Fund of Doctoral Start-up of
   Nantong University [15B18, 17ZZ040, 18ZXY192]; Jiangsu College Students
   Innovation and Entrepreneurship Training Program [201710304029Z]
FX This work was supported by the National Key Research and Development
   Program of China (Grant No. 2017YFA0104703), National Natural Science
   Foundation of China (Grant Nos. 81871554, 81671230, and 81301628), the
   973 Program (Grant Nos. 2014CB542202 and 2014CB542203), a project funded
   by Jiangsu Provincial Key Medical Center, the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD), Fund of
   Doctoral Start-up of Nantong University (Grant Nos. 15B18, 17ZZ040, and
   18ZXY192) and Jiangsu College Students Innovation and Entrepreneurship
   Training Program (Grant No. 201710304029Z).
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NR 43
TC 50
Z9 54
U1 1
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 25
PY 2019
VL 10
AR 665
DI 10.3389/fphys.2019.00665
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA IF6QT
UT WOS:000473205900001
PM 31293430
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Qi, ZL
   Zhang, Y
   Qi, SM
   Ling, LF
   Gui, L
   Yan, L
   Lv, J
   Li, Q
AF Qi, Zhilin
   Zhang, Yao
   Qi, Shimei
   Ling, Liefeng
   Gui, Lin
   Yan, Liang
   Lv, Jun
   Li, Qiang
TI Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation
   of SirT1 during Inflammation
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CHROMATIN PROTEIN HMGB1; KAPPA-B; ACTIVATION; CELLS; TRANSLOCATION;
   RECEPTOR; PATHWAY
AB HMGB1, a highly conserved nonhistone DNA-binding protein, plays an important role in inflammatory diseases. Once released to the extracellular space, HMGB1 acts as a proinflammatory cytokine that triggers inflammatory reaction. Our previous study showed that salidroside exerts anti-inflammatory effect via inhibiting the JAK2-STAT3 signalling pathway. However, whether salidroside inhibits the release of HMGB1 is still unclear. In this study, we aim to study the effects of salidroside on HMGB1 release and then investigate the potential molecular mechanisms. In an experimental rat model of sepsis caused by CLP, salidroside administration significantly attenuated lung injury and reduced the serum HMGB1 level. In RAW264.7 cells, we investigated the effects of salidroside on LPS-induced HMGB1 release and then explored the underlying molecular mechanisms. We found that salidroside significantly inhibited LPS-induced HMGB1 release, and the inhibitory effect was correlated with the HMGB1 acetylation levels. Mechanismly, salidroside inhibits HMGB1 acetylation through the AMPK-SirT1 pathway. In addition, SirT1 overexpression attenuated LPS-induced HMGB1 acetylation and nucleocytoplasmic translocation. Furthermore, in SirT1 shRNA plasmid-transfected cells, salidroside treatment enhanced SirT1 expression and reduced LPS-activated HMGB1 acetylation and nucleocytoplasmic translocation. Collectively, these results demonstrated that salidroside might reduce HMGB1 release through the AMPK-SirT1 signalling pathway and suppress HMGB1 acetylation and nucleocytoplasmic translocation.
C1 [Qi, Zhilin; Zhang, Yao; Qi, Shimei; Ling, Liefeng; Yan, Liang; Lv, Jun] Wannan Med Coll, Dept Biochem, Wuhu, Anhui, Peoples R China.
   [Qi, Zhilin; Zhang, Yao; Qi, Shimei; Ling, Liefeng; Yan, Liang; Lv, Jun; Li, Qiang] Anhui Prov Key Lab Act Biol Macromol, Wuhu, Anhui, Peoples R China.
   [Gui, Lin] Wannan Med Coll, Dept Microbiol & Immunol, Wuhu, Anhui, Peoples R China.
C3 Wannan Medical College; Wannan Medical College
RP Qi, ZL (corresponding author), Wannan Med Coll, Dept Biochem, Wuhu, Anhui, Peoples R China.; Qi, ZL (corresponding author), Anhui Prov Key Lab Act Biol Macromol, Wuhu, Anhui, Peoples R China.
EM 422627721@qq.com
FU National Nature Science Foundation of China [81601380]; Natural Science
   Research Project of Anhui Colleges and Universities [KJ2016SD59];
   Provincial Foundation for Excellent Young Talents of Colleges and
   Universities of Anhui Province [gxyqZD2016173]; Anhui Province Key
   Laboratory of Active Biological Macromolecules [1306C083008]; Key
   Scientific Research Project of Wannan Medical College [WK2015Z01]
FX The present study was supported by the National Nature Science
   Foundation of China (Grant no. 81601380), Natural Science Research
   Project of Anhui Colleges and Universities (Grant no. KJ2016SD59),
   Provincial Foundation for Excellent Young Talents of Colleges and
   Universities of Anhui Province (Grant no. gxyqZD2016173), Anhui Province
   Key Laboratory of Active Biological Macromolecules (Grant no.
   1306C083008), and Key Scientific Research Project of Wannan Medical
   College (Grant no. WK2015Z01). The authors would like to thank Associate
   Professor Yinhua Liu for assisting with the experiment.
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NR 35
TC 30
Z9 35
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
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PG 11
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FO4OA
UT WOS:000416822900001
PM 29333216
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Jiang, L
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AF Jiang, Lu
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   Zhuang, Mingyang
   Yang, Dongdong
TI Salidroside attenuates sepsis-associated acute lung injury through
   PPP1R15A mediated endoplasmic reticulum stress inhibition
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Sepsis; Acute lung injury; Salidroside; Protein phosphatase 1 regulatory
   subunit 15A
ID DEXAMETHASONE; ACID
AB Background: This study explored the role and mechanism of salidroside in sepsis-associated acute lung injury (ALI).Method: Sepsis-associated ALI in rats was induced by cecal ligation and perforation method, while lipopoly-saccharide (LPS) was used to stimulate cell model. After the treatment of salidroside and dexamethasone (DEX), hematoxylin and eosin staining was applied to evaluate the rat lung injury. Next, the number of total cells and neutrophils in rat bronchoalveolar lavage fluid (BALF) was counted, and the lung wet/dry (W/D) ratio and water content were measured. The neutrophil elastase activity and inflammatory factor levels in BALF were detected by Elastase Assay kit and ELISA. The expressions of PPP1R15A and endoplasmic reticulum (ER) stress-related genes were detected by quantitative reverse transcription polymerase chain reaction and western blot. And the effects of silenced PPP1R15A and tauroursodeoxycholic acid (TUDCA) on cell viability, apoptosis and endoplasmic reticulum (ER) stress were determined by cell counting kit-8 assay, flow cytometry and western blot.Result: The lung injury, inflammation and edema in sepsis model rats were alleviated by salidroside and DEX, meanwhile salidroside increased the viability and inhibited apoptosis in LPS-treated cells. The expression of PPP1R15A was decreased in sepsis models and increased by salidroside, and salidroside down-regulated the ER stress-related protein expressions in vitro and in vivo. Silenced PPP1R15A reversed the effect of salidroside on cell viability, apoptosis and ER stress, whereas TUDCA could counteract the above effect of silenced PPP1R15A.Conclusion: Salidroside targeted PPP1R15A to ameliorate lung injury in sepsis through inhibiting ER stress.
C1 [Jiang, Lu; Xu, Liying; Zheng, Lanzhi; Yang, Dongdong] Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Emergency Dept, Hangzhou, Zhejiang, Peoples R China.
   [Wang, Yuan] Hangzhou Med Coll, Sch Lab Med, Hangzhou, Peoples R China.
   [Zhuang, Mingyang] Zhejiang Chinese Med Univ, Clin Coll 1, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Hangzhou Medical College; Zhejiang
   Chinese Medical University
RP Yang, DD (corresponding author), Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Emergency Dept, Hangzhou, Zhejiang, Peoples R China.
EM yangdongdong_ydd@163.com
OI Dongdong, Yang/0000-0002-2969-6158
FU Zhejiang TCM Science and Technology Plan [2020ZB070]; National Natural
   Science Foundation of China (NSFC) [82104763]
FX Funding This work was supported by Zhejiang TCM Science and Technology
   Plan, [Grant Number: 2020ZB070] Project name: Mechanism of Xiao-qinglong
   Decoction in treating acute respiratory distress syndrome induced by
   sepsis by regulating the balance of extracellular histone HATs/HDACs;
   and National Natural Science Foundation of China (NSFC) 82104763, based
   on the balance regulation of extracellular histone HATs/HDACs to explore
   the mechanism of action of xiaoqing-long decoction on acute.
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NR 36
TC 19
Z9 24
U1 2
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD OCT 1
PY 2022
VL 71
AR 116865
DI 10.1016/j.bmc.2022.116865
EA AUG 2022
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 4F1NH
UT WOS:000848281800003
PM 35985062
DA 2026-05-27
ER

PT J
AU Magani, SKJ
   Mupparthi, SD
   Gollapalli, BP
   Shukla, D
   Tiwari, AK
   Gorantala, J
   Yarla, NS
   Tantravahi, S
AF Magani, Sri Krishna Jayadev
   Mupparthi, Sri Durgambica
   Gollapalli, Bhanu Prakash
   Shukla, Dhananjay
   Tiwari, A. K.
   Gorantala, Jyotsna
   Yarla, Nagendra Sastry
   Tantravahi, Srinivasan
TI Salidroside - Can it be a Multifunctional Drug?
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE Salidroside; tyrosol; cancer; diabetis; 4-hydroxyphenyl acetaldehyde
   (4-HPAA); glucronidation
ID RHODIOLA-ROSEA EXTRACTS; METABOLITE P-TYROSOL; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; FATTY-ACID; GENETIC PREDISPOSITION;
   LIPID-METABOLISM; PC12 CELLS; IN-VITRO; CANCER
AB Background: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It exhibits diverse biological and pharmacological properties. In the last decade, enormous research is conducted to explore the medicinal properties of salidroside; this research reported many activities like anti-cancer, anti-oxidant, anti-aging, anti-diabetic, anti-depressant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, etc.
   Objective: Despite its multiple pharmacological effects, a comprehensive review detailing its metabolism and therapeutic activities is still missing. This review aims to provide an overview of the metabolism of salidroside, its role in alleviating different metabolic disorders, diseases and its molecular interaction with the target molecules in different conditions. This review mostly concentrates on the metabolism, biological activities and molecular pathways related to various pharmacological activities of salidroside.
   Conclusion: Salidroside is produced by a three-step pathway in the plants with tyrosol as an intermediate molecule. The molecule is biotransformed into many metabolites through phase I and II pathways. These metabolites, together with a certain amount of salidroside may be responsible for various pharmacological functions. The salidroside based inhibition of PI3k/AKT, JAK/ STAT, and MEIC/ERK pathways and activation of apoptosis and autophagy are the major reasons for its anti-cancer activity. AMPK pathway modulation plays a significant role in its anti-diabetic activity. The neuroprotective activity was linked with decreased oxidative stress and increased antioxidant enzymes, Nrf2/HO-1 pathways, decreased inflammation through suppression of NF-kappa beta pathway and PI3k/AKT pathways. These scientific findings will pave the way to clinically translate the use of salidroside as a multi-functional drug for various diseases and disorders in the near future.
C1 [Magani, Sri Krishna Jayadev] Shiv Nadar Univ, Sch Nat Sci, Dept Life Sci, Greater Noida, India.
   [Mupparthi, Sri Durgambica] GITAM, Dept Biotechnol, GITAM Inst Sci, Visakhapatnam, Andhra Pradesh, India.
   [Gollapalli, Bhanu Prakash] Neelakanta Vidyapeeth, Hyderabad, India.
   [Shukla, Dhananjay] Guru Ghasidas Vishwavidyalaya, Dept Biotechnol, Bilaspur, India.
   [Tiwari, A. K.] Dr Bhanvar Singh Porte Govt Coll, Dept Zool, Pendra Bilaspur, India.
   [Gorantala, Jyotsna] Govt India, Dept Biotechnol, New Delhi, India.
   [Yarla, Nagendra Sastry] GITAM, Dept Biochem, GITAM Inst Sci, Visakhapatnam, Andhra Pradesh, India.
   [Tantravahi, Srinivasan] Indira Gandhi Natl Tribal Univ, Dept Bot, Amarkantak, India.
C3 Shiv Nadar University; Gandhi Institute of Technology & Management
   (GITAM); Guru Ghasidas Vishwavidyalaya; Department of Biotechnology
   (DBT) India; Gandhi Institute of Technology & Management (GITAM); Indira
   Gandhi National Tribal University
RP Tantravahi, S (corresponding author), Indira Gandhi Natl Tribal Univ, Dept Bot, Amarkantak, India.
EM saveplants@gmail.com
RI ; Tiwari, Anand Krishna/HPG-2359-2023
OI BHANU PRAKASH, GOLLAPALLI VENKATA SUBRAHMANYA/0000-0002-4415-7865;
   Mupparthi, Sri Durgambica/0000-0002-9170-0445; Tantravahi,
   Srinivasan/0000-0002-8400-154X; SHUKLA, DHANANAJAY/0000-0001-9468-9897
FU DST-FIST
FX We thank Dr. K.R. Rajesh Kumar for his views and suggestions. We also
   acknowledge the DST-FIST support to the Department of Botany, Indira
   Gandhi National Tribal University, Amarkantak, India.
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NR 121
TC 67
Z9 77
U1 4
U2 90
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PY 2020
VL 21
IS 7
BP 512
EP 524
DI 10.2174/1389200221666200610172105
PG 13
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA OP5ZS
UT WOS:000588165200004
PM 32520682
DA 2026-05-27
ER

PT J
AU Liu, SS
   Li, YY
   Li, ZX
AF Liu, Shaosheng
   Li, Yuanyuan
   Li, Zhaoxia
TI Salidroside suppresses the activation of nasopharyngeal carcinoma cells
   via targeting miR-4262/GRP78 axis
SO CELL CYCLE
LA English
DT Article
DE Nasopharyngeal carcinoma; Salidroside; miR-4262; GRP78
ID CANCER CELLS; PROLIFERATION; INVASION
AB To study the effect of Salidroside on nasopharyngeal carcinoma (NPC) cells and its mechanism. NPC cells were cultured, MTT was used to detect the effect of Salidroside on cell proliferation, apoptosis detected by flow cytometry assay, Western blot was used to detect the related protein expression. MiR-4262 and GRP78 used qRT-PCR for evaluation. Mimics/mimic NC and miR-4262 inhibitor/inhibitor NC were transfected into CNE2 and HONE1 cell lines, and cell viability was detected by MTT. Caspase-3, -8 and -9 activities were detected by caspase colorimetric assay kit. Targetscan predicted that downstream target of miR-4262. Relative luciferase activity was detected by luciferase assay. The effect of Salidroside on the growth of transplanted tumor in nude mice was observed. After Salidroside treatment, cell proliferation decreased and apoptosis increased, Bax protein expression increased and Bcl-2 decreased; miR-4262 expression level in nasopharyngeal carcinoma tissues was lower than that in adjacent tissues. GRP78 was the target of miR-4262 and downregulate the expression of miR-4262 in NPC cells can increase the expression of GRP78, and the expression of GRP78 decreased after upregulating the expression of miR-4262. Salidroside could inhibit the growth of NPC xenografts in nude mice. The level of Bax was increased and Bcl-2 was decreased in Salidroside group. Salidroside can significantly inhibit the proliferation and promote the apoptosis of NPC cells via regulating miR-4262/GRP78 signal axis.
C1 [Liu, Shaosheng] Zhejiang Univ, Peoples Hosp Beilun, Dept Otorhinolaryngol, Beilun Branch,Hosp 1, Ningbo, Peoples R China.
   [Li, Yuanyuan] 988 Hosp Joint Logist Support Force Chinese Peopl, Dept Med & Equipment, Hena, Peoples R China.
   [Li, Zhaoxia] Jinan Cent Hosp, Dept Otolaryngol, 105 Jiefang Rd, Jinan, Shangdong, Peoples R China.
C3 Zhejiang University; Shandong First Medical University & Shandong
   Academy of Medical Sciences
RP Li, ZX (corresponding author), Jinan Cent Hosp, Dept Otolaryngol, 105 Jiefang Rd, Jinan, Shangdong, Peoples R China.
EM lzx1396403@163.com
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NR 35
TC 17
Z9 24
U1 0
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1538-4101
EI 1551-4005
J9 CELL CYCLE
JI Cell Cycle
PD APR 3
PY 2022
VL 21
IS 7
BP 720
EP 729
DI 10.1080/15384101.2021.2019976
EA FEB 2022
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0E5HT
UT WOS:000761503300001
PM 35220889
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Wang, Y
   Su, Y
   Lai, W
   Huang, X
   Chu, K
   Brown, J
   Hong, G
AF Wang, Y.
   Su, Y.
   Lai, W.
   Huang, X.
   Chu, K.
   Brown, J.
   Hong, G.
TI Salidroside Restores an Anti-inflammatory Endothelial Phenotype by
   Selectively Inhibiting Endothelial Complement After Oxidative Stress
SO INFLAMMATION
LA English
DT Article
DE complement; endothelial cells; inflammation; salidroside; stroke
ID FOCAL CEREBRAL-ISCHEMIA; NF-KAPPA-B; ADHESION MOLECULES;
   GENE-EXPRESSION; MESSENGER-RNAS; COMPONENT C3; CELLS; REOXYGENATION;
   ACTIVATION; ICAM-1
AB Abstract Salidroside, an active component of Rhodiola rosea, reduces inflammation and neuronal damage after middle cerebral artery occlusion (MCAO) with reperfusion, partly by inhibiting cerebral complement C3 activation. However, the mechanisms of this inhibition are not fully understood. In this study, we investigated which cerebral cells might contribute to the inhibition of complement by salidroside and the consequences of this inhibition. We used human umbilical endothelial cells (HUVEC) as a model of cerebral endothelium and found that salidroside prevented the increases of C3 and its active fragment C3a, and the associated increases in C1q and C2, otherwise caused by oxygen-glucose deprivation followed by restoration (OGD/R). However, salidroside did not affect C1q, C2 or C3 in astrocytes and microglial BV2 cells after OGD/R. Salidroside also prevented the decreases in CD46 and CD59, and the increases in VCAM-1, ICAM-1, P-selectin and E-selectin caused by OGD/R in HUVEC, which were associated with decreasing LDH release and increasing Bcl-2/Bax ratio. None of these effects of salidroside occurred in the absence of oxygen-glucose restoration. Moreover, salidroside and C3a receptor antagonist reduced the markers of endothelial activation and neutrophil adhesion to HUVEC after OGD/R to similar extents, and their effects were not additive. Correspondingly, salidroside reduced the markers of endothelial activation and neutrophilic infiltration in the rat brains after MCAO with reperfusion. These results suggest endothelium is an important locus of inhibition of complement by salidroside, restoring an anti-inflammatory endothelial phenotype after oxidative stress, partly by inhibiting classical complement activation and partly by increasing CD46 and CD59, in association with anti-apoptotic effects. These endothelial effects may contribute to the protection afforded by salidroside in cerebral ischemia-reperfusion injury.
C1 [Wang, Y.; Lai, W.; Huang, X.; Chu, K.; Brown, J.; Hong, G.] Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Peoples R China.
   [Su, Y.] Fujian Univ Tradit Chinese Med, Peoples Hosp, 602 BayiqiZhong Rd, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine
RP Hong, G (corresponding author), Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Peoples R China.
EM guizhuhong@fjtcm.edu.cn
OI Hong, Guizhu/0000-0003-3932-4777
FU National Natural Science Foundation of China [81473382] Funding Source:
   Medline; Young Scientists Fund [81603323] Funding Source: Medline
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NR 49
TC 37
Z9 42
U1 2
U2 26
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD FEB
PY 2020
VL 43
IS 1
BP 310
EP 325
DI 10.1007/s10753-019-01121-y
PG 16
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA KR8EZ
UT WOS:000517850100030
PM 31701353
DA 2026-05-27
ER

PT J
AU Lin, SY
   Xu, D
   Du, XX
   Ran, CL
   Xu, L
   Ren, SJ
   Tang, ZT
   Yin, LZ
   He, CL
   Yuan, ZX
   Fu, HL
   Zhao, XL
   Shu, G
AF Lin, Shi-Yu
   Xu, Dan
   Du, Xia-Xia
   Ran, Chong-Lin
   Xu, Lu
   Ren, Shao-Jun
   Tang, Zi-Ting
   Yin, Li-Zi
   He, Chang-Liang
   Yuan, Zhi-Xiang
   Fu, Hua-Lin
   Zhao, Xiao-Ling
   Shu, Gang
TI Protective Effects of Salidroside against Carbon Tetrachloride
   (CCl4)-Induced Liver Injury by Initiating Mitochondria to
   Resist Oxidative Stress in Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Salidroside; CCl4; liver injury; mitochondria; oxidative stress
ID DIAMMONIUM GLYCYRRHIZINATE; RAT-LIVER; APOPTOSIS; AUTOPHAGY; CELLS;
   ACTIVATION; TOXICITY; DAMAGE
AB The antioxidant effect of salidroside has been proven, but its role in liver injury is poorly understood. In this study, we aimed to evaluate the protective effects and mechanism of salidroside on liver injury induced by carbon tetrachloride (CCl4) in vivo. Mice were pretreated with salidroside (60 mg/kg, intraperitoneally injected, i.p.) once per day for 14 consecutive days and then administered with CCl4 (15.95 g/kg, i.p.) for 24 h to produce a liver injury model. Salidroside attenuated hepatic transaminase elevation in serum and ameliorated liver steatosis and necrosis, thereby suggesting its protective effect on the liver. Salidroside antagonized CCl4-induced toxicity by equilibrating antioxidation system, thereby inhibiting reactive oxygen species accumulation, and restoring mitochondrial structure and function. Salidroside exerts antioxidant and liver-protective effects by selectively inhibiting the activation of genes, including growth arrest and DNA -damage-inducible 45 alpha (Gadd45a), mitogen-activated protein kinase 7 (Mapk7), and related RAS viral oncogene homolog 2 (Rras2), which induce oxidative stress in the mitogen-activated protein kinase pathway. These results revealed that salidroside can protect the liver from CCl4-induced injury by resisting oxidative stress and protecting mitochondrial function.
C1 [Lin, Shi-Yu; Xu, Dan; Du, Xia-Xia; Ran, Chong-Lin; Xu, Lu; Ren, Shao-Jun; Tang, Zi-Ting; Yin, Li-Zi; He, Chang-Liang; Yuan, Zhi-Xiang; Fu, Hua-Lin; Shu, Gang] Sichuan Agr Univ, Vet Med Coll, Dept Pharm, Chengdu 611130, Sichuan, Peoples R China.
   [Zhao, Xiao-Ling] Sichuan Agr Univ, Coll Anim Sci & Technol, Dept Anim Sci, Chengdu 611130, Sichuan, Peoples R China.
C3 Sichuan Agricultural University; Sichuan Agricultural University
RP Shu, G (corresponding author), Sichuan Agr Univ, Vet Med Coll, Dept Pharm, Chengdu 611130, Sichuan, Peoples R China.
EM dyysg2005@sicau.edu.cn
RI ; yuan, zhi-xiang/AAE-3862-2020; Du, Xiaxia/GXN-2129-2022
OI ziting, Tang/0000-0003-1589-8928; yuan, zhi-xiang/0000-0001-7809-2580; 
FU National Foundation of Natural Science of China [31872347]
FX This work was supported by grants from the National Foundation of
   Natural Science of China (31872347).
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NR 47
TC 51
Z9 60
U1 3
U2 63
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3187
DI 10.3390/ijms20133187
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100075
PM 31261843
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, LX
   Mo, QL
   Wu, YN
   Chen, WC
   Deng, KX
   Xiao, Y
AF Chen, Lixuan
   Mo, Qinglin
   Wu, Yingnan
   Chen, Wancheng
   Deng, Kaixian
   Xiao, Yang
TI Ameliorative effect of salidroside on the cyclophosphamide-induced
   premature ovarian failure in a rat model
SO FREE RADICAL RESEARCH
LA English
DT Article
DE salidroside; premature ovarian failure (POF); oxidative stress injury;
   antioxidant activity; Nrf2 signaling
ID HORMONE REPLACEMENT THERAPY; TRANSCRIPTION FACTOR NRF2; OXIDATIVE
   STRESS; YOUNG-WOMEN; RHODIOLA; DAMAGE; INSUFFICIENCY; MECHANISMS;
   MANAGEMENT; CELLS
AB BackgroundOxidative stress injury is an important pathological factor of premature ovarian failure (POF). Salidroside, extracted from the Chinese herb-Rhodiola rosea, has advantages in antioxidant characteristics. However, their therapeutic efficacy and mechanisms in POF have not been explored.PurposeThis study aims to assess the therapeutic effects of salidroside in chemotherapy-induced ovarian failure rats.MethodsA POF rat model was established by injection of cyclophosphamide, followed by treatment with salidroside. The therapeutic effect of salidroside was evaluated based on hormone levels, follicle count, and reproductive ability. Oxidative stress injury was assessed by the detection of SOD enzyme activity and MDA levels. Differential gene expression of Keap1, Nrf2, HMOX1, NQO1, AMH, BMP15, and GDF9, were identified by qRT-PCR. The protein expression of Keap1, Nrf2, P53, and Bcl-2 were detected by western blot.ResultsSalidroside treatment markedly restored FSH, E2, and AMH hormone secretion levels, reduced follicular atresia, and increased antral follicle numbers in POF rats. In addition, salidroside improves fertility in POF rats, activates the Nrf2 signaling pathway, and reduces the level of oxidative stress. The recovery function of high dose salidroside (50 mg/kg) in a reproductive assay was significantly improved than that of lower dose salidroside (25 mg/kg). Meanwhile, the safety evaluation of salidroside treatment in rats showed that salidroside was safe for POF rats at doses of 25-50 mg/kg.ConclusionsSalidroside therapy improved premature ovarian failure significantly through antioxidant function and activating Nrf2 signaling.
C1 [Chen, Lixuan; Xiao, Yang] Guangzhou Univ chinese Med, Guangzhou, Peoples R China.
   [Chen, Lixuan] Guangzhou Univ Chinese Med, Jinshazhou Hosp, Guangzhou, Peoples R China.
   [Mo, Qinglin; Wu, Yingnan] Guangzhou Med Univ, Translat Med Ctr, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Chen, Wancheng] Southern Med Univ, Zhujiang Hosp, Dept Radiotherapy & Oncol, Guangzhou, Peoples R China.
   [Deng, Kaixian] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Dept Gynecol, Foshan, Peoples R China.
   [Xiao, Yang] Shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, Shenzhen, Peoples R China.
   [Xiao, Yang] shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, 36 shekou Ind seventh Rd,Nanshan Dist, Shenzhen 518101, Guangdong, Peoples R China.
   [Deng, Kaixian] shunde Hosp southern Med Univ, Peoples Hosp shunde 1, Dept Gynecol, 1 Jiazi Rd,li Village,lunjiao St, Foshan 528399, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou Medical University; Southern Medical
   University - China; Southern Medical University - China
RP Xiao, Y (corresponding author), shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, 36 shekou Ind seventh Rd,Nanshan Dist, Shenzhen 518101, Guangdong, Peoples R China.; Deng, KX (corresponding author), shunde Hosp southern Med Univ, Peoples Hosp shunde 1, Dept Gynecol, 1 Jiazi Rd,li Village,lunjiao St, Foshan 528399, Guangdong, Peoples R China.
RI wu, yingnan/AAB-2580-2020
FU Foshan Municipal Science and Technology Bureau 2020 Foshan Municipal
   Science and Technology Research Project [2020001006077]; Special Funding
   Fund for Clinical Scientific Research of Wu Jieping Medical Foundation
   [320.6750.2021-04-43]; Regional Joint Fund of Basic and Applied Basic
   Research Fund of Guangdong Province [2019B151520082]
FX This research was supported by the Foshan Municipal Science and
   Technology Bureau 2020 Foshan Municipal Science and Technology Research
   Project (Grant No. 2020001006077), Special Funding Fund for Clinical
   Scientific Research of Wu Jieping Medical Foundation (Grant No.
   320.6750.2021-04-43), and the Regional Joint Fund of Basic and Applied
   Basic Research Fund of Guangdong Province (Grant No. 2019B151520082).
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NR 42
TC 9
Z9 13
U1 7
U2 31
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD FEB 1
PY 2024
VL 58
IS 2
BP 107
EP 116
DI 10.1080/10715762.2024.2320383
EA MAR 2024
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA MS5S3
UT WOS:001181131000001
PM 38408280
DA 2026-05-27
ER

PT J
AU Li, QY
   Wang, JH
   Li, YW
   Xu, XL
AF Li, Qingyun
   Wang, Jinhua
   Li, Yuwang
   Xu, Xiaolin
TI Neuroprotective effects of salidroside administration in a mouse model
   of Alzheimer's disease
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE APPswe/PS1 Delta E9 mouse; salidroside; SOD; MDA; GSH; nitrate;
   TNF-alpha; IL-10
ID RAT MODEL; IN-VITRO; EXPRESSION; INJURY; MEMORY; MICE
AB Salidroside administration improves memory in different models of learning. However, its influence on models of Alzheimer's disease (AD) has not been widely studied. In the present study, the therapeutic effect of salidroside was investigated in an animal model of AD. APPswe/PS1E9 mouse (n=20) were randomly divided into either the AD model group or the salidroside + AD model group (n=10 in each group), and C57BL/6J mouse (n=20) of identical age and genetic background were randomly divided into either the normal control (NC) group or the salidroside + NC group (n=10 in each group). The Morris water maze behavioral test was applied to all mice in order to investigate the effects of salidroside administration on learning and memory functions. The concentrations of malondialdehyde (MDA), glutathione (GSH) and nitrate in the hippocampus of the mice were determined, and hippocampal superoxide dismutase (SOD) activity was also determined. In addition, terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling was used to investigate the rate of neuronal apoptosis in the hippocampus. Furthermore, the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha(TNF-alpha) were tested for in the brain tissues of AD mice. Learning and memory functions in AD mice were revealed to improve following administration of salidroside. Furthermore, salidroside administration was revealed to decrease the concentrations of MDA and nitrate in the hippocampus, decrease the apoptotic rate of hippocampal neurons, and increase the activity of SOD and the concentration of GSH in hippocampal tissue. In addition, it was demonstrated that salidroside administration suppressed the expression levels of IL-6 and TNF-alpha In conclusion, this study revealed that the administration of salidroside could attenuate the effects of AD-associated memory and learning impairment in mice. Furthermore, it was demonstrated that the effects of salidroside administration on AD mice were, at least partially, via inhibition of brain oxidative/nitrosative damage, suppression of both IL-6 and TNF-alpha expression levels, and suppression of the hippocampal neuronal apoptotic rate.
C1 [Li, Qingyun; Li, Yuwang; Xu, Xiaolin] Tianjin Huanhu Hosp, Dept Neurol, 6 Jizhao Rd, Tianjin 300350, Peoples R China.
   [Wang, Jinhua] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Neurol, Taizhou 318000, Zhejiang, Peoples R China.
C3 Taizhou University
RP Xu, XL (corresponding author), Tianjin Huanhu Hosp, Dept Neurol, 6 Jizhao Rd, Tianjin 300350, Peoples R China.
EM xuxltj@163.com
RI Li, QingYun/KLY-9523-2024
FU Natural Science Foundation of Tianjin Municipal Science and Technology
   Commission [13JCYBJC22700]
FX The present study was supported by a grant from Natural Science
   Foundation of Tianjin Municipal Science and Technology Commission (grant
   no. 13JCYBJC22700).
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NR 33
TC 31
Z9 38
U1 0
U2 38
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY
PY 2018
VL 17
IS 5
BP 7287
EP 7292
DI 10.3892/mmr.2018.8757
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GD5OR
UT WOS:000430556800134
PM 29568861
OA Bronze
DA 2026-05-27
ER

PT J
AU Qi, ZL
   Tang, T
   Sheng, LL
   Ma, YF
   Liu, YH
   Yan, L
   Qi, SM
   Ling, LF
   Zhang, Y
AF Qi, Zhilin
   Tang, Tuo
   Sheng, Lili
   Ma, Yunfei
   Liu, Yinhua
   Yan, Liang
   Qi, Shimei
   Ling, Liefeng
   Zhang, Yao
TI Salidroside inhibits the proliferation and migration of gastric cancer
   cells via suppression of Src-associated signaling pathway activation and
   heat shock protein 70 expression
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; cell migration; reactive oxygen species; heat shock protein
   70; epithelial-mesenchymal transition
ID TO-MESENCHYMAL TRANSITION; PERITONEAL MESOTHELIAL CELLS; HUMAN
   BREAST-CANCER; INVASION; GROWTH; EPIDEMIOLOGY; PROGRESSION; PRODUCTS;
   ROS
AB Salidroside, an active ingredient extracted from the Rhodiola rosea plant, has potential anti-tumor effects. However, the effects of salidroside on gastric cancer cell proliferation and migration remain unclear. In the present study, the inhibitory effects of salidroside on gastric cancer cell proliferation, migration and invasion and the molecular mechanisms underlying these effects were investigated. The human gastric cancer cell line, BGC-823, was treated with different concentrations of salidroside (200, 400 and 600 mu g/ml). Cell proliferation was determined with Cell Counting Kit-8 and colony formation assays, and the migration and invasion of cells was detected by a wound healing and Transwell assay, respectively. Western blotting was performed to detect the levels of N-cadherin, E-cadherin and heat shock protein (HSP)70. In addition, the phosphorylation of proto-oncogene tyrosine-protein kinase Src (Src), protein kinase B (Akt), mitogen activated protein kinase 1 (ERK), signal transducer and activator of transcription (STAT)3 and focal adhesion kinase 1 (FAK) was examined by western blotting. The levels of matrix metalloproteinase (MMP)-2 and MMP-9 were determined by enzyme-linked immunosorbent assay kits. Levels of reactive oxygen species (ROS) in cells were measured by a fluorescence plate reader with dichloro-dihydro-fluorescein diacetate. The results indicated that salidroside significantly suppressed cell proliferation and colony formation, inhibited cell migration and invasion, increased E-cadherin expression and decreased N-cadherin, MMP-2 and MMP-9 expression. Furthermore, salidroside suppressed ROS production and subsequently reduced the phosphorylation of Src, Akt, ERK and FAK. Salidroside also inhibited HSP70 expression, and HSP70 overexpression reversed the inhibitory effects of salidroside on BGC-823 cell proliferation, migration and invasion. In conclusion, the present study revealed that salidroside inhibited the proliferation, migration and invasion of BGC-823 cells by downregulating ROS-mediated Src-associated signaling pathway activation and HSP70 expression.
C1 [Qi, Zhilin; Yan, Liang; Qi, Shimei; Ling, Liefeng; Zhang, Yao] Wannan Med Coll, Dept Biochem, 22 Wenchang West Rd, Wuhu 241002, Anhui, Peoples R China.
   [Qi, Zhilin; Tang, Tuo; Ma, Yunfei; Yan, Liang; Qi, Shimei; Ling, Liefeng; Zhang, Yao] Wannan Med Coll, Anhui Prov Key Lab Act Biol Macromol, Wuhu 241002, Anhui, Peoples R China.
   [Sheng, Lili] Wannan Med Coll, Yijishan Hosp, Dept Oncol, Wuhu 241002, Anhui, Peoples R China.
   [Liu, Yinhua] Wannan Med Coll, Yijishan Hosp, Dept Pathol, Wuhu 241002, Anhui, Peoples R China.
C3 Wannan Medical College; Wannan Medical College; Wannan Medical College;
   Wannan Medical College
RP Qi, ZL; Zhang, Y (corresponding author), Wannan Med Coll, Dept Biochem, 22 Wenchang West Rd, Wuhu 241002, Anhui, Peoples R China.
EM 422627721@qq.com; zhangyao@ahedu.gov.cn
RI Ma, Yunfei/IUO-7073-2023
OI Ma, Yunfei/0000-0002-4448-9472
FU National Nature Science Foundation of China [81601380]; Natural Science
   Research Project of Anhui Colleges and Universities [KJ2016SD59];
   Outstanding Young Talent Support Program Key Projects in Anhui Colleges
   and Universities [gxyqZD2016173]; Anhui Province Key Laboratory of
   Active Biological Macromolecules [1306C083008]
FX This study was supported by the National Nature Science Foundation of
   China (grant no. 81601380), Natural Science Research Project of Anhui
   Colleges and Universities (grant no. KJ2016SD59), Outstanding Young
   Talent Support Program Key Projects in Anhui Colleges and Universities
   (grant no. gxyqZD2016173) and Anhui Province Key Laboratory of Active
   Biological Macromolecules (grant no. 1306C083008).
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NR 39
TC 36
Z9 44
U1 0
U2 22
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2018
VL 18
IS 1
BP 147
EP 156
DI 10.3892/mmr.2018.8958
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GP1OB
UT WOS:000440584500017
PM 29749547
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Chang, XY
   Zhang, K
   Zhou, R
   Luo, F
   Zhu, LP
   Gao, J
   He, H
   Wei, TT
   Yan, TH
   Ma, CH
AF Chang, Xiayun
   Zhang, Kai
   Zhou, Rui
   Luo, Fen
   Zhu, Lingpeng
   Gao, Jin
   He, He
   Wei, Tingting
   Yan, Tianhua
   Ma, Chunhua
TI Cardioprotective effects of salidroside on myocardial
   ischemia-reperfusion injury in coronary artery occlusion-induced rats
   and Langendorff-perfused rat hearts
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Salidroside; Myocardial ischemia-reperfusion; Energy metabolism;
   Inflammation; AMPK/PGC-1 alpha; AMPK/NF-kappa B
ID SUBSTRATE METABOLISM; IN-VIVO; AMPK; PGC-1-ALPHA; PROTECTS; PATHWAY;
   MODEL; ATP
AB Background/objectives: The current study was designed to investigate the protective role of salisroside on rats through the study of energy metabolism homeostasis and inflammation both in ex vivo and in vivo.
   Methods: Energy metabolism homeostasis and inflammation injury were respectively assessed in global ischemia of isolated hearts and coronary artery ligated rats.
   Results: Excessive release of cardiac enzymes and pro-inflammatory cytokines was inhibited by salidroside in coronary artery occlusion-induced rats. ST segment was also restored with the treatment of salidroside. Triphenyl-tetrazolium chloride staining (TTC) staining and pathological analysis showed that salidroside could significantly alleviate myocardial injury in vivo. Accumulated data in ex vivo indicated that salidroside improved heart function recovery, which was reflected by enhanced myocardial contractility and coronary flow in isolated hearts. The contents of ATP and glycogen both in ex vivo and in vivo were restored by salidroside compared with those in the model group. Besides, the expressions of p-AMPK, PPAR-alpha and PGC-1 alpha in rats and isolated hearts subjected to salidroside were significantly elevated, while the levels of p-NF-kappa Bp65, p-I kappa Ba, p-IKK alpha and p-IKK beta were dramatically reduced by salidroside.
   Conclusions: The present study comprehensively elaborated the protective effects of salidroside on myocardial injury and demonstrated that AMPK/PGC-1 alpha and AMPK/NF-kappa B signaling cascades were implicated in the myocardial ischemia-reperfusion injury (I/R) model. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Chang, Xiayun; Zhou, Rui; Luo, Fen; Zhu, Lingpeng; Gao, Jin; He, He; Wei, Tingting; Yan, Tianhua; Ma, Chunhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhang, Kai] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Yan, TH; Ma, CH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
EM yantianhuabest@126.com
RI zhou, rui/KZT-9353-2024; Su, Tianyuan/Y-7054-2019; he, he/JPL-3505-2023
FU National Twelve Five Major Drug Discovery project [2011ZX09102-002-01]
FX This work was supported by National Twelve Five Major Drug Discovery
   project (2011ZX09102-002-01).
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NR 40
TC 66
Z9 78
U1 0
U2 45
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 15
PY 2016
VL 215
BP 532
EP 544
DI 10.1016/j.ijcard.2016.04.108
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DM4DX
UT WOS:000376297100116
PM 27155549
DA 2026-05-27
ER

PT J
AU Liu, Y
   Li, HX
AF Liu, Yuan
   Li, Huixia
TI Salidroside improves hypoxia-induced milk synthesis disorder and
   endoplasmic reticulum stress via AKT/mTOR signaling in bovine mammary
   epithelial cells
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Hypoxia; Salidroside; Milk protein and fat; ER stress; AKT/mTOR pathway;
   MAC-T cells
ID ER-STRESS; APOPTOSIS; EXPRESSION; RESPONSES; INJURY
AB Ethnopharmacological relevance: Rhodiola crenulata, a distinctive medicinal herb in Tibetan medicine, has been utilized for thousands of years to treat physical weakness, chest tightness, difficulty breathing, and discomfort caused by high-altitude environments. Salidroside is one of the most potent bioactive ingredients of the genus Rhodiola. Aim of study: This study investigated the protective effect of salidroside in hypoxia-induced milk biosynthesis impairment using bovine mammary epithelial cells (MAC-T), elucidating its underlying molecular mechanism. Materials and methods: Cells with or without salidroside were exposed to hypoxia, with milk biosynthesis quantitatively assessed via using immunofluorescence, biochemical assays, Western blot, and Quantitative realtime PCR (QRT-PCR), alongside parallel evaluation of endoplasmic reticulum (ER) and mitochondrial functions. Results: Results demonstrated that hypoxia inhibited cell proliferation, downregulated mRNA/protein expression of milk synthesis factors (alpha-casein, beta-casein, SREBP1, and FASN), and concurrently triggered ER stress and mitochondrial dysfunction. Conversely, salidroside alleviated hypoxia-induced milk biosynthesis disorder through inhibiting ER stress. Additionally, hypoxia treatment decreased the expression of phosphorylated protein kinase B (AKT) and mammalian target of rapamycin (mTOR) levels, whereas salidroside blocked the decrease in p-AKT and p-mTOR levels. Targeted activation of AKT/mTOR signaling using SC79 (an AKT activator) or Lleucine (a mTOR activator) mimicked salidroside's protective effects, rescuing ER homeostasis, and milk synthesis capacity in hypoxia-treated cells. Conclusions: The AKT/mTOR signaling is involved in the protective effect of salidroside on hypoxia-induced milk biosynthesis disorder. These findings provide promising evidence for the therapeutic potential of salidroside against hypoxia-induced cellular damage and milk biosynthesis impairment in MAC-T cells.
C1 [Liu, Yuan; Li, Huixia] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing, Peoples R China.
C3 Nanjing Agricultural University
RP Li, HX (corresponding author), Nanjing Agr Univ, Nanjing 210095, Peoples R China.
EM lihuixia@njau.edu.cn
FU National Natural Science Foundation of China [32172725]
FX This work was supported by the National Natural Science Foundation of
   China (No. 32172725) .
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NR 58
TC 0
Z9 0
U1 7
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 30
PY 2026
VL 355
AR 120659
DI 10.1016/j.jep.2025.120659
EA OCT 2025
PN B
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 8UE0Z
UT WOS:001597417800003
PM 41016539
DA 2026-05-27
ER

PT J
AU Hu, R
   Wang, MQ
   Ni, SH
   Wang, M
   Liu, LY
   You, HY
   Wu, XH
   Wang, YJ
   Lu, L
   Wei, LB
AF Hu, Rong
   Wang, Ming-qing
   Ni, Shi-hao
   Wang, Ming
   Liu, Ling-yu
   You, Hai-yan
   Wu, Xiao-hui
   Wang, Yan-jing
   Lu, Lu
   Wei, Lian-bo
TI Salidroside ameliorates endothelial inflammation and oxidative stress by
   regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; AGEs; Endothelial inflammation; Oxidative stress; HUVECs
ID NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; DIABETIC-NEPHROPATHY; NLRP3
   INFLAMMASOME; HIGH GLUCOSE; TNF-ALPHA; DYSFUNCTION; EXPRESSION; CELLS;
   MECHANISMS
AB Endothelial dysfunction plays important roles in vascular dysfunction under diabetic conditions. The generation of advanced glycation end products (AGEs), which can induce inflammation and oxidative stress, is pivotal in endothelial dysfunction. Salidroside, a major active compound in Rhodiola rosea, exerts protective effects against vascular diseases. To study the effects and mechanism of salidroside in diabetes-induced vascular endothelial dysfunction, an in vitro model was established with AGEs-induced human umbilical vein endothelial cells (HUVECs). Then, cell viability, cell apoptosis, pro-inflammatory cytokines and oxidative biomarkers were tested to determine the effects of salidroside at 10, 50 and 100 mu M doses on AGEs induced HUVECs. Additionally, RNASeq and bioinformatics analyses were used to search for the underlying mechanism of salidroside. The results showed that salidroside promoted cell viability and significantly alleviated cell apoptosis in AGEs-induced HUVECs. Furthermore, salidroside remarkably decreased the levels of the pro-inflammatory cytokines TNF-alpha, IL-1 beta and IL-6 and impeded the expression of VCAM-1 and ICAM-1 induced by AGEs. Additionally, salidroside promoted superoxide dismutase (SOD) activity and increased catalase (CAT) and glutathione peroxidase (GSHPx) levels while inhibiting the intracellular generation of reactive oxygen species (ROS) and malondialdehyde (MDA) in AGEs-induced HUVECs. Importantly, salidroside alleviated endothelial inflammation and oxidative stress by activating AMPK phosphorylation and inhibiting NF-kappa B p65 and NLRP3 inflammasome activation. Therefore, we used compound C, an accepted AMPK inhibitor, to further demonstrate the mechanism. Interestingly, the phenomenon produced by salidroside was abolished. Our findings suggest that salidroside ameliorates AGEs-induced endothelial inflammation and oxidative stress, partially via the AMPK/NF-kappa B/NLRP3 signaling pathway.
C1 [Hu, Rong; Wang, Ming-qing; Liu, Ling-yu; You, Hai-yan; Wu, Xiao-hui; Wei, Lian-bo] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
   [Hu, Rong; Wang, Ming-qing; Liu, Ling-yu; You, Hai-yan; Wu, Xiao-hui; Wei, Lian-bo] Southern Med Univ, Shenzhen Hosp, Shenzhen 518101, Guangdong, Peoples R China.
   [Wang, Ming; Wang, Yan-jing] Southern Med Univ, Zhujiang Hosp, Guangzhou 510280, Guangdong, Peoples R China.
   [Ni, Shi-hao; Lu, Lu] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China; Guangzhou University of
   Chinese Medicine
RP Wei, LB (corresponding author), Southern Med Univ, Shenzhen Hosp, Shenzhen 518101, Guangdong, Peoples R China.; Wang, YJ (corresponding author), Southern Med Univ, Zhujiang Hosp, Guangzhou 510280, Guangdong, Peoples R China.; Lu, L (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China.
EM 397271626@qq.com; coinland@gzucm.edu.cn; wlb@smu.edu.cn
RI ; WU, XIAOHUI/NHO-8747-2025
OI Lu, Lu/0000-0002-9457-0164; 
FU National Natural Science Foundation of China [81573729, 81774094,
   81603472]; Research Project of the Guangdong Provincial Administration
   of Traditional Chinese Medicine [20171161]
FX This study was supported in part by the National Natural Science
   Foundation of China (Program No. 81573729, 81774094 and No. 81603472)
   and the Research Project of the Guangdong Provincial Administration of
   Traditional Chinese Medicine (No. 20171161).
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NR 56
TC 188
Z9 215
U1 7
U2 185
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JAN 15
PY 2020
VL 867
AR 172797
DI 10.1016/j.ejphar.2019.172797
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JX9CL
UT WOS:000504024800014
PM 31747547
DA 2026-05-27
ER

PT J
AU Ni, J
   Li, YM
   Li, WM
   Guo, R
AF Ni, Jing
   Li, Yuanmin
   Li, Weiming
   Guo, Rong
TI Salidroside protects against foam cell formation and apoptosis, possibly
   via the MAPK and AKT signaling pathways
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE THP1; Salidroside; Foam cell; Akt pathway; MAPK pathway
ID NF-KAPPA-B; OXIDATIVE STRESS; CHOLESTEROL EFFLUX; NATURAL-PRODUCTS;
   ACTIVATION; RECEPTOR; ACID; NRF2; ATHEROSCLEROSIS; ABCA1
AB Background: Foam cell formation and apoptosis are closely associated with atherosclerosis pathogenesis. We determined the effect of salidroside on oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation and apoptosis in THP1 human acute monocytic leukemia cells and investigated the associated molecular mechanisms.
   Methods: THP1-derived macrophages were incubated with salidroside for 5 h and then exposed to ox-LDL for 24 h to induce foam cell formation. Cytotoxicity, lipid deposition, apoptosis, and the expression of various proteins were tested using the CCK8 kit, Oil Red O staining, flow cytometry, and western blotting, respectively.
   Results: Ox-LDL treatment alone promoted macrophage-derived foam cell formation, while salidroside treatment alone inhibited it (p < 0.05). The number of early/late apoptotic cells decreased with salidroside treatment in a dose-dependent manner (p < 0.05). Salidroside dramatically upregulated nuclear factor erythroid 2-related factor 2, but had no effect on heme oxygenase-1 expression; moreover, it markedly downregulated ox-LDL receptor 1 and upregulated ATP-binding cassette transporter A1. Salidroside also obviously decreased the phosphorylation of JNK, ERK, p38 MAPK, and increased that of Akt. However, the total expression of these proteins was not affected.
   Conclusion: Based on our findings, we speculate that salidroside can suppress ox-LDL-induced THP1-derived foam cell formation and apoptosis, partly by regulating the MAPK and Akt signaling pathways.
C1 [Ni, Jing; Li, Weiming; Guo, Rong] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China.
   [Li, Yuanmin] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiothorac Surg, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China.
C3 Tongji University; Tongji University
RP Li, WM; Guo, R (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China.
EM lwmsoncentury@126.com; doctorguorong@aliyun.com
OI Guo, Rong/0000-0003-1323-5450
FU Science Foundation for The Excellent Youth Scholars of Tongji University
   [2016KJ052]
FX This study was supported by Science Foundation for The Excellent Youth
   Scholars of Tongji University (Grant No. 2016KJ052).
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NR 64
TC 29
Z9 37
U1 1
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD OCT 10
PY 2017
VL 16
AR 198
DI 10.1186/s12944-017-0582-7
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA FJ7BL
UT WOS:000412912100001
PM 29017559
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, Z
   Yang, SX
   Liu, W
   Ling, L
   Hu, HL
   Cao, YM
   Xiang, SY
AF Li, Zhun
   Yang, Sixia
   Liu, Wei
   Ling, Long
   Hu, Hailan
   Cao, Yanming
   Xiang, Shouyu
TI Salidroside alleviates senile osteoporosis in SAMP8 mice by inhibiting
   the ferroptosis of bone marrow stromal cells via PI3K/AKT/mTOR signaling
   pathway
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Senile osteoporosis; Ferroptosis; Salidroside; PI3K/AKT/mTOR signaling
   pathway
ID AUTOPHAGY; MODEL
AB Salidroside, one of the main active compounds extracted from Rhodiola, has shown promising potential for the treatment of osteoporosis. Our previous study demonstrated that salidroside alleviated cognitive dysfunction in senescence-accelerated mouse prone 8(SAMP8) mice. In this study, we further investigated the effect of salidroside on osteoporosis in SAMP8 mice and explored the mechanism. The results of micro-computed tomography (micro-CT) and histology showed that salidroside significantly increased trabecular bone formation and improved bone microstructure in senile osteoporotic SAMP8 mice, and upregulated the protein expression levels of phosphatidylinositol-3-kinase(PI3K), glutathione peroxidase 4(GPX4), and Runt-related transcription factor 2 (RUNX2) in the distal femur. Cell-based assays, including the Cell Counting Kit-8(CCK-8) assay, senescenceassociated (3-galactosidase (SA-(3-galactosidase) staining, alkaline phosphatase (ALP) staining, Alizarin Red staining, and lipid peroxide detection, demonstrated that salidroside significantly promoted the proliferation and osteogenic differentiation of senile osteoporotic bone marrow stromal cells (BMSCs) and decreased lipid peroxide levels. Furthermore, real-time polymerase chain reaction (RT-PCR) and Western blotting analysis showed that salidroside increased protein and gene expression levels of solute carrier family 7 member 11(SLC7A11), GPX4, and ferroptosis suppressor protein 1(FSP1). Additionally, salidroside also increased the phosphorylation of PI3K, AKT, and mTOR, an effect reversed by LY294002.In conclusion, our investigation showed that salidroside could prevent ferroptosis, promote proliferation, and enhance osteogenic differentiation in senile osteoporotic BMSCs, thereby alleviating senile osteoporosis in SAMP8 mice. The PI3K/AKT/mTOR signaling pathway might play a crucial role in this mechanism. These findings suggest that salidroside has the potential to prevent senile osteoporosis and may serve as a candidate for therapeutic development.
C1 [Li, Zhun] Southern Univ Sci & Technol, Dept Resp & Crit Care Med, Peoples Hosp Foshan 1, Sch Med,,Affiliated Foshan Hosp, Guangdong, Peoples R China.
   [Xiang, Shouyu] Shantou Univ, Xiaolan Clin Inst, Med Coll, Shantou, Peoples R China.
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   [Ling, Long; Hu, Hailan] Guangzhou Med Univ, Dept Endocrinol, Affiliated Hosp 2, Guangzhou 510260, Guangdong, Peoples R China.
   [Liu, Wei] Guilin Peoples Hosp, Dept Orthoped, Guilin 541001, Peoples R China.
   [Yang, Sixia] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.
   [Yang, Sixia] Guangdong Basic Res Ctr Excellence Integrated Trad, Guangzhou 510515, Peoples R China.
C3 Southern University of Science & Technology; Shantou University;
   Guangzhou Medical University; Southern Medical University - China
RP Xiang, SY (corresponding author), Shantou Univ, Xiaolan Clin Inst, Med Coll, Shantou, Peoples R China.; Xiang, SY (corresponding author), Xiaolan Peoples Hosp ZhongShan, Peoples Hosp ZhongShan 5, Dept Orthoped, Guangdong 52841, Peoples R China.
EM xiaver0408@126.com
RI Xiang, shouyu/JPK-3812-2023
OI Xiang, shouyu/0000-0002-6484-6449
FU Science and Technology Program of Guangzhou, China [202201010976,
   202201020197, 202201020108]; Natural Science Foundation of Guangdong
   [2022A1515010829]
FX The present study was supported by the Science and Technology Program of
   Guangzhou, China (No.202201010976,No.202201020197 and No.202201020108) ,
   the Natural Science Foundation of Guangdong (No. 2022A1515010829) .
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NR 52
TC 4
Z9 4
U1 6
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 22
PY 2025
VL 167
AR 115703
DI 10.1016/j.intimp.2025.115703
EA OCT 2025
PG 13
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 9CO7H
UT WOS:001603123500004
PM 41115354
DA 2026-05-27
ER

PT J
AU Wang, J
   Li, JZ
   Lu, AX
   Zhang, KF
   Li, BJ
AF Wang, Jun
   Li, Jian-Zhe
   Lu, Ai-Xia
   Zhang, Ke-Fen
   Li, Bao-Jiang
TI Anticancer effect of salidroside on A549 lung cancer cells through
   inhibition of oxidative stress and phospho-p38 expression
SO ONCOLOGY LETTERS
LA English
DT Article
DE epithelial-mesenchymal transition; lung cancer; apoptosis; reactive
   oxygen species; invasion; salidroside
ID CYCLE ARREST; APOPTOSIS; MITOCHONDRIA; POLYPHENOLS; INVASION
AB Oxidative stress is important in carcinogenesis and metastasis. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., shows potent antioxidant properties. The aim of the present study was to investigate the roles of salidroside in cell proliferation, the cell cycle, apoptosis, invasion and epithelial-mesenchymal transition (EMT) in A549 cells. The human alveolar adenocarcinoma cell line, A549, was incubated with various concentrations of salidroside (0, 1, 5, 10 and 20 mu g/ml) and cell proliferation was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Propidium iodide (PI) staining was used to determine the cell cycle by flow cytometry. Cell apoptosis was detected by Annexin V-fluorescein isothiocyanate and PI double-staining, and tumor invasion was detected by Boyden chamber invasion assay. Western blot analysis was performed to detect the expression of EMT markers, Snail and phospho-p38. The results showed that salidroside significantly reduced the proliferation of A549 cells, inhibited cell cycle arrest in the G0/G1 phase and induced apoptosis. Salidroside inhibited transforming growth factor-beta-induced tumor invasion and suppressed the protein expression of Snail. As an antioxidant, salidroside inhibited the intracellular reactive oxygen species (ROS) formation in a dose-dependent manner in A549 cells, and depletion of intracellular ROS by vitamin C suppressed apoptosis by salidroside treatment. Salidroside was also found to inhibit the expression of phospho-p38 in A549 cells. In conclusion, salidroside inhibits cell proliferation, the cell cycle and metastasis and induces apoptosis, which may be due to its interference in the intracellular ROS generation, thereby, downregulating the ROS-phospho-p38 signaling pathway.
C1 [Wang, Jun; Li, Jian-Zhe; Lu, Ai-Xia] Cent Hosp Taian, Dept Oncol, Tai An 271000, Shandong, Peoples R China.
   [Zhang, Ke-Fen] Taishan Sanat, Dept Med Lab, Tai An 271000, Shandong, Peoples R China.
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RP Li, JZ (corresponding author), Cent Hosp Taian, Dept Oncol, 29 Longtan Rd, Tai An 271000, Shandong, Peoples R China.
EM lijzsd@126.com
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NR 31
TC 122
Z9 131
U1 1
U2 40
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD APR
PY 2014
VL 7
IS 4
BP 1159
EP 1164
DI 10.3892/ol.2014.1863
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AE9FT
UT WOS:000334311900043
PM 24944685
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, N
   Huang, F
   Jian, CD
   Qin, LN
   Lu, F
   Wang, YM
   Zhang, Z
   Zhang, Q
AF Xu, Ning
   Huang, Fang
   Jian, Chongdong
   Qin, Lina
   Lu, Fang
   Wang, Yimei
   Zhang, Zhao
   Zhang, Qian
TI Neuroprotective effect of salidroside against central nervous system
   inflammation-induced cognitive deficits: A pivotal role of sirtuin
   1-dependent Nrf-2/HO-1/NF-κB pathway
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE CNS inflammation; cognitive impairment; salidroside; SIRT1
ID ALZHEIMERS-DISEASE; PROTECTS; ACTIVATION; SENESCENCE; APOPTOSIS; STRESS;
   DAMAGE; CELLS; MODEL
AB Central nervous system (CNS) inflammation occurs in cognitive dysfunctions, but the underlying mechanisms remain unclear. Here, we investigated the role of sirtuin 1 (SIRT1) and salidroside in CNS inflammation-induced cognitive deficits model. In vivo, CNS inflammation was initiated by a single intracerebroventricular injection of lipopolysaccharide (LPS). The levels of inflammatory cytokines and the capability of free radial scavenging were determined after the LPS challenge. In vivo, salidroside and nicotinamide, a SIRT1 inhibitor, were used in PC12 cell. Of note, with the treatment of salidroside, LPS-induced learning and memory impairments were effectively improved. Salidroside also remarkably inhibited the inflammatory cytokines, up-regulated the concentration of superoxide dismutase and inhibited the vitalities of malondialdehyde in serum, hippocampus, and cell supernatant. Besides, the expression of Sirt1, Nrf-2, HO-1, Bax, Bcl-2, caspase-9, and caspase-3 and the phosphorylation of AMPK, NF-kappa Bp65, and I kappa B alpha were increased accompanying with the LPS-induced cognitive impairments, which were significantly suppressed by salidroside treatment. In PC12 cell model, nicotinamide significantly abrogated the beneficial effects of salidroside, as indicated by the antioxidant, anti-inflammatory, and antiapoptosis signaling. Together, our results showed that salidroside may be a novel therapy drug in neurodegenerative diseases, and the protective effect was involved in SIRT1-dependent Nrf-2/HO-1/NF-kappa B pathway.
C1 [Xu, Ning; Huang, Fang; Qin, Lina; Lu, Fang; Wang, Yimei; Zhang, Zhao; Zhang, Qian] Guangxi Med Univ, Affiliated Hosp 5, Dept Neurol, Nanning 530022, Guangxi, Peoples R China.
   [Xu, Ning; Huang, Fang; Qin, Lina; Lu, Fang; Wang, Yimei; Zhang, Zhao; Zhang, Qian] First Peoples Hosp Nanning, Nanning 530022, Guangxi, Peoples R China.
   [Jian, Chongdong] Affiliated Hosp Youjiang Med Nationalities, Dept Neurol, Baise, Peoples R China.
C3 Guangxi Medical University
RP Zhang, Z; Zhang, Q (corresponding author), Guangxi Med Univ, Affiliated Hosp 5, Dept Neurol, Nanning 530022, Guangxi, Peoples R China.; Zhang, Z; Zhang, Q (corresponding author), First Peoples Hosp Nanning, Nanning 530022, Guangxi, Peoples R China.
EM z1_zhang@126.com; zhangqian3339@yeah.net
FU National Natural Science Foundation of China [81860244]; Natural Science
   Foundation of Guangxi [2018GXNSFAA281051]; Basic Ability Enhancement
   Program for Young and Middleage Teachers of Guangxi [2017KY0516];
   Project of Nanning Scientific Research and Technology Development Plan
   [20163142]
FX National Natural Science Foundation of China, Grant/Award Number:
   81860244; Natural Science Foundation of Guangxi, Grant/Award Number:
   2018GXNSFAA281051; Basic Ability Enhancement Program for Young and
   Middleage Teachers of Guangxi, Grant/Award Number: 2017KY0516; Project
   of Nanning Scientific Research and Technology Development Plan,
   Grant/Award Number: 20163142
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NR 28
TC 43
Z9 49
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAY
PY 2019
VL 33
IS 5
BP 1438
EP 1447
DI 10.1002/ptr.6335
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IA2PF
UT WOS:000469402900017
PM 30848530
DA 2026-05-27
ER

PT J
AU Xie, H
   Shen, CY
   Jiang, JG
AF Xie, Hong
   Shen, Chun-Yan
   Jiang, Jian-Guo
TI The sources of salidroside and its targeting for multiple chronic
   diseases
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Salidroside; Neuroprotection protection; Cardiovascular protection;
   Anticancer; Anti-inflammatory; Liver and kidney protection
ID ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS; SIGNALING PATHWAY;
   RHODIOLA-ROSEA; ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS; PI3K/AKT PATHWAY;
   NATURAL-PRODUCTS; RAT-LIVER; IN-VITRO
AB Salidroside, a phenolic compound widely existing in tubers of Rhodiola plants, has been found to have many important biological activities recently. This review summarizes the chemical synthesis and biosynthesis methods of salidroside, and introduces its pharmacological effects on diseases of liver, kidney, nervous and cardiovascular systems. A significant of studies have shown that salidroside has treatment effects on neurological diseases such as hypoxic-ischemic brain and degenerative diseases. It can prevent cardiovascular diseases by protecting cardiomyocytes and vascular endothelial cells. Salidroside can inhibit the release of oxidative stress and inflammatory factors, hence exerting protective function on liver and kidney. In addition, salidroside displays an anti-inflammatory effect by regulating the signaling pathways of NF-kappa B, JAK2-STAT3 and AMPK-SirT1. It can also promote cancer cell apoptosis and inhibit cancer cell proliferation. In conclusion, although the multiple bioactivities of salidroside are conformed, the clinical data are insufficient and needs to be concerned in the future.
C1 [Xie, Hong; Shen, Chun-Yan; Jiang, Jian-Guo] South China Univ Technol, Coll Food Sci & Bioengn, Guangzhou 510640, Peoples R China.
C3 South China University of Technology
RP Shen, CY; Jiang, JG (corresponding author), South China Univ Technol, Coll Food Sci & Bioengn, Guangzhou 510640, Peoples R China.
EM 201610104045@mail.scut.edu.cn; jgjiang@scut.edu.cn
RI ; Shen, Chun-Yan/GZH-0001-2022
OI Jiang, Jian-Guo/0000-0002-3361-6149; 
FU Science and Technology Project of Guangzhou City in China [201604020150]
FX The authors gratefully acknowledge the financial support from the
   Science and Technology Project of Guangzhou City in China
   (201604020150).
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NR 108
TC 21
Z9 25
U1 8
U2 115
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2020
VL 64
AR 103648
DI 10.1016/j.jff.2019.103648
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KE3WY
UT WOS:000508491000005
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wu, QW
   Shan, XH
   Li, XM
   Guan, J
   Song, FX
   Zhou, XY
   Fan, YY
   Guo, LM
AF Wu, Qingwei
   Shan, Xiaohang
   Li, Xuemei
   Guan, Jian
   Song, Fanxu
   Zhou, Xinyu
   Fan, Yingying
   Guo, Lanmin
TI Salidroside ameliorates neuroinflammation in autistic rats by inhibiting
   NLRP3/Caspase-1/GSDMD signal pathway
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE ASD; Salidroside; Pyroptosis; NLRP3; Hippocampus
ID SPECTRUM DISORDER; GASDERMIN D
AB Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that place a huge economic and emotional burden on society. Salidroside (Sal) has been reported to have therapeutic effects in a variety of neurological disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD), however no studies have been conducted to show whether salidroside is effective in ASD. Pyroptosis is involved in the pathology of a variety of neurological disorders, but has not been reported in ASD. Objectives: The aim of this study was to investigate whether pyroptosis is involved in the pathological mechanisms of ASD, and whether salidroside has an impact on the pathological process of ASD by regulating pyroptosis. Methods: We obtained a rat model of offspring ASD by prenatal intraperitoneal administration of valproic acid (VPA, 500 mg/kg) to pregnant rats, and we treated seven-day-old offspring ASD with salidroside (Sal, 30 mg/kg once daily) by gavage for 28 days as the salidroside treatment group. We examined the hippocampal state of ASD rats and the effect of salidroside on the hippocampus of VPA-induced ASD rats. In addition, in BV2 cells treated with LPS/Nig, we explored the mechanisms by which salidroside regulates neuroinflammation and pyroptosis in vitro. Results: In vivo, we observed VPA-induced hippocampal neuronal damage and activation of the NLRP3/Caspase1/GSDMD signalling pathway in ASD rats, while salidroside alleviated neuronal damage in ASD rats. In vitro, we found that salidroside inhibited LPS/Nig-induced neuroinflammation and activation of the NLRP3/Caspase-1/ GSDMD signalling pathway. These results suggest that the therapeutic effect of salidroside on hippocampal damage in ASD rats may be related to NLRP3/Caspase-1/GSDMD-mediated pyroptosis. Conclusions: Our work showed that salidroside ameliorates hippocampal neurological damage in ASD rats by targeting NLRP3/Caspase-1/GSDMD-mediated pyroptosis, providing a potential therapy drug for ASD.
C1 [Wu, Qingwei; Shan, Xiaohang; Li, Xuemei; Guan, Jian; Song, Fanxu; Zhou, Xinyu; Fan, Yingying; Guo, Lanmin] Jiamusi Univ, Sch Rehabil Med, 6 Qiaobei Rd, Jiamusi 154002, Peoples R China.
C3 Jiamusi University
RP Guo, LM (corresponding author), Jiamusi Univ, Sch Rehabil Med, 6 Qiaobei Rd, Jiamusi 154002, Peoples R China.
EM 13339444900@163.com
RI ; song, fanxu/ABF-6971-2021
OI Guo, Lanmin/0009-0002-5250-9602; 
FU Heilongjiang Provincial Higher Education Institutions Basic Research
   Business Fund Research Project [2021-KYYWF-0613]
FX This work was supported by the Heilongjiang Provincial Higher Education
   Institutions Basic Research Business Fund Research Project
   (2021-KYYWF-0613) and the Excellent Master's and Doctoral
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NR 67
TC 5
Z9 5
U1 3
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD JAN
PY 2025
VL 220
AR 111132
DI 10.1016/j.brainresbull.2024.111132
EA DEC 2024
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA S9O5B
UT WOS:001401426600001
PM 39557220
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yang, YY
   Liang, FQ
   Gao, JY
   Li, J
   Jiang, CH
   Xie, W
   Wu, SJ
   Wang, Y
   Yi, J
AF Yang, Yuyang
   Liang, Fangqian
   Gao, Jingyuan
   Li, Jian
   Jiang, Chunhua
   Xie, Wei
   Wu, Shujuan
   Wang, Ya
   Yi, Jing
TI Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte
   Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE Myocardial ischemia/reperfusion injury; Salidroside; circ_0097682; AC16
   cells; Injury
AB Salidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_0097682, miR-671-5p, and F-box and ubiquitin-specific peptidase 46 (USP46) were detected by qRT-PCR. Protein expression was measured by Western blotting assay. The levels of IL-6, IL-1 & beta;, and TNF-& alpha; in cell supernatant were detected by enzyme-linked immunosorbent assays. Salidroside treatment relieved I/R-induced inhibitory effect on AC16 cell proliferation and promoting effects on cell apoptosis, inflammation, and oxidative stress. Salidroside inhibited circ_0097682 expression in I/R-treated AC16 cells. Salidroside-mediated inhibition of I/R-induced cell injury involved the downregulation of circ_0097682 expression. In addition, circ_0097682 bound to miR-671-5p in AC16 cells, and miR-671-5p inhibitors rescued salidroside pretreatment-mediated effects in I/R-treated AC16 cells. Moreover, miR-671-5p targeted USP46 in AC16 cells, and USP46 introduction partially relieved circ_0097682 depletion or salidroside pretreatment-induced effects in I/R-treated AC16 cells. Salidroside ameliorated I/R-induced AC16 cell injury by inhibiting the circ_0097682/miR-671-5p/USP46 pathway.
C1 [Yang, Yuyang; Li, Jian; Jiang, Chunhua; Xie, Wei; Wu, Shujuan; Wang, Ya; Yi, Jing] North China Univ Sci & Technol, Coll Tradit Chinese Med, Qinhuangdao, Peoples R China.
   [Liang, Fangqian; Gao, Jingyuan] North China Univ Sci & Technol, Affiliated Hosp, Dept Gen Practice, 73 Jianshe South Rd, Tangshan 063000, Hebei, Peoples R China.
C3 North China University of Science & Technology; North China University
   of Science & Technology
RP Gao, JY (corresponding author), North China Univ Sci & Technol, Affiliated Hosp, Dept Gen Practice, 73 Jianshe South Rd, Tangshan 063000, Hebei, Peoples R China.
EM gaojingyuan2009@126.com
FU Experimental study on the effect of salidroside on diabetes rats with
   coronary heart disease; Hebei Provincial Department of Health Project; 
   [20130062]
FX This work was supported by Experimental study on the effect of
   salidroside on diabetes rats with coronary heart disease. Hebei
   Provincial Department of Health Project (20130062).
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NR 38
TC 11
Z9 14
U1 1
U2 13
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD DEC
PY 2023
VL 23
IS 11-12
BP 406
EP 418
DI 10.1007/s12012-023-09808-3
EA SEP 2023
PG 13
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA U8PD4
UT WOS:001069823300001
PM 37740139
DA 2026-05-27
ER

PT J
AU Dong, HL
   Ijaz, M
   Mehmood, K
   Ali, MM
   Tian, FY
   Li, JK
   Ahmed, S
   Shaukat, A
   Chang, ZY
   Wu, QX
AF Dong, Hailong
   Ijaz, Muhammad
   Mehmood, Khalid
   Ali, Muhammad Muddassir
   Tian, Fayi
   Li, Jiakui
   Ahmed, Shakeel
   Shaukat, Aftab
   Chang, Zhenyu
   Wu, Qingxia
TI Protective Effects of Salidroside and Dexamethasone against
   E.coli-Induced Inflammatory Response on Endometrial
   Epithelium Cells in Yaks
SO PAKISTAN VETERINARY JOURNAL
LA English
DT Article
DE Dexamethasone; Endometrial epithelium cells; Inflammation; Salidroside;
   Yaks
ID MYOCARDIAL INJURY; BOS-GRUNNIENS; IN-VITRO; KAPPA-B; INFECTION
AB Endometritis is an inflammation of the uterus, which can reduce the reproductive performance in yaks. Salidroside is a natural monomer of Rhodiolarosea, it has anti-inflammatory, antioxidative and immune regulation properties. We conduct this study to investigate the effect of salidroside and dexamethasone on E. coli-induced inflammatory response on endometrial epithelium cells in yaks. For this purpose, the endometrial epithelial cells were cultured and dived into four groups: control group, E.coli group, salidroside group and dexamethasone group. The antioxidant response, cytokine assays and immunofluorescence staining analysis were performed. The results showed that the intracellular activities of SOD were decreased, while MDA contents were increased significantly in E.coli-induced inflammation group. Whereas, the MDA contents decreased and SOD increased in salidroside and dexamethasone supplement groups. Moreover, E. coli results in significantly increase in cytokine production. The TNF-alpha, IL-1 alpha, IL-6 and IL-10 levels in the cells treated with salidroside and dexamethasone were decreased significantly compared to those of the E.coli group. E. coil-induced inflammatory cells showed an increase in the level of TNF-alpha protein compared to control group. The salidroside administration reduced the TNF-alpha expression significantly just like dexamethasone. In conclusion, salidroside and dexamethasone play important role in regulating E. coli-induced inflammatory response in endometrial epithelium cells. Furthermore, salidroside treatment is encouraged for the control of endometritis, which may target to reduce the incidence of endometritis. (C) 2018 PVJ. All rights reserved
C1 [Dong, Hailong; Tian, Fayi; Li, Jiakui; Chang, Zhenyu; Wu, Qingxia] Tibet Agr & Anim Husb Univ, Anim Sci Coll, Linzhi 860000, Tibet, Peoples R China.
   [Ijaz, Muhammad] Univ Vet & Anim Sci, Dept Clin Med & Surg, Lahore 54000, Punjab, Pakistan.
   [Mehmood, Khalid] Islamia Univ Bahawalpur, Univ Coll Vet & Anim Sci, Bahawalpur 63100, Punjab, Pakistan.
   [Ali, Muhammad Muddassir] Univ Vet & Anim Sci, Inst Biochem & Biotechnol, Lahore 54600, Pakistan.
   [Ahmed, Shakeel] Huazhong Agr Univ, Lab Drug Discovery & Mol Engn, Dept Med Plants, Coll Plant Sci & Technol, Wuhan 430070, Hubei, Peoples R China.
   [Shaukat, Aftab] Huazhong Agr Univ, Dept Clin Vet Med, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.
C3 Xizang Agricultural & Animal Husbandry University; University of
   Veterinary & Animal Science - Pakistan; Islamia University of
   Bahawalpur; University of Veterinary & Animal Science - Pakistan;
   Huazhong Agricultural University; Huazhong Agricultural University
RP Chang, ZY; Wu, QX (corresponding author), Tibet Agr & Anim Husb Univ, Anim Sci Coll, Linzhi 860000, Tibet, Peoples R China.
EM zychang2014@sina.com; wuqx2014@sina.com
RI Li, Jiakui/HDN-1674-2022; AHMED, SHAKEEL/AAG-2097-2019; ali, muhammad
   muddassir/AAB-6665-2020; MEHMOOD, KHALID/Y-5882-2019; Ijaz,
   Muhammad/AAX-9864-2020; Shaukat, Aftab/ABH-1570-2021
OI Li, Jiakui/0000-0002-6065-6648; AHMED, SHAKEEL/0000-0003-0086-2279; ali,
   muhammad muddassir/0000-0001-7930-7782; MEHMOOD,
   KHALID/0000-0003-4720-8792; Ijaz, Muhammad/0000-0002-0628-7773; Shaukat,
   Aftab/0000-0003-1670-6916
FU Department of S & T of Tibet - Tibet A and AH University Fund
   [XZ2017ZRG-19(Z)]; Tibet Autonomous Region Science Fund [XZ2017ZRG-27];
   Key laboratory of clinical veterinary medicine in Tibet; Chinese
   Agricultural Research Systems [CARS-37]; National Key Research and
   Development Program of China [2016YFC0502004]
FX The study was supported by Department of S & T of Tibet - Tibet A and AH
   University Fund (XZ2017ZRG-19(Z)), Tibet Autonomous Region Science Fund
   (XZ2017ZRG-27), Key laboratory of clinical veterinary medicine in Tibet,
   National Key Research and Development Program of China (2016YFC0502004)
   and the Chinese Agricultural Research Systems (CARS-37).
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   Zhu LP, 2015, APOPTOSIS, V20, P1433, DOI 10.1007/s10495-015-1174-5
   Zhu LP, 2015, INFLAMMATION, V38, P1589, DOI 10.1007/s10753-015-0134-0
NR 21
TC 7
Z9 7
U1 0
U2 7
PU UNIV AGRICULTURE, FAC VETERINARY SCIENCE
PI FAISALABAD
PA UNIV AGRICULTURE, FAC VETERINARY SCIENCE, FAISALABAD, 00000, PAKISTAN
SN 0253-8318
EI 2074-7764
J9 PAK VET J
JI Pak. Vet. J.
PY 2019
VL 39
IS 1
BP 101
EP 105
DI 10.29261/pakvetj/2018.116
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA HM6XB
UT WOS:000459620300019
OA gold
DA 2026-05-27
ER

PT J
AU Li, T
   Xu, KW
   Liu, YF
AF Li, Tian
   Xu, Kewei
   Liu, Yifan
TI Anticancer effect of salidroside reduces viability through
   autophagy/PI3K/Akt and MMP-9 signaling pathways in human bladder cancer
   cells
SO ONCOLOGY LETTERS
LA English
DT Article
DE salidroside; bladder cancer; autophagy; phosphoinositide 3-kinase;
   matrix metalloproteinase-9
ID DOWN-REGULATION; BREAST-CANCER; T24 CELLS; APOPTOSIS; INHIBITION;
   EXPRESSION; INVASION; PROLIFERATION; MIGRATION; MUTATIONS
AB Salidroside has a wide range of pharmacological activities, including antitumor, anti-inflammatory, analgesic, antibacterial, antiviral and anti-fertility abilities. In the present study, the effects of salidroside on the viability and apoptosis of bladder cancer cells, and the potential underlying mechanisms, were examined. In the present study, treatment with salidroside reduced cell viability, and induced apoptosis and caspase-9/3 activation in the T24 human bladder carcinoma cell line. Salidroside induced autophagy, promoted the protein expression of nucleoporin p62 and the microtubule-associated proteins 1A/1B light chain 3B, suppressed phosphoinositide 3-kinase (PI3K) and phosphorylated protein kinase B (p-Akt) expression, inhibited matrix metalloproteinase-9 (MMP-9) expression and increased that of Bcl-2-associated X protein, which functions as an apoptosis regulator in T24 cells. In the present study, it was demonstrated that the effect of salidroside reduced the viability and induced the apoptosis of bladder cancer cells through the autophagy/PI3K/Akt and MMP-9 signaling pathways.
C1 [Li, Tian; Liu, Yifan] Guangzhou Med Univ, Affiliated Hosp 5, Dept Urol, 621 Gangwan Rd, Guangzhou 510700, Guangdong, Peoples R China.
   [Li, Tian; Liu, Yifan] Guangzhou Med Univ, Minimally Invas Tech & Prod Translat Ctr, Guangzhou 510700, Guangdong, Peoples R China.
   [Xu, Kewei] Sun Yat Sen Univ, Affiliated Hosp 2, Dept Urol, Guangzhou 510120, Guangdong, Peoples R China.
C3 Guangzhou Medical University; Guangzhou Medical University; Sun Yat Sen
   University
RP Li, T (corresponding author), Guangzhou Med Univ, Affiliated Hosp 5, Dept Urol, 621 Gangwan Rd, Guangzhou 510700, Guangdong, Peoples R China.
EM tianliedit@163.com
RI Xu, Kewei/MVX-7968-2025
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NR 39
TC 32
Z9 42
U1 0
U2 25
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD SEP
PY 2018
VL 16
IS 3
BP 3162
EP 3168
DI 10.3892/ol.2018.8982
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GQ7TE
UT WOS:000441948400050
PM 30127910
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, M
   Lu, ZH
   Cai, PA
   Zheng, L
   Zhao, JM
AF Sun, Miao
   Lu, Zhenhui
   Cai, Peian
   Zheng, Li
   Zhao, Jinmin
TI Salidroside enhances proliferation and maintains phenotype of articular
   chondrocytes for autologous chondrocyte implantation (ACI) via
   TGF-β/Smad3 Signal
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Chondrocytes; Proliferation; Phenotype; Autologous
   chondrocyte implantation; TGP-beta 1/Smad3 signal
ID COLLAGEN; EXPRESSION
AB Autologous chondrocyte implantation (ACI) is commonly used for the treatment of cartilage defects. Since the cell number for transplantation is limited, the expand culture of chondrocytes in vitro is needed. However, the phenotype of chondrocytes is easy to lose in monolayer cultured in vitro. Traditional growth factors such as transformation growth factor -beta 1 (TGF-beta 1) have been used for promoting the proliferation and maintained the phenotype of chondrocytes, but the high cost and functional heterogeneity limit their clinical application. It is of significant to develop substitutes that can accelerate proliferation and prevent dedifferentiation of chondrocytes for further study. In our present study, the effect of salidroside on proliferation and phenotype maintenance of chondrocytes and cartilage repair was investigated by performing the cell viability, morphology, glycosaminoglycan (GAG) synthesis, cartilage relative genes expression, macroscopic and histological analyzsis. The TGF-beta/smad3 signal which may involve in the protective effect of salidroside on chondrocytes was also detected by ELISA and qRT-PCR assays. The results indicated that salidroside could promote chondrocytes proliferation and enhance synthesis of cartilage extracellular matrix (ECM). Expression of collagen type I was significantly downregulated which suggesting that salidroside could prevent chondrocytes from dedifferentiation. The in vivo experiments for cartilage repair also indicated that in the treatment of salidroside, chondrocytes used for ACI significantly accelerated the hyaline cartilage repair. While in the absence of salidroside, the repaired cartilage is mainly the fibrous cartilage. Additional experiments demonstrated that salidroside promotes the proliferation and maintain the phenotype of chondrocytes by activate the TGF-beta/smad3 signal. Salidroside may be a potential agent for ACI to promote the proliferation and maintain the phenotype of chondrocytes expansion in vitro.
C1 [Sun, Miao; Lu, Zhenhui; Cai, Peian; Zheng, Li; Zhao, Jinmin] Guangxi Med Univ, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Affiliated Hosp 1, Nanning 530021, Peoples R China.
   [Sun, Miao; Zheng, Li] Guangxi Med Univ, Dept Pharm, Nanning 530021, Peoples R China.
   [Cai, Peian; Zhao, Jinmin] Guangxi Med Univ, Dept Orthopaed Trauma & Hand Surg, Affiliated Hosp 1, Nanning 530021, Peoples R China.
   [Zhao, Jinmin] Guangxi Med Univ, Guangxi Key Lab Regenerat Med, Affiliated Hosp 1, Nanning 530021, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University
RP Zheng, L; Zhao, JM (corresponding author), Guangxi Med Univ, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Affiliated Hosp 1, Nanning 530021, Peoples R China.
EM zhengli224@163.com; zhaojinmin@126.com
RI Cai, Peian/P-8020-2019; zhao, jin/LBH-0351-2024
FU National Key R&D Program of China [2018YFC1105900, 2016YFB700800];
   National Natural Science Fund of China [81860390]; Guangxi Science and
   Technology Base and Talent Special Project [GuikeAD17129012]; local
   Science and Technology Development Project leading by the central
   government (the three-D printing and digital medical platform)
   [GuikeZY18164004]; Guangxi Scientific Research and Technological
   Development Foundation [GuikeAB16450003]
FX This study was financially supported by National Key R&D Program of
   China (2018YFC1105900 and 2016YFB700800), National Natural Science Fund
   of China (Grant No. 81860390), the Guangxi Science and Technology Base
   and Talent Special Project (Grant No. GuikeAD17129012), the local
   Science and Technology Development Project leading by the central
   government (the three-D printing and digital medical platform, Grant No.
   GuikeZY18164004) and the Guangxi Scientific Research and Technological
   Development Foundation (Grant No. GuikeAB16450003).
CR [Anonymous], J BIOSCI BIOENG
   [Anonymous], CURR GENOMICS
   [Anonymous], PHARMACOECONOMICS
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NR 24
TC 17
Z9 20
U1 0
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2020
VL 122
AR 109388
DI 10.1016/j.biopha.2019.109388
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KA7VF
UT WOS:000506005800043
PM 31919041
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, XY
   Jin, LH
   Shen, N
   Xu, B
   Zhang, W
   Zhu, HL
   Luo, ZL
AF Zhao, Xingyu
   Jin, Lianhai
   Shen, Nan
   Xu, Bin
   Zhang, Wei
   Zhu, Hongli
   Luo, Zhengli
TI Salidroside Inhibits Endogenous Hydrogen Peroxide Induced Cytotoxicity
   of Endothelial Cells
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE endothelial injury model; salidroside; oxidative stress; apoptosis;
   hydrogen peroxide
ID INDUCED OXIDATIVE STRESS; APOPTOSIS; INJURY; HEMOGLOBIN; PROTECTS;
   DAMAGE
AB Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., shows potent antioxidant property. Herein, we investigated the protective effects of salidroside against hydrogen peroxide (H2O2)-induced oxidative damage in human endothelial cells (EVC-304). EVC-304 cells were incubated in the presence or absence of low steady states of H2O2 (3-4 mu M) generated by glucose oxidase (GOX) with or without salidroside. 3(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) assays were performed, together with Hoechst 33258 staining and flow cytometric analysis using Annexin-V and propidium iodide (PI) label. The results indicated that salidroside pretreatment attenuated endogenous H2O2 induced apoptotic cell death in EVC-304 cells in a dose-dependent pattern. Furthermore, Western blot data revealed that salidroside inhibited activation of caspase-3, 9 and cleavage of poly(ADP-ribose) polymerase (PARP) induced by endogenous H2O2. It also decreased the expression of Bax and rescued the balance of pro- and anti-apoptotic proteins. All these results demonstrated that salidroside may present a potential therapy for oxidative stress in cardiovascular and cerebrovascular diseases.
C1 [Zhao, Xingyu; Jin, Lianhai; Shen, Nan; Xu, Bin; Zhang, Wei; Luo, Zhengli] Jilin Med Coll, Jilin 132013, Peoples R China.
   [Zhu, Hongli] Northwest Univ, Coll Life Sci, Xian 710069, Peoples R China.
   [Zhu, Hongli] Northwest Univ, Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Peoples R China.
C3 Jilin Medical University; Northwest University Xi'an; Northwest
   University Xi'an
RP Luo, ZL (corresponding author), Jilin Med Coll, Jilin 132013, Peoples R China.
EM jlmpcxlx@163.com; zhuyjw1971@nwu.edu.cn
FU Science Research Fund of Department of Education of Jilin Province
   [2008265, 2009311, 2012335, 2008051, 2012334]; National High-Tech R&D
   Program (863 Program) [2012AA021902]; National Natural Science
   Foundation of China [81102367]; "Science and Technology Research and
   Development Project" of Shaanxi Province [2011KTCL03-23, 2011K12-03-10];
   Xi'an Science and Technology Bureau [CXY1131]
FX This study was supported by a Grant from Science Research Fund of
   Department of Education of Jilin Province (No. 2008265, No. 2009311, No.
   2012335, No. 2008051 and No. 2012334). Authors also acknowledge grant
   support from the following: National High-Tech R&D Program (863 Program)
   (Program Number: 2012AA021902), National Natural Science Foundation of
   China (Program Number: 81102367), the "Science and Technology Research
   and Development Project" of Shaanxi Province (Grant No. 2011KTCL03-23
   and 2011K12-03-10), and Xi'an Science and Technology Bureau (Grant No.
   CXY1131).
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NR 27
TC 23
Z9 25
U1 0
U2 14
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD NOV
PY 2013
VL 36
IS 11
BP 1773
EP 1778
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 244AQ
UT WOS:000326359900020
PM 23965749
DA 2026-05-27
ER

PT J
AU Song, TX
   Wang, PL
   Li, CY
   Jia, L
   Liang, QQ
   Cao, YL
   Dong, PZ
   Shi, H
   Jiang, MM
AF Song, Tongxin
   Wang, Pengli
   Li, Chenyang
   Jia, Li
   Liang, Qianqian
   Cao, Yuanlin
   Dong, Pengzhi
   Shi, Hong
   Jiang, Miaomiao
TI Salidroside simultaneously reduces de novo lipogenesis and cholesterol
   biosynthesis to attenuate atherosclerosis in mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Atherosclerosis; Salidroside; Dyslipidemia; Sterol regulatory
   element-binding proteins; ATP citrate lyase
AB Salidroside is a kind of phenylethanoid glycoside and widespread in the plants from Rhodiola and Ligustrum species. Our previous study has reported that salidroside can prevent atherosclerosis progression by ameliorating glyerolipid and glycerophospholipid metabolism in apoE-deficient (apoE(-/-)) mice. However, its effect on neutral lipids and underlying mechanism remains largely unclear. Here we investigated the molecular mechanism of salidroside action from the perspective of metabolic regulation by integrating metabonomics and transcriptomics pattern. The results showed that salidroside significantly reduced cholesterols, esterified cholesterols, fatty acids, unsaturated fatty acids and triacylclycerols biosynthesis in liver through down-regulating the genes expressions of sterol regulatory element-binding proteins (Srebf1 and Srebf2). The expressions of SREBPs targeted and downstream genes, such as the encoding genes of fatty acid synthase (Fasn), glycerol-3-phosphate acyltransferase (Gpam), stearoyl-CoA desaturase (Scd), 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), and proprotein convertase subtilisin/kexin type 9 (Pcsk9), were also inhibited after salidroside administration. ATP citrate lyase gene (Acly) that encodes an important enzyme producing acetyl-CoA for cholesterol and fatty acid biosynthesis significantly decreased after treatment as well. Moreover, one of ketone body products, 3-hydroxybutyrate, was significantly up-regulated in drug-treated group, indicating that fatty acid degradation was accelerated by salidroside at the same time. Our findings identify salidroside as a regulator of lipid homeostasis in atherosclerotic mice, suggesting its potential to be an alternative medicine for lowering the risks of atherosclerosis-related diseases.
C1 [Song, Tongxin; Wang, Pengli; Jia, Li; Liang, Qianqian; Cao, Yuanlin; Dong, Pengzhi; Shi, Hong; Jiang, Miaomiao] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China.
   [Li, Chenyang] Shenzhen Univ, Sch Med, Dept Pharm, Shenzhen 518060, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Shenzhen University
RP Jiang, MM (corresponding author), Tianjin Univ Tradit Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.
EM miaomiaojiang@tjtcm.edu
RI Dong, Pengzhi/JKH-4976-2023; Li, Jia/A-9852-2011
FU Natural Science Foundation of Tianjin [18JCZDJC97700]; National Key
   Research and Development Project of China [2018YFC1707403]; Tianjin
   Science and Technology Project [20ZYJDJC00120]
FX This study was supported by the Natural Science Foundation of Tianjin
   (No. 18JCZDJC97700), the National Key Research and Development Project
   of China (No. 2018YFC1707403) and the Tianjin Science and Technology
   Project (No. 20ZYJDJC00120).
CR Grundy SM, 2019, CIRCULATION, V139, pE1046, DOI [10.1161/CIR.0000000000000624, 10.1016/j.jacc.2018.11.002]
NR 1
TC 47
Z9 54
U1 3
U2 52
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2021
VL 134
AR 111137
DI 10.1016/j.biopha.2020.111137
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PY7MF
UT WOS:000612225500006
PM 33341055
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, H
   Zhu, J
   Le, YF
   Pan, JL
   Liu, Y
   Liu, ZJ
   Wang, C
   Dou, XB
   Lu, DZ
AF Chen, Hang
   Zhu, Ji
   Le, Yifei
   Pan, Jieli
   Liu, Ying
   Liu, Zhijun
   Wang, Cui
   Dou, Xiaobing
   Lu, Dezhao
TI Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a
   ferroptosis-dependent pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Doxorubicin-induced cardiomyopathy; Ferroptosis Salidroside;
   Cardiomyocytes; AMPK signaling pathway; Mitochondria
ID AMPK ACTIVATION; HEART; CARDIOTOXICITY; MITOCHONDRIA; INFLAMMATION;
   MECHANISM; FAILURE; TARGET; SENSOR; DEATH
AB Background: Doxorubicin-induced cardiotoxicity (DIC) limits the clinical application of the drug in treatment of cancers and imposes a severe health burden on the patients. Therefore, there is an urgent need to develop alternative therapeutic strategies or drugs to minimize DIC. Salidroside is a phenylpropanoid glycoside extracted from Rhodiola rosea with multiple biological effects such as anti-inflammation and antioxidant properties. However, its mechanism of action in DIC is still poorly understood.
   Purpose: The present study was aimed to investigate the role of salidroside in DIC and associated mechanism of action for the described effects.
   Methods: Cardiac dysfunction was induced through treatment of mice with doxorubicin in vivo and in vitro. The mechanism of action of salidroside was investigated using western blot assay, qPCR, immunofluorescence, histochemistry, echocardiography, and high-content imaging system.
   Results: Results of the current study found that treatment of mice with salidroside significantly improved doxorubicin-induced cardiac dysfunction, ferroptosis-like cell damage, and fibrosis in vivo. Further, it was noted that salidroside inhibited ferroptosis in vivo and in vitro by limiting iron accumulation, restoring GPX4-dependent antioxidant capacity, and preventing lipid peroxidation at the cellular or mitochondrial levels. Mechanistically, salidroside inhibited DOX-induced mitochondrial ROS, Fe2+, and lipid peroxidation as well as restored mito-chondrial membrane potential by promoting mitochondrial biogenesis, improving mitochondrial iron-sulfur clusters, and restoring mitochondrial OXPHOS complexes, thereby improving mitochondrial function. In addition, AMPK is a key protein that coordinates mitochondria, metabolism, and ferroptosis. Therefore, it was found that compound C (CC), an AMPK inhibitor, disrupted the regulation of cellular lipid metabolism and mito-chondrial function of salidroside as well as led to failure of the protective effect of salidroside against ferroptotic cell death.
   Conclusions: The present study evidently demonstrated the cardioprotective effects of salidroside against doxorubicin-induced cardiomyopathy. Further, salidroside markedly down-regulated ferroptotic cell death by activating AMPK-dependent signaling pathways including regulating abnormal fatty acid metabolism and maintaining mitochondrial function. Therefore, salidroside is can be exploited to develop a novel medication for clinical DIC and salidroside may represent a novel treatment that improves recovery from DIC by targeting ferroptosis.
C1 [Chen, Hang; Le, Yifei; Liu, Ying; Liu, Zhijun; Wang, Cui; Dou, Xiaobing; Lu, Dezhao] Zhejiang Chinese Med Univ, Sch Life Sci, Hangzhou 310053, Peoples R China.
   [Zhu, Ji] Zhejiang Chinese Med Univ, Zhongshan Hosp Zhejiang Prov, Affiliated Hosp 3, Hangzhou 330106, Peoples R China.
   [Pan, Jieli] Zhejiang Chinese Med Univ, Acad Chinese Med Sci, Hangzhou 310053, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Chinese Medical University
RP Lu, DZ (corresponding author), Zhejiang Chinese Med Univ, Sch Life Sci, Hangzhou 310053, Peoples R China.
EM ludezhao@126.com
FU Medical and health research program of the third affiliated hospital of
   Zhejiang Chinese Medicine University [yrczx202005-01]; Scientific
   Research and Innovation Fund of Zhejiang Chinese Medicine University
   [KC201946]; Key Laboratory of Integrative Chinese and Western Medicine
   for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang
   Province [2C32005]
FX This research was supported by Medical and health research program of
   the third affiliated hospital of Zhejiang Chinese Medicine University
   (yrczx202005-01), Scientific Research and Innovation Fund of Zhejiang
   Chinese Medicine University (KC201946), and Key Laboratory of
   Integrative Chinese and Western Medicine for the Diagnosis and Treatment
   of Circulatory Diseases of Zhejiang Province (2C32005).
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NR 51
TC 98
Z9 108
U1 6
U2 113
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAY
PY 2022
VL 99
AR 153964
DI 10.1016/j.phymed.2022.153964
EA FEB 2022
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1B1NB
UT WOS:000792208600002
PM 35180677
DA 2026-05-27
ER

PT J
AU Chen, MY
   Cai, H
   Yu, C
   Wu, PL
   Fu, YY
   Xu, XM
   Fan, R
   Xu, CL
   Chen, YF
   Wang, LX
   Huang, XY
AF Chen, Mayun
   Cai, Hui
   Yu, Chang
   Wu, Peiliang
   Fu, Yangyang
   Xu, Xiaomei
   Fan, Rong
   Xu, Cunlai
   Chen, Yanfan
   Wang, Liangxing
   Huang, Xiaoying
TI Salidroside exerts protective effects against chronic hypoxia-induced
   pulmonary arterial hypertension via AMPKα1-dependent pathways
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Salidroside; pulmonary arterial hypertension; AMPK alpha 1; apoptosis;
   proliferation
ID ACTIVATED PROTEIN-KINASE; SMOOTH-MUSCLE-CELLS; INHIBITS
   CARDIAC-HYPERTROPHY; RHODIOLA-ROSEA; AMPK; APOPTOSIS; PRESSURE;
   PROLIFERATION; MECHANISMS; RESISTANCE
AB Salidroside, an active ingredient isolated from Rhodiola rosea, has shown to exert protective effects against chronic hypoxia-induced pulmonary arterial hypertension (PAH). However, the underlying mechanisms were not well known. Based on our recent reports, we predicted the involvement of adenosine monophosphate-activated protein kinase (AMPK) mediated effects in salidroside regulation of PAH. Firstly, to prove the hypothesis, rats were exposed to chronic hypoxia and treated with increasing concentrations of salidroside or a selective AMPK activator-5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) for 4 weeks. After salidroside or AICAR treatment, the chronic hypoxia-induced right ventricular hypertrophy and pulmonary artery remodeling were attenuated. Then the effects of salidroside or AICAR on hypoxia-induced excess cellular proliferation and apoptosis resistance of pulmonary arterial smooth muscle cells (PASMCs), which contributed to pulmonary arterial remodeling, were investigated. Our results suggested salidroside, as well as AICAR, reversed hypoxia-induced PASMCs proliferation and apoptosis resistance while AMPK inhibitor Compound C enhanced the effects of hypoxia. To reveal the potential cellular mechanisms, activation of AMPK alpha 1 and expression of the genes related to proliferation and apoptosis were analyzed in PASMCs after salidroside treatment under hypoxia conditions. The results demonstrated salidroside as well as AICAR might inhibit chronic hypoxia-induced PASMCs proliferation via AMPK alpha 1-P53-P27/P21 pathway and reverse apoptosis resistance via AMPK alpha 1-P53-Bax/Bcl-2-caspase 9-caspase 3 pathway.
C1 [Chen, Mayun; Cai, Hui; Wu, Peiliang; Fu, Yangyang; Xu, Xiaomei; Fan, Rong; Xu, Cunlai; Chen, Yanfan; Wang, Liangxing; Huang, Xiaoying] Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Key Lab Heart & Lung, Wenzhou 325000, Zhejiang, Peoples R China.
   [Yu, Chang] Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiol, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Wang, LX; Huang, XY (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Key Lab Heart & Lung, Wenzhou 325000, Zhejiang, Peoples R China.
EM wzyxywlx@163.com; drhuangxy@163.com
RI Xu, Cunlai/JEZ-3397-2023
OI Xu, Cunlai/0000-0003-2405-6159; Huang, Xiaoying/0000-0003-4854-0922;
   Lai, Yichang/0009-0007-3727-8734
FU National Natural Science Foundation of China [81473406]; Natural Science
   Foundation of Zhejiang Province [LY13H010003]; Science and Technology
   Project of Wenzhou [Y20100190]; Zhejiang Province Health Department
   [2012ZDA035]
FX This study was supported by the National Natural Science Foundation of
   ChinaGrants (No. 81473406), the Natural Science Foundation of Zhejiang
   Province Grants (LY13H010003), and Science and Technology Project of
   Wenzhou (No. Y20100190), Project of Zhejiang Province Health Department
   (No. 2012ZDA035).
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NR 44
TC 49
Z9 58
U1 1
U2 15
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2016
VL 8
IS 1
BP 12
EP 27
PG 16
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA DE1EN
UT WOS:000370369600002
PM 27069536
DA 2026-05-27
ER

PT J
AU Wang, CY
   Sun, ZN
   Wang, MX
   Zhang, C
AF Wang, Chun-Yang
   Sun, Zhao-Nan
   Wang, Ming-Xin
   Zhang, Chao
TI SIRT1 mediates salidroside-elicited protective effects against
   MPP+-induced apoptosis and oxidative stress in SH-SY5Y cells:
   involvement in suppressing MAPK pathways
SO CELL BIOLOGY INTERNATIONAL
LA English
DT Article
DE apoptosis; mitogen-activated protein kinase pathways; oxidative stress;
   Parkinson's disease; salidroside; silent information regulator 1
ID PARKINSONS-DISEASE; P38 MAPK; NEURODEGENERATIVE DISEASES;
   ALPHA-SYNUCLEIN; MODELS; MECHANISMS; INFLAMMATION; INHIBITION;
   METABOLITE; EXPRESSION
AB Parkinson's disease (PD) is a progressive neurodegenerative disease, leading to tremor, rigidity, bradykinesia, and gait impairment. Salidroside has been reported to exhibit antioxidative and neuroprotective properties in PD. However, the underlying neuroprotective mechanisms effects of salidroside are poorly understood. Recently, a growing body of evidences suggest that silent information regulator 1 (SIRT1) plays important roles in the pathophysiology of PD. Hence, the present study investigated the roles of SIRT1 in neuroprotective effect of salidroside against N-methyl-4-phenylpyridinium (MPP+)-induced SH-SY5Y cell injury. Our findings revealed that salidroside attenuates MPP+-induced neurotoxicity as evidenced by the increase in cell viability, and the decreases in the caspase-3 activity and apoptosis ratio. Simultaneously, salidroside pretreatment remarkably increased SIRT1 activity, SIRT1 mRNA and protein levels in MPP+-treated SH-SY5Y cell. However, sirtinol, a SIRT1 activation inhibitor, significantly blocked the inhibitory effects of salidroside on MPP+-induced cytotoxicity and apoptosis. In addition, salidroside abolished MPP+-induced the production of reactive oxygen species (ROS), the up-regulation of NADPH oxidase 2 (NOX2) expression, the down-regulations of superoxide dismutase (SOD) activity and glutathione (GSH) level in SH-SY5Y cells, while these effects were also blocked by sirtinol. Finally, we found that the inhibition of salidroside on MPP+-induced phosphorylation of p38, extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK) were also reversed by sirtinol in SH-SY5Y cells. Taken together, these results indicated that SIRT1 contributes to the neuroprotection of salidroside against MPP+-induced apoptosis and oxidative stress, in part through suppressing of mitogen-activated protein kinase (MAPK) pathways.
C1 [Wang, Chun-Yang] Tianjin Med Univ, Gen Hosp, Dept Sci & Technol, Tianjin 300052, Peoples R China.
   [Sun, Zhao-Nan] Tianjin Med Univ, Gen Hosp, Dept Gen Surg, Tianjin 300052, Peoples R China.
   [Wang, Ming-Xin] Tianjin Med Univ, Gen Hosp, Dept Otolaryngol, Tianjin 300052, Peoples R China.
   [Zhang, Chao] Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin 300052, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Tianjin Medical
   University; Tianjin Medical University
RP Zhang, C (corresponding author), Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin 300052, Peoples R China.
EM zhchao0923@qq.com
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NR 48
TC 35
Z9 42
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-6995
EI 1095-8355
J9 CELL BIOL INT
JI Cell Biol. Int.
PD JAN
PY 2018
VL 42
IS 1
BP 84
EP 94
DI 10.1002/cbin.10864
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FT0TK
UT WOS:000422840600011
PM 28851138
DA 2026-05-27
ER

PT J
AU Sun, KX
   Xia, HW
   Xia, RL
AF Sun, Kuan-Xue
   Xia, Hong-Wei
   Xia, Rong-Long
TI Anticancer effect of salidroside on colon cancer through inhibiting
   JAK2/STAT3 signaling pathway
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Colon carcinoma; salidroside; apoptosis; invasion; JAK2/STAT3
ID CELLS; ACTIVATION; EXPRESSION; STAT3; MICE; ANGIOGENESIS; METASTASIS;
   TRANSDUCER; INDUCTION; APOPTOSIS
AB Salidroside is considered to have anti-tumor properties. We investigate its effects on colon carcinoma SW1116 cells. Cell viability was assessed by CCK-8. Propidium iodide (PI) staining was used to determine the cell cycle by flow cytometry. The migration and invasion were detected by Transwell. Western blot was used to detect the expression of STAT3 signal related proteins. As the result, high concentrations of salidroside (10, 20. 50 mu g/ml) significantly inhibited proliferation of SW1116 cells in a parallelly, cell cycle arrest was increased at the G0/G1 phase after salidroside treatment. Furthermore, salidroside inhibited migration and invasion of SW1116 cells. Salidroside treatment decreased proteins expression of phosphorylation levels in JAK2/STAT3 signaling, while MMP2 and MMP-9 proteins levels were decreased and protein expression of VEGF and VEGFR-2 were down-regulated. In Conclusion, salidroside inhibited proliferation, decreased the migration and invasion of SW1116 cells in JAK2/STAT3-dependent pathway, the specific mechanisms need further study.
C1 [Sun, Kuan-Xue; Xia, Hong-Wei; Xia, Rong-Long] Gongli Hosp Shanghai Pu Dong New Dist, Dept Gen Surg, Shanghai 200135, Peoples R China.
   [Sun, Kuan-Xue; Xia, Hong-Wei; Xia, Rong-Long] Gongli Hosp Shanghai Pu Dong New Dist, Dept Ultrasound Diag, Shanghai 200135, Peoples R China.
RP Xia, RL (corresponding author), Gongli Hosp Shanghai Pu Dong New Dist, Dept Gen Surg, 219 Miao Pu Rd, Shanghai 200135, Peoples R China.
EM xiaronglong@163.com
CR Bill MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040724
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NR 28
TC 54
Z9 66
U1 0
U2 9
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2015
VL 8
IS 1
BP 615
EP 621
PG 7
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA CB7WG
UT WOS:000349838700066
PM 25755753
DA 2026-05-27
ER

PT J
AU Zhang, YS
   Yao, YY
   Wang, HJ
   Guo, YQ
   Zhang, H
   Chen, L
AF Zhang, Yanshan
   Yao, Yunyi
   Wang, Huijuan
   Guo, Yanqin
   Zhang, Hui
   Chen, Liang
TI Effects of salidroside on glioma formation and growth inhibition
   together with improvement of tumor microenvironment
SO CHINESE JOURNAL OF CANCER RESEARCH
LA English
DT Article
DE Glioma; salidroside; cytotoxicity; cell cycle; xenotransplantation;
   oxidative stress; astrocyte; tumor microenvironment
ID MOUSE MODELS; CANCER; TEMOZOLOMIDE; MANAGEMENT; ASTROCYTES; DISEASE
AB Objective: To test the effects of salidroside on formation and growth of glioma together with tumor microenvironment.
   Methods: Salidroside extracted from Rhodiola rosea was purified and treated on human glioma cells U251 at the concentration of 20 mu g/mL. 3-(4,5-dimethylthiazol-2-yl)-2,5-dephenyltetrazolium bromide (MTT) assay for cytotoxicity and flow cytometry (FCM) for cell cycle analysis were performed. Then for in vivo study, xenotransplantation tumor model in nude mice was generated and treated with salidroside at the concentration of 50 mg/kg.d for totally 20 d. Body weight and tumor size were detected every 2 d after the treatment. The levels of 8-isoprostane, superoxide dismutase (SOD) and malondialdehyde (MDA), special markers for oxidative stress, were detected while immunofluoresence staining was performed for astrocyte detection.
   Results: For in vitro study, salidroside could decrease the viability of human glioma cells U251 and the growth of U251 cells at G(0)/G(1) checkpoint during the cell cycle. For in vivo study, salidroside could also inhibit the growth of human glioma tissue in nude mice. The body weight of these nude mice treated with salidroside did not decrease as quickly as control group. In the tumor xenotransplantation nude mice model, mice were found of inhibition of oxidative stress by detection of biomarkers. Furthermore, overgrowth of astrocytes due to the stimulation of oxidative stress in the cortex of brain was inhibited after the treatment of salidroside.
   Conclusions: Salidroside could inhibit the formation and growth of glioma both in vivo and in vitro and improve the tumor microenvironment via inhibition of oxidative stress and astrocytes.
C1 [Zhang, Yanshan] Wuwei Tumor Hosp, Dept Gastr Surg, Wuwei 733000, Peoples R China.
   [Yao, Yunyi] Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Jiangsu Key Lab Brain Dis Bioinfomat, Xuzhou 221004, Peoples R China.
   [Wang, Huijuan] Wuwei Tumor Hosp, Dept Tumor Chemotherapy, Wuwei 733000, Peoples R China.
   [Guo, Yanqin] Mudanjiang Med Univ, Hongqi Hosp, Dept Neurol, Mudanjiang 157011, Peoples R China.
   [Zhang, Hui] 97th Hosp Chinese PLA, Dept Endocrinol, Xuzhou 221004, Peoples R China.
   [Chen, Liang] Dalian Med Univ, Affiliated Hosp 2, Dept Resp Med, Dalian 116023, Peoples R China.
C3 Xuzhou Medical University; Mudanjiang Medical University; Dalian Medical
   University
RP Yao, YY (corresponding author), Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Jiangsu Key Lab Brain Dis Bioinfomat, Xuzhou 221004, Peoples R China.
EM yaoyunyiyyy@126.com; yanqinguo@sina.com
RI Chen, Liang/LZI-1530-2025
OI zhang, yanshan/0000-0003-4621-148X
FU National Natural Science Foundation of China [81141080]; Jiangsu
   Provincial Natural Science Foundation [SBK201340596]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81141080) and Jiangsu Provincial Natural Science Foundation
   (SBK201340596)).
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NR 22
TC 39
Z9 45
U1 1
U2 24
PU CHINESE JOURNAL CANCER RESEARCH CO
PI BEIJING
PA LTD PEKING U CANCER HOSP & INST, NO 52, FUCHENG RD, HAIDIAN, BEIJING,
   100142, PEOPLES R CHINA
SN 1000-9604
EI 1993-0631
J9 CHINESE J CANCER RES
JI Chin. J. Cancer Res.
PD OCT
PY 2013
VL 25
IS 5
BP 520
EP 526
DI 10.3978/j.issn.1000-9604.2013.10.01
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 250KT
UT WOS:000326852400008
PM 24255575
DA 2026-05-27
ER

PT J
AU Wu, YF
   Wang, Y
   Wu, YR
   Li, TT
   Wang, W
AF Wu, Yanfen
   Wang, Yong
   Wu, Yarui
   Li, Tingting
   Wang, Wei
TI Salidroside shows anticonvulsant and neuroprotective effects by
   activating the Nrf2-ARE pathway in a pentylenetetrazol-kindling
   epileptic model
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE salidroside; anticonvulsant; cognitive dysfunction; Nrf2-ARE signal
   pathway; oxidative stress; neuroinflammation
ID COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; RHODIOLA-ROSEA; DISEASE;
   PROTECTS; SEIZURES; DEFICITS; NEURONS; BRAIN
AB Evidence points towards oxidative stress and neuroinflammation being major processes associated with brain dysfunction in epilepsy. Salidroside reportedly possesses anti-oxidative activity and neuroprotective potential, in addition to exerting an anti-neuroinflammatory response. This study was designed to evaluate the anticonvulsant and neuroprotective role of salidroside in rats with pentylenetetrazole (PTZ) kindling and to explore the underlying mechanism. Male Wistar rats were administered a sub-convulsive dose of PTZ (35 mg/kg) every other day for 15 injections, and salidroside (50 mg/kg) was injected intraperitoneally along with alternate-day PTZ. The seizure degree, cognitive function, and number of hippocampal neurons were investigated. The expression of nuclear factor erythroid 2-related factor- antioxidant response element (Nrf2-ARE) signaling pathways, oxidative stress parameters and inflammatory cytokines were also observed. Our study showed that salidroside treatment suppressed the kindling acquisition process, ameliorated cognitive impairment, and rescued the number of pyramidal neurons in the CA3 regions. Salidroside treatment could activate the Nrf2-ARE signal pathway, and suppressed oxidative stress and neuroinflammation. Our findings demonstrated that salidroside exerted anticonvulsant and neuroprotective effects in epileptic rats by activating the Nrf2-ARE signal pathway.
C1 [Wu, Yanfen; Wu, Yarui] Peking Univ, Aerosp Ctr Hosp, Hlth Management Dept, Aerosp Clin Coll, Beijing, Peoples R China.
   [Wang, Yong] China Med Univ, Dept Anesthesiol, Pain Med & Crit Care Med, Aviat Gen Hosp, Beijing, Peoples R China.
   [Wang, Yong] Chinese Acad Sci, Beijing Inst Translat Med, Beijing, Peoples R China.
   [Li, Tingting; Wang, Wei] Capital Med Univ, Xuan Wu Hosp, Inovat Ctr Neurol Disorders, Dept Neurol, Beijing, Peoples R China.
C3 Peking University; China Medical University; Chinese Academy of
   Sciences; Capital Medical University
RP Wang, W (corresponding author), Capital Med Univ, Xuan Wu Hosp, Inovat Ctr Neurol Disorders, Dept Neurol, Beijing, Peoples R China.
EM wangwei76@xwhosp.org
FU Research and Development Fund of Capital Medical University [PYZ2018062]
FX This project was financially supported by the Research and Development
   Fund of Capital Medical University (PYZ2018062)
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NR 43
TC 38
Z9 41
U1 1
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD NOV
PY 2020
VL 164
BP 14
EP 20
DI 10.1016/j.brainresbull.2020.08.009
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA OH2JL
UT WOS:000582395500002
PM 32800786
DA 2026-05-27
ER

PT J
AU Zhong, ZF
   Han, J
   Zhang, JZ
   Xiao, Q
   Chen, JY
   Zhang, K
   Hu, J
   Chen, LD
AF Zhong, Zhi-feng
   Han, Jing
   Zhang, Ji-Zhou
   Xiao, Qing
   Chen, Jing-yan
   Zhang, Kai
   Hu, Juan
   Chen, Li-dian
TI Neuroprotective Effects of Salidroside on Cerebral
   Ischemia/Reperfusion-Induced Behavioral Impairment Involves the
   Dopaminergic System
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; neuroprotection; cerebral ischemia; reperfusion;
   dopaminergic system; microdialysis
ID SUBSTANTIA-NIGRA; RAT MODEL; STRIATAL INFARCTION; FOCAL ISCHEMIA;
   RHODIOLA-ROSEA; MOTOR FUNCTION; IN-VIVO; BRAIN; NEURONS; STROKE
AB Salidroside, a phenylpropanoid glycoside, is the main bioactive component of Rhodiola rosea L. Salidroside has prominent anti-stroke effects in cerebral ischemia/reperfusion models. However, the underlying mechanisms of its actions are poorly understood. This study examined the anti-stroke effects of salidroside in middle cerebral artery occlusion (MCAO)-induced rat model of stroke and its potential mechanisms involving the dopaminergic system. Salidroside administration increased the levels of dopamine (DA), homovanillic acid (HVA), and 3,4-dihydroxyphenylacetic acid (DOPAC) in the ipsilateral striatum after induction of transient ischemia, which were assessed using microdialysis with high-performance liquid chromatography coupled with electrochemical detection (HPLC-ECD). Furthermore, treatment with salidroside ameliorated neurobehavioral impairment, assessed with the modified neurological severity scores (mNSS), the balance beam test, and the foot fault test. Moreover, enzyme-linked immunosorbent assay (ELISA) suggested that MCAO-induced reduction in monoamine oxidase (MAO) was inhibited by salidroside. Immunohistochemical and immunofluorescence analyses revealed high level of tyrosine hydroxylase (TH) in the ipsilateral striatal caudate putamen (CPu) after cerebral ischemia/reperfusion, which could be further elevated by salidroside. In addition, salidroside could reverse the decreased immunoreactivity of TH in the substantia nigra pars compacta (SNpc). These results suggest that the anti-stroke effects of salidroside in MCAO-induced cerebral ischemia/reperfusion may involve the modulation of monoamine metabolism in the striatum and SNpc, which may be related to the function of the dopaminergic system in the rat brain.
C1 [Zhong, Zhi-feng; Han, Jing; Zhang, Ji-Zhou; Xiao, Qing; Chen, Jing-yan; Zhang, Kai; Hu, Juan; Chen, Li-dian] Fujian Acad Tradit Chinese Med, Inst Mat Med, Fuzhou, Fujian, Peoples R China.
   [Zhong, Zhi-feng] Third Mil Med Univ, Army Med Univ, Coll High Altitude Mil Med, Dept High Altitude Operat Med, Chongqing, Peoples R China.
   [Zhong, Zhi-feng] Fujian Med Univ, Fujian Key Lab Nat Med Pharmacol, Fuzhou, Fujian, Peoples R China.
   [Hu, Juan; Chen, Li-dian] Fujian Univ Tradit Chinese Med, Sch Rehabil Med, Fuzhou, Fujian, Peoples R China.
C3 Army Medical University; Fujian Medical University; Fujian University of
   Traditional Chinese Medicine
RP Hu, J; Chen, LD (corresponding author), Fujian Acad Tradit Chinese Med, Inst Mat Med, Fuzhou, Fujian, Peoples R China.; Hu, J; Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Sch Rehabil Med, Fuzhou, Fujian, Peoples R China.
EM huj@fjtcm.edu.cn; cld@fjtcm.edu.cn
RI Zhang, Jizhou/N-8928-2019; Chen, Lidian/GSN-6461-2022; Zhang,
   Kai/AAU-7911-2021
OI Zhang, Jizhou/0000-0002-8831-501X; Han, Jing/0000-0002-7142-1991; Chen,
   Lidian/0000-0002-8699-0839; Zhong, Zhifeng/0000-0003-2793-6178; 
FU National Natural Science Foundation of China [81803870]; Fujian
   Provincial Science and Technology Department [2018R1035-11, 2018J01855,
   2019J01338]; Open Research Fund of Fujian Key Laboratory of Natural
   Medicine Pharmacology, Fujian Medical University [FJNMP-201801]; project
   of Fujian Province Office of Education [JZ160442]; Fujian Provincial
   Health and Family Planning Commission [2017-1-80]
FX This work was supported by the National Natural Science Foundation of
   China (grant no. 81803870), and Fujian Provincial Science and Technology
   Department(2018R1035-11, 2018J01855, 2019J01338), the Open Research Fund
   of Fujian Key Laboratory of Natural Medicine Pharmacology, Fujian
   Medical University (FJNMP-201801), and the project of Fujian Province
   Office of Education (JZ160442), the research project of Fujian
   Provincial Health and Family Planning Commission (2017-1-80).
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NR 69
TC 42
Z9 46
U1 1
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 13
PY 2019
VL 10
AR 1433
DI 10.3389/fphar.2019.01433
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JY9GC
UT WOS:000504713600001
PM 31920641
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shang, HX
   Wang, SN
   Yao, JM
   Guo, CC
   Dong, JJ
   Liao, L
AF Shang, Hongxia
   Wang, Shengnan
   Yao, Jinming
   Guo, Congcong
   Dong, Jianjun
   Liao, Lin
TI Salidroside inhibits migration and invasion of poorly differentiated
   thyroid cancer cells
SO THORACIC CANCER
LA English
DT Article
DE Invasion; migration; poorly differentiated thyroid cancer; salidroside
ID IN-VITRO; PROMOTES; APOPTOSIS; PATHWAY; PROLIFERATION; EXPRESSION;
   REVEALS; GROWTH; INJURY; MICE
AB Background No effective treatment is currently available for poorly differentiated thyroid cancer which is resistant to radioiodine, especially with migration and invasion. A great number of researches have revealed the anticancer effects of salidroside, but none have studied the effects of salidroside on thyroid cancer. This study aimed to investigate the effect of salidroside on migration and invasion of poorly differentiated thyroid cancer cells. Methods The effects of salidroside on migration, invasion and apoptosis of poorly differentiated thyroid cancer WRO cells and normal thyroid follicular epithelial Nthy-ori 3-1 cells were measured by wound-healing assay, transwell migration/invasion assay and flow cytometry, respectively. The expression levels of MMP2 and MMP9 at RNA and protein levels in WRO cells were detected by qRT-PCR and western blot. The phosphorylation levels of Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3) and the apoptosis-related protein levels of Bax, cleaved caspase 3 and Bcl-2 were assessed by western blot. Results Salidroside significantly suppressed migration/invasion and induced apoptosis in poorly differentiated thyroid cancer WRO cells. We further illustrated that salidroside significantly inhibited expressions of MMP2 and MMP9 at mRNA and protein levels and the phosphorylation activation of JAK2/STAT3 in WRO cells. In addition, salidroside increased expressions of pro-apoptotic factors (Bax and cleaved caspase 3) and decreased expression of anti-apoptotic factor (Bcl-2) significantly in WRO cells. Conclusion The present study demonstrates that salidroside inhibits migration and invasion of WRO cells (a kind of poorly differentiated cancer cell line) significantly, which might be via suppressing JAK2-STAT3 signaling pathway.
C1 [Shang, Hongxia; Yao, Jinming; Guo, Congcong; Liao, Lin] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Med, Div Endocrinol, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.
   [Wang, Shengnan] Shandong First Med Univ, Hosp Affiliated 1, Shandong Prov Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
   [Dong, Jianjun] Shandong Univ, Dept Med, Div Endocrinol, Qilu Hosp, 107 Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Liao, L (corresponding author), Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Med, Div Endocrinol, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.; Dong, JJ (corresponding author), Shandong Univ, Dept Med, Div Endocrinol, Qilu Hosp, 107 Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
EM cwc_ll@sdu.edu.cn; liaolin@sdu.edu.cn
FU National Natural Science Foundation of China [81070637, 81570742]
FX This work was funded by National Natural Science Foundation of China
   (81070637, 81570742).
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NR 40
TC 18
Z9 21
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1759-7706
EI 1759-7714
J9 THORAC CANCER
JI Thorac. Cancer
PD JUN
PY 2019
VL 10
IS 6
BP 1469
EP 1478
DI 10.1111/1759-7714.13096
PG 10
WC Oncology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Respiratory System
GA IK9HG
UT WOS:000476905200018
PM 31120636
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, P
   Li, YM
   Guo, R
   Zang, WF
AF Zhang, Peng
   Li, Yuanmin
   Guo, Rong
   Zang, Wangfu
TI Salidroside Protects Against Advanced Glycation End Products-Induced
   Vascular Endothelial Dysfunction
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Diabetes Mellitus, Type 2; Endothelial Cells; Glycosylation End
   Products, Advanced
ID NF-KAPPA-B; OXIDATIVE STRESS; ACTIVATION; PATHOLOGY
AB Background: Salidroside, the major active compound in Rhodiola, has been reported to provide beneficial effects on cardiovascular diseases, but its effects on diabetes-induced vascular endothelial dysfunction are less known. Here, we examined the protective effects of salidroside on endothelial function in diabetes and explored the potential underlying mechanism.
   Material/Methods: First, we assessed the endothelium-dependent relaxation response to acetylcholine, with or without salidroside treatment, in aortas isolated from Sprague-Dawley rats. Then, cell viability, oxidative biomarkers, and protein expression were tested to determine the effect of salidroside treatment on human umbilical vein endothelial cells (HUVECs) in vitro.
   Results: Advanced glycation end product (AGE)-induced endothelial dysfunction was significantly improved by salidroside treatment (P<0.05), as shown by a reduced relaxation response to the vasodilator acetylcholine. Further, incubation with salidroside restored NO levels and reduced reactive oxygen species formation in AGE-stimulated HUVECs in a concentration-dependent manner (P<0.05). We also showed that nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) and nuclear factor kappa B (NF-kappa B) signaling was critical for the salidroside-mediated beneficial regulation.
   Conclusions: Our results demonstrate that salidroside protects against AGE-induced endothelial dysfunction, and its effects may be in part attributed to the induction of HO-1 and attenuation of phosphorylated NF-kappa B p65.
C1 [Zhang, Peng; Li, Yuanmin; Zang, Wangfu] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiothorac Surg, Shanghai, Peoples R China.
   [Guo, Rong] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai, Peoples R China.
C3 Tongji University; Tongji University
RP Zang, WF (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiothorac Surg, Shanghai, Peoples R China.; Guo, R (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai, Peoples R China.
EM doctorguorong@aliyun.com; zangwf@hotmail.com
OI Guo, Rong/0000-0003-1323-5450
FU Science Foundation for The Excellent Youth Scholars of Tongji University
   [2016KJ052]
FX This study was supported by Science Foundation for The Excellent Youth
   Scholars of Tongji University (Grant No. 2016KJ052)
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NR 32
TC 22
Z9 23
U1 0
U2 25
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD APR 21
PY 2018
VL 24
DI 10.12659/MSM.906064
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GD9WW
UT WOS:000430864700002
PM 29679467
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Huang, XZ
   Xue, HY
   Ma, JY
   Zhang, YZ
   Zhang, J
   Liu, Y
   Qin, XG
   Sun, C
AF Huang, Xinzhong
   Xue, Haiyan
   Ma, Jinyu
   Zhang, Yunzhong
   Zhang, Jing
   Liu, Yue
   Qin, Xiaogang
   Sun, Cheng
TI Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting
   β-catenin activity
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE Adriamycin nephropathy; podocytes; salidroside; beta-catenin
ID IMPROVES GLUCOSE-HOMEOSTASIS; PODOCYTE INJURY; DIABETIC-NEPHROPATHY;
   ACTIVATION; PATHOGENESIS; ALBUMINURIA; PROTEINURIA; DYSFUNCTION;
   PATHWAY; DISEASE
AB Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrastinduced-nephropathy and other kidney diseases. However, the involved molecular mechanism was still not understood well. Herein, we examined the protective effects of salidroside in mice with Adriamycin (ADR)-induced nephropathy and the underlying molecular mechanism. The results showed that salidroside treatment ameliorates proteinuria; improves expressions of nephrin and podocin; and reduces kidney fibrosis and glomerulosclerosis induced by ADR. Mechanistically, ADR induces a robust accumulation of beta-catenin in the nucleus and stimulates its downstream target gene expression. The application of salidroside largely abolishes the nuclear translocation of beta-catenin and thus inhibits its activity. Furthermore, the activation of beta-catenin almost completely counteracts the protective roles of salidroside in ADR-injured podocytes. Taken together, our data indicate that salidroside ameliorates proteinuria, renal fibrosis and podocyte injury in ADR nephropathy, which may rely on inhibition of beta-catenin signalling pathway.
C1 [Huang, Xinzhong; Xue, Haiyan] Nantong Univ, Affiliated Hosp, Dept Nephrol, Nantong, Peoples R China.
   [Ma, Jinyu; Zhang, Jing; Sun, Cheng] Nantong Univ, Key Lab Neuroregenerat Jiangsu Prov, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Ma, Jinyu; Zhang, Jing; Sun, Cheng] Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Zhang, Yunzhong] Nantong Univ, Sch Med, Nantong, Peoples R China.
   [Liu, Yue; Qin, Xiaogang] Tradit Chinese Med Hosp Tongzhou Dist, Dept Nephrol, Nantong, Peoples R China.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University
RP Sun, C (corresponding author), Nantong Univ, Key Lab Neuroregenerat Jiangsu Prov, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.; Sun, C (corresponding author), Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM suncheng1975@ntu.edu.cn
RI Sun, Cheng/M-8729-2017
OI Sun, Cheng/0000-0001-8411-4619
FU National Key Research and Development Program of China [2017YFA0701304];
   National Natural Science Foundation of China [81770841]; Health and
   Family Planning Commission research projects of Jiangsu [H201522];
   Science and Technology Foundation of Nantong [BK2013006]; Dr. Scientific
   Research Foundation of Nantong University [14B40]
FX National Key Research and Development Program of China, Grant/Award
   Number: 2017YFA0701304; National Natural Science Foundation of China,
   Grant/Award Number: 81770841; Health and Family Planning Commission
   research projects of Jiangsu, Grant/Award Number: H201522; Science and
   Technology Foundation of Nantong, Grant/Award Number: BK2013006; Dr.
   Scientific Research Foundation of Nantong University, Grant/Award
   Number: 14B40
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NR 46
TC 21
Z9 24
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUN
PY 2019
VL 23
IS 6
BP 4443
EP 4453
DI 10.1111/jcmm.14340
PG 11
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA IC0OL
UT WOS:000470659500058
PM 30993911
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhen, LL
   Hou, MT
   Wang, SB
AF Zhen, Ling-Ling
   Hou, Ming-Tong
   Wang, Sheng-Bao
TI Salidroside attenuates sepsis-induced acute kidney injury by inhibiting
   ferroptosis
SO JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
LA English
DT Article
DE Sepsis; acute kidney injury; salidroside; ferroptosis; arachidonic acid
ID OXIDATIVE STRESS; MECHANISMS
AB Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).
C1 [Zhen, Ling-Ling] Lanzhou Univ, Hosp 2, Lanzhou 730030, Peoples R China.
   [Hou, Ming-Tong] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730030, Peoples R China.
   [Wang, Sheng-Bao] Lanzhou Univ, Hosp 2, Emergency Ctr, Lanzhou 730030, Peoples R China.
C3 Lanzhou University; Lanzhou University; Lanzhou University
RP Wang, SB (corresponding author), Lanzhou Univ, Hosp 2, Emergency Ctr, Lanzhou 730030, Peoples R China.
EM wangshengbao@lzu.edu.cn
FU Second Hospital of Lanzhou University "Cuiying Science and Technology
   Innovation" Program [CY2020-MS06]; Natural Science Foundation of Gansu
   Province [20JR10RA724]; Lanzhou Science and Technology Development
   Program Project [2020-ZD-91]
FX This work was financially supported by The Second Hospital of Lanzhou
   University "Cuiying Science and Technology Innovation" Program
   (No.CY2020-MS06), Natural Science Foundation of Gansu Province
   (No.20JR10RA724) and Lanzhou Science and Technology Development Program
   Project (No.2020-ZD-91).
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NR 30
TC 0
Z9 0
U1 2
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-6020
EI 1477-2213
J9 J ASIAN NAT PROD RES
JI J. Asian Nat. Prod. Res.
PD JAN 2
PY 2026
VL 28
IS 1
BP 142
EP 156
DI 10.1080/10286020.2025.2481291
EA APR 2025
PG 15
WC Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Pharmacology & Pharmacy
GA AO9SO
UT WOS:001458040300001
PM 40171644
DA 2026-05-27
ER

PT J
AU Zeng, WZ
   Wang, HJ
   Chen, JB
   Hu, ML
   Wang, XR
   Chen, J
   Zhou, JW
AF Zeng, Weizhu
   Wang, Huijing
   Chen, Jianbin
   Hu, Minglong
   Wang, Xinru
   Chen, Jian
   Zhou, Jingwen
TI Engineering Escherichia coli for Efficient De Novo Synthesis of
   Salidroside
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE tyrosol; adaptive evolution; glycosylation; semirational design;
   fermentation optimization
ID OPTIMIZATION; PATHWAY
AB Salidroside is a high-value plant-derived glycoside with diverse biological activities, but the main industrial salidroside production method, extraction from Rhodiola plants, is insufficient to meet the growing market demand. The biosynthetic route via microbial fermentation is a sustainable and eco-friendly alternative method. De novo synthesis of the precursor tyrosol was established by introducing the ARO10 and ADH6 genes. Systematic metabolic engineering resulted in 3.0 g/L tyrosol, but accumulated tyrosol inhibited cell growth. Adaptive evolution produced an evolved strain with a 10.0% higher OD600 and a 3.3 g/L tyrosol titer. Introducing glucosyltransferase AtUGT85A1, and overexpressing phosphoglucose mutase pgm and UDP-glucose pyrophosphorylase galU, achieved de novo synthesis of salidroside. Furthermore, AtUGT85A1 was semirationally engineered, resulting in the A21G mutation, which enhanced salidroside production by 31.2%. The optimally engineered strain produced 16.8 g/L salidroside with 0.4 g/(L h) productivity in a 5 L bioreactor. This study laid a foundation for future industrial production of salidroside and provided important guidance for efficient biosynthesis of other tyrosol derivatives.
C1 [Zeng, Weizhu; Wang, Huijing; Chen, Jianbin; Hu, Minglong; Wang, Xinru; Chen, Jian; Zhou, Jingwen] Jiangnan Univ, Engn Res Ctr, Minist Educ Food Synthet Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zeng, Weizhu; Wang, Huijing; Chen, Jianbin; Hu, Minglong; Wang, Xinru; Chen, Jian; Zhou, Jingwen] Jiangnan Univ, Sci Ctr Future Foods, Wuxi 214122, Jiangsu, Peoples R China.
   [Wang, Huijing; Chen, Jianbin; Hu, Minglong; Wang, Xinru; Chen, Jian; Zhou, Jingwen] Jiangnan Univ, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.
   [Wang, Huijing; Chen, Jianbin; Hu, Minglong; Wang, Xinru; Chen, Jian; Zhou, Jingwen] Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zeng, Weizhu; Chen, Jian; Zhou, Jingwen] Jiangnan Univ, Jiangsu Prov Engn Res Ctr Food Synthet Biotechnol, Wuxi 214122, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan
   University; Jiangnan University
RP Zhou, JW (corresponding author), Jiangnan Univ, Engn Res Ctr, Minist Educ Food Synthet Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.; Zhou, JW (corresponding author), Jiangnan Univ, Sci Ctr Future Foods, Wuxi 214122, Jiangsu, Peoples R China.; Zhou, JW (corresponding author), Jiangnan Univ, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.; Zhou, JW (corresponding author), Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.; Zhou, JW (corresponding author), Jiangnan Univ, Jiangsu Prov Engn Res Ctr Food Synthet Biotechnol, Wuxi 214122, Peoples R China.
EM zhoujw1982@jiangnan.edu.cn
RI ; Wang, Xinru/AAR-1510-2021; Zhou, Jingwen/A-4982-2008; Chen,
   Jianbin/HGF-1513-2022
OI Zeng, Weizhu/0000-0003-2456-7426; 
FU the National Key Research and Development Program of China
   [2024YFF1106400]; National Key Research and Development Program of China
   [32021005]; Foundation for Innovative Research Groups of the National
   Natural Science Foundation of China
FX This work was supported by the National Key Research and Development
   Program of China (2024YFF1106400) and the Foundation for Innovative
   Research Groups of the National Natural Science Foundation of China
   (32021005).
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NR 51
TC 23
Z9 27
U1 23
U2 92
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD DEC 12
PY 2024
VL 72
IS 51
BP 28369
EP 28377
DI 10.1021/acs.jafc.4c10247
EA DEC 2024
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA Q2O9T
UT WOS:001376031800001
PM 39666864
DA 2026-05-27
ER

PT J
AU Hu, XM
   Li, Y
   Wang, F
   Tian, YJ
   Ye, YQ
   Zhang, JX
   Guo, HY
   He, RX
   Li, HX
   Wang, ZP
AF Hu, Xuemei
   Li, Yi
   Wang, Fang
   Tian, Yuejun
   Ye, Yingqin
   Zhang, Jixue
   Guo, Hongyu
   He, Rongxia
   Li, Huixin
   Wang, Zhiping
TI Salidroside induces cell cycle arrest and apoptosis in human cervical
   cancer SiHa cells
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Salidroside; cell cycling; apoptosis; cervical cancer SiHa cells
ID EXPRESSION; INJURY; RISK; DRUG; FAS
AB Background: Salidroside has potent anti-oxidant, anti-inflammation and anti-tumor activity. However, little is known regarding its effect on cervical cancer cells. This study investigated the effect of different concentrations of salidroside on the viability, cell cycling and apoptosis of cervical cancer SiHa cells and its potential mechanisms. Methods: Cell growth potential was measured by Cell Counting Kit-8 assay and colony formation. Cell cycle distribution was measured by flow cytometry. A light microscope was used to detect the morphology of SiHa cells. Western blot was used to measure the protein expression of the indicated genes. Results: Treatment with different concentrations of salidroside significantly reduced the viability of SiHa cells in a dose-and time-dependent manner. Treatment with salidroside resulted in morphological changes in SiHa cells and induced cell cycle arrest at the G2/M and/or S phase, which was associated with significantly decreased levels of Cyclin B1, Cyclin A and Cyclin-dependent kinase-2 expression but up-regulating P21 expression. Furthermore, treatment with different concentrations of salidroside induced the apoptosis of SiHa cells, and their effects were dose-dependent. Finally, treatment with salidroside enhanced the relative levels of cleaved caspase 3, Bax, and Fas expression but down-regulated the relative levels of BcL-2 and FasL expression in SiHa cells. These results demonstrated that salidroside had potent cytotoxicity against SiHa cells by inducing cell cycle arrest and apoptosis in cervical cancer. Salidroside may be a promising candidate for cervical cancer chemotherapy.
C1 [Hu, Xuemei; Wang, Fang; Tian, Yuejun; Guo, Hongyu; He, Rongxia] Lanzhou Univ, Hosp 2, Dept Gynecol & Obstet, Lanzhou, Peoples R China.
   [Tian, Yuejun; Wang, Zhiping] Lanzhou Univ, Hosp 2, Key Lab Urol Dis, Lanzhou, Peoples R China.
   [Li, Yi] Gansu Tradit Chinese Med Univ, Inst Syst Biol & TCM Transformat, Lanzhou, Peoples R China.
   [Ye, Yingqin] Hlth Women & Child Hosp, Lanzhou, Peoples R China.
   [Li, Huixin] Zhoupus Hosp Pudong Dist, Dept Gynecol & Obstet, Shanghai, Peoples R China.
C3 Lanzhou University; Lanzhou University; Gansu University of Chinese
   Medicine
RP Li, HX (corresponding author), Zhoupus Hosp Pudong Dist, Dept Gynecol & Obstet, Shanghai, Peoples R China.; Wang, ZP (corresponding author), Lanzhou Univ, Hosp 2, Dept Urol, Lanzhou 730030, Peoples R China.
EM lihx14@163.com; wangzplzu@163.com
RI Hu, Xuemei/KOD-3202-2024
OI Tian, Yuejun/0000-0001-5798-8142
FU Traditional Chinese Medicine Scientific Research Funds of Health and
   Family Planning Committee of Shanghai [2014.JP024A]
FX This study was supported by a grant from the Traditional Chinese
   Medicine Scientific Research Funds of Health and Family Planning
   Committee of Shanghai, (number: 2014.JP024A).
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NR 29
TC 3
Z9 3
U1 0
U2 13
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 4
BP 6351
EP 6359
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ET8MJ
UT WOS:000400553200049
DA 2026-05-27
ER

PT J
AU Xu, JS
   Li, Y
AF Xu, Jiansheng
   Li, Ying
TI Effects of salidroside on exhaustive exercise-induced oxidative stress
   in rats
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; exhaustive exercise; oxidative stress; rats
ID IN-VITRO; ANTIOXIDANT ACTIVITY; CARBOHYDRATE INTAKE; PHYSICAL-EXERCISE;
   DNA-DAMAGE; MICE; SUPPLEMENTATION; CAPACITY; RECOVERY; RUNNERS
AB Intense exercise increases oxygen consumption and may produce an imbalance between reactive oxygen species (ROS) and antioxidants, inducing oxidative stress as a result of increased ROS production. Exogenous antioxidants may prevent oxidative damages since they are able to detoxify certain peroxides by scavenging the ROS produced during exercise. The aim of this study was to evaluate the effects of salidroside on exhaustive exercise-induced oxidative stress in rats. A total of 40 animals were randomly divided into four groups of ten rats each: control (C), low-dose salidroside-treated (LT), middle-dose salidroside-treated (MT) and high-dose salidroside-treated (HT) groups. The rats in the treated groups received salidroside (25, 50 and 100 mg/kg, respectively) intragastrically (ig) and the rats in the control group received drinking water ig for 4 weeks. After 4 weeks, the rats performed an exhaustive swimming exercise and exhaustive swimming times were recorded. The malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glycogen levels in the liver tissues of the rats were measured. The data revealed that salidroside was able to elevate the exercise tolerance and increase the liver glycogen levels of the rats following exhaustive exercise. Salidroside was also able to reduce MDA levels and enhance the activities of antioxidant enzymes (CAT, SOD and GSH-Px) in the liver tissues of the rats. The results from this study indicate that salidroside is effective in the prevention of oxidative stress following exhaustive exercise.
C1 [Xu, Jiansheng] Tianjin Univ, Dept Phys Educ, Tianjin 300072, Peoples R China.
   [Li, Ying] Tianjin Agr Univ, Dept Phys Educ, Tianjin 300084, Peoples R China.
C3 Tianjin University; Tianjin Agricultural University
RP Xu, JS (corresponding author), Tianjin Univ, Dept Phys Educ, 92 Weijin Rd, Tianjin 300072, Peoples R China.
EM jishxu@163.com
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NR 31
TC 50
Z9 61
U1 0
U2 19
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD NOV
PY 2012
VL 6
IS 5
BP 1195
EP 1198
DI 10.3892/mmr.2012.1060
PG 4
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 023MN
UT WOS:000310039200048
PM 22948446
OA Bronze
DA 2026-05-27
ER

PT J
AU Sun, SY
   Tuo, QH
   Li, DX
   Wang, XL
   Li, XF
   Zhang, YY
   Zhao, G
   Lin, F
AF Sun, Siyu
   Tuo, Qinhui
   Li, Dongxu
   Wang, Xiulong
   Li, Xuefang
   Zhang, Yiyue
   Zhao, Guoan
   Lin, Fei
TI Antioxidant Effects of Salidroside in the Cardiovascular System
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID PEROXIDE-INDUCED INJURY; RHODIOLA-ROSEA L.; OXIDATIVE STRESS; IN-VITRO;
   ISCHEMIA/REPERFUSION INJURY; PULMONARY-HYPERTENSION; ENDOTHELIAL-CELLS;
   MYOCARDIAL INJURY; PROTECTS; DYSFUNCTION
AB Cardiovascular disease is one of the main human health risks, and the incidence is increasing. Salidroside is an important bioactive component of Rhodiola rosea L., which is used to treat Alzheimer's disease, tumor, depression, and other diseases. Recent studies have shown that salidroside has therapeutic effects, to some degree, in cardiovascular diseases via an antioxidative mechanism. However, evidence-based clinical data supporting the effectiveness of salidroside in the treatment of cardiovascular diseases are limited. In this review, we discuss the effects of salidroside on cardiovascular risk factors and cardiovascular diseases and highlight potential antioxidant therapeutic strategies.
C1 [Sun, Siyu; Li, Dongxu; Wang, Xiulong; Li, Xuefang; Zhang, Yiyue; Zhao, Guoan; Lin, Fei] Xinxiang Med Univ, Affiliated Hosp 1, Cardiovasc Res Ctr, Xinxiang 453003, Henan, Peoples R China.
   [Tuo, Qinhui] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.
C3 Henan Medical University; Hunan University of Chinese Medicine
RP Lin, F (corresponding author), Xinxiang Med Univ, Affiliated Hosp 1, Cardiovasc Res Ctr, Xinxiang 453003, Henan, Peoples R China.
EM linfeixixi@aliyun.com
RI LI, DONGXU/GNM-6998-2022
FU National Natural Science Foundation of China [81503421, 81673722];
   Special Funds for Funding Funds of Fundamental Research Business Fees of
   Central Public Welfare Research Institutions [JDZX2015248]; Key
   Scientific Research Projects of Higher Education Institutions in Henan
   Province [18A320005, 19A360032]; Young Elite Scientists Sponsorship
   Program by CAST [2017QNRC001]
FX This study was supported by the National Natural Science Foundation of
   China (nos. 81503421 and 81673722), Special Funds for Funding Funds of
   Fundamental Research Business Fees of Central Public Welfare Research
   Institutions (no. JDZX2015248), Key Scientific Research Projects of
   Higher Education Institutions in Henan Province (nos. 18A320005 and
   19A360032), and Young Elite Scientists Sponsorship Program by CAST
   (YESS, 2017QNRC001).
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NR 86
TC 58
Z9 62
U1 5
U2 54
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD SEP 26
PY 2020
VL 2020
AR 9568647
DI 10.1155/2020/9568647
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OB2FO
UT WOS:000578289300001
PM 33062029
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Ariyanti, AD
   Zhang, JQ
   Marcelina, O
   Nugrahaningrum, DA
   Wang, G
   Kasim, V
   Wu, SR
AF Ariyanti, Agnes Dwi
   Zhang, Jianqi
   Marcelina, Olivia
   Nugrahaningrum, Dyah Ari
   Wang, Guixue
   Kasim, Vivi
   Wu, Shourong
TI Salidroside-Pretreated Mesenchymal Stem Cells Enhance Diabetic Wound
   Healing by Promoting Paracrine Function and Survival of Mesenchymal Stem
   Cells Under Hyperglycemia
SO STEM CELLS TRANSLATIONAL MEDICINE
LA English
DT Article
DE Tissue regeneration; Mesenchymal stem cells; Cell transplantation;
   Diabetes; Cell migration
ID HEPATOCYTE GROWTH-FACTOR; REGULATING HEME OXYGENASE-1;
   ENDOTHELIAL-CELLS; OXIDATIVE STRESS; EXPRESSION; MIGRATION; INCREASES;
   NEOVASCULARIZATION; PROLIFERATION; ANGIOGENESIS
AB Systemic abnormalities cause several complications in diabetes patients. Impaired wound healing is a serious complication that leads to severe foot ulcer and amputation. Mesenchymal stem cells (MSCs) have been considered a promising strategy for promoting wound healing due to their paracrine function. However, their poor survival after transplantation limits their therapeutic effect and applications. Salidroside, a glucopyranoside, has been reported to exert cytoprotective effects. Our previous study revealed that salidroside could promote the paracrine function of skeletal muscle cells. However, whether salidroside could improve MSCs survival under hyperglycemic condition and, subsequently, promote wound healing in diabetic model mice remains unknown. Here, we found that salidroside pretreatment effectively reversed the hyperglycemia-induced suppression of the expression of crucial wound healing factors in MSCs, such as heme oxygenase-1 (HO-1), fibroblast growth factor 2 (FGF2), and hepatocyte growth factor (HGF). Salidroside pretreatment also suppressed the hyperglycemia-induced intracellular reactive oxygen species (ROS) levels in MSCs, thereby lowering the apoptosis rate and enhancing MSCs survival rate. Furthermore, salidroside improved the MSCs migration potential that was impaired under hyperglycemia. in vivo experiments revealed that salidroside pretreatment prior to transplantation significantly enhanced the effect of MSCs in promoting wound closure in diabetic mice. Collectively, our results suggest that pretreatment with salidroside could be an effective strategy to enhance the survival rate and the therapeutic effect of MSCs. Thus, our article suggested a novel, potential MSC-based strategy for diabetic wound healing. Stem Cells Translational Medicine 2019;8:404-414
C1 [Ariyanti, Agnes Dwi; Zhang, Jianqi; Marcelina, Olivia; Nugrahaningrum, Dyah Ari; Wang, Guixue; Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing, Peoples R China.
   [Ariyanti, Agnes Dwi; Zhang, Jianqi; Marcelina, Olivia; Nugrahaningrum, Dyah Ari; Wang, Guixue; Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, State & Local Joint Engn Lab Vasc Implants, Chongqing, Peoples R China.
   [Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing, Peoples R China.
C3 Chongqing University; Chongqing University; Chongqing University
RP Kasim, V; Wu, SR (corresponding author), Chongqing Univ, Coll Bioengn, 174 Shazheng St, Chongqing, Peoples R China.
EM vivikasim@cqu.edu.cn; shourongwu@cqu.edu.cn
RI ; Wang, Guixue/ACN-6343-2022; Kasim, Vivi/AID-0964-2022
OI Kasim, Vivi/0000-0001-9182-8230; Marcelina, Olivia/0000-0003-0941-3314; 
FU National Natural Science Foundation of China [81372202, 81872273,
   31871367]; State and Local Joint Engineering Laboratory for Vascular
   Implants (Chongqing)
FX This work was supported by grants from the National Natural Science
   Foundation of China Nos. 81372202, 81872273, and 31871367. We also thank
   the support from the State and Local Joint Engineering Laboratory for
   Vascular Implants (Chongqing).
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NR 42
TC 64
Z9 78
U1 1
U2 59
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2157-6564
EI 2157-6580
J9 STEM CELL TRANSL MED
JI Stem Cells Transl. Med.
PD APR
PY 2019
VL 8
IS 4
BP 404
EP 414
DI 10.1002/sctm.18-0143
PG 11
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HQ1LG
UT WOS:000462158700012
PM 30624028
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Qi, SS
   Shao, ML
   Ze, S
   Zheng, HX
AF Qi, Shan Shan
   Shao, Meng Li
   Ze, Sun
   Zheng, Hong Xing
TI Salidroside from Rhodiola rosea L. attenuates diabetic
   nephropathy in STZ induced diabetic rats via anti-oxidative stress,
   anti-inflammation, and inhibiting TGF-β1/Smad pathway
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Salidroside; Diabetes; Renal pathology; Fibrosis
AB Salidroside from Rhodiola rosea L. has hypoglycemic effects, and has anti-osteoporosis effect in diabetic rats. Whether it has beneficial effects on diabetic nephropathy (DN) has not been fully reported. Here, a DN rat model was established by streptozotocin (STZ). Salidroside (10, and 20 mg kg(-1) d(-1)) were orally giving for eight weeks. The purity of salidroside was 99%. The results showed that eight weeks salidroside supplementation dosedependently decreased blood glucose, serum insulin, serum creatinine, blood urea nitrogen (BUN), as well as urinary albumin of DN rats, repaired the pathological changes of kidney tissue, the renal sclerosis and fibrosis in the kidney of DN rats were improved, and the activities of oxidative defense system associated enzyme such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were also improved. Serum inflammatory cytokines (including tumor necrosis factor-alpha, monocyte chemoattractant protein-1, interleukin-18, and interleukin-6) were decreased significantly in DN rats after eight weeks salidroside supplementation. Immunohistochemical results showed that fibrosis related proteins such as transforming growth factor-beta 1 (TGF-beta 1), phospho-Smad2 (p-Smad2), and phospho-Smad3 (p-Smad3) expression levels were decreased significantly in the kidney of salidroside treated group. Our results indicate that daily salidroside consumption could alleviate DN in rats, the main mechanisms are anti-inflammatory, anti-oxidative stress, and inhibition of the TGF-beta 1/Smad2/3 pathway. This study suggested that salidroside could be used as a nutrient against DN, as well as diabetes.
C1 [Qi, Shan Shan] Shaanxi Univ Technol, Vitamin D Res Inst, Coll Biol Sci & Engn, Hanzhong, Peoples R China.
   [Shao, Meng Li; Ze, Sun; Zheng, Hong Xing] Shaanxi Univ Technol, Coll Biol Sci & Engn, Hanzhong, Peoples R China.
C3 Shaanxi University of Technology; Shaanxi University of Technology
RP Qi, SS (corresponding author), Shaanxi Univ Technol, Vitamin D Res Inst, Coll Biol Sci & Engn, Hanzhong, Peoples R China.; Zheng, HX (corresponding author), Shaanxi Univ Technol, Coll Biol Sci & Engn, Hanzhong, Peoples R China.
EM qishanshan@snut.edu.cn; zhenghongxing@snut.edu.cn
RI Qi, Shanshan/IVU-8388-2023; /D-7472-2011
FU Natural Science Project of Shaanxi Science and Technology Department
   [2020JM-601]; Key research project of Education Department of Shaanxi
   Province [20JY005]; open project of Shaanxi Provincial Key Laboratory of
   Resource Biology [SLGPT2019KF03-06]; Key Laboratory of Se-enriched
   Products Development and Quality Control, Ministry of Agriculture and
   Rural Affairs/National-Local Joint Engineering Laboratory of Se-enriched
   Food Development [Se-2020C05]
FX This research was funded by the Natural Science Project of Shaanxi
   Science and Technology Department (2020JM-601), the Key research project
   of Education Department of Shaanxi Province (20JY005), the open project
   of Shaanxi Provincial Key Laboratory of Resource Biology
   (SLGPT2019KF03-06), and the Key Laboratory of Se-enriched Products
   Development and Quality Control, Ministry of Agriculture and Rural
   Affairs/National-Local Joint Engineering Laboratory of Se-enriched Food
   Development (Se-2020C05).
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NR 50
TC 17
Z9 18
U1 1
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2021
VL 77
AR 104329
DI 10.1016/j.jff.2020.104329
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA QB9RK
UT WOS:000614472600003
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, GS
   Yi, SY
   Wang, HJ
   Qiu, HL
   Wang, W
   Gao, LL
   Xu, QL
   Han, BX
   Yin, XJ
AF Li, Guosi
   Yi, Shanyong
   Wang, Haijiao
   Qiu, Hulin
   Wang, Wei
   Gao, Leilei
   Xu, Qilin
   Han, Bangxing
   Yin, Xinjian
TI Salidroside production through cascade biocatalysis with a
   thermostability-enhanced UDP-glycosyltransferase
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Cascade biocatalysis; Computational engineering; Thermal stability;
   UDP-glycosyltransferase; Salidroside
ID CYCLODEXTRIN GLYCOSYLTRANSFERASE; ENZYMATIC-SYNTHESIS; BIOSYNTHESIS;
   STABILITY; DESIGN; GENOME; ENERGY
AB Salidroside is a phenylpropanoid glycoside with wide applications in the food, pharmaceutical, and cosmetic industries; however, the plant genus Rhodiola, the natural source of salidroside, has slow growth and limited distribution. In this study, we designed a novel six-enzyme biocatalytic cascade for the efficient production of salidroside, utilizing cost-effective bio-based L-Tyrosine as the starting material. A preliminary analysis revealed that the poor thermostability of the Bacillus licheniformis UDP-glycosyltransferase (EC 2.4.1.384) Bl YjiC M6 is a bottleneck in the cascade. Therefore, a combined computational strategy was used to engineer it and finally obtained a mutant TSM6(T304V/G307A/N309W/F123W/T344V/D271G) with a 134-fold longer half-life at 40 degrees C and a 13 degrees C higher T m app compared to M6. The integration of TSM6 into the cascade improved salidroside productivity significantly, while reducing residual intermediates. After further optimization, the whole-cell biocatalytic cascade achieved a high salidroside titer of 12.8 g center dot L-1 in a 5 L bioreactor, giving a productivity of 0.53 g center dot L- 1 center dot h- 1 . This study provides a green and efficient biosynthetic process for salidroside production and highlights the potential of enzyme engineering to enhance the biocatalytic cascade.
C1 [Li, Guosi; Yi, Shanyong; Wang, Wei; Gao, Leilei; Xu, Qilin; Han, Bangxing] West Anhui Univ, Tradit Chinese Med Inst Anhui Dabie Mt, Gener Technol Res Ctr Anhui Tradit Chinese Med Ind, Anhui Engn Res Ctr Ecoagr Tradit Chinese Med, Luan 237012, Anhui, Peoples R China.
   [Wang, Haijiao] Chinese Acad Sci, Key State Lab Plant Divers & Specialty Crops, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Peoples R China.
   [Qiu, Hulin; Yin, Xinjian] Sun Yat Sen Univ, Sch Marine Sci, Zhuhai 519080, Peoples R China.
C3 West Anhui University; Chinese Academy of Sciences; South China
   Botanical Garden, CAS; Sun Yat Sen University
RP Han, BX (corresponding author), West Anhui Univ, Tradit Chinese Med Inst Anhui Dabie Mt, Gener Technol Res Ctr Anhui Tradit Chinese Med Ind, Anhui Engn Res Ctr Ecoagr Tradit Chinese Med, Luan 237012, Anhui, Peoples R China.; Yin, XJ (corresponding author), Sun Yat Sen Univ, Sch Marine Sci, Zhuhai 519080, Peoples R China.
EM hanbx1978@sina.com; yinxj5@mail.sysu.edu.cn
RI Xu, Qilin/JDD-9383-2023
FU Natural Science Foundation of Higher Education Institutions of Anhui
   Province [2023AH052649]; Fund of Generic Technology Research Centre for
   Anhui Traditional Chinese Medicine Industry [AHTCMGTRC-2023-09]
FX This work was financially supported by the National Key Research and
   Development Program of China (2023YFC3503804) , National Natural Science
   Foundation of China (No. 22108317; No. 82304679) ,r Natural Science
   Foundation of Higher Education Institutions of Anhui Province
   (2023AH052649) , and Fund of Generic Technology Research Centre for
   Anhui Traditional Chinese Medicine Industry (AHTCMGTRC-2023-09) .
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NR 51
TC 7
Z9 7
U1 22
U2 70
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD APR
PY 2025
VL 299
AR 140261
DI 10.1016/j.ijbiomac.2025.140261
EA JAN 2025
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA U1W6K
UT WOS:001409785900001
PM 39855494
DA 2026-05-27
ER

PT J
AU Xiong, YL
   Wang, YM
   Xiong, YL
   Teng, LH
AF Xiong, Yanlei
   Wang, Yueming
   Xiong, Yanlian
   Teng, Lianghong
TI Protective effect of Salidroside on hypoxia-related liver oxidative
   stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE hypoxia; inflammation; liver; oxidative stress; salidroside
ID INJURY; CYTOKINES; ROLES
AB High-altitude hypoxia-induced oxidative stress and inflammation played an essential role in the incidence and development of liver injury. Salidroside (Sal), a phenylpropanoid glycoside extracted from the plant Rhodiola rosea, has recently demonstrated antioxidant, anti-inflammatory, and antihypoxia properties. Herein, we hypothesized that salidroside may alleviate hypoxia-induced liver injury via antioxidant and antiinflammatory-related pathways. A high-altitude hypoxia animal model was established using hypobaric chamber. Male SD rats were randomly divided into the control group, hypoxia group, control +Sal group, and hypoxia +Sal group. Salidroside treatment significantly inhibited hypoxia-induced increases of serum and hepatic pro-inflammatory cytokines release, hepatic ROS production and MDA contents; attenuated hypoxia-induced decrease of hepatic SOD, CAT, and GSH-Px activities. Furthermore, salidroside treatment also potentiated the activation of Nrf2-mediated anti-oxidant pathway, as indicated by upregulation of n-Nrf2 and its downstream HO-1 and NQO-1. In vitro study found that blocking the Nrf2 pathway using specific inhibitor ML385 significantly reversed the protective effect of salidroside on hypoxia-induced liver oxidative stress. In addition, salidroside treatment significantly inhibited hepatic pro-inflammatory cytokines release via JAK2/STAT3-mediated pathway. Taken together, our findings suggested that salidroside protected against hypoxia-induced hepatic oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways.
C1 [Xiong, Yanlei; Teng, Lianghong] Capital Med Univ, Xuanwu Hosp, Dept Pathol, 45 Changchun St, Beijing 100053, Peoples R China.
   [Xiong, Yanlei] Chinese Acad Med Sci CAMS, Dept Pathophysiol Inst Basic Med Sci, Sch Basic Med, Peking Union Med Coll PUMC, Beijing, Peoples R China.
   [Wang, Yueming; Xiong, Yanlian] Binzhou Med Univ, Sch Basic Med, Dept Anat, Yantai, Peoples R China.
C3 Capital Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College; Shandong Medical &
   Pharmaceutical University
RP Teng, LH (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Pathol, 45 Changchun St, Beijing 100053, Peoples R China.
EM tenglianghong@163.com
FU National Natural Science Foundation of China [81700760]; Natural Science
   Foundation of Shandong Province [ZR2018QH002]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 81700760) and Natural Science Foundation of Shandong
   Province (grant number ZR2018QH002).
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NR 38
TC 49
Z9 58
U1 10
U2 85
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD SEP
PY 2021
VL 9
IS 9
BP 5060
EP 5069
DI 10.1002/fsn3.2459
EA JUL 2021
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UQ1FU
UT WOS:000671543500001
PM 34532015
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, X
   Zhao, JF
   Zhao, F
   Yan, JF
   Yang, F
   Huang, XJ
   Chen, G
   Fu, HY
   Lv, BD
AF Zhang, Xiang
   Zhao, Jian-feng
   Zhao, Fan
   Yan, Jun-feng
   Yang, Fan
   Huang, Xiao-jun
   Chen, Gang
   Fu, Hui-ying
   Lv, Bo-dong
TI The Protective Effect of Salidroside on Hypoxia-Induced Corpus
   Cavernosum Smooth Muscle Cell Phenotypic Transformation
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ERECTILE DYSFUNCTION; CURRENT INFORMATION; PENILE FIBROSIS; ACTIVATION;
   TISSUE; MODEL
AB Salidroside, a major active ingredient isolated from Rhodiola rosea, has a long application in Chinese medical history. It has widely demonstrated effects on fatigue, psychological stress, and depression and exhibits potential antihypoxia activity. Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED). The aim of this study was to clarify the effect of salidroside on hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells (CCSMCs). Our results showed that salidroside decreased the hypoxia-induced expression of collagen and content of vimentin, a corpus cavernosum smooth muscle synthetic protein, in vitro. Simultaneously, salidroside increased expression of the CCSMC contractile proteins,alpha-smoothmuscle actin (alpha-SMA) and desmin. In vivo, similarly, the expressions of collagen and hypoxia-inducible factor 1 alpha. were increased in bilateral cavernous neurectomy (BCN) rats while they were decreased in the salidroside group. Among the phenotypic proteins,alpha-SMA and desmin increased and vimentin decreased after treating BCN rats with salidroside compared with the BCN alone group. Overall, our results demonstrate that salidroside has the ability to oppose hypoxia and can inhibit the CCSMC phenotypic transformation induced by hypoxia. Salidroside may provide a new treatment method for ED.
C1 [Zhang, Xiang; Zhao, Fan; Yan, Jun-feng; Fu, Hui-ying] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China.
   [Zhao, Jian-feng; Huang, Xiao-jun; Chen, Gang; Lv, Bo-dong] Zhejiang Chinese Med Univ, Dept Urol, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
   [Yang, Fan] Zhejiang Univ, Childrens Hosp, Dept Urol, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Fu, Hui-ying; Lv, Bo-dong] Zhejiang Prov Key Lab Tradit Chinese Med, Androl Lab Integrat Chinese & Western Med, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang University
RP Fu, HY (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China.; Lv, BD (corresponding author), Zhejiang Chinese Med Univ, Dept Urol, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.; Fu, HY; Lv, BD (corresponding author), Zhejiang Prov Key Lab Tradit Chinese Med, Androl Lab Integrat Chinese & Western Med, Hangzhou, Zhejiang, Peoples R China.
EM fhy131@126.com; lbd168@126.com
RI ; Yang, Fan/AAA-6904-2022; fu, huiying/GZG-2399-2022
OI Zhang, Xiang/0000-0002-4239-0145; 
FU National Natural Science Foundation of China [81571431, 81603620];
   Zhejiang Provincial Natural Science Foundation of China [LY15H040010]
FX This work was supported by the National Natural Science Foundation of
   China [no. 81571431; no. 81603620] and the Zhejiang Provincial Natural
   Science Foundation of China [no. LY15H040010].
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NR 35
TC 11
Z9 14
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 3530281
DI 10.1155/2017/3530281
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FA7HG
UT WOS:000405615900001
PM 28798798
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Sun, C
   Wang, ZH
   Zheng, QS
   Zhang, H
AF Sun, Chao
   Wang, Zhenhua
   Zheng, Qiusheng
   Zhang, Hong
TI Salidroside inhibits migration and invasion of human fibrosarcoma HT1080
   cells
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; Invasion; Metastasis; HT1080 cells; Reactive oxygen species
ID ACTIVATED PROTEIN-KINASE; SIGNAL-REGULATED KINASE; INTEGRIN EXPRESSION;
   HYDROGEN-PEROXIDE; CANCER METASTASIS; OXIDATIVE STRESS; APOPTOSIS;
   MECHANISMS; RHODIOLA; OVARIAN
AB Oxidative stress plays an important role in tumorigenesis and metastasis. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L. shows potent antioxidant property. Here we investigated the inhibitory effects of salidroside on tumor metastasis in human fibrosarcoma HT1080 cells in vitro. The results indicated that salidroside significantly reduced wound closure areas of HT1080 cells, inhibited HT1080 cells invasion into Matrigel-coated membranes, suppressed matrix metalloproteinases (MMP-2 and MMP-9) activity, and increased tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in a dose-dependent manner in HT1080 cells. Salidroside treatment upregulated the E-cadherin expression, while downregulated the expression of beta 1-integrin. As an antioxidant, salidroside inhibited the intracellular reactive oxygen species (ROS) formation in a dose-dependent manner. The results also showed that salidroside could inhibit the activation of protein kinase C (PKC) and the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in a dose-dependent manner. In conclusion, these results suggest that salidroside inhibits tumor cells metastasis, which may due to its interfere in the intracellular excess ROS thereby down-regulated the ROS-PKC-ERK1/2 signaling pathway. (C) 2011 Elsevier GmbH. All rights reserved.
C1 [Sun, Chao; Wang, Zhenhua; Zhang, Hong] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Peoples R China.
   [Sun, Chao; Wang, Zhenhua; Zhang, Hong] Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China.
   [Sun, Chao] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China.
   [Wang, Zhenhua; Zheng, Qiusheng] Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Minist Educ, Sch Pharm, Shihezi, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Modern Physics, CAS; Chinese
   Academy of Sciences; University of Chinese Academy of Sciences, CAS;
   Shihezi University
RP Wang, ZH (corresponding author), Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Peoples R China.
EM wangzh@impcas.ac.cn; zhangh@impcas.ac.cn
RI Zhenhua, Wang/MTF-6201-2025; Zheng, Qiusheng/E-1643-2013; zheng,
   qiusheng/E-1643-2013
OI Zheng, Qiusheng/0000-0002-5676-1736; zheng, qiusheng/0000-0001-6413-9878
FU National Basic Research Program of China (973 Program) [2010CB834202];
   National Natural Science Foundation of China [30760058]; Shihezi
   University [RCZX200667]; Xinjiang Production and Construction Corps
   [2007JC03]; China Postdoctoral Science Foundation [200902313]
FX This study was supported by the National Basic Research Program of China
   (973 Program) (2010CB834202) to H.Z., National Natural Science
   Foundation of China (No. 30760058) to Z.W., High Level Talent Start Fund
   Project of Shihezi University (No. RCZX200667) to Z.W., Basic Research
   Project of Xinjiang Production and Construction Corps (No. 2007JC03) to
   Z.W., and Special Grade of China Postdoctoral Science Foundation (No.
   200902313) to Z.W.
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NR 66
TC 71
Z9 84
U1 0
U2 30
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD FEB 15
PY 2012
VL 19
IS 3-4
BP 355
EP 363
DI 10.1016/j.phymed.2011.09.070
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 927RS
UT WOS:000302928400025
PM 21978886
DA 2026-05-27
ER

PT J
AU Chai, YH
   Chen, F
   Li, ZJ
   Yang, PP
   Zhou, Q
   Liu, WL
   Xi, YM
AF Chai, Yihong
   Chen, Feng
   Li, Zijian
   Yang, Panpan
   Zhou, Qi
   Liu, Wenling
   Xi, Yaming
TI Mechanism of salidroside in the treatment of chronic myeloid leukemia
   based on the network pharmacology and molecular docking
SO CLINICAL & TRANSLATIONAL ONCOLOGY
LA English
DT Article
DE Salidroside; Chronic myeloid leukemia; Network pharmacology; Molecular
   docking
ID CHRONIC MYELOGENOUS LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; SIGNALING
   PATHWAYS; AKT; ANGIOGENESIS; EXPRESSION; INVASION; IMATINIB; CELLS
AB Background Salidroside is a phenolic natural product, which is a kind of Rhodiola rosea. It has been confirmed that it has inhibitory effects on chronic myeloid leukemia, but the specific performance of its molecular effects is still unclear. Objective To systematically study the pharmacological mechanism of salidroside on chronic myeloid leukemia by means of network pharmacology. Methods First, the possible target genes of salidroside were predicted through the Traditional Chinese Medicine Pharmacology Database and Analysis Platform, the target gene names were converted into standardized gene names using the Uniprot website. At the same time, the related target genes of chronic myeloid leukemia were collected from GeneCards and DisGenet; Collect summary data and screen for commonly targeted genes. Then, the above-mentioned intersected genes were imported into the String website to construct the protein-protein interaction (PPI) network, and the Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were further analyzed. To investigate the overall pharmacological effects of salidroside on chronic myeloid leukemia, we constructed a drug component-target gene-disease (CTD) network. Finally, molecular docking was performed to verify the possible binding conformation between salidroside and the candidate target. Results A total of 126 salidroside target genes were retrieved, and 106 of them had interactions with chronic myeloid leukemia. The pharmacological effects of salidroside on chronic myeloid leukemia are related to some important oncogenes and signaling pathways. Molecular docking studies confirmed that the main role of salidroside binding to the target genes is hydrogen bonding. Conclusions We revealed the potential mechanism of action of salidroside against chronic myeloid leukemia, verified by network pharmacology combined with molecular docking. However, salidroside is a promising drug for the prevention and treatment of chronic myeloid leukemia, and further research is needed to prove it.
C1 [Chai, Yihong; Chen, Feng; Li, Zijian; Yang, Panpan; Zhou, Qi; Liu, Wenling; Xi, Yaming] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China.
   [Li, Zijian; Yang, Panpan; Xi, Yaming] Lanzhou Univ, Dept Hematol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Xi, YM (corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China.; Xi, YM (corresponding author), Lanzhou Univ, Dept Hematol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
EM xiyaming02@163.com
RI Li, Zi-Jian/O-7703-2019; Yang, Panpan/GRF-1577-2022; chen,
   feng/PDX-5000-2025; Liang, Fan/CAI-0020-2022
OI Xi, Yaming/0009-0000-6868-7687; 
FU Lanzhou Science and Technology Plan Project [2020-ZD68]; Excellent
   Doctoral Research Start-up Fund of the First Hospital of Lanzhou
   University [ldyyyn2019-06]
FX Lanzhou Science and Technology Plan Project (2020-ZD68); Excellent
   Doctoral Research Start-up Fund of the First Hospital of Lanzhou
   University (ldyyyn2019-06).
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NR 47
TC 1
Z9 1
U1 0
U2 15
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1699-048X
EI 1699-3055
J9 CLIN TRANSL ONCOL
JI Clin. Transl. Oncol.
PD FEB
PY 2023
VL 25
IS 2
BP 384
EP 395
DI 10.1007/s12094-022-02990-w
EA NOV 2022
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 8J4KD
UT WOS:000881886900001
PM 36369630
DA 2026-05-27
ER

PT J
AU Chen, DJ
   Luo, C
AF Chen, Danjun
   Luo, Cong
TI Salidroside inhibits chronic myeloid leukemia cell proliferation and
   induces apoptosis by regulating the miR-140-5p/wnt5a/β-catenin axis
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE chronic myeloid leukemia; miR-140-5p; salidroside; wnt5a/beta-catenin
   pathway
ID CANCER CELLS
AB Salidroside, an active ingredient of Rhodiola rosea, exhibits antitumor effects in various types of cancer. However, the role of salidroside in chronic myeloid leukemia (CML) has not been elucidated. In the presents study, cell viability was assessed by CCK-8 assay, while apoptosis was detected by flow cytometry. Reverse transcription-quantitative PCR analysis was used to examine the expression levels of miR-140-5p in human CML cell lines. The expression levels of apoptosis and cell cycle-associated proteins and of the wnt5a/beta-catenin signaling pathway were determined by western blot analysis. Bioinformatic analysis and luciferase reporter assays were employed to investigate the association between miR-140-5p and wnt5a. The results revealed that exposure of CML cells to salidroside (80 mu M) inhibited cell proliferation and promoted apoptosis. In addition, salidroside treatment led to the upregulation of miR-140-5p expression. Furthermore, the inhibition of wnt5a/beta-catenin signaling pathway and the pro-apoptotic effects induced by salidroside were attenuated by miR-140-5p silencing. Notably, wnt5a was revealed to be a direct target of miR-140-5p. The present findings indicated that salidroside exerted anti-CML effects through regulating miR-140-5p by suppressing the wnt5a/beta-catenin signaling pathway. The present study provided evidence of the therapeutic role of salidroside in CML.
C1 [Chen, Danjun] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.
   [Luo, Cong] Univ South China, Affiliated Hosp 1, Dept Hematol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
C3 University of South China; University of South China
RP Luo, C (corresponding author), Univ South China, Affiliated Hosp 1, Dept Hematol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
EM luocong1118@126-web.net
FU 2019 Guiding project of Hengyang Science and Technology Bureau; 2019
   Hunan Provincial Natural Science Youth Fund [2019JJ50536]; 2018 National
   Natural Science Youth Fund [81803473]
FX This study was funded by a 2019 Guiding project of Hengyang Science and
   Technology Bureau (no grant number available), a 2019 Hunan Provincial
   Natural Science Youth Fund (grant no. 2019JJ50536) and a 2018 National
   Natural Science Youth Fund (grant no. 81803473).
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NR 34
TC 11
Z9 12
U1 0
U2 12
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV
PY 2021
VL 22
IS 5
AR 1249
DI 10.3892/etm.2021.10684
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA UQ2FC
UT WOS:000695884200001
PM 34539845
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Huang, ZW
   Fang, QQ
   Ma, WJ
   Zhang, QY
   Qiu, JY
   Gu, XS
   Yang, HL
   Sun, HL
AF Huang, Ziwei
   Fang, Qingqing
   Ma, Wenjing
   Zhang, Qiuyu
   Qiu, Jiaying
   Gu, Xiaosong
   Yang, Huilin
   Sun, Hualin
TI Skeletal Muscle Atrophy Was Alleviated by Salidroside Through
   Suppressing Oxidative Stress and Inflammation During Denervation
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; nerve injury; muscle atrophy; oxidative stress;
   inflammation
ID EXPRESSION; AUTOPHAGY; PATHWAY; MECHANISMS; PROTECTS; INJURY
AB Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress and inflammation are two main molecular mechanisms involved in muscle atrophy. In the current study, we want to explore whether and how salidroside, with antioxidant and anti-inflammatory properties, protects against skeletal muscle atrophy induced by denervation. First, oxidative stress and inflammatory response were examined during myotube atrophy induced by nutrition deprivation. The results demonstrated that oxidative stress and inflammatory response were induced in cultured myotubes suffered from nutrition deprivation, and salidroside not only inhibited oxidative stress and inflammatory response but also attenuated nutrition deprivation-induced myotube atrophy, as evidenced by an increased myotube diameter. The antioxidant, anti-inflammatory, and antiatrophic properties of salidroside in cultured myotubes were confirmed in denervated mouse models. The mice treated with salidroside showed less oxidative stress and less inflammatory cytokines, as well as higher skeletal muscle wet weight ratio and larger average cross sectional areas of myofibers compared with those treated with saline only during denervation-induced skeletal muscle atrophy. Moreover, salidroside treatment of denervated mice resulted in an inhibition of the activation of mitophagy in skeletal muscle. Furthermore, salidroside reduced the expression of atrophic genes, including MuRF1 and MAFbx, autophagy genes, including PINK1, BNIP3, LC3B, ATG7, and Beclin1, and transcription factor forkhead box O3 A (Foxo3A), and improved the expression of myosin heavy chain and transcriptional factor phosphorylated Foxo3A. Taken together, these results suggested that salidroside alleviated denervation-induced muscle atrophy by suppressing oxidative stress and inflammation.
C1 [Huang, Ziwei; Yang, Huilin] Soochow Univ, Affiliated Hosp 1, Inst Orthoped, Dept Orthoped, Suzhou, Peoples R China.
   [Huang, Ziwei; Fang, Qingqing; Ma, Wenjing; Zhang, Qiuyu; Qiu, Jiaying; Gu, Xiaosong; Sun, Hualin] Nantong Univ, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury R, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat,Jiangsu & Minist Educ, Nantong, Jiangsu, Peoples R China.
C3 Soochow University - China; Nantong University
RP Yang, HL (corresponding author), Soochow Univ, Affiliated Hosp 1, Inst Orthoped, Dept Orthoped, Suzhou, Peoples R China.; Sun, HL (corresponding author), Nantong Univ, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury R, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat,Jiangsu & Minist Educ, Nantong, Jiangsu, Peoples R China.
EM 546294938@qq.com; sunhl@ntu.edu.cn
RI Huang, Ziwei/IXW-8363-2023; sun, hualin/AAX-6391-2021; Qiu,
   Jiaying/PMW-6599-2026; fang, qingqing/GZK-4330-2022
FU National Key Research and Development Program of China [2017YFA0104703];
   National Natural Science Foundation of China [81871554, 81671230,
   31730031]; 973 Program [2014CB542202, 2014CB542203]; Jiangsu Provincial
   Key Medical Center; Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD)
FX This work was supported by the National Key Research and Development
   Program of China (Grant No. 2017YFA0104703), National Natural Science
   Foundation of China (Grant Nos. 81871554, 81671230, 31730031), the 973
   Program (Grant Nos. 2014CB542202 and 2014CB542203), a project funded by
   Jiangsu Provincial Key Medical Center, and the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD).
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NR 43
TC 63
Z9 71
U1 1
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD SEP 10
PY 2019
VL 10
AR 997
DI 10.3389/fphar.2019.00997
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IW7KG
UT WOS:000485167300001
PM 31616291
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lan, XZ
   Chang, K
   Zeng, LJ
   Liu, XQ
   Qiu, F
   Zheng, WL
   Quan, H
   Liao, ZH
   Chen, M
   Huang, WL
   Liu, WH
   Wang, Q
AF Lan, Xiaozhong
   Chang, Kai
   Zeng, Lingjiang
   Liu, Xiaoqiang
   Qiu, Fei
   Zheng, Weilie
   Quan, Hong
   Liao, Zhihua
   Chen, Min
   Huang, Wenlin
   Liu, Wanhong
   Wang, Qiang
TI Engineering Salidroside Biosynthetic Pathway in Hairy Root Cultures of
   Rhodiola crenulata Based on Metabolic Characterization of
   Tyrosine Decarboxylase
SO PLOS ONE
LA English
DT Article
ID ATROPA-BELLADONNA; OVEREXPRESSING PMT; GENE-EXPRESSION; PLANTS;
   ALKALOIDS; JASMONATE; ROSEA
AB Tyrosine decarboxylase initializes salidroside biosynthesis. Metabolic characterization of tyrosine decarboxylase gene from Rhodiola crenulata (RcTYDC) revealed that it played an important role in salidroside biosynthesis. Recombinant 53 kDa RcTYDC converted tyrosine into tyramine. RcTYDC gene expression was induced coordinately with the expression of RcUDPGT (the last gene involved in salidroside biosynthesis) in SA/MeJA treatment; the expression of RcTYDC and RcUDPGT was dramatically upregulated by SA, respectively 49 folds and 36 folds compared with control. MeJA also significantly increased the expression of RcTYDC and RcUDPGT in hairy root cultures. The tissue profile of RcTYDC and RcUDPGT was highly similar: highest expression levels found in stems, higher expression levels in leaves than in flowers and roots. The gene expressing levels were consistent with the salidroside accumulation levels. This strongly suggested that RcTYDC played an important role in salidroside biosynthesis in R. crenulata. Finally, RcTYDC was used to engineering salidroside biosynthetic pathway in R. crenulata hairy roots via metabolic engineering strategy of overexpression. All the transgenic lines showed much higher expression levels of RcTYDC than non-transgenic one. The transgenic lines produced tyramine, tyrosol and salidroside at higher levels, which were respectively 3.21-6.84, 1.50-2.19 and 1.27-3.47 folds compared with the corresponding compound in non-transgenic lines. In conclusion, RcTYDC overexpression promoted tyramine biosynthesis that facilitated more metabolic flux flowing toward the downstream pathway and as a result, the intermediate tyrosol was accumulated more that led to the increased production of the end-product salidroside.
C1 [Lan, Xiaozhong; Zheng, Weilie; Quan, Hong] Tibet Univ, Agr & Anim Husb Coll, Nyingchi Of Tibet, Peoples R China.
   [Lan, Xiaozhong; Chang, Kai; Zeng, Lingjiang; Liu, Xiaoqiang; Qiu, Fei; Liao, Zhihua; Huang, Wenlin] Southwest Univ, Chongqing Engn & Technol Res Ctr Sweetpotato, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Minist Educ,Sch Life Sci, Chongqing, Peoples R China.
   [Chen, Min] Southwest Univ, Sch Pharmaceut Sci, Chongqing, Peoples R China.
   [Liu, Wanhong] Chongqing Univ Sci & Technol, Sch Chem & Chem Engn, Chongqing, Peoples R China.
   [Wang, Qiang] Minist Sci & Technol, China Rural Technol Dev Ctr, Beijing, Peoples R China.
C3 Xizang Agricultural & Animal Husbandry University; Xizang University;
   Southwest University - China; Southwest University - China; Chongqing
   University of Science & Technology
RP Liao, ZH (corresponding author), Southwest Univ, Chongqing Engn & Technol Res Ctr Sweetpotato, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Minist Educ,Sch Life Sci, Chongqing, Peoples R China.
EM zhliao@swu.edu.cn; mminchen@163.com
RI huang, wenlin/H-7572-2016
OI Chang, Kai/0000-0001-6013-9256
FU Natural Science Foundation Project of Chongqing [2010BB5296]; NSFC
   Project [31070266]; National Science & Technology Pillar Program
   [2011BAI13B06]; Tibet Medicinal Resources Investigation Project (State
   Administration of Chinese Traditional Medicine) [20120716-540000]; Tibet
   Science and Technology Funding
FX The research was financially supported by the Natural Science Foundation
   Project of Chongqing (2010BB5296), the NSFC Project (31070266), the
   National Science & Technology Pillar Program (2011BAI13B06), Tibet
   Medicinal Resources Investigation Project (State Administration of
   Chinese Traditional Medicine 20120716-540000) and Tibet Science and
   Technology Funding. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 28
TC 55
Z9 68
U1 4
U2 80
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 4
PY 2013
VL 8
IS 10
AR e75459
DI 10.1371/journal.pone.0075459
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 232JF
UT WOS:000325489100049
PM 24124492
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yuan, XY
   Pang, XW
   Zhang, GQ
   Guo, JY
AF Yuan, Xiao-Ying
   Pang, Xiao-Wen
   Zhang, Guo-Qiang
   Guo, Jian-You
TI Salidroside's Protection Against UVB-Mediated Oxidative Damage and
   Apoptosis Is Associated with the Upregulation of Nrf2 Expression
SO PHOTOMEDICINE AND LASER SURGERY
LA English
DT Article
DE photobiology; photomedicine; skin
ID ULTRAVIOLET-RADIATION; SIGNALING PATHWAY; RHODIOLA-ROSEA; SKIN; CELLS;
   STRESS; SULFORAPHANE; RESPONSES; GENES; PHOTOCARCINOGENESIS
AB Background: Salidroside is the major active component of Rhodiola rosea, a traditional Chinese herbal medicine used for protection against ultraviolet (UV) radiation. Objectives: This study investigated whether salidroside can protect skin from ultraviolet B (UVB)-induced oxidative damage in human immortalized HaCaT keratinocytes and the skin of guinea pigs. Methods: Using HaCaT cell models, the effects of salidroside on oxidative damage and possible regulatory factors [including NF-E2-related factor 2 (Nrf2), NAD(P) H-quinone oxidoreductase (NQO1), and heme oxygenase 1 (HO-1)] were examined. In addition, the regulatory effects of salidroside on apoptotic sunburn cells (SBCs) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)-positive epidermal cells on UVB-exposed guinea pig skin were also investigated. Results: We found that salidroside pretreatment upregulated Nrf2 translocation to the nucleus and transcription activity in HaCaT cells, as reflected by the increased nuclear accumulation of Nrf2 as well as the gene and protein expression of downstream Nrf2 antioxidants, including NQO1 and HO-1. In addition, we also found that pretreatment with salidroside reactive oxygen species (ROS) in irradiated HaCaT cells. The oral administration of salidroside (0.1% w/w) to guinea pigs inhibited the UVB-mediated formation of apoptotic SBCs and 8-OHdG-positive epidermal cells in the skin of guinea pigs. Conclusions: Our results show that UVB-induced oxidative damage can be prevented by salidroside with upregulation of nuclear Nrf2 expression.
C1 [Yuan, Xiao-Ying; Pang, Xiao-Wen] Air Force Gen Hosp, Dept Dermatol, Beijing, Peoples R China.
   [Zhang, Guo-Qiang] Hebei Med Univ, Dept Dermatol, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China.
   [Guo, Jian-You] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
C3 Air Force General Hospital PLA; Hebei Medical University; Chinese
   Academy of Sciences; Institute of Psychology, CAS
RP Zhang, GQ (corresponding author), Hebei Med Univ, Dept Dermatol, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China.; Guo, JY (corresponding author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
EM zgq810328@sina.com; guojy@psych.ac.cn
RI Pang, Xiaowen/NFT-0905-2025; Guo, Jian-You/AEW-6817-2022; Zhang,
   Guoqiang/GXH-3540-2022; Yuan, Xiao-Ying/ABG-8705-2022
OI Zhang, Guoqiang/0000-0002-4132-1690; Yuan, Xiao-Ying/0000-0002-0378-2859
FU National Natural Science Foundation of China [81000706]; Key Laboratory
   of Mental Health, Institute of Psychology, Chinese Academy of Sciences
FX This work was supported by a grant from the National Natural Science
   Foundation of China (81000706), a project from the Key Laboratory of
   Mental Health, Institute of Psychology, Chinese Academy of Sciences. We
   thank Prof. G.J.Y. for the critical review of the article.
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Z9 26
U1 2
U2 49
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-5418
EI 1557-8550
J9 PHOTOMED LASER SURG
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PD JAN
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VL 35
IS 1
BP 49
EP 56
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PG 8
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EH5ZR
UT WOS:000391852400008
PM 27627465
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zhang, XX
   Zhang, HT
   Liu, ZX
   Huang, TK
   Yi, R
   Ma, ZC
   Gao, Y
AF Zhang, Xianxie
   Zhang, Huiting
   Liu, Zuoxu
   Huang, Tianke
   Yi, Ru
   Ma, Zengchun
   Gao, Yue
TI Salidroside improves blood-brain barrier integrity and cognitive
   function in hypobaric hypoxia mice by inhibiting microglia activation
   through GSK3β
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE blood-brain barrier; GSK3 beta; hypobaric hypoxia brain injury;
   microglia; Salidroside
ID PERMEABILITY; CELL
AB Salidroside, an active component found in Rhodiola rosea L., has emerged as a potential therapeutic agent for the prevention and treatment of hypoxic brain injury, while the precise target and mechanism of salidroside were remain unclear. The study utilized techniques such as network pharmacology, transcriptome sequencing to investigate the mechanism and target of salidroside in regulating blood-brain barrier (BBB) function to protect hypoxic brain injury in vivo. Utilized macromolecular docking and molecular biology techniques to explore the molecular mechanism of salidroside in alleviating brain injury induced by hypoxia in BV2 cell model. The results show that salidroside alleviated the learning and memory dysfunction and pathological injury in mice exposed to hypobaric hypoxia, reduced brain water content and attenuate the inflammatory response and oxidative stress, effectively reversed S100 beta in serum and promoted the repair of BBB. GSK3 beta is an important therapeutic target of salidroside in the treatment of hypoxic cognitive impairment, and salidroside can specifically bind GSK3 beta in the ATP binding pocket, inducing the phosphorylation of GSK3 beta, targeting downstream Nrf-2 to regulate microglia activity, promoting the accumulation of beta-catenin, thereby inhibiting microglial activation, improving the BBB integrity injury and achieving a neuroprotective effect. This study demonstrates that salidroside can inhibit the activation of microglia by inducing GSK3 beta phosphorylation, achieve neuroprotective effects and alleviate learning and memory dysfunction in hypobaric hypoxia mice. This study provides a theoretical basis for the development of salidroside and the clinical application of Rhodiola rosea L.
C1 [Zhang, Xianxie; Zhang, Huiting; Liu, Zuoxu; Huang, Tianke; Yi, Ru; Ma, Zengchun; Gao, Yue] Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China.
   [Zhang, Huiting; Liu, Zuoxu; Huang, Tianke; Ma, Zengchun] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Peoples R China.
C3 Academy of Military Medical Sciences - China; Guangdong Pharmaceutical
   University
RP Ma, ZC; Gao, Y (corresponding author), Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China.; Ma, ZC (corresponding author), Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Peoples R China.
EM mazchun@139.com; gaoyue@bmi.ac.cn
RI Zhang, Huiting/IQW-3491-2023
OI zhang, xianxie/0000-0003-3166-3694
FU Innovation Team and Talents Cultivation Program of National
   Administration of Traditional Chinese Medicine
FX We thank all the participants. We gratefully acknowledge the
   participation of Beijing Digitf Biotechnology Co., Ltd. (Beijing) for
   the support of data analysis.
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NR 37
TC 11
Z9 13
U1 3
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2025
VL 39
IS 4
SI SI
BP 1808
EP 1825
DI 10.1002/ptr.8264
EA OCT 2024
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1SE2X
UT WOS:001328577200001
PM 39364585
OA Bronze
DA 2026-05-27
ER

PT J
AU Zhao, G
   Shi, AP
   Fan, ZM
   Du, Y
AF Zhao, Gang
   Shi, Aiping
   Fan, Zhimin
   Du, Ye
TI Salidroside inhibits the growth of human breast cancer in vitro
   and in vivo
SO ONCOLOGY REPORTS
LA English
DT Article
DE breast cancer; salidroside; tumor growth
ID PEROXIDE-INDUCED INJURY; SIGNALING PATHWAYS; NATURAL-PRODUCTS;
   CELL-DEATH; APOPTOSIS; INVASION; RENAISSANCE; STATISTICS; EXPRESSION;
   INDUCTION
AB Salidroside has been identified as one of the most potent compounds isolated from the plant Rhodiola rosea, and was found to have several important biological properties, including antioxidant and anti-inflammatory activity; however, its anticancer effects are poorly understood. Thus, the present study focused on evaluating the effects of purified salidroside on the growth of human breast cancer in vitro and in vivo, and on further investigating its possible molecular mechanisms. The human breast cancer cell line, MCF-7, was incubated with various concentrations of salidroside, and cell proliferation, colony formation, cell cycle distribution, apoptosis, migration and invasion were assayed by several in vitro approaches. As a result, it was found that salidroside treatment significantly inhibited cell proliferation, colony formation, migration and invasion, as well as induced cell apoptosis and cell cycle arrest at the G0/G1 phase in vitro. In addition, we also evaluated the effect of salidroside on tumor growth in a nude mouse model, and found that salidroside treatment significantly suppressed tumor growth in vivo. We also further disclosed that salidroside treatment significantly inhibited the intracellular reactive oxygen species (ROS) formation and MAPK pathway activation, which may contribute to the inhibition of tumor growth of breast cancer and reduction of oxidative stress. In conclusion, these findings suggest that salidroside may be a promising candidate target for the prevention and treatment of human breast cancer.
C1 [Zhao, Gang; Shi, Aiping; Fan, Zhimin; Du, Ye] Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University
RP Du, Y (corresponding author), Jilin Univ, Hosp 1, Dept Breast Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM duye2134@l26.com
OI shi, aiping/0000-0002-7272-453X
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NR 39
TC 75
Z9 88
U1 1
U2 41
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1021-335X
EI 1791-2431
J9 ONCOL REP
JI Oncol. Rep.
PD MAY
PY 2015
VL 33
IS 5
BP 2553
EP 2560
DI 10.3892/or.2015.3857
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CG3LE
UT WOS:000353180900056
PM 25814002
OA Bronze
DA 2026-05-27
ER

PT J
AU Zhang, L
   Liu, YW
   Hua, ZJ
   Qin, Y
   Wang, T
   Li, N
   Song, L
AF Zhang, Lan
   Liu, Yawei
   Hua, Zhijuan
   Qin, Yan
   Wang, Tao
   Li, Na
   Song, Lei
TI Salidroside alleviates cardiomyocyte senescence by activating the
   AMPK-mediated signaling pathway
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE Salidroside; Cardiomyocytes; Senescence; AMPK; cGAS-STING
AB Cardiovascular aging is a key contributor to cardiovascular diseases (CVDs). As individuals age, the frequency and severity of cardiovascular events rise, establishing CVDs as a primary cause of death in older adults. Therefore, the development and exploration of drugs or bioactive molecules that can effectively prevent cardiovascular aging and related diseases are urgently needed. This study evaluated the effects of salidroside, a key component of Rhodiolarosea extract, on cardiomyocyte senescence. We established an in vitro cardiomyocyte senescence model using D-gal/H2O2 induction. A series of experimental techniques, including Western blot, indirect immunofluorescence, ELISA, and flow cytometry, were employed. The findings indicated that salidroside markedly reduced cardiomyocyte senescence in this model, as shown by Sa-beta-gal staining and the evaluation of senescence-associated markers such as p16, p21, and p53. Additionally, salidroside reduced senescence-associated inflammation and oxidative stress levels. Additional mechanistic research demonstrated that salidroside promotes anti-aging by repairing DNA damage. In summary, this study systematically evaluated the potential biological activity of salidroside in combating cardiomyocyte aging and demonstrated its promising anti-aging effects. These findings suggest that salidroside could serve as a functional food ingredient with anti-aging properties, offering new strategies for preventing cardiovascular aging and related diseases.
C1 [Zhang, Lan; Liu, Yawei; Song, Lei] Hebei Univ, Dept Integrated Tradit Chinese & Western Med, Affiliated Hosp, Baoding, Peoples R China.
   [Hua, Zhijuan; Wang, Tao] Hebei Univ, Affiliated Hosp, Baoding, Peoples R China.
   [Qin, Yan] Hebei Univ, Affiliated Hosp, Expt Ctr, Baoding, Peoples R China.
   [Li, Na] Hebei Univ, Affiliated Hosp, Dept Intervent Vasc Dis, Baoding, Peoples R China.
C3 Hebei University; Hebei University; Hebei University; Hebei University
RP Song, L (corresponding author), Hebei Univ, Dept Integrated Tradit Chinese & Western Med, Affiliated Hosp, Baoding, Peoples R China.; Li, N (corresponding author), Hebei Univ, Affiliated Hosp, Dept Intervent Vasc Dis, Baoding, Peoples R China.
EM zhanglan.syy@163.com; songlei78630819@163.com
FU Cultivation Project of the Joint Fund for Traditional Chinese Medicine
   of the Natural Science Foundation of Hebei Province [H2023201018];
   Scientific Research Plan Project of the Traditional Chinese Medicine
   Administration of Hebei Province [2022417, 2023330, 2024071, 2025060];
   National Health and Medical Research Council (NHMRC) [2022417] Funding
   Source: National Health and Medical Research Council (NHMRC)
FX This work was supported by the Cultivation Project of the Joint Fund for
   Traditional Chinese Medicine of the Natural Science Foundation of Hebei
   Province, No. H2023201018; Scientific Research Plan Project of the
   Traditional Chinese Medicine Administration of Hebei Province, No.
   2022417; Scientific Research Plan Project of the Traditional Chinese
   Medicine Administration of Hebei Province, No. 2023330; Scientific
   Research Plan Project of the Traditional Chinese Medicine Administration
   of Hebei Province, No. 2024071; Scientific Research Plan Project of the
   Traditional Chinese Medicine Adminis-tration of Hebei Province, No.
   2025060
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NR 26
TC 0
Z9 0
U1 8
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD AUG 6
PY 2025
VL 56
IS 4
AR 252
DI 10.1007/s10735-025-10546-9
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 5VG8W
UT WOS:001545166500002
PM 40767997
DA 2026-05-27
ER

PT J
AU Sun, XC
   Liu, X
   Zhao, GR
AF Sun, Xiaocui
   Liu, Xue
   Zhao, Guang-Rong
TI Separation of salidroside from the fermentation broth of engineered
   Escherichia coli using macroporous adsorbent resins
SO CHINESE JOURNAL OF CHEMICAL ENGINEERING
LA English
DT Article
DE Adsorption; Desorption; Fermentation; Macroporous resin; Salidroside
ID RHODIOLA-SACHALINENSIS; TYROSOL; PURIFICATION; EXTRACTION;
   CHROMATOGRAPHY; ADSORPTION; CRENULATA; L.
AB Salidroside (8-O-b-D-glucoside of tyrosol), a plant-derived natural product, is used for treatment of hypoxia, fatigue and aging diseases. The availability of salidroside is restricted since it is extracted from 3-5 years old Rhodiola roots, which grow very slowly in the cold region of northern hemisphere of Earth. Our laboratory has constructed an engineered Escherichia coli and established a fermentation process to produce salidroside from glucose. In this article, nine macroporous resins from polarity to non-polarity, including NKA-9, S-8, AB-8, SP825, D101, LSA-8, LX-12, LX-18 and LX-68 resins, were tested to separate salidroside from fermentation broth. After static and dynamic experiments, the weakly polar SP825 resin had a better separation efficiency among nine resins. The adsorption kinetic and isotherm of salidroside on the SP825 resin were determined, and the pseudo-second-order kinetic model and Langmuir model could be fitted well. The effects of the pH on adsorption and ethanol concentration on desorption were investigated, and an optimal separation process was established. The adsorption for salidroside in the SP825 resin column was conducted with loading 150 ml at pH 7, and desorpted by washing 50 ml of 80% ethanol solution. Under the best process conditions, the purity and yield of salidroside in the final product were 91.6% and 74.0%, respectively. The results showed that the macroporous SP825 resin would be feasible and effective to prepare salidroside and has promising application in the downstream process of microbial fermentation. (c) 2021 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd.
C1 [Sun, Xiaocui; Liu, Xue; Zhao, Guang-Rong] Tianjin Univ, Frontier Sci Ctr Synthet Biol, Yaguan Rd 135, Tianjin 300350, Peoples R China.
   [Sun, Xiaocui; Liu, Xue; Zhao, Guang-Rong] Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Syst Bioengn, Yaguan Rd 135, Tianjin 300350, Peoples R China.
   [Zhao, Guang-Rong] Tianjin Univ, Georgia Tech Shenzhen Inst, Shenzhen 518071, Peoples R China.
C3 Tianjin University; Tianjin University; Tianjin University
RP Zhao, GR (corresponding author), Tianjin Univ, Frontier Sci Ctr Synthet Biol, Yaguan Rd 135, Tianjin 300350, Peoples R China.; Zhao, GR (corresponding author), Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Syst Bioengn, Yaguan Rd 135, Tianjin 300350, Peoples R China.
EM grzhao@tju.edu.cn
FU Key-Area Research and Development Program of Guangdong Province
   [2020B0303070002]
FX This work was supported by The Key-Area Research and Development Program
   of Guangdong Province (2020B0303070002), China.
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NR 40
TC 4
Z9 4
U1 4
U2 56
PU CHEMICAL INDUSTRY PRESS CO LTD
PI BEIJING
PA NO 13, QINGNIANHU SOUTH ST, DONGCHENG DIST, BEIJING 100011, PEOPLES R
   CHINA
SN 1004-9541
EI 2210-321X
J9 CHINESE J CHEM ENG
JI Chin. J. Chem. Eng.
PD APR
PY 2022
VL 44
BP 260
EP 267
DI 10.1016/j.cjche.2021.02.019
EA APR 2022
PG 8
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA 1F0IJ
UT WOS:000794860600003
DA 2026-05-27
ER

PT J
AU Yan, R
   Xu, H
   Fu, XX
AF Yan, Rui
   Xu, Hua
   Fu, Xiaoxiang
TI Salidroside protects hypoxia-induced injury by up-regulation of miR-210
   in rat neural stem cells
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Hypoxia; Neural stem cells; miR-210; BTG3
ID ROSEA L. EXTRACT; BRAIN-INJURY; INDUCIBLE FACTOR-1-ALPHA; CANCER;
   EXPRESSION; PROLIFERATION; ISCHEMIA; GROWTH; BTG3; APOPTOSIS
AB Neonatal brain hypoxia is a disease that affects the nervous system in children. Salidroside is a compound that has an anti-hypoxic effect, but the mechanism of salidroside in neonatal cerebral hypoxia is unclear. Hence, we investigated the regulatory effect and mechanism of salidroside on hypoxic-induced injury of neural stem cells (NSCs). NSCs derived from embryo 14 Sprague-Dawley rats were treated by hypoxia, followed by the treatment of 0.8 mM salidroside. The expression levels of miR-210 and BTG3 in NSCs were altered by transfection. Cell viability and apoptosis were examined by CCK-8 and flow cytometry analysis. qRT-PCR and Western blot were performed to assess the expression changes of miR-210, BTG3, apoptosis-related factors and core factors in PI3K/AKT/mTOR pathway. We found that hypoxia induced an apoptosis-dependent death in NSCs. Salidroside exerted bFGF-like effect, as it alleviated hypoxia-induced viability impairment and apoptosis in NSCs. Further studies showed that hypoxia plus salidroside elevated miR-210 expression, and the protective actions of salidroside on hypoxia-modulated death in NSCs were attenuated by miR-210 suppression, while were enhanced by miR-210 overexpression. Besides, BTG3 was negatively regulated by miR-210. Overexpression of BTG3 inhibited the activation of PI3K/AKT/mTOR signaling pathway; of contrast, suppression of BTG3 promoted it. To conclude, this study provide in vitro evidence that salidroside protected NSCs against hypoxia-induced injury by up-regulation of miR-210, which in turn inhibited the expression of BTG3 and activated PI3K/AKT/mTOR signaling pathway.
C1 [Yan, Rui] Women & Childrens Hlth Care Hosp Linyi, Dept Children Rehabil, Linyi 276016, Shandong, Peoples R China.
   [Xu, Hua] Childrens Hosp Kaifeng City, Kaifeng 475000, Henan, Peoples R China.
   [Fu, Xiaoxiang] Women & Childrens Hlth Care Hosp Linyi, Dept Child Hlth Care, 1 Qinghe South Rd, Linyi 276016, Shandong, Peoples R China.
RP Fu, XX (corresponding author), Women & Childrens Hlth Care Hosp Linyi, Dept Child Hlth Care, 1 Qinghe South Rd, Linyi 276016, Shandong, Peoples R China.
EM fuxiaoxiang0029@sina.com
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NR 43
TC 35
Z9 38
U1 0
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2018
VL 103
BP 1490
EP 1497
DI 10.1016/j.biopha.2018.04.184
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GH3UW
UT WOS:000433328800175
PM 29864934
DA 2026-05-27
ER

PT J
AU Calabrese, EJ
   Dhawan, G
   Kapoor, R
   Agathokleous, E
   Calabrese, V
AF Calabrese, Edward J.
   Dhawan, Gaurav
   Kapoor, Rachna
   Agathokleous, Evgenios
   Calabrese, Vittorio
TI Rhodiola rosea and salidroside commonly induce hormesis,
   with particular focus on longevity and neuroprotection
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Review
DE Rhodiola rosea; Salidroside; Hormesis; Dose response; Biphasic dose
   response; Phytomedicine
ID STIMULATES OSTEOBLAST DIFFERENTIATION; HORMETIC DOSE RESPONSES;
   HISTORICAL FOUNDATIONS; RADIATION HORMESIS; STRESS RESISTANCE; INDUCED
   APOPTOSIS; OXIDATIVE STRESS; SCIATIC-NERVE; DNA-DAMAGE; CELLS
AB The biological effects of Rhodiola rosea extracts and one of its major constituents, salidroside, were evaluated for their capacity to induce hormesis/hormetic effects. The findings indicate that the Rhodiola rosea extracts and salidroside commonly induce hormetic dose responses within a broad range of biological models, cell types and across a broad range of endpoints, with particular emphasis on longevity and neuroprotective endpoints. This paper represents the first integrative documentation and assessment of Rhodiola rosea extracts and salidroside induction of hormetic effects. These findings have important biomedical applications and should have an important impact with respect to critical study design, dose selection and other experimental features.
C1 [Calabrese, Edward J.] Univ Massachusetts, Dept Environm Hlth Sci, Morrill 1,N344, Amherst, MA 01003 USA.
   [Dhawan, Gaurav] Stantec ChemRisk, Boston, MA USA.
   [Kapoor, Rachna] St Francis Hosp & Med Ctr, Hartford, CT USA.
   [Agathokleous, Evgenios] Nanjing Univ Informat Sci & Technol, Sch Appl Meteorol, Dept Ecol, Nanjing 210044, Peoples R China.
   [Calabrese, Vittorio] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Via Santa Sofia 97, I-95123 Catania, Italy.
C3 University of Massachusetts System; University of Massachusetts Amherst;
   Saint Francis Hospital & Medical Center; Nanjing University of
   Information Science & Technology; University of Catania
RP Calabrese, EJ (corresponding author), Univ Massachusetts, Dept Environm Hlth Sci, Morrill 1,N344, Amherst, MA 01003 USA.
EM edwardc@umass.edu; gaurav.dhawan@stantec.com;
   dr.rachnakapoor23@gmail.com; evgenios@nuist.edu.cn; calabres@unict.it
RI Dhawan, Gaurav/I-7098-2019; Calabrese, Vittorio/AAC-8157-2021;
   Agathokleous, Evgenios/D-2838-2016; /AAP-1186-2020
OI Dhawan, Gaurav/0000-0003-0511-7323; Agathokleous,
   Evgenios/0000-0002-0058-4857; 
FU US Air Force [AFOSR FA9550-19-1-0413]; ExxonMobil Foundation
   [S18200000000256]
FX Funding EJC acknowledges longtime support from the US Air Force (AFOSR
   FA9550-19-1-0413) and ExxonMobil Foundation (S18200000000256) . The U.S.
   Government is authorized to reproduce and distribute for governmental
   purposes notwithstanding any copyright notation thereon. The views and
   conclusions contained herein are those of theauthor and should not be
   interpreted as necessarily representing policies or endorsement, either
   expressed or implied. Sponsors had no involve-ment in study design,
   collection, analysis, interpretation, writing and decision to and where
   to submit for publication consideration.
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NR 85
TC 18
Z9 26
U1 6
U2 41
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD AUG 1
PY 2023
VL 380
AR 110540
DI 10.1016/j.cbi.2023.110540
EA MAY 2023
PG 11
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA J0LV2
UT WOS:001006616100001
PM 37169278
DA 2026-05-27
ER

PT J
AU Sun, MY
   Ma, DS
   Zhao, S
   Wang, L
   Ma, CY
   Bai, Y
AF Sun, Meng-Yao
   Ma, Da-Shi
   Zhao, Song
   Wang, Lei
   Ma, Chun-Ye
   Bai, Yang
TI RETRACTED: Salidroside mitigates hypoxia/reoxygenation injury by
   alleviating endoplasmic reticulum stress-induced apoptosis in H9c2
   cardiomyocytes (Retracted Article)
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article; Retracted Publication
DE salidroside; myocardial ischemia; reperfusion injury; endoplasmic
   reticulum stress; apoptosis; cardioprotection
ID ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL-ISCHEMIA; THERAPEUTIC TARGET;
   ISCHEMIA/REPERFUSION INJURY; SIGNALING PATHWAY; OXIDATIVE STRESS; CELL;
   PROTECTS; ER; PERK
AB Endoplasmic reticulum (ER) stress-induced apoptosis serves a crucial role in the development of myocardial ischemia/reperfusion (I/R) injury. Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., which is a plant often used in traditional Chinese medicine. It possesses multiple pharmacological actions and protects against myocardial I/R injury in vitro and in vivo. However, it is not yet clear whether ER stress or ER stress-induced apoptosis contributes to the cardioprotective effects of salidroside against myocardial I/R injury. Hence, hypoxia/reoxygenation (H/R)-treated H9c2 cardiomyocytes were used in the current study to mimic myocardium I/R injury in vivo. It was hypothesized that salidroside alleviates ER stress and ER stress-induced apoptosis, thereby reducing H/R injury in H9c2 cells. The results demonstrated that salidroside attenuated H/R-induced H9c2 cardiomyocyte injury, as cell viability was increased, lactate dehydrogenase release was decreased, morphological changes in apoptotic cells were ameliorated and the apoptosis ratio was reduced compared with the H/R group. ER stress was reversed, indicated by the downregulation of glucose regulated protein 78 and C/EBP homologous protein following pretreatment with salidroside. In addition, salidroside attenuated ER stress-induced apoptosis, as the expression of cleaved caspase-12 and pro-apoptotic protein Bcl-2 associated X protein and activity of caspase-3 was decreased, while the expression of anti-apoptotic protein Bcl-2 was increased following pretreatment with salidroside. Furthermore, the results indicated that salidroside decreases the activation of the ER stress-associated signaling pathway, as the expression of phosphorylated protein kinase RNA (PKR)-like ER kinase (p-PERK) and phosphorylated inositol-requiring enzyme-1 (p-IRE1) proteins were decreased following pretreatment with salidroside. These results demonstrate that salidroside protects against H/R injury via regulation of the PERK and IRE1 pathways, resulting in alleviation of ER stress or ER stress-induced apoptosis in H9c2 cardiomyocytes.
C1 [Sun, Meng-Yao; Ma, Da-Shi; Wang, Lei; Ma, Chun-Ye; Bai, Yang] Jilin Univ, Hosp 1, Dept Cardiac Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
   [Zhao, Song] Jilin Univ, Hosp 1, Dept Spine Surg, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Bai, Y (corresponding author), Jilin Univ, Hosp 1, Dept Cardiac Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM baiyang010301@foxmail.com
FU National Science Foundation of China [81300186, 81301035]
FX The present study was supported by the National Science Foundation of
   China (grant nos. 81300186 and 81301035).
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NR 49
TC 33
Z9 40
U1 0
U2 27
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD OCT
PY 2018
VL 18
IS 4
BP 3760
EP 3768
DI 10.3892/mmr.2018.9403
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GT1RQ
UT WOS:000444252200026
PM 30132527
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Yang, HT
   Yang, QW
   Zheng, LF
AF Yang, Haitao
   Yang, Qingwu
   Zheng, Linfei
TI Inhibition of hypoxia-inducible factor-1 by salidroside in an in
   vitro model of choroidal neovascularization
SO CUTANEOUS AND OCULAR TOXICOLOGY
LA English
DT Article
DE Salidroside; choroidal neovascularization; RF; 6A cells; tube formation;
   hypoxia-inducible factor-1
ID ENDOTHELIAL GROWTH-FACTOR; MACULAR DEGENERATION; FACTOR EXPRESSION;
   ANGIOGENESIS; RANIBIZUMAB; INJURY; CELLS
AB Purpose As a characteristic of age-related macular degeneration (AMD), choroidal neovascularization (CNV) causes severe vision loss. The current treatment has limited efficacy. This study was to investigate effects of Salidroside against CNV and explore its underlying mechanisms. Methods RF/6A cells were treated with 200 mM cobalt chloride (CoCl2) for 6 hr to mimic hypoxic condition. Cells were then treated with Salidroside at 10, 30, and 100 mu M for 24 hr. Cells treated with DMSO were used as negative control. The cell proliferation was assessed using 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium-bromid assay. The tube formation was investigated on Matrigel. The cell migration was measured by a Transwell assay. RT-qPCR was used to detect the gene expression. Immuohistochemistry and western blot were used to detect the expression of proteins. Results Salidroside significantly inhibited the cell migration and tube formation activity of RF/6A cells under hypoxia. Moreover, Salidroside reduced the expression levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1) in RF/6A cells. Conclusions Our data suggested that Salidroside could be a potential novel therapeutic agent against CNV.
C1 [Yang, Haitao; Yang, Qingwu; Zheng, Linfei] Xiamen Univ, Dept Neurosurg, Fuzhou Hosp 2, Fuzhou, Peoples R China.
C3 Xiamen University
RP Zheng, LF (corresponding author), Xiamen Univ, Dept Neurosurg, Fuzhou Hosp 2, Fuzhou, Peoples R China.
EM zhenglinfei11@yeah.net
RI Yang, Qingwu/LWJ-1651-2024
OI Yang, Qingwu/0000-0002-2596-2631
FU Key Clinical Specialty Discipline Construction Program of Fuzhou
   [201912006]
FX This research was supported by Key Clinical Specialty Discipline
   Construction Program of Fuzhou [No. 201912006].
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NR 35
TC 5
Z9 6
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1556-9527
EI 1556-9535
J9 CUTAN OCUL TOXICOL
JI Cutan. Ocul. Toxicol.
PD JUL 3
PY 2022
VL 41
IS 3
BP 203
EP 209
DI 10.1080/15569527.2021.1973023
EA JUL 2022
PG 7
WC Ophthalmology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology; Toxicology
GA 4L5MR
UT WOS:000826029800001
PM 34428999
DA 2026-05-27
ER

PT J
AU Yang, PP
   Chai, YH
   Wei, M
   Ge, Y
   Xu, FX
AF Yang, Panpan
   Chai, Yihong
   Wei, Min
   Ge, Yan
   Xu, Feixue
TI Mechanism of salidroside in the treatment of endometrial cancer based on
   network pharmacology and molecular docking
SO SCIENTIFIC REPORTS
LA English
DT Article
ID EXPRESSION; INHIBITION; CARCINOMA; APOPTOSIS; CELLS; GENE; EGFR;
   PROLIFERATION; MIGRATION; PATHWAYS
AB Salidroside is a natural product of phenols, which has a wide scape of pharmacological effects, but its pharmacological effects and molecular mechanism on endometrial cancer are not clear. To systematically explore the pharmacological effects and molecular mechanisms of salidroside on endometrial cancer through the method of network pharmacology. The possible target genes of salidroside were obtained through different pharmacological databases and analysis platforms, and then the relevant target genes of endometrial cancer were obtained through the GeneCards website, and the target genes were uniformly converted into standardized gene names with Uniprot. The collected data were then processed to obtain common target genes and further analyzed through the String website to construct a protein-protein interaction (PPI) network, followed by gene ontology (GO) functional annotation and Kyoto Gene and Genome Encyclopedia (KEGG) pathway analysis. We further interpreted the molecular mechanism of salidroside for the treatment of endometrial cancer by constructing a "drug component-target gene-disease" network. Finally, we performed molecular docking to validate the binding conformation between salidroside and the candidate target genes. There were 175 target genes of salidroside after normalization, among which 113 target genes interacted with endometrial cancer. GO analysis indicated that the anti-endometrial cancer effect of salidroside may be strongly related to biological processes such as apoptosis and response to drug. KEGG analysis indicated that its mechanism may be related to pathway in cancer and PI3K-AKT signaling pathway. Molecular docking showed that salidroside had high affinity with five key genes. Based on the novel network pharmacology and molecular docking validation research methods, we have revealed for the first time the potential mechanism of salidroside in the therapy of endometrial cancer.
C1 [Yang, Panpan; Wei, Min; Ge, Yan; Xu, Feixue] Lanzhou Univ, Dept Obstet & Gynecol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
   [Yang, Panpan; Chai, Yihong; Wei, Min; Xu, Feixue] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Xu, FX (corresponding author), Lanzhou Univ, Dept Obstet & Gynecol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China.; Xu, FX (corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China.
EM xfx.sxq@163.com
RI pan, yang/JSL-1184-2023
FU The authors would like to thank the participating centers and members.
FX The authors would like to thank the participating centers and members.
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U1 3
U2 16
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 29
PY 2023
VL 13
IS 1
AR 14114
DI 10.1038/s41598-023-41157-7
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q5PG6
UT WOS:001058035700058
PM 37644107
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Song, D
   Zhao, M
   Feng, LX
   Wang, PY
   Li, YM
   Li, WH
AF Song, Dan
   Zhao, Min
   Feng, Liuxiang
   Wang, Pingyi
   Li, Yimei
   Li, Wenhua
TI Salidroside attenuates acute lung injury via inhibition of inflammatory
   cytokine production
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Acute lung injury; LPS; TNF alpha; IL-6
ID MODELS
AB Acute lung injury is a fatal condition characterized by excessive inflammation responses. Salidroside, the active constituent of Rhodiola rosea, possesses properties including anti-oxidation, anti-aging, anti-inflammatory, anti-hypoxia, and anti-cancer activities. In the present study, Salidmside attenuated acute lung injury via inhibition of inflammatory cytokine production. Rats pre-treated with Salidroside showed attenuated lipopolysaccharide (LPS)-induced pathological damage and suppressed tumor necrosis factor-alpha (TNF alpha) and interleukin 6 (IL-6) secretion in the lung. Furthermore, flow cytometry showed that Salidroside reduced the production of TNF alpha and IL-6 in NR8383 alveolar macrophages. These findings suggest that Salidroside may attenuate LPS-induced acute lung injury.
C1 [Song, Dan; Zhao, Min; Li, Wenhua] Xizang Minzu Univ, Sch Med, Engn Res Ctr Tibetan Med Detect Technol, Minist Educ, Xianyang 712082, Shaanxi, Peoples R China.
   [Song, Dan; Zhao, Min; Wang, Pingyi; Li, Yimei; Li, Wenhua] Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China.
   [Feng, Liuxiang] Peoples Hosp Yulong Naxi Autonomous Cty Lijiang C, Yulong Naxi Autonomous C 674100, Yunnan, Peoples R China.
C3 Xizang Minzu University; Xizang Minzu University
RP Li, WH (corresponding author), Xizang Minzu Univ, Sch Med, Xianyang 712082, Peoples R China.
EM xzmylwh@163.com
FU Natural Science Foundation Tibetan Autonomous Region of China
   [ZRKX2021000055]; Young Scholar Cultivation Project of Xizang Minzu
   University [20MDX02]; Youth Program of the Tibet Natural Science
   Foundation [XZ202001ZR0053G]; Xizang Minzu University 2020 College
   Students' Innovation and Entrepreneurship Training Program
   [202010695029]; Natural Science Project of Education Department of
   Shaanxi Provincial Government [21JK0948]
FX This work was supported by the Natural Science Foundation Tibetan
   Autonomous Region of China (Grant no. ZRKX2021000055) , the Young
   Scholar Cultivation Project of Xizang Minzu University (Grant no.
   20MDX02) , the Youth Program of the Tibet Natural Science Foundation
   (Grant no. XZ202001ZR0053G) , and Xizang Minzu University 2020 College
   Students' Innovation and Entrepreneurship Training Program (Grant no.
   202010695029) , the Natural Science Project of Education Department of
   Shaanxi Provincial Government (Grant no. 21JK0948) .
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PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2021
VL 142
AR 111949
DI 10.1016/j.biopha.2021.111949
EA JUL 2021
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UR7OV
UT WOS:000696934800004
PM 34325302
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mir, MA
   Ahmad, W
   Andrews, K
   Kukretee, N
AF Mir, M. Amin
   Ahmad, Waseem
   Andrews, Kim
   Kukretee, Nupur
TI Chemical Synthesis, Experimental, Molecular Docking and Drug-likeness
   Studies of Salidroside
SO ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
LA English
DT Article
DE Salidroside; Chemical synthesis; HPCPC; DFT; Drug-likeness
ID INTERNAL-CONVERSION; ELECTROPHILICITY; PURIFICATION; DESCRIPTOR
AB The compound salidroside was synthesized through the glucosylation of p-tyrosol. This research prioritizes the purification of salidroside over process optimization due to insufficient product yield. High-performance centrifugal partition chromatography (HPCP) with biphasic solid-phase extraction on graphitic material is employed to achieve a final product purity of 95%. Salidroside authentication was conducted using ESIMS2 and NMR. The study integrates computational and experimental approaches, employing B3LYP with basis set 6-311++G (d, p) in density functional theory (DFT). Various characterizing instruments, including 1HNMR, IR, UV visible, and others, consistent with AIM theory (atoms in molecules) for ellipticity and experimental outcomes, are utilized. Donor-acceptor interactions are explored through NBO research. The calculated energy difference between the frontier molecular HOMO and LUMO orbitals indicates the stability of salidroside. Molecular docking studies and electrophilicity index evaluations reveal salidroside's interactions with binding proteins, ranging from 5.718 to 7.405 kcal/mol. Molecular dynamics simulations assess biomolecular stability. Drug-likeness tests suggest salidroside's antibiotic properties, exhibiting similarities with capsaicin, methylsalicylate, menthol, allantoin, lupeol, morphine, and mitragynine. This research contributes valuable scientific insights essential for innovative drug development.
C1 [Mir, M. Amin; Andrews, Kim] Prince Mohammad Bin Fahd Univ, Dept Math & Nat Sci, Al Khobar, Saudi Arabia.
   [Ahmad, Waseem; Kukretee, Nupur] Graphic Era, Dept Math, Dehra Dun, India.
C3 Prince Mohammad Bin Fahd University; Graphic Era University
RP Mir, MA (corresponding author), Prince Mohammad Bin Fahd Univ, Dept Math & Nat Sci, Al Khobar, Saudi Arabia.
EM mohdaminmir@gmail.com
RI Ahmad, Waseem/AAI-3826-2020
OI Ahmad, Waseem/0000-0001-6670-1051; Kukretee, Nupur/0000-0001-9342-6307;
   Andrews, Kim/0000-0002-0304-9630
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NR 44
TC 6
Z9 7
U1 5
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2193-567X
EI 2191-4281
J9 ARAB J SCI ENG
JI Arab. J. Sci. Eng.
PD JUL
PY 2024
VL 49
IS 7
BP 9451
EP 9466
DI 10.1007/s13369-024-08721-3
EA FEB 2024
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WY2C7
UT WOS:001173091200006
DA 2026-05-27
ER

PT J
AU Jin, HJ
   Pei, L
   Shu, XG
   Yang, X
   Yan, TH
   Wu, Y
   Wei, N
   Yan, HL
   Wang, S
   Yao, CY
   Liu, D
   Tian, Q
   Wang, L
   Lu, YM
AF Jin, Huijuan
   Pei, Lei
   Shu, Xiaogang
   Yang, Xin
   Yan, Tianhua
   Wu, Yan
   Wei, Na
   Yan, Honglin
   Wang, Shan
   Yao, Chengye
   Liu, Dan
   Tian, Qing
   Wang, Lin
   Lu, Youming
TI Therapeutic Intervention of Learning and Memory Decays by Salidroside
   Stimulation of Neurogenesis in Aging
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Learning and memory decays; Salidroside; Neurogenesis; Aging; CREB
ID ELEMENT-BINDING PROTEIN; ADULT HIPPOCAMPAL NEUROGENESIS; SPATIAL-PATTERN
   SEPARATION; DENTATE GYRUS; PROGENITOR CELLS; AGED RATS; OLD-AGE;
   NEURONS; BRAIN; MICE
AB Cognition in all mammals including human beings declines during aging. The cellular events responsible for this decay involve a reduction of neurogenesis in the dentate gyrus. Here, we show that treatment with a nature product from a traditional Chinese medicine, namely salidroside restores the capacity of the dentate gyrus to generate new neurons and intercepts learning and memory decays in mice during aging. We uncover that new neurons in aging mice have functional features of an adult granule neuron by forming excitatory synapses with their putative targeting neurons. Genetic inhibition of synaptic transmission from new neurons abolishes the therapeutic effects of salidroside in behavioral tests. We also identify that salidroside targets CREB transcription for the survival of new neurons in the dentate gyrus of old mice. Thus, salidroside is therapeutically effective against learning and memory decays via stimulation of CREB-dependent functional neurogenesis in aging.
C1 [Jin, Huijuan; Pei, Lei; Yang, Xin; Wei, Na; Yan, Honglin; Wang, Shan; Yao, Chengye; Lu, Youming] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Physiol, Wuhan 430030, Peoples R China.
   [Shu, Xiaogang; Wu, Yan; Wang, Lin] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Translat Med Res Ctr, Wuhan 430022, Peoples R China.
   [Yan, Tianhua] China Pharmaceut Univ, Dept Physiol, 24 Tong Jia Xiang St, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Dan] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Genet, Wuhan 430030, Peoples R China.
   [Jin, Huijuan; Pei, Lei; Shu, Xiaogang; Yang, Xin; Wu, Yan; Wei, Na; Yan, Honglin; Wang, Shan; Yao, Chengye; Liu, Dan; Tian, Qing; Wang, Lin; Lu, Youming] Huazhong Univ Sci & Technol, Inst Brain Res, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; China Pharmaceutical University; Huazhong
   University of Science & Technology; Huazhong University of Science &
   Technology
RP Lu, YM (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Physiol, Wuhan 430030, Peoples R China.; Wang, L (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Translat Med Res Ctr, Wuhan 430022, Peoples R China.; Wang, L; Lu, YM (corresponding author), Huazhong Univ Sci & Technol, Inst Brain Res, Wuhan 430030, Peoples R China.
EM Katelinwang@126.com; lym@hust.edu.cn
RI ; Su, Tianyuan/Y-7054-2019
OI Yang, Xin/0000-0003-1632-2402; 
FU National Natural Science Foundation of China [81130079, 91232302,
   81301165]; China Postdoctoral Science Foundation [2014M552047]
FX The authors greatly thank Ping Zhang (HUST) for drug treatments and
   Ling-Qiang Zhu (HUST) for the comments on this manuscript. This work was
   supported by the National Natural Science Foundation of China (81130079
   YL, 91232302 YL, 81301165 HJ) and China Postdoctoral Science Foundation
   (2014M552047 HJ).
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NR 54
TC 38
Z9 44
U1 0
U2 35
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD MAR
PY 2016
VL 53
IS 2
BP 851
EP 866
DI 10.1007/s12035-014-9045-6
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DD8OS
UT WOS:000370187100006
PM 25520005
DA 2026-05-27
ER

PT J
AU Shati, AA
AF Shati, Ali A.
TI Salidroside ameliorates diabetic nephropathy in rats by activating renal
   AMPK/SIRT1 signaling pathway
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE AMPK; diabetic nephropathy; Salidroside; SIRT1; T1DM
ID INDUCED OXIDATIVE STRESS; PROTEIN-KINASE; INSULIN-RESISTANCE; HIGH
   GLUCOSE; KIDNEY-DISEASE; SIRT1; AMPK; EXPRESSION; TRANSLOCATION;
   PATHOGENESIS
AB This study investigated if the nephroprotective effect of Salidroside T1DM rats involves activation of AMPK/SIRT1. Rats were divided into control or T1DM and treated with vehicle or Salidroside (100 mg/kg) for 56 days. Mesangial cells were cultured in LG or HG media with or without Salidroside (100 mu M/L) for 24 hr. Also, HG + Salidroside-treated cells were pre-incubated with EX-527 or compound C (CC) for 1 hr. With reducing glucose levels, Salidroside improved kidney structure/function in the T1DM rat. It also increased GSH and Bcl-2 levels in control and T1DM rats and inhibited ROS, increased activation of AMPK and nuclear SIRT1, and lowered acetylation of P53 and FOXO-1 in control and T1DM rats and in LG and HG-treated cells. These effects were abolished by EX-527 and CC. Also, CC decreased the nuclear levels of SIRT1. In conclusion, Salidroside attenuates DN in T1DM rats by activation of AMPK and subsequently, SIRT1.
   Practical applications This animal and pre-clinical study shows that Salidroside is able to ameliorate DN in T1DM-induced rats and showed that it mainly acts by a hypoglycemic effect and activation of renal AMPK/SIRT1 axis. Given the wide tissue stimulatory effect of AMPK on peripheral glucose utilization, lipogenesis, and other cell signaling pathways, these data are encouraging to investigate the anti-diabetic effect of glycoside in more clinical trials.
C1 [Shati, Ali A.] KKU, Coll Sci, Dept Biol, Abha, Saudi Arabia.
C3 King Khalid University
RP Shati, AA (corresponding author), KKU, Coll Sci, Dept Biol, Abha, Saudi Arabia.
EM aaalshati@kku.edu.sa
RI Shati, Ali/J-8491-2012
FU Deanship of Scientific Research, King Khalid University
   [R.G.P.1/1440/143]
FX Deanship of Scientific Research, King Khalid University, Grant/Award
   Number: R.G.P.1/1440/143
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NR 57
TC 38
Z9 42
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD APR
PY 2020
VL 44
IS 4
AR e13158
DI 10.1111/jfbc.13158
EA FEB 2020
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA LC0BP
UT WOS:000511365300001
PM 32030786
DA 2026-05-27
ER

PT J
AU Chen, LX
   Wu, YN
   Lv, TY
   Tuo, R
   Xiao, Y
AF Chen, Lixuan
   Wu, Yingnan
   Lv, Tiying
   Tuo, Rui
   Xiao, Yang
TI Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis
   and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4
   signaling
SO REDOX REPORT
LA English
DT Article
DE Salidroside; mesenchymal stem cells; premature ovarian insufficiency;
   ferroptosis; Keap1/Nrf2/GPX4 signaling; redox homeostasis; ovarian
   function; fertility
ID OXIDATIVE STRESS; SURVIVAL; DEATH; ACSL4
AB BackgroundRegenerative medicine researches have shown that mesenchymal stem cells (MSCs) may be an effective treatment method for premature ovarian insufficiency (POI). However, the efficacy of MSCs is still limited.PurposeThis study aims to explain whether salidroside and MSCs combination is a therapeutic strategy to POI and to explore salidroside-enhanced MSCs inhibiting ferroptosis via Keap1/Nrf2/GPX4 signaling.MethodsThe effect of salidroside and MSCs on ovarian granular cells (GCs) was analyzed. After treatment, hormone levels and -fertility of rats were measured. Lipid peroxidation levels, iron deposition and mitochondrial morphology were detected. The genes and proteins of Keap1/Nrf2/GPX4 signaling were examined.ResultsSalidroside and MSCs were found to inhibit cell death of GCs by reducing peroxidation and intracellular ferrous. Salidroside promotes the proliferation of MSCs and supports cell survival in ovary. Salidroside combined with MSCs therapy restored ovarian function, which was better than MSCs monotherapy. Salidroside-enhanced MSCs to inhibit ferroptosis. The results showed activation of the Keap1/Nrf2/GPX4 signaling and an increase in anti-ferroptosis molecule.ConclusionsSalidroside-enhanced MSCs as a ferroptosis inhibitor and provide new therapeutic strategies for POI. The possible mechanisms of MSCs were related to maintaining redox homeostasis via a Keap1/Nrf2/GPX4 signaling.
C1 [Chen, Lixuan; Xiao, Yang] Shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, 128 Shekou Ind Seventh Rd, Shenzhen 518067, Guangdong, Peoples R China.
   [Wu, Yingnan] Guangzhou Med Univ, Translat Med Ctr, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Lv, Tiying; Tuo, Rui; Xiao, Yang] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou Medical University; Guangzhou University of Chinese Medicine
RP Xiao, Y (corresponding author), Shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, 128 Shekou Ind Seventh Rd, Shenzhen 518067, Guangdong, Peoples R China.
EM jdxiao111@163.com
RI Lv, Tiying/OZF-3564-2025
FU Shenzhen Qianhai Shekou Pilot Free Trade Zone Hospital
   [ZMQYNXM-2022002]; Foshan Municipal Science and Technology Bureau 2020
   Foshan Municipal Science and Technology Research Project
   [2020001006077]; Special funding Fund for Clinical Scientific Research
   of Wu Jieping Medical Foundation [320.6750.2021-04-43]; Regional Joint
   Fund of basic and Applied basic Research Fund of Guangdong Province
   [2019B151520082]
FX This research was supported by the horizontal scientific research
   project of Shenzhen Qianhai Shekou Pilot Free Trade Zone Hospital (grant
   number ZMQYNXM-2022002); Foshan Municipal Science and Technology Bureau
   2020 Foshan Municipal Science and Technology Research Project (grant
   number 2020001006077); Special funding Fund for Clinical Scientific
   Research of Wu Jieping Medical Foundation (grant number 320.6750.
   2021-04-43) and the Regional Joint Fund of basic and Applied basic
   Research Fund of Guangdong Province (grant number 2019B151520082).
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U2 56
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD DEC 31
PY 2025
VL 30
IS 1
AR 2455914
DI 10.1080/13510002.2025.2455914
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA T8H6K
UT WOS:001407352200001
PM 39874130
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhong, ZF
   Han, J
   Zhang, JZ
   Xiao, Q
   Hu, J
   Chen, LD
AF Zhong, Zhifeng
   Han, Jing
   Zhang, Jizhou
   Xiao, Qing
   Hu, Juan
   Chen, Lidian
TI Pharmacological activities, mechanisms of action, and safety of
   salidroside in the central nervous system
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE salidroside; Alzheimer's disease; Parkinson's disease; stroke; cognitive
   impairment; clinical trials
ID RHODIOLA-ROSEA L.; MAJOR DEPRESSIVE DISORDER; MESENCHYMAL STEM-CELLS;
   INDUCED RAT MODEL; LOW-DOSE REGIMEN; ALZHEIMERS-DISEASE; PC12 CELLS;
   COGNITIVE IMPAIRMENT; INDUCED APOPTOSIS; OXIDATIVE STRESS
AB The primary objective of this review article was to summarize comprehensive information related to the neuropharmacological activity, mechanisms of action, toxicity, and safety of salidroside in medicine. A number of studies have revealed that salidroside exhibits neuroprotective activities, including anti-Alzheimer's disease, anti-Parkinson's disease, anti-Huntington's disease, anti-stroke, anti-depressive effects, and anti-traumatic brain injury; it is also useful for improving cognitive function, treating addiction, and preventing epilepsy. The mechanisms underlying the potential protective effects of salidroside involvement are the regulation of oxidative stress response, inflammation, apoptosis, hypothalamus-pituitary-adrenal axis, neurotransmission, neural regeneration, and the cholinergic system. Being free of side effects makes salidroside potentially attractive as a candidate drug for the treatment of neurological disorders. It is evident from the available published literature that salidroside has potential use as a beneficial therapeutic medicine with high efficacy and low toxicity to the central nervous system. However, the definite target protein molecules remain unclear, and clinical trials regarding this are currently insufficient; thus, guidance for further research on the molecular mechanisms and clinical applications of salidroside is urgent.
C1 [Zhong, Zhifeng; Han, Jing; Zhang, Jizhou; Xiao, Qing; Hu, Juan; Chen, Lidian] Fujian Acad Tradit Chinese Med Fuzhou, Inst Materia Med, 282 Wusi Rd, Fuzhou 350003, Fujian, Peoples R China.
   [Hu, Juan; Chen, Lidian] Fujian Univ Tradit Chinese Med, Sch Rehabil Med, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Hu, J; Chen, LD (corresponding author), Fujian Acad Tradit Chinese Med Fuzhou, Inst Materia Med, 282 Wusi Rd, Fuzhou 350003, Fujian, Peoples R China.
EM huj@fjtcm.edu.cn; cld@fjtcm.edu.cn
RI ; Chen, Lidian/GSN-6461-2022; Zhang, Jizhou/N-8928-2019
OI Zhong, Zhifeng/0000-0003-2793-6178; Chen, Lidian/0000-0002-8699-0839;
   Zhang, Jizhou/0000-0002-8831-501X; Han, Jing/0000-0002-7142-1991
FU Fujian Provincial Health and Family Planning Commission [2017-1-80];
   project of Fujian Province Office of Education [JZ160442]; Fujian
   Provincial Science and Technology Department [2018R1035-9, 2018R1035-11]
FX This work was supported by the research project of Fujian Provincial
   Health and Family Planning Commission (2017-1-80), the project of Fujian
   Province Office of Education (JZ160442), and Fujian Provincial Science
   and Technology Department (2018R1035-9), and Fujian Provincial Science
   and Technology Department (2018R1035-11).
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NR 97
TC 108
Z9 128
U1 0
U2 69
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2018
VL 12
BP 1479
EP 1489
DI 10.2147/DDDT.S160776
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GH2CK
UT WOS:000433209000006
PM 29872270
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, XB
   Xu, BB
   Zhang, MD
   Yao, XL
   Xu, K
   Gao, FY
AF Yu, Xiaobo
   Xu, Binbin
   Zhang, Mingdong
   Yao, Xuelian
   Xu, Kun
   Gao, Fengying
TI Salidroside inhibits the ferroptosis to alleviate lung ischemia
   reperfusion injury via the JAK2/STAT3 signalling pathway
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Lung ischemia reperfusion injury (LIRI); Ferroptosis; Salidroside;
   JAK2/STAT3
ID INFLAMMATION
AB Objective: The present study aims to investigate the protective potential of salidroside in both lung ischemia/ reperfusion injury (LIRI) mice model and cell hypoxia/reoxygenation (H/R)model and the involvement of ferroptosis and JAK2/STAT3 pathway. Materials and methods: After we established the IR-induced lung injury model in mice, we administered salidroside and the ferroptosis inhibitor, ferrostatin-1, then assessed the lung tissue injury, ferroptosis (levels of reactive oxygen species level, malondialdehyde and glutathione), and inflammation in lung tissues. The levels of ferroptosis-related proteins (glutathione peroxidase 4, fibroblast-specific protein 1, solute carrier family 1 member 5 and glutaminase 2) in the lung tissue were measured with Western blotting. Next, BEAS-2B cells were used to establish an H/R cell model and treated with salidroside or ferrostatin-1 before the cell viability and the levels of lactate dehydrogenase (LDH), inflammatory factor, ferroptosis-related proteins were measured. The activation of the JAK2/STAT3 signaling pathway was measured with Western blotting, then its role was confirmed with STAT3 knockdown. Results: Remarkably, salidroside was found to alleviate ferroptosis, inflammation, and lung injury in LIRI mice and the cell injury in H/R cell model. Severe ferroptosis were observed in LIRI mice models and H/R-induced BEAS-2B cells, which was alleviated by salidroside. Furthermore, salidroside could inhibit JAK2/STAT3 activation induced by LIRI. STAT3 knockdown could enhance the effect of salidroside treatment on H/R-induced cell damage and ferroptosis in vitro. Conclusions: Salidroside inhibits ferroptosis to alleviate lung ischemia reperfusion injury via the JAK2/STAT3 signaling pathway.
C1 [Yu, Xiaobo] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Thorac Surg, 100 Haining Rd, Shanghai 200080, Peoples R China.
   [Xu, Binbin; Zhang, Mingdong; Yao, Xuelian; Xu, Kun] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Thorac Surg,Jiading Branch, 800 Huangjiahuayuan Rd, Shanghai 201803, Peoples R China.
   [Gao, Fengying] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Pulm Dis, 274 ZhiJiang Middle Rd, Shanghai 200071, Peoples R China.
   [Gao, Fengying] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Pulm Dis, 274 ZhiJiang middle Rd, Shanghai 200071, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   University of Traditional Chinese Medicine; Shanghai University of
   Traditional Chinese Medicine
RP Gao, FY (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Pulm Dis, 274 ZhiJiang middle Rd, Shanghai 200071, Peoples R China.
EM fengyinggao@outlook.com
RI Xu, Kun/NBY-1251-2025
FU Scientific Research Projects of Shanghai Municipal Health and Family
   Planning Commission [201840263]
FX This study was supported by Scientific Research Projects of Shanghai
   Municipal Health and Family Planning Commission (No. 201840263) .
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TC 9
Z9 12
U1 1
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 30
PY 2024
VL 722
AR 150132
DI 10.1016/j.bbrc.2024.150132
EA MAY 2024
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA UD7D0
UT WOS:001246180000001
PM 38788354
DA 2026-05-27
ER

PT J
AU Vasileva, LV
   Saracheva, KE
   Ivanovska, MV
   Petrova, AP
   Marchev, AS
   Georgiev, MI
   Murdjeva, MA
   Getova, DP
AF Vasileva, Liliya V.
   Saracheva, Kremena E.
   Ivanovska, Mariya, V
   Petrova, Atanaska P.
   Marchev, Andrey S.
   Georgiev, Milen, I
   Murdjeva, Mariana A.
   Getova, Damiyanka P.
TI Antidepressant-like effect of salidroside and curcumin on the
   immunoreactivity of rats subjected to a chronic mild stress model
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Salidroside; Curcumin; Fluoxetine; Chronic mild stress;
   Immunoreactivity; LPS-Induced inflammation
ID DEPRESSIVE-LIKE BEHAVIOR; COGNITIVE DYSFUNCTION; FLUOXETINE;
   INVOLVEMENT; DEFICITS; EXTRACT; IMPAIRMENT; EXPRESSION; CYTOKINES;
   DISORDER
AB Deregulated cytokines' production is found in depressed patients. Salidroside and curcumin both have been described with potential antidepressant-like activities. The present study investigated the effect of pure salidroside, curcumin and their combination on the immunoreactivity of animals, subjected to a chronic mild stress (CMS) model, followed by lipopolysaccharide (LPS)-induced inflammation. Wistar male rats were separated in the following six groups: control, CMS model, fluoxetine (2.5 mg/kg, oral), salidroside (5 mg/kg, oral), curcumin (20 mg/kg, oral) and salidroside + curcumin (5 mg/kg + 20 mg/kg, oral). Changes in glucose preference, spatial learning and exploratory behavior were recorded. The IL-6 levels in the rate sera and of the TNF-alpha levels in the rate sera and the brain tissue homogenate were evaluated. The groups exposed to stress and treated with fluoxetine, salidroside, curcumin or salidroside + curcumin showed increase in the glucose preference and locomotor activity, as well as, decrease in the escape latency and the cytokines' levels compared to the CMS model group. The chronic stress induced behavioral alternations and increased cytokines' levels in rats which were reversed by administration of salidroside and curcumin, suggesting antidepressant-like effects comparable to that of fluoxetine and potential synergistic interaction regarding the anti-inflammatory and anti-stress effects.
C1 [Vasileva, Liliya V.; Saracheva, Kremena E.] Med Univ Plovdiv, Fac Pharm, Dept Pharmacol & Drug Toxicol, Plovdiv 4000, Bulgaria.
   [Ivanovska, Mariya, V; Petrova, Atanaska P.; Murdjeva, Mariana A.] Med Univ Plovdiv, Fac Pharm, Dept Microbiol & Immunol, Plovdiv 4000, Bulgaria.
   [Ivanovska, Mariya, V; Murdjeva, Mariana A.] Technol Ctr Emergency Med TCEMED, Div Immunol Assessment Posttraumat Stress Disorde, Plovdiv, Bulgaria.
   [Marchev, Andrey S.; Georgiev, Milen, I] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Grp Plant Cell Biotechnol & Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Vasileva, Liliya V.; Marchev, Andrey S.; Georgiev, Milen, I] Ctr Plant Syst Biol & Biotechnol, Plovdiv 4000, Bulgaria.
   [Getova, Damiyanka P.] Technol Ctr Emergency Med TCEMED, Lab Expt Neuropharmacol, Plovdiv 4000, Bulgaria.
C3 Medical University Plovdiv; Medical University Plovdiv; Bulgarian
   Academy of Sciences; Stephan Angeloff Institute of Microbiology,
   Bulgarian Academy of Sciences
RP Vasileva, LV (corresponding author), Med Univ Plovdiv, Fac Pharm, Dept Pharmacol & Drug Toxicol, Plovdiv 4000, Bulgaria.
RI Petrova, Atanaska/GZA-8788-2022; Georgiev, Milen I/P-6948-2015;
   Mihaylova, Liliya/I-6017-2016; Ivanovska, Mariya/AFC-6874-2022; Marchev,
   Andrey/PFR-2450-2026
OI Petrova, Atanaska/0000-0001-7254-7265; Marchev,
   Aney/0000-0002-7660-683X; Georgiev, Milen I/0000-0001-5248-6135;
   Mihaylova, Liliya/0000-0002-1690-1490; Ivanovska,
   Mariya/0000-0001-9028-2192; Murdjeva, Marianna/0000-0002-1357-6717
FU European Union's Horizon 2020 research and innovation programme
   [PlantaSYST - SGA/CSA: 739582, FPA: 664620]; Medical University of
   Plovdiv [SDP15/2015]
FX The project for establishment of CPSBB has received funding from the
   European Union's Horizon 2020 research and innovation programme under
   grant agreement No PlantaSYST - SGA/CSA: 739582 - under FPA: 664620.The
   authors declare that this work was supported by a grant from the Medical
   University of Plovdiv - Project SDP15/2015.
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NR 52
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U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD NOV
PY 2018
VL 121
BP 604
EP 611
DI 10.1016/j.fct.2018.09.065
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA GZ2UB
UT WOS:000449242800066
PM 30268794
DA 2026-05-27
ER

PT J
AU Sun, HP
   Tang, X
   Zhang, YY
   Fu, XN
   Wang, RX
   Shahzaib, M
   Qiao, F
AF Sun, Huapeng
   Tang, Xin
   Zhang, Yingying
   Fu, Xiaona
   Wang, Rongxiang
   Shahzaib, Muhammad
   Qiao, Fei
TI Engineering and Optimization of the Salidroside Production in Tobacco
   Cells by Reconstructed Biosynthetic Genes from Rhodiola rosea
SO ACS SYNTHETIC BIOLOGY
LA English
DT Article
DE salidroside; reconstruction; heterologous production; tobacco cells;
   endogenous <sc>l</sc>-tyrosine
ID 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE; SHIKIMATE PATHWAY;
   METABOLITES; NICOTINE
AB Salidroside, a tyrosine-derived bioactive product, originates from the Rhodiola genus and has various medicinal properties. However, the surge in global demand requires exploration of more efficient and sustainable approaches to produce salidroside. This study reconstructed three functional enzymes in tobacco cells to produce salidroside using endogenous l-tyrosine. Under the optimized two-stage protocol (1% sucrose in the production medium; 11 days of culture), salidroside accumulation reached a maximum of 377.53 mu g per gram of HHU cells in fresh weight. Neither precursor feeding (100 mg/L shikimate) nor various elicitors (e.g., MeJA, SA, and ABA) provided any further enhancement. Comparative transcriptomic analysis revealed that two DAHPS transcripts (107797958 and 107817203) were upregulated more than 2-fold, indicating that the reconstructed pathway boosts endogenous l-tyrosine flux, and elicitation and precursor feeding strategies could not enhance salidroside accumulation. Meanwhile, comparative transcriptomic analysis revealed that the reconstructed pathway could upregulate crucial gene expression in endogenous l-tyrosine biosynthesis. This study evaluates tobacco cells as biofactories to produce salidroside and lays the foundation for the biosynthesis engineering of other heterologous metabolites.
C1 [Sun, Huapeng; Tang, Xin; Zhang, Yingying; Fu, Xiaona; Wang, Rongxiang; Shahzaib, Muhammad; Qiao, Fei] Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Natl Key Lab Trop Crop Breeding, Key Lab Crop Gene Resources & Germplasm Enhancemen, Haikou 571101, Peoples R China.
C3 Chinese Academy of Tropical Agricultural Sciences
RP Qiao, F (corresponding author), Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Natl Key Lab Trop Crop Breeding, Key Lab Crop Gene Resources & Germplasm Enhancemen, Haikou 571101, Peoples R China.
EM fei.qiao@foxmail.com
RI ; Tang, Xin/GPP-4511-2022; Qiao, Fei/PHF-2779-2026
OI Shahzaib, Muhammad/0000-0001-5082-2748; 
FU National Key Research and Development Program of China [2023YFA0915800];
   National Key Research and Development Program of China
   [CATASCXTD202413]; Chinese Academy of Tropical Agricultural Sciences for
   Science and Technology Innovation Team of National Tropical Agricultural
   Science Center [KJRC2023C29]; Innovational Fund for Scientific and
   Technological Personnel of Hainan Province
FX This study was supported by the National Key Research and Development
   Program of China (Grant No. 2023YFA0915800), Chinese Academy of Tropical
   Agricultural Sciences for Science and Technology Innovation Team of
   National Tropical Agricultural Science Center (NO. CATASCXTD202413) and
   Innovational Fund for Scientific and Technological Personnel of Hainan
   Province (Grant No. KJRC2023C29). The authors thank Prof. Daizhu Lv for
   technical assistance with the HPLC-MS/MS analysis.
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NR 41
TC 0
Z9 0
U1 5
U2 10
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2161-5063
J9 ACS SYNTH BIOL
JI ACS Synth. Biol.
PD JUN 24
PY 2025
VL 14
IS 7
BP 2788
EP 2796
DI 10.1021/acssynbio.5c00185
EA JUN 2025
PG 9
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5BP1V
UT WOS:001519011000001
PM 40555678
DA 2026-05-27
ER

PT J
AU Wang, XH
   Zuo, ZF
   Meng, L
   Yang, Q
   Lv, P
   Zhao, LP
   Wang, XB
   Wang, YF
   Huang, Y
   Fu, C
   Liu, WQ
   Liu, XZ
   Zheng, DY
AF Wang, Xue-Hua
   Zuo, Zhong-Fu
   Meng, Lu
   Yang, Qi
   Lv, Pan
   Zhao, Li-Pan
   Wang, Xiao-Bai
   Wang, Yu-Fei
   Huang, Ying
   Fu, Cong
   Liu, Wen-Qiang
   Liu, Xue-Zheng
   Zheng, De-Yu
TI Neuroprotective effect of salidroside on hippocampal neurons in diabetic
   mice via PI3K/Akt/GSK-3β signaling pathway
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Diabetes mellitus; PI3K/Akt/GSK-3 beta; The hippocampal neuron; Learning
   and memory salidroside
ID COGNITIVE IMPAIRMENT; GROWTH-FACTOR; ACTIVATION; BRAIN; STREPTOZOTOCIN;
   SURVIVAL; ENCEPHALOPATHY; MELLITUS; INJURY; TYPE-2
AB Background Diabetic encephalopathy is manifested by cognitive dysfunction. Salidroside, a nature compound isolated from Rhodiola rosea L, has the effects of anti-inflammatory and antioxidant, hypoglycemic and lipid-lowering, improving insulin resistance, inhibiting cell apoptosis, and protecting neurons. However, the mechanism by which salidroside alleviates neuronal degeneration and improves learning and memory impairment in diabetic mice remains unclear. Objective To investigate the effects and mechanisms of salidroside on hippocampal neurons in streptozotocin-induced diabetic mice. Materials and methods C57BL/6 mice were randomly divided into 4 groups to receive either sham (control group (CON)), diabetes mellitus (diabetes group (DM)), diabetes mellitus + salidroside (salidroside group (DM + SAL)), and diabetes mellitus + salidroside + phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (diabetes mellitus + salidroside + LY294002 group (DM + SAL + LY294002)). After 12 weeks of diabetes onset, the cognitive behaviors were tested using Morris water maze. The number of hippocampal neurons was detected by Nissl staining. The expressions of PI3K, p- PI3K, Akt, p-Akt, GSK-3 beta, p-GSK-3 beta, cleaved caspase-3, caspase-3, Bax, Bcl-2, MAP2, and SYN in the hippocampus were detected by Western blot. Moreover, the expression of MAP2 and SYN in the hippocampus was further confirmed by immunofluorescence staining. Results Salidroside increased the time of diabetic mice in the platform quadrant and reduced the escape latency of diabetic mice. Salidroside also increased the expression of p-PI3K, p-Akt, p-GSK-3 beta, MAP2, SYN, Bcl- 2, while suppressed the expression of cleaved caspase-3, caspase3, and Bax in the DM + SAL group compared with the DM group (P < 0.05). The Nissl staining showed that the number of hippocampus neurons in the DM + SAL group was increased with the intact, compact, and regular arrangement, compared with the DM groups (P < 0.05). Interestingly, the protective effects of salidroside on diabetic cognitive dysfunction, hippocampal morphological alterations, and protein expressions were abolished by inhibition of PI3K with LY294002. Conclusions Salidroside exerts neuroprotective properties in diabetic cognitive dysfunction partly via activating the PI3K/ Akt/GSK-3 beta signaling pathway.
C1 [Wang, Xue-Hua; Zuo, Zhong-Fu; Meng, Lu; Yang, Qi; Lv, Pan; Zhao, Li-Pan; Wang, Xiao-Bai; Wang, Yu-Fei; Huang, Ying; Fu, Cong; Liu, Wen-Qiang; Liu, Xue-Zheng; Zheng, De-Yu] Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121001, Liaoning, Peoples R China.
   [Zuo, Zhong-Fu; Liu, Xue-Zheng] Jinzhou Med Univ, Liaoning Key Lab Diabet Cognit & Percept Dysfunct, Jinzhou 121001, Liaoning, Peoples R China.
   [Zuo, Zhong-Fu] Guangxi Med Univ, Dept Anat Histol & Embryol, Postdoctoral Res Stn, Nanning 530021, Guangxi, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University; Guangxi Medical
   University
RP Liu, XZ; Zheng, DY (corresponding author), Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121001, Liaoning, Peoples R China.; Liu, XZ (corresponding author), Jinzhou Med Univ, Liaoning Key Lab Diabet Cognit & Percept Dysfunct, Jinzhou 121001, Liaoning, Peoples R China.
EM Liu163@vip.sina.com; zdy4673349@163.com
FU China Postdoctoral Science Foundation [2017M612870]; Natural Science
   Foundation of Liaoning Province [2019-ZD-0807]
FX This study was supported by China Postdoctoral Science Foundation (No.
   2017M612870) and Natural Science Foundation of Liaoning Province (No.
   2019-ZD-0807)
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NR 48
TC 15
Z9 21
U1 1
U2 24
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD SEP
PY 2023
VL 240
IS 9
BP 1865
EP 1876
DI 10.1007/s00213-023-06373-z
EA JUL 2023
PG 12
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA Q7UP0
UT WOS:001036656600001
PM 37490132
DA 2026-05-27
ER

PT J
AU Chen, DH
   Zhou, KL
   Weng, WD
   Jin, HM
   Xu, DL
   Cai, NY
   Xu, HZ
AF Chen Deheng
   Zhou Kailiang
   Weng Weidong
   Jin Haiming
   Xu Daoliang
   Cai Ningyu
   Xu Huazi
TI Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing
   Angiogenesis and Inhibiting Apoptosis
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE salidroside; random flap survival; angiogenesis; inflammation; apoptosis
ID ISCHEMIA-REPERFUSION INJURY; PATHWAY; ACTIVATION; PROTEINS; CELLS; MODEL
AB Background Flap necrosis is frequently observed in flap transfer operations. Salidroside has been reported to reduce cell apoptosis by alleviating inflammation and oxidative stress. We investigated the effects of salidroside on the survival of random skin flaps.
   Materials and Methods The McFarlane flap model was established in 80 rats that were divided into two groups and administered salidroside or saline solution intraperitoneally over 7 days. The area of necrosis and the extent of tissue edema were measured. Angiogenesis was assessed via lead oxide-gelatin angiography, immunohistochemistry for CD34, and VEGF expression. Cell apoptosis was evaluated by expression of cleaved caspase 3, caspase 3, Bax, and Bcl-2. The inflammatory response was evaluated using an ELISA kit for TNF-alpha and IL-6 in serum. Oxidative stress was assessed by measuring the activity of superoxide dismutase (SOD) and the level of malondialdehyde (MDA).
   Results Compared with controls, salidroside-treated flaps featured a greater area of surviving tissue and less edema. It also promoted the expression of VEGF and increased skin flap angiogenesis. Cell apoptosis, inflammation reaction, and oxidative stress were significantly attenuated in the salidroside group.
   Conclusion Salidroside has a positive effect on improving random skin flap survival.
C1 [Chen Deheng; Zhou Kailiang; Weng Weidong; Jin Haiming; Xu Daoliang; Cai Ningyu; Xu Huazi] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Wenzhou, Peoples R China.
   [Chen Deheng; Zhou Kailiang; Weng Weidong; Jin Haiming; Xu Daoliang; Cai Ningyu; Xu Huazi] Wenzhou Med Univ, Clin Med Coll 2, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Xu, HZ (corresponding author), 109 XueYuan Rd West, Wenzhou, Zhejiang, Peoples R China.
EM spinexu@163.com
RI Jin, Haiming/LZE-3453-2025
FU National Natural Science foundation of China [81572227]; Wenzhou science
   and technology plan project [Y20140569]; Zhejiang provincial medical and
   health technology project [2015KYA138]
FX This study was supported by National Natural Science foundation of China
   (81572227), Wenzhou science and technology plan project funding
   (NO.Y20140569), and Zhejiang provincial medical and health technology
   project funding (NO.2015KYA138).
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NR 30
TC 35
Z9 37
U1 0
U2 11
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD OCT
PY 2016
VL 32
IS 8
BP 580
EP 586
DI 10.1055/s-0036-1584205
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DW0CG
UT WOS:000383307900002
PM 27276197
DA 2026-05-27
ER

PT J
AU Xiao, LY
   Li, HF
   Zhang, J
   Yang, F
   Huang, AZ
   Deng, JJ
   Liang, M
   Ma, FL
   Hu, MH
   Huang, ZB
AF Xiao, Lingyun
   Li, Haifeng
   Zhang, Ju
   Yang, Fan
   Huang, Aizhen
   Deng, Jingjing
   Liang, Ming
   Ma, Fangli
   Hu, Minghua
   Huang, Zebo
TI Salidroside Protects Caenorhabditis elegans Neurons from
   Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress
SO MOLECULES
LA English
DT Article
DE salidroside; polyglutamine; neurotoxicity; oxidative stress; C. elegans;
   chemoavoidance
ID ALZHEIMERS-DISEASE; AGGREGATION; DAMAGE; INHIBITION; EXTRACTS; EVENTS
AB Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of Huntington's disease and other polyQ disorders. Therefore, strategies aiming at restoring dysfunction and reducing stresses mediated by polyQ toxicity are of therapeutic interest for proteotoxicity diseases. Salidroside, a glycoside from Rhodiola rosea, has been shown to have a variety of bioactivities, including antioxidant activity. Using transgenic Caenorhabditis elegans models, we show here that salidroside is able to reduce neuronal death and behavioral dysfunction mediated by polyQ expressed in ASH neurons, but the neuroprotective effect is not associated with prevention of polyQ aggregation per se. Further experiments reveal that the neuroprotective effect of salidroside in C. elegans models involves its antioxidant capabilities, including decrease of ROS levels and paraquat-induced mortality, increase of antioxidant enzyme activities and reduction of lipid peroxidation. These results demonstrate that salidroside exerts its neuroprotective function against polyQ toxicity via oxidative stress pathways.
C1 [Xiao, Lingyun; Li, Haifeng; Zhang, Ju; Yang, Fan; Deng, Jingjing; Huang, Zebo] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.
   [Li, Haifeng; Liang, Ming; Ma, Fangli; Hu, Minghua] Infinitus China Co Ltd, Ctr Res & Dev, Guangzhou 510665, Guangdong, Peoples R China.
   [Zhang, Ju; Huang, Aizhen; Huang, Zebo] Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Guangdong Prov Key Lab Biotechnol Drug Candidates, Guangzhou 510006, Guangdong, Peoples R China.
C3 Wuhan University; Guangdong Pharmaceutical University
RP Huang, ZB (corresponding author), Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.
EM xiaolingyun@whu.edu.cn; lhf@whu.edu.cn; juzi437163804@163.com;
   yangfan6616@126.com; haz0709@163.com; cjhsusan@whu.edu.cn;
   fiona.liang@infinitus-int.com; mary.ma@infinitus-int.com;
   mandy.hu@infinitus-int.com; zebohuang@gdpu.edu.cn
RI Huang, Zebo/GRR-2009-2022; Zhang, Dabing/AAR-6473-2020
OI Huang, Zebo/0000-0003-2431-3741; Xiao, Lingyun/0009-0000-7101-0933; 
FU National Natural Science Foundation of China [81274048]; Guangdong
   Provincial Department of Science and Technology [2012B090600025];
   Fundamental Research Funds for the Central Universities [2012306020205,
   20103060101000167]; China Postdoctoral Science Foundation [2014M552086]
FX This work was supported by the National Natural Science Foundation of
   China (Grant 81274048), Guangdong Provincial Department of Science and
   Technology (Grant 2012B090600025), the Fundamental Research Funds for
   the Central Universities (Grants 2012306020205 and 20103060101000167),
   and China Postdoctoral Science Foundation (Grant 2014M552086).
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NR 40
TC 59
Z9 64
U1 0
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUN
PY 2014
VL 19
IS 6
BP 7757
EP 7769
DI 10.3390/molecules19067757
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AK7DP
UT WOS:000338586700051
PM 24918543
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Qian, DF
   Dong, Y
   Liu, XL
   Yu, HC
   Song, ZL
   Jia, CQ
   Zhang, Z
   Cao, SQ
   Hu, FQ
   Zhang, XS
AF Qian, Dingfei
   Dong, Yuan
   Liu, Xiaole
   Yu, Haichao
   Song, Zelong
   Jia, Chengqi
   Zhang, Zhen
   Cao, Shiqi
   Hu, Fanqi
   Zhang, Xuesong
TI Salidroside promotes the repair of spinal cord injury by inhibiting
   astrocyte polarization, promoting neural stem cell proliferation and
   neuronal differentiation
SO CELL DEATH DISCOVERY
LA English
DT Article
ID TRANSPLANTATION; PATHWAY
AB Spinal cord injury (SCI) remains a formidable challenge, lacking effective treatments. Following SCI, neural stem cells (NSCs) migrate to SCI sites, offering a potential avenue for nerve regeneration, but the effectiveness of this intrinsic repair mechanism remains suboptimal. Salidroside has demonstrated pro-repair attributes in various pathological conditions, including arthritis and cerebral ischemia, and the ability to curtail early-stage inflammation following SCI. However, the specific role of salidroside in the late-stage repair processes of SCI remains less defined. In this investigation, we observed that continuous salidroside treatment in SCI mice improved motor function recovery. Immunofluorescence-staining corroborated salidroside's capacity to stimulate nerve regeneration and remyelination, suppress glial scar hyperplasia, reduce the activation of neurotoxic A1 astrocytes, and facilitate NSCs migration towards the injured region. Mechanistically, in vitro experiments elucidated salidroside's significant role in restraining astrocyte proliferation and A1 polarization. It was further established that A1 astrocytes hinder NSCs proliferation while inducing their differentiation into astrocytes. Salidroside effectively ameliorated this inhibition of NSCs proliferation through diminishing c-Jun N-terminal kinase (JNK) pathway phosphorylation and restored their differentiation into neurons by suppressing the signal transducer and activator of transcription 3 (STAT3) pathway. In summary, our findings suggest that salidroside holds promise as a therapeutic agent for traumatic SCI treatment.
C1 [Qian, Dingfei; Dong, Yuan; Liu, Xiaole; Yu, Haichao; Song, Zelong; Zhang, Zhen; Cao, Shiqi; Hu, Fanqi; Zhang, Xuesong] Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Qian, Dingfei; Dong, Yuan; Liu, Xiaole; Yu, Haichao; Song, Zelong; Zhang, Zhen; Cao, Shiqi; Hu, Fanqi; Zhang, Xuesong] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, 51 Fucheng Rd, Beijing 100048, Peoples R China.
   [Qian, Dingfei] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
   [Qian, Dingfei] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China.
   [Jia, Chengqi] Capital Med Univ, Beijing Jishuitan Hosp, Dept Orthoped, Beijing 100035, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese Academy of Sciences; National
   Center for Nanoscience & Technology, CAS; Key Laboratory for Biological
   Effects of Nanomaterials & Nanosafety, CAS; Chinese Academy of Sciences;
   National Center for Nanoscience & Technology, CAS; Capital Medical
   University
RP Cao, SQ; Hu, FQ; Zhang, XS (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, 28 Fuxing Rd, Beijing 100853, Peoples R China.; Cao, SQ; Hu, FQ; Zhang, XS (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, 51 Fucheng Rd, Beijing 100048, Peoples R China.
EM sq_cao@126.com; hufanqi301@163.com; Zhangxuesong301@126.com
RI Jia, Chengqi/HLQ-0374-2023; Yu, Haichao/LRU-5027-2024
FU National Natural Science Foundation of China (National Science
   Foundation of China)
FX No Statement Available
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NR 64
TC 12
Z9 15
U1 1
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2058-7716
J9 CELL DEATH DISCOV
JI Cell Death Discov.
PD MAY 9
PY 2024
VL 10
IS 1
AR 224
DI 10.1038/s41420-024-01989-2
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA PY3J9
UT WOS:001217598100001
PM 38724500
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, XJ
   Zhang, XX
   Wang, D
   Luo, RS
   Qin, Z
   Lin, FZ
   Xia, X
   Liu, XM
   Hu, G
AF Zhou, Xiaojie
   Zhang, Xiaoxiao
   Wang, Dan
   Luo, Ruoshi
   Qin, Zhao
   Lin, Fanzhen
   Xia, Xue
   Liu, Xuemei
   Hu, Ge
TI Efficient Biosynthesis of Salidroside via Artificial in Vivo
   enhanced UDP-Glucose System Using Cheap Sucrose as Substrate
SO ACS OMEGA
LA English
DT Article
ID ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; BIOCHEMICAL EVALUATION;
   MICROBIAL CONSORTIA; COCULTURE; EVOLUTION; SYNTHASE; REVEALS; PATHWAY;
   SUGAR
AB Salidroside, a valuable phenylethanoid glycoside, is obtained from plants belonging to the Rhodiola genus, known for its diverse biological properties. At present, salidroside is still far from large-scale industrial production due to its lower titer and higher process cost. In this study, we have for the first time increased salidroside production by enhancing UDP-glucose supply in situ. We constructed an in vivo UDP-glucose regeneration system that works in conjunction with UDP-glucose transferase from Rhodiola innovatively to improve UDP-glucose availability. And a coculture was formed in order to enable de novo salidroside synthesis. Confronted with the influence of tyrosol on strain growth, an adaptive laboratory evolution strategy was implemented to enhance the strain's tolerance. Similarly, salidroside production was optimized through refinement of the fermentation medium, the inoculation ratio of the two microbes, and the inoculation size. The final salidroside titer reached 3.8 g/L. This was the highest titer achieved at the shake flask level in the existing reports. And this marked the first successful synthesis of salidroside in an in situ enhanced UDP-glucose system using sucrose. The cost was reduced by 93% due to the use of inexpensive substrates. This accomplishment laid a robust foundation for further investigations into the synthesis of other notable glycosides and natural compounds.
C1 [Zhou, Xiaojie; Wang, Dan; Luo, Ruoshi; Qin, Zhao; Lin, Fanzhen; Xia, Xue; Liu, Xuemei; Hu, Ge] Chongqing Univ, Sch Chem & Chem Engn, Dept Chem Engn, Chongqing 401331, Peoples R China.
   [Zhang, Xiaoxiao] AgroParisTech, F-91120 Palaiseau, France.
C3 Chongqing University; AgroParisTech
RP Wang, D; Hu, G (corresponding author), Chongqing Univ, Sch Chem & Chem Engn, Dept Chem Engn, Chongqing 401331, Peoples R China.
EM dwang@cqu.edu.cn; huge@cqu.edu.cn
OI Wang, Dan/0000-0002-8529-1665; Qin, Zhao/0000-0003-4053-7665
FU National Key Research and Development Program of China [2022YFC2105700,
   2021YFC2103300]; National Natural Science Foundation of China
   [22378032]; Chongqing Outstanding Youth Fund [cstc2021jcyj-jqX0013];
   Youth project of science and technology research program of Chongqing
   Education Commission of China [KJQN201900112]; Human Resources and
   Social Security Bureau of Chongqing [cx2023036]
FX This work received funding from the National Key Research and
   Development Program of China(2022YFC2105700, 2021YFC2103300); the
   National Natural Science Foundation of China(22378032);Chongqing
   Outstanding Youth Fund (cstc2021jcyj-jqX0013),Youth project of science
   and technology research program of Chongqing Education Commission of
   China (KJQN201900112), and the Human Resources and Social Security
   Bureau of Chongqing (cx2023036).
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD MAY 10
PY 2024
VL 9
IS 20
BP 22386
EP 22397
DI 10.1021/acsomega.4c02060
EA MAY 2024
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA RO4B3
UT WOS:001226131100001
PM 38799314
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, XZ
   Wu, YP
   Yang, TH
   Wei, MT
   Wang, YX
   Deng, XB
   Shen, CC
   Li, WT
   Zhang, H
   Xu, WY
   Gou, LT
   Zeng, Y
   Zhang, YH
   Wang, ZQ
   Yang, JL
AF Chen, Xiangzheng
   Wu, Yangping
   Yang, Tinghan
   Wei, Mingtian
   Wang, Yuxi
   Deng, Xiangbing
   Shen, Congcong
   Li, Wenting
   Zhang, Hang
   Xu, Weiyong
   Gou, Lantu
   Zeng, Yong
   Zhang, Yonghui
   Wang, Ziqiang
   Yang, Jinliang
TI Salidroside alleviates cachexia symptoms in mouse models of cancer
   cachexia via activating mTOR signalling
SO JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
LA English
DT Article
DE Salidroside; Cancer-associated cachexia; Skeletal muscle; mTOR; MyHC
ID WEIGHT-LOSS; MECHANISMS; MEDIATORS
AB Background Cachexia has a devastating impact on survival and quality of life for many cancer patients and contributes to nearly one-third of all cancer deaths; also, it is associated with poor responses to chemotherapy and survival. A better understanding of the underlying mechanisms of cancer-associated cachexia (CAC), coupled with effective therapeutic approaches, will improve management of progressive functional impairment in cancer patients. Salidroside, a phenylpropanoid glycoside in Rhodiola rosea L, has been reported to possess potential anti-fatigue, anti-ageing, and anti-Alzheimer's disease properties. It is widely consumed as a nutritional supplement, but its effects on CAC and the possible mechanism remain a mystery.
   Methods In the murine models of cachexia induced by CT-26 and Lewis lung carcinoma (LLC) tumour, respectively, main features of CAC were determined after treatment of salidroside or chemotherapy. In vitro experiments were performed using murine C2C12 myotubes, which were treated by tumour necrosis factor-a. Levels of several critical muscle-related signal proteins such as mammalian target of rapamycin (mTOR), p-mTOR, and myosin heavy chain (MyHC) were examined using western blot both in vitro and in vivo.
   Results In the present study, we showed the exciting effect of salidroside on the treatment of CAC. In CT-26 and LLC models, respectively, salidroside treatment could effectively preserve the tumour-free body weight, decrease loss of adipose and gastrocnemius muscles, alleviate tumour burden, and prolong their survival time. Additionally, in combined chemotherapy, salidroside could synergistically enhance the anti-tumour activity of cisplatin, especially decreased or eliminated chemotherapy-induced cachexia. Further analysis demonstrated that salidroside could significantly increase expression of mTOR, p-mTOR, and MyHC in gastrocnemius muscle. Also, results in vitro showed that salidroside could not only obviously increase mTOR, p-mTOR, and MyHC expression in C2C12 myotubes but also effectively rescue their down-regulation induced by tumour necrosis factor-alpha.
   Conclusions In the current study, the exciting effect of salidroside on CAC suggested that salidroside supplementation might be a promising approach for a multi-targeted therapy for the treatment of CAC.
C1 [Chen, Xiangzheng; Yang, Tinghan; Wei, Mingtian; Wang, Yuxi; Shen, Congcong; Li, Wenting; Gou, Lantu; Yang, Jinliang] Sichuan Univ, West China Hosp, West China Med Sch, State Key Lab Biotherapy, 3-17 Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Chen, Xiangzheng; Yang, Tinghan; Wei, Mingtian; Wang, Yuxi; Shen, Congcong; Li, Wenting; Gou, Lantu; Yang, Jinliang] Sichuan Univ, West China Hosp, West China Med Sch, Canc Ctr,Collaborat Innovat Ctr Biotherapy, 3-17 Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Xu, Weiyong] Sichuan Prov Peoples Hosp, Dept Pathol, Chengdu 610072, Sichuan, Peoples R China.
   [Zhang, Hang; Zhang, Yonghui] Tsinghua Univ, Collaborat Innovat Ctr Biotherapy, Sch Med, Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China.
   [Deng, Xiangbing; Wang, Ziqiang] Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu 610072, Sichuan, Peoples R China.
   [Zeng, Yong] Sichuan Univ, West China Hosp, Dept Liver Surg, Chengdu 610064, Sichuan, Peoples R China.
   [Zeng, Yong] Sichuan Univ, West China Hosp, Liver Transplantat Ctr, Chengdu 610064, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan Provincial People's
   Hospital; Tsinghua University; Sichuan University; Sichuan University;
   Sichuan University
RP Yang, JL (corresponding author), Sichuan Univ, West China Hosp, West China Med Sch, State Key Lab Biotherapy, 3-17 Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.; Yang, JL (corresponding author), Sichuan Univ, West China Hosp, West China Med Sch, Canc Ctr,Collaborat Innovat Ctr Biotherapy, 3-17 Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.; Wang, ZQ (corresponding author), Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu 610072, Sichuan, Peoples R China.
EM jinliangyang@scu.edu.cn
RI Chen, Xiangzheng/L-8103-2015; wu, yangping/Q-9741-2017; Zeng,
   Yong/I-6290-2012
OI Chen, Xiangzheng/0000-0001-6974-4321; , Yonghui/0000-0002-9842-3049;
   Xiangbing, Deng/0000-0002-9208-7398; 
CR Agustsson T, 2007, CANCER RES, V67, P5531, DOI 10.1158/0008-5472.CAN-06-4585
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NR 31
TC 44
Z9 52
U1 1
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2190-5991
EI 2190-6009
J9 J CACHEXIA SARCOPENI
JI J. Cachexia Sarcopenia Muscle
PD MAY
PY 2016
VL 7
IS 2
BP 224
EP 232
DI 10.1002/jcsm.12054
PG 9
WC Geriatrics & Gerontology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; General & Internal Medicine
GA DP0DU
UT WOS:000378159000012
PM 27493875
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wei, LL
   Ma, BM
   Wu, D
   Wang, L
   He, XT
   Gong, Y
   Lin, CJ
AF Wei, Lili
   Ma, Baoman
   Wu, Dan
   Wang, Le
   He, Xueting
   Gong, Ying
   Lin, Chujuan
TI Mechanisms of Salidroside in Treating Premature Ovarian Insufficiency:
   Network Pharmacology and Molecular Docking
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article; Early Access
DE Salidroside; premature ovarian insufficiency; network pharmacology;
   molecular docking
AB Background Salidroside has multiple functions such as antiinflammatory, neuroprotection, immunomodulation, antioxidative stress, and antiapoptosis. However, its application in the treatment of ovarian insufficiency is not yet clear.Purpose By means of network pharmacology, we analyzed the mechanism of salidroside in premature ovarian insufficiency (POI) and verified it with molecular docking technology.Methods We collected the target of salidroside using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, screened the target genes of POI from GeneCards, and constructed protein-protein interactions (PPI) of salidroside for treating POI by Cytoscape software. We performed PPI, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of key genes using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and performed molecular docking verification of salidroside and key proteins by AutoDock software.Results From 335 salidroside and 5,177 POI target genes, 223 key genes were identified at their intersection. The top 20 targets, including insulin-like growth factor 1 (IGF1), insulin-like growth factor 2 (IGF2), and estrogen receptor 1 (ESR1), were selected based on maximal clique centrality (MCC), Degree, and maximum neighborhood component (MNC) rankings. These genes play roles in signal transduction, phosphorylation, and apoptosis regulation, and are located in the cytosol, cytoplasm, and nucleus. They are involved in protein binding and adenosine triphosphate (ATP) binding, with pathways related to cancer, phosphatidylinositol (PI), and lipid metabolism. Molecular docking revealed salidroside's strong binding to these proteins, indicating its potential in POI treatment through multi-target action.Conclusion Salidroside exerts a multi-target effect on pathways such as signal transduction, demonstrating translational potential to be developed into an effective treatment for POI patients. Its multi-target characteristics may regulate the physiological processes of POI patients, further highlighting its promise in translating research findings into clinical practice for POI therapy.
C1 [Wei, Lili] Guangxi Univ Chinese Med, Nanning, Guangxi, Peoples R China.
   [Ma, Baoman; Wu, Dan; Wang, Le; He, Xueting; Gong, Ying; Lin, Chujuan] Guangxi Univ Chinese Med, Int Zhuang Med Hosp, Dept Gynecol, Nanning 530000, Guangxi, Peoples R China.
C3 Guangxi University of Chinese Medicine; Guangxi University of Chinese
   Medicine
RP Lin, CJ (corresponding author), Guangxi Univ Chinese Med, Int Zhuang Med Hosp, Dept Gynecol, Nanning 530000, Guangxi, Peoples R China.
EM hxx160205@163.com
RI He, xueting/OKS-3757-2025
OI Lin, Chujuan/0009-0002-7571-8626
FU Guangxi Natural Science Foundation Youth Fund [2024GXNSFBA010163];
   Guangxi University of Traditional Chinese Medicine School-level
   Scientific Research Project Youth Fund [2023QN018]; Innovation Project
   of Guangxi Graduate Education of GXUCM [YCBXJ2022006]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by Guangxi Natural Science Foundation Youth
   Fund(2024GXNSFBA010163), Guangxi University of Traditional Chinese
   Medicine School-level Scientific Research Project Youth Fund (2023QN018)
   and Innovation Project of Guangxi Graduate Education of GXUCM
   (YCBXJ2022006).
CR Cao LL, 2024, HUM GENET, V143, P357, DOI 10.1007/s00439-024-02650-9
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NR 27
TC 0
Z9 0
U1 10
U2 17
PU SAGE PUBLICATIONS INDIA  PVT LTD
PI NEW DELHI
PA B-1-I-1 MOHAN CO-OPERATIVE INDUSTRIAL AREA, MATHURA RD, POST BAG NO 7,
   NEW DELHI 110 044, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD 2025 AUG 22
PY 2025
DI 10.1177/09731296251367162
EA AUG 2025
PG 12
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6JX0Y
UT WOS:001555115600001
OA hybrid
DA 2026-05-27
ER

PT J
AU Zheng, HX
   Qi, SS
   Chen, C
AF Zheng, Hongxing
   Qi, Shanshan
   Chen, Chen
TI Salidroside Improves Bone Histomorphology and Prevents Bone Loss in
   Ovariectomized Diabetic Rats by Upregulating the OPG/RANKL Ratio
SO MOLECULES
LA English
DT Article
DE salidroside; bone; osteoporosis; diabetes; OPG; RANKL; bone turnover
   markers
ID ACID-PHOSPHATASE 5B; ESTROGEN DEFICIENCY; POSTMENOPAUSAL OSTEOPOROSIS;
   OXIDATIVE STRESS; TURNOVER MARKERS; MINERAL DENSITY; BREAST-CANCER;
   MARROW FAT; WOMEN; OSTEOPROTEGERIN
AB Postmenopausal diabetic women have a high risk of fractures. Salidroside has preventive effects on estrogen deficiency-induced osteoporosis and has hypoglycemic effects on diabetes in rats. However, whether salidroside inhibits bone loss in postmenopausal diabetic patients is still unknown. Here, we established a rat model of osteoporosis to investigate the protective effects of salidroside on bone loss induced by ovariectomy combined with diabetes, also investigating the underlying mechanisms. Two-month-old female Sprague-Dawley rats were divided into three equal groups (10 rats in each group): control group (with sham operation, treated with drug vehicle); OVX/T1DM group (ovariectomized diabetic rats); OVX/T1DM-SAL group, comprising ovariectomized diabetic rats treated with salidroside (20 mg/kg body weight) by gavage. The results showed that after 60 consecutive days of treatment, the bone mineral density (BMD) of OVX/T1DM-SAL increased significantly compared with the OVX/T1DM group (p < 0.01). The level of serum bone turnover markers, including alkaline phosphatase (ALP), cross linked c-telopeptide of type I collagen (CTX-1), osteocalcin, N-terminal propeptide of type I procollagen (PINP), and tartrate-resistant acid phosphatase 5b (TRACP 5b) were all increased in the OVX/T1DM group compared with the control (p < 0.01), and those were decreased by salidroside treatment. Meanwhile, the bone histopathological changes were also attenuated, and the bone marrow adipogenesis was inhibited in salidroside treated rats. Moreover, protein and mRNA ratio of bone osteoprotegerin (OPG)/receptor activator of nuclear factor-kappa B ligand (RANKL) was upregulated in ovariectomized diabetic rats by salidroside treatment. The results above indicated that the protective effect of salidroside on bone loss induced by ovariectomy and diabetes was mainly due to its ability to suppress bone turnover, inhibit bone marrow adipogenesis, and up-regulate the OPG/RANKL ratio.
C1 [Zheng, Hongxing; Chen, Chen] Shaanxi Univ Technol, Chinese German Joint Lab Nat Prod Res, Coll Biol Sci & Engn, Hanzhong 723000, Shaanxi, Peoples R China.
   [Qi, Shanshan] Shaanxi Univ Technol, Vitamin D Res Inst, Qinling Bashan Mt Bioresources Comprehens Dept CI, Hanzhong 723000, Shaanxi, Peoples R China.
C3 Shaanxi University of Technology; Shaanxi University of Technology
RP Chen, C (corresponding author), Shaanxi Univ Technol, Chinese German Joint Lab Nat Prod Res, Coll Biol Sci & Engn, Hanzhong 723000, Shaanxi, Peoples R China.; Qi, SS (corresponding author), Shaanxi Univ Technol, Vitamin D Res Inst, Qinling Bashan Mt Bioresources Comprehens Dept CI, Hanzhong 723000, Shaanxi, Peoples R China.
EM zhenghongxing@snut.edu.cn; qishanshan@snut.edu.cn; cchen2008@yahoo.com
RI /D-7472-2011
FU High-end Foreign Experts Recruitment Programme of State Administration
   of Foreign Experts Affairs [GDT20186100426]; Shaanxi Science and
   Technology Coordinating Innovation Engineering Program [2015KTTSSF01-03,
   2015HBGC-18]; Key Project of Agricultural Science and Technology of
   Shaanxi Province [2017NY-082]; Shaanxi Province Key Research and
   Development Plan [2017SF-074]; Project of Shaanxi University of
   Technology [SLGKY2017-09]; Research Project of Shaanxi Provincial
   Education Department [17JK0153]; Postdoctoral Program in Shaanxi
   University of Technology [SLGBH16-03]; Qinling-Bashan Mountains
   Bioresources Comprehensive Development, Collaborative Innovation Center
   Research Funds [QBXT-17-9]
FX This research was funded by the High-end Foreign Experts Recruitment
   Programme of State Administration of Foreign Experts Affairs
   (GDT20186100426), Shaanxi Science and Technology Coordinating Innovation
   Engineering Program (2015KTTSSF01-03, 2015HBGC-18), the Key Project of
   Agricultural Science and Technology of Shaanxi Province (2017NY-082),
   Shaanxi Province Key Research and Development Plan (2017SF-074), Project
   of Shaanxi University of Technology (SLGKY2017-09), Research Project of
   Shaanxi Provincial Education Department (17JK0153), Postdoctoral Program
   in Shaanxi University of Technology (SLGBH16-03), and Qinling-Bashan
   Mountains Bioresources Comprehensive Development, Collaborative
   Innovation Center Research Funds (QBXT-17-9).
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NR 54
TC 48
Z9 61
U1 0
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2018
VL 23
IS 9
AR 2398
DI 10.3390/molecules23092398
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GW9YP
UT WOS:000447365100309
PM 30235836
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Dong, CY
   Wen, SH
   Zhao, SY
   Sun, S
   Zhao, SF
   Dong, W
   Han, PX
   Chen, QF
   Gong, T
   Chen, WT
   Liu, WQ
   Liu, XR
AF Dong, Chengya
   Wen, Shaohong
   Zhao, Shunying
   Sun, Si
   Zhao, Shangfeng
   Dong, Wen
   Han, Pingxin
   Chen, Qingfang
   Gong, Ting
   Chen, Wentao
   Liu, Wenqian
   Liu, Xiangrong
TI Salidroside Inhibits Reactive Astrogliosis and Glial Scar Formation in
   Late Cerebral Ischemia via the Akt/GSK-3β Pathway
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Salidroside; Astrocyte; Astrogliosis; Glial scar; Cerebral ischemia;
   Neuroprotection
ID SYNTHASE KINASE 3-BETA; CELL-CYCLE; PROVIDES NEUROPROTECTION;
   ASTROCYTES; INJURY; PROLIFERATION; POLARIZATION; PI3K/AKT; ROLES;
   REGENERATION
AB Cerebral ischemia leads to reactive astrogliosis and glial scar formation. Glial scarring can impede functional restoration during the recovery phase of stroke. Salidroside has been shown to have neuroprotective effects after ischemic stroke, but its impact on long-term neurological recovery, especially whether it regulates reactive astrogliosis and glial scar formation, is unclear. In this study, male adult C57/BL6 mice were subjected to transient cerebral ischemia injury followed by intravenous salidroside treatment. Primary astrocytes were treated with lipopolysaccharide (LPS) or conditioned medium from cultured primary neurons subjected to oxygen-glucose deprivation (CM-OGD). Salidroside significantly improved long-term functional outcomes following ischemic stroke in the rotarod and corner tests. It also reduced brain glial scar volume and decreased expression of the glial scar marker, glial fibrillary acidic protein (GFAP) and inhibited astrocyte proliferation. In primary astrocyte cultures, salidroside protected astrocytes from CM-OGD injury-induced reactive astroglial proliferation, increasing the percentage of cells in G0/G1 phase and reducing the S populations. The inhibitory effect of salidroside on the cell cycle was related to downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4) mRNA expression and increased p27Kip1 mRNA expression. Similar results were found in the LPS-stimulated injury model in astroglial cultures. Western blot analysis demonstrated that salidroside attenuated the CM-OGD-induced upregulation of phosphorylated Akt and glycogen synthase kinase 3 beta (GSK-3 beta). Taken together, these results suggested that salidroside can inhibit reactive astrocyte proliferation, ameliorate glial scar formation and improve long-term recovery, probably through its effects on the Akt/GSK-3 beta pathway.
C1 [Dong, Chengya; Wen, Shaohong; Zhao, Shunying; Dong, Wen; Chen, Qingfang; Gong, Ting; Chen, Wentao; Liu, Wenqian; Liu, Xiangrong] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing 100070, Peoples R China.
   [Sun, Si; Zhao, Shangfeng] Capital Med Univ, Beijing Tongren Hosp, Dept Neurosurg, Beijing 100176, Peoples R China.
   [Han, Pingxin; Gong, Ting] Beijing City Univ, Dept Biomed, Beijing 100094, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Liu, XR (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing 100070, Peoples R China.
EM lxrpumc@163.com
RI Zhao, Songfeng/JFJ-4645-2023; SUN, SI/MEP-2805-2025
OI Chen, Qingfang/0000-0003-0910-540X; Liu, Wenqian/0000-0003-2760-7446
FU National Natural Science Foundation of China [81871021, 81471209,
   81641055]; National Science and Technology Major Project
   [2017ZX09304018]
FX This work was supported by the National Natural Science Foundation of
   China (81871021, 81471209, 81641055) and the National Science and
   Technology Major Project (2017ZX09304018).
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NR 48
TC 26
Z9 30
U1 1
U2 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD APR
PY 2021
VL 46
IS 4
BP 755
EP 769
DI 10.1007/s11064-020-03207-8
EA JAN 2021
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA QU6VY
UT WOS:000604515400005
PM 33389472
DA 2026-05-27
ER

PT J
AU Liu, ZB
   Li, XS
   Simoneau, AR
   Jafari, M
   Zi, XL
AF Liu, Zhongbo
   Li, Xuesen
   Simoneau, Anne R.
   Jafari, Mahtab
   Zi, Xiaolin
TI Rhodiola rosea extracts and salidroside decrease the growth of bladder
   cancer cell lines via inhibition of the mTOR pathway and induction of
   autophagy
SO MOLECULAR CARCINOGENESIS
LA English
DT Article
DE Rhodiola rosea extracts; salidroside; TSC2; autophagy; translation
   initiation; p53 deficiency; bladder cancer
ID EXTENDS LIFE-SPAN; GENE-PRODUCTS; SHR-5; P53; CARCINOMA; RAPAMYCIN;
   SPECTRUM; STRESS; MICE; TUMORIGENESIS
AB The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder carcinogenesis and a potential use of anti-aging agents in bladder cancer chemoprevention. Rhodiola rosea, growing in high altitude or cold regions of the world, has been reported to have anti-aging effects in Drosophila. We demonstrated that a R. rosea extract and one of its bioactive components, salidroside, inhibited the growth of bladder cancer cell lines with a minimal effect on nonmalignant bladder epithelial cells TEU-2. Interestingly, the R. rosea extract and salidroside component exhibited a selective ability to inhibit the growth of p53 knockout primary mouse embryo fibroblasts (p53-/- MEFs) compared to their wild-type counterparts. The growth inhibitory effects of the R. rosea extract and salidroside were, however, attenuated in TSC2 and p53 double knock MEFs (TSC2-/-, p53-/- MEFs), suggesting that TSC2 protein is, at least in part, required for the growth inhibitory effects of the R. rosea extract and salidroside. The R. rosea extract and salidroside treatment of UMUC3 cells resulted in an increase of AMP-activated protein kinase (AMPK)-a phosphorylation and a decrease of 4E-BP1 phosphorylation, leading to increased binding of 4E-BP1 to m7 GTP. These results indicate that the R. rosea extract and salidroside inhibit translation initiation. Furthermore, both the R. rosea extract and salidroside treatment of UMUC3 cells caused a significant percentage of cells undergoing autophagy. Therefore, the R. rosea extract and salidroside deserve further study as novel agents for chemoprevention of bladder carcinogenesis. (c) 2011 Wiley Periodicals, Inc.
C1 [Liu, Zhongbo; Li, Xuesen; Simoneau, Anne R.; Zi, Xiaolin] Univ Calif Irvine, Dept Urol, Orange, CA 92868 USA.
   [Jafari, Mahtab; Zi, Xiaolin] Univ Calif Irvine, Dept Pharmaceut Sci, Orange, CA 92868 USA.
   [Zi, Xiaolin] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Orange, CA 92868 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Zi, XL (corresponding author), Univ Calif Irvine, Dept Urol, 101 City Dr S,Rt 81,Bldg 55,Rm 302, Orange, CA 92868 USA.
RI Liu, Zhongbo/U-3004-2017; Zi, Xiaolin/D-3924-2009
FU NIH [5R01CA122558-03, 1R21CA152804-01A1]
FX This work was supported by NIH award 5R01CA122558-03 and
   1R21CA152804-01A1 (to X. Z.). We are grateful to the Swedish Herbal
   Institute for providing us the R. rosea extract (SHR-5).
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Z9 131
U1 0
U2 49
PU WILEY-BLACKWELL
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PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0899-1987
J9 MOL CARCINOGEN
JI Mol. Carcinog.
PD MAR
PY 2012
VL 51
IS 3
BP 257
EP 267
DI 10.1002/mc.20780
PG 11
WC Biochemistry & Molecular Biology; Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Oncology
GA 875LT
UT WOS:000299032100004
PM 21520297
DA 2026-05-27
ER

PT J
AU Hu, YD
   Wu, Y
   Song, H
AF Hu, Yuandong
   Wu, Yan
   Song, Hong
TI Optimization for ultrasonic-assisted extraction of salidroside from
   Ligustrum lucidum by central composite design-response surface
   methodology
SO AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE Ultrasonic-Assisted Extraction (UAE); central composite design-response
   surface methodology; Ligustrum lucidum; reverse phase-high performance
   liquid chromatography (RP-HPLC)
ID RADICAL SCAVENGING ACTIVITY; IN-VITRO; FRUITS; CONSTITUENTS; GLUCOSIDES
AB As a new extraction method, ultrasonic-assisted extraction (UAE), whose procedure has higher extraction yield, lower extracting temperature and less power consumption, was explored to extract salidroside from Ligustrum lucidum firstly. The content of salidroside was determined by reverse phase-high performance liquid chromatography (RP-HPLC). The UAE process of salidroside from L. lucidum was optimized by using central composite design-response surface methodology (CCD-RSM). The results showed that the optimal extraction conditions were ethanol concentration of 74.14%, liquidsolid ratio of 30.31, extracting time of 68.14 min and the extraction efficiency of salidroside was 4.68 mg;g(-1). The results indicated that the UAE would be a novel method for extraction of salidroside from L. lucidum.
C1 [Hu, Yuandong] E China Normal Univ, Dept Environm Sci, Shanghai 200062, Peoples R China.
   [Hu, Yuandong; Wu, Yan; Song, Hong] NE Forestry Univ, Harbin 150040, Peoples R China.
C3 East China Normal University; Northeast Forestry University - China
RP Hu, YD (corresponding author), E China Normal Univ, Dept Environm Sci, Shanghai 200062, Peoples R China.
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NR 30
TC 2
Z9 2
U1 0
U2 28
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0816
J9 AFR J PHARM PHARMACO
JI Afr. J. Pharm. Pharmacol.
PD JUL
PY 2012
VL 6
IS 28
BP 2148
EP 2154
DI 10.5897/AJPP12.427
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 994YS
UT WOS:000307972200008
OA gold
DA 2026-05-27
ER

PT J
AU Wei, BC
   Li, H
   Han, T
   Luo, QL
   Yang, M
   Qin, QW
   Chen, YF
   Wei, SN
AF Wei, Baocan
   Li, Huang
   Han, Tao
   Luo, Qiulan
   Yang, Min
   Qin, Qiwei
   Chen, Yifang
   Wei, Shina
TI Effects of dietary salidroside on intestinal health, immune parameters
   and intestinal microbiota in largemouth bass ( Micropterus
   salmoides )
SO FISH & SHELLFISH IMMUNOLOGY
LA English
DT Article
DE Micropterus salmoides; Salidroside; Intestinal health; Immune
   parameters; Intestinal microbiota
ID DISEASE RESISTANCE; GUT HEALTH; EXPRESSION; ACTIVATION; APOPTOSIS;
   PATHWAYS; CELLS
AB The largemouth bass has become one of the economically fish in China, according to the latest China Fishery Statistical Yearbook. The farming scale is constantly increasing. Salidroside has been found in past studies to have oxidative stress reducing and immune boosting properties. In this study, the addition of six different levels of salidroside supplements were 0,40,80,120,160 and 200 mg/kg(.) A 56-day feeding trial was conducted to investigate the effects of salidroside on the intestinal health, immune parameters and intestinal microbiota composition of largemouth bass. Dietary addition of salidroside significantly affected the Keap-1 beta/Nrf-2 pathway as well as significantly increased antioxidant enzyme activities resulting in a significant increase in antioxidant capacity of largemouth bass. Dietary SLR significantly reduced feed coefficients. The genes related to tight junction proteins (Occludin, ZO-1, Claudin-4, Claudin-5) were found to be significantly upregulated in the diet supplemented with salidroside, indicating that salidroside can improve the intestinal barrier function (p < 0.05). The dietary administration of salidroside was found to significantly reduce the transcription levels of intestinal tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) (p < 0.05). Furthermore, salidroside was observed to reduce the transcription levels of intestinal apoptosis factor Bcl-2 associated death promoter (BAD) and recombinant Tumor Protein p53 (P53) (p < 0.05). Concomitantly, the beneficial bacteria, Fusobacteriota and Cetobacterium, was significantly increased in the SLR12 group, while that of pathogenic bacteria, Proteobacteria, was significantly decreased (p < 0.05). In conclusion, the medium-sized largemouth bass optimal dosage of salidroside in the diet is 120mg/kg(-1).
C1 [Wei, Baocan; Li, Huang; Yang, Min; Qin, Qiwei; Wei, Shina] South China Agr Univ, Coll Marine Sci, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China.
   [Qin, Qiwei; Wei, Shina] Nansha South China Agr Univ, Fishery Res Inst, Guangzhou 511457, Peoples R China.
   [Han, Tao; Luo, Qiulan; Chen, Yifang] GuangDong Kingkey Smart Agri Technol Co Ltd, Dongguan 523000, Peoples R China.
C3 Guangdong Laboratory for Lingnan Modern Agriculture; South China
   Agricultural University
RP Chen, YF (corresponding author), GuangDong Kingkey Smart Agri Technol Co Ltd, Dongguan 523000, Peoples R China.; Wei, SN (corresponding author), South China Agr Univ, Coll Marine Sci, Guangzhou 510642, Peoples R China.
EM 316149228@qq.com; weisn@scau.edu.cn
FU Guangzhou Rural Science and Technology Commissioner Project
   [2023E04J1243]; Special Science Found of Nansha South China Agricultural
   University Fishery Research Institute, Guangzhou [NSYYKY202304]; South
   China Agricultural University Innovation Project [S202310564052]
FX This research was funded by Guangzhou Rural Science and Technology
   Commissioner Project (2023E04J1243), Special Science Found of Nansha
   South China Agricultural University Fishery Research Institute,
   Guangzhou (NSYYKY202304), South China Agricultural University Innovation
   Project (S202310564052).
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NR 58
TC 4
Z9 4
U1 7
U2 42
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1050-4648
EI 1095-9947
J9 FISH SHELLFISH IMMUN
JI Fish Shellfish Immunol.
PD AUG
PY 2024
VL 151
AR 109750
DI 10.1016/j.fsi.2024.109750
EA JUL 2024
PG 11
WC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
GA YR8D1
UT WOS:001270291700001
PM 38969153
DA 2026-05-27
ER

PT J
AU Li, RS
   Dong, Z
   Zhuang, XY
   Liu, RC
   Yan, FY
   Chen, YF
   Gao, XF
   Shi, HM
AF Li, Ruoshui
   Dong, Zhen
   Zhuang, Xinyu
   Liu, Rongchen
   Yan, Fangying
   Chen, Yufei
   Gao, Xiufang
   Shi, Haiming
TI Salidroside prevents tumor necrosis factor-α-induced vascular
   inflammation by blocking mitogen-activated protein kinase and NF-κB
   signaling activation
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; endothelial cells; vascular inflammation; monocyte
   adhesion; tumor necrosis factor-alpha
ID CELL-ADHESION MOLECULE-1; TNF-ALPHA; ENDOTHELIAL-CELLS; TRANSCRIPTIONAL
   REGULATION; VCAM-1 EXPRESSION; IN-VITRO; ATHEROSCLEROSIS; ICAM-1;
   INVOLVEMENT; DISEASE
AB Vascular inflammation is a key factor in the pathogenesis of atherosclerosis. Salidroside is an important active ingredient extracted from the root of the Rhodiola rosea plant, which has been reported to have antioxidative, anti-cancer, neuroprotective and cardioprotective effects. However, the effects of salidroside on vascular inflammation have not been clarified. The purpose of the present study was to investigate the protective effects of salidroside against tumor necrosis factor (TNF)-alpha-induced vascular inflammation in cardiac microvascular endothelial cells (CMECs), a specific cell type derived from coronary micro-vessels. Over a 24-h period, salidroside did not exert any significant cytotoxicity up to a dose of 100 mu M. Additionally, salidroside decreased the expression levels of the cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) in TNF-alpha-stimulated CMECs, thus suppressing monocyte-to-CMEC adhesion. Salidroside also decreased the production of inflammatory cytokines such as interleukin (IL)-1 beta, IL-6 and monocyte chemotactic protein 1 (MCP-1) in TNF-alpha-induced CMECs, as well as suppressing TNF-alpha-activated mitogen-activated protein kinase (MAPK) and NF-kappa B activation. Since MAPKs and NF-kappa B both serve notable roles in regulating the expression of VCAM-1, IL-1 beta, IL-6 and MCP-1, the present study provided a preliminary understanding of the mechanism underlying the protective effects of salidroside. Overall, salidroside alleviated vascular inflammation by mediating MAPK and NF-kappa B activation in TNF-alpha-induced CMECs. These results indicated that salidroside may have potential applications as a therapeutic agent against vascular inflammation and atherosclerosis.
C1 [Li, Ruoshui; Zhuang, Xinyu; Liu, Rongchen; Yan, Fangying; Chen, Yufei; Gao, Xiufang; Shi, Haiming] Fudan Univ, Huashan Hosp, Dept Cardiol, 12 South Wulumuqi Rd, Shanghai 200036, Peoples R China.
   [Dong, Zhen] Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University
RP Gao, XF; Shi, HM (corresponding author), Fudan Univ, Huashan Hosp, Dept Cardiol, 12 South Wulumuqi Rd, Shanghai 200036, Peoples R China.
EM gaoxiufang_hs@163.com; shihaiming_hs@163.com
RI ; Zhuang, Xinyu/KQU-2437-2024
OI Li, Ruoshui/0000-0003-3922-686X; 
FU National Natural Science Foundation of China [81573710, 81573711]
FX The present study was supported by the National Natural Science
   Foundation of China (grant nos. 81573710 and 81573711).
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U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV
PY 2019
VL 18
IS 5
BP 4137
EP 4143
DI 10.3892/etm.2019.8064
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA JW7GX
UT WOS:000503217400107
PM 31656544
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gemma, S
   Multari, G
   Turco, L
   Gallo, FR
AF Gemma, Simonetta
   Multari, Giuseppina
   Turco, Laura
   Gallo, Francesca Romana
TI A densitometric HPTLC method for the simultaneous quali-quantitative
   determination of rosavin and salidroside in Rhodiola rosea L.
   based commercial products: A quick screening by HPTLC-based fingerprint
   and antioxidant evaluation
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE Antioxidant activity; HPTLC-densitometry; rosavin; salidroside;
   spectrophotometry evaluation
ID AUTHENTICITY
AB A simple and reproducible High-Performance Thin-Layer Chromatography (HPTLC) densitometric method was developed for the simultaneous quali-quantitative determination of rosavin and salidroside in commercial products based on Rhodiola rosea L. Their content was compared with Vitango (R), one of the first Traditional Herbal Medicine released on the market. Fingerprints of commercial product extracts and their rosavin and salidroside quantifications were performed, on the same layer, by densitometric evaluation in absorption mode (272 nm). Their antioxidant activity was also evaluated in fluorescence mode (517 nm). The Retention Factors (Rf) were 0.39 +/- 0.02 for rosavin and 0.58 +/- 0.02 for salidroside. Linear regression analysis data in the concentration range of 1.0-5.0 mu g/spot showed a strong linearity relationship with R2 = 0.9888 for rosavin and R2 = 0.9982 for salidroside. The amount of rosavin and salidroside in formulations ranged from 0.7 to 6.0% and 0.9 to 10.7% respectively. Simultaneous HPTLC rosavin and salidroside quantification and their antioxidant evaluation, can be considered quick, cost-effective and green method, for plant extracts/formulations analysis.
C1 [Gemma, Simonetta; Multari, Giuseppina; Gallo, Francesca Romana] Ist Super Sanita, Natl Ctr Drug Res & Evaluat, I-00161 Rome, Italy.
   [Turco, Laura] Ist Super Sanita, Environm & Hlth Dept, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Istituto Superiore di Sanita (ISS)
RP Gemma, S (corresponding author), Ist Super Sanita, Natl Ctr Drug Res & Evaluat, I-00161 Rome, Italy.
EM simonetta.gemma@iss.it
RI Multari, Giuseppina/G-3522-2018; Gemma, Simonetta/IVH-5868-2023; Gallo,
   Francesca Romana/M-9770-2017
OI Gemma, Simonetta/0000-0001-5502-9271; Gallo, Francesca
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U1 3
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PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1082-6076
EI 1520-572X
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PD SEP 14
PY 2025
VL 48
IS 11-15
BP 282
EP 293
DI 10.1080/10826076.2025.2462263
EA FEB 2025
PG 12
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6FV4X
UT WOS:001430949000001
OA hybrid
DA 2026-05-27
ER

PT J
AU Wang, J
   Xiao, L
   Zhu, LP
   Hu, M
   Wang, QJ
   Yan, TH
AF Wang, Jing
   Xiao, Lu
   Zhu, Lingpeng
   Hu, Mei
   Wang, Qiujuan
   Yan, Tianhua
TI The Effect of Synthetic Salidroside on Cytokines and Airway Inflammation
   of Asthma Induced by Diisocyanate (TDI) in Mice by Regulating
   GATA3/T-bet
SO INFLAMMATION
LA English
DT Article
DE salidroside; diisocyanate (TDI); asthma model; cytokines
ID TOLUENE DIISOCYANATE; OCCUPATIONAL ASTHMA; ALLERGIC-ASTHMA; MURINE
   MODEL; MOUSE MODEL; HYPERRESPONSIVENESS; EXPOSURE
AB This study was conducted to explore the anti-asthma effects of synthetic salidroside on cytokines and airway inflammation of asthma induced by diisocyanate (TDI) in mice. The experiment was carried out 60 female BALB/C mice which were randomly assigned to six experimental groups: control, vehicle, model, dexamethasone (2 mg/kg), and salidroside (24 and 48 mg/kg). After the experiment, histological studies were evaluated by the hematoxylin and eosin staining, the bronchoalveolar lavage fluid (BALF) and blood were collected from the animals, and the composition of the induced inflammatory cells, and the concentrations of certain cytokines (IL-4, INF-gamma) were evaluated. GATA3 and T-bet mRNAs were evaluated by QPCR. Our study demonstrated that salidroside inhibited TDI-induced increases in eosinophil count; IL-4 and INF-gamma were recovered. Histological studies demonstrated that salidroside substantially inhibited TDI-induced eosinophilia in lung tissue. Salidroside can improve T-bet mRNA and reduce GATA3 mRNA in lung. These findings suggest that salidroside may effectively ameliorate the progression of asthma and could be used as a therapy for patients with allergic asthma by regulating GATA3/T-bet balance.
C1 [Wang, Jing; Xiao, Lu; Zhu, Lingpeng; Hu, Mei; Wang, Qiujuan; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing, Jiangsu, Peoples R China.
EM machunhuabest@126.com
RI Su, Tianyuan/Y-7054-2019
FU National twelve five major drug discovery project [2011ZX09102-002-01]
FX This work was supported by National twelve five major drug discovery
   project (2011ZX09102-002-01).
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NR 16
TC 22
Z9 29
U1 0
U2 19
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD APR
PY 2015
VL 38
IS 2
BP 697
EP 704
DI 10.1007/s10753-014-9979-x
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CC7NC
UT WOS:000350553800027
PM 25052478
DA 2026-05-27
ER

PT J
AU Zhao, DM
   Sun, XY
   Lv, SJ
   Sun, MY
   Guo, HT
   Zhai, YJ
   Wang, Z
   Dai, P
   Zheng, L
   Ye, MZ
   Wang, XP
AF Zhao, Dongming
   Sun, Xinyi
   Lv, Shujie
   Sun, Miying
   Guo, Huatao
   Zhai, Yujia
   Wang, Zhi
   Dai, Peng
   Zheng, Lina
   Ye, Mingzhe
   Wang, Xinpeng
TI Salidroside attenuates oxidized low-density lipoprotein-induced
   endothelial cell injury via promotion of the AMPK/SIRT1 pathway
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE salidroside; atherosclerosis; adenosine monophosphate-activated protein
   kinase; sirtuin 1 pathway; oxidative stress; mitochondrial dysfunction
ID ACTIVATED PROTEIN-KINASE; PEROXIDE-INDUCED INJURY; OXIDATIVE STRESS;
   MITOCHONDRIAL DYSFUNCTION; SIRT1; AMPK; APOPTOSIS; ATHEROSCLEROSIS;
   SUPPRESSION; SENESCENCE
AB Oxidized low-density lipoprotein (ox-LDL)-induced endothelial damage contributes to the initiation and pathogenesis of atherosclerosis. Salidroside can alleviate atherosclerosis and attenuate endothelial cell injury induced by ox-LDL. However, the mechanisms involved in this process are not fully understood. Therefore, the purpose of the present study was to investigate the role of the adenosine monophosphate-activated protein kinase (AMPK)/sirtuin (SIRT)1 pathway in the protection of salidroside against ox-LDL-induced human umbilical vein endothelial cells (HUVECs) injuries. The results revealed that salidroside reverses ox-LDL-induced HUVECs injury as demonstrated by the upregulation of cell viability and downregulation of LDH release. In addition, salidroside increased the expression of the SIRT1 protein in ox-LDL-treated HUVECs. Next, it was demonstrated that SIRT1 knockdown induced by transfection with small interfering (si)RNA targeting SIRT1 (siSRT1) abolished the protection of salidroside against ox-LDL-induced HUVECs injuries. This was illustrated by a decrease in cell viability and an increase in LDH release, caspase-3 activity and apoptosis rate. Furthermore, salidroside mitigated ox-LDL-induced reactive oxygen species production, upregulated malondialdehyde content and NADPH oxidase 2 expression and decreased superoxide dismutase and glutathione peroxidase activities, while these effects were also reversed by siSIRT1 transfection. In addition, it was demonstrated that salidroside suppressed ox-LDL-induced mitochondrial dysfunction as demonstrated by the increase in mitochondrial membrane potential and decreases in cytochrome c expression, and Bax/Bcl-2 reductions. However, these effects were eliminated by SIRT1 knockdown. Finally, it was demonstrated that salidroside significantly upregulated the phosphorylated-AMPK expression in ox-LDL-treated HUVECs and AMPK knockdown induced by transfection with AMPK siRNA (siAMPK) leads to elimination of the salidroside-induced increase in cell viability and the decrease in LDH release. Notably, siAMPK transfection further decreased the expression of SIRT1. In conclusion, these results suggested that salidroside protects HUVECs against ox-LDL injury through inhibiting oxidative stress and improving mitochondrial dysfunction, which were dependent on activating the AMPK/SIRT1 pathway.
C1 [Zhao, Dongming; Lv, Shujie; Sun, Miying; Guo, Huatao; Zhai, Yujia; Wang, Zhi; Dai, Peng; Zheng, Lina; Ye, Mingzhe; Wang, Xinpeng] Beihua Univ, Affiliated Hosp, Dept Cardiovasc, Jilin 132011, Jilin, Peoples R China.
   [Sun, Xinyi] Beihua Univ, Affiliated Hosp, Dept Endocrinol & Metab, 12 Jiefang Middle Rd, Jilin 132011, Jilin, Peoples R China.
C3 Beihua University; Beihua University
RP Sun, XY (corresponding author), Beihua Univ, Affiliated Hosp, Dept Endocrinol & Metab, 12 Jiefang Middle Rd, Jilin 132011, Jilin, Peoples R China.
EM sunxiny0103@qq.com
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NR 61
TC 56
Z9 60
U1 1
U2 21
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD JUN
PY 2019
VL 43
IS 6
BP 2279
EP 2290
DI 10.3892/ijmm.2019.4153
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HX8IP
UT WOS:000467649900002
PM 30942428
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Chen, SF
   Tsai, HJ
   Hung, TH
   Chen, CC
   Lee, CY
   Wu, CH
   Wang, PY
   Liao, NC
AF Chen, Szu-Fu
   Tsai, Hsin-Ju
   Hung, Tai-Ho
   Chen, Chien-Cheng
   Lee, Chao Yu
   Wu, Chun-Hu
   Wang, Pei-Yi
   Liao, Nien-Chieh
TI Salidroside Improves Behavioral and Histological Outcomes and Reduces
   Apoptosis via PI3K/Akt Signaling after Experimental Traumatic Brain
   Injury
SO PLOS ONE
LA English
DT Article
ID CONTROLLED CORTICAL IMPACT; PROGRAMMED CELL-DEATH; CEREBRAL-ISCHEMIA;
   TEMPORAL PROFILE; WHITE-MATTER; KINASE-B; SURVIVAL; BCL-2; ACTIVATION;
   INCREASES
AB Background: Traumatic brain injury (TBI) induces a complex sequence of apopototic cascades that contribute to secondary tissue damage. The aim of this study was to investigate the effects of salidroside, a phenolic glycoside with potent anti-poptotic properties, on behavioral and histological outcomes, brain edema, and apoptosis following experimental TBI and the possible involvement of the phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling pathway.
   Methodology/Principal Findings: Mice subjected to controlled cortical impact injury received intraperitoneal salidroside (20, or 50 mg/kg) or vehicle injection 10 min after injury. Behavioral studies, histology analysis and brain water content assessment were performed. Levels of PI3K/Akt signaling-related molecules, apoptosis-related proteins, cytochrome C (CytoC), and Smac/DIABLO were also analyzed. LY294002, a PI3K inhibitor, was administered to examine the mechanism of protection. The protective effect of salidroside was also investigated in primary cultured neurons subjected to stretch injury. Treatment with 20 mg/kg salidroside_ignificantly improved functional recovery and reduced brain tissue damage up to post-injury day 28. Salidroside_lso significantly reduced neuronal death, apoptosis, and brain edema at day 1. These changes were associated with significant decreases in cleaved caspase-3, CytoC, and Smac/DIABLO at days 1 and 3. Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3. This beneficial effect was abolished by pre-injection of LY294002. Moreover, delayed administration of salidroside at 3 or 6 h post-injury reduced neuronal damage at day 1. Salidroside treatment also decreased neuronal vulnerability to stretch-induced injury in vitro.
   Conclusions/Significance: Post-injury salidroside improved long-term behavioral and histological outcomes and reduced brain edema and apoptosis following TBI, at least partially via the PI3K/Akt signaling pathway.
C1 [Chen, Szu-Fu; Tsai, Hsin-Ju; Wu, Chun-Hu; Wang, Pei-Yi] Natl Def Med Ctr, Dept Physiol, Taipei, Taiwan.
   [Chen, Szu-Fu; Tsai, Hsin-Ju; Wu, Chun-Hu; Wang, Pei-Yi] Natl Def Med Ctr, Dept Biophys, Taipei, Taiwan.
   [Chen, Szu-Fu; Tsai, Hsin-Ju; Chen, Chien-Cheng; Wu, Chun-Hu] Cheng Hsin Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Hung, Tai-Ho] Chang Gung Mem Hosp, Dept Obstet & Gynecol, Taipei 10591, Taiwan.
   [Hung, Tai-Ho] Chang Gung Univ, Coll Med, Taipei, Taiwan.
   [Lee, Chao Yu] Kings Coll London, Dept Neurosci, Inst Psychiat, London WC2R 2LS, England.
   [Liao, Nien-Chieh] Cheng Hsin Gen Hosp, Dept Clin Pathol, Taipei, Taiwan.
C3 National Defense Medical University; National Defense Medical
   University; Cheng Hsin General Hospital; Chang Gung Memorial Hospital;
   Chang Gung University; University of London; King's College London;
   Cheng Hsin General Hospital
RP Chen, SF (corresponding author), Natl Def Med Ctr, Dept Physiol, Taipei, Taiwan.
EM szufuchen@yahoo.com.tw
RI WU, CHUN-HU/P-3958-2018; /K-5040-2012; Chen, Chien Cheng/V-6564-2018;
   Hung, Tai-Ho/ABD-1800-2020
OI WU, CHUN-HU/0000-0001-6851-7936; 
FU National Science Council of Taiwan, R.O.C. [98-2314-B-350-001-MY3];
   Cheng Hsin General Hospital
FX This work was supported by the National Science Council of Taiwan,
   R.O.C. (98-2314-B-350-001-MY3 to S.-F.C.) and the Cheng Hsin General
   Hospital (S.-F.C.). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 61
TC 33
Z9 45
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 24
PY 2012
VL 7
IS 9
AR e45763
DI 10.1371/journal.pone.0045763
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 016YB
UT WOS:000309554700067
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU You, BY
   Dun, YS
   Zhang, WL
   Jiang, LJ
   Li, H
   Xie, MR
   Liu, Y
   Liu, SX
AF You, Baiyang
   Dun, Yaoshan
   Zhang, Wenliang
   Jiang, Lingjun
   Li, Hui
   Xie, Murong
   Liu, Yuan
   Liu, Suixin
TI Anti-insulin resistance effects of salidroside through mitochondrial
   quality control
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE insulin resistance; mitochondrion; reactive oxygen species; salidroside;
   AMPK/SIRT1
ID INDUCED OXIDATIVE STRESS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   PROTEIN-KINASE; DYSFUNCTION; ACTIVATION; MITOPHAGY; AMPK; DYNAMICS;
   MODEL
AB Mitochondrial quality control (MQC) and function are determinants for cellular energy metabolism, and their disorders are reported to play an important role in the development of insulin resistance (IR). Salidroside was reported to have beneficial effects on MQC through AMPK pathway; however, it is unknown whet her salidroside exerts anti-IR effect with this action. This study sought to investigate the effects of salidroside on IR with an exploration of the mechanisms of its action. Experimental IR models were adopted in high-fat-diet (HFD)-fed mice and palmitate-treated C2C12 myotubes, respectively. Blood levels of glucose and insulin as well as cellular glucose uptake were determined, and mitochondrial function and MQC-associated parameters and reactive oxygen species (ROS) production were analyzed based on treatments with the activator (AICAR), inhibitors (compound C and EX-527) or specific siRNA of Ampk/Sirt1 and mitochondrial ROS scavenger (mito-TEMPO). Protein expression level was determined by Western blot, cellular observation by transmission electron microscope and ROS production by functional analysis kits. Salidroside reduced IR and activated insulin signaling along with the stimulation of AMPK/SIRT1 signaling and downstream regulation of MQC and ROS production. These salidroside effects were comparable to those of AICAR and could be prevented by AMPK/SIRT1 inhibitors or siRNAs, respectively. Salidroside reduces IR and regulates MQC and ROS production by activating AMPK/SIRT1 signaling pathway. Since IR is a critical issue for public health, to explore a potent agent against IR is of high interest. The anti-IR effects of salidroside warrant further experimental and clinical studies.
C1 [You, Baiyang; Dun, Yaoshan; Zhang, Wenliang; Jiang, Lingjun; Li, Hui; Xie, Murong; Liu, Yuan; Liu, Suixin] Cent South Univ, Xiangya Hosp, Dept Rehabil, Cardiac Rehabil Ctrr, Changsha, Hunan, Peoples R China.
C3 Central South University
RP Liu, SX (corresponding author), Cent South Univ, Xiangya Hosp, Dept Rehabil, Cardiac Rehabil Ctrr, Changsha, Hunan, Peoples R China.
EM liusuixin@csu.edu.cn
RI Dun, Yaoshan/GOH-2956-2022; Liu, Suixin/GOH-2956-2022
OI Dun, Yaoshan/0000-0001-8642-9024; Liu, Suixin/0000-0001-7621-0096; Liu,
   Suixin/0000-0001-7621-0096
FU National Nature Science Foundation of China [81672262, 81702241];
   National Development and Reform Commission Foundation of China
   [[2012]1521]
FX This work was supported by grants from the National Nature Science
   Foundation of China (Grant number 81672262 to L S X and 81702241 to L Y)
   and the National Development and Reform Commission Foundation of China
   (No. [2012]1521 to L S X).
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NR 47
TC 21
Z9 23
U1 0
U2 38
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD FEB
PY 2020
VL 244
IS 2
BP 383
EP 393
DI 10.1530/JOE-19-0393
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KD5NB
UT WOS:000507911600011
PM 31794423
OA Bronze
DA 2026-05-27
ER

PT J
AU Liang, L
   Ma, Z
   Dong, M
   Ma, J
   Jiang, A
   Sun, X
AF Liang, L.
   Ma, Z.
   Dong, M.
   Ma, J.
   Jiang, A.
   Sun, X.
TI Protective effects of salidroside against isoflurane-induced cognitive
   impairment in rats
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Cognitive dysfunction; isoflurane; inflammatory; oxidative stress;
   salidroside
ID NITRIC-OXIDE SYNTHASE; KAPPA-B PATHWAY; OXIDATIVE STRESS; AGED RATS;
   DYSFUNCTION; DEFICITS; ANESTHESIA; MICE; NEUROINFLAMMATION; INVOLVEMENT
AB Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protective role and possible mechanisms of salidroside against isoflurane-induced cognitive impairment. Sprague Dawley rats were randomly assigned to five groups and were treated with or without salidroside before isoflurane exposure. Open-field and fear conditioning tests were conducted to evaluate the cognitive function of the rats. Moreover, the hippocampus tissues were obtained for biochemical analysis. The results showed that the isoflurane anesthesia decreased the freezing time to context significantly at 48 h after the isoflurane exposure in the fear conditioning test. Salidroside could ameliorate isoflurane-induced cognitive dysfunction. Further analysis demonstrated salidroside markedly suppressed the release of tumor necrosis factor- and interleukin-1. Moreover, salidroside reversed the decreased activity of choline acetyltransferase, superoxide dismutase, glutathione peroxidase, and content of acetylcholine, as well as the increased activity of acetylcholine esterase and content of malondialdehyde in hippocampal tissue of isoflurane-exposed rats. According to the results, we concluded that that salidroside has a protective effect against isoflurane-induced cognitive dysfunction by inhibiting excessive inflammatory responses, decreasing oxidative stress, and regulating the cholinergic system.
C1 [Liang, L.; Ma, Z.; Ma, J.; Jiang, A.] Qingdao Univ, Dept Anesthesiol, Affiliated Yantai Yuhuangding Hosp, Yantai, Shandong, Peoples R China.
   [Dong, M.] Qingdao Univ, Cent Sterile Supply Dept, Affiliated Yantai Yuhuangding Hosp, Yantai, Shandong, Peoples R China.
   [Sun, X.] Binzhou Med Univ, Yantai Affiliated Hosp, Yantai 264100, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University; Shandong Medical &
   Pharmaceutical University
RP Sun, X (corresponding author), Binzhou Med Univ, Yantai Affiliated Hosp, Yantai 264100, Shandong, Peoples R China.
EM xuehuasun2016@126.com
RI Ma, Jiahai/AAV-9133-2021
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NR 24
TC 24
Z9 27
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD DEC
PY 2017
VL 36
IS 12
BP 1295
EP 1302
DI 10.1177/0960327116688068
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA FM4NC
UT WOS:000414993600007
PM 28084090
DA 2026-05-27
ER

PT J
AU Yan, GH
   Choi, YH
AF Yan, Guang Hai
   Choi, Yun Ho
TI Salidroside Attenuates Allergic Airway Inflammation Through Negative
   Regulation of Nuclear Factor-Kappa B and p38 Mitogen-Activated Protein
   Kinase
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE salidroside; asthma; airway inflammation; nuclear factor-kappa B
   (NF-kappa B); p38
ID EPITHELIAL-CELLS; NITRIC-OXIDE; ASTHMA; DISEASE; MECHANISMS; MICE;
   LIPOPOLYSACCHARIDE; OLIGONUCLEOTIDE; AMIDE; LUNG
AB Salidroside is a biologically active ingredient of Rhodiola rosea, which has several interesting biological properties, including anti-oxidant and anti-inflammatory; however, its anti-allergic effects are poorly understood. The objective of this study is to determine whether salidroside attenuates the inflammatory response in an ovalbumin (OVA)-induced asthma model. OVA-sensitized/challenged mice show airway hyperresponsiveness (AHR) to inhaled methacholine and have an increased amount of T-helper2 type cytokines [interleukin (IL)-4, IL-5, and IL-13] and eosinophils in their bronchoalveolar lavage fluids and lung tissues. However, three successive intraperitoneal administrations of salidroside before the last OVA challenge result in significant inhibition of these asthmatic reactions. Moreover, OVA significantly increases the activation of nuclear factor-kappa B (NF-kappa B) and p38 mitogen activated protein kinase (MAPK) in lung tissues, whereas salidroside markedly suppresses NF-kappa B translocation and reduces phosphorylation of p38 MAPK. Furthermore, salidroside attenuates the expression of intercellular adhesion molecule 1 and IL-6 through modulating the activities of p38 MAPK and NF-kappa B in the BEAS-2B cells stimulated by proinflammatory cytokines. These findings indicate that salidroside protects against OVA-induced airway inflammation and AHR, at least in part via downregulation of NF-kappa B and p38 MAPK activities. Our data support the utility of salidroside as a potential medicine for the treatment of asthma.
C1 [Yan, Guang Hai] Yanbian Univ, Sch Basic Med Sci, Dept Anat & Histol & Embryol, Yanji 133002, Jilin, Peoples R China.
   [Choi, Yun Ho] Chonbuk Natl Univ, Dept Anat, Sch Med, Inst Med Sci, Jeonju 561180, Jeonbuk, South Korea.
C3 Yanbian University; Jeonbuk National University
RP Choi, YH (corresponding author), Chonbuk Natl Univ, Dept Anat, Sch Med, Inst Med Sci, Jeonju 561180, Jeonbuk, South Korea.
EM why76@jbnu.ac.kr
OI Yan, Guanghai/0000-0001-8058-7822
FU National Natural Science Foundation of China [81060003, 81260665];
   Project of Research & Innovation of Jilin Youth Leader and Team
   [20140519013JH]; Education Department of Jilin Province in China
   [2013.2]; Chonbuk National University Medical School Fund
FX This work was supported by the National Natural Science Foundation of
   China (81060003, 81260665), the Project of Research & Innovation of
   Jilin Youth Leader and Team (20140519013JH), the Project of Education
   Department of Jilin Province in China (2013.2), and a grant [2014] from
   Chonbuk National University Medical School Fund.
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NR 27
TC 28
Z9 34
U1 0
U2 14
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD OCT
PY 2014
VL 126
IS 2
BP 126
EP 135
DI 10.1254/jphs.14037FP
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AS1KD
UT WOS:000344039200005
PM 25341565
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU You, BY
   Zhang, J
   Yang, CY
   Dun, Y
   Qi, DK
   Long, YQ
   Cheng, J
   Lin, Y
   Zhou, NJ
   Zeng, TH
   Dong, J
   Liu, SX
AF You, Baiyang
   Zhang, Jie
   Yang, Chuyan
   Dun, Yaoshan
   Qi, Dake
   Long, Yuqiong
   Cheng, Jing
   Lin, Yuan
   Zhou, Nanjiang
   Zeng, Tanghao
   Dong, Jie
   Liu, Suixin
TI Salidroside protects against myocardial infarction via activating
   MIF-mediated mitochondrial quality control
SO CHINESE MEDICINE
LA English
DT Article
DE Salidroside; Macrophage migration inhibitory factor; Myocardial
   infarction; Cardiomyocyte apoptosis; Mitochondrial quality control
ID CARDIAC-HYPERTROPHY; APOPTOSIS; INJURY; EXPRESSION
AB BackgroundSalidroside is a potential therapeutic agent for myocardial infarction (MI), exerting therapeutic effects on macrophage migration inhibitory factor (MIF)-regulated mitochondrial quality control. Our aim was to explore the mechanism through which the MIF pathway regulates salidroside-mediated resistance to hypoxia-induced cardiomyocyte apoptosis.MethodsLigation surgery of the left anterior descending branch of the coronary artery was employed to establish a myocardial infarction mouse model. Salidroside at low and high doses was administered to the mice for 4 weeks after the surgery. Cardiac function was evaluated via echocardiography. Morphological changes, apoptosis, and mitochondrial damage in the myocardium were examined. For the cell experiments, cardiomyocytes were treated with salidroside under oxygen-glucose deprivation (OGD) conditions and were either treated with recombinant MIF (rMIF) or transfected with Mif-siRNA. Subsequently, mitochondrial quality control and apoptosis were assessed.ResultsSalidroside enhanced mitochondrial quality control in MI model mice, mitigated apoptosis and improved cardiac dysfunction. Transmission electron microscopy indicated that there were fewer damaged mitochondria in the salidroside-treated mice compared with the control mice. MIF and downstream mitochondrial quality control pathways were activated in the mice treated with salidroside. Consistently, the cell experiments demonstrated that salidroside and rMIF alleviated apoptosis, improved impaired mitochondrial quality control in OGD-induced cells and activated MIF signaling in OGD-induced cells. However, these effects of salidroside were partially blocked by Mif-siRNA transfection.ConclusionSalidroside alleviated myocardial apoptosis and ameliorated cardiac dysfunction in MI model mice through the MIF pathway and downstream mitochondrial quality control.
C1 [You, Baiyang; Zhang, Jie; Dun, Yaoshan; Long, Yuqiong; Lin, Yuan; Zhou, Nanjiang; Zeng, Tanghao; Dong, Jie; Liu, Suixin] Cent South Univ, Xiangya Hosp, Div Cardiac Rehabil, Dept Phys Med & Rehabil, Changsha, Hunan, Peoples R China.
   [You, Baiyang; Dun, Yaoshan; Liu, Suixin] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.
   [You, Baiyang; Yang, Chuyan; Dun, Yaoshan; Lin, Yuan; Dong, Jie; Liu, Suixin] Cent South Univ, Natl Reg Ctr Neurol Dis, Xiangya Hosp, Dept Phys Med & Rehabil, Jiangxi, Peoples R China.
   [Yang, Chuyan] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Clin Coll, Dept Neurol,Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.
   [Qi, Dake] Univ Manitoba, Coll Pharm, Winnipeg, MB, Canada.
   [Cheng, Jing] Shenzhen Dist Yantian Peoples Hosp, Dept Cardiovasc, Shenzhen, Guangdong, Peoples R China.
C3 Central South University; Central South University; Nanchang Medical
   College; University of Manitoba
RP Dong, J; Liu, SX (corresponding author), Cent South Univ, Xiangya Hosp, Div Cardiac Rehabil, Dept Phys Med & Rehabil, Changsha, Hunan, Peoples R China.; Liu, SX (corresponding author), Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.; Dong, J; Liu, SX (corresponding author), Cent South Univ, Natl Reg Ctr Neurol Dis, Xiangya Hosp, Dept Phys Med & Rehabil, Jiangxi, Peoples R China.
EM 3321293753@qq.com; liusuixin@csu.edu.cn
RI Dun, Yaoshan/GOH-2956-2022
FU National Natural Science Foundation of China
FX We express our sincere gratitude to Jeffrey W. Ripley-Gonzalez, a member
   of our research team, for his invaluable assistance in refining the
   language of this manuscript.
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NR 56
TC 3
Z9 3
U1 1
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD FEB 28
PY 2025
VL 20
IS 1
AR 27
DI 10.1186/s13020-025-01076-3
PG 15
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA Y8G2N
UT WOS:001434431100001
PM 40016840
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, MC
   Shi, HM
   Gao, XF
   Wang, H
AF Xu, Mao-Chun
   Shi, Hai-Ming
   Gao, Xiu-Fang
   Wang, Hao
TI Salidroside attenuates myocardial ischemiareperfusion injury via
   PI3K/Akt signaling pathway
SO JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
LA English
DT Article
DE myocardial ischemiareperfusion; salidroside; signal transduction;
   apoptosis
ID ISCHEMIA-REPERFUSION INJURY; AKT; APOPTOSIS; CARDIOMYOCYTES; CASPASE-3;
   PROTECTS; SURVIVAL; BCL-2
AB To investigate the cardioprotective effects of salidroside on myocardial ischemiareperfusion injury (IRI) in rabbits and the underlying action mechanisms in PI3K/Akt signaling pathway, a rabbit ischemia/reperfusion model was created by ligating the left anterior descending coronary arterial branch for 30min and by releasing the ligature to allow reperfusion for 120min. Salidroside or salidroside+PI3K inhibitor (LY294002) was administered via intracoronary injections at the onset of reperfusion. Apoptosis of cardiomyocytes was assessed by terminal dUTP nick-end labeling assay, and the expression of apoptosis-related proteins was observed by immunohistochemistry. The expressions of total Akt and phosphorylated Akt (p-Akt) were detected by western blot analysis. The results showed that intracoronary injection of salidroside at the onset of reperfusion markedly reduced the apoptosis of cardiomyocytes, significantly increasing Bcl-2 and p-Akt proteins expressions and decreasing Bax and caspase-3 expressions in the hearts subjected to ischemia followed by 120-min reperfusion. However, the anti-apoptotic effect induced by salidroside was inhibited by LY294002, which blocked the activation of Akt. These results suggested that intracoronary administration of salidroside at the onset of reperfusion could significantly reduce the IRI-induced apoptosis of cardiomyocytes, and this protective mechanism seemed to be mediated by the PI3KAkt signaling pathway.
C1 [Xu, Mao-Chun; Shi, Hai-Ming; Gao, Xiu-Fang] Fudan Univ, Huashan Hosp, Dept Cardiol, Shanghai 200040, Peoples R China.
   [Wang, Hao] Fudan Univ, Key Lab Mol Med, Minist Educ, Shanghai Med Sch, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University
RP Shi, HM (corresponding author), Fudan Univ, Huashan Hosp, Dept Cardiol, Shanghai 200040, Peoples R China.
EM shihm@medmail.com.cn
FU Natural Science Foundation of China [81001561]
FX This study was financially supported by the funding of the Natural
   Science Foundation of China (No. 81001561).
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NR 23
TC 38
Z9 44
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-6020
EI 1477-2213
J9 J ASIAN NAT PROD RES
JI J. Asian Nat. Prod. Res.
PD MAR 1
PY 2013
VL 15
IS 3
BP 244
EP 252
DI 10.1080/10286020.2012.762358
PG 9
WC Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Pharmacology & Pharmacy
GA 142EV
UT WOS:000318780300005
PM 23418859
DA 2026-05-27
ER

PT J
AU Yang, ZL
   Huang, X
   Lai, WF
   Tang, YH
   Liu, JJ
   Wang, YZ
   Chu, KD
   Brown, J
   Hong, GZ
AF Yang, Zelin
   Huang, Xin
   Lai, Wenfang
   Tang, Yuheng
   Liu, Junjie
   Wang, Yingzheng
   Chu, Kedan
   Brown, John
   Hong, Guizhu
TI Synthesis and identification of a novel derivative of salidroside as a
   selective, competitive inhibitor of monoamine oxidase B with enhanced
   neuroprotective properties
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Lipophilicity; Monoamine oxidase B; Neuroprotection; Reverse virtual
   docking; Salidroside derivatives
ID BRAIN; ISCHEMIA
AB Salidroside [(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahy-dro-2H-pyran-3,4,5-triol] is an antioxidant, anti-inflammatory and neuroprotective agent, but its drug-like properties are unoptimized and its mechanism of actions is uncertain. We synthesized twenty-six novel derivatives of salidroside and examined them in CoCl2-treated PC12 cells using MTT assay. pOBz, synthesized by esterifying the phenolic hydroxyl group of salidroside with benzoyl chloride, was one of five derivatives that were more cytoprotective than salidroside, with an EC50 of 0.038 mM versus 0.30 mu M for salidroside. pOBz was also more lipophilic, with log P of 1.44 versus -0.89 for salidroside. Reverse virtual docking predicted that pOBz would bind strongly with monoamine oxidase (MAO) B by occupying its entrance and substrate cavities, and by interacting with the inter-cavity gating residue Ile199 and Tyr435 of the substrate cavity. Enzymatic studies confirmed that pOBz competitively inhibited the activity of purified human MAO-B (K-i = 0.041 mu M versus Ki = 0.92 mu M for salidroside), and pOBz was highly selective for MAO-B over MAO-A. In vivo, pOBz inhibited cerebral MAO activity after middle cerebral artery occlusion with reperfusion in rats, and it reduced cerebral infarct volume, improved neurological function and NeuN expression, and inhibited complement C3 expression and apoptosis. Our results suggest that pOBz is a structurally novel type of competitive and selective MAO-B inhibitor, with potent neuroprotective properties after cerebral ischemia-reperfusion injury in rats. (C) 2020 Elsevier Masson SAS. All rights reserved.
C1 [Yang, Zelin; Huang, Xin; Lai, Wenfang; Tang, Yuheng; Liu, Junjie; Wang, Yingzheng; Chu, Kedan; Brown, John; Hong, Guizhu] Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Hong, GZ (corresponding author), Fujian Univ Tradit Chinese Med, 1 Huatou Rd, Fuzhou, Peoples R China.
EM guizhuhong@fjtcm.edu.cn
OI Liu, Junjie/0000-0002-4236-1803; Hong, Guizhu/0000-0003-3932-4777
FU National Natural Science Foundation of China [81973503]; Natural Science
   Foundation of Fujian Province, China [2019J01345]
FX This work was supported by the National Natural Science Foundation of
   China (Project 81973503), and by the Natural Science Foundation of
   Fujian Province, China (Project 2019J01345). The authors thank the staff
   in the Animal Center of the Fujian University of Traditional Chinese
   Medicine for their technical support.
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NR 52
TC 26
Z9 29
U1 2
U2 49
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD JAN 1
PY 2021
VL 209
AR 112935
DI 10.1016/j.ejmech.2020.112935
PG 15
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA PH4XW
UT WOS:000600418500069
PM 33097301
DA 2026-05-27
ER

PT J
AU Guan, S
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AF Guan, Shuang
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   Qian, Wenhui
   Huang, Guoren
   Deng, Xuming
   Wang, Xuelin
TI Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a
   cAMP-Dependent Pathway
SO MOLECULES
LA English
DT Article
DE salidroside; antioxidant; AMP; cGMP; [Ca2+]i; ROS
ID ISCHEMIA/REPERFUSION INJURY; RHODIOLA-ROSEA; IN-VITRO; APOPTOSIS;
   KINASE; MICE; CGMP
AB Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H2O2)-induced HL-7702 cell damage, inhibit H2O2-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3'-5'-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn't influence 3'-5'-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+] i, ROS occur via a cAMP-dependent pathway.
C1 [Guan, Shuang; Wang, Wei; Lu, Jing; Deng, Xuming; Wang, Xuelin] Jilin Univ, Coll Anim Sci & Vet Med, Inst Zoonoses, Changchun 130062, Jilin, Peoples R China.
   [Lu, Jing; Qian, Wenhui; Huang, Guoren] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Deng, XM (corresponding author), Jilin Univ, Coll Anim Sci & Vet Med, Inst Zoonoses, Changchun 130062, Jilin, Peoples R China.
EM gshuang1973@126.com; wangwei@jluhp.edu.cn; xlujing1@yahoo.com.cn;
   xumingdeng@yahoo.com.cn; wxlwqx@sohu.com
RI Wang, Wei/LUY-9636-2024; Guan, Shuang/JXN-9245-2024
OI Wang, Wei/0000-0001-7273-866X; 
FU Chinese postdoctoral station of Jilin University [801091800604]
FX This study was financed by the Chinese postdoctoral station of Jilin
   University (Number 801091800604).
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NR 27
TC 18
Z9 23
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2011
VL 16
IS 4
BP 3371
EP 3379
DI 10.3390/molecules16043371
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 755YE
UT WOS:000289976200024
PM 21512445
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, XM
   Xie, L
   Long, JY
   Xie, QX
   Zheng, Y
   Liu, K
   Li, XF
AF Zhang, Xumin
   Xie, Long
   Long, Jiaying
   Xie, Qingxuan
   Zheng, Yu
   Liu, Kai
   Li, Xiaofang
TI Salidroside: A review of its recent advances in synthetic pathways and
   pharmacological properties
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Review
DE Salidroside; Synthesis; Pharmacology; Mechanisms; Pharmacokinetics;
   Toxicology
ID RHODIOLA-ROSEA-L.; MESENCHYMAL STEM-CELLS; INDUCED RAT MODEL;
   FACTOR-KAPPA-B; OXIDATIVE STRESS; IN-VITRO; ENDOTHELIAL-CELLS;
   ISCHEMIA/REPERFUSION INJURY; QUANTITATIVE-DETERMINATION; PREMATURE
   SENESCENCE
AB Salidroside has been identified as one of the most potent compounds isolated from various Rhodiola plants, which have been used for a long time as adaptogens in traditional Chinese medicine. However, due to the severe growing environment of herbal medicine and large-scale excavation, the content of natural salidroside is extremely small. Most of the previous studies focused on herbal medicine, and there were few reviews on the synthesis of its main active ingredient salidroside. This paper presents different synthetic routes of salidroside to resolve the contradiction between supply and demand and lays the foundation for new drug research and development. Furthermore, emerging evidence indicates that salidroside, a promising environmentally-adapted drug with low toxicity and few side effects, possesses a wide spectrum of pharmacological properties, including activities on the cardiovascular system and central nervous system, anti-hypoxia, anti-fatigue and anti-aging activities, anticancer activity, anti-inflammatory activity, antioxidant activity, antivirus and immune stimulation activities, antidiabetic activity, anti-osteoporotic activity, and so on. Although the former researches have summarized the pharmacological effects of salidroside, focusing on the central nervous system, diabetes, and cancer, the overall pharmacological aspects of it have not been analyzed. This review highlights biological characteristics and mechanisms of action from 2009 to now as well as toxicological and pharmacokinetic data of the analyzed compound reported so far, with a view to providing a reference for further development and utilization of salidroside.
C1 [Zhang, Xumin; Xie, Long; Long, Jiaying; Xie, Qingxuan; Zheng, Yu; Liu, Kai; Li, Xiaofang] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Li, XF (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
EM zhangxumin97@163.com; xielong@stu.cdutcm.edu.cn; 1442738358@qq.com;
   635544103@qq.com; zhengyu11zzzz@163.com; charliekk@stu.cdutcm.edu.cn;
   lixiaofang@cdutcm.edu.cn
RI ; xie, long/GQP-3224-2022; Long, Jiaying/OTJ-0849-2025
OI Liu, Kai/0000-0001-5336-7939; xie, long/0000-0002-4016-8655; 
FU Department of Science and Technology of Sichuan Province [2019YFS0113];
   State Administration of Traditional Chinese Medicine of the People's
   Republic of China [2018ZYO3O02]
FX This work was supported by the Department of Science and Technology of
   Sichuan Province (No. 2019YFS0113) and the State Administration of
   Traditional Chinese Medicine of the People's Republic of China (No.
   2018ZYO3O02).
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U2 279
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD APR 25
PY 2021
VL 339
AR 109268
DI 10.1016/j.cbi.2020.109268
EA MAR 2021
PG 20
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA RI2IT
UT WOS:000636733900001
PM 33617801
DA 2026-05-27
ER

PT J
AU Liu, ZH
   Chen, LX
   Xiong, DF
   Zhan, Y
   Liu, JD
   Ouyang, L
   Chen, WC
   Lu, ZY
   Gao, TQ
   Li, XZ
   Zhou, YQ
   Gu, XK
   Xiao, Y
AF Liu, Zenghui
   Chen, Lixuan
   Xiong, Defang
   Zhan, Yu
   Liu, Jiduo
   Ouyang, Ling
   Chen, Wancheng
   Lu, Ziyuan
   Gao, Tianqi
   Li, Xiaozhen
   Zhou, Yanqun
   Gu, Xuekui
   Xiao, Yang
TI Salidroside affects the Th17/Treg cell balance in aplastic anemia via
   the STAT3/HIF-1a/ROR?t pathway
SO REDOX REPORT
LA English
DT Article
DE Salidroside; Th17/Treg balance; STAT3/HIF-1a/ROR?t pathway; aplastic
   anemia
ID OXIDATIVE STRESS; RHODIOLA-ROSEA; MTOR PATHWAY; T-CELLS; STAT3;
   PROTECTS; IL-6; GROWTH; EXPRESSION; INDUCTION
AB Background: Acquired aplastic anemia (AA) is a life-threatening disease associated with an imbalance in Th17/Treg cells. Regulating this balance may be an effective treatment approach for AA. Rhodiola rosea has shown efficacy in AA treatment, but its mechanisms remain unclear.Purpose: We investigated salidroside's effect (a component of Rhodiola rosea) on Th17/Treg balance in adult AA patients and a mouse model.Methods: HIF-1a mRNA and protein levels were measured in AA patients' peripheral blood. Flow cytometry, qRT-PCR, and WB analyzed salidroside's impact on T cell differentiation, Th17 cells, Treg cells, STAT3, HIF-1a, and ROR?t expression. ELISA measured hematopoietic growth factors in mouse serum.Results: AA patients exhibited elevated HIF-1a levels. Salidroside improved hematopoietic function, increasing blood cell count and enhancing bone marrow. Salidroside induced SCF, TPO, and IL-3 expression while inhibiting IL-2 in mice. Salidroside reduced STAT3, HIF-1a, ROR?t, and IL-17a, while increasing FoxP3 expression, correcting the Th17/Treg imbalance in vitro and in vivo.Conclusion: Salidroside has potential as a novel AA treatment by correcting the Th17/Treg imbalance through the STAT3/HIF-1a/ROR?t pathway.
C1 [Liu, Zenghui; Chen, Lixuan; Gao, Tianqi; Li, Xiaozhen; Zhou, Yanqun; Xiao, Yang] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
   [Liu, Zenghui; Liu, Jiduo; Gu, Xuekui] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Hematol, Guangzhou, Peoples R China.
   [Xiong, Defang] Guangzhou Chest Hosp, Dept Pathol, Guangzhou, Peoples R China.
   [Zhan, Yu] Guangzhou Twelfth Peoples Hosp, Dept Hematol, Guangzhou, Peoples R China.
   [Ouyang, Ling] Southern Theater Gen Hosp, Dept Hematol, Guangzhou, Peoples R China.
   [Chen, Wancheng] Southern Med Univ, Zhujiang Hosp, Dept Radiotherapy, Guangzhou, Peoples R China.
   [Lu, Ziyuan] Guangzhou Med Univ, Affiliated Hosp 3, Dept Hematol, Guangzhou, Peoples R China.
   [Xiao, Yang] Shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, Shenzhen, Peoples R China.
   [Xiao, Yang] Shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, 36 Shekou Ind Seventh Rd, Shenzhen 518101, Guangdong, Peoples R China.
   [Gu, Xuekui] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Hematol, 16 Jichang Rd, Guangzhou 510405, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Southern Medical University - China; Guangzhou Medical
   University; Guangzhou University of Chinese Medicine
RP Xiao, Y (corresponding author), Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.; Xiao, Y (corresponding author), Shenzhen Qianhai Shekou Pilot Free Trade Zone Hosp, Dept Hematol, 36 Shekou Ind Seventh Rd, Shenzhen 518101, Guangdong, Peoples R China.; Gu, XK (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Hematol, 16 Jichang Rd, Guangzhou 510405, Guangdong, Peoples R China.
EM guxuekui1067@163.com; jdxiao111@163.com
RI Liu, Zenghui/GVR-9421-2022
FU National Natural Science Foundation of China [81903973, 81873426];
   Guangdong Traditional Chinese Medicine Bureau [20202064]; Youth Research
   Fund Project of the Innovation to Strengthen Hospital Project of The
   First Affiliated Hospital of Guangzhou University of Chinese Medicine
   [2019QN03]; Science and Technology Innovation Strategy Special Fund of
   Guangdong Province [2019A1515010390]; Shenzhen Science and Technology
   Program [JCYJ20220530151613030]; Nanshan District Technology Research
   and Creative Design Project, Shenzhen City [NS2022004]
FX This work was supported by funding from the National Natural Science
   Foundation of China (project no. 81903973, project no. 81873426),
   Guangdong Traditional Chinese Medicine Bureau (project no. 20202064),
   Youth Research Fund Project of the Innovation to Strengthen Hospital
   Project of The First Affiliated Hospital of Guangzhou University of
   Chinese Medicine (project no. 2019QN03) and Science and Technology
   Innovation Strategy Special Fund of Guangdong Province (project no.
   2019A1515010390). Shenzhen Science and Technology Program (project no.
   JCYJ20220530151613030), Sub-item funding for health science and
   technology projects under the Nanshan District Technology Research and
   Creative Design Project, Shenzhen City (project no. NS2022004).
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PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD DEC 31
PY 2023
VL 28
IS 1
AR 2225868
DI 10.1080/13510002.2023.2225868
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA M3TP6
UT WOS:001029450100001
PM 37439434
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Huang, XJ
   Xing, SL
   Chen, C
   Yu, ZH
   Chen, JL
AF Huang, Xujiao
   Xing, Sanli
   Chen, Chuan
   Yu, Zhihua
   Chen, Jiulin
TI Salidroside protects PC12 cells from Aβ1-40-induced
   cytotoxicity by regulating the nicotinamide phosphoribosyltransferase
   signaling pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE Alzheimer's disease; salidroside; amyloid beta-protein(1-40);
   nicotinamide phosphoribosyltransferase; nicotinamide adenine
   dinucleotide
ID ALZHEIMERS-DISEASE; REDOX STATE; HIPPOCAMPAL; NAD(+); NEURODEGENERATION;
   PGC-1-ALPHA; ACTIVATION; EXPRESSION; PI3K/AKT; NEURONS
AB Alzheimer's disease (AD) is the most common type of senile dementia, which often develops in elderly or presenile individuals. As one of the pathological features of AD, amyloid beta-protein (A beta) causes energy dysmetabolism, thereby inducing cellular damage and apoptosis. Salidroside is the main active component of the traditional Chinese medicine Rhodiola. Previous studies have demonstrated that salidroside exerts a regulatory role in energy metabolism. However, the role and the mechanism of action of salidroside in AD remain unclear. Therefore, the present study used A beta(1-40) to induce damage in PC12 cells, thereby establishing a cell model of AD. In addition, salidroside treatment was performed to investigate the protective effect of salidroside and the underlying mechanisms. A beta(1-40)-induced neuronal toxicity reduced cell viability and caused cellular damage. As a result, the expression level of nicotinamide phosphoribosyltransferase (NAMPT) decreased, the synthesis of nicotinamide adenine dinucleotide (NAD(+); an energy metabolism-associated coenzyme) became insufficient, and the NAD+/nicotinamide adenine dinucleotide hydride ratio was reduced. Administration of salidroside alleviated A beta-induced cell damage and increased the expression level of the key protein NAMPT and the synthesis of NAD(+). The results of the present study demonstrate that salidroside exerts a protective effect on A beta(1-40)-damaged PC12 cells. The underlying mechanism may be associated with the regulation of energy metabolism that relies predominantly on the NAMPT signaling pathway.
C1 [Huang, Xujiao; Xing, Sanli; Chen, Chuan; Yu, Zhihua; Chen, Jiulin] Shanghai Univ Tradit Chinese Med, Shanghai Geriatr Inst Chinese Med, Geriatr Lab, 365C Souh Xiangyang Rd, Shanghai 200031, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Xing, SL (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Geriatr Inst Chinese Med, Geriatr Lab, 365C Souh Xiangyang Rd, Shanghai 200031, Peoples R China.
EM xingsanli@163.com
RI ; Yu, ZH/KBC-6889-2024
OI CHEN, CHUAN/0000-0003-1132-7706; 
FU National Natural Science Foundation of China [81503626]; Shanghai Health
   Bureau Youth Fund [201540254, 20134331]
FX The present study was supported by grants from the National Natural
   Science Foundation of China (grant no. 81503626) and the Shanghai Health
   Bureau Youth Fund (grant nos. 201540254 and 20134331).
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NR 42
TC 15
Z9 16
U1 1
U2 26
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD SEP
PY 2017
VL 16
IS 3
BP 2700
EP 2706
DI 10.3892/mmr.2017.6931
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FD3VX
UT WOS:000407461600042
PM 28714019
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Chen, CG
   Tang, YH
   Deng, W
   Huang, CX
   Wu, TY
AF Chen, Changgui
   Tang, Yanhong
   Deng, Wet
   Huang, Congxin
   Wu, Tianyi
TI Salidroside blocks the proliferation of pulmonary artery smooth muscle
   cells induced by platelet-derived growth factor-BB
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; proliferation; pulmonary artery smooth muscle cells;
   platelet-derived growth factor-BB
ID CYCLE; SUPPRESSION; ACTIVATION; EXPRESSION; APOPTOSIS; PROTECTS;
   EXTRACT; ARREST; INJURY
AB The proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the development of pulmonary vascular remodeling, ultimately leading to pulmonary hypertension. In this study, the effects and molecular mechanisms of salidroside on the platelet-derived growth factor (PDGF)-BB-induced proliferation of primary cultured rat PASMCs were investigated. The presented data demonstrated that salidroside significantly inhibited the proliferation and DNA synthesis of PASMCs induced by PDGF-BB in a dose- and time-dependent manner, without cell cytotoxicity. In accordance with these findings, salidroside blocked progression through G0/G1 to S phase of the cell cycle. The salidroside-induced inhibition of the cell cycle was associated with the inhibition of cyclin D1, cyclin E, cyclin-dependent kinase 2 (CDK2) and CDK4 mRNA expression, as well as an increase in the mRNA expression of p27 in PDGF-BB-stimulated PASMCs. Further experiments showed that the beneficial effect of salidroside on blocking the proliferation of PASMCs was associated with the suppression of the AKT/glycogen synthase kinase 3 beta (GSK3 beta) signaling pathway, but did not involve the extracellular signal-regulated kinase 1/2, p38 and c-Jun-N-terminal kinase signaling pathways. These results indicate that salidroside suppresses PDGF-BB-induced PASMC proliferation through the AKT/GSK3 beta signaling pathway and suggests that it may be a feasible therapy for pulmonary vascular remodeling diseases.
C1 [Chen, Changgui; Tang, Yanhong; Deng, Wet; Huang, Congxin; Wu, Tianyi] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.
   [Chen, Changgui; Tang, Yanhong; Deng, Wet; Huang, Congxin; Wu, Tianyi] Wuhan Univ, Cardiovasc Res Inst, Wuhan 430060, Hubei, Peoples R China.
   [Wu, Tianyi] High Altitude Med Res Inst, Xining 810012, Qinghai, Peoples R China.
C3 Wuhan University; Wuhan University
RP Wu, TY (corresponding author), Wuhan Univ, Dept Cardiol, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
EM wutianyiqh@hotmail.com
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NR 31
TC 17
Z9 20
U1 0
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD AUG
PY 2014
VL 10
IS 2
BP 917
EP 922
DI 10.3892/mmr.2014.2238
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AL4TL
UT WOS:000339127600052
PM 24840151
OA Bronze
DA 2026-05-27
ER

PT J
AU Li, LY
   Yang, YY
   Zhang, HA
   Du, YH
   Jiao, XL
   Yu, HH
   Wang, Y
   Lv, QW
   Li, F
   Sun, QJ
   Qin, YW
AF Li, Linyi
   Yang, Yunyun
   Zhang, Huina
   Du, Yunhui
   Jiao, Xiaolu
   Yu, Huahui
   Wang, Yu
   Lv, Qianwen
   Li, Fan
   Sun, Qiuju
   Qin, Yanwen
TI Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial
   Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA
   Signaling Pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE atherosclerosis; obstructive sleep apnea-hypopnea syndrome; intermittent
   hypoxia; salidroside; endothelial barrier
ID OBSTRUCTIVE SLEEP-APNEA; POSITIVE AIRWAY PRESSURE; INTIMA-MEDIA
   THICKNESS; DYSFUNCTION; RHODIOLA; HYPERTENSION; MECHANISMS; EXPRESSION;
   APOPTOSIS; DISEASE
AB Background: Endothelial barrier dysfunction plays a key role in atherosclerosis progression. The primary pathology of obstructive sleep apnea-hypopnea syndrome is chronic intermittent hypoxia (IH), which induces reactive oxygen species (ROS) overproduction, endothelial barrier injury, and atherosclerosis. Salidroside, a typical pharmacological constituent of Rhodiola genus, has documented antioxidative, and cardiovascular protective effects. However, whether salidroside can improve IH-aggravated endothelial barrier dysfunction and atherosclerosis has not been elucidated.Methods and results: In normal chow diet-fed ApoE(-/-) mice, salidroside (100 mg/kg/d, p. o.) significantly ameliorated the formation of atherosclerotic lesions and barrier injury aggravated by 7-weeks IH (21%-5%-21%, 120 s/cycle). In human umbilical vein endothelial cells (HUVECs), exposure to IH (21%-5%-21%, 40 min/cycle, 72 cycles) decreased transendothelial electrical resistance and protein expression of vascular endothelial cadherin (VE-cadherin) and zonula occludens 1. In addition, IH promoted ROS production and activated ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK) pathway. All of these effects of IH were reversed by salidroside. Similar to salidroside, ROCK-selective inhibitors Y26732, and Fasudil protected HUVECs from IH-induced ROS overproduction and endothelial barrier disruption. Furthermore, salidroside increased intracellular cAMP levels, while the PKA-selective inhibitor H-89 attenuated the effects of salidroside on IH-induced RhoA/ROCK suppression, ROS scavenging, and barrier protection.Conclusion: Our findings demonstrate that salidroside effectively ameliorated IH-aggravated endothelial barrier injury and atherosclerosis, largely through the cAMP/PKA/RhoA signaling pathway.
C1 [Li, Linyi; Yang, Yunyun; Zhang, Huina; Du, Yunhui; Jiao, Xiaolu; Yu, Huahui; Wang, Yu; Lv, Qianwen; Li, Fan; Sun, Qiuju; Qin, Yanwen] Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Key Lab Upper Airway Dysfunct Related Cardiovasc, Beijing, Peoples R China.
   [Li, Linyi; Yang, Yunyun; Zhang, Huina; Du, Yunhui; Jiao, Xiaolu; Yu, Huahui; Wang, Yu; Lv, Qianwen; Li, Fan; Sun, Qiuju; Qin, Yanwen] Capital Med Univ, Beijing Anzhen Hosp, Minist Educ, Key Lab Remodeling Related Cardiovasc Dis, Beijing, Peoples R China.
   [Li, Linyi; Yang, Yunyun; Zhang, Huina; Du, Yunhui; Jiao, Xiaolu; Yu, Huahui; Wang, Yu; Lv, Qianwen; Li, Fan; Sun, Qiuju; Qin, Yanwen] Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Qin, YW (corresponding author), Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Key Lab Upper Airway Dysfunct Related Cardiovasc, Beijing, Peoples R China.; Qin, YW (corresponding author), Capital Med Univ, Beijing Anzhen Hosp, Minist Educ, Key Lab Remodeling Related Cardiovasc Dis, Beijing, Peoples R China.; Qin, YW (corresponding author), Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China.
EM qinyanwen@vip.126.com
RI ; Li, Linyi/LCD-9244-2024
OI Jiao, Xiaolu/0000-0001-6550-8321; Li, Linyi/0000-0003-0243-6193
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NR 59
TC 40
Z9 50
U1 3
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 24
PY 2021
VL 12
AR 723922
DI 10.3389/fphar.2021.723922
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XM4ZR
UT WOS:000728837700001
PM 34504429
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tang, HY
   Gao, LL
   Mao, JW
   He, HY
   Liu, J
   Cai, X
   Lin, HL
   Wu, TH
AF Tang, Haiying
   Gao, Lili
   Mao, Jingwei
   He, Huanyu
   Liu, Jia
   Cai, Xin
   Lin, Hongli
   Wu, Taihua
TI Salidroside protects against bleomycin-induced pulmonary fibrosis:
   activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and
   TGF-β1/Smad-2/-3 pathways
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Salidroside; Pulmonary fibrosis; EMT; NF-kappa B p65 signaling pathway;
   Nrf2 signaling pathway; TGF-beta 1/Smad2/3 signaling pathway
ID EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE LUNG INJURY; OXIDATIVE STRESS;
   RANDOMIZED-TRIAL; RHODIOLA-ROSEA; MECHANISMS; NRF2; ACETYLCYSTEINE;
   PATHOGENESIS; CELLS
AB Pulmonary fibrosis (PF) can severely disrupt lung function, leading to fatal consequences. Salidroside is a principal active ingredient of Rhodiola rosea and has recently been reported to protect against lung injures. The present study was aimed at exploring its therapeutic effects on PF. Lung fibrotic injuries were induced in SD rats by a single intratracheal instillation of 5 mg/kg bleomycin (BLM). Then, these rats were administrated with 50, 100, or 200 mg/kg salidroside for 28 days. BLM-triggered structure distortion, collagen overproduction, excessive inflammatory infiltration, and pro-inflammatory cytokine release, and oxidative stress damages in lung tissues were attenuated by salidroside in a dose-dependent manner. Furthermore, salidroside was noted to inhibit I kappa B alpha phosphorylation and nuclear factor kappa B (NF-kappa B) p65 nuclear accumulation while activating Nrf2-antioxidant signaling in BLM-treated lungs. Downregulation of E-cadherin and upregulation of vimentin, fibronectin, and alpha-smooth muscle actin (alpha-SMA) indicated an epithelial-mesenchymal transition (EMT)-like shift in BLM-treated lungs. These changes were suppressed by salidroside. The expression of TGF-beta 1 and the phosphorylation of its downstream targets, Smad-2/-3, were enhanced by BLM, but weakened by salidroside. Additionally, salidroside was capable of reversing the recombinant TGF-beta 1-induced EMT-like changes in alveolar epithelial cells in vitro. Our study reveals that salidroside's protective effects against fibrotic lung injuries are correlated to its anti-inflammatory, antioxidative, and antifibrotic properties.
C1 [Tang, Haiying; Gao, Lili; He, Huanyu; Liu, Jia; Wu, Taihua] Dalian Med Univ, Affiliated Hosp 1, Dept Resp Med, 222 Zhongshan Rd, Dalian 116011, Peoples R China.
   [Mao, Jingwei] Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, 222 Zhongshan Rd, Dalian 116011, Peoples R China.
   [Cai, Xin] Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, 222 Zhongshan Rd, Dalian 116011, Peoples R China.
   [Lin, Hongli] Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, 222 Zhongshan Rd, Dalian 116011, Peoples R China.
C3 Dalian Medical University; Dalian Medical University; Dalian Medical
   University; Dalian Medical University
RP Wu, TH (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Resp Med, 222 Zhongshan Rd, Dalian 116011, Peoples R China.; Lin, HL (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, 222 Zhongshan Rd, Dalian 116011, Peoples R China.
EM linhongli@vip.163.com; wutaihua@sina.com
RI ; Cai, Xin/AAH-6432-2021; /J-1197-2016
OI Mao, Jingwei/0000-0003-1896-1988; 
FU National Nature Science Foundation of China [81273924]; Nature Science
   Foundation of Liaoning Province [2013023028]
FX This study was supported by grants from the National Nature Science
   Foundation of China (No. 81273924) and the Nature Science Foundation of
   Liaoning Province (No. 2013023028).
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NR 41
TC 89
Z9 101
U1 0
U2 29
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD MAR
PY 2016
VL 21
IS 2
BP 239
EP 249
DI 10.1007/s12192-015-0654-4
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DG7QL
UT WOS:000372278700005
PM 26577463
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Yang, RL
   Wang, Y
   Zhao, XJ
   Tong, Z
   Zhu, QL
   He, XX
   Wang, ZY
   Luo, HZ
   Fang, F
AF Yang, Rongling
   Wang, Yu
   Zhao, Xiangjie
   Tong, Zheng
   Zhu, Qianlin
   He, Xiaoxi
   Wang, Zhaoyu
   Luo, Hongzhen
   Fang, Fang
TI A facile and efficient synthesis approach of salidroside esters by
   whole-cell biocatalysts in organic solvents
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE salidroside esters; whole-cells; biocatalysis; acyl donor specificity;
   organic solvents
ID HIGHLY EFFICIENT; ACYLATION; LIPASE
AB Salidroside, the main bioactive compound isolated from the plant source of Rhodiola rosea L, possesses broad-spectrum pharmacological activities, but suffers from the low cell membranes permeability and alimentary absorption due to its high polarity. Therefore, a whole-cell catalytic strategy for the synthesis of salidroside esters was explored to improve its lipophilicity. The results showed that Aspergillus oryzae demonstrated the highest biocatalytic activity among the microbial strains tested. For the synthesis of salidroside caprylate, the optimum conditions of reaction medium, Aspergillus oryzae amount, molar ratio of vinyl caprylate to salidroside and reaction temperature were acetone, 30 mg/ml, 10 degrees C and 40 degrees C, respectively. Under these conditions, the initial reaction rate was 15.36 mM/h, and substrate conversion and regioselectivity all reached 99%. Moreover, the results indicated that although various 6'-monoesters derivatives of salidroside were exclusively obtained with excellent conversions (96%-99%), the reaction rate varied greatly with different chain-length acyl donors. This study details an efficient and cost-effective biocatalytic approach for the synthesis of salidroside esters by using Aspergillus oryzae as a catalyst for the first time. Considering the whole cell catalytic efficiency and operational stability, this strategy may provide a new opportunity to develop green industrial processes production for ester derivatives of salidroside and its analogues.
C1 [Yang, Rongling; Wang, Yu; Zhao, Xiangjie; Tong, Zheng; Zhu, Qianlin; He, Xiaoxi; Wang, Zhaoyu; Luo, Hongzhen; Fang, Fang] Huaiyin Inst Technol, Sch Life Sci & Food Engn, Huaian, Peoples R China.
C3 Huaian University
RP Zhao, XJ (corresponding author), Huaiyin Inst Technol, Sch Life Sci & Food Engn, Huaian, Peoples R China.
EM zhaoxiangjie@hyit.edu.cn
RI Luo, Hongzhen/P-4730-2019
FU National Natural Science Foundation of China; Six Talent Peaks of
   Jiangsu Province;  [21706088];  [2018-SWYY-020]
FX Funding We thank the financial support from the National Natural Science
   Foundation of China (21706088) and the Six Talent Peaks of Jiangsu
   Province (2018-SWYY-020).
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NR 30
TC 6
Z9 7
U1 1
U2 36
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD NOV 24
PY 2022
VL 10
AR 1051117
DI 10.3389/fbioe.2022.1051117
PG 8
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6U6RE
UT WOS:000894490800001
PM 36507279
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, LW
   Zhou, R
   Sui, JL
   Liu, YJ
AF Sun, Liwei
   Zhou, Ran
   Sui, Jinling
   Liu, Yujun
TI Simultaneous Preparation of Salidroside and p-Tyrosol from
   Rhodiola crenulata by DIAION HP-20 Macroporous Resin
   Chromatography Combined with Silica Gel Chromatography
SO MOLECULES
LA English
DT Article
DE salidroside; p-tyrosol; DIAION HP-20 adsorption column chromatography;
   silica gel column chromatography; UPLC
ID FOURIER-TRANSFORM; H9C2 CELLS; ADSORPTION; PURIFICATION; PHENOLICS;
   EXTRACT; INJURY; ROSEA; SACHALINENSIS; IMPAIRMENT
AB The Rhodiola species have a long history of utilization in traditional medicine and have been considered as a source of adaptation to environmental challenges; salidroside and p-tyrosol are the major responsible compounds. Here we propose a novel UPLC-guided two-step method consisting of a DIAION HP-20 adsorption and silica gel column chromatographies, which can simultaneously prepare high purities of salidroside and p-tyrosol with noticeable yields from the rhizome of Rhodiola crenulata. Results demonstrated that DIAION HP-20 could successfully remove all impurities except crenulatin during a gradient elution with 5-20% ethanol, which could achieve an optimal purification of salidroside and p-tyrosol with increasing rates of 29.19% and 33.44%, respectively. Furthermore, chloroform was selected as an ideal solvent for separating p-tyrosol with salidroside, and thus crenulatin was subsequently applied in the silica gel chromatography, and the separation of salidroside with crenulatin could be achieved using silica gel chromatography with a mixture of chloroform and methanol at a volume ratio of 4:1. High purity rates of 94.17% and 97.29% and overall yields of 39.09% and 43.73% for salidroside and p-tyrosol were simultaneously achieved. Our method provides a new way to simultaneously obtain salidroside and p-tyrosol from R. Crenulata, as well as other related plant species.
C1 [Sun, Liwei; Liu, Yujun] Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Natl Engn Lab Tree Breeding, Beijing 100083, Peoples R China.
   [Zhou, Ran; Sui, Jinling] Beijing Forestry Univ, Sch Nat Conservat, Beijing 100083, Peoples R China.
C3 Beijing Forestry University; Beijing Forestry University
RP Liu, YJ (corresponding author), Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Natl Engn Lab Tree Breeding, Beijing 100083, Peoples R China.; Sui, JL (corresponding author), Beijing Forestry Univ, Sch Nat Conservat, Beijing 100083, Peoples R China.
EM lsun2013@bjfu.edu.cn; zhouransha@163.com; jlsui@bjfu.edu.cn;
   yjliubio@bjfu.edu.cn
RI ; Liu, Yujun/H-3661-2015
OI Sui, Jinling/0000-0002-1145-6017; Liu, Yujun/0000-0001-6588-3359
FU Fundamental Research Funds for the Central Universities [BLX2013025]
FX This research was funded by the Fundamental Research Funds for the
   Central Universities (BLX2013025).
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NR 39
TC 13
Z9 13
U1 8
U2 34
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2018
VL 23
IS 7
AR 1602
DI 10.3390/molecules23071602
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GU5CE
UT WOS:000445301800105
PM 30004426
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ji, R
   Jia, FY
   Chen, X
   Wang, ZH
   Jin, WY
   Yang, J
AF Ji, Rui
   Jia, Fang-yuan
   Chen, Xin
   Wang, Ze-hao
   Jin, Wen-yi
   Yang, Jing
TI Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2
   pathway in DHT-induced human granulosa cell line KGN
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Salidroside; Polycystic ovary syndrome; Oxidative stress; Nrf2; AMPK
ID RHODIOLA-ROSEA L.; REDOX BIOLOGY; HORMONE; GLUCOSE; NRF2
AB In the past few years, emerging evidence established persistent oxidative stress to be a key player in the pathogenesis of polycystic ovary syndrome (PCOS). Particularly, it damages the function of granulosa cells, and thus hinders the development of follicles. The present study aimed to explore and establish the protective effects of salidroside on dihydrotestosterone (DHT)-induced Granulosa-like tumor cell line (KGN), mediated via antioxidant mechanisms. The study assessed the positive effects of salidroside on DHT-induced apoptosis, reactive oxygen species (ROS) accumulation, damage of antioxidant capacity, and mitochondrial membrane potential depolarization. Interestingly, salidroside partly reversed DHT mediated effects, via stimulation of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and the downstream antioxidant proteins heme oxygenase1(HO-1) and quinine oxidoreductase 1(NQO1). Additionally, the knockdown of Nrf2 partly moderated the antioxidant and anti-apoptosis effects of salidroside in DHT-treated KGN cells. Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1. Altogether, the present study is the first to effectively demonstrate the inhibitory effect of salidroside on DHT-stimulated oxidative stress and apoptosis in KGN cells, which was dependent on Nrf2 activation that involved AMPK.
C1 [Ji, Rui; Chen, Xin; Wang, Ze-hao; Jin, Wen-yi; Yang, Jing] Wuhan Univ, Reprod Med Ctr, Renmin Hosp, Wuhan, Peoples R China.
   [Ji, Rui; Chen, Xin; Wang, Ze-hao; Jin, Wen-yi; Yang, Jing] Hubei Clin Res Ctr Assisted Reprod Technol & Embr, Wuhan, Peoples R China.
   [Jia, Fang-yuan] Henan Prov Peoples Hosp, Dept Vasc & Endovasc Surg, Zhengzhou, Henan, Peoples R China.
   [Jia, Fang-yuan] Zhengzhou Univ, Dept Aort Surg, Cent China Fuwai Hosp, Zhengzhou, Henan, Peoples R China.
C3 Wuhan University; Zhengzhou University; Zhengzhou University
RP Yang, J (corresponding author), Wuhan Univ, Reprod Med Ctr, Renmin Hosp, Wuhan, Peoples R China.
EM dryangjing@whu.edu.cn
RI ; Chen, Xin/OLQ-2691-2025
OI Chen, Xin/0000-0003-3885-4944; 
FU National Natural Science Foundation of China [81971356, 81771662,
   81771618]; National Key Research and Development Program of China
   [2016YFC1000600, 2018YFC1002804]
FX This research was supported by the National Natural Science Foundation
   of China (Grant No. 81971356, 81771662, 81771618) and the National Key
   Research and Development Program of China (No. 2016YFC1000600,
   2018YFC1002804).
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NR 61
TC 70
Z9 73
U1 6
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD JAN 15
PY 2022
VL 715
AR 109094
DI 10.1016/j.abb.2021.109094
EA NOV 2021
PG 13
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA XM1BQ
UT WOS:000728571000003
PM 34813774
DA 2026-05-27
ER

PT J
AU Kallscheuer, N
   Menezes, R
   Foito, A
   da Silva, MH
   Braga, A
   Dekker, W
   Sevillano, DM
   Rosado-Ramos, R
   Jardim, C
   Oliveira, J
   Ferreira, P
   Rocha, I
   Silva, AR
   Sousa, M
   Allwood, JW
   Bott, M
   Faria, N
   Stewart, D
   Ottens, M
   Naesby, M
   dos Santos, CN
   Marienhagen, J
AF Kallscheuer, Nicolai
   Menezes, Regina
   Foito, Alexandre
   da Silva, Marcelo Henriques
   Braga, Adelaide
   Dekker, Wijbrand
   Sevillano, David Mendez
   Rosado-Ramos, Rita
   Jardim, Carolina
   Oliveira, Joana
   Ferreira, Patricia
   Rocha, Isabel
   Silva, Ana Rita
   Sousa, Marcio
   Allwood, J. William
   Bott, Michael
   Faria, Nuno
   Stewart, Derek
   Ottens, Marcel
   Naesby, Michael
   dos Santos, Claudia Nunes
   Marienhagen, Jan
TI Identification and Microbial Production of the Raspberry Phenol
   Salidroside that Is Active against Huntington's Disease
SO PLANT PHYSIOLOGY
LA English
DT Article
ID DE-NOVO PRODUCTION; CORYNEBACTERIUM-GLUTAMICUM;
   SACCHAROMYCES-CEREVISIAE; OXIDATIVE STRESS; RESVERATROL PRODUCTION;
   ESCHERICHIA-COLI; YEAST-CELLS; MODEL; EXPRESSION; TOXICITY
AB Edible berries are considered to be among nature's treasure chests as they contain a large number of (poly) phenols with potentially health-promoting properties. However, as berries contain complex (poly) phenol mixtures, it is challenging to associate any interesting pharmacological activity with a single compound. Thus, identification of pharmacologically interesting phenols requires systematic analyses of berry extracts. Here, raspberry (Rubus idaeus, var Prestige) extracts were systematically analyzed to identify bioactive compounds against pathological processes of neurodegenerative diseases. Berry extracts were tested on different Saccharomyces cerevisiae strains expressing disease proteins associated with Alzheimer's, Parkinson's, or Huntington's disease, or amyotrophic lateral sclerosis. After identifying bioactivity against Huntington's disease, the extract was fractionated and the obtained fractions were tested in the yeast model, which revealed that salidroside, a glycosylated phenol, displayed significant bioactivity. Subsequently, a metabolic route to salidroside was reconstructed in S. cerevisiae and Corynebacterium glutamicum. The best-performing S. cerevisiae strain was capable of producing 2.1 mM (640 mg L-1) salidroside from Glc in shake flasks, whereas an engineered C. glutamicum strain could efficiently convert the precursor tyrosol to salidroside, accumulating up to 32 mM (9,700 mg L-1) salidroside in bioreactor cultivations (yield: 0.81 mol mol(-1)). Targeted yeast assays verified that salidroside produced by both organisms has the same positive effects as salidroside of natural origin.
C1 [Kallscheuer, Nicolai; Bott, Michael; Marienhagen, Jan] Forschungszentrum Julich, IBG Biotechnol 1, D-52428 Julich, Germany.
   [Menezes, Regina; Rosado-Ramos, Rita; Jardim, Carolina; dos Santos, Claudia Nunes] iBET, P-2781901 Oeiras, Portugal.
   [Menezes, Regina; Rosado-Ramos, Rita; Jardim, Carolina; dos Santos, Claudia Nunes] Univ Nova Lisboa, Inst Tecnol Quim & Biol Antonio Xavier, P-2780157 Oeiras, Portugal.
   [Foito, Alexandre; Allwood, J. William; Stewart, Derek] James Hutton Inst, Dundee DD2 5DA, Scotland.
   [da Silva, Marcelo Henriques; Sevillano, David Mendez; Ottens, Marcel] Delft Univ Technol, Dept Biotechnol, NL-2629 HZ Delft, Netherlands.
   [Braga, Adelaide; Oliveira, Joana; Ferreira, Patricia; Rocha, Isabel; Silva, Ana Rita; Sousa, Marcio; Faria, Nuno] Biotempo, P-4805017 Guimaraes, Portugal.
   [Braga, Adelaide; Oliveira, Joana; Ferreira, Patricia; Rocha, Isabel; Silva, Ana Rita; Sousa, Marcio; Faria, Nuno] Univ Minho, Ctr Biol Engn, P-4710057 Braga, Portugal.
   [Dekker, Wijbrand; Naesby, Michael] Evolva, CH-4053 Reinach, Switzerland.
   [Bott, Michael; Marienhagen, Jan] Forschungszentrum Julich, Bioecon Sci Ctr BioSC, D-52425 Julich, Germany.
   [Stewart, Derek] Heriot Watt Univ, Inst Mech Proc & Energy Engn, Sch Engn & Phys Sci, Edinburgh, Midlothian, Scotland.
C3 Helmholtz Association; Julich Research Centre; Universidade Nova de
   Lisboa; James Hutton Institute; Delft University of Technology;
   Universidade do Minho; Helmholtz Association; Julich Research Centre;
   Heriot Watt University
RP Marienhagen, J (corresponding author), Forschungszentrum Julich, IBG Biotechnol 1, D-52428 Julich, Germany.; dos Santos, CN (corresponding author), iBET, P-2781901 Oeiras, Portugal.; dos Santos, CN (corresponding author), Univ Nova Lisboa, Inst Tecnol Quim & Biol Antonio Xavier, P-2780157 Oeiras, Portugal.; Marienhagen, J (corresponding author), Forschungszentrum Julich, Bioecon Sci Ctr BioSC, D-52425 Julich, Germany.
EM csantos@itqb.unl.pt; j.marienhagen@fz-juelich.de
RI ; Menezes Echaniz, Regina/L-3792-2014; Braga, Adelaide/J-2340-2014;
   Stewart, Derek/ABB-2248-2021; Bott, Michael/E-8004-2011; Kallscheuer,
   Nicolai/AAF-5247-2020; Rocha, Isabel/A-4279-2013; Menezes Echaniz,
   Regina/L-3792-2014; Mendez Sevillano, David/E-1418-2012; Nunes dos
   Santos, Claudia/H-6476-2016; Marques Silva, Ana Rita/AAA-2309-2022;
   Marienhagen, Jan/E-9593-2011; Allwood, James/AAI-8794-2020; /B-6614-2014
OI Foito, Alexane/0000-0001-6111-5256; Menezes Echaniz,
   Regina/0000-0003-0552-8480; Braga, Adelaide/0000-0001-7432-0726;
   Rosado-Ramos, Rita/0000-0002-1294-9227; Naesby,
   Michael/0000-0001-9422-3077; Bott, Michael/0000-0002-4701-8254;
   Kallscheuer, Nicolai/0000-0003-4925-6923; Rocha,
   Isabel/0000-0001-9494-3410; Ferreira, Patrícia/0000-0002-2292-0874;
   Mendez Sevillano, David/0000-0003-0643-6705; Nunes dos Santos,
   Claudia/0000-0002-5809-1924; Carreira Gomes Jardim, Carolina
   Emanuel/0000-0001-6929-6469; Marienhagen, Jan/0000-0001-5513-3730;
   Allwood, James/0000-0001-6433-2694; Marques Silva, Ana
   Rita/0000-0002-2655-9887
FU European Union Framework Program 7 "BacHBerry" [FP7-613793]; Fundacao
   para a Ciencia e Tecnologia/Ministerio da Educacao e Ciencia, through
   national funds [UID/Multi/04462/2013]; Fundacao para a Ciencia e
   Tecnologia [SFRH/BD/116597/2016, IF/01097/2013]; Portuguese Foundation
   for Science and Technology [UID/BIO/04469]; FEDER; COMPETE 2020
   [POCI-01-0145-FEDER-006684]; European Regional Development Fund under
   the scope of Norte2020 - Programa Operacional Regional do Norte
   [NORTE-01-0145-FEDER-000004]; Bioeconomy Science Center (BioSC);
   Ministry of Innovation, Science and Research of the German State of
   North Rhine-Westphalia within the framework of the NRW Strategieprojekt
   BioSC [313/323-400-00213]; BMBF [031A554]; Rural & Environment Science &
   Analytical Services Division of the Scottish Government; Fundação para a
   Ciência e a Tecnologia [SFRH/BD/116597/2016] Funding Source: FCT
FX This work was supported by the European Union Framework Program 7
   "BacHBerry" (www.bachberry.eu), (Project No. FP7-613793). iNOVA4Health -
   UID/Multi/04462/2013, a program financially supported by Fundacao para a
   Ciencia e Tecnologia/Ministerio da Educacao e Ciencia, through national
   funds and co-funded by FEDER under the PT2020 Partnership Agreement is
   acknowledged. This work was also supported by Fundacao para a Ciencia e
   Tecnologia (SFRH/BD/116597/2016 to R.R-R and IF/01097/2013 to C.N.d.S.).
   A.B., P.F., J.O., A.R.S., N.F., M.S., and I.R. thank the Portuguese
   Foundation for Science and Technology under the scope of the strategic
   funding of UID/BIO/04469 unit, COMPETE 2020 (POCI-01-0145-FEDER-006684)
   and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the
   European Regional Development Fund under the scope of Norte2020 -
   Programa Operacional Regional do Norte. M.B. and J.M. acknowledge the
   financial support of the BOOST fund PNP-EXPRESS kindly funded by the
   Bioeconomy Science Center (BioSC). The scientific activities of the
   BioSC were financially supported by the Ministry of Innovation, Science
   and Research of the German State of North Rhine-Westphalia within the
   framework of the NRW Strategieprojekt BioSC (No. 313/323-400-00213).
   J.M. would also like to thank the BMBF-funded project "BioLiSy"
   (Bioeconomic Lignan Synthesis, funding code 031A554) for financial
   support. D.M.S., A.F., and J.A.W. acknowledge additional part funding
   from the Rural & Environment Science & Analytical Services Division of
   the Scottish Government.
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NR 80
TC 32
Z9 37
U1 2
U2 67
PU AMER SOC PLANT BIOLOGISTS
PI ROCKVILLE
PA 15501 MONONA DRIVE, ROCKVILLE, MD 20855 USA
SN 0032-0889
EI 1532-2548
J9 PLANT PHYSIOL
JI Plant Physiol.
PD MAR
PY 2019
VL 179
IS 3
BP 969
EP 985
DI 10.1104/pp.18.01074
PG 17
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA HM7VW
UT WOS:000459688800017
PM 30397021
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Han, J
   Xiao, Q
   Lin, YH
   Zheng, ZZ
   He, ZD
   Hu, J
   Chen, LD
AF Han, Jing
   Xiao, Qing
   Lin, Yan-hua
   Zheng, Zhen-zhu
   He, Zhao-dong
   Hu, Juan
   Chen, Li-dian
TI Neuroprotective effects of salidroside on focal cerebral
   ischemia/reperfusion injury involve the nuclear erythroid 2-related
   factor 2 pathway
SO NEURAL REGENERATION RESEARCH
LA English
DT Article
DE nerve regeneration; traditional Chinese medicine; salidroside; cerebral
   ischemia and reperfusion; nuclear factor erythroid 2-related factor 2;
   heme oxygenase-1; middle cerebral artery occlusion model; superoxide
   dismutase; neuroprotection; neural regeneration
ID OXIDATIVE STRESS; ARTERY OCCLUSION; MOUSE-BRAIN; NRF2; RATS; EXPRESSION;
   ISCHEMIA; MICE; HIPPOCAMPUS; ACTIVATOR
AB Salidroside, the main active ingredient extracted from Rhodiola crenulata, has been shown to be neuroprotective in ischemic cerebral injury, but the underlying mechanism for this neuroprotection is poorly understood. In the current study, the neuroprotective effect of salidroside on cerebral ischemia-induced oxidative stress and the role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was investigated in a rat model of middle cerebral artery occlusion. Salidroside (30 mg/kg) reduced infarct size, improved neurological function and histological changes, increased activity of superoxide dismutase and glutathione-S-transferase, and reduced malon-dialdehyde levels after cerebral ischemia and reperfusion. Furthermore, salidroside apparently increased Nrf2 and heme oxygenase-1 expression. These results suggest that salidroside exerts its neuroprotective effect against cerebral ischemia through anti-oxidant mechanisms and that activation of the Nrf2 pathway is involved. The Nrf2/antioxidant response element pathway may become a new therapeutic target for the treatment of ischemic stroke.
C1 [Han, Jing; Xiao, Qing; Lin, Yan-hua; Zheng, Zhen-zhu; He, Zhao-dong; Hu, Juan] Fujian Acad Tradit Chinese Med, Inst Mat Med, Fuzhou, Fujian, Peoples R China.
   [Hu, Juan; Chen, Li-dian] Fujian Univ Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Hu, J (corresponding author), Fujian Acad Tradit Chinese Med, Inst Mat Med, Fuzhou, Fujian, Peoples R China.
EM huj@fjtcm.edu.cn; lidianchen87@yahoo.com
RI Chen, Lidian/GSN-6461-2022
OI Chen, Lidian/0000-0002-8699-0839; Han, Jing/0000-0002-7142-1991
FU Independent Research Project of Fujian Academy of Traditional Chinese
   Medicine in China [2012fjzyyk-4]; Natural Science Foundation of Fujian
   Province in China [2014J01340]; Fujian Provincial Health and Family
   Planning Commission [2014-ZQN-JC-32]; Platform for Preclinical Studies
   of Traditional Chinese Medicine and Quality Control Engineering
   Technology Research Center of Fujian Province in China [2009Y2003]
FX This work was supported by the Independent Research Project of Fujian
   Academy of Traditional Chinese Medicine in China, No. 2012fjzyyk-4; the
   Natural Science Foundation of Fujian Province in China, No. 2014J01340;
   the Research Project of Fujian Provincial Health and Family Planning
   Commission, No. 2014-ZQN-JC-32; a grant from the Platform for
   Preclinical Studies of Traditional Chinese Medicine and Quality Control
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NR 31
TC 47
Z9 55
U1 1
U2 23
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 1673-5374
EI 1876-7958
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD DEC
PY 2015
VL 10
IS 12
BP 1989
EP 1996
DI 10.4103/1673-5374.172317
PG 8
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA DC0RU
UT WOS:000368926200028
PM 26889188
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ni, J
   Li, YM
   Xu, YW
   Guo, R
AF Ni, Jing
   Li, Yuanmin
   Xu, Yawei
   Guo, Rong
TI Salidroside protects against cardiomyocyte apoptosis and ventricular
   remodeling by AKT/HO-1 signaling pathways in a diabetic cardiomyopathy
   mouse model
SO PHYTOMEDICINE
LA English
DT Article
DE Diabetic cardiomyopathy; Salidroside; Cardiomyocytes; AKT signaling
   pathway; Heme oxygenase-1
AB Background: Diabetic cardiomyopathy is characterized by both systolic and diastolic dysfunction due to decreased contractility, as well as reduced compliance of the myocardium. Oxidative stress plays a significant role in diabetes mellitus and its cardiovascular complications. Salidroside, a glucoside of the phenylpropanoid tyrosol, reportedly increases the levels of the antioxidative enzymes, nuclear factor erythroid 2-related factor 2, and heme oxygenase-1 (HO-1) to counteract oxidative stress; however, the underlying mechanisms are poorly understood.
   Purpose: Here we investigate the potential cardio-protective effects of salidroside and its mechanism in a diabetic animal model.
   Methods: Male db/m, db/db, and age-matched wild-type mice were treated with salidroside at low dose (0.025 mg/kg) or high dose (0.05 mg/kg) by gavage every day for 12 weeks. Cardiac function and structure were assessed by echocardiography and histopathological examination. H9C2 cardiomyocytes were exposed in vitro to advanced glycosylation end products (400 mu g/ml) and treated with salidroside (0.1, 1, or 10 mu M). The expression of signaling-related genes were explored by western blotting and real-time PCR.
   Results: Salidroside treatment significantly improved diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis in vivo. Mechanistically, salidroside markedly up-regulates HO-1 expression by activation of the AKT signaling pathway.
   Conclusion: Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling in diabetic mice. This cardio-protective effect of salidroside is dependent on AKT signaling activation.
C1 [Ni, Jing; Xu, Yawei; Guo, Rong] Tongji Univ, Shanghai Peoples Hosp 10, Dept Cardiol, Sch Med, Shanghai 200072, Peoples R China.
   [Li, Yuanmin] Tongji Univ, Shanghai Peoples Hosp 10, Dept Cardiothorac Surg, Sch Med, Shanghai 200072, Peoples R China.
C3 Tongji University; Tongji University
RP Guo, R (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Dept Cardiol, Sch Med, Shanghai 200072, Peoples R China.
EM 09_doctorguo@tongji.edu.cn
OI Guo, Rong/0000-0003-1323-5450
FU National Natural Science Foundation of China [81700378]; Excellent Youth
   Scholars of Shanghai 10th People's hospital [2018-3636]
FX This work was supported by grants from the National Natural Science
   Foundation of China (grant no. 81700378) and the Excellent Youth
   Scholars of Shanghai 10th People's hospital (grant no. 2018-3636).
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TC 33
Z9 38
U1 4
U2 38
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD FEB
PY 2021
VL 82
AR 153406
DI 10.1016/j.phymed.2020.153406
EA JAN 2021
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA QJ7HS
UT WOS:000619858000001
PM 33422954
DA 2026-05-27
ER

PT J
AU Grech-Baran, M
   Syklowska-Baranek, K
   Giebultowicz, J
   Wroczynski, P
   Pietrosiuk, A
AF Grech-Baran, Marta
   Syklowska-Baranek, Katarzyna
   Giebultowicz, Joanna
   Wroczynski, Piotr
   Pietrosiuk, Agnieszka
TI TYROSOL GLUCOSYLTRANSFERASE ACTIVITY AND SALIDROSIDE PRODUCTION IN
   NATURAL AND TRANSFORMED ROOT CULTURES OF RHODIOLA KIRILOWII
   (REGEL) REGEL ET MAXIMOWICZ
SO ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA
LA English
DT Article
DE Rhodiola kirilowii; TGase; salidroside; transformed root culture;
   biotransformation
ID HAIRY ROOTS; GLYCOSYLTRANSFERASES; BIOTRANSFORMATION; BIOSYNTHESIS
AB The study examined tyrosol glucosyltransferase activity and the efficiency of salidroside production in natural and transformed root cultures of Rhodiola kirilowii (Regel) Regel et Maximowicz. Neither enzyme activity nor salidroside accumulation were detected in natural and transformed root cultures maintained in media without tyrosol. To induce TGase activity in biotransformation reactions, tyrosol was added to natural and transformed root cultures on the day of inoculation. The first peak of TGase activity (0.23 U/mu g) was detected on day 9 in natural root culture, accompanied by the highest salidroside content (15.79 mg/g d.w.), but TGase activity was highest (0.27 U/mu g) on day 15. In transformed root culture, day 18 showed the highest TGase activity (0.15 U/mu g), which coincided with the highest salidroside content (2.4 mg/g d.w.). Based on these results, tyrosol was added to the medium on the days of highest previously detected activity of TGase: day 15 for natural root cultures and day 18 for transformed root cultures. This strategy gave significantly higher yields of salidroside than in the cultures supplemented with tyrosol on the day of inoculation. In natural root culture, salidroside production reached 21.89 mg/g d.w., while precursor feeding in transformed root cultures caused a significant increase in salidroside accumulation to 7.55 mg/g d.w. In all treatments, salidroside production was lower in transformed than in natural root cultures.
C1 [Grech-Baran, Marta; Syklowska-Baranek, Katarzyna; Pietrosiuk, Agnieszka] Med Univ Warsaw, Dept Biol & Pharmaceut Bot, PL-02097 Warsaw, Poland.
   [Giebultowicz, Joanna; Wroczynski, Piotr] Med Univ Warsaw, Dept Bioanal & Drug Anal, PL-02097 Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw
RP Pietrosiuk, A (corresponding author), Med Univ Warsaw, Dept Biol & Pharmaceut Bot, Banacha 1, PL-02097 Warsaw, Poland.
EM agnieszka.pietrosiuk@wum.edu.pl
RI Sykłowska-Baranek, Katarzyna/U-4650-2018; Pietrosiuk,
   Agnieszka/A-1320-2012; Giebultowicz, Joanna/M-5956-2018
OI Sykłowska-Baranek, Katarzyna/0000-0002-9150-7872; Wroczyński,
   Piotr/0000-0001-7494-2154; Pietrosiuk, Agnieszka/0000-0001-7165-5336;
   Giebultowicz, Joanna/0000-0002-2567-4453
FU Medical University of Warsaw [FW21/PM31D/12]
FX We thank Dr. Anna Krajewska-Patan and Dr. Waldemar Buchwald (Institute
   of Natural Fibres and Medicinal Plants, Poznan, Poland) for kindly
   providing Rhodiola kirilowii (Regel) Regel et Maximowicz seeds. This
   study was supported by a research grant for young scientists from the
   Medical University of Warsaw (FW21/PM31D/12).
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U2 20
PU POLSKA AKAD NAUK, POLISH ACAD SCIENCES, PAS BRANCH CRACOW
PI WARSZAWA
PA PL DEFILAD 1, 00-901 WARSZAWA, POLAND
SN 0001-5296
EI 1898-0295
J9 ACTA BIOL CRACOV BOT
JI Acta Biol. Crac. Ser. Bot.
PY 2013
VL 55
IS 2
BP 126
EP 133
DI 10.2478/abcsb-2013-0025
PG 8
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA AB8YJ
UT WOS:000332075700014
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, SQ
   Chen, X
   Yang, YM
   Zhou, XY
   Liu, J
   Ding, F
AF Zhang, Shuqiang
   Chen, Xia
   Yang, Yumin
   Zhou, Xinyang
   Liu, Jie
   Ding, Fei
TI Neuroprotection against cobalt chloride-induced cell apoptosis of
   primary cultured cortical neurons by salidroside
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Salidroside; Cobalt chloride; Hypoxia; Cell apoptosis; Cortical neurons
ID FACTOR-KAPPA-B; HYPOXIA-INDUCIBLE FACTOR; ROSEA L. EXTRACT;
   RHODIOLA-ROSEA; PC12 CELLS; OXIDATIVE STRESS; ACTIVATION; TRANSCRIPTION;
   EXPRESSION; ISCHEMIA
AB Salidroside, a phenol glycoside of plant origin, has been documented to possess a broad spectrum of pharmacological properties, including protective effects against neuronal death induced by different insults. To provide further insights into the neuroprotective functions peculiar to salidroside, this study used primary cultured cortical neurons of rats as a cell model to examine whether salidroside was able to prevent against cell damage after exposure to cobalt chloride (CoCl2), a hypoxia-inducing agent. The data from 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, Hoechst33342 staining, terminal deoxynucleotidyl transferase dUTP-mediated nicked end labeling assay, and Bax/Bcl-2 ratio analysis indicated that salidroside pretreatment attenuated hypoxia-induced apoptotic cell death of primary cultured cortical neurons in a dose-dependent manner. Moreover, preliminary exploration of the possible mechanisms suggested that the protective effects of salidroside, shown in our experimental setting, might probably be mediated by enhancing the expression of hypoxia-inducible factor-1 alpha, alleviating the increase of intracellular reactive oxygen species levels, and inhibiting over-expression of nuclear factor-kappa B protein.
C1 [Zhang, Shuqiang; Chen, Xia; Yang, Yumin; Zhou, Xinyang; Liu, Jie; Ding, Fei] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University
RP Ding, F (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM shengdd@public.nt.js.cn
RI DING, FEI/KLD-8925-2024; yang, zhou/MFI-8086-2025
FU National Natural Science Foundation of China [30870881]; Jiangsu Higher
   Education Institutions; Jiangsu Education Department [08KJA310002]
FX This study was supported by the National Natural Science Foundation of
   China (Grant No. 30870881), a Project Funded by the Priority Academic
   Program Development of Jiangsu Higher Education Institutions, and the
   key project of Jiangsu Education Department (Grant No. 08KJA310002).
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VL 354
IS 1-2
BP 161
EP 170
DI 10.1007/s11010-011-0815-4
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 785GO
UT WOS:000292215600017
PM 21499890
DA 2026-05-27
ER

PT J
AU Li, Y
   Xue, WH
   Li, SY
   Cui, LL
   Gao, YX
   Li, LL
   Chen, R
   Zhang, X
   Xu, RH
   Jiang, W
   Zhang, XJ
   Wang, LN
AF Li, Ying
   Xue, Weihong
   Li, Songyi
   Cui, Lili
   Gao, Yuxiao
   Li, Linlin
   Chen, Rong
   Zhang, Xiao
   Xu, Renhao
   Jiang, Wei
   Zhang, Xiangjian
   Wang, Lina
TI Salidroside promotes angiogenesis after cerebral ischemia in mice
   through Shh signaling pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Ischemic stroke; Salidroside; Shh signaling pathway; Angiogenesis
ID REACTIVE ASTROCYTES; LONG-TERM; STROKE; RECOVERY; BRAIN; EXPRESSION;
   COMORBIDITIES; GROWTH
AB Aims: The purpose of this study was to explore the impacts of salidroside on vascular regeneration, vascular structural changes and long-term neurological recuperation following cerebral ischemia and its possible mechanism. Main methods: From Day 1 to Day 28, young male mice with middle cerebral artery blockage received daily doses of salidroside and measured neurological deficits. On the 7th day after stroke, the volume of cerebral infarction was determined using TTC and HE staining. Microvascular density, astrocyte coverage, angiogenesis and the expression of the Shh signaling pathway were detected by IF, qRT - PCR and WB at 7, 14 and 28 days after stroke. Changes in blood flow, blood vessel density and diameter from stroke to 28 days were measured by the LSCI and TPMI. Key findings: Compared with the dMACO group, the salidroside treatment group significantly promoted the recovery of neurological function. Salidroside was found to enhance cerebral blood flow perfusion and reduce the infarct on the 7th day after stroke. From the 7th to the 28th day after stroke, salidroside treatment boosted the expression of CD31, CD31 +/BrdU +, and GFAP in the cortex around the infarction site. On the 14th day after stroke, salidroside significantly enhanced the width and density of blood vessels. Salidroside increased the expression of histones and genes in the Shh signaling pathway during treatment, and this effect was weakened by the Shh inhibitor Cyclopamine. Significance: Salidroside can restore nerve function, improve cerebral blood flow, reduce cerebral infarction volume, increase microvessel density and promote angiogenesis via the Shh signaling pathway.
C1 [Xue, Weihong; Cui, Lili; Li, Linlin; Zhang, Xiao; Zhang, Xiangjian; Wang, Lina] Hebei Med Univ, Dept Neurol, Hosp 2, 215 Hepingxi Rd, Shijiazhuang 050000, Hebei, Peoples R China.
   [Li, Ying; Li, Songyi; Cui, Lili; Gao, Yuxiao; Li, Linlin; Chen, Rong; Xu, Renhao; Jiang, Wei; Zhang, Xiangjian; Wang, Lina] Hebei Collaborat Innovat Ctr Cardio Cerebrovasc Di, Shijiazhuang 050000, Hebei, Peoples R China.
   [Li, Ying; Li, Songyi; Cui, Lili; Gao, Yuxiao; Li, Linlin; Chen, Rong; Xu, Renhao; Jiang, Wei; Zhang, Xiangjian; Wang, Lina] Hebei Key Lab Vasc Homeostasis, Shijiazhuang 050000, Hebei, Peoples R China.
C3 Hebei Medical University
RP Zhang, XJ; Wang, LN (corresponding author), Hebei Med Univ, Dept Neurol, Hosp 2, 215 Hepingxi Rd, Shijiazhuang 050000, Hebei, Peoples R China.
EM zhang6xj@aliyun.com; dnsd4@163.com
RI wang, linan/JKI-1973-2023; li, song'yi/MAI-1079-2025; Gao,
   yuxiao/NFS-2705-2025
OI zhang, xiao/0009-0006-2459-866X; 
FU Hebei Key Laboratory of Vascular Homeostasis [82271366]; Health
   Commission of Hebei Province [20567630H];  [20190061]
FX This work was generously supported by grants from the National Natural
   Science Foundation of China (No. 81974184 and No.r 82271366) , Hebei Key
   Laboratory of Vascular Homeostasis (20567630H) and the Health Commission
   of Hebei Province (20190061) .
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NR 51
TC 16
Z9 18
U1 3
U2 18
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2024
VL 174
AR 116625
DI 10.1016/j.biopha.2024.116625
EA APR 2024
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA SC0M9
UT WOS:001232143100001
PM 38643543
OA gold
DA 2026-05-27
ER

PT J
AU Ye, MY
   Zhao, F
   Ma, K
   Zhou, K
   Ma, JX
   Fu, HY
   Xu, ZB
   Huang, WJ
   Wang, WZ
   Zhao, JF
   Lv, BD
AF Ye, Miaoyong
   Zhao, Fan
   Ma, Ke
   Zhou, Kang
   Ma, Jianxiong
   Fu, Huiying
   Xu, Zengbao
   Huang, Wenjie
   Wang, Wenzhi
   Zhao, Jianfeng
   Lv, Bodong
TI Enhanced effects of salidroside on erectile function and corpora
   cavernosa autophagy in a cavernous nerve injury rat model
SO ANDROLOGIA
LA English
DT Article
DE cavernous nerve injury; erectile dysfunction; radical prostatectomy;
   salidroside
ID ENDOTHELIAL DYSFUNCTION; RADICAL PROSTATECTOMY; FIBROSIS; PATHWAY;
   REHABILITATION; SILDENAFIL; PREVENTION; PROTECTS; THERAPY; CELLS
AB We explored the efficacy and mechanisms of salidroside treatment for erectile dysfunction induced by bilateral cavernous nerve injury (BCNI). Forty male rats were divided into four groups as follows: sham (cavernous nerves exposed only) (S); BCNI (M); BCNI + rapamycin (M + rapamycin); and BCNI + salidroside (M + salidroside). Erectile function in the rats was measured by intracavernosal pressure. Penile tissue was harvested for transmission electron microscopy, immunohistochemistry, immunofluorescence, Masson's trichrome staining, haematoxylin-eosin staining, TdT-mediated dUTP Nick End Labeling and western blotting. The M group exhibited a decrease in erectile responses and increased apoptosis and fibrosis compared to these in the S group. Meanwhile, nerve content and the penile atrophy index were also decreased in the M group. Treatment with salidroside and rapamycin for 3 weeks partially restored erectile function and significantly attenuated corporal apoptosis, fibrosis, nerve content and penile atrophy in the M group. Moreover, the autophagy level was further enhanced in the M + salidroside group, which was the same as that in the positive observation group (M + rapamycin). Salidroside treatment not only improved erectile function in rats with BCNI, but also inhibited apoptosis and fibrosis and ameliorated the loss of nerve content and endothelial and corpus cavernosum smooth muscle cells by promoting protective autophagy.
C1 [Ye, Miaoyong] Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Urol, Affiliated Wenling Hosp, Wenling, Peoples R China.
   [Ye, Miaoyong; Ma, Ke; Zhou, Kang; Ma, Jianxiong] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China.
   [Zhao, Fan] Nantong Univ, Dept Urol & Androl, Affiliated Hosp, Nantong, Peoples R China.
   [Fu, Huiying; Lv, Bodong] Zhejiang Chinese Med Univ, Res Inst Urol & Androl, Hangzhou, Peoples R China.
   [Xu, Zengbao] Huzhou Hosp Tradit Chinese Med, Dept Urol, Huzhou, Peoples R China.
   [Huang, Wenjie; Wang, Wenzhi; Zhao, Jianfeng; Lv, Bodong] Zhejiang Chinese Med Univ, Dept Urol & Androl, Affiliated Hosp 2, Hangzhou, Peoples R China.
   [Lv, Bodong] Key Lab Integrat Chinese & Western Med Prevent &, Hangzhou, Peoples R China.
C3 Wenzhou Medical University; Zhejiang Chinese Medical University; Nantong
   University; Zhejiang Chinese Medical University; Zhejiang Chinese
   Medical University
RP Lv, BD (corresponding author), Zhejiang Chinese Med Univ, Key Lab Integrat Chinese & Western Med Prevent &, Hangzhou 310053, Peoples R China.
EM bodonglv0571@163.com
RI Huang, Wenjie/AFS-0473-2022; fu, huiying/GZG-2399-2022
FU Natural Science Foundation of Zhejiang Province [LY19H270011,
   LY18H270002, LY18H05004, LQ19H040001, GF20H270004]; National Natural
   Science Foundation of China [81603620, 81804092, 82004360, 82074433]
FX Natural Science Foundation of Zhejiang Province, Grant/Award Number:
   LY19H270011, LY18H270002, LY18H05004, LQ19H040001 and GF20H270004;
   National Natural Science Foundation of China, Grant/Award Number:
   81603620, 81804092, 82004360 and 82074433
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NR 55
TC 11
Z9 15
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD JUL
PY 2021
VL 53
IS 6
AR e14044
DI 10.1111/and.14044
EA MAR 2021
PG 14
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SP9MF
UT WOS:000627557700001
PM 33709426
DA 2026-05-27
ER

PT J
AU Agbo, MO
   Odimegwu, DC
   Okoye, FBC
   Osadebe, PO
AF Agbo, Matthias Onyebuchi
   Odimegwu, Damian Chukwu
   Okoye, Festus Basden Chiedu
   Osadebe, Patience Ogoamaka
TI Antiviral activity of Salidroside from the leaves of Nigerian mistletoe
   (Loranthus micranthus Linn) parasitic on Hevea
   brasiliensis against respiratory syncytial virus
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE hRSV; Loranthus micranthus Linn; Salidroside; structure elucidation;
   anti-hRSV activity
ID IN-VITRO
AB Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi-preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside. The antiviral activity of the isolated compound was evaluated against the respiratory syncytial virus. The isolated Salidroside showed potent inhibition towards a recombinant straining respiratory syncytial virus with Inhibitory Concentration (IC50) value of 10.3 +/- 1.50 mu g/mL. The result indicates that Salidroside is an efficient antiviral agent against RSV infection and might be useful for the management of RSV pathogenesis.
C1 [Agbo, Matthias Onyebuchi] Heinrich Heine Univ, Inst Pharmaceut Biol & Biotechnol, Dusseldorf, Germany.
   [Agbo, Matthias Onyebuchi; Osadebe, Patience Ogoamaka] Univ Nigeria, Dept Pharmaceut & Med Chem, Nsukka, Nigeria.
   [Odimegwu, Damian Chukwu] Ruhr Univ Bochum, Dept Mol & Med Virol, Bochum, Germany.
   [Odimegwu, Damian Chukwu] Univ Nigeria, Dept Pharmaceut & Pharmaceut Microbiol, Nsukka, Nigeria.
   [Okoye, Festus Basden Chiedu] Nnamdi Azikiwe Univ, Dept Pharmaceut & Med Chem, Awka, Nigeria.
C3 Heinrich Heine University Dusseldorf; University of Nigeria; Ruhr
   University Bochum; University of Nigeria
RP Agbo, MO (corresponding author), Heinrich Heine Univ, Inst Pharmaceut Biol & Biotechnol, Dusseldorf, Germany.; Agbo, MO (corresponding author), Univ Nigeria, Dept Pharmaceut & Med Chem, Nsukka, Nigeria.
EM matthias.agbo@unn.edu.ng
RI Okoye, Festus/V-4841-2019; Okoye, Festus Basden Chiedu/V-4841-2019;
   Agbo, Matthias/F-7538-2019
OI Okoye, Festus/0000-0001-8414-2329; Odimegwu, Damian/0000-0001-6537-9160;
   Okoye, Festus Basden Chiedu/0000-0001-9661-5920; Agbo,
   Matthias/0000-0001-8210-306X
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NR 22
TC 7
Z9 11
U1 0
U2 7
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD JUL
PY 2017
VL 30
IS 4
BP 1251
EP 1256
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FD1OA
UT WOS:000407305400009
PM 29039322
DA 2026-05-27
ER

PT J
AU Zheng, KYZ
   Zhang, ZX
   Guo, AJY
   Bi, CWC
   Zhu, KY
   Xu, SL
   Zhan, JYX
   Lau, DTW
   Dong, TTX
   Choi, RCY
   Tsim, KWK
AF Zheng, Ken Yu-Zhong
   Zhang, Zhen-Xia
   Guo, Ava Jiang-Yang
   Bi, Cathy Wen-Chuang
   Zhu, Kevin Yue
   Xu, Sherry Li
   Zhan, Janis Ya-Xian
   Lau, David Tai-Wei
   Dong, Tina Ting-Xia
   Choi, Roy Chi-Yan
   Tsim, Karl Wah-Keung
TI Salidroside stimulates the accumulation of HIF-1α protein resulted in
   the induction of EPO expression: A signaling via blocking the
   degradation pathway in kidney and liver cells
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Hypoxia-inducible factor; Erythropoietin; Hypoxia
   responsive element
ID RADIX ANGELICAE SINENSIS; HYPOXIA-INDUCIBLE FACTOR; IN-VIVO;
   ERYTHROPOIETIN; ASTRAGALI; STRESS; HIF-2; GENE
AB Rhodiolae Crenulatae Radix et Rhizoma (Rhodiola), the root and rhizome of Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba, has been used as a traditional Chinese medicine (TCM) to increase the body resistance to mountain sickness in preventing hypoxia; however, the functional ingredient responsible for this adaptogenic effect has not been revealed. Here, we have identified salidroside, a glycoside predominantly found in Rhodiola, is the chemical in providing such anti-hypoxia effect. Cultured human embryonic kidney fibroblast (HEK293T) and human hepatocellular carcinoma (HepG2) were used to reveal the mechanism of this hematopoietic function mediated by salidroside. The application of salidroside in cultures induced the expression of erythropoietin (EPO) mRNA from its transcription regulatory element hypoxia response element (HRE), located on EPO gene. The application of salidroside stimulated the accumulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein, but not HIF-2 alpha protein: the salidroside-induced HIF-1 alpha protein was via the reduction of HIF-1a degradation but not the mRNA induction. The increased HIF-1 alpha could account for the activation of EPO gene. These results supported the notion that hematopoietic function of Rhodiola was triggered, at least partially, by salidroside. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Zheng, Ken Yu-Zhong; Guo, Ava Jiang-Yang; Bi, Cathy Wen-Chuang; Zhu, Kevin Yue; Xu, Sherry Li; Zhan, Janis Ya-Xian; Lau, David Tai-Wei; Dong, Tina Ting-Xia; Choi, Roy Chi-Yan; Tsim, Karl Wah-Keung] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China.
   [Zheng, Ken Yu-Zhong; Guo, Ava Jiang-Yang; Bi, Cathy Wen-Chuang; Zhu, Kevin Yue; Xu, Sherry Li; Zhan, Janis Ya-Xian; Lau, David Tai-Wei; Dong, Tina Ting-Xia; Choi, Roy Chi-Yan; Tsim, Karl Wah-Keung] Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China.
   [Zheng, Ken Yu-Zhong; Zhang, Zhen-Xia] Hanshan Normal Univ, Dept Biol, Chaozhou 521041, Guangdong, Peoples R China.
C3 Hong Kong University of Science & Technology; Hong Kong University of
   Science & Technology; Hanshan Normal University
RP Tsim, KWK (corresponding author), Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay Rd, Hong Kong, Hong Kong, Peoples R China.
EM botsim@ust.hk
OI Zheng, Yuzhong/0000-0001-7208-0642; Lau, Tai Wai
   David/0000-0002-3443-1808; Tsim, Karl/0000-0003-4808-1674
FU Research Grants Council of Hong Kong [HKUST 6419/06M, N_HKUST629/07,
   662608, 661110]; Croucher Foundation [CAS-CF07/08.SC03]
FX This research was supported by grants from Research Grants Council of
   Hong Kong (HKUST 6419/06M, N_HKUST629/07, 662608, 661110) and Croucher
   Foundation (CAS-CF07/08.SC03) to KWKT and DTWL.
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NR 30
TC 46
Z9 60
U1 1
U2 44
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAR 15
PY 2012
VL 679
IS 1-3
BP 34
EP 39
DI 10.1016/j.ejphar.2012.01.027
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 898HN
UT WOS:000300731900005
PM 22309741
DA 2026-05-27
ER

PT J
AU Gao, H
   Tian, KM
   Meng, YC
   Liu, XP
   Peng, YF
AF Gao, Hui
   Tian, Kunming
   Meng, Yichong
   Liu, Xueping
   Peng, Yingfu
TI Salidroside Ameliorates Cardiomyocyte Hypertrophy by Upregulating
   Peroxisome Proliferator-Activated Receptor-α
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE cardiac hypertrophy; salidroside; ATGL; PPAR alpha; energy metabolism
ID PPAR-ALPHA; LIPASE; INJURY; AMPK; DESNUTRIN/ATGL; STEATOSIS; LIPOLYSIS;
   PATHWAYS; PROTECTS; MICE
AB Cardiac hypertrophy is an adaptive change in response to pressure overload, however the hypertrophy may evolve toward heart failure if cannot be corrected as soon as possible. The dysfunction of peroxisome proliferator-activated receptor-alpha (PPAR alpha) plays a key role in cardiac hypertrophy. In the present study, salidroside inhibited the mRNA expressions of hypertrophic markers including atrial natriuretic factor and brain natriuretic peptide in a dosage-dependent manner. Furthermore, the protein expression and transcriptional activity of PPAR alpha were increased by salidroside in H9C2 cells treated with angiotensin II, as well as the target genes of PPAR alpha, while the situations were nearly reversed when PPAR alpha was knocked down. Next, salidroside could elevate the expression of ATGL, a key upstream regulator of PPAR alpha; the effects of salidroside including increasing PPAR alpha function and inhibiting cardiomyocyte hypertrophy were impaired by ATGL knockdown. Our present studies suggested that salidroside elevated PPAR alpha function to alleviate cardiomyocyte hypertrophy, which was involved in the increase of ATGL expression.
C1 [Gao, Hui; Meng, Yichong] Shaoxing Univ, Dept Pharmacol, Sch Med, Shaoxing, Peoples R China.
   [Gao, Hui; Peng, Yingfu] Jishou Univ, Sch Med, Dept Pharmacol, Jishou, Peoples R China.
   [Tian, Kunming] Zunyi Med Univ, Dept Environm Toxic, Zunyi, Guizhou, Peoples R China.
   [Liu, Xueping] Guangxi Univ Sci & Technol, Dept Pharmacol, Sch Med, Liuzhou, Peoples R China.
C3 Shaoxing University; Jishou University; Zunyi Medical University;
   Guangxi University of Science & Technology
RP Gao, H (corresponding author), Shaoxing Univ, Dept Pharmacol, Sch Med, Shaoxing, Peoples R China.; Gao, H; Peng, YF (corresponding author), Jishou Univ, Sch Med, Dept Pharmacol, Jishou, Peoples R China.; Liu, XP (corresponding author), Guangxi Univ Sci & Technol, Dept Pharmacol, Sch Med, Liuzhou, Peoples R China.
EM gaohui9512@163.com; 229836739@qq.com; pengyingfu@jsu.edu.cn
RI liu, xueping/MAH-6194-2025
FU National Natural Science Foundation of China [81760058, 81560059,
   81660042, 82160059]; Scientific Research Project of Health and Family
   Planning Commission of Hunan Province [C2017025]
FX Funding This work was supported by the National Natural Science
   Foundation of China (81760058, 81560059, 81660042 and 82160059), the
   Scientific Research Project of Health and Family Planning Commission of
   Hunan Province (C2017025).
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NR 35
TC 1
Z9 1
U1 0
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 11
PY 2022
VL 13
AR 865434
DI 10.3389/fphar.2022.865434
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1B0OS
UT WOS:000792145200001
PM 35479323
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hu, ZW
   Wang, ZM
   Liu, Y
   Wu, Y
   Han, XJ
   Zheng, J
   Yan, XF
   Wang, Y
AF Hu, Zhiwei
   Wang, Ziming
   Liu, Yong
   Wu, Yan
   Han, Xuejiao
   Zheng, Jian
   Yan, Xiufeng
   Wang, Yang
TI Metabolite Profile of Salidroside in Rats by Ultraperformance Liquid
   Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry
   and High-Performance Liquid Chromatography Coupled with
   Quadrupole-Linear Ion Trap Mass Spectrometry
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE salidroside; UPLC/Q-TOP-MS; HPLC/Q-trap-MS; metabolites; metabolic
   pathways
ID OLIVE OIL PHENOLS; RHODIOLA-ROSEA L.; IN-VITRO; PLASMA; IDENTIFICATION;
   TYROSOL
AB In the present work, the salidroside metabolite profile in rat urine was investigated, and subsequently the metabolic pathways of salidroside were proposed. After administrations of salidroside at an oral dose of 100 or 500 mg/kg, rat urine samples were collected and pretreated with methanol to precipitate the proteins. The pretreated samples were analyzed by an Acquity ultraperformance liquid chromatography (UPLC) coupled with an HSS T3 column and detected by quadrupole time-of-flight mass spectrometry (Q-TOF-MS) or high-performance liquid chromatography coupled with hybrid triple-quadrupole linear ion trap mass spectrometry (HPLC/Q-trap-MS). A total of eight metabolites were detected and identified on the basis of the characteristics of their protonated ions in the urine samples. The results elucidated that salidroside was metabolized via glucuronidation, sulfation, deglycosylation, hydroxylation, methylation, and dehydroxylation pathways in vivo.
C1 [Hu, Zhiwei; Wang, Ziming; Liu, Yong; Han, Xuejiao; Zheng, Jian; Yan, Xiufeng; Wang, Yang] Northeast Forestry Univ, Alkali Soil Nat Environm Sci Ctr, Harbin 150040, Peoples R China.
   [Hu, Zhiwei; Wang, Ziming; Liu, Yong; Han, Xuejiao; Zheng, Jian; Yan, Xiufeng; Wang, Yang] Minist Educ, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Harbin 150040, Peoples R China.
   [Liu, Yong; Wu, Yan] Heilongjiang Entry Exit Inspect & Quarantine Bur, Harbin 150001, Peoples R China.
C3 Northeast Forestry University - China
RP Wang, Y (corresponding author), Northeast Forestry Univ, Alkali Soil Nat Environm Sci Ctr, Harbin 150040, Peoples R China.
EM ywang1971@hotmail.com
OI Yan, Xiufeng/0000-0001-5127-494X
FU Fundamental Research Funds for the Central Universities [DL13EA02];
   Heilongjiang Provincial Natural Science Foundation of China [C201139]
FX This research was financially supported by the Fundamental Research
   Funds for the Central Universities (DL13EA02) and Heilongjiang
   Provincial Natural Science Foundation of China (C201139).
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NR 26
TC 21
Z9 27
U1 0
U2 60
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 21
PY 2015
VL 63
IS 41
BP 8999
EP 9005
DI 10.1021/acs.jafc.5b04510
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA CU3QA
UT WOS:000363438700004
PM 26461036
DA 2026-05-27
ER

PT J
AU Liao, ZL
   Su, H
   Tan, YF
   Qiu, YJ
   Zhu, JP
   Chen, Y
   Lin, SS
   Wu, MH
   Mao, YP
   Hu, JJ
   Yu, EY
AF Liao, Zheng-Luan
   Su, Heng
   Tan, Yun-Fei
   Qiu, Ya-Ju
   Zhu, Jun-Peng
   Chen, Yan
   Lin, Si-Si
   Wu, Ming-Hao
   Mao, Yan-Ping
   Hu, Jiao-Jiao
   Yu, En-Yan
TI Salidroside protects PC-12 cells against amyloid β-induced apoptosis by
   activation of the ERK1/2 and AKT signaling pathways
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE Alzheimer's disease; salidroside; apoptosis; extracellular signal
   regulated kinase 1/2; protein kinase B
ID ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; OXIDATIVE STRESS; RHODIOLA-ROSEA;
   A-BETA; MITOCHONDRIA; EXTRACTS; DEFICITS; PEPTIDE; BIOLOGY
AB Alzheimer's disease (AD) is one of the most frequent diseases in elderly people and causes high mortality. Its incidence is increasing annually and no effective therapeutic treatment currently exists. In the present study, salidroside, a major active ingredient of Rhodiola rosea, was able to protect PC-12 cells from the toxicity and apoptosis induced by AD inducer amyloid (A)beta(1--42). Salidroside significantly protected PC-12 cells by inhibiting A beta(1-42)-induced cytotoxicity and mitochondria-mediated endogenous caspase apoptotic pathways. Mechanistic studies demonstrated that salidroside significantly activated the extracellular signal regulated kinase (ERK)1/2 and protein kinase B (AKT) signaling pathways. This observation was further confirmed using the ERK1/2 inhibitor PD98059 and the AKT inhibitor LY294002, which demonstrated that salidroside promoted PC-12 cell survival and proliferation by activating the ERK1/2 and AKT signaling pathways. Salidroside is a therapeutic candidate for the treatment of AD and provides a basis for further drug development.
C1 [Liao, Zheng-Luan; Su, Heng; Tan, Yun-Fei; Qiu, Ya-Ju; Zhu, Jun-Peng; Chen, Yan; Yu, En-Yan] Zhejiang Prov Peoples Hosp, Dept Psychiat, 158 Shang Tang Rd, Hangzhou 310014, Zhejiang, Peoples R China.
   [Liao, Zheng-Luan; Su, Heng; Tan, Yun-Fei; Qiu, Ya-Ju; Zhu, Jun-Peng; Chen, Yan; Yu, En-Yan] Hangzhou Med Coll, Peoples Hosp, Psychiat & Mental Hlth, Hangzhou 310014, Zhejiang, Peoples R China.
   [Lin, Si-Si; Mao, Yan-Ping] Zhejiang Chinese Med Univ, Psychiat & Mental Hlth, Hangzhou 310053, Zhejiang, Peoples R China.
   [Wu, Ming-Hao; Hu, Jiao-Jiao] Bengbu Med Coll, Psychiat & Mental Hlth, Bengbu 233030, Anhui, Peoples R China.
   [Yu, En-Yan] Zhejiang Canc Hosp, Clin Psychol, Hangzhou 310022, Zhejiang, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Chinese Medical University; Bengbu
   Medical University; Zhejiang Cancer Hospital
RP Yu, EY (corresponding author), Zhejiang Prov Peoples Hosp, Dept Psychiat, 158 Shang Tang Rd, Hangzhou 310014, Zhejiang, Peoples R China.
EM yuenyan@aliyun.com
RI ; /G-1924-2016; Lin, SiSi/LTE-9620-2024
OI Zhu, Junpeng/0000-0001-9170-9397; 
FU Natural Science Foundation of China [81771158]; Science Foundation from
   Health Commission of Zhejiang Province [ZKJ-ZJ-1503, 2018278601,
   2019321345]
FX The present study was supported by the Natural Science Foundation of
   China (grant no. 81771158), Science Foundation from Health Commission of
   Zhejiang Province (grant no. ZKJ-ZJ-1503, 2018278601 and 2019321345).
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NR 37
TC 42
Z9 46
U1 1
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD APR
PY 2019
VL 43
IS 4
BP 1769
EP 1777
DI 10.3892/ijmm.2019.4088
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HO7EO
UT WOS:000461099500019
PM 30720058
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Li, XH
   Chen, FL
   Shen, HL
AF Li, Xiao-hua
   Chen, Fu-ling
   Shen, Hong-lin
TI Salidroside promoted osteogenic differentiation of adipose-derived
   stromal cells through Wnt/β-catenin signaling pathway
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Salidroside; Adipose-derived stromal cells; Wnt; beta-catenin signaling
   pathway; Osteogenic differentiation
ID SENESCENCE
AB BackgroundBone disease causes short-term or long-term physical pain and disability. It is necessary to explore new drug for bone-related disease. This study aimed to explore the role and mechanism of Salidroside in promoting osteogenic differentiation of adipose-derived stromal cells (ADSCs).MethodsADSCs were isolated and treated with different dose of Salidroside. Cell count kit-8 (CCK-8) assay was performed to assess the cell viability of ADSCs. Then, ALP and ARS staining were conducted to assess the early and late osteogenic capacity of ADSCs, respectively.Then, differentially expressed genes were obtained by R software. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the differentially expressed genes were further analyzed. The expression of OCN, COL1A1, RUNX2, WNT3A, and beta -catenin were measured by real-time PCR and Western blot analysis. Last, beta -catenin was silenced by small interfering RNA.ResultsSalidroside significantly increased the ADSCs viability at a dose-response manner. Moreover, Salidroside enhanced osteogenic capacity of ADSCs, which are identified by enhanced ALP activity and calcium deposition. A total of 543 differentially expressed genes were identified between normal and Salidroside-treated ADSCs. Among these differentially expressed genes, 345 genes were upregulated and 198 genes were downregulated. Differentially expressed genes enriched in the Wnt/beta -catenin signaling pathway. Western blot assay indicated that Salidroside enhanced the WNT3A and beta -catenin expression. Silencing beta -catenin partially reversed the promotion effects of Salidroside. PCR and Western blot results further confirmed these results.ConclusionSalidroside promoted osteogenic differentiation of ADSCs through Wnt/beta -catenin signaling pathway.
C1 [Li, Xiao-hua] Peoples Hosp Changshou, Dept Pharm, Chongqing, Peoples R China.
   [Chen, Fu-ling] Peoples Hosp Hechuan, Dept Orthopaed, Chongqing, Peoples R China.
   [Shen, Hong-lin] Peoples Hosp Changshou, Dept Joint Trauma Surg, 16 Beiguan,Fengcheng St, Chongqing, Peoples R China.
RP Shen, HL (corresponding author), Peoples Hosp Changshou, Dept Joint Trauma Surg, 16 Beiguan,Fengcheng St, Chongqing, Peoples R China.
EM shejujian19950618@163.com
CR Anastasilakis AD, 2021, OSTEOPOROSIS INT, V32, P2377, DOI 10.1007/s00198-021-06002-5
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NR 27
TC 11
Z9 12
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JUL 16
PY 2021
VL 16
IS 1
AR 456
DI 10.1186/s13018-021-02598-w
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA TM0IW
UT WOS:000675239800002
PM 34271966
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, FL
   Tang, H
   Xiao, FR
   Gong, JL
   Peng, Y
   Meng, XL
AF Li, Fenglin
   Tang, Hong
   Xiao, Furen
   Gong, Jingli
   Peng, Yong
   Meng, Xiangle
TI Protective Effect of Salidroside from Rhodiolae Radix on
   Diabetes-Induced Oxidative Stress in Mice
SO MOLECULES
LA English
DT Article
DE oxidative stress; diabetes mellitus; salidroside; hypoglycemic; mice
ID METABOLIC SYNDROME; IN-VITRO; EXTRACT; SACHALINENSIS; THERAPY; ACID
AB It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.
C1 [Li, Fenglin; Xiao, Furen] Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
   [Li, Fenglin; Gong, Jingli] Jilin Agr Sci & Technol Coll, Dept Bioengn, Jilin 132101, Peoples R China.
   [Tang, Hong] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Endocrinol, Shanghai 200032, Peoples R China.
   [Peng, Yong] Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 066004, Peoples R China.
   [Meng, Xiangle] Henan Coll Tradit Chinese Med, Dept Pharm, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China.
C3 Yanshan University; Jilin Agricultural Science & Technology University;
   Shanghai University of Traditional Chinese Medicine; Yanshan University;
   Henan University of Traditional Chinese Medicine
RP Xiao, FR (corresponding author), Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
EM swgclfl@163.com; lhhong_tang@qq.com; swgclifenglin@sina.com;
   591142473@qq.com; py81ysu@126.com; mxiangle@yahoo.cn
RI Li, Fenglin/NYS-8823-2025
OI Xiao, Furen/0000-0002-3076-2730
FU Natural Sciences Foundation of Jilin Province [20090905]; Natural
   Science Foundation for Young Scientists of Jilin Agricultural Science
   and Technology College [2010124]; National Health and Medical Research
   Council (NHMRC) [2010124] Funding Source: National Health and Medical
   Research Council (NHMRC)
FX This work was supported by the Natural Sciences Foundation of Jilin
   Province (Grant No. 20090905) and Natural Science Foundation for Young
   Scientists of Jilin Agricultural Science and Technology College (Grant
   No. 2010124).
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NR 55
TC 77
Z9 93
U1 0
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2011
VL 16
IS 12
BP 9912
EP 9924
DI 10.3390/molecules16129912
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 866UQ
UT WOS:000298411200011
PM 22134398
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, AQ
   Ju, XL
AF Sun, An-Qi
   Ju, Xiu-Lian
TI Inhibitory effects of salidroside on MCF-7 breast cancer cells in
   vivo
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Salidroside; breast cancer; antitumor; apoptosis; xenograft; nude mice;
   MCF-7 cells
AB Objective
   We investigated the antitumor effects of salidroside and preliminarily examined its underlying mechanisms by establishing a nude mouse model bearing MCF-7 breast cancer cell xenografts.
   Methods
   The mice were grouped and intraperitoneally injected with salidroside, paclitaxel, or physiological saline. Tumor samples were weighed, and immunohistochemical staining with hematoxylin and eosin and anti-CD34 antibody was performed. Tumor cell apoptosis was observed using the terminal deoxynucleotidyl transferase deoxyuridine dUTP nick end labeling assay. Bcl-1, p53, Bax, and caspase 3 expression in tumor tissues was determined via western blotting.
   Results
   The tumor inhibition rate of high-dose salidroside was 75.16%, which was significantly higher than the rates for paclitaxel and saline. A tumor tissue pathology analysis revealed that high-dose salidroside inhibited tumor cell proliferation and promoted tumor cell apoptosis. Western blotting revealed that Bcl-2 and p53 expression were significantly lower in the salidroside group than in the other groups, whereas Bax and caspase 3 (17 kDa) expression were increased.
   Conclusions
   Salidroside was more effective than paclitaxel in inhibiting tumor growth in MCF-7 breast cancer cell-bearing nude mice. The mechanism of action may involve Bcl-2 and p53 downregulation and Bax and caspase 3 upregulation, thereby increasing proapoptotic factor expression and inducing tumor cell apoptosis.
C1 [Sun, An-Qi; Ju, Xiu-Lian] Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, 366 Huquan St, Wuhan 430073, Peoples R China.
   [Sun, An-Qi] Wuhan Inst Technol, Coll Post & Telecommun, Wuhan, Peoples R China.
C3 Wuhan Institute of Technology; Wuhan Institute of Technology
RP Ju, XL (corresponding author), Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, 366 Huquan St, Wuhan 430073, Peoples R China.
EM xiulianju2001@yahoo.com
OI , An-qi/0000-0002-7050-2423
FU Research Project of Hubei Provincial Department of Education [B2018429]
FX This study was supported by the Research Project of Hubei Provincial
   Department of Education (No. B2018429).
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NR 16
TC 12
Z9 14
U1 0
U2 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD NOV
PY 2020
VL 48
IS 11
AR 0300060520968353
DI 10.1177/0300060520968353
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PA6EB
UT WOS:000595725300001
PM 33238796
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, HS
   Ma, LQ
   Zhang, JX
   Shi, GL
   Hu, YH
   Wang, YN
AF Yu, Han-Song
   Ma, Lan-Qing
   Zhang, Ji-Xing
   Shi, Guang-Lu
   Hu, Yao-Hui
   Wang, You-Nian
TI Characterization of glycosyltransferases responsible for salidroside
   biosynthesis in Rhodiola sachalinensis
SO PHYTOCHEMISTRY
LA English
DT Article
DE Rhodiola sachalinensis; Crassulaceae; Secondary metabolism; Hairy root;
   Salidroside; UDP-glycosyltransferase
ID SALICYLIC-ACID; MOLECULAR-CLONING; SUBSTRATE-SPECIFICITY;
   GLUCOSYLTRANSFERASE; EXPRESSION; OVEREXPRESSION; CURCUMIN; CULTURES;
   FAMILY; CELLS
AB Salidroside, the 8-O-beta-D-glucoside of tyrosol, is a novel adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis A. Bor. Due to the scarcity of R. sachalinensis and its low yield of salidroside, there is great interest in enhancing production of salidroside by biotechnological manipulations. In this study, two putative UDP-glycosyltransferase (UGT) cDNAs, UGT72B14 and UGT74R1, were isolated from roots and cultured cells of methyl jasmonate (MeJA)-treated R. sachalinensis, respectively. The level of sequence identity between their deduced amino acid sequences was ca. 20%. RNA gel-blot analysis established that UGT72B14 transcripts were more abundant in roots, and UGT74R1 was highly expressed in the calli, but not in roots. Functional analysis indicated that recombinant UGT72B14 had the highest level of activity for salidroside production, and that the catalytic efficiency (V-max/K-m) of UGT72B14 was 620% higher than that of UGT74R1. The salidroside contents of the UGT72B14 and UGT74R1 transgenic hairy root lines of R. sachalinensis were also similar to 420% and similar to 50% higher than the controls, respectively. UGT72B14 transcripts were mainly detected in roots, and UGT72B14 had the highest level of activity for salidroside production in vitro and in vivo. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Yu, Han-Song; Hu, Yao-Hui] Jilin Agr Univ, Food Sci & Engn Coll, Changchun 130118, Peoples R China.
   [Ma, Lan-Qing; Shi, Guang-Lu; Wang, You-Nian] Beijing Agr Univ, Minist Agr PR China, Key Lab Urban Agr N, Beijing 102206, Peoples R China.
   [Zhang, Ji-Xing] Inner Mongolia Univ Nationalities, Coll Life Sci, Tongliao 028043, Peoples R China.
C3 Jilin Agricultural University; Beijing University of Agriculture; Inner
   Mongolia Minzu University
RP Hu, YH (corresponding author), Jilin Agr Univ, Food Sci & Engn Coll, Changchun 130118, Peoples R China.
EM yuhansong@jluhp.edu.cn; lqma@bac.edu.cn
RI guanglu, Shi/JRY-5435-2023
OI Yu, Hansong/0000-0002-7207-4936
FU National Natural Science Foundation of China [30872029, 30900112]; Key
   Natural Science Foundation of Beijing Municipality [5111001]; Foundation
   of Beijing Municipal Education Committee [KM201110020001]; Jurisdiction
   of Beijing Municipality [PHR20090516, PHR201108279]
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 30872029 and 30900112) and Key Natural Science Foundation of
   Beijing Municipality (No. 5111001), Foundation of Beijing Municipal
   Education Committee (No. KM201110020001), and Funding Project for
   Academic Human Resources Development in Institutions of Higher Learning
   Under the Jurisdiction of Beijing Municipality (No. PHR20090516 and
   PHR201108279).
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NR 34
TC 53
Z9 66
U1 8
U2 124
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD JUN
PY 2011
VL 72
IS 9
BP 862
EP 870
DI 10.1016/j.phytochem.2011.03.020
PG 9
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 774IB
UT WOS:000291377800004
PM 21497865
DA 2026-05-27
ER

PT J
AU Luo, F
   Liu, JY
   Yan, TH
   Miao, MX
AF Luo, Fen
   Liu Jingyan
   Yan, Tianhua
   Miao Mingxing
TI RETRACTED: Salidroside alleviates cigarette smoke-induced COPD in mice
   (Retracted article. See vol. 160, 2023)
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article; Retracted Publication
DE Salidroside; COPD; Inflammation
ID ACUTE LUNG INJURY; ISCHEMIA-REPERFUSION INJURY; IN-VIVO; SYNTHETIC
   SALIDROSIDE; MOUSE MODEL; TNF-ALPHA; INFLAMMATION; APOPTOSIS; PATHWAY;
   RATS
AB The present study was to evaluate the effects of salidroside (Sal) on CS (cigarette smoke)-induced COPD in mice and explore its underlying mechanisms. 50 male ICR mice were randomly assigned to five groups: control group, CS group, CS + dexamethasone (2 mg/kg) group, CS + salidroside (20 mg/kg) group and CS + salidroside (40 mg/kg) group. The COPD mice were induced by CS exposure for 8 weeks. The results of H&E staining demonstrated that Sal alleviated CS-induced pathological injury in lungs. Besides, Sal increased the activities of superoxide dismutase (SOD), reduced the content of malondialdehyde (MDA) in serum. Sal also inhibited the generations of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) in serum and lungs. Furthermore, the administration of Sal significantly inhibited the protein levels of MAPK/NF-kappa B pathway in CS-induced mice. Our findings showed that Sal might effectively ameliorate the progression of COPD via MAPK/NF-kappa B pathway. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Luo, Fen; Liu Jingyan; Yan, Tianhua; Miao Mingxing] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Yan, TH; Miao, MX (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
EM yantianhuabest@126.com; miaomingxingcpu@126.com
RI Su, Tianyuan/Y-7054-2019
FU National twelve five major drug discovery project [2011ZX09102-002-01]
FX This work was supported by National twelve five major drug discovery
   project (2011ZX09102-002-01).
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NR 41
TC 36
Z9 43
U1 0
U2 41
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2017
VL 86
BP 155
EP 161
DI 10.1016/j.biopha.2016.12.032
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7WU
UT WOS:000395523800022
PM 27978494
DA 2026-05-27
ER

PT J
AU Zhou, LP
   Yao, PP
   Jiang, LX
   Wang, ZY
   Ma, XH
   Wen, GX
   Yang, JT
   Zhou, BJ
   Yu, Q
AF Zhou, Liping
   Yao, Panpan
   Jiang, Lixia
   Wang, Zhaoyun
   Ma, Xiaohe
   Wen, Guangxin
   Yang, Jintao
   Zhou, Binjie
   Yu, Qin
TI Salidroside-pretreated mesenchymal stem cells contribute to
   neuroprotection in cerebral ischemic injury in vitro and in vivo
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE Mesenchymal stem cells; Salidroside; Cerebral ischemic injury; Cell
   survival; Neuroprotection
ID RAT MODEL; THERAPY; DIFFERENTIATE
AB Mesenchymal stem cells (MSCs) are considered a promising tool for treating cerebral ischemic injury. However, their poor survival after transplantation limits their therapeutic effect and applications. Salidroside has been reported to exert potent cytoprotective and neuroprotective effects. This study aimed to investigate whether salidroside could improve MSC survival under hypoxic-ischemic conditions and, subsequently, alleviate cerebral ischemic injury in a rat model. MSCs were pretreated by salidroside under hypoxic-ischemic conditions. The cell proliferation, migratory capacity, and apoptosis were evaluated by means of Cell Counting Kit-8, transwell assay, and flow cytometry. MSCs pretreated with salidroside were transplanted into the rats subsequent to middle cerebral artery occlusion. The grip strength, 2,3,5-triphenyltetrazolium chloride, and hematoxylin-eosin staining were used to analyze the therapeutic efficiency and pathological changes. The mature neuron marker NeuN and astrocyte marker GFAP in the focal area were detected by immunofluorescence. These results indicated that salidroside promoted the proliferation, migration and reduced apoptosis of MSCs under hypoxic-ischemic conditions. In vivo experiments revealed that transplantation of salidroside-pretreated MSCs strengthened the therapeutic efficiency by enhancing neurogenesis and inhibiting neuroinflammation in the hippocampal CA1 area after ischemia. Our results suggest that pretreatment with salidroside could be an effective strategy to enhance the cell survival rate and the therapeutic effect of MSCs in treating cerebral ischemic injury.
C1 [Zhou, Liping; Yao, Panpan; Jiang, Lixia; Wang, Zhaoyun; Ma, Xiaohe; Wen, Guangxin; Yang, Jintao; Zhou, Binjie; Yu, Qin] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University
RP Yu, Q (corresponding author), Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Zhejiang, Peoples R China.
EM qinyu3587@126.com
RI 杨, 晋涛/IUQ-4172-2023
FU National Natural Science Foundation of China [31570994]; Project of
   Zhejiang Education Department [Y20163679]
FX This work was financially supported by the National Natural Science
   Foundation of China (31570994); Project of Zhejiang Education Department
   (Y20163679).
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NR 38
TC 14
Z9 17
U1 0
U2 17
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD DEC
PY 2021
VL 52
IS 6
BP 1145
EP 1154
DI 10.1007/s10735-021-10022-0
EA SEP 2021
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA XD3TS
UT WOS:000700986400001
PM 34570327
DA 2026-05-27
ER

PT J
AU Feng, J
   Chen, K
   Xia, YJ
   Wu, LW
   Li, JJ
   Li, SN
   Wang, WW
   Lu, XY
   Liu, T
   Guo, CY
AF Feng, Jiao
   Chen, Kan
   Xia, Yujing
   Wu, Liwei
   Li, Jingjing
   Li, Sainan
   Wang, Wenwen
   Lu, Xiya
   Liu, Tong
   Guo, Chuanyong
TI Salidroside ameliorates autophagy and activation of hepatic stellate
   cells in mice via NF-κB and TGF-β1/Smad3 pathways
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE liver fibrosis; salidroside; hepatic stellate cells; autophagy; TGF-beta
   1/Smad3
ID LIVER FIBROSIS; TGF-BETA; EXTRACELLULAR-MATRIX; INJURY; MECHANISMS;
   PATHOGENESIS; PRETREATMENT; INHIBITION; EXPRESSION; APOPTOSIS
AB Purpose: Liver fibrosis is commonly seen and a necessary stage in chronic liver disease. The aim of this study was to explore the effect of salidroside on liver fibrosis in mice and its potential mechanisms.
   Materials and methods: Two mouse liver fibrosis models were established by intraperitoneal injection of carbon tetrachloride (CCl4) for 8 weeks and bile duct ligation for 14 days. Salidroside was injected intraperitoneally at doses of 10 and 20 mg/kg once a day. Gene and protein expression levels were determined by quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, Western blot, immunohistochemistry, and immunofluorescence.
   Results: Salidroside inhibited the production of extracellular matrix (ECM) and regulated the balance between MMP2 and TIMP1 and, therefore, alleviated liver fibrosis in the two fibrosis models. Salidroside reduced the production of transforming growth factor (TGF)-beta 1 in Kupffer cells and hepatic stellate cells (HSCs) via the nuclear factor-kappa B signaling pathway and, therefore, inhibited the activation of HSCs and autophagy by downregulation of the TGF-beta 1/Smad3 signaling pathway.
   Conclusion: Salidroside can effectively attenuate liver fibrosis by inhibiting the activation of HSCs in mice.
C1 [Feng, Jiao; Chen, Kan; Xia, Yujing; Wu, Liwei; Li, Jingjing; Li, Sainan; Wang, Wenwen; Lu, Xiya; Liu, Tong; Guo, Chuanyong] Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastroenterol, Sch Med, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.
C3 Tongji University
RP Guo, CY (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastroenterol, Sch Med, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.
EM guochuanyong@hotmail.com
RI ; Feng, Jiao/AFS-6380-2022
OI Guo, Chuanyong/0000-0002-6527-4673; Li, Sainan/0000-0002-1880-6294;
   Feng, Jiao/0000-0001-5344-7242; , Liwei/0000-0003-0322-722X
FU National Natural Science Foundation of China [81670472, 81700502,
   81500466]
FX This work was supported by the National Natural Science Foundation of
   China (grant numbers 81670472, 81700502, and 81500466).
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NR 54
TC 68
Z9 86
U1 1
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2018
VL 12
BP 1837
EP 1853
DI 10.2147/DDDT.S162950
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GK3EE
UT WOS:000436023300003
PM 29970958
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lai, WF
   Xie, XL
   Zhang, XQ
   Wang, YZ
   Chu, KD
   Brown, J
   Chen, LD
   Hong, GZ
AF Lai, Wenfang
   Xie, XiuLi
   Zhang, Xiaoqin
   Wang, Yingzheng
   Chu, Kedan
   Brown, John
   Chen, Lidian
   Hong, Guizhu
TI Inhibition of Complement Drives Increase in Early Growth Response
   Proteins and Neuroprotection Mediated by Salidroside After Cerebral
   Ischemia
SO INFLAMMATION
LA English
DT Article
DE Brain ischemia; Complement; Neuroprotection; Salidroside
ID MANNOSE-BINDING LECTIN; IMMEDIATE-EARLY GENES; PEROXIDE-INDUCED INJURY;
   ARTERY OCCLUSION; REPERFUSION INJURY; GLOBAL-ISCHEMIA; BRAIN ISCHEMIA;
   MESSENGER-RNA; EXPRESSION; INFLAMMATION
AB Salidroside is neuroprotective across a wide therapeutic time-window after cerebral ischemia-reperfusion injury (IRI). Here, we investigated the role of complement in mediating effects of salidroside after cerebral IRI in rats. Rats were administrated with vehicle or salidroside 50 mg/kg, given daily for either 24 or 48 h, after middle cerebral artery occlusion (MCAO) for 2 h and reperfusion for 1 h. Levels of proteins in ischemic brain were measured by immunofluorescence and western blotting. We observed early increases in the deposition of immunoglobulin M, mannose-binding lectin 2, and annexin IV on cerebral endothelial cells, induction of the complement components C3 and C3a, by 24 h after IRI, and a later significant increase in the complement component C1q by 48 h. Salidroside prevented these changes. The neuroplasticity-related early growth response proteins Egr1, Egr2, and Egr4 and activity-regulated cytoskeleton-associated protein increased transiently in the first 6 h after IRI but then decreased below baseline by 48 h after IRI. Neither salidroside nor a C3a receptor antagonist (C3aRA) affected these proteins 24 h after IRI, but both reversed their later decreases to similar and non-additive extents. Salidroside and C3aRA increased NeuN in a non-additive manner after IRI. Our results suggest that salidroside exerts neuroprotection by reducing early activation of the lectin pathway on the cerebral endothelium and inhibiting the gradual activation of the classical pathway after cerebral IRI. This prolonged neuroprotection may depend, at least in part, on increased expression of neuroplasticity-related genes driven by reduced complement activation.
C1 [Lai, Wenfang; Xie, XiuLi; Zhang, Xiaoqin; Wang, Yingzheng; Chu, Kedan; Brown, John; Chen, Lidian; Hong, Guizhu] Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Hong, GZ (corresponding author), Fujian Univ Tradit Chinese Med, Ctr Biomed Res & Dev, 1 Huatou Rd, Fuzhou, Fujian, Peoples R China.
EM guizhuhong@fjtcm.edu.cn
RI ; Chen, Lidian/GSN-6461-2022
OI Hong, Guizhu/0000-0003-3932-4777; Chen, Lidian/0000-0002-8699-0839
FU National Natural Science Foundation of China [81473382, 81603323];
   Department of Technology and Science of Fujian Province [2014Y4004,
   2015J01328, 2015J01685]; Collaborative Innovation Center for
   Rehabilitation Technology of Fujian University of Traditional Chinese
   Medicine (TCM); Rehabilitation Research of State Administration of TCM
FX This work was supported by the National Natural Science Foundation of
   China (Projects 81473382 and 81603323), the Department of Technology and
   Science of Fujian Province (Projects 2014Y4004, 2015J01328, and
   2015J01685), the Collaborative Innovation Center for Rehabilitation
   Technology of Fujian University of Traditional Chinese Medicine (TCM),
   and the Rehabilitation Research of State Administration of TCM.
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NR 48
TC 28
Z9 38
U1 1
U2 26
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD MAR
PY 2018
VL 41
IS 2
BP 449
EP 463
DI 10.1007/s10753-017-0701-7
PG 15
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA GA8AR
UT WOS:000428561000010
PM 29198014
DA 2026-05-27
ER

PT J
AU Yang, J
   Xia, YY
   Shen, W
   Yang, HQ
   Chen, XZ
AF Yang, Jing
   Xia, Yuanyuan
   Shen, Wei
   Yang, Haiquan
   Chen, Xianzhong
TI Development of a gene-coded biosensor to establish a high-throughput
   screening platform for salidroside production
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE salidroside; Genetically -encoded biosensor; Directed evolution; High
   -throughput screening
ID TRANSCRIPTIONAL REGULATOR HUCR; URIC-ACID; DEINOCOCCUS-RADIODURANS;
   RHODIOLA-ROSEA; SYSTEM; REVEALS; DESIGN; SENSOR
AB Metabolic engineering reconfigures cellular networks to produce value-added compounds from renewable substrates efficiently. However, identifying strains with desired phenotypes from large libraries through rational or random mutagenesis remains challenging. To overcome this bottleneck, an effective high-throughput screening (HTS) method must be developed to detect and analyze target candidates rapidly. Salidroside is an aromatic compound with broad applications in food, healthcare, medicine, and daily chemicals. However, there currently needs to be HTS methods available to monitor salidroside levels or to screen enzyme variants and strains for high-yield salidroside biosynthesis, which severely limits the development of microbial cell factories capable of efficiently producing salidroside on an industrial scale. This study developed a gene-encoded whole-cell biosensor that is specifically responsive to salidroside. The biosensor was created by screening a site-saturated mutagenic library of uric acid response regulatory protein binding bags. This work demonstrates the feasibility of monitoring metabolic flux with whole-cell biosensors for critical metabolites. It provides a promising tool for building salidroside high-yielding strains for high-throughput screening and metabolic regulation to meet industrial needs.
C1 [Yang, Jing; Xia, Yuanyuan; Shen, Wei; Yang, Haiquan; Chen, Xianzhong] Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China.
   [Yang, Jing; Xia, Yuanyuan; Shen, Wei; Yang, Haiquan; Chen, Xianzhong] Jiangnan Univ, Sch Biotechnol, Wuxi, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Xia, YY; Chen, XZ (corresponding author), Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China.
EM yyxia@jiangnan.edu.cn; xzchen@jiangnan.edu.cn
OI Xia, Yuanyuan/0000-0002-1054-2044
FU Key Research and Development Program of China [2022YFA0912204]; Jiangsu
   provincial key research and development program [BE2023685]
FX Acknowledgments This work was supported by the Key Research and
   Development Program of China (No. 2021YFC2100102-03) , the Key Research
   and Development Program of China (No. 2022YFA0912204) , and Jiangsu
   provincial key research and development program (No. BE2023685) .
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TC 2
Z9 3
U1 2
U2 46
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 18
PY 2024
VL 712
AR 149942
DI 10.1016/j.bbrc.2024.149942
EA APR 2024
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA SA9C1
UT WOS:001231846300001
PM 38642492
DA 2026-05-27
ER

PT J
AU Kurkin, VA
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AF Kurkin, V. A.
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TI Current Aspects of Standardization of Rhodiola rosea L. Rhizomes
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SO PHARMACEUTICAL CHEMISTRY JOURNAL
LA English
DT Article
DE Rhodiola rosea L; rhizomes and roots; rosavin; salidroside; HPLC
ID GOLDEN ROOT; SALIDROSIDE; QUALITY
AB Methodological approaches to the analysis of biologically active compounds in rhizomes and roots of Rhodiola rosea L. are substantiated. An HPLC method for quantitative determination of rosavin and salidroside, the predominant and diagnostically significant biologically active compounds in raw material of this plant, was developed. The content of rosavin in rhizomes and roots of R. rosea varied from 1.17 +/- 0.04% to 1.41 +/- 0.06%; of salidroside, from 1.63 +/- 0.05% to 2.88 +/- 0.12%, respectively. Statistical processing of the results indicated that the relative error of the mean content of rosavin and salidroside was less than +/- 5.0% with confidence probability 95%.
C1 [Kurkin, V. A.; Ryazanova, T. K.] Samara State Med Univ, 89 Chapaevskaya St, Samara 443099, Russia.
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RP Kurkin, VA (corresponding author), Samara State Med Univ, 89 Chapaevskaya St, Samara 443099, Russia.
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NR 25
TC 1
Z9 3
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0091-150X
EI 1573-9031
J9 PHARM CHEM J+
JI Pharm. Chem. J.
PD NOV
PY 2021
VL 55
IS 8
BP 793
EP 797
DI 10.1007/s11094-021-02496-9
EA NOV 2021
PG 5
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XE8VT
UT WOS:000719182200002
DA 2026-05-27
ER

PT J
AU Tang, Y
   Hou, Y
   Zeng, Y
   Hu, Y
   Zhang, Y
   Wang, XB
   Meng, XL
AF Tang, Yan
   Hou, Ya
   Zeng, Yong
   Hu, Yao
   Zhang, Yi
   Wang, Xiaobo
   Meng, Xianli
TI Salidroside attenuates CoCl2-simulated hypoxia injury in PC12
   cells partly by mitochondrial protection
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Hypoxia; Oxidative stress; Mitochondrial protection;
   Anti-apoptosis
ID CEREBRAL ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; MIR-210
AB Salidroside has been shown to exert neuroprotective effects against hypoxia. However, its mitochondrial protective mechanisms still remain elusive. The present study aimed to explore the mitochondrial protection of salidroside on PC12 cells and the involved mechanisms. The hypoxic injury of PC12 cells was triggered by CoCl2 stimulus. The contents of LDH release, SOD, GSH-PX, Na+-K+-ATPase, ATP, NAD(+) and NADH were determined by using commercial biochemical kits. Clark-type oxygen electrode and Seahorse XFe24 analyzer were employed to evaluate cell respiration and measure oxygen consumption rate (OCR), respectively. Mitochondrial swelling and mitochondrial membrane potential (MMP) were measured by using isolated mitochondria from the brain tissue of mice. The proteins expression of cleaved Caspase-3, HIF-1 alpha, ISCU1/2, COX10 and PFKP were tested by immunofluorescence and Western blot. While the genes expression of Caspase-3, HIF-1 alpha, ISCU1/2, COX10 and miR-210 were tested by quantitative real-time PCR (qRT-PCR) analysis. Salidroside alleviated CoCl2-induced oxidative stress in PC12 cells as evidenced by increased cell viability, decreased LDH release and elevated GSHPX and SOD activities. Salidroside could inhibit apoptosis by suppressing the level of cleaved Caspase-3 and Caspase-3. The enhanced mitochondrial energy synthesis by salidroside treatment was evidenced by the increases of Na+-K+-ATPase activity, ATP content, NAD(+)/NADH ratio, cellular respiration and OCR. In addition, salidroside could reduce mitochondrial swelling and MMP dissipation in isolated mitochondria. The results of immunofluorescence, Western blot and qRT-PCR analyses further revealed that salidroside raised the level of HIF-1 alpha, ISCU1/2, COX10, and miR-210. Collectively, salidroside can reverse CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection via inhibiting oxidative stress event, anti-apoptosis and enhancing mitochondrial energy synthesis.
C1 [Tang, Yan; Hou, Ya; Zeng, Yong] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China.
   [Hu, Yao] Chengdu Univ Tradit Chinese Med, Interdisciplinary Lab Exercise & Med, Chengdu 611137, Sichuan, Peoples R China.
   [Zhang, Yi] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Sichuan, Peoples R China.
   [Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Sichuan, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab SouthWestern Chinese Med Resources, Chengdu 611137, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine;
   Chengdu University of Traditional Chinese Medicine
RP Wang, XB; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab SouthWestern Chinese Med Resources, Chengdu 611137, Sichuan, Peoples R China.
EM VitaDrwang@cdutcm.edu.cn; xlm999@cdutcm.edu.cn
FU National Natural Science Foundation of China [82104533, 81973569];
   Science & Technology Department of Sichuan Province [2021YJ0175]; China
   Postdoctoral Science Foundation [2020M683273]; Project First-Class
   Disciplines Development of Chengdu University of Traditional Chinese
   Medicine [CZYJC1903]; National Key R&D Program of China
   [2017YFC1703904]; Regional Innovation and Cooperation Project of the
   Science & Technology Department of Sichuan Province [2020YFQ0032]; Key
   R&D and Transformation Program of the Science & Technology Department of
   Qinghai Province [2020-SF-C33]
FX This work was supported by the National Natural Science Foundation of
   China (82104533 and 81973569) , the Science & Technology Department of
   Sichuan Province (2021YJ0175) , the China Postdoctoral Science
   Foundation (2020M683273) , the Project First-Class Disciplines
   Development of Chengdu University of Traditional Chinese Medicine
   (CZYJC1903) , the National Key R&D Program of China (2017YFC1703904) ,
   the Regional Innovation and Cooperation Project of the Science &
   Technology Department of Sichuan Province (2020YFQ0032) , and the Key
   R&D and Transformation Program of the Science & Technology Department of
   Qinghai Province (2020-SF-C33) .
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NR 49
TC 37
Z9 44
U1 8
U2 71
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 5
PY 2021
VL 912
AR 174617
DI 10.1016/j.ejphar.2021.174617
EA NOV 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XQ7OH
UT WOS:000731733400002
PM 34748770
DA 2026-05-27
ER

PT J
AU Wang, ZX
   Xu, YL
   Xiong, HZ
AF Wang, Zixu
   Xu, Yunlong
   Xiong, Huazhong
TI Mechanism of salidroside promoting testosterone secretion induced by
   H2O2 in TM3 Leydig cells based on metabolomics and
   network pharmacology
SO FRONTIERS IN CHEMISTRY
LA English
DT Article
DE salidroside; oxidative stress; testosterone; metabolomics; network
   pharmacology
ID BIOSYNTHESIS; RESISTANCE; ARGININE
AB Oxidative stress-induced damage is a significant contributor to the impairment of Leydig cells in the testes, potentially diminishing the secretion of testosterone and other androgens, thereby resulting in testosterone deficiency. Salidroside, the principal bioactive constituent derived from Rhodiola, exhibits potent antioxidant properties. This study aims to investigate the underlying mechanisms by which salidroside enhances testosterone secretion. The study investigated the oxidative damage in TM3 cells induced by H2O2 and demonstrated that salidroside significantly decreased the levels of ROS and MDA, while increasing the levels of testosterone, SOD, GSH. These changes effectively ameliorated oxidative stress, mitigated oxidative damage, protected TM3 cells, and enhanced testosterone secretion. Additionally, UPLC-QE-Orbitrap-MS was employed to analyze the metabolomics of TM3 cells, identifying 28 distinct metabolites and associated metabolic pathways. Key metabolic pathways identified include Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Citrate cycle (TCA cycle), Phenylalanine metabolism, Pyruvate metabolism. Utilizing network pharmacology, the core targets of salidroside in enhancing testosterone secretion were further investigated, revealing the involvement of AMACR, CYP3A4, ECHS1, HSD17B10, MPO, and TYR. This discovery was confirmed by dry-wet analysis. To sum up, salidroside can reduce the level of oxidative stress and promote testosterone secretion through multiple metabolic pathways and multiple targets. In a word, salidroside may provide a new strategy for preventing and treating testosterone deficiency.
C1 [Wang, Zixu] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China.
   [Xu, Yunlong; Xiong, Huazhong] Changchun Univ Chinese Med, Affiliated Hosp, Prevent & Treatment Ctr, Changchun, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University of
   Chinese Medicine
RP Xu, YL; Xiong, HZ (corresponding author), Changchun Univ Chinese Med, Affiliated Hosp, Prevent & Treatment Ctr, Changchun, Peoples R China.
EM 16492111@qq.com; xhz1004@163.com
FU Jilin Science and Technology Development Plan Project
   [YDZJ202301ZYTS184]; National Famous Traditional Chinese Medicine
   Heritage Studio Project (Ji Traditional Chinese Medicine Fa) [2022, 48]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   financially supported by the Jilin Science and Technology Development
   Plan Project (No. YDZJ202301ZYTS184), National Famous Traditional
   Chinese Medicine Heritage Studio Project (Ji Traditional Chinese
   Medicine Fa [2022] No. 48).
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NR 33
TC 0
Z9 1
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2646
J9 FRONT CHEM
JI Front. Chem.
PD FEB 27
PY 2025
VL 13
AR 1544876
DI 10.3389/fchem.2025.1544876
PG 16
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 0BT1I
UT WOS:001443590800001
PM 40084278
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xing, Y
   Peng, HY
   Li, X
   Zhang, MX
   Gao, LL
   Yang, XE
AF Xing, Yan
   Peng, Hong-yun
   Li, Xia
   Zhang, Meng-xi
   Gao, Ling-ling
   Yang, Xiao-e
TI Extraction and isolation of the salidroside-type metabolite from zinc
   (Zn) and cadmium (Cd) hyperaccumulator Sedum alfredii Hance
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Article
DE Salidroside-type metabolite; Isolation; Hyperaccumulator; Sedum alfredii
   Hance
ID PHYTOREMEDIATION; BIOMASS; PHYTOEXTRACTION; REMOVAL
AB The active metabolite in the post-harvested biomass of zinc (Zn) and cadmium (Cd) hyperaccumulator Sedum alfredii Hance from phytoextraction is of great interest in China. The current study demonstrates that a salidroside-type metabolite can be yielded from the Zn/Cd hyperaccumulator S. alfredii biomass by means of sonication/ethanol extraction and macroporous resin column (AB-8 type) isolation. The concentrations of Zn and Cd in the salidroside-type metabolite were below the limitation of the national standards.
C1 [Xing, Yan; Peng, Hong-yun; Li, Xia; Zhang, Meng-xi; Gao, Ling-ling; Yang, Xiao-e] Zhejiang Univ, Minist Educ, Key Lab Environm Remediat & Ecol Hlth, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Peng, Hong-yun] Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China.
C3 Zhejiang University; Hohai University
RP Peng, HY (corresponding author), Zhejiang Univ, Minist Educ, Key Lab Environm Remediat & Ecol Hlth, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China.
EM penghongyun@zju.edu.cn
RI gao, lingling/MEO-7671-2025
OI Peng, Hongyun/0000-0001-5520-7074
FU Education Department of Zhejiang Province [Y201016563]; State Key
   Laboratory of Hydrology-Water Resources and Hydraulic Engineering
   [2009490711]; Zhejiang Provincial Qianjiang Talents for Science and
   Technology, China [2011R10026]
FX Project supported by the Education Department of Zhejiang Province (No.
   Y201016563), the State Key Laboratory of Hydrology-Water Resources and
   Hydraulic Engineering (No. 2009490711), and the Zhejiang Provincial
   Qianjiang Talents for Science and Technology (No. 2011R10026), China
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NR 13
TC 6
Z9 7
U1 4
U2 82
PU ZHEJIANG UNIV
PI HANGZHOU
PA EDITORIAL BOARD, 20 YUGU RD, HANGZHOU, 310027, PEOPLES R CHINA
SN 1673-1581
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD OCT
PY 2012
VL 13
IS 10
BP 839
EP 845
DI 10.1631/jzus.B1200002
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA 015XQ
UT WOS:000309480100009
PM 23024051
OA Bronze
DA 2026-05-27
ER

PT J
AU Xue, FY
   Guo, HL
   Hu, YY
   Liu, R
   Huang, LN
   Lv, HS
   Liu, CM
   Yang, MF
   Ma, LQ
AF Xue, Feiyan
   Guo, Huili
   Hu, Yingying
   Liu, Ran
   Huang, Lina
   Lv, Heshu
   Liu, Chunmei
   Yang, Mingfeng
   Ma, Lanqing
TI Expression of Codon-Optimized Plant Glycosyltransferase UGT72B14
   in Escherichia coli Enhances Salidroside Production
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID HIGH CELL-DENSITY; BIOSYNTHESIS; PROTEINS; GLUCOSYLTRANSFERASE;
   OVEREXPRESSION; RESVERATROL; CULTURE; YIELD
AB Salidroside, a plant secondary metabolite in Rhodiola, has been demonstrated to have several adaptogenic properties as amedicinal herb. Due to the limitation of plant source, microbial production of salidroside by expression of plant uridine diphosphate glycosyltransferase (UGT) is promising. However, glycoside production usually remains hampered by poor expression of plant UGTs in microorganisms. Herein, we achieved salidroside production by expression of Rhodiola UGT72B14 in Escherichia coli (E. coli) and codon optimization was accordingly applied. UGT72B14 expression was optimized by changing 278 nucleotides and decreasing the G+C content to 51.05% without altering the amino acid sequence. The effect of codon optimization on UGT72B14 catalysis for salidroside production was assessed both in vitro and in vivo. In vitro, salidroside production by codon-optimized UGT72B14 is enhanced because of a significantly improved protein yield (increased by 4.8-fold) and an equivalently high activity as demonstrated by similar kinetic parameters (K-M and V-max), compared to that by wild-type protein. In vivo, both batch and fed-batch cultivation using the codon-optimized gene resulted in a significant increase in salidroside production, which was up to 6.7 mg/L increasing 3.2-fold over the wild-type UGT72B14.
C1 [Xue, Feiyan; Guo, Huili; Hu, Yingying; Liu, Ran; Huang, Lina; Lv, Heshu; Liu, Chunmei; Yang, Mingfeng; Ma, Lanqing] Minist Agr, Key Lab Urban Agr North, Beijing 102206, Peoples R China.
   [Xue, Feiyan; Guo, Huili; Hu, Yingying; Liu, Ran; Huang, Lina; Lv, Heshu; Liu, Chunmei; Yang, Mingfeng; Ma, Lanqing] Beijing Agr Univ, Coll Biol Sci & Engn, Beijing 102206, Peoples R China.
   [Ma, Lanqing] Beijing Collaborat Innovat Ctr Ecoenvironm Improv, Beijing 102206, Peoples R China.
C3 Beijing University of Agriculture
RP Ma, LQ (corresponding author), Minist Agr, Key Lab Urban Agr North, Beijing 102206, Peoples R China.; Ma, LQ (corresponding author), Beijing Agr Univ, Coll Biol Sci & Engn, Beijing 102206, Peoples R China.; Ma, LQ (corresponding author), Beijing Collaborat Innovat Ctr Ecoenvironm Improv, Beijing 102206, Peoples R China.
EM lqma@bua.edu.cn
RI Guo, HUILI/OOM-4550-2025
FU Beijing Natural Science Foundation [2164059]; Beijing Outstanding Talent
   Project [2013D005021000003]; Funding Project for Scientific Research
   Quality Improvement in Beijing University of Agriculture [GJB2013006,
   GZL2015012]; Beijing Municipal Education Commission
   [CEFF-PXM2016_014207_000038]; National Natural Science Foundation of
   China [31300620, 31370674]; Foundation of Beijing Municipal Education
   Committee [KM20140020001]
FX This research was financially supported by "Beijing Natural Science
   Foundation (2164059)," "Beijing Outstanding Talent Project
   (2013D005021000003)," "Funding Project for Scientific Research Quality
   Improvement in Beijing University of Agriculture (GJB2013006,
   GZL2015012)," "Beijing Municipal Education Commission
   (CEFF-PXM2016_014207_000038)," "National Natural Science Foundation of
   China (31300620, 31370674)," and "Foundation of Beijing Municipal
   Education Committee (KM20140020001)." The authors also thank Mr.
   Mingcheng Zhang and Jianguo Yang for technical support.
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NR 31
TC 26
Z9 32
U1 6
U2 85
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2016
VL 2016
AR 9845927
DI 10.1155/2016/9845927
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA DU9FM
UT WOS:000382521700001
PM 27597978
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Yang, SX
   Xie, ZP
   Pei, TT
   Zeng, Y
   Xiong, QW
   Wei, H
   Wang, Y
   Cheng, WD
AF Yang, Sixia
   Xie, Zeping
   Pei, Tingting
   Zeng, Yi
   Xiong, Qiaowu
   Wei, Hui
   Wang, Yong
   Cheng, Weidong
TI Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1
   signaling pathway in Aβ1-42-induced Alzheimer's
   disease mice and glutamate-injured HT22 cells
SO CHINESE MEDICINE
LA English
DT Article
DE Alzheimer's disease; Salidroside; Ferroptosis; HT22 cells; Nuclear
   factor E2-related factor 2
ID OXIDATIVE STRESS; MECHANISMS; DAMAGE
AB Background: Alzheimer's disease (AD) is a neurodegenerative disease. Ferroptosis plays a critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is considered an important factor in ferroptosis. Studies have demonstrated that salidroside has a potential therapeutic effect on AD. The intrinsic effect of salidroside on ferroptosis is unclear. The purpose of this study was to investigate the protective effects and pharmacological mechanisms of salidroside on alleviating neuronal ferroptosis in A beta(1-)(42)-induced AD mice and glutamate-injured HT22 cells.
   Methods: HT22 cells were injured by glutamate (Glu), HT22 cells transfected with siRNA Nrf2, and A beta(1-)(42)-induced WT and Nrf2(-/-) AD mice were treated with salidroside. The mitochondria ultrastructure, intracellular Fe2+, reactive oxygen species, mitochondrial membrane potential, and lipid peroxidation of HT22 cells were detected. Malondialdehyde, reduced glutathione, oxidized glutathione disulfide, and superoxide dismutase were measured. The novel object recognition test, Y-maze, and open field test were used to investigate the protective effects of salidroside on A beta(1-)(42)-induced WT and Nrf2(-/-) AD mice. The protein expressions of PTGS2, GPX4, Nrf2, and HO1 in the hippocampus were investigated by Western blot.
   Results: Salidroside increased the cell viability and the level of MMP of Glu-injured HT22 cells, reduced the level of lipid peroxidation and ROS, and increased GPX4 and SLC7A11 protein expressions. These changes were not observed in siRNA Nrf2 transfected HT22 cells. Salidroside improved the ultrastructural changes in mitochondria of HT22 cells and A beta(1-42)-induced AD mice, but not in A beta(1-42)-induced Nrf2(-/-) AD mice. Salidroside increased protein expression levels of GPX4, HO1, and NQO1 and decreased protein expression of PTGS2 in A beta(1-42)-induced AD mice but not in A beta(1-)(42)-induced Nrf2(-/-) AD mice.
   Conclusions: Salidroside plays a neuroprotective role by inhibiting neuronal ferroptosis in A beta(1-42)-induced AD mice and Glu-injured HT22 cells, and its mechanism is related to activation of the Nrf2/HO1 signaling pathway.
C1 [Yang, Sixia; Xie, Zeping; Pei, Tingting; Zeng, Yi; Xiong, Qiaowu; Wei, Hui; Cheng, Weidong] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.
   [Wang, Yong] Southern Med Univ, Zhu Jiang Hosp, Dept Pharm, Guangzhou 510515, Peoples R China.
C3 Southern Medical University - China; Southern Medical University - China
RP Cheng, WD (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.
EM chengweidong888@sina.com
RI Cheng, Weidong/LMP-6222-2024
FU National Natural Science Foundation of China [82174149, 81973641];
   Guangzhou Municipal Science and Technology Project [201904010168];
   National Key Research and Development Program of China [2018YFC1704400,
   2018YFC1704404]
FX This research was funded by the National Natural Science Foundation of
   China (Grant numbers 82174149 and 81973641); the Guangzhou Municipal
   Science and Technology Project (Grant number 201904010168), and the
   National Key Research and Development Program of China (Grant number
   2018YFC1704400 and 2018YFC1704404).
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NR 53
TC 124
Z9 145
U1 17
U2 182
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD JUL 4
PY 2022
VL 17
IS 1
AR 82
DI 10.1186/s13020-022-00634-3
PG 18
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 2Q8BE
UT WOS:000820642500001
PM 35787281
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, G
   Nanding, A
AF Yu, Ge
   Nanding, Abiyasi
TI Salidroside overcomes cisplatin resistance in ovarian cancer via the
   inhibition of CRNDE-mediated autophagy
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Ovarian cancer; Cisplatin; Resistance; Salidroside; Autophagy; CRNDE
ID CELLS; PROTECTS; PROMOTES; SURVIVAL; CHEMOTHERAPY; CONTRIBUTES;
   KNOCKDOWN; INDUCTION; PATHWAY
AB Cisplatin (DDP) resistance significantly affects the survival rate of patients with ovarian cancer (OC). Autophagy is recognized as a common cause of resistance to DDP. This study aimed to investigate the impact of salidroside on OC progression and explore its potential regulatory effects on DDP resistance and autophagy. A DDP-resistant A2780 (A2780/DDP) cell line was induced by exposure to increasing DDP concentrations. The protein levels of autophagy proteins (p62, Beclin-1, ATG5, and LC3 II/LC3 I), apoptosis proteins (cleaved caspase-3 and cleaved caspase-9), and PI3K/AKT/mTOR pathway were determined by western blotting. Autophagic vacuoles in cells were observed with LC3 dyeing with confocal fluorescent microscopy. Cell viability and apoptosis were evaluated by cell counting kit-8 assays and flow cytometry. RT-qPCR was conducted to measure the relative levels of various lncRNAs in A2780 or A2780/DDP cells. A xenograft model was established by subcutaneous injection of 1 x 107 A2780 cells into the posterior flank of nude mice. Tumor size and weight were recorded. The expression of Ki67, cleaved caspase-3 and LC3 in tumor tissues was assessed by immunohistochemistry staining. The biodistribution of DDP in organs and blood of normal nude mice and tumors of tumor-bearing mice was detected using the ICP-MS. Hematoxylin-eosin staining was used to assess the histopathological changes of kidney, liver, and spleen sections. For in vitro analysis, autophagy was enhanced in DDP-resistant A2780 cells. Additionally, salidroside inhibits DDP resistance to A2780 cells via autophagy inhibition. Mechanistically, salidroside downregulated CRNDE in DDP-resistant A2780 cells. CRNDE knockdown inhibited autophagy, while CRNDE overexpression reversed the protective effects of salidroside. Additionally, salidroside activated the PI3K/AKT/mTOR pathway in DDP-resistant A2780 cells, and inhibition of PI3K reversed the effect of salidroside on inhibiting autophagy and apoptosis of A2780/DDP cells. For in vivo analysis, salidroside inhibited tumor growth, autophagy, and nephrotoxicity of DDP. Additionally, salidroside downregulated CRNDE and activated PI3K/AKT/mTOR signaling in vivo. Salidroside prevents autophagy-mediated DDP resistance in OC by downregulating lncRNA CRNDE and activating the PI3K/AKT/mTOR pathway.
C1 [Yu, Ge] Harbin Med Univ, Dept Gynecol, Canc Hosp, 150 Haping Rd, Harbin, Heilongjiang, Peoples R China.
   [Nanding, Abiyasi] Harbin Med Univ, Dept Pathol, Canc Hosp, 150 Haping Rd, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University
RP Nanding, A (corresponding author), Harbin Med Univ, Dept Pathol, Canc Hosp, 150 Haping Rd, Harbin, Heilongjiang, Peoples R China.
EM abiyasi001@163.com
FU BeiJing Heart To Heart Foundation
FX The authors appreciate the help of Harbin Medical University Cancer
   Hospital.
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Z9 6
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD MAY
PY 2025
VL 480
IS 5
BP 3097
EP 3116
DI 10.1007/s11010-024-05168-w
EA DEC 2024
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2EA7I
UT WOS:001370712800001
PM 39636431
DA 2026-05-27
ER

PT J
AU Luo, ZQ
   Ma, XY
   Liu, Y
   Lu, LN
   Yang, RR
   Yu, GH
   Sun, MH
   Xin, SK
   Tian, SM
   Chen, XJ
   Zhao, HY
AF Luo, Zhiqiang
   Ma, Xiaoyun
   Liu, Yang
   Lu, Lina
   Yang, Ruirui
   Yu, Guohua
   Sun, Mohan
   Xin, Shaokun
   Tian, Simin
   Chen, Xinjing
   Zhao, Haiyu
TI An Approach to Characterizing the Complicated Sequential Metabolism of
   Salidroside in Rats
SO MOLECULES
LA English
DT Article
DE salidroside; sequential metabolism; in situ closed-loop
ID IN-VITRO; VIVO; APOPTOSIS; INJURY
AB Metabolic study of bioactive compounds that undergo a dynamic and sequential process of metabolism is still a great challenge. Salidroside, one of the most active ingredients of Rhodiola crenulata, can be metabolized in different sites before being absorbed into the systemic blood stream. This study proposed an approach for describing the sequential biotransformation process of salidroside based on comparative analysis. In vitro incubation, in situ closed-loop and in vivo blood sampling were used to determine the relative contribution of each site to the total metabolism of salidroside. The results showed that salidroside was stable in digestive juice, and it was metabolized primarily by the liver and the intestinal flora and to a lesser extent by the gut wall. The sequential metabolism method described in this study could be a general approach to characterizing the metabolic routes in the digestive system for natural products.
C1 [Luo, Zhiqiang; Ma, Xiaoyun; Liu, Yang; Lu, Lina; Yang, Ruirui; Yu, Guohua; Sun, Mohan; Tian, Simin; Chen, Xinjing] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.
   [Xin, Shaokun] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.
   [Zhao, Haiyu] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
C3 Beijing University of Chinese Medicine; Capital Medical University;
   China Academy of Chinese Medical Sciences; Institute of Chinese Materia
   Medica, CACMS
RP Liu, Y (corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.; Zhao, HY (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
EM lzq4y3r@126.com; sijidehuaiye@126.com; liuyang@bucm.edu.cn;
   luludc399@163.com; yangrr5021@126.com; sufei_sophie@163.com;
   m13001147155@163.com; xyyzxxx@163.com; tiansimin1990@163.com;
   chxj9208@sina.com; zhyzhy007@gmail.com
RI yu, guo/PDW-7724-2025
FU National Natural Science Foundation of China [30801510, 81274042]
FX This work was supported by the National Natural Science Foundation of
   China (30801510 and 81274042).
CR Fan MH, 2008, EUR FOOD RES TECHNOL, V227, P167, DOI 10.1007/s00217-007-0706-9
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NR 23
TC 18
Z9 20
U1 1
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUN
PY 2016
VL 21
IS 6
DI 10.3390/molecules21060706
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DP8ON
UT WOS:000378757600032
PM 27248984
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gu, JK
   Hua, RW
   Wu, HY
   Guo, CX
   Hai, Z
   Xiao, Y
   Yeung, WSB
   Liu, K
   Babayev, E
   Wang, TR
AF Gu, Jingkai
   Hua, Renwu
   Wu, Huayan
   Guo, Chenxi
   Hai, Zhuo
   Xiao, Yuan
   Yeung, William S. B.
   Liu, Kui
   Babayev, Elnur
   Wang, Tianren
TI Salidroside Improves Oocyte Competence of Reproductively Old Mice by
   Enhancing Mitophagy
SO AGING CELL
LA English
DT Article
DE aging; ART; egg; IVF; mitochondria; ovary
ID MITOCHONDRIAL-FUNCTION; RHODIOLA-ROSEA; MATERNAL AGE; DYNAMICS; PROTECTS
AB The decline of oocyte quality with advanced maternal age has a detrimental effect on female fertility. However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study, we demonstrated that supplementation of salidroside improves the oocyte quality of reproductively old mice. Salidroside improved the maturation, fertilization, and developmental competence of oocytes from reproductively old mice by maintaining the normal spindle/chromosome structure and mitochondrial function. Oocyte transcriptomic and micro-proteomic analysis revealed that salidroside restores oocyte quality by enhancing mitophagy in reproductively old mice. Our studies provide a new theoretical foundation for utilizing salidroside to improve oocyte quality in reproductively old females in the context of natural fertility or assisted reproduction.
C1 [Gu, Jingkai; Hua, Renwu; Wu, Huayan; Guo, Chenxi; Hai, Zhuo; Xiao, Yuan; Yeung, William S. B.; Liu, Kui; Wang, Tianren] Univ Hong Kong, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.
   [Gu, Jingkai; Yeung, William S. B.; Liu, Kui] Univ Hong Kong, Li Ka Shing Fac Med, Dept Obstet & Gynaecol, Hong Kong, Peoples R China.
   [Babayev, Elnur] Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA.
C3 University of Hong Kong; University of Hong Kong; Northwestern
   University; Feinberg School of Medicine
RP Wang, TR (corresponding author), Univ Hong Kong, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.; Babayev, E (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA.
EM elnur.babayev@northwestern.edu; wtrcmu@126.com
RI Guo, Chenxi/KRO-6448-2024; 华, 仁武/IZQ-2864-2023
OI Gu, Jingkai/0000-0002-9092-1860
FU National Natural Science Foundation of China; Shenzhen Medical Academy
   of Research and Translation [C2301007]; Shenzhen Science and Technology
   Program, China [RCYX20200714114705073, KQTD20190929172749226]; NIH/NICHD
   [K12 HD050121];  [82371665]
FX The authors thank Prof. Kui Liu and his team members Dr. Zexiong Lin,
   Dr. Haiwei Feng, Dr. Jiahuan Zheng, and Dr. Zhe Hu from the University
   of Hong Kong for their invaluable technical support with the animal
   experiments. This study was supported by the National Natural Science
   Foundation of China (No. 82371665), Shenzhen Medical Academy of Research
   and Translation (No. C2301007), and Shenzhen Science and Technology
   Program, China (Nos. RCYX20200714114705073 and KQTD20190929172749226).
   Elnur Babayev is supported by NIH/NICHD (K12 HD050121).
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NR 44
TC 8
Z9 9
U1 16
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9718
EI 1474-9726
J9 AGING CELL
JI Aging Cell
PD MAY
PY 2025
VL 24
IS 5
AR e14475
DI 10.1111/acel.14475
EA JAN 2025
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 2OS9M
UT WOS:001392961200001
PM 39789811
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, ZH
   Mu, XR
   Wang, QS
   Zhou, ZT
   Wang, ZJ
   Wang, YX
   Liu, QY
   Lin, WX
   Qin, FF
   Pan, HT
   Huang, JM
   Gu, Y
   Li, Q
   Jiang, YW
   Lu, SF
   Wang, Q
   Tan, SZ
   Lu, ZG
AF Li, Zhonghao
   Mu, Xinru
   Wang, Qisheng
   Zhou, Ziting
   Wang, Zijing
   Wang, Yuxuan
   Liu, Qingyang
   Lin, Weixin
   Qin, Fenfen
   Pan, Haotian
   Huang, Jiamin
   Gu, Yun
   Li, Qian
   Jiang, Yongwei
   Lu, Shengfeng
   Wang, Qian
   Tan, Shanzhong
   Lu, Zhigang
TI Salidroside attenuates the acquisition of morphine-induced conditioned
   place preference in mice via improving neurosynaptic plasticity in the
   ventral tegmental area
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE conditioned place preference; morphine addiction; PI3K-AKT; salidroside;
   synaptic plasticity; VTA
ID RHODIOLA-ROSEA L.; FOCAL CEREBRAL-ISCHEMIA; SYNAPTIC PLASTICITY;
   NUCLEUS-ACCUMBENS; CONCISE GUIDE; EXTINCTION; EXPRESSION; ADDICTION;
   NEURONS; STRESS
AB Background and PurposeRhodiola rosea has therapeutic effects in several neurological disease models and its ethanolic extract prevents the acquisition of morphine-induced conditioned place preference (CPP). We investigate the potential mechanism by which the active component of R. rosea attenuates the acquisition of morphine-induced CPP and explore its association with synaptic plasticity.Experimental ApproachUsing systematic network pharmacology, morphine-treated SH-SY5Y cells and cortical primary neurons, we identified the active component of R. rosea against morphine addiction in vitro. Morphine-induced CPP and additional behavioural tests were conducted after salidroside treatment. Synaptic function and structural plasticity changes in the ventral tegmental area (VTA) were characterised via immunofluorescence staining, fibre photometry and western blot. RNA sequencing, qPCR and western blotting were used to elucidate the mechanism of salidroside in attenuating the acquisition of morphine-induced CPP.Key ResultsWe identified salidroside as the key active component, which reduced intracellular Ca2+ levels in morphine-treated SH-SY5Y cells and reversed morphine-induced growth impairment in primary cortical neurons. Salidroside significantly inhibited the acquisition of morphine-induced CPP. Furthermore, salidroside reversed chronic morphine-induced alterations in synaptic function and structural plasticity in the VTA, as evidenced by both in vitro and in vivo data. Critically, salidroside enhanced neurosynaptic plasticity of dopaminergic neurons by upregulating PI3K-AKT signalling.Conclusion and ImplicationsOur findings demonstrate that salidroside improves the synaptic structural and functional plasticity of VTA dopaminergic neurons through upregulating PI3K-AKT signalling, thereby attenuating the acquisition of morphine-induced CPP. Overall, salidroside exhibits promising preclinical potential as a therapeutic candidate for attenuating the acquisition of morphine-induced CPP.
C1 [Li, Zhonghao; Tan, Shanzhong; Lu, Zhigang] Nanjing Univ Chinese Med, Nanjing Hosp, Dept Integrated TCM & Western Med, Nanjing 210023, Peoples R China.
   [Li, Zhonghao] Peking Univ, Natl Inst Drug Dependence, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China.
   [Li, Zhonghao; Mu, Xinru; Wang, Qisheng; Zhou, Ziting; Wang, Zijing; Wang, Yuxuan; Liu, Qingyang; Lin, Weixin; Qin, Fenfen; Pan, Haotian; Huang, Jiamin; Lu, Zhigang] Nanjing Univ Chinese Med, Coll Pharm, Nanjing, Peoples R China.
   [Wang, Yuxuan; Lu, Zhigang] Nanjing Univ Chinese Med, Sch Integrat Med, Nanjing, Peoples R China.
   [Gu, Yun; Li, Qian; Jiang, Yongwei; Lu, Shengfeng; Lu, Zhigang] Nanjing Univ Chinese Med, Minist Educ, Key Lab Acupuncture & Med Res, Nanjing, Peoples R China.
   [Wang, Qian] Nanjing Univ Chinese Med, Coll Int Educ, Nanjing 210023, Peoples R China.
C3 Nanjing University of Chinese Medicine; Peking University; Nanjing
   University of Chinese Medicine; Nanjing University of Chinese Medicine;
   Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Tan, SZ; Lu, ZG (corresponding author), Nanjing Univ Chinese Med, Nanjing Hosp, Dept Integrated TCM & Western Med, Nanjing 210023, Peoples R China.; Wang, Q (corresponding author), Nanjing Univ Chinese Med, Coll Int Educ, Nanjing 210023, Peoples R China.; Lu, ZG (corresponding author), Nanjing Univ Chinese Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China.
EM aqqwang@126.com; fsyy01455@njucm.edu.cn; luzg@njucm.edu.cn
RI Qin, Fenfen/GRX-4320-2022; WANG, QIAN/AFH-4270-2022
OI Qin, Fenfen/0000-0003-4450-4721; Wang, Qisheng/0000-0002-9903-1258; 
FU National Key R&D Program of China; National Natural Science Foundation
   of China [82474341, 82174498]; Jiangsu Leading Talents in Traditional
   Chinese Medicine [SLJ0303]; Jiangsu Province Acupuncture-Moxibustion
   Integrated Education Ministry Key Laboratory Open Project [AML202306];
   Subject of Academic priority discipline of Jiangsu Higher Education
   Institutions [2024]; National Administration of Traditional Chinese
   Medicine Youth Qihuang Scholars Support Project [2022]; 
   [2024YFC3505405]
FX This work was supported by the National Key R&D Program of China
   (2024YFC3505405), National Natural Science Foundation of China (82474341
   and 82174498), Jiangsu Leading Talents in Traditional Chinese Medicine
   (SLJ0303), Jiangsu Province Acupuncture-Moxibustion Integrated Education
   Ministry Key Laboratory Open Project (AML202306), the Subject of
   Academic priority discipline of Jiangsu Higher Education Institutions
   (2024) and National Administration of Traditional Chinese Medicine Youth
   Qihuang Scholars Support Project (2022). We thank the web-based tool
   BioRender.
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NR 96
TC 0
Z9 0
U1 4
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD OCT
PY 2025
VL 182
IS 19
BP 4553
EP 4577
DI 10.1111/bph.70101
EA JUN 2025
PG 25
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7ES9B
UT WOS:001505126800001
PM 40490964
OA Bronze
DA 2026-05-27
ER

PT J
AU Zhang, JX
   Ma, LQ
   Yu, HS
   Zhang, H
   Wang, HT
   Qin, YF
   Shi, GL
   Wang, YN
AF Zhang, Ji-Xing
   Ma, Lan-Qing
   Yu, Han-Song
   Zhang, Hong
   Wang, Hao-Tian
   Qin, Yun-Fei
   Shi, Guang-Lu
   Wang, You-Nian
TI A tyrosine decarboxylase catalyzes the initial reaction of the
   salidroside biosynthesis pathway in Rhodiola sachalinensis
SO PLANT CELL REPORTS
LA English
DT Article
DE Over-expression; Rhodiola sachalinensis; Salidroside; Tyrosine
   decarboxylase (TyrDC); Tyrosol
ID POLYGONUM-CUSPIDATUM; 3-INTRON GENE; CULTURES; GLUCOSYLTRANSFERASE;
   OVEREXPRESSION; ACCUMULATION; EXPRESSION; CLONING
AB Salidroside, the 8-O-beta-D-glucoside of tyrosol, is the main bioactive component of Rhodiola species and is found mainly in the plant roots. It is well known that glucosylation of tyrosol is the final step in the biosynthesis of salidroside; however, the biosynthetic pathway of tyrosol and its regulation are less well understood. A summary of the results of related studies revealed that the precursor of tyrosol might be tyramine, which is synthesized from tyrosine. In this study, a cDNA clone encoding tyrosine decarboxylase (TyrDC) was isolated from Rhodiola sachalinensis A. Bor using rapid amplification of cDNA ends. The resulting cDNA was designated RsTyrDC. RNA gelblot analysis revealed that the predominant sites of expression in plants are the roots and high levels of transcripts are also found in callus tissue culture. Functional analysis revealed that tyrosine was best substrate of recombinant RsTyrDC. The over-expression of the sense-RsTyrDC resulted in a marked increase of tyrosol and salidroside content, but the levels of tyrosol and salidroside were 274 and 412%, respectively, lower in the antisense-RsTyrDC transformed lines than those in the controls. The data presented here provide in vitro and in vivo evidence that the RsTyrDC can regulate the tyrosol and salidroside biosynthesis, and the RsTyrDC is most likely to have an important function in the initial reaction of the salidroside biosynthesis pathway in R. sachalinensis.
C1 [Ma, Lan-Qing; Zhang, Hong; Qin, Yun-Fei; Shi, Guang-Lu; Wang, You-Nian] China Agr Univ, Key Lab Urban Agr N, Minist Agr Peoples Republ China, Beijing 102206, Peoples R China.
   [Yu, Han-Song] Jilin Agr Univ, Food Sci & Engn Coll, Changchun 130118, Peoples R China.
   [Wang, Hao-Tian] Jilin Univ, Sch Pharmaceut Sci, Changchun 130012, Peoples R China.
   [Zhang, Ji-Xing] Inner Mongolia Univ Nationalities, Coll Life Sci, Tongliao 028043, Peoples R China.
C3 China Agricultural University; Jilin Agricultural University; Jilin
   University; Inner Mongolia Minzu University
RP Shi, GL (corresponding author), China Agr Univ, Key Lab Urban Agr N, Minist Agr Peoples Republ China, Beijing 102206, Peoples R China.
EM glshi@bac.edu.cn; lqma@bac.edu.cn
RI guanglu, Shi/JRY-5435-2023
OI Yu, Hansong/0000-0002-7207-4936
FU National Natural Science Foundation of China [30872029, 30900112]; Key
   Natural Science Foundation of Beijing Municipality [5111001, 6071001,
   6092007]; Academic Human Resources Development in Institutions of Higher
   Learning Under the Jurisdiction of Beijing Municipality [PHR20090516,
   PHR201108279]; Foundation of Beijing Municipal Education Committee
   [KM201110020001]; Natural Science Foundation of Inner Mongolia
   [2010BS0502]
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 30872029 and 30900112) and Key Natural Science Foundation of
   Beijing Municipality (Nos. 5111001, 6071001 and 6092007), and Funding
   Project for Academic Human Resources Development in Institutions of
   Higher Learning Under the Jurisdiction of Beijing Municipality (Nos.
   PHR20090516 and PHR201108279), and Foundation of Beijing Municipal
   Education Committee (No. KM201110020001), and Natural Science Foundation
   of Inner Mongolia (No. 2010BS0502).
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NR 22
TC 38
Z9 50
U1 1
U2 55
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0721-7714
J9 PLANT CELL REP
JI Plant Cell Reports
PD AUG
PY 2011
VL 30
IS 8
BP 1443
EP 1453
DI 10.1007/s00299-011-1053-7
PG 11
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 806GU
UT WOS:000293795100008
PM 21538102
DA 2026-05-27
ER

PT J
AU Ge, CY
   Zhang, JL
   Feng, F
AF Ge, Chiyu
   Zhang, Junli
   Feng, Feng
TI Salidroside enhances the anti-cancerous effect of imatinib on human
   acute monocytic leukemia via the induction of autophagy-related
   apoptosis through AMPK activation
SO RSC ADVANCES
LA English
DT Article
ID CHRONIC MYELOID-LEUKEMIA; RHODIOLA-ROSEA-L.; CELLS; DASATINIB; MTOR
AB As the typical tyrosine kinase inhibitor, imatinib has been the first-line antineoplastic agent for both chronic myeloid leukemia and acute lymphoblastic leukemia. However, a large number of patients are still resistant to the benefits of imatinib, and they have a dissatisfactory prognosis. Salidroside, a compound that is extracted from natural plants, has been reported to have an excellent anticancer effect and few side effects. In the present study, we have developed a new combination therapy strategy of salidroside and imatinib for combating the growth of acute lymphoblastic leukemia. As demonstrated by the anti-proliferation assay, salidroside exhibited excellent cytotoxicity against myeloid leukemia cells. Moreover, cells treated by the combination therapy of salidroside and imatinib displayed a clear lower growth rate than cells only treated by imatinib, indicating that salidroside has a positive effect on enhancing the cytotoxicity of imatinib against leukemia cells. Subsequently, the underlying mechanisms were investigated. The results revealed that autophagy marker proteins in leukemia cells, including LC3, p62, and Beclin1, displayed a significant expression change after treating them with salidroside plus imatinib, with the levels of LC3 and Beclin1 dramatically increasing while the expression of p62 was significantly decreased. Moreover, an obvious down-regulation of p-PI3K, p-AKT and p-mTOR expression levels in leukemia cells after treatment with salidroside plus imatinib suggested that the PI3K/mTOR pathway plays an important role in the process of cell apoptosis induced by salidroside or imatinib. Further studies showed that pre-incubating the cells with an autophagy inhibitor dramatically inhibited the ability of imatinib to induce autophagy, but did not inhibit the ability of salidroside. The underlying causes were subsequently explored and the results showed that silencing AMPK alpha 1, the most important regulator of autophagy, dramatically attenuates the ability of salidroside to induce cell apoptosis. These results together indicated that salidroside enhances the cytotoxicity of imatinib on acute monocytic leukemia via the induction of autophagy-related apoptosis through AMPK activation. The unique advantages of combination therapy were further confirmed by in vivo experiments, with the tumor-bearing cells treated with salidroside plus imatinib achieving the best anti-tumor effect.
C1 [Ge, Chiyu; Zhang, Junli; Feng, Feng] Jiangsu Food & Pharmaceut Sci Coll, Sch Pharm, Meicheng Rd 4, Huaian City 223003, Jiangsu, Peoples R China.
C3 Jiangsu Food & Pharmaceutical Science College
RP Zhang, JL (corresponding author), Jiangsu Food & Pharmaceut Sci Coll, Sch Pharm, Meicheng Rd 4, Huaian City 223003, Jiangsu, Peoples R China.
EM zhangjunlijl@sina.com
FU Major University Science Research Project of Jiangsu Province
   [18KJA36002]; Huai'an Science and Technology Poverty Alleviation Project
   [HAN201801]
FX The present research is supported by the subjects of the Major
   University Science Research Project of Jiangsu Province (18KJA36002).
   This study was also supported by the Huai'an Science and Technology
   Poverty Alleviation Project (HAN201801).
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NR 34
TC 8
Z9 8
U1 0
U2 14
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PD AUG 12
PY 2019
VL 9
IS 43
BP 25022
EP 25033
DI 10.1039/c9ra01683j
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA IR6UB
UT WOS:000481573800040
PM 35528698
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Huang, LT
   Huang, ZX
   Lin, WJ
   Wang, L
   Zhu, XB
   Chen, X
   Yang, SW
   Lv, C
AF Huang, Lintuo
   Huang, Zhengxiang
   Lin, Wenjun
   Wang, Lu
   Zhu, Xiongbai
   Chen, Xin
   Yang, Shengwu
   Lv, Chen
TI Salidroside suppresses the growth and invasion of human osteosarcoma
   cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3
   signaling pathway
SO INTERNATIONAL JOURNAL OF ONCOLOGY
LA English
DT Article
DE apoptosis; cell-cycle; invasion; osteosarcoma; salidroside
ID INDUCED APOPTOSIS; CANCER; PROLIFERATION; MIGRATION; MICRORNA-21;
   CARCINOMA; SURVIVAL
AB Previous research has reported that salidroside exerts antitumor properties on numerous types of tumor cells; however, its effect on osteosarcoma cells remains unknown. The present study aimed to investigate the effects of salidroside on the viability, apoptosis and invasion of osteosarcoma cells in vitro, and determine the underlying mechanism of action. The results of an MTT revealed that salidroside suppressed the viability of osteosarcoma cells (MG63 and U2OS cells) in a time- and concentration-dependent manner. The results of cell morphological analysis (profile observations and Hoechst 33258 staining) and the detection of apoptosis by flow cytometry further indicated that the decrease in osteosarcoma cell viability induced by salidroside was associated with cell apoptosis. Western blot analysis not only confirmed these results but also suggested that salidroside induced the apoptosis of osteosarcoma cells by activating the caspase-9-dependent apoptotic pathway. In addition, we reported that salidroside induced G(0)/G(1) phase arrest and suppressed the invasion of osteosarcoma cells, as measured by flow cytometric cell cycle analysis and a Transwell invasion assay, respectively. Western blot analysis confirmed the aforementioned results. Furthermore, our findings demonstrated that salidroside induced the apoptosis, G(0)/G(1) phase arrest and suppressed the invasion of osteosarcoma cells by inhibiting the janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway, as determined by western blot analysis. In summary, the findings of the present study suggested that salidroside may inhibit the progression of osteosarcoma by suppressing the growth and invasion of osteosarcoma cells. Furthermore, the investigations into the underlying mechanism demonstrated that salidroside exerted notable antitumor activity in osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.
C1 [Huang, Lintuo; Huang, Zhengxiang; Lin, Wenjun; Wang, Lu; Zhu, Xiongbai; Chen, Xin; Yang, Shengwu; Lv, Chen] Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanbaixiang St, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Lv, C (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanbaixiang St, Wenzhou 325000, Zhejiang, Peoples R China.
EM lvchen136@sina.com
RI lin, wenjun/LMN-1733-2024; Lu, Wang/JVO-0416-2024
OI zhu, xiongbai/0000-0002-5089-9312; Lv, Chen/0000-0001-7756-1218
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NR 44
TC 23
Z9 28
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1019-6439
EI 1791-2423
J9 INT J ONCOL
JI Int. J. Oncol.
PD JUN
PY 2019
VL 54
IS 6
BP 1969
EP 1980
DI 10.3892/ijo.2019.4781
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA IL6WW
UT WOS:000477432000006
PM 31081055
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Lu, ZY
   Jiang, GZ
   Chen, Y
   Wang, J
   Muhammad, I
   Zhang, L
   Wang, R
   Liu, FP
   Li, R
   Qian, F
   Li, JC
AF Lu, Ziyin
   Jiang, Guozheng
   Chen, Ying
   Wang, Jian
   Muhammad, Ishfaq
   Zhang, Ling
   Wang, Rui
   Liu, Fangping
   Li, Rui
   Qian, Feng
   Li, Jichang
TI Salidroside attenuates colistin-induced neurotoxicity in RSC96 Schwann
   cells through PI3K/Akt pathway
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Colistin; RSC96 Schwann cells; Salidroside; Oxidative stress; PI3K/Akt
   pathway
ID SULFATE-INDUCED NEUROTOXICITY; GRAM-NEGATIVE BACTERIA; ASCORBIC-ACID
   PROTECTS; PC12 CELLS; INDUCED APOPTOSIS; OXIDATIVE STRESS; MICROGLIAL
   ACTIVATION; GINSENOSIDE RG1; BAD BUGS; MODULATION
AB Neurotoxicity is a key dose-limiting factor for colistin therapy. This study aimed to investigate the protective effect of Salidroside on colistin-induced neurotoxicity in RSC96 Schwann cells and the underlying mechanisms. After Salidroside (12.5, 25, 50 mu g/mL) treatment for 2 h, the cells were cultured with 250 mu g/mL colistin for 24 h. In order to investigate the role of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, the cells were pre-treated with LY294002 (12.5 mu mol/L, a specific inhibitor of PI3K phosphorylation) for 1 h before Salidroside (50 mu g/mL) treatment, then were co-cultured with colistin (250 mu g/mL) for 24 h. The results showed that colistin treatment could induce apoptotic cell death which was associated with oxidative stress injury. Salidroside could reduce colistin-induced neurotoxicity, decrease the effect of colistin on the reduced expression levels of p-Akt and Bcl-2, and increased the expresion of Bax, release of Cyt c, and activation of caspase-3. However, the protective effect of Salidroside against colistin-induced apoptosis was partly abolished by LY294002. These findings suggest that Salidroside could attenuate colistin-induced neurotoxicity in RSC96 Schwann cells via the PI3K/Akt pathway. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Lu, Ziyin; Jiang, Guozheng; Chen, Ying; Wang, Jian; Muhammad, Ishfaq; Zhang, Ling; Wang, Rui; Liu, Fangping; Li, Rui; Qian, Feng; Li, Jichang] Northeast Agr Univ, Coll Vet Med, 59 Mucai St, Harbin 150030, Peoples R China.
C3 Northeast Agricultural University - China
RP Li, JC (corresponding author), Northeast Agr Univ, Coll Vet Med, 59 Mucai St, Harbin 150030, Peoples R China.
EM lijichang@neau.edu.cn
RI /AAN-8960-2020; Ishfaq, Muhammad/U-9965-2019
OI Ishfaq, Muhammad/0000-0003-1376-8986
FU National Natural Science Foundation of China [31272613, 31472240]
FX This work was supported by the National Natural Science Foundation of
   China (31272613 and 31472240).
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NR 43
TC 31
Z9 37
U1 0
U2 21
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD JUN 1
PY 2017
VL 271
BP 67
EP 78
DI 10.1016/j.cbi.2017.04.027
PG 12
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA EW4AL
UT WOS:000402444300009
PM 28465020
DA 2026-05-27
ER

PT J
AU Wen, B
   Zhou, KR
   Hu, CY
   Chen, JH
   Xu, K
   Liang, T
   He, BH
   Chen, L
   Chen, J
AF Wen, Bin
   Zhou, Keru
   Hu, Caiyin
   Chen, Jiehui
   Xu, Kai
   Liang, Tao
   He, Benhong
   Chen, Ling
   Chen, Juan
TI Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK
   Dependent and Independent Pathways to Maintain Mitochondrial Quality
   Control
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Salidroside; Cerebral Ischemia; Mitochondrial Quality Control; AMPK
   Signaling; Mice
ID CELL-SURVIVAL; AUTOPHAGY; STROKE; HOMEOSTASIS; DYSFUNCTION; NETWORK;
   DISEASE; FUSION
AB Salidroside, an active ingredient in Rhodiola rosea, has potent protective activity against cerebral ischemia. However, the mechanisms underlying its pharmacological actions are poorly understood. In this study, we employed a mouse middle cerebral artery occlusion (MCAO) and cellular oxygen and glucose deprivation (OGD) models to test the hypothesis that salidroside may restore mitochondrial quality control in neurons by modulating the relevant signaling. The results indicated that salidroside mitigated almost 40% the ischemia-induced brain infarct volumes in mice and the OGD-decreased viability of neurons to ameliorate the mitochondrial functions. Furthermore, salidroside treatment alleviated the OGD- or ischemia-induced imbalance of mitochondrial fission and fusion, mitophagy and promoted mitochondrial biogenesis in neurons by attenuating the AMPK activity. Moreover, salidroside alleviated 50% the OGD-promoted mitochondrial calcium fluorescence intensity and 5% mitochondria-associated membrane (MAM) area by down-regulating GRP75 expression independent of the AMPK signaling. Finally, similar findings were achieved in primary mouse neurons. Collectively, these data indicate that salidroside effectively restores the mitochondria dynamics, facilitates mitochondrial biogenesis by attenuating the AMPK signaling, and maintains calcium homeostasis in neurons independent of the AMPK activity.
C1 [Wen, Bin; Zhou, Keru; Chen, Ling] Huazhong Univ Sci & Thchnol, Tongji Med Coll, TongJi Hosp, Dept Neonatol, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China.
   [Wen, Bin; Chen, Jiehui; Xu, Kai; Chen, Juan] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Biochem & Mol Biol, 13 Hankou Aviat Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wen, Bin; Chen, Jiehui; Xu, Kai; Chen, Juan] Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, 13 Hankou Aviat Rd, Wuhan 430030, Hubei, Peoples R China.
   [Hu, Caiyin] Wuhan Red Cross Hosp, Dept Cardiol, Wuhan 430015, Peoples R China.
   [Liang, Tao] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Clin Lab, Wuhan 430030, Hubei, Peoples R China.
   [He, Benhong] Lichuan Peoples Hosp, Dept Cardiovasc Med, 12 Longchuan Ave, Lichuan 445400, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology
RP Chen, L (corresponding author), Huazhong Univ Sci & Thchnol, Tongji Med Coll, TongJi Hosp, Dept Neonatol, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China.; Chen, J (corresponding author), Huazhong Univ Sci & Technol, Sch Basic Med, Dept Biochem & Mol Biol, 13 Hankou Aviat Rd, Wuhan 430030, Hubei, Peoples R China.; Chen, J (corresponding author), Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, 13 Hankou Aviat Rd, Wuhan 430030, Hubei, Peoples R China.; He, BH (corresponding author), Lichuan Peoples Hosp, Dept Cardiovasc Med, 12 Longchuan Ave, Lichuan 445400, Hubei, Peoples R China.
EM lczyyhbh@163.com; chenling@tjh.tjmu.edu.cn; chenjuanlinda69@163.com
RI tao, liang/PXW-3328-2026
FU National Natural Science Foundation of China [81873725]; Hubei
   Province's Outstanding, Medical Academic Leader program; Scientific
   research project of traditional Chinese medicine of Wuhan Health
   Committee [WZ21A02]; Health Commission of Hubei Province [ZY2021M014]
FX This work was supported by the National Natural Science Foundation of
   China (81873725) to Juan Chen, Hubei Province's Outstanding, Medical
   Academic Leader program to Benhong He, Scientific research project of
   traditional Chinese medicine of Wuhan Health Committee (WZ21A02) to
   Caiying Hu and Health Commission of Hubei Province (No. ZY2021M014) to
   Ling Chen.
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NR 50
TC 10
Z9 13
U1 2
U2 35
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2022
VL 50
IS 04
BP 1133
EP 1153
DI 10.1142/S0192415X2250046X
PG 21
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA 2H0YA
UT WOS:000814023400010
PM 35543160
DA 2026-05-27
ER

PT J
AU Song, HJ
   Wang, JJ
   Wang, ML
   Dong, H
   Li, LJ
   Zhang, TY
   Zhou, SB
AF Song, Hanjun
   Wang, Jianjie
   Wang, Molin
   Dong, Hang
   Li, Lijiang
   Zhang, Tengyuan
   Zhou, Shaobo
TI Antitumor Effect of Salidroside on Mice Bearing HepA Hepatocellular
   Carcinoma
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE apoptosis; hepatocellular carcinoma; salidroside
ID TUMOR-CELL APOPTOSIS; INDUCTION; MECHANISMS; PAEONOL
AB Salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea L., has antiproliferative effects on tumour cells in mice. However it's antitumor mechanism remains largely unknown. In this study, 4 groups of mice bearing hepatocarcinoma cells were given treatment with vehicle alone, cyclophosphamide (25 mg/kg, i.p.) and salidroside, either 100 or 200 mg/kg (p.o.) for 14 days. The morphology of tumour specimens was analysed by transmission electron microscopy. Apoptotic cells in sections of mouse tumour tissue were analysed using an in situ apoptosis kit. The expression of Bcl-2, Bax and caspase 3 mRNA were examined with RT-PCR. The results showed that the tumour weights in groups 100 or 200 mg/kg/day of salidroside were reduced significantly (45.34 and 52.48% respectively), compared to vehicle groups. Salidroside increased apoptotic cells index, e.g. in 200 mg/kg group, it was four times higher compared to the control group. Even more, treatment with salidroside decreased Bcl-2 mRNA expression and increased Bax and caspase 3 mRNA expressions. These indicated that the antitumor mechanism of salidroside may induce tumour cell apoptosis in mice by triggering the mitochondrial-dependent pathway and activation of caspase 3.
C1 [Song, Hanjun; Wang, Jianjie; Wang, Molin; Zhang, Tengyuan] Jiamusi Univ, Coll Basic Med, 148 Xuefu St, Jiamusi 154007, Peoples R China.
   [Dong, Hang; Li, Lijiang] Jiamusi Univ, Affiliated Hosp 1, 348 Dexiang St, Jiamusi 154002, Peoples R China.
   [Zhou, Shaobo] Univ Bedfordshire, Dept Life Sci, Inst Biomed & Environm Sci & Technol, Luton LU1 3JU, Beds, England.
C3 Jiamusi University; Jiamusi University; University of Bedfordshire
RP Wang, JJ (corresponding author), Jiamusi Univ, Coll Basic Med, 148 Xuefu St, Jiamusi 154007, Peoples R China.
EM jmsdxjianjie@163.com
RI Zhou, Shaobo/I-1536-2019
OI Zhou, Shaobo/0000-0001-5214-2973
FU Natural Scientific Foundation of HeiLongJiang province [D201165]; Major
   Project of Jiamusi University [Sz2014-001]
FX This research was funded by the Natural Scientific Foundation of
   HeiLongJiang province (D201165) and supported by the Major Project of
   Jiamusi University (Sz2014-001).
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NR 27
TC 2
Z9 3
U1 0
U2 1
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2015
VL 34
IS 10
BP 1961
EP 1967
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DB4UL
UT WOS:000368509000008
DA 2026-05-27
ER

PT J
AU Liu, GL
   Lian, XF
   Xu, YH
   Li, Z
   Lv, Z
   Wang, C
   Yu, MM
AF Liu, Guilin
   Lian, Xiaofang
   Xu, Yihan
   Li, Zhuo
   Lv, Zhihua
   Wang, Cong
   Yu, Mingming
TI Determination of Salidroside and Betaine by 1H NMR for
   Quality Control of Xinnaoxin Commercial Products
SO REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
LA English
DT Article
DE Analytical validation; Quality control; Herbal preparation; Method
   validation; Phytopharmaceutical; Traditional Chinese medicine
ID NMR; IDENTIFICATION; DISCOVERY; INJURY
AB A validated and sensitive H-1 NMR method was developed for the qualitative and quantitative analysis of the two main components of "xinnaoxin" prescriptions, salidroside and betaine. For the quantitative analysis, the characteristic signals for H-3 and H-5 of salidroside at delta 7.08 ppm (2H, J = 8.58 Hz), as well as the equivalent methyl groups of betaine at delta 3.12 ppm, were selected. The verification of the analytical method was accurate and in conformity with the guidance of the Chinese Pharmacopoeia. Furthermore, it has been applied to the quality assurance of products from different pharmaceutical companies. The results show that the content of salidroside in different products was satisfactory consistent with the results determined by high-performance liquid chromatography. This work implied that H-1 NMR represents a feasible alternative to liquid chromatography for quantitation of salidroside and was suitable for the more comprehensive quality control of "xinnaoxin" commercial products by the simultaneous quantification of salidroside and betaine.
C1 [Liu, Guilin; Lian, Xiaofang; Xu, Yihan; Li, Zhuo; Lv, Zhihua; Wang, Cong; Yu, Mingming] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China.
   [Lv, Zhihua; Wang, Cong; Yu, Mingming] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China.
   [Lv, Zhihua; Wang, Cong; Yu, Mingming] Key Lab Glycosci & Glycotechnol Shandong Prov, Qingdao 266003, Peoples R China.
   [Lv, Zhihua; Wang, Cong; Yu, Mingming] Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China.
C3 Ocean University of China; Laoshan Laboratory
RP Wang, C; Yu, MM (corresponding author), Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China.; Wang, C; Yu, MM (corresponding author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China.; Wang, C; Yu, MM (corresponding author), Key Lab Glycosci & Glycotechnol Shandong Prov, Qingdao 266003, Peoples R China.; Wang, C; Yu, MM (corresponding author), Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China.
EM wangcong@ouc.edu.cn; yumingming@ouc.edu.cn
OI , wangcong/0000-0003-2818-406X
FU Shandong Provincial Natural Science Foundation, China [ZR2019BC025];
   Fundamental Research Funds for the Central Universities [202042005,
   201964019]
FX This study was funded by Shandong Provincial Natural Science Foundation,
   China (ZR2019BC025), and the "Fundamental Research Funds for the Central
   Universities" (202042005 and 201964019).
CR Beckonert O, 2007, NAT PROTOC, V2, P2692, DOI 10.1038/nprot.2007.376
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NR 32
TC 3
Z9 3
U1 0
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0102-695X
EI 1981-528X
J9 REV BRAS FARMACOGN
JI Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
PD AUG
PY 2021
VL 31
IS 4
BP 463
EP 469
DI 10.1007/s43450-021-00191-0
EA SEP 2021
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WN0IP
UT WOS:000698874700001
DA 2026-05-27
ER

PT J
AU Wang, JW
   Pan, YB
   Cao, YQ
   Zhou, W
   Lu, JG
AF Wang, Jiawen
   Pan, Yibin
   Cao, Yongqing
   Zhou, Wei
   Lu, Jingen
TI Salidroside regulates the expressions of IL-6 and defensins in
   LPS-activated intestinal epithelial cells through NF-κB/MAPK and STAT3
   pathways
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Defensin; IL-6; Intestinal epithelial cell; MAPK; NF-kappa B;
   Salidroside; STAT3
ID INFLAMMATORY-BOWEL-DISEASE; B KINASE; LIPOPOLYSACCHARIDE; HOMEOSTASIS;
   INHIBITOR
AB Objective(s): To reveal the detailed mechanism underlying the functions of salidroside on the inflammation of intestinal epithelial cells during IBD.
   Materials and Methods: Quantitative real-time PCR was employed to assess the expression of IL-6, IL-10, and a-defensins 5 and 6. ELISA assay was performed to measure the secretion of IL-6 and IL-10. MTT assay was used to determine the cell viability and proliferation. Western blot was used to assess the phosphorylation of NF-kB, Erk1/2, JNK, P38, JAK2, and STAT3.
   Results: Salidroside impaired the proliferation of intestinal epithelial cells at high concentrations (P< 0.05) and down-regulated interleukin-6 (IL-6) production induced by LPS (P<0.05). Western blot results showed that salidroside repressed the phosphorylation of NF-kB, Erk1/2, JNK, P38, JAK2 and STAT3 (P<0.05) and attenuated the activation of NF-kappa B, MAPK, and STAT3 pathways. Moreover, the expressions of alpha-defensin 5 and 6 were rescued by salidroside after LPS or SAC triggering (P<0.05).
   Conclusion: In summary, salidroside suppressed the expression of IL-6 and elevated the expression of defensins in LPS-activated intestinal epithelial cells through NF-kappa B/MAPK and STAT3 pathways. The mechanism revealed here may be potentially useful for the treatment of IBD with salidroside.
C1 [Wang, Jiawen; Pan, Yibin; Cao, Yongqing; Zhou, Wei; Lu, Jingen] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Anal & Intestinal Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Lu, JG (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Anal & Intestinal Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
EM lujingen2017@163.com
RI Wang, Jiawen/ONI-6711-2025
OI Wang, Jiawen/0000-0003-0979-7127
FU Traditional Chinese Medicine Scientific Research Project of Shanghai
   Municipal Commission of Health and Family Planning [2016LQ017]; Longhua
   hospital affiliated to Shanghai university of traditional Chinese
   medicine [2016YM03]; National Natural Science Foundation of China
   [81473683]; three-year-action-plan-construction project to further
   accelerate the development of traditional Chinese medicine in Shanghai
   [ZY(2018-2020)-CCCX-1007]
FX This work was supported by the Traditional Chinese Medicine Scientific
   Research Project of Shanghai Municipal Commission of Health and Family
   Planning (No. 2016LQ017), the research fund project of Longhua hospital
   affiliated to Shanghai university of traditional Chinese medicine (No.
   2016YM03), National Natural Science Foundation of China (No. 81473683),
   a three-year-action-plan-construction project to further accelerate the
   development of traditional Chinese medicine in Shanghai (No.
   ZY(2018-2020)-CCCX-1007).
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NR 32
TC 23
Z9 28
U1 0
U2 14
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JAN
PY 2019
VL 22
IS 1
BP 31
EP 37
DI 10.22038/ijbms.2018.26994.6602
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HC5OC
UT WOS:000451851300005
PM 30944705
DA 2026-05-27
ER

PT J
AU Zhang, JK
   Yang, L
   Meng, GL
   Yuan, Z
   Fan, J
   Li, D
   Chen, JZ
   Shi, TY
   Hu, HM
   Wei, BY
   Luo, ZJ
   Liu, J
AF Zhang, Jin-Kang
   Yang, Liu
   Meng, Guo-Lin
   Yuan, Zhi
   Fan, Jing
   Li, Dan
   Chen, Jian-Zong
   Shi, Tian-Yao
   Hu, Hui-Min
   Wei, Bo-Yuan
   Luo, Zhuo-Jing
   Liu, Jian
TI Protection by Salidroside against Bone Loss via Inhibition of Oxidative
   Stress and Bone-Resorbing Mediators
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; HYDROGEN-PEROXIDE; OSTEOBLASTIC DIFFERENTIATION;
   POSTMENOPAUSAL OSTEOPOROSIS; OSTEOCLAST FORMATION;
   MECHANICAL-PROPERTIES; ANTIOXIDANT SYSTEM; LIPID-PEROXIDATION; MC3T3-E1
   CELLS; STROMAL CELLS
AB Oxidative stress is a pivotal pathogenic factor for bone loss in mouse model. Salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea L, exhibits potent antioxidative effects. In the present study, we used an in vitro oxidative stress model induced by hydrogen peroxide (H2O2) in MC3T3-E1 cells and a murine ovariectomized (OVX) osteoporosis model to investigate the protective effects of salidroside on bone loss and the related mechanisms. We demonstrated that salidroside caused a significant (P < 0.05) elevation of cell survival, alkaline phosphatase (ALP) staining and activity, calcium deposition, and the transcriptional expression of Alp, Col1a1 and Osteocalcin (Ocn) in the presence of H2O2. Moreover, salidroside decreased the production of intracellular reactive oxygen species (ROS), and osteoclast differentiation inducing factors such as receptor activator of nuclear factor-kB ligand (RANKL) and IL-6 induced by H2O2. In vivo studies further demonstrated that salidroside supplementation for 3 months caused a decrease in malondialdehyde (MDA) and an increase in reduced glutathione (GSH) concentration in blood of ovariectomized mouse (P < 0.05), it also improved trabecular bone microarchitecture and bone mineral density in the fourth lumbar vertebra and distal femur. Our study indicated that the protection provided by salidroside in alleviating bone loss was mediated, at least in part, via inhibition of the release of bone-resorbing mediators and oxidative damage to bone-forming cells, suggesting that salidroside can be used as an effective remedy in the treatment or prevention of osteoporosis.
C1 [Zhang, Jin-Kang; Yang, Liu; Meng, Guo-Lin; Yuan, Zhi; Fan, Jing; Li, Dan; Hu, Hui-Min; Wei, Bo-Yuan; Luo, Zhuo-Jing; Liu, Jian] Fourth Mil Med Univ, Xijing Hosp, Inst Orthoped Surg, Xian 710032, Peoples R China.
   [Chen, Jian-Zong] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Peoples R China.
   [Shi, Tian-Yao] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Luo, ZJ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Inst Orthoped Surg, Xian 710032, Peoples R China.
EM zjluo@fmmu.edu.cn; zjk1271984@21cn.com
RI ; Yuan, Zhiquan/MEP-6825-2025; /AFR-6600-2022
OI Yang, Liu/0000-0002-6498-4702; 
FU Ministry of Science and Technology of China [2011CB964703]; National
   High Technology Research and Development Program 863 [2012AA020502];
   China Postdoctoral Science Foundation [20100480093]; National Natural
   Science Foundation of China [30901504]
FX This work was supported by Ministry of Science and Technology of China
   (2011CB964703), National High Technology Research and Development
   Program 863 (2012AA020502), China Postdoctoral Science Foundation
   (20100480093) and National Natural Science Foundation of China
   (30901504). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 45
TC 79
Z9 95
U1 1
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 20
PY 2013
VL 8
IS 2
AR e57251
DI 10.1371/journal.pone.0057251
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 093IE
UT WOS:000315184200230
PM 23437352
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, RH
   Ma, TF
   Yang, Q
   Xiao, WC
   Yin, L
   Yin, M
   Zhang, JS
   Wang, CH
AF Liu, Ru-Han
   Ma, Teng-Fei
   Yang, Qin
   Xiao, Wen-Chang
   Yin, Lu
   Yin, Miao
   Zhang, Jin-Song
   Wang, Chi-Hua
TI Salidroside suppresses proliferation and migration in prostate cancer
   via the PI3K/AKT pathway
SO CANCER BIOMARKERS
LA English
DT Article
DE Salidroside; prostate cancer; PC3; DU145; PI3K/AKT
ID IN-VITRO; CELLS; STATISTICS; APOPTOSIS; CHINA; MODEL
AB BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies in men. PCa is difficult to detect in its early stages, and most patients are diagnosed in the middle to late stages. At present, drug therapy for advanced PCa is still insufficient. Some patients develop drug resistance in the later stage of therapy, which leads to tumor recurrence, metastasis and even treatment failure. Therefore, it is crucial to find new and effective drugs to treat prostate cancer.
   OBJECTIVE: The aim of this study was to investigate the anti-cancer effect of salidroside, an active ingredient in a traditional Chinese herbal medicine, on PCa.
   METHODS: Two human PCa cell lines, PC3 and DU145, were cultured and treated with salidroside. Cell viability and proliferation ability were analyzed through CCK-8 and colony assays, and cell migration ability was detected by Transwell and Scratch assays. RT-PCR and WB were used to detected the expression levels of moleculars related to cell proliferation, apoptosis, migration, and AKT signaling pathway. Forthmore, we performed rescue experiments with agonist to verify the affected signaling pathway.
   RESULTS: Salidroside inhibited the proliferation, colony formation, and migration of PCa cells. Meanwhile, apoptosis of PCa cells was enhanced. Moreover, salidroside inhibited PI3K/AKT pathway in PCa cells. The treatment of AKT agonist 740Y-P abrogated the inhibitory effect of salidroside on the PI3K/AKT signaling pathway.
   CONCLUSIONS: Our study demonstrated that in PCa cells, salidroside inhibites proliferation and migration and promots apoptosis via inhibiting PI3K/AKT pathway.
C1 [Liu, Ru-Han] Huanggang Cent Hosp, Dept Combine Tradit Chinese & Western Med, Huanggang, Hubei, Peoples R China.
   [Ma, Teng-Fei] Huanggang Cent Hosp, Dept Neurol, Huanggang, Peoples R China.
   [Ma, Teng-Fei; Yang, Qin; Xiao, Wen-Chang; Yin, Lu; Yin, Miao] Huanggang Inst Translat Med, Huanggang, Hubei, Peoples R China.
   [Yang, Qin; Xiao, Wen-Chang] Huanggang Cent Hosp, Dept Cardiovasc Surg, Huanggang, Hubei, Peoples R China.
   [Zhang, Jin-Song] Huanggang Cent Hosp, Dept Urol, Huanggang, Peoples R China.
   [Wang, Chi-Hua] Huanggang Dis Control Ctr, Huanggang, Hubei, Peoples R China.
RP Zhang, JS (corresponding author), 11 Kaopeng St, Huanggang 438000, Hubei, Peoples R China.; Wang, CH (corresponding author), 99 Shengli St, Huanggang 438000, Hubei, Peoples R China.
EM song8105@163.com; 1091905608@qq.com
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NR 45
TC 8
Z9 11
U1 4
U2 17
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1574-0153
EI 1875-8592
J9 CANCER BIOMARK
JI Cancer Biomark.
PY 2023
VL 38
IS 3
BP 321
EP 332
DI 10.3233/CBM-220454
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA X6OT7
UT WOS:001099630200005
PM 37545219
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Xu, J
   Zhao, LY
   Zhang, XT
   Ying, KL
   Zhou, RR
   Cai, WM
   Wu, X
   Jiang, HR
   Xu, Q
   Miao, D
   Zeng, Y
   Yu, FJ
AF Xu, Jun
   Zhao, Luying
   Zhang, Xiangting
   Ying, Kanglei
   Zhou, Ruoru
   Cai, Weimin
   Wu, Xiao
   Jiang, Haoran
   Xu, Qian
   Miao, Dan
   Zeng, Yuan
   Yu, Fujun
TI Salidroside ameliorates acetaminophen-induced acute liver injury through
   the inhibition of endoplasmic reticulum stress-mediated ferroptosis by
   activating the AMPK/SIRT1 pathway
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Salidroside; Acute liver injury; Ferroptosis; Endoplasmic reticulum
   stress; AMP-activated protein kinase; SIRT1
ID CELL-DEATH; ER STRESS; APOPTOSIS; SUSCEPTIBILITY; INFLAMMATION;
   METABOLISM; INDUCTION; AUTOPHAGY; FAILURE; CHAC1
AB Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid peroxidation. Endoplasmic reticulum (ER) stress is a systemic response triggered by the accumulation of unfolded or misfolded proteins in the ER. Ferroptosis and ER stress have been proven to contribute to the progression of APAP-induced acute liver injury (ALI). It was reported that salidroside protects against APAP-induced ALI, but the potential mechanism remain unknown. In this study, male C57BL/6 J mice were intraperitoneally (i.p.) injected APAP (500 mg/kg) to induce an ALI model. Salidroside was i.p. injected at a dose of 100 mg/kg 2 h prior to APAP administration. Mice were sacrificed 12 h after APAP injection and the liver and serum of the mice were obtained for histological and biochemistry analysis. AML12 cells were used in in vitro assays. The results indicated that salidroside mitigated glutathione degradation via inhibiting cation transport regulator homolog 1 (CHAC1) to attenuate ferroptosis, and simultaneously suppressing PERK-eIF2 alpha-ATF4 axis-mediated ER stress, thus alleviating APAP-induced ALI. However, PERK activator CCT020312 and overexpression of ATF4 inhibited the protective function of salidroside on CHAC1-mediated ferroptosis. Besides this, activation of the AMPK/SIRT1 signaling pathway by salidroside was demonstrated to have a protective effect against APAP-induced ALI. Interestingly, selective inhibition of SIRT1 ameliorated the protective effects of salidroside on ER stress and ferroptosis. Overall, salidroside plays a significant part in the mitigation of APAP-induced ALI by activating the AMPK/SIRT1 signaling to inhibit ER stress-mediated ferroptosis in the ATF4-CHAC1 axis.
C1 [Xu, Jun; Zhao, Luying; Zhang, Xiangting; Ying, Kanglei; Zhou, Ruoru; Cai, Weimin; Wu, Xiao; Xu, Qian; Miao, Dan; Zeng, Yuan; Yu, Fujun] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou, Zhejiang, Peoples R China.
   [Jiang, Haoran] Wenzhou Med Univ, Affiliated Hosp 1, Dept Urol, Wenzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Zeng, Y; Yu, FJ (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou, Zhejiang, Peoples R China.
EM zengyuan121388@163.com; yufujun@wmu.edu.cn
RI Jiang, Haoran/IAR-3219-2023; weimin, Cai/HXU-3485-2023
FU National Natural Science Foundation of China [81970527]; Zhejiang
   Provincial Natural Science Foundation of China [Y23H030023]; Wenzhou
   Municipal Science and Technology Bureau [Y20220024]; Zhejiang Xinmiao
   Talent Project [2022R413C083]
FX The project was supported by the National Natural Science Foundation of
   China (No. 81970527), Zhejiang Provincial Natural Science Foundation of
   China (No. Y23H030023), Wenzhou Municipal Science and Technology Bureau
   (No. Y20220024), and Zhejiang Xinmiao Talent Project (No. 2022R413C083).
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NR 74
TC 54
Z9 62
U1 4
U2 34
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD SEP 1
PY 2023
VL 262
AR 115331
DI 10.1016/j.ecoenv.2023.115331
EA AUG 2023
PG 14
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA EL4U2
UT WOS:001139076500001
PM 37556956
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, BB
   Tang, JF
   Niu, M
   Zhu, RY
   Li, L
   Wang, LL
   Tian, YM
   Li, R
   Jia, QQ
   Zhao, DD
   Mo, FF
   Romanenko, EB
   Orekhov, AN
   Gao, SH
   Brömme, D
   Zhang, DW
AF Chen, Beibei
   Tang, Jinfa
   Niu, Ming
   Zhu, Ruyuan
   Li, Lin
   Wang, Lili
   Tian, Yimiao
   Li, Rui
   Jia, Qiangqiang
   Zhao, Dandan
   Mo, Fangfang
   Romanenko, Elena B.
   Orekhov, Alexander N.
   Gao, Sihua
   Bromme, Dieter
   Zhang, Dongwei
TI Comparative Study of the Pharmacokinetic Parameters for Salidroside in
   Normal and Estrogen-Deficient Female Rats after Oral Administration of
   an Aqueous Extract of Fructus Ligustri Lucidi using a Validated
   Ultra-Performance Liquid Chromatography Mass Spectrometry/Mass
   Spectrometry Method
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article
DE Fructus Ligustri Lucidi; ovariectomized rats; plasma characteristic;
   salidroside; ultra-performance liquid chromatography mass
   spectrometry/mass spectrometry
ID CHINESE HERBAL MEDICINE; METABOLITE P-TYROSOL; LC-MS DETERMINATION;
   OVARIECTOMIZED MICE; TISSUE DISTRIBUTION; PLASMA; RECEPTOR; OVARIAN;
   BONE; MS/MS
AB Background: Salidroside, one of the main active ingredients in Fructus Ligustri Lucidi (FLL), is well demonstrated to exert anti-osteoporotic effect. However, the plasma pharmacokinetic profile of salidroside in FLL in estrogen-deficient rats remains unknown. Objective: The objective was to develop a sensitive, rapid, and accurate ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for the determination of the pharmacokinetics profile of salidroside after oral administration of FLL aqueous extract in normal and ovariectomized (OVX) rats. Materials and Methods: OVX and normal rats were orally administrated with FLL at a bolus of 7 g/kg. Plasma samples were precipitated by methanol, and the supernatant was chromatographed by a Waters BEH C-18 column with a gradient elution of ammonium acetate and acetonitrile. Quantification was carried out on the electrospray ionization, positive multiple reaction monitoring modes. Results: The lower limit of detection was 50 ng/mL, and the dynamic linear range was 50-30,000 ng/mL with a value of R-2 > 0.99. The intra- and inter-day precisions were lower than 14.67%, and accuracy was in the range of 99.29%-103.37%. The recovery of salidroside ranged from 88.90% to 101.78%, with the matrix effect ranging from 85.53% to 100.45%. The t 1/2, MRT0-8, and apparent volume of distribution for salidroside increased in OVX rats. Conclusion: A sensitive, accurate, and rapid method was successfully established and validated for the determination of plasma characteristics of salidroside in Sprague-Dawley (SD) rats. The results suggest that ovariectomy could interfere with salidroside metabolism in SD rats.
C1 [Chen, Beibei; Zhu, Ruyuan; Li, Lin; Tian, Yimiao; Li, Rui; Jia, Qiangqiang; Zhao, Dandan; Mo, Fangfang; Gao, Sihua; Zhang, Dongwei] Beijing Univ Chinese Med, Tradit Chinese Med Sch, Diabet Res Ctr, Beijing 100029, Peoples R China.
   [Tang, Jinfa] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Zhengzhou, Peoples R China.
   [Niu, Ming] Beijing Univ Chinese Med, TCM Res Inst Gen PLA, 302 Hosp, Beijing, Peoples R China.
   [Wang, Lili] Beijing Univ Chinese Med, Modern Res Ctr TCM, Chinese Mat Med Sch, Beijing, Peoples R China.
   [Romanenko, Elena B.] Moscow MV Lomonosov State Univ, Dept Mol Basis Ontogenesis, Belozersky Inst Phys & Chem Biol, Moscow, Russia.
   [Orekhov, Alexander N.] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow, Russia.
   [Bromme, Dieter] Univ British Columbia, Fac Dent, Vancouver, BC, Canada.
C3 Beijing University of Chinese Medicine; Henan University of Traditional
   Chinese Medicine; Beijing University of Chinese Medicine; Beijing
   University of Chinese Medicine; Lomonosov Moscow State University;
   Russian Academy of Medical Sciences; Institute of General Pathology &
   Pathophysiology, RAMS; University of British Columbia
RP Zhang, DW (corresponding author), Beijing Univ Chinese Med, Tradit Chinese Med Sch, Diabet Res Ctr, Beijing 100029, Peoples R China.
EM dongwei1006@gmail.com
RI Mo, Fangfang/LPQ-9010-2024; ZHAO, DANDAN/JDD-3485-2023; Zhang,
   Dongwei/AAS-8384-2020
FU Beijing Municipal Natural Science Foundation [7172126]; National Natural
   Science Foundation of China [81874373]; Program for Innovative Research
   Team in University, China [IRT_17R11]
FX Financial supports came from Beijing Municipal Natural Science
   Foundation (Grant No. 7172126), National Natural Science Foundation of
   China (Grant No. 81874373), and the Program for Innovative Research Team
   in University, China (Grant No. IRT_17R11).
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PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD JUL-SEP
PY 2020
VL 16
IS 71
BP 471
EP 478
DI 10.4103/pm.pm_278_19
PG 8
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PF0FJ
UT WOS:000598740100004
DA 2026-05-27
ER

PT J
AU Chen, XF
   Li, XL
   Yang, M
   Song, Y
   Zhang, Y
AF Chen, Xiang-Fan
   Li, Xiao-Li
   Yang, Min
   Song, Yan
   Zhang, Yan
TI Osteoprotective effects of salidroside in ovariectomized mice and
   diabetic mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Ovariectomized; Diabetes; Osteoporosis; Calcium
ID FRUCTUS-LIGUSTRI-LUCIDI; CALCIUM-SENSING RECEPTOR; GENE-EXPRESSION;
   BONE; EXTRACT; OSTEOPOROSIS; BALANCE; KIDNEY
AB Salidroside, an active constituent from the root of Rhodiola rosea L., has multiple pharmacological effects, such as anti-cancer, anti-inflammatory and anti-oxidative properties, etc. However, its protective effect on bone tissue via regulating calcium homeostasis is yet to be determined. This study was performed to investigate if salidroside could protect against bone injuries induced by estrogen deficiency or hyperglycemia through modulating calcium homeostasis. Ovariectomized (OVX) mice and diabetic mice were treated with salidroside (20 mg/kg) for 6 weeks. Safranin O staining and micro-CT were performed on the distal metaphysis of femur. The calcium content in serum, urine and femur was measured, and the mRNA and protein expressions of regulators in kidney were determined by PCR and immunoblotting, respectively. Treatment with salidroside increased bone calcium level and decreased urinary calcium excretion, consequently attenuating the deteriorations of trabecular bone in both OVX mice and diabetic mice. 25-Hydroxyvitamin D-24 hydroxylase expression was down-regulated and vitamin D receptor expression was up-regulated in kidney of both OVX mice and diabetic mice upon to salidroside treatment, which also inhibited the ovariectomy-induced decrease in expression of renal transcellular calcium transporters and the diabetes-induced enhancement in renal calcium-sensing receptor (CaSR) expression. Taken together, salidroside exerted osteoprotective effects by improving calcium homeostasis via regulating vitamin D metabolism and transcellular calcium transporters as well as modulating CaSR expression in kidney.
C1 [Chen, Xiang-Fan; Yang, Min; Song, Yan; Zhang, Yan] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China.
   [Li, Xiao-Li] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai 200093, Peoples R China.
C3 Nantong University; University of Shanghai for Science & Technology
RP Zhang, Y (corresponding author), Qixiu Rd 19, Nantong 226001, Jiangsu, Peoples R China.
EM riceandtiger@163.com
FU Natural Science Project of Nantong Science and Technology Board
   [MS12016037]; Jiangsu Province
FX This work was supported in part by specially invited professor program
   of Jiangsu Province, and Natural Science Project of Nantong Science and
   Technology Board (MS12016037).
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NR 36
TC 29
Z9 34
U1 0
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JAN 15
PY 2018
VL 819
BP 281
EP 288
DI 10.1016/j.ejphar.2017.12.025
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FS2SQ
UT WOS:000419629200033
PM 29242120
DA 2026-05-27
ER

PT J
AU Zhang, XR
   Fu, XJ
   Zhu, DS
   Zhang, CZ
   Hou, S
   Li, M
   Yang, XH
AF Zhang, Xin-ru
   Fu, Xiu-juan
   Zhu, Da-sheng
   Zhang, Chao-zai
   Hou, Shi
   Li, Min
   Yang, Xiao-hong
TI Salidroside-regulated lipid metabolism with down-regulation of miR-370
   in type 2 diabetic mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Type 2 diabetes; Primary hepatocytes; Lipid metabolic disorder
ID INSULIN-RESISTANCE; MICRORNAS; EXTRACT
AB Salidroside is known for its pharmacological properties and in particular its antioxidation effects. In recent years, it has been recognized that salidroside plays an important role in treating diabetes. Accumulated evidence suggests that microRNAs may be involved in diabetic lipid disorders. We investigated how salidroside regulates lipid metabolism through miR-370 in vivo and in vitro. After 4 weeks of a high-fat diet, and intraperitoneal injection of streptozotocin (100 mg/kg), type 2 diabetes was induced in male C56BL/61 mice. After 4 weeks, mice with fasting blood glucose levels above 7.8 mmol/l were divided into five groups: those with diabetes mellitus, and those treated with 40 mg/kg, 80 mg/kg, and 160 mg/kg salidroside, and metformin (480 mg/kg), for a further 4 weeks. The hypoglycemic effects of salidroside were consistently demonstrated when measuring fasting blood glucose levels, observing insulin-sensitizing effects, and testing oral glucose tolerance. In addition to this, the expressions of miR370, and related lipid protein expression in primary hepatocytes, were examined in primary type 2 diabetic mice. The present study has shown that the expression levels of miR-370, SREBP-1 and FAS-1 were significantly elevated in the liver of type 2 diabetic mice. In contrast, the elevated expression levels were reversed by salidroside. The addition of salidroside attenuated the effect of miR-370, and reduced the expression of these lipid metabolism proteins in primary hepatocytes. These findings demonstrate that salidroside can directly decrease the expression of miR-370 in type 2 diabetic mice, and particularly in primary hepatocytes, affecting lipid metabolism in the liver. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Zhang, Xin-ru; Zhang, Chao-zai; Hou, Shi; Yang, Xiao-hong] Jilin Univ, Coll Pharm, Dept Med Chem, Changchun 130023, Jilin, Peoples R China.
   [Zhang, Xin-ru; Fu, Xiu-juan; Zhu, Da-sheng] Jilin Univ, Hosp Norman Bethune 2, Dept Pharm, Changchun 130023, Jilin, Peoples R China.
   [Li, Min] Nongken Mudanjiang Adm Ctr Hosp, Dept Pharm, Mudanjiang, Heilongjiang, Peoples R China.
C3 Jilin University; Jilin University
RP Yang, XH (corresponding author), Jilin Univ, Coll Pharm, 1163 Xinmin St, Changchun 130021, Peoples R China.
EM xiaohongyang88@126.com
RI Li, Min/F-8032-2011; zhang, xinru/GZK-8155-2022
FU Jilin University; Department of Pharmacy at the Second Hospital Norman
   Bethune, Jilin University [3R214Y093429]
FX This work was supported by Jilin University and the Department of
   Pharmacy at the Second Hospital Norman Bethune, Jilin University
   (3R214Y093429).
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PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 15
PY 2016
VL 779
BP 46
EP 52
DI 10.1016/j.ejphar.2016.03.011
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DI8TR
UT WOS:000373775300006
PM 26948318
DA 2026-05-27
ER

PT J
AU Tian, Z
   Li, Y
   Wang, G
   Wang, J
   Zhang, Y
AF Tian, Z.
   Li, Yu
   Wang, G.
   Wang, J.
   Zhang, Ye
TI Therapeutic Effects of Salidroside on Cognitive Ability in Rats with
   Experimental Vascular Dementia
SO BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE vascular dementia; salidroside; oxidative stress; apoptosis; cognitive
   functions
ID OXIDATIVE STRESS; ALZHEIMERS-DISEASE
AB We examined the effects of salidroside on cognition in rats with vascular dementia and explored the mechanisms of its neuroprotective effects. Sprague-Dawley rats (n=60) were randomly subdivided into 3 equal groups: controls, untreated rats with vascular dementia, and rats with vascular dementia treated with salidroside (30 mg/kg for 8 weeks). Vascular dementia was provoked by bilateral occlusion of the common carotid arteries. The cognitive function was tested in the Morris water maze. Oxidation stress was assessed by the levels of superoxide dismutase and malondialdehyde assayed with standard biochemical kits. Expressions of proteins p38, p-p38, and caspase-3 were assessed by Western blotting. In untreated rats with vascular dementia, the cognitive function degraded in parallel with a decrease in superoxide dismutase, malondialdehyde accumulation, and activation the expression of p-p38 and caspase-3. Salidroside treatment significantly improved the cognitive functions in rats with vascular dementia and diminished adverse shifts in the levels of superoxide dismutase and malondialdehyde as well as the changes in the expression of p-p38 and caspase-3 in comparison with similar changes in untreated rats. Moreover, salidroside improved spatial learning and memory in rats with vascular dementia. The therapeutic effect of salidroside is probably based on its antioxidant effects and inhibition of caspase-3-mediated apoptosis via suppression of p38 MAPK signaling pathway.
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C3 North China University of Science & Technology; Taizhou University
RP Tian, Z (corresponding author), Tianjin Huanhu Hosp, Dept Neurol, 6 Jizhao Rd, Tianjin, Peoples R China.
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NR 12
TC 7
Z9 9
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0007-4888
EI 1573-8221
J9 B EXP BIOL MED+
JI Bull. Exp. Biol. Med.
PD MAY
PY 2020
VL 169
IS 1
BP 35
EP 39
DI 10.1007/s10517-020-04818-5
EA JUN 2020
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LW6LO
UT WOS:000537387900013
PM 32488778
DA 2026-05-27
ER

PT J
AU Xiong, YL
   Wang, YM
   Xiong, YL
   Gao, W
   Teng, LH
AF Xiong, Yanlei
   Wang, Yueming
   Xiong, Yanlian
   Gao, Wei
   Teng, Lianghong
TI Salidroside alleviated hypoxia-induced liver injury by inhibiting
   endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Salidroside; Hypoxia; Apoptosis; Endoplasmic reticulum stress; IRE1
   alpha
ID PROTEIN-KINASE PATHWAY; ER; CYTOTOXICITY; MECHANISMS; AUTOPHAGY; JNK
AB Endoplasmic reticulum (ER) stress and subsequent apoptosis played vital role in liver injury and dysfunction. The aim of this study was to investigate the protective effect and mechanism of salidroside on hypoxia induced liver injury both in vivo and in vitro. Male SD rats were exposed to hypobaric chamber to simulate high altitude hypoxia model. High altitude hypoxia led to significant liver injury and apoptosis, increased the expression levels of p-JNK, BAX and ER stress markers. Salidroside treatment significantly inhibited hypoxia induced ER stress by decreasing the protein expression of glucose-regulated protein 78 (GRP78), CCAAT/enhancer binding protein homologous protein (CHOP) and phosphorylated inositol-requiring enzyme 1 alpha (p-IRE1 alpha). In addition, salidroside treatment also restrained the ER stress-mediated apoptotic pathway, as indicated by decreased pro-apoptotic proteins p-JNK, TRAF2, BAX, and cleaved caspase 9 and caspase 12, as well as upregulation of Bcl-2. Furthermore, in vitro study found that blocking IRE1 alpha pathway using specific inhibitor STF-083010 subsequently reversed the protective effect of salidroside on liver apoptosis. Taken together, our findings revealed that salidroside exerts protective effects against hypoxia induced liver injury through inhibiting ER stress mediated apoptosis via IRE1 alpha/JNK pathway. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Xiong, Yanlei; Gao, Wei; Teng, Lianghong] Capital Med Univ, Xuanwu Hosp, Dept Pathol, 45 Changchun St, Beijing 100053, Peoples R China.
   [Xiong, Yanlei] Chinese Acad Med Sci CAMS, Peking Union Med Coll PUMC, Sch Basic Med, Dept Pathophysiol,Inst Basic Med Sci, Beijing, Peoples R China.
   [Wang, Yueming; Xiong, Yanlian] Binzhou Med Univ, Sch Basic Med, Dept Anat, Yantai, Peoples R China.
C3 Capital Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College; Shandong Medical &
   Pharmaceutical University
RP Teng, LH (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Pathol, 45 Changchun St, Beijing 100053, Peoples R China.
EM tenglianghong@163.com
OI Xiong, Yanlei/0000-0001-8555-494X; Wang, Yueming/0000-0003-1375-8737;
   Xiong, Yanlian/0000-0001-5178-8932
FU National Natural Science Foundation of China [81700760]; Natural Science
   Foundation of Shandong Province [ZR2018QH002]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 81700760) and Natural Science Foundation of Shandong
   Province (grant number ZR2018QH002).
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NR 32
TC 37
Z9 47
U1 0
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 20
PY 2020
VL 529
IS 2
BP 335
EP 340
DI 10.1016/j.bbrc.2020.06.036
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA MP0AC
UT WOS:000551875700033
PM 32703432
DA 2026-05-27
ER

PT J
AU Shati, AA
   Alfaifi, MY
AF Shati, Ali A.
   Alfaifi, Mohammad Y.
TI Salidroside protects against diabetes mellitus-induced kidney injury and
   renal fibrosis by attenuating TGF-β1 and Wnt1/3a/β-catenin signalling
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE diabetes mellitus; GS3K beta; kidney; rats; Salidroside; TGF-beta 1;
   Wnt/beta-catenin
ID TO-MESENCHYMAL TRANSITION; OXIDATIVE STRESS; IN-VIVO; NEPHROPATHY;
   PATHWAY; EXPRESSION; MICE; PATHOGENESIS; ACTIVATION; MECHANISMS
AB This study evaluated if the nephroprotective effect of Salidroside in type 1 diabetes mellitus (T1DM) involves modulation of Wnt/beta-catenin signalling pathways. Control or Streptozotocin (STZ, 50 mg/kg, iv)-induced T1DM adult male Wister rats were treated with the vehicle and Salidroside (100 mg/kg, orally) for 8 weeks daily. As compared to T1DM-induced rats, Salidroside improved kidney structure, reduced urinary protein and albumin level, increased creatinine clearance, and suppressed renal fibrosis. It also decreased mRNA and protein levels of Wnt1, Wnt3, and TGF-beta 1, phosphorylation of Smad-3, total and nuclear levels of beta-catenin, and levels and activities of cleaved caspase-3. Concomitantly, Salidroside significantly increased the levels of p-beta-catenin (Ser(33/37)/Thr(41)) and suppressed protein levels of Axin-2, fibronectin, and, mRNA and protein levels of collagen IIIa, the main targets of beta-catenin. In both control and T1DM rats, Salidroside significantly lowered fasting glucose levels and reduced renal levels of reactive oxygen species (ROS) p-and GS3K beta (Ser9) but significantly increased levels of SOD and GSH. In conclusion, Salidroside protected the kidney of rats against T1DM-induced injury and fibrosis by activating GS3K beta-induced inhibition of Wnt1/Wnt3a beta-catenin. This was associated with hypoglycaemic and antioxidant effects.
C1 [Shati, Ali A.; Alfaifi, Mohammad Y.] King Khalid Univ, Coll Sci, Dept Biol, Abha, Saudi Arabia.
C3 King Khalid University
RP Shati, AA (corresponding author), King Khalid Univ, Coll Sci, Dept Biol, Abha, Saudi Arabia.
EM aaalshati@kku.edu.sa
RI Shati, Ali/J-8491-2012; Alfaifi, Mohammad/AIB-4544-2022
FU King Khalid University, Abha, Saudi Arabia [RGP1/1440/143]
FX This study was funded by the Deanship of Scientific Research at King
   Khalid University, Abha, Saudi Arabia (grant number RGP1/1440/143).
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Z9 32
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD OCT
PY 2020
VL 47
IS 10
BP 1692
EP 1704
DI 10.1111/1440-1681.13355
EA JUN 2020
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA NJ8XY
UT WOS:000539805000001
PM 32472701
DA 2026-05-27
ER

PT J
AU Li, S
   Wang, BS
AF Li, Song
   Wang, Bishi
TI Anti-Inflammatory, Anti-Colitis, and Antioxidant Effects of Salidroside
   against Dextran Sodium Sulfate Induced Ulcerative Colitis in Rats via
   Inhibition of NF-κB-INOS-No and TLR4-NF-κB Signaling Pathways
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE HO-1/Nrf2; Inflammation; Oxidative stress; Salidroside; TLR4/NF-kappa B;
   Ulcerative colitis
ID OXIDATIVE STRESS; MECHANISM; INFLAMMATION
AB Ulcerative colitis is a persistent inflammatory bowel disorder that predominantly impacts the mucosal lining of the rectum and colon. Targeting inflammatory reactions serves a preventative function in the management of ulcerative colitis. Salidroside has already exhibited an anti-inflammatory effect against various diseases. The current investigation demonstrated the protective effect of salidroside against dextran sodium sulfate (DSS)-induced UC in rats. 3% DSS was dissolved in the drinking water and administered to the rats for induction of UC in rats and rats were orally administered the salidroside and sulfasalazine for 7 days. The body weight, macroscopic study, organ weight, water intake, food intake, antioxidant, apoptosis, cytokines and inflammatory parameters were estimated. The disease activity index was measured in all groups. The level of VCAM-1, ICAM-1, HO-1 and Nrf(2) were estimated. The mRNA expressions were estimated in the colon tissue. Histopathological study of the colon tissue was also performed. Salidroside treatment remarkably improved the body weight and altered the organ weight. Salidroside treatment significantly (p < 0.001) suppressed the DAI score along with alteration of oxidative stress (MDA, SOD, CAT, GSH), cytokines (TNF-alpha, IL-1, 1 beta, 6, 10, 18), inflammatory parameters (TGF-beta, PGE(2), COX-2, NF-kappa B, iNOS), apoptosis (Bcl-2, Bcl-2:Bax ratio, Bax, caspase-3) parameters. Salidroside treatment suppressed the level of VCAM-1, NO, ICAM-1, MPO and upgraded the level of Nrf(2) and HO-1. Salidroside treatment altered the mRNA expression of Ocln, ASC, TNF-alpha, MCP-1, ZO-1, IFN-gamma, IL-1 beta, IL-6, iNOS, COX-2, TGF-beta and TLR4. The results clearly demonstrated that salidroside may exert Anti-inflammatory, anti-colitis, and antioxidant effects by altering the expression of key genes involved in the NF-kappa B-iNOS-NO and TLR4-NF-kappa B signaling pathways.
C1 [Li, Song] Jinan Third People's Hosp, Dept Anorectal, Jinan, Peoples R China.
   [Wang, Bishi] Shandong First Med Univ, Hosp Ward 1 Colorectal Surg, Shandong Canc Hosp, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Wang, BS (corresponding author), Shandong First Med Univ, Hosp Ward 1 Colorectal Surg, Shandong Canc Hosp, Jinan, Shandong, Peoples R China.
EM wangbishi1521@outlook.com
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NR 40
TC 1
Z9 1
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD SEP 30
PY 2025
VL 39
IS 10
AR e70520
DI 10.1002/jbt.70520
PG 12
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA 8CP3R
UT WOS:001585466200001
PM 41024662
DA 2026-05-27
ER

PT J
AU Li, B
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AF Li, Bo
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   Xin, Rui
TI Salidroside decrease expression of hypoxia-inducible factor-1α in
   cultured human lung cancer cells
SO AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE Salidroside; A549; HIF-alpha; QPCR; NSCLC; Western-bolt
ID RHODIOLA-ROSEA; EXTRACT; APOPTOSIS; STRESS; LIVER; DRUG
AB Salidroside is a active constituent of traditional herbal medicine Rhodiola rosea, responsible for the neuroprotective, antidepressant, anxiolytic and anti-tumor actions. However, the mechanism of its anticancer effect is unclear as there have little molecular studies regarding cell migration, invasion, cell cycle, induction of apoptosis in healthy and cancerous cells. Hypoxia-inducible factor-1 alpha (HIF-alpha) plays an important role in tumor growth, angiogenesis and lymph node metastasis of non-small cell lung cancer (NSCLC). Thus, the present study aims to investigate changes from hypoxia-inducible factor-1 alpha (HIF-alpha) of NSCLC A549 cell after using salidroside treatment by quantitative polymerase chain reaction (QPCR) and western-bolt on mRNA level and protein level, respectively. The results demonstrated that HIF-alpha was significantly down-regulated in salidroside treatment group in comparison to the A549 group on mRNA level ( P < 0.05), on protein level, HIF-alpha was also highly decreased in salidroside treatment group in comparison to control group. The present study provides improvement in understanding the molecular pathogenic mechanism of lung cancer and development salidroside as effective anticancer drugs.
C1 [Li, Bo; Xin, Rui] Jilin Univ, Affiliated Hosp 2, Dept Radiol, Changchun 130021, Jilin, Peoples R China.
   [Qu, Danhua] Jilin Univ, Affiliated Hosp 2, Dept Resp Med, Changchun 130021, Jilin, Peoples R China.
   [Xin, Rui] Jilin Univ, MH Radiobiol Res Unit, Sch Publ Hlth, Changchun 130021, Jilin, Peoples R China.
   [Wang, Zhongan] Capital Med Univ, Shijitan Affiliated Hosp, Beijing, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Capital Medical
   University
RP Xin, R (corresponding author), Jilin Univ, Affiliated Hosp 2, Dept Radiol, Changchun 130021, Jilin, Peoples R China.
EM xinrui318@yahoo.cn
FU Departments of Radiology, The Second Affiliated Hospital of Jilin
   University of students
FX This research was supported by Departments of Radiology, The Second
   Affiliated Hospital of Jilin University of students.
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NR 23
TC 2
Z9 2
U1 0
U2 42
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0816
J9 AFR J PHARM PHARMACO
JI Afr. J. Pharm. Pharmacol.
PD SEP
PY 2012
VL 6
IS 34
BP 2526
EP 2530
DI 10.5897/AJPP12.403
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 033PJ
UT WOS:000310810000004
OA gold
DA 2026-05-27
ER

PT J
AU Yang, XP
   Wang, FF
   Yan, J
   Ma, K
   Mao, DB
AF Yang, Xue-Peng
   Wang, Fang-Fang
   Yan, Ji
   Ma, Ke
   Mao, Duo-Bin
TI A new family-3 glycoside hydrolase from Penicillium oxalicum BL
   3005 catalyzing tyrosol glucosylation to form salidroside
SO BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
LA English
DT Article
DE beta-glucosidase; transglycosylation; Penicillium oxalicum; cellobiose;
   salidroside
ID ENZYMATIC-SYNTHESIS; BETA-GLUCOSIDASE; RHODIOLA-ROSEA;
   TRANSGLYCOSYLATION; OLIGOSACCHARIDES; IDENTIFICATION; PURIFICATION;
   EXTRACT; CLONING
AB A glycoside hydrolase from Penicillium oxalicum BL 3005 was purified to apparent homogeneity. Its molecular mass was estimated to be 90 kDa by SDS-PAGE. The enzyme was identified to be a new member of family-3 by peptide sequence. High transglycosylation activity was found in the hydrolytic reaction of cellobiose. In the reaction, salidroside (4-hydroxyphenethyl O--d-glucopyranoside) was formed by adding tyrosol as the glycosyl acceptor. The optimum reaction pH and temperature were pH 6.5 and 55 degrees C, respectively. The maximum yield of salidroside was almost 20 g/L. These results indicated that the -glucosidase of P. oxalicum can be considered as a very promising catalyst for the synthesis of salidroside. (C) 2016 International Union of Biochemistry and Molecular Biology, Inc.
C1 [Yang, Xue-Peng; Wang, Fang-Fang; Yan, Ji; Ma, Ke; Mao, Duo-Bin] Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou, Peoples R China.
   [Yang, Xue-Peng; Wang, Fang-Fang; Yan, Ji; Ma, Ke; Mao, Duo-Bin] Henan Prov Collaborat Innovat Ctr Food Prod & Saf, Zhengzhou, Henan, Peoples R China.
C3 Zhengzhou University of Light Industry
RP Yang, XP (corresponding author), Zhengzhou Univ Light Ind, Sch Food Sci & Biol Engn, Zhengzhou, Henan, Peoples R China.
EM yangxuepeng@zzuli.edu.cn
FU National Natural Science Foundation of China [21476217]
FX This work was partly supported by the National Natural Science
   Foundation of China (grant no. 21476217). The authors declare no
   conflict of interest.
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Z9 6
U1 3
U2 60
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-4513
EI 1470-8744
J9 BIOTECHNOL APPL BIOC
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BP 525
EP 531
DI 10.1002/bab.1508
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA FE3PA
UT WOS:000408126800009
PM 27222303
DA 2026-05-27
ER

PT J
AU Li, L
   Yao, WL
AF Li, Li
   Yao, Wenlong
TI The Therapeutic Potential of Salidroside for Parkinson's Disease
SO PLANTA MEDICA
LA English
DT Review
DE Dopamine; Parkinson's disease; Sedum roseum; Crassulaceae; salidroside
ID ALPHA-SYNUCLEIN; SCHWANN-CELLS; MITOCHONDRIAL-FUNCTION; DOPAMINE
   TRANSPORTER; STEM-CELLS; IN-VITRO; ASTROCYTES; PINK1; NERVE; MICROGLIA
AB Parkinson's disease (PD), a neurological disorder, is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. Its incidence increases with age. Salidroside, a phenolic compound extracted from Sedum roseum , reportedly has multiple biological and pharmacological activities in the nervous system. However, its effects on PD remain unclear. In this review, we summarize the effects of salidroside on PD with regard to DA metabolism, neuronal protection, and glial activation. In addition, we summarize the susceptibility genes and their underlying mechanisms related to antioxidation, inflammation, and autophagy by regulating mitochondrial function, ubiquitin, and multiple signaling pathways involving NF- kappa B, mTOR, and PI3K/Akt. Although recent studies were based on animal and cellular experiments, this review provides evidence for further clinical utilization of salidroside for PD.
C1 [Li, Li] Hubei Univ Chinese Med, Dept Physiol, 16 West Huangjiahu Rd, Wuhan 430065, Peoples R China.
   [Yao, Wenlong] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan, Peoples R China.
C3 Hubei University of Chinese Medicine; Huazhong University of Science &
   Technology
RP Li, L (corresponding author), Hubei Univ Chinese Med, Dept Physiol, 16 West Huangjiahu Rd, Wuhan 430065, Peoples R China.
EM lily81630@hbtcm.edu.cn
RI Yao, Wenlong/JXN-3011-2024
FU Science and Technology Research Project of the Hubei Provincial
   Department of Education, China [Q20162004]
FX The authors appreciate colleagues in the Department of Physiology, Hubei
   University of Chinese Medicine. This work was supported by the Science
   and Technology Research Project of the Hubei Provincial Department of
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NR 114
TC 8
Z9 8
U1 2
U2 19
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD APR
PY 2023
VL 89
IS 04
BP 353
EP 363
DI 10.1055/a-1948-3179
EA NOV 2022
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA C3LC0
UT WOS:000890903200001
PM 36130710
DA 2026-05-27
ER

PT J
AU Wei, SM
   Huang, YM
   Qin, ZQ
AF Wei, Si-Ming
   Huang, Yu-Min
   Qin, Zhi-Quan
TI Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion
   Injury in Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID TORSION-DETORSION INJURY; ISCHEMIA/REPERFUSION INJURY;
   SUPEROXIDE-DISMUTASE; MOLECULAR-MECHANISMS; TORSION/DETORSION;
   ANTIOXIDANTS; TESTES; CHILDREN; EXTRACT; PATHWAY
AB Testicular torsion-detorsion results in testicular ischemia-reperfusion injury, which is associated with overgeneration of reactive oxygen species. Salidroside, a major bioactive ingredient extracted from Rhodiola rosea, has strong antioxidant activity. The purpose of this study was to examine the effect of salidroside on testicular ischemia-reperfusion injury. Sixty rats were randomly separated into 3 experimental groups: group A = sham-operated control; group B = testicular ischemia-reperfusion; and group C = testicular ischemia-reperfusion treated with salidroside. The rats in the sham-operated control group received all surgical procedures except testicular torsion-detorsion. The testicular ischemia-reperfusion group underwent 2 hours of left testicular torsion followed by detorsion. The rats in the salidroside-treated group received the same surgical procedure as in testicular ischemia-reperfusion group, but salidroside was injected intraperitoneally at reperfusion. Testicular malondialdehyde content (a reliable index of reactive oxygen species) and protein expression of superoxide dismutase and catalase which are primary antioxidant enzymes in testes were measured at 4 hours after reperfusion. Testicular spermatogenesis was evaluated at 3 months after reperfusion. The malondialdehyde content increased significantly, while superoxide dismutase and catalase protein expression and testicular spermatogenesis reduced significantly in ipsilateral testes of testicular ischemia-reperfusion group, as compared with sham-operated control group. Therapy with salidroside significantly reduced malondialdehyde content and significantly enhanced superoxide dismutase and catalase protein expression and spermatogenesis in ipsilateral testes, as compared with testicular ischemia-reperfusion group. The present findings indicate that treatment with salidroside ameliorates testicular ischemia-reperfusion injury by reducing reactive oxygen species level by upregulating superoxide dismutase and catalase protein expression.
C1 [Wei, Si-Ming] Zhejiang Shuren Univ, Shulan Int Med Coll, Hangzhou 310015, Zhejiang, Peoples R China.
   [Wei, Si-Ming] Zhejiang Chinese Med Univ, Sch Nursing, Hangzhou 310053, Zhejiang, Peoples R China.
   [Huang, Yu-Min] Zhejiang Univ, Coll Educ, Dept Sport Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Qin, Zhi-Quan] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Canc Ctr,Dept Med Oncol, Hangzhou 310014, Zhejiang, Peoples R China.
C3 Zhejiang Shuren University; Zhejiang Chinese Medical University;
   Zhejiang University; Hangzhou Medical College; Zhejiang Provincial
   People's Hospital
RP Qin, ZQ (corresponding author), Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Canc Ctr,Dept Med Oncol, Hangzhou 310014, Zhejiang, Peoples R China.
EM wsm1971@hotmail.com; hym0310@hotmail.com; qinzhiquan66@hotmail.com
FU Zhejiang Provincial Natural Science Foundation of China [LY19H040001]
FX AcknowledgmentsThis research was supported by the Zhejiang Provincial
   Natural Science Foundation of China under grant no. LY19H040001.
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NR 92
TC 21
Z9 21
U1 1
U2 37
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAY 11
PY 2022
VL 2022
AR 8069152
DI 10.1155/2022/8069152
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1T8IP
UT WOS:000804969900003
PM 35602096
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhou, F
   Huang, WS
   Li, MQ
   Zhong, YH
   Wang, MM
   Lu, BY
AF Zhou, Fei
   Huang, Weisu
   Li, Maiquan
   Zhong, Yongheng
   Wang, Mengmeng
   Lu, Baiyi
TI Bioaccessibility and Absorption Mechanism of Phenylethanoid Glycosides
   Using Simulated Digestion/Caco-2 Intestinal Cell Models
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE total phenylethanoid glycoside; acteoside; salidroside;
   bioaccessibility; absorption mechanism
ID FRAGRANS LOUR. FLOWERS; IN-VITRO; CACO-2 CELLS; PHENOLIC-COMPOUNDS; DRUG
   ABSORPTION; PC12 CELLS; SALIDROSIDE; BIOAVAILABILITY; VERBASCOSIDE;
   TRANSPORT
AB Acteoside and salidroside are major phenylethanoid glycosides (PhGs) in Osmanthus fragrans Lour. flowers with extensive pharmacological activities and poor oral bioavailability. The absorption mechanisms of these two compounds remain unclear. This study aimed to investigate the bioaccessibility of these compounds using an in vitro gastrointestinal digestion model and to examine the absorption and transport mechanisms of PhGs using the Caco-2 cell model. The in vitro digestion model revealed that the bioaccessibility of salidroside (98.7 +/- 1.35%) was higher than that of acteoside (50.1 +/- 3.04%), and the superior bioaccessibility of salidroside can be attributed to its stability. The absorption percentages of total phenylethanoid glycoside, salidroside, and acteoside were 1.42-1.54%, 2.10-2.68%, and 0.461-0.698% in the Caco-2 model, respectively. Salidroside permeated Caco-2 cell monolayers through passive diffusion. At the concentration of 200 mu g/mL, the apparent permeability (P-app) of salidroside in the basolateral (BL)-to-apical (AP) direction was 23.7 +/- 1.33 x 10(-7) cm/s, which was 1.09-fold of that in the AP-to-BL direction (21.7 +/- 1.38 X 10(-7) cm/s). Acteoside was poorly absorbed with low P-app (AP to BL) (4.75 +/- 0.251 X 10(-7) cm/s), and its permeation mechanism was passive diffusion with active efflux mediated by P-glycoprotein (P-gp). This study clarified the bioaccessibility, absorption, and transport mechanisms of PhGs. It also demonstrated that the low bioavailability of acteoside might be attributed to its poor bioaccessibility, low absorption, and P-gp efflux transporter.
C1 [Zhou, Fei; Li, Maiquan; Zhong, Yongheng; Wang, Mengmeng; Lu, Baiyi] Zhejiang Univ, Natl Engn Lab Intelligent Food Technol & Equipmen, Key Lab Agro Prod Postharvest Handling,Fuli Inst, Key Lab Agroprod Nutr Evaluat,Minist Agr,Key Lab, Hangzhou 310058, Zhejiang, Peoples R China.
   [Huang, Weisu] Zhejiang Econ & Trade Polytech, Dept Appl Technol, Hangzhou 310018, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Lu, BY (corresponding author), Zhejiang Univ, Natl Engn Lab Intelligent Food Technol & Equipmen, Key Lab Agro Prod Postharvest Handling,Fuli Inst, Key Lab Agroprod Nutr Evaluat,Minist Agr,Key Lab, Hangzhou 310058, Zhejiang, Peoples R China.
EM bylu@zju.edu.cn
RI ; Yang, Bowen/KWV-0501-2024
OI Wang, Mengmeng/0000-0003-0856-4831; 
FU National Major R&D Program of China [2017YFD0400200]; Zhejiang
   Provincial Natural Science Foundation of China [R15C200002]; Special
   Project of Agricultural Product Quality Safety Risk Assessment, Ministry
   of Agriculture, China [GJFP2018015]
FX This study was supported by the National Major R&D Program of China (No.
   2017YFD0400200), the Zhejiang Provincial Natural Science Foundation of
   China (No. R15C200002), and the Special Project of Agricultural Product
   Quality Safety Risk Assessment (No. GJFP2018015), Ministry of
   Agriculture, China.
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SN 0021-8561
EI 1520-5118
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IS 18
BP 4630
EP 4637
DI 10.1021/acs.jafc.8b01307
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GF6RJ
UT WOS:000432094900007
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TI Salidroside Delays Cellular Senescence by Stimulating Mitochondrial
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LA English
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ID PROTEIN-KINASE ACTIVITY; RAT SKELETAL-MUSCLE; CALORIE RESTRICTION;
   GLUCOSE-UPTAKE; RESVERATROL; EXPRESSION; CELLS; RECEPTOR; SIRT1; MODEL
AB Calorie restriction (CR) is a nongenetic intervention with a robust effect on delaying aging in mammals and other organisms. A mild stimulation on mitochondrial biogenesis induced by CR seems to be an important action mode for its benefits. Here, we reported that a component isolated from Rhodiola rosea L., salidroside, delays replicative senescence in human fibroblasts, which is related to its stimulation on mitochondrial biogenesis by activating SIRT1 partly resulted from inhibition on miR-22. Salidroside increased the mitochondrial mass that accompanied an increment of the key regulators of mitochondrial biogenesis including PGC-1 alpha, NRF-1, and TFAM and reversed the mitochondrial dysfunction in presenescent 50PD cells, showing a comparable effect to that of resveratrol. SIRT1 is involved in the inducement of mitochondrial biogenesis by salidroside. The declined expression of SIRT1 in 50PD cells compared with the young 30PD cells was prevented upon salidroside treatment. In addition, pretreatment of EX-527, a selective SIRT1 inhibitor, could block the increased mitochondrial mass and decreased ROS production induced by salidroside in 50PD cells, resulting in an accelerated cellular senescence. We further found that salidroside reversed the elevated miR-22 expression in presenescent cells according to a miRNA array analysis and a subsequent qPCR validation. Enforced miR-22 expression by using a Pre-miR-22 lentiviral construct induced the young fibroblasts (30PD) into a senescence state, accompanied with increased senescence-related molecules including p53, p21, p16, and decreased SIRT1 expression, a known target of miR-22. However, salidroside could partly impede the senescence progression induced by lenti-Pre-miR-22. Taken together, our data suggest that salidroside delays replicative senescence by stimulating mitochondrial biogenesis partly through a miR22/SIRT1 pathway, which enriches our current knowledge of a salidroside-mediated postpone senility effect and provides a new perspective on the antidecrepitude function of this naturally occurring compound in animals and humans.
C1 [Mao, Gen-Xiang; Xu, Xiao-Gang; Wang, San-Ying; Zhang, Jing; Su, Hui-Li; Chen, Sha-Sha; Xing, Wen-Min; Wang, Ya-Zhen; Dai, Ji-Huan; Wang, Guo-Fu; Yan, Jing] Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
   [Mao, Gen-Xiang; Xu, Xiao-Gang; Wang, San-Ying; Zhang, Jing; Su, Hui-Li; Chen, Sha-Sha; Xing, Wen-Min; Wang, Ya-Zhen; Dai, Ji-Huan; Wang, Guo-Fu; Yan, Jing] Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Dept Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
   [Li, Hui-Fen; Leng, Sean X.] Johns Hopkins Univ, Sch Med, Dept Med, Div Geriatr Med & Gerontol, Baltimore, MD 21224 USA.
   [Zhang, Zhong-Shan] Huzhou Univ, Dept Pharmacol, Huzhou 313000, Peoples R China.
C3 Johns Hopkins University; Huzhou University
RP Mao, GX; Yan, J (corresponding author), Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.; Mao, GX; Yan, J (corresponding author), Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Dept Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.; Leng, SX (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, Div Geriatr Med & Gerontol, Baltimore, MD 21224 USA.
EM maogenxiang@163.com; sleng1@jhmi.edu; zjicu@vip.163.com
RI wang, sanying/HIZ-7552-2022
OI wang, sanying/0000-0002-8172-876X; Xu, Xiaogang/0000-0003-4364-5856
FU National Natural Science Foundation of China [81771520, 31201040,
   31700307, 31702144]; Science Technology Department of Zhejiang Province
   [2016C34002]; Natural Science Foundation of Zhejiang Province
   [LQ16H020006]; Health Bureau of Zhejiang Province [WKJ2011-2-014,
   2015DTA001, 2015KYA001, 2019KY257, 2019RC091, 2019RC093, 2017KY188,
   2017KY189]; MMAAP Foundation
FX This study was supported by the National Natural Science Foundation of
   China (81771520, 31201040, 31700307, and 31702144), the Science
   Technology Department of Zhejiang Province (2016C34002), the Natural
   Science Foundation of Zhejiang Province (LQ16H020006), and funds from
   the Health Bureau of Zhejiang Province (WKJ2011-2-014, 2015DTA001,
   2015KYA001, 2019KY257, 2019RC091, 2019RC093, 2017KY188, and 2017KY189).
   Dr. Gen-Xiang Mao was an Irma and Paul Milstein Program for Senior
   Health fellow supported by the MMAAP Foundation
   (https://www.mmaapf.org/).
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NR 51
TC 36
Z9 45
U1 0
U2 34
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP 12
PY 2019
VL 2019
AR 5276096
DI 10.1155/2019/5276096
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JA4OW
UT WOS:000487809600001
PM 31612074
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Song, BC
   Huang, GR
   Xiong, Y
   Liu, JB
   Xu, LL
   Wang, ZN
   Li, G
   Lu, J
   Guan, S
AF Song, Bocui
   Huang, Guoren
   Xiong, Ying
   Liu, Jingbo
   Xu, Linli
   Wang, Zhenning
   Li, Gen
   Lu, Jing
   Guan, Shuang
TI Inhibitory Effects of Salidroside on Nitric Oxide and Prostaglandin
   E2 Production in Lipopolysaccharide-Stimulated RAW 264.7
   Macrophages
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE [Ca2+]i; COX-2; iNOS; NF-B; NO; PGE(2); salidroside
ID RHODIOLA-ROSEA L.; ACTIVATION; INFLAMMATION; EXPRESSION; EXTRACT;
   STRESS; MICE
AB The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E-2 (PGE(2)) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE(2) production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tested by Griess reagent. Inducible nitric oxidesynthase (iNOS) and COX-2 were determined by RT-PCR and Western blot analysis; IB and P-IB protein express were detected by Western blot analysis; cytosolic free Ca2+ ([Ca2+]i)was measured by a fluorescent microscope. The data showed salidroside inhibited LPS-induced NO and PGE(2) production and reduced iNOS and COX-2 protein expression in RAW 264.7 macrophages. Consistent with these observations, salidroside inhibited LPS-induced cytosolic free Ca2+ concentration ([Ca2+]i) elevation. In addition, we further investigated signal transduction mechanisms and found that the activation of NF-B was suppressed by salidroside in a dose-dependent manner. These results suggest that salidroside suppresses NO and PGE(2) production by inhibiting iNOS and COX-2 protein expression, level of [Ca2+]i, and activation of NF-B signal transduction pathway.
C1 [Song, Bocui; Xiong, Ying; Li, Gen; Lu, Jing; Guan, Shuang] Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis, Changchun 130062, Jilin, Peoples R China.
   [Huang, Guoren; Liu, Jingbo; Xu, Linli; Wang, Zhenning; Lu, Jing; Guan, Shuang] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Guan, S (corresponding author), Jilin Univ, Lab Nutr & Funct Food, Xian Rd 5333 Code, Changchun 130062, Jilin, Peoples R China.
EM gshuang1973@126.com
RI Guan, Shuang/JXN-9245-2024; Liu, Jingbo/PXW-9760-2026; Xiong,
   Yingzhu/LOR-2049-2024
FU National Nature Science Foundation of China [30972212]
FX This study was financed by the National Nature Science Foundation of
   China (No. 30972212).
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NR 22
TC 21
Z9 24
U1 0
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD NOV 1
PY 2013
VL 16
IS 11
BP 997
EP 1003
DI 10.1089/jmf.2012.2473
PG 7
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 252RG
UT WOS:000327026500006
PM 24180550
DA 2026-05-27
ER

PT J
AU Sun, L
   Dou, FF
   Chen, JL
   Chi, HY
   Xing, SL
   Liu, T
   Sun, SW
   Chen, C
AF Sun, Lin
   Dou, Fangfang
   Chen, Jiulin
   Chi, Huiying
   Xing, Sanli
   Liu, Te
   Sun, Shenwei
   Chen, Chuan
TI Salidroside slows the progression of EA.hy926 cell senescence by
   regulating the cell cycle in an atherosclerosis model
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; aging; atherosclerosis; endothelial cell; lipid deposition
ID OXIDATIVE STRESS; PATHWAY ACTIVATION; ENDOTHELIAL-CELLS; PROTEINS;
   P66(SHC); REVERSAL; DISEASE; GLUCOSE; KINASE; MICE
AB Aging is the major risk factor for diseases of the cardiovascular system, such as coronary atherosclerotic heart disease, but little is known about the relationship between atherosclerosis (AS) and age-related declines in vascular structure and function. Here, we used histological analyses in combination with molecular biology techniques to show that lipid deposition in endothelial cell was accompanied by aging and growth arrest. Endothelial cell senescence is sufficient to cause AS; however, we found that salidroside reduced intracellular lipid deposition, slowed the progression of endothelial cell senescence and inhibited the expression of the senescence-related molecules and phosphorylated the retinoblastoma (Rb) protein. Further study confirmed that salidroside increased the percent of S phase cells in oxidized low-density lipoprotein (ox-LDL)-treated endothelial cells. Collectively, vascular endothelial cell function declined with age and AS, and our data suggested that salidroside prevented ox-LDL-treated endothelial cell senescence by promoting cell cycle progression from G0/G1 phase to S phase via Rb phosphorylation. We demonstrated for the first time the complex interactions between AS and endothelial cell senescence, and we believe that salidroside represents a promising therapy for senescence-related AS.
C1 [Sun, Lin; Dou, Fangfang; Chen, Jiulin; Chi, Huiying; Xing, Sanli; Liu, Te; Chen, Chuan] Shanghai Univ Tradit Chinese Med, Shanghai Geriatr Inst Chinese Med, Basic Res Dept, Bldg C,365 South Xiangyang Rd, Shanghai 200031, Peoples R China.
   [Sun, Shenwei] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Internal Med Tradit Chinese Med, 725 South Wanping Rd, Shanghai 200031, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Chen, C (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Geriatr Inst Chinese Med, Basic Res Dept, Bldg C,365 South Xiangyang Rd, Shanghai 200031, Peoples R China.; Sun, SW (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Internal Med Tradit Chinese Med, 725 South Wanping Rd, Shanghai 200031, Peoples R China.
EM sunsw55@hotmail.com; ch9453@126.com
FU Natural Science Foundation of China [81373706, 81503626]; Shanghai
   Health Bureau Youth Fund [201540254]
FX We would like to thank Wengong Wang (Peking University Health Science
   Center) for his helpful comments on the manuscript. The present study
   was supported by grants from Natural Science Foundation of China
   (program no. 81373706, 81503626) and from the Shanghai Health Bureau
   Youth Fund (program no. 201540254).
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NR 32
TC 30
Z9 34
U1 1
U2 24
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2018
VL 17
IS 1
BP 257
EP 263
DI 10.3892/mmr.2017.7872
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FT8WG
UT WOS:000423433300032
PM 29115447
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, J
   Kasim, V
   Xie, YD
   Huang, C
   Sisjayawan, J
   Ariyanti, AD
   Yan, XS
   Wu, XY
   Liu, CP
   Yang, L
   Miyagishi, M
   Wu, SR
AF Zhang, Jing
   Kasim, Vivi
   Xie, Yu-Dan
   Huang, Can
   Sisjayawan, Julita
   Ariyanti, Agnes Dwi
   Yan, Xue-Song
   Wu, Xiao-Yan
   Liu, Cai-Ping
   Yang, Li
   Miyagishi, Makoto
   Wu, Shou-Rong
TI Inhibition of PHD3 by salidroside promotes neovascularization through
   cell-cell communications mediated by muscle-secreted angiogenic factors
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INDUCIBLE FACTOR-I; PERIPHERAL ARTERIAL-DISEASE; FIBROBLAST GROWTH
   FACTOR-2; THERAPEUTIC ANGIOGENESIS; HINDLIMB ISCHEMIA; PDGF-BB; PROLYL
   HYDROXYLASES; HYPOXIA; HIF-1-ALPHA; ALPHA
AB Therapeutic angiogenesis has been considered as a potential strategy for treating peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug-based treatment is currently available. Here we showed that intramuscular administration of salidroside, an active compound of Chinese herb Rhodiola, could robustly enhance blood perfusion recovery by promoting neovascularization in HLI mice. We revealed that salidroside promoted skeletal muscle cell migration and paracrine function through inhibiting the transcriptional level of prolyl-hydroxylase domain 3 (PHD3) without affecting PHD1 and PHD2. Paracrine signals from salidroside-treated skeletal muscle cells enhanced endothelial and smooth muscle cells migration, while inhibition of FGF2/FGF2R and PDGF-BB/PDGFR-beta pathways abolished this effect, as well as neovascularization in HLI mice. Furthermore, we elucidated that salidroside inhibition on PHD3 might occur through estrogen receptor alpha (ER alpha). Together, our findings highlights the potential application of salidroside as a novel pharmalogical inhibitor of ER alpha/PHD3 axis for therapeutic angiogenesis in HLI diseases.
C1 [Zhang, Jing; Kasim, Vivi; Xie, Yu-Dan; Huang, Can; Sisjayawan, Julita; Ariyanti, Agnes Dwi; Yan, Xue-Song; Wu, Xiao-Yan; Liu, Cai-Ping; Yang, Li; Wu, Shou-Rong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.
   [Yang, Li; Wu, Shou-Rong] Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing 400044, Peoples R China.
   [Miyagishi, Makoto] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Mol Composite Med Res Grp, Tsukuba, Ibaraki 3058566, Japan.
C3 Chongqing University; Chongqing University; National Institute of
   Advanced Industrial Science & Technology (AIST)
RP Kasim, V; Wu, SR (corresponding author), Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Wu, SR (corresponding author), Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing 400044, Peoples R China.
EM vivikasim@cqu.edu.cn; shourongwu@cqu.edu.cn
RI ; Kasim, Vivi/AID-0964-2022; Miyagishi, Makoto/L-8174-2016
OI Kasim, Vivi/0000-0001-9182-8230; Miyagishi, Makoto/0000-0001-7654-3616
FU National Natural Science Foundation of China [81372202, 31301119];
   Natural Science Foundation of Chongqing [cstc2014jcyjA10058];
   Specialized Research Fund for the Doctoral Program of Higher Education
   of China [20130191120035]; Fundamental Research Funds for the Central
   Universities [106112016CDJZR235516]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81372202, 31301119), the Natural Science Foundation
   of Chongqing (cstc2014jcyjA10058), the Specialized Research Fund for the
   Doctoral Program of Higher Education of China (No. 20130191120035) and
   the Fundamental Research Funds for the Central Universities
   (106112016CDJZR235516).
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NR 61
TC 40
Z9 48
U1 1
U2 23
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 7
PY 2017
VL 7
AR 43935
DI 10.1038/srep43935
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EN3ND
UT WOS:000395914300001
PM 28266625
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, YM
   Wang, XY
   Zhou, XR
   Zhang, C
   Liu, KJ
   Zhang, FY
   Xiang, B
AF Sun, Yue-Mei
   Wang, Xin-Yue
   Zhou, Xin-Ru
   Zhang, Chong
   Liu, Ke-Jian
   Zhang, Fu-Yin
   Xiang, Bin
TI Salidroside Ameliorates Radiation Damage by Reducing Mitochondrial
   Oxidative Stress in the Submandibular Gland
SO ANTIOXIDANTS
LA English
DT Article
DE radiation damage; submandibular gland; oxidative stress; salidroside;
   mitochondrion
ID IRRADIATION; RAT; INJURY; AMIFOSTINE; MECHANISM; GROWTH; ENZYME; HEAD;
   NECK; ROS
AB Radiotherapy for patients with head and neck cancer inevitably causes radiation damage to salivary glands (SGs). Overproduction of reactive oxygen species (ROS) leads to mitochondrial damage and is critical in the pathophysiology of SG radiation damage. However, mitochondrial-targeted treatment is unavailable. Herein, both in vitro and in vivo models of radiation-damaged rat submandibular glands (SMGs) were used to investigate the potential role of salidroside in protecting irradiated SGs. Cell morphology was observed with an inverted phase-contrast microscope. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), mitochondrial ROS, mitochondrial membrane potential (MMP), and ATP were measured using relevant kits. The mitochondrial ultrastructure was observed under transmission electron microscopy. Cell apoptosis was determined by Western blot and TUNEL assays. Saliva was measured from Wharton's duct. We found that salidroside protected SMG cells and tissues against radiation and improved the secretion function. Moreover, salidroside enhanced the antioxidant defense by decreasing MDA, increasing SOD, CAT, and GSH, and scavenging mitochondrial ROS. Furthermore, salidroside rescued the mitochondrial ultrastructure, preserved MMP and ATP, suppressed cytosolic cytochrome c and cleaved caspase 3 expression, and inhibited cell apoptosis. Together, these findings first identify salidroside as a mitochondrial-targeted antioxidant for preventing SG radiation damage.
C1 [Sun, Yue-Mei; Wang, Xin-Yue; Zhou, Xin-Ru; Zhang, Chong; Xiang, Bin] Dalian Med Univ, Hosp 2, Lab Oral & Maxillofacial Dis, Dalian 116023, Peoples R China.
   [Liu, Ke-Jian] SUNY Stony Brook, Stony Brook Canc Ctr, Renaissance Sch Med, Stony Brook, NY 11794 USA.
   [Zhang, Fu-Yin] Dalian Med Univ, Dept Oral Surg, Hosp 2, Dalian 116023, Peoples R China.
C3 Dalian Medical University; State University of New York (SUNY) System;
   Stony Brook University; Stony Brook University Hospital; Dalian Medical
   University
RP Xiang, B (corresponding author), Dalian Med Univ, Hosp 2, Lab Oral & Maxillofacial Dis, Dalian 116023, Peoples R China.; Zhang, FY (corresponding author), Dalian Med Univ, Dept Oral Surg, Hosp 2, Dalian 116023, Peoples R China.
EM ymsun163@163.com; xywang@dmu.edu.cn; zhouxr0210@163.com;
   rush914@163.com; kliu@salud.unm.edu; zhangfuyin@msn.com;
   xiangbin72@163.com
RI Zhou, xinru/KOC-7452-2024
OI Wang, Xinyue/0000-0003-3884-3348; Xiang, Bin/0000-0002-7623-6023
FU National Natural Science Foundation of China [81771091, 82103780]
FX This research was funded by grants from the National Natural Science
   Foundation of China (grant numbers: 81771091 and 82103780).
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NR 50
TC 9
Z9 15
U1 0
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1414
DI 10.3390/antiox11071414
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3J1KE
UT WOS:000833160900001
PM 35883904
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, PY
   Ji, JQ
   Zhang, Z
   Liu, X
   Pan, X
   Niu, CJ
   Wan, J
   Wen, CF
   Wang, RL
   Zheng, SY
   Liu, S
   Hou, HH
   Lu, J
AF Zhou, Pengyu
   Ji, Jianqiang
   Zhang, Zhong
   Liu, Xiu
   Pan, Xuan
   Niu, Chuanjie
   Wan, Jun
   Wen, Chaofan
   Wang, Ruiling
   Zheng, Shaoyi
   Liu, Shuai
   Hou, Honghao
   Lu, Jun
TI Salidroside-loaded metal-organic frameworks hydrogel to improve cardiac
   allograft function
SO JOURNAL OF HEART AND LUNG TRANSPLANTATION
LA English
DT Article
DE Metal-organic frameworks; Salidroside; Hydrogel; Ischemia/reperfusion
   injury; Heart transplantation
ID PRIMARY GRAFT DYSFUNCTION; HEART; TRANSPLANTATION; APOPTOSIS; PLASMA;
   INJURY
AB BACKGROUND: Ischemia-reperfusion injury (IRI) is a leading cause of primary graft dysfunction in heart transplantation. Metal-organic frameworks (MOFs) are widely applied as drug delivery carriers. Salidroside has been recognized for its potent anti-oxidative and anti-inflammatory effects. In this study, we developed the hydrogel incorporating salidroside-loaded MOF nanoparticles (Hydrogel/ MOFSP) and applied it to the surface of post-transplant donor hearts to alleviate myocardial IRI. METHODS: Hydrogel/MOFSP was synthesized to facilitate sustained and cardiac-targeted drug release for salidroside. We evaluated MOFSP nanoparticles or salidroside's anti-oxidative and anti-inflammatory properties in vitro. Furthermore, donor hearts were heterotopically transplanted after 3hour cold storage with PBS (vehicle group), or salidroside or Hydrogel/MOFSP applied to the surface of donor hearts immediately after in vivo reperfusion. We investigated the cardiac function and the levels of oxidative stress, inflammation, and apoptosis of donor hearts after 6-hour heart transplantation and the mechanism of the cardioprotective effect of Hydrogel/MOFSP. RESULTS: MOFSP nanoparticles or salidroside displayed anti-oxidative and anti-inflammatory properties in vitro, whereas applying Hydrogel/MOFSP rather than only salidroside to the surface of post-transplant grafts could improve cardiac function. Significantly reduced levels of myocardial oxidative stress, inflammation, and apoptosis were observed in the Hydrogel/MOFSP group. Hydrogel/ MOFSP mitigated myocardial IRI for post-transplant grafts through the downregulation of P38/mi-togen-activated protein kinase (MAPK) signaling pathway. CONCLUSIONS: Applying novel Hydrogel/MOFSP to the surface of post-transplant donor hearts improved graft function and alleviated myocardial IRI in heart transplantation. The cardioprotective effects of Hydrogel/ MOFSP were achieved through the downregulation of the P38/MAPK signaling pathway. J Heart Lung Transplant 2025;44:1621-1634 (c) 2025 International Society for Heart and Lung Transplantation. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Zhou, Pengyu; Ji, Jianqiang; Zhang, Zhong; Liu, Xiu; Pan, Xuan; Niu, Chuanjie; Wan, Jun; Wang, Ruiling; Zheng, Shaoyi; Lu, Jun] Southern Med Univ, Nanfang Hosp, Dept Cardiovasc Surg, 838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
   [Wen, Chaofan] Southern Med Univ, Sch Clin Med 1, Guangzhou, Guangdong, Peoples R China.
   [Liu, Shuai] Southern Med Univ, Affiliated Hosp 5, Guangzhou, Guangdong, Peoples R China.
   [Hou, Honghao] Southern Med Univ, Sch Basic Med Sci, Dept Anat, Guangdong Prov Key Lab Construct & Detect Tissue E, Guangzhou, Guangdong, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China; Southern Medical University
   - China
RP Lu, J (corresponding author), Southern Med Univ, Nanfang Hosp, Dept Cardiovasc Surg, 838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.; Liu, S (corresponding author), Southern Med Univ, Affiliated Hosp 5, Guangzhou, Guangdong, Peoples R China.; Hou, HH (corresponding author), Southern Med Univ, Sch Basic Med Sci, Dept Anat, Guangdong Prov Key Lab Construct & Detect Tissue E, Guangzhou, Guangdong, Peoples R China.
EM Lius0813@hotmail.com; hhou2019@smu.edu.cn; lujunwwwww@163.com
RI Hou, Honghao/HKN-1747-2023; liu, xiu/AAI-5445-2020
OI Hou, Honghao/0000-0002-7133-9760; zhang, zhong/0000-0002-5969-767X
FU National Natural Science Foundation of China [82170274, 82470418,
   82270410, 82200447, 82470476, 32371410, 52003113]; National Key R&D
   Program of China [2023YFC2412800]; Guangdong Basic and Applied Basic
   Research Foundation [2024A1515013074, 2022A1515011747, 2023A1515110517,
   2024A1515011430]; Medical Scientific Research Foundation of Guangdong
   Province, China [A2022547, A2023106]; Outstanding Youth Development
   Scheme of Nanfang Hospital of Southern Medical University [2023J004];
   President Foundation of Nanfang Hospital, Southern Medical University
   [2022A015]
FX The authors have no conflicts of interest to disclose. This research was
   supported by grants from the National Natural Science Foundation of
   China (82170274, 82470418, 82270410, 82200447, 82470476, 32371410, and
   52003113), National Key R&D Program of China (2023YFC2412800), Guangdong
   Basic and Applied Basic Research Foundation (2024A1515013074,
   2022A1515011747, 2023A1515110517, and 2024A1515011430), Medical
   Scientific Research Foundation of Guangdong Province, China (A2022547
   and A2023106), Outstanding Youth Development Scheme of Nanfang Hospital
   of Southern Medical University (2023J004), and the President Foundation
   of Nanfang Hospital, Southern Medical University (2022A015).
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NR 48
TC 2
Z9 2
U1 10
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1053-2498
EI 1557-3117
J9 J HEART LUNG TRANSPL
JI J. Heart Lung Transplant.
PD OCT
PY 2025
VL 44
IS 10
DI 10.1016/j.healun.2025.05.015
EA SEP 2025
PG 14
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery;
   Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery;
   Transplantation
GA 8AW7J
UT WOS:001584292200015
PM 40456428
DA 2026-05-27
ER

PT J
AU El-Kott, AF
   ElBealy, ER
   Alshehri, AS
   El-Kenawy, AE
   Khalifa, HS
   AlRamlawy, AM
AF El-Kott, Attalla F.
   ElBealy, Eman R.
   Alshehri, Ali S.
   El-Kenawy, Ayman E.
   Khalifa, Heba S.
   AlRamlawy, Amira M.
TI Salidroside induces cell apoptosis and inhibits the invasiveness of HT29
   colorectal cells by regulating protein kinase R, NF-κB and STAT3
SO CANCER BIOMARKERS
LA English
DT Article
DE Salidroside; colorectal; HT29; protein kinase R; STAT3; eIF-2 alpha;
   NF-kappa B
ID PROGNOSTIC-SIGNIFICANCE; COLON-CANCER; PKR; ACTIVATION; PROLIFERATION;
   INFLAMMATION; EXPRESSION; SURVIVAL; LEUKEMIA; IMPACT
AB BACKGROUND: Protein kinase R (PKR) can suppress various types of solid tumors by inducing cellular oxidative stress and apoptosis. Likewise, Slaidorside, a plant flavonoid, was shown to have anti-tumorigenesis in many solid tumors.
   OBJECTIVE: This study evaluated anti-tumorigenesis of Salidroside in HT29 colorectal cancer and investigated if the underlying mechanism involves activation of PKR.
   METHODS: Control or PKR deficient cells were cultured in DMEM media treated with 100 mu M Salidroside and cell survival, apoptosis, and other biochemical-related markers were evaluated.
   RESULTS: Salidroside significantly reduced cell survival and proliferation and increased the release of lactate dehydrogenase (LDH) and levels of single-stranded DNA (ssDNA). It also increased the protein levels of caspases 3 and 8. Concomitantly, Salidroside increased the protein level and activity of PKR and increased the expression of its downstream targets, p-eIE2 alpha (Ser(51)), p53 MAPK, and p53. On the contrary, it inhibited the nuclear activation of STAT-3 and NF-kappa B p65. In PKR deficient cells, the partial effects of Salidroside on cell survival, proliferation, and apoptotic markers were observed coincided with no effects on the expression of eIE-2 alpha, and JNK, p53, p38 MAPK, and caspase 8 but with a significant decrease in the nuclear activities of STAT3 and NF-kappa B.
   CONCLUSION: Salidroside suppresses the tumorigenesis of HT29 CRC by increasing activation of eIF-2 alpha and JNK and upregulation of p53, p38 MAPK, and caspase-8 through upregulating and activation of PKR. However, the tumor suppressor effect of Salidroside requires also inhibition of STAT3 and NF-kappa B in a PKR-independent mechanism.
C1 [El-Kott, Attalla F.; Alshehri, Ali S.] King Khalid Univ, Coll Sci, Biol Dept, Abha, Saudi Arabia.
   [El-Kott, Attalla F.; Khalifa, Heba S.] Damanhour Univ, Coll Sci, Zool Dept, Damanhour, Egypt.
   [ElBealy, Eman R.] King Khalid Univ, Coll Sci Girls, Biol Dept, Abha, Saudi Arabia.
   [El-Kenawy, Ayman E.] Taif Univ, Coll Med, Pathol Dept, At Taif, Saudi Arabia.
   [AlRamlawy, Amira M.] Mansoura Univ, Childrens Hosp, Mansoura Res Ctr Cord Stem Cell MARC CSC, Stem Cells Bank, Mansoura, Egypt.
C3 King Khalid University; Egyptian Knowledge Bank (EKB); Damanhour
   University; King Khalid University; Imam Abdulrahman Bin Faisal
   University; Taif University; Egyptian Knowledge Bank (EKB); Mansoura
   University
RP El-Kott, AF (corresponding author), King Khalid Univ, Coll Sci, Biol Dept, Abha, Saudi Arabia.
EM elkottaf@kku.edu.sa
RI El-kott, Attalla/D-1971-2017; Elbealy, Eman/HGA-3375-2022
OI El-kott, Attalla/0000-0001-5060-0790; Elbealy, Eman/0000-0001-6196-5840;
   Khalifa, Heba/0000-0003-4351-336X
FU deanship of Scientific Research at King Khalid University, Abha, KSA
   [R.G.P.2/80/41]; Taif University, Taif, Saudi Arabia [TURSP-2020/99]
FX The authors extend their appreciation to the deanship of Scientific
   Research at King Khalid University, Abha, KSA for supporting this work
   under grant number (R.G.P.2/80/41). Also, this work was supported by the
   Taif University Researchers Supporting Project Number (TURSP-2020/99),
   Taif University, Taif, Saudi Arabia.
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NR 50
TC 15
Z9 20
U1 0
U2 8
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1574-0153
EI 1875-8592
J9 CANCER BIOMARK
JI Cancer Biomark.
PY 2021
VL 31
IS 1
BP 13
EP 25
DI 10.3233/CBM-203257
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SK6EQ
UT WOS:000656307500002
PM 33749640
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zhang, R
   Li, N
   Fan, YF
   Qing, D
   Zhao, SJ
   Ren, XH
   Wang, AQ
   Gao, ZQ
   Fan, YC
AF Zhang, Rong
   Li, Ning
   Fan, Yuanfu
   Qing, Dai
   Zhao, Sijie
   Ren, Xiaohui
   Wang, Aiqin
   Gao, Ziqing
   Fan, Yuchen
TI A multi-omics study reveals molecular characteristics and therapeutic
   targets of salidroside in reducing TGF-(32-induced ECM expression
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE Primary open-angle glaucoma; TGF-(32; Salidroside; Trabecular meshwork;
   Multi-omics analysis
ID HUMAN TRABECULAR MESHWORK; RHODIOLA-ROSEA L.; AQUEOUS-HUMOR;
   INTRAOCULAR-PRESSURE; EXTRACELLULAR-MATRIX; OCULAR HYPERTENSION; ACID;
   PATHWAYS; GLAUCOMA
AB Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide, driven by elevated intraocular pressure (IOP) due to trabecular meshwork (TM) fibrosis, extracellular matrix (ECM) accumulation, and increased aqueous humor outflow resistance. Transforming growth factor-beta 2 (TGF-(32) promotes the expression of fibrosis-related genes, exacerbating these effects. Salidroside, a bioactive compound, has been shown to inhibit TGF-(32-induced ECM expression and alleviate ocular hypertension. However, its underlying molecular mechanisms remain unclear. This study explores the transcriptional, proteomic, and metabolic changes in human TM cells treated with TGF-(32 and salidroside. Human TM cells were treated with TGF-(32 (5 ng/mL) for 48 h, followed by salidroside (30 mu M) for 24 h. Multi-omics analyses, including transcriptomics, label-free proteomics, and non-targeted metabolomics, were performed to identify differentially expressed genes (DEGs), proteins (DEPs), and metabolites. The results revealed that TGF-(32 inhibited HTM cell metabolism, affecting pathways like the TCA cycle. Salidroside restores balance by regulating 15 key biomolecules, including MELTF and SLC25A10, through dual-level and post-translation mechanisms. ROC and docking analyses highlight salidroside's role in enhancing metabolic transport and energy activity, with SLC25A10 also linked to RNA processing, showcasing its therapeutic potential. These findings provide valuable insights into POAG pathogenesis and the therapeutic potential of salidroside, offering a foundation for the future development of novel treatment strategies targeting transcriptional, translational, and metabolic dysregulation in POAG.
C1 [Zhang, Rong; Li, Ning; Qing, Dai; Zhao, Sijie; Ren, Xiaohui; Wang, Aiqin; Gao, Ziqing; Fan, Yuchen] Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China.
   [Li, Ning; Qing, Dai; Zhao, Sijie; Ren, Xiaohui; Wang, Aiqin; Gao, Ziqing; Fan, Yuchen] Bengbu Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Bengbu, Anhui, Peoples R China.
   [Fan, Yuanfu] Huaiyuan Hosp Tradit Chinese Med, Dept Ophthalmol, Huaiyuan, Anhui, Peoples R China.
   [Fan, Yuchen] Bengbu Med Univ, Anhui Engn Technol Res Ctr Biochem Pharmaceut, Bengbu, Anhui, Peoples R China.
C3 Bengbu Medical University; Bengbu Medical University; Bengbu Medical
   University
RP Gao, ZQ; Fan, YC (corresponding author), Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China.
EM gaozq70@163.com; fanyuchendoctor@163.com
RI Qing, Dai/A-1751-2013
FU Anhui Engineering Technology Research Center of Biochemical
   Pharmaceutical (Bengbu Medical University) [22SYKFD01]; Foundation of
   Educational Department in Anhui province [KJ2021A0766, 2022AH051433];
   Foundation of Bengbu Medical University [2021byzd051, 2022byzd062];
   Natural Incubation Youth Project of Bengbu Medical University
   [2022byfy005]; Foundation of graduate research and innovation of Bengbu
   Medical College [Byycx23118]
FX This study was supported by the Anhui Engineering Technology Research
   Center of Biochemical Pharmaceutical (Bengbu Medical University) (NO:
   22SYKFD01) , Foundation of Educational Department in Anhui province (NO:
   KJ2021A0766 and 2022AH051433) , Foundation of Bengbu Medical University
   (NO: 2021byzd051, 2022byzd062) , The Natural Incubation Youth Project of
   Bengbu Medical University (2022byfy005) , and Foundation of graduate
   research and innovation of Bengbu Medical College (No. Byycx23118) .
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   Zhao P, 2018, MOL MED REP, V17, P5247, DOI 10.3892/mmr.2018.8480
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   Zhu HK, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11152004
NR 68
TC 0
Z9 0
U1 2
U2 3
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0014-4835
EI 1096-0007
J9 EXP EYE RES
JI Exp. Eye Res.
PD JUL
PY 2025
VL 256
AR 110386
DI 10.1016/j.exer.2025.110386
EA JUL 2025
PG 11
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA 2HC3J
UT WOS:001482506800001
PM 40216062
DA 2026-05-27
ER

PT J
AU Peng, LH
   Liu, S
   Xu, SY
   Chen, L
   Shan, YH
   Wei, W
   Liang, WQ
   Gao, JQ
AF Peng, Li-Hua
   Liu, Shuai
   Xu, Shen-Yao
   Chen, Lei
   Shan, Ying-Hui
   Wei, Wei
   Liang, Wen-Quan
   Gao, Jian-Qing
TI Inhibitory effects of salidroside and paeonol on tyrosinase activity and
   melanin synthesis in mouse B16F10 melanoma cells and ultraviolet
   B-induced pigmentation in guinea pig skin
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; Paeonol; Melanocytes; Tyrosinase; Melanin synthesis
ID IN-VITRO; MECHANISM; INCREASES; RESPONSES; EXTRACT; GROWTH; ACID; VIVO
AB Salidroside, the major active component of Rhodiola rosea, a herb with antioxidant, free radical scavenging and tyrosinase inhibitory effects, has been recently reported in protecting the kerationcytes from the UV radiation, suggesting the potential of this component in depigmentation. Paeonol is isolated from Moutan Cortex Radicis with anti-inflammation/microbial activities, was reported to induce the down-regulation of microphthalmia-associated transcription factor and subsequently tyrosinase. To testify the potential of these compounds as melanin formation inhibitors for hyperpigmentation therapy, the influence of salidroside and paeonol on pigmentation was investigated. With arbutin as a positive control, salidroside and paeonol were evaluated for their inhibitory effect on the cell viability, tyrosinase activity and melanin synthesis in B16F10 melanoma cells, as well as their effects in UVB-induced hyperpigmentation in brown guinea pig skins. It was demonstrated that the significant inhibition of salidroside (33.0%) and paeonol (22.2-30.9%) on the tyrosinase activity is slightly lower than that of arbutin (18.4-44.7%). However, salidroside exhibited the dose-dependent inhibition (30.6-42.0%) in melanin synthesis at a low concentration of 100 mu M, paeonol and arbutin expressed inhibition rates of 27.4-37.2% and 25.8-45.6% within 500-1000 p,M. The in vivo topical application of these compounds was demonstrated to obviously decrease the hyperpigmentation on UVB stimulated guinea pig skin. This study provided the original evidence for the salidroside and paeonol as therapeutic agents for pigmentation disorder and skin lightening, with further clinical investigation of these compounds in the field of depigmentation was suggested. (C) 2013 Elsevier GmbH. All rights reserved.
C1 [Peng, Li-Hua; Xu, Shen-Yao; Chen, Lei; Shan, Ying-Hui; Wei, Wei; Liang, Wen-Quan; Gao, Jian-Qing] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China.
   [Liu, Shuai] Shanghai Inst Pharmaceut Ind, Coll Pharmaceut Sci, Dept Pharmaceut, Shanghai, Peoples R China.
   [Gao, Jian-Qing] Novel Transdermal Preparat Res Ctr Jiangshu Prov, Nanjing, Peoples R China.
C3 Zhejiang University
RP Gao, JQ (corresponding author), Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM gaojianqing@zju.edu.cn
RI ; Gao, Jianqing/OUJ-2930-2025; wei, wei/IQW-1347-2023
OI Peng, Li-Hua/0000-0001-9763-383X; 
FU National Natural Science Foundation of China [81102393]; 48th China
   Postdoctoral Science Foundation [420000-X91004]; Foundation of
   Administration of Science & Technology of Wujin District, ChangZhou,
   China [WG2011025]; Zhejiang Provincial Program for the Cultivation of
   High-Level Innovative Health Talents; Fundamental Research Funds for the
   Central Universities, China
FX This research was supported by the National Natural Science Foundation
   of China (Grants No: 81102393), the 48th China Postdoctoral Science
   Foundation (Grant No: 420000-X91004), the Foundation of Administration
   of Science & Technology of Wujin District, ChangZhou, China (Grant No:
   WG2011025), the Zhejiang Provincial Program for the Cultivation of
   High-Level Innovative Health Talents, and the Fundamental Research Funds
   for the Central Universities, China.
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NR 45
TC 75
Z9 88
U1 1
U2 139
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD SEP 15
PY 2013
VL 20
IS 12
BP 1082
EP 1087
DI 10.1016/j.phymed.2013.04.015
PG 6
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 218SV
UT WOS:000324453700007
PM 23746955
DA 2026-05-27
ER

PT J
AU Cai, LL
   Li, YH
   Zhang, QQ
   Sun, HJ
   Yan, XD
   Hua, T
   Zhu, QF
   Xu, HT
   Fu, HL
AF Cai, Linlin
   Li, Yonghua
   Zhang, Qingqing
   Sun, Haijing
   Yan, Xiaodi
   Hua, Tong
   Zhu, Qiufeng
   Xu, Haitao
   Fu, Hailong
TI Salidroside protects rat liver against ischemia/reperfusion injury by
   regulating the GSK-3β/Nrf2-dependent antioxidant response and
   mitochondrial permeability transition
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Liver; Ischemia/reperfusion; Mitochondria; Glycogen
   synthase kinase-3 beta; NF-E2-related factor
ID ISCHEMIA-REPERFUSION; OXIDATIVE STRESS; HEME OXYGENASE-1; PATHWAY;
   ACTIVATION; MECHANISM; MEMBRANE; TYROSOL; CELLS; PORE
AB Salidroside (Sal) is a natural antioxidant that elicits cardioprotective and neuroprotective effects in vivo and in vitro; however, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. The purpose of this study was to investigate the hepatoprotective effects of salidroside against segmental (70%) warm hepatic I/R injury in rats. Animals were randomized into Sham, Sham+salidroside pretreatment (Sal), Sham+Sal +carboxyatractyloside (CATR), Sham+CATR, I/R, I/R+Sal, I/R+Sal+CATR and I/R+CATR groups. The hepatic artery, left portal vein and median liver lobes were occluded for 60 min and then undamped to allow reperfusion. Pretreatment with salidroside (20 mg/kg/day for 7 days, intraperitoneally) significantly decreased serum alanine aminotransferase (sALT) and serum aspartate aminotransferase (sAST) levels after 6 h and 24 h of reperfusion and protected the liver against I/R-induced injury. However, this protective effect could be reversed by CATR, a mitochondrial permeability transition pore (MPTP) opener (5 mg/kg 30 min before I/R insult, intraperitoneally). Mechanistic studies have revealed that salidroside inhibits glycogen synthase kinase-3 beta (GSK-3 beta) activity and enhances the NF-E2-related factor (Nrf2)-dependent antioxidant response by activating the Akt signaling pathway, thereby reducing mitochondrial reactive oxygen species generation, increasing MPTP resistance and preventing apoptosis by suppressing cytochrome c release and caspase activation during reperfusion. Therefore, salidroside ameliorates hepatocyte death and apoptosis through activation of the GSK-3 beta/Nrf2-dependent antioxidant response and subsequent MPTP inhibition. These results provide experimental evidence supporting the clinical use of salidroside for hepatoprotection in surgical settings.
C1 [Cai, Linlin; Li, Yonghua; Zhang, Qingqing; Sun, Haijing; Yan, Xiaodi; Hua, Tong; Zhu, Qiufeng; Xu, Haitao; Fu, Hailong] Second Mil Med Univ, Changzheng Hosp, Dept Anesthesiol, Shanghai, Peoples R China.
   [Cai, Linlin] Qingdao Univ, Yantai Yuhuangding Hosp, Dept Anesthesiol, Yantai, Peoples R China.
C3 Naval Medical University; Qingdao University
RP Xu, HT; Fu, HL (corresponding author), Second Mil Med Univ, Changzheng Hosp, Dept Anesthesiol, Shanghai, Peoples R China.
EM xuht1968@sohu.com; fuhailong1979@l63.com
RI yan, xiaodi/NRY-9204-2025
FU National Natural Scientific Foundation of China [81300344, 81670564];
   Medical Research Projects of the Science and Technology Commission of
   Shanghai Municipality (STCSM) [124119a3601]
FX This work was partially supported by grants from the National Natural
   Scientific Foundation of China (81300344 and 81670564 to H.L.F.) and
   Medical Research Projects of the Science and Technology Commission of
   Shanghai Municipality (STCSM) (124119a3601 to H.L.F.). The funders had
   no role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 54
TC 47
Z9 54
U1 0
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUL 5
PY 2017
VL 806
BP 32
EP 42
DI 10.1016/j.ejphar.2017.04.011
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EW0YI
UT WOS:000402216700005
PM 28411054
DA 2026-05-27
ER

PT J
AU Kang, DY
   Sp, N
   Kim, DH
   Joung, YH
   Lee, HG
   Park, YM
   Yang, YM
AF Kang, Dong Young
   Sp, Nipin
   Kim, Doh Hoon
   Joung, Youn Hee
   Lee, Hyo Gun
   Park, Young Min
   Yang, Young Mok
TI Salidroside inhibits migration, invasion and angiogenesis of MDA-MB 231
   TNBC cells by regulating EGFR/Jak2/STAT3 signaling via MMP2
SO INTERNATIONAL JOURNAL OF ONCOLOGY
LA English
DT Article
DE signal transducer and activator of transcription 3; matrix
   metalloproteinase 2; salidroside; breast cancer; angiogenesis
ID NEGATIVE BREAST-CANCER; JAK2/STAT3 PATHWAY; COLON-CANCER; GROWTH;
   EXPRESSION; APOPTOSIS; METASTASIS; PATTERNS; SUBTYPES; ARREST
AB The major hallmarks of tumor progression are angiogenesis, migration and metastasis. Among the components of Rhodiola rosea, salidroside (p-hydroxyphenethyl--d-glucoside) is one of the most potent, and is present in all Rhodiola species. Recent data have revealed the anticancer effects of salidroside; however, the mechanism underlying its ability to inhibit tumor angiogenesis remains unknown. The present study aimed to analyze how salidroside affects major factors involved in breast cancer, and to elucidate its ability to inhibit angiogenesis and invasion. Signal transducer and activator of transcription 3 (STAT3) is a marker for tumor angiogenesis and migration, which interacts with matrix metalloproteinases (MMPs). Specifically, MMPs act as a downstream target for STAT3. Using western blotting and reverse transcription-quantitative polymerase chain reaction analysis, the present study demonstrated that treatment of MDA-MB 231 triple-negative breast cancer (TNBC) cells with salidroside led to inhibition of invasion and migration markers, and of STAT3 signaling. Furthermore, in vitro angiogenesis analyses in human umbilical vein endothelial cells confirmed the anti-angiogenic activity of salidroside. An electrophoretic mobility shift assay also demonstrated that salidroside may inhibit the DNA-binding activity of STAT3, preventing STAT3 from binding to a novel binding site of the MMP2 gene promoter. In conclusion, the present results demonstrated that salidroside may downregulate the STAT3 signaling pathway, and inhibit cell viability, migration and invasion through MMPs in breast cancer cells.
C1 [Kang, Dong Young; Sp, Nipin; Kim, Doh Hoon; Joung, Youn Hee; Yang, Young Mok] Konkuk Univ, Inst Biomed Sci & Technol, Sch Med, Dept Pathol, 268 Chungwon Daero, Chungju 27478, Chungcheongbuk, South Korea.
   [Lee, Hyo Gun] Pusan Natl Univ, Coll Nat Resources & Life Sci, Dept Anim Sci, Miryang 50463, Gyeongsangnam, South Korea.
   [Park, Young Min] Konkuk Univ, Sch Med, Dept Immunol, Lab Dendrit Cell Differentiat & Regulat, Chungju 27478, Chungcheongbuk, South Korea.
C3 Konkuk University; Konkuk University Medical Center; Pusan National
   University; Konkuk University; Konkuk University Medical Center
RP Yang, YM (corresponding author), Konkuk Univ, Inst Biomed Sci & Technol, Sch Med, Dept Pathol, 268 Chungwon Daero, Chungju 27478, Chungcheongbuk, South Korea.
EM ymyang@kku.ac.kr
RI Sp, Nipin/HJP-1347-2023; , Nipin Sp/HJP-1347-2023
OI Lee, Hyo Gun/0000-0002-3286-7368; , Nipin Sp/0000-0003-1826-3135
FU Konkuk University
FX The present study received funding from Konkuk University in 2017.
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NR 35
TC 72
Z9 86
U1 0
U2 49
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1019-6439
EI 1791-2423
J9 INT J ONCOL
JI Int. J. Oncol.
PD AUG
PY 2018
VL 53
IS 2
BP 877
EP 885
DI 10.3892/ijo.2018.4430
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GP1MZ
UT WOS:000440581500037
PM 29901185
OA Bronze
DA 2026-05-27
ER

PT J
AU Li, CZ
   Deng, H
   Liu, ZY
   Lv, XQ
   Gao, WZ
   Gao, YC
   Gao, JH
   Hu, LF
AF Li, Cunzhi
   Deng, Hui
   Liu, Zhiyong
   Lv, Xiaoqiang
   Gao, Wenzhi
   Gao, Yongchao
   Gao, Junhong
   Hu, Lifang
TI Salidroside protect Chinese hamster V79 cells from genotoxicity and
   oxidative stress induced by CL-20
SO TOXICOLOGY RESEARCH
LA English
DT Article
DE hexanitrohexaazaisowurtzitane; genotoxicity; oxidative stress;
   salidroside; alkaline comet assay; mtDNA mutation
ID MITOCHONDRIAL-DNA MUTATIONS; DAMAGE; NEUROTOXICITY; TOXICITY; INJURY
AB Hexanitrohexaazaisowurtzitane (CL-20) is a high-energy elemental explosive widely used in chemical and military fields. CL-20 harms environmental fate, biosafety, and occupational health. However, there is little known about the genotoxicity of CL-20, in particular its molecular mechanisms. Therefore, this study was framed to investigate the genotoxic mechanisms of CL-20 in V79 cells and evaluate whether the genotoxicity could be diminished by pretreating the cells with salidroside. The results showed that CL-20-induced genotoxicity in V79 cells primarily through oxidative damage to DNA and mitochondrial DNA (mtDNA) mutation. Salidroside could significantly reduce the inhibitory effect of CL-20 on the growth of V79 cells and reduce the levels of reactive oxygen species (ROS), 8-hydroxy-2 deoxyguanosine (8-OHdG), and malondialdehyde (MDA). Salidroside also restored CL-20-induced superoxide dismutase (SOD) and glutathione (GSH) in V79 cells. As a result, salidroside attenuated the DNA damage and mutations induced by CL-20. In conclusion, oxidative stress may be involved in CL-20-induced genotoxicity in V79 cells. Salidroside could protect V79 cells from oxidative damage induced by CL-20, mechanism of which may be related to scavenging intracellular ROS and increasing the expression of proteins that can promote the activity of intracellular antioxidant enzymes. The present study for the mechanisms and protection of CL-20-mediated genotoxicity will help further to understand the toxic effects of CL-20 and provide information on the therapeutic effect of salidroside in CL-20-induced genotoxicity.
C1 [Li, Cunzhi; Hu, Lifang] Northwestern Polytech Univ, Sch Life Sci, Xian Key Lab Special Med & Hlth Engn, Key Lab Space Biosci & Biotechnol,Lab Bone Metab, 127 Youyi West Rd, Xian 710072, Shaanxi, Peoples R China.
   [Li, Cunzhi; Deng, Hui; Liu, Zhiyong; Lv, Xiaoqiang; Gao, Wenzhi; Gao, Yongchao; Gao, Junhong] Inst Hyg Ordnance Ind, Toxicol Res Ctr, 12 Zhangbadong Rd, Xian 710065, Shaanxi, Peoples R China.
   [Hu, Lifang] Northwestern Polytech Univ, 127 Youyi West Rd, Xian 710072, Shaanxi, Peoples R China.
   [Gao, Junhong] Inst Hyg Ordnance Ind, 12 Zhangba East Rd, Xian 710065, Shaanxi, Peoples R China.
C3 Northwestern Polytechnical University; Northwestern Polytechnical
   University
RP Hu, LF (corresponding author), Northwestern Polytech Univ, 127 Youyi West Rd, Xian 710072, Shaanxi, Peoples R China.; Gao, JH (corresponding author), Inst Hyg Ordnance Ind, 12 Zhangba East Rd, Xian 710065, Shaanxi, Peoples R China.
EM bqgywsyjs521@163.com; hulifang@nwpu.edu.cn
RI Hu, Lifang/W-8020-2019
FU Open Cooperation Innovation Fund Project of Xi'an Modern Chemistry
   Research Institute [SYJJ20210409]
FX This work was supported by the Open Cooperation Innovation Fund Project
   of Xi'an Modern Chemistry Research Institute (SYJJ20210409).
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NR 60
TC 4
Z9 6
U1 1
U2 23
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PD FEB 28
PY 2023
VL 12
IS 1
BP 133
EP 142
DI 10.1093/toxres/tfad004
EA FEB 2023
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 9H6IQ
UT WOS:000924028600001
PM 36866208
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Yu, XB
   Xu, BB
   Zhang, MD
   Yao, XL
   Xu, K
   Xie, XX
   Shen, X
   Gao, FY
AF Yu, Xiaobo
   Xu, Binbin
   Zhang, Mingdong
   Yao, Xuelian
   Xu, Kun
   Xie, Xiaoxiao
   Shen, Xiao
   Gao, Fengying
TI Salidroside Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting
   Ferroptosis Through the MAFK/lncRNA PTOV1-AS2/miR-525-5p/ACE2 Axis
SO FASEB JOURNAL
LA English
DT Article
DE ACE2; ferroptosis; lncRNA PTOV1-AS2; lung ischemia-reperfusion injury;
   MAFK; miR-525-5p; salidroside
ID ISCHEMIA/REPERFUSION INJURY; CELLS
AB This study aimed to explore the mechanism by which salidroside alleviates lung ischemia-reperfusion injury (LIRI) through the lncRNA PTOV1-AS2/miR-525-5p/ACE2 axis, with a specific focus on its role in regulating ferroptosis. In the murine model of LIRI, we administered salidroside either alone or in combination with adenoviral vectors for overexpression or knockdown of PTOV1-AS2 or ACE2. Subsequently, we examined lung histopathological changes, evaluated the severity of pulmonary edema, and assessed the levels of lung damage and inflammation. Additionally, an in vitro model was established using MLE12 cells induced by oxygen-glucose deprivation/reoxygenation (OGD/R), and relative cell viability and reactive oxygen species (ROS) levels were measured. The interactions between PTOV1-AS2 and miR-525-5p, as well as between miR-525-5p and ACE2, were predicted and confirmed through a series of assays. Moreover, the relationship between the transcription factor MAFK and lncRNA PTOV1-AS2 was investigated. The results revealed that salidroside upregulated ACE2 expression, thereby reducing lung injury, inflammation, and ferroptosis in both LIRI mice and OGD/R-induced MLE12 cells. Mechanistically, PTOV1-AS2 served as a competing endogenous RNA (ceRNA) to sponge miR-525-5p, thereby enhancing ACE2 expression, and this regulatory effect was further strengthened by salidroside treatment. Furthermore, it was found that MAFK directly bound to the promoter of PTOV1-AS2, promoting its transcription and subsequent expression. In conclusion, salidroside enhances resistance to ferroptosis and alleviates LIRI through the MAFK/PTOV1-AS2/miR-525-5p/ACE2 signaling axis, which provides new insights into the therapeutic potential of salidroside in LIRI.
C1 [Yu, Xiaobo] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Thorac Surg, Sch Med, Shanghai, Peoples R China.
   [Yu, Xiaobo; Xu, Binbin; Zhang, Mingdong; Yao, Xuelian; Xu, Kun; Xie, Xiaoxiao; Shen, Xiao] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Thorac Surg, Jiading Branch,Sch Med, Shanghai, Peoples R China.
   [Gao, Fengying] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Pulm Dis, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   University of Traditional Chinese Medicine
RP Gao, FY (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Pulm Dis, Shanghai, Peoples R China.
EM fengyinggao@outlook.com
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NR 50
TC 0
Z9 0
U1 3
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD DEC 2
PY 2025
VL 39
IS 23
AR e71291
DI 10.1096/fj.202502335R
PG 18
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA K7066
UT WOS:001628825700001
PM 41329068
DA 2026-05-27
ER

PT J
AU Ju, RJ
   Huang, RJ
   Zhou, J
   Li, RJ
   Zhou, P
   Zhang, ZH
   Xiang, FJ
   Xu, DJ
   Liu, WX
   Ma, XT
   Zhang, Q
   Lu, WL
AF Ju RuiJun
   Huang RenJie
   Zhou Jia
   Li RuoJing
   Zhou Peng
   Zhang ZaoHua
   Xiang FeiJun
   Xu DongJin
   Liu WeiXiang
   Ma XingTian
   Zhang Qiang
   Lu WanLiang
TI Separation of injectable salidroside by column chromatography of
   macroporous resins for treating myocardial ischemia
SO SCIENCE CHINA-CHEMISTRY
LA English
DT Article
DE large-scale separation; salidroside; marcroporous resin; rhodiola
   kirilowii; injectable ingredient; HPLC
ID RHODIOLA-SACHALINENSIS; PURIFICATION; ADSORPTION; INJURY; ROSEA
AB The objective of the present study is to develop a method for large-scale separating and purifying salidroside from rhodiola kirilowii roots and for preparing injectable medicinal ingredient. Crude extract of salidroside was prepared by water-ethanol system, and purified by column chromatography of macroporous resins. Static adsorption and desorption studies were performed on six kinds of macroporous resins, and SP825 resin was chosen, followed by optimizing process parameters. The optimum sample volume, feed concentration, ratio of diameter to height, and feeding flow rate were 1.5 bed volumes (BV), 15 mg/mL, 1:10 and 1 BV/h, respectively. Dynamic desorption was performed consecutively with 8 BV of distilled water, 3 BV of 5% ethanol and 8 BV of 10% ethanol at a flow rate of 2 BV/h. After three cycles in separating 3.5 tons of rhodiola kirilowii roots, salidroside purity was increased from 3.4% in the crude extract to 93.6% in purified salidroside product. This study provides a novel method to separate salidroside for injectable use.
C1 [Ju RuiJun; Zhou Jia; Li RuoJing; Zhou Peng; Zhang Qiang; Lu WanLiang] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
   [Huang RenJie] Fujian Hlth Coll, Dept Pharm, Fuzhou 350101, Peoples R China.
   [Zhang ZaoHua] China Acad Chinese Med Sci, Beijing 100700, Peoples R China.
   [Xiang FeiJun; Xu DongJin; Liu WeiXiang; Ma XingTian] Kangmei Pharmaceut Co Ltd, Puning 515300, Peoples R China.
C3 Peking University; China Academy of Chinese Medical Sciences
RP Lu, WL (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
EM luwl@bjmu.edu.cn
RI ; zhang, qiang/HZJ-9551-2023; Zhou, Peng/HZK-1567-2023
OI Zhou, Jia/0000-0001-7168-5690; Lu, Wan-Liang/0000-0002-5651-4890; 
FU Puning Kangmei Pharmaceutical Co., Ltd.; Comprehensive Center for Drug
   Discovery and Development of Peking University
FX This study was financially supported by Puning Kangmei Pharmaceutical
   Co., Ltd., and in part by Comprehensive Center for Drug Discovery and
   Development of Peking University.
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NR 28
TC 3
Z9 3
U1 0
U2 28
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1674-7291
EI 1869-1870
J9 SCI CHINA CHEM
JI Sci. China-Chem.
PD JUL
PY 2012
VL 55
IS 7
BP 1435
EP 1444
DI 10.1007/s11426-011-4471-z
PG 10
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 969QL
UT WOS:000306070500033
DA 2026-05-27
ER

PT J
AU Zhu, XZ
   Ren, T
   Xiong, QS
   Lin, ZF
   Lin, XX
   Lin, GY
AF Zhu, Xiaozhen
   Ren, Ting
   Xiong, Qiushuang
   Lin, Zhengfeng
   Lin, Xiaoxiao
   Lin, Guangyong
TI Salidroside alleviates diet-induced obesity and insulin resistance by
   activating Nrf2/ARE pathway and enhancing the thermogenesis of adipose
   tissues
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE insulin resistance; Nrf2; obesity; salidroside; thermogenesis
AB Recent reports suggest that salidroside protects cardiomyocytes from oxidative injury and stimulates glucose uptake by skeletal muscle cells. Despite these findings, the therapeutic potential of salidroside in the treatment of obesity and insulin resistance remains uncertain and requires further investigation. In the present study, the treatment effect of salidroside on the onset and development of the obese phenotype and insulin resistance as well as the underlying mechanisms was investigated using long-term high-fat diet-induced obese mice supplemented with salidroside. We used biochemical kits to determine serum biochemical parameters (including triacylglycerol, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting glucose, and insulin). The results show that salidroside-supplemented animals showed better glucose tolerance and insulin sensitivity, decreased blood lipids, and weight gain (p < .05). Protein expression of p-Nrf2 and Nrf2 was analyzed by western blotting, and the mRNA levels of thermogenic-related genes (Ucp1, Pgc1a, Prdm16, and Cidea) were detected by quantitative RT-PCR. The results show an improvement in lipid peroxidation and Nrf2/ARE signaling, as well as an increased expression of the Ucp1, Pgc1a, Prdm16, and Cidea (p < .05). Our evidence suggests that salidroside alleviates diet-induced obesity and insulin resistance potentially by activating Nrf2/ARE pathway and enhancing the thermogenesis of adipose tissues. This induction represents a potential technique for the management of comorbidities related to obesity and its prevention.
C1 [Zhu, Xiaozhen; Xiong, Qiushuang; Lin, Zhengfeng; Lin, Xiaoxiao; Lin, Guangyong] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou 325000, Zhejiang, Peoples R China.
   [Zhu, Xiaozhen; Xiong, Qiushuang; Lin, Zhengfeng; Lin, Xiaoxiao; Lin, Guangyong] Wenzhou Med Univ, Yuying Childrens Hosp, Dept Pharm, Wenzhou 325000, Zhejiang, Peoples R China.
   [Ren, Ting] Wenzhou Univ, Coll Life & Environm Sci, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou
   University
RP Lin, GY (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou 325000, Zhejiang, Peoples R China.; Lin, GY (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, Dept Pharm, Wenzhou 325000, Zhejiang, Peoples R China.
EM guang91_cn@126.com
RI zhu, xiaozhen/GRR-8495-2022
FU Study on the anti-ovarian cancer effect of Silibinin and the mechanism
   of sensitizing platinum chemotherapeutic drugs [2020KY647]
FX Study on the anti-ovarian cancer effect of Silibinin and the mechanism
   of sensitizing platinum chemotherapeutic drugs, Grant/Award Number:
   2020KY647
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NR 37
TC 6
Z9 8
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD AUG
PY 2023
VL 11
IS 8
BP 4735
EP 4744
DI 10.1002/fsn3.3450
EA JUN 2023
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA W7DX8
UT WOS:001001068800001
PM 37576042
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Liu, MW
   Su, MX
   Qin, LF
   Liu, X
   Tian, ML
   Zhang, W
   Wang, YH
AF Liu, Ming-Wei
   Su, Mei-Xian
   Qin, Lan-Fang
   Liu, Xu
   Tian, Mao-Li
   Zhang, Wei
   Wang, Yun-Hui
TI Effect of salidroside on lung injury by upregulating peroxisome
   proliferator-activated receptor γ expression in septic rats
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE sepsis; peroxisome proliferator-activated receptor gamma; salidroside;
   rat; cecal ligation and puncture; lung injury
ID KAPPA-B; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); NEUTROPHIL
   RECRUITMENT; VASCULAR LEAKAGE; ALPHA EXPRESSION; FLUID CLEARANCE;
   APOPTOSIS; MICE; INDUCTION; MECHANISM
AB Successful drug treatment for sepsis-related acute lung injury (ALI) remains a major clinical problem. Thus, the aim of the present study was to investigate the beneficial effects of salidroside on ameliorating cecal ligation and puncture (CLP)-induced lung inflammation. Rats underwent CLP surgery to induce ALI and 800 mg/kg salidroside (i.v.) was administered 24 h after the CLP challenge. Subsequently, biochemical changes in the blood and lung tissues, as well as morphological and histological alterations in the lungs, that were associated with inflammation and injury were analysed. CLP was shown to significantly increase the serum levels of plasma tumour necrosis factor-a and interleukin-6, -1 beta and-10. In addition, CLP increased pulmonary oedema, thickened the alveolar septa and caused inflammation in the lung cells. These changes were ameliorated by the administration of 800 mg/kg salidroside (i.v.) 24 h after the CLP challenge. This post-treatment drug administration also significantly attenuated the lipopolysaccharide-induced activation of nuclear factor-kappa beta and increased the release of peroxisome proliferator-activated receptor gamma in the lung tissue. Therefore, salidroside administered following the induction of ALT by CLP significantly prevented and reversed lung tissue injuries. The positive post-treatment effects of salidroside administration indicated that salidroside may be a potential candidate for the management of lung inflammation in CLP-induced endotoxemia and septic shock.
C1 [Liu, Ming-Wei; Qin, Lan-Fang; Zhang, Wei; Wang, Yun-Hui] Kunming Med Univ, Affiliated Hosp 1, Dept Emergency, Kunming 650032, Yunnan, Peoples R China.
   [Su, Mei-Xian] Kunming Med Univ, Affiliated Hosp 2, Surg Intens Care Unit, Kunming 650106, Yunnan, Peoples R China.
   [Liu, Xu; Tian, Mao-Li] Kunming Med Univ, Yanan Hosp, Dept Infect Dis, Kunming 650051, Yunnan, Peoples R China.
C3 Kunming Medical University; Kunming Medical University; Kunming Medical
   University
RP Wang, YH (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Dept Emergency, 295 Xichang Rd, Kunming 650051, Yunnan, Peoples R China.
EM wangyunhui62@foxmail.com
RI Liu, Ming-Wei/AFL-8981-2022
FU Yunnan Science and Technology Foundation of China [2010C093]
FX The authors thank Professor Mei-Xian Sun and Professor Lan-Fang Qin for
   their kind and excellent technical assistance. The study was supported
   by a grant from the Yunnan Science and Technology Foundation of China
   (no. 2010C093).
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NR 34
TC 13
Z9 14
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUN
PY 2014
VL 7
IS 6
BP 1446
EP 1456
DI 10.3892/etm.2014.1629
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AI0QX
UT WOS:000336555100002
PM 24926325
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Feng, Q
   Liu, C
   Gao, W
   Geng, XL
   Dai, N
AF Feng, Qi
   Liu, Chen
   Gao, Wei
   Geng, Xiao-ling
   Dai, Ning
TI Salidroside-Mitigated Inflammatory Injury of Hepatocytes with
   Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel
   Activation
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE non-alcoholic fatty liver disease; salidroside; TRPM2 ion channel;
   autophagy; cytokines
ID INSULIN-RESISTANCE; STEATOHEPATITIS; ACCUMULATION; EXPRESSION; ACID
AB Purpose: Oxidative stress plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). TRPM2 ion channel functions as a molecular sensor for oxidative stress. The aim of this study was to examine the protective effects of Salidroside, a powerful antioxidative plant, on TRPM2 in an established in vitro model of NAFLD.
   Methods: NAFLD model was established by palmitic acid (PA) in hepatic L02 cell lines and was added to the media at a final concentration of 400 mu M. Cells were used as normal group, PA group and PA receiving varied concentrations of Salidroside (75 mu g/mL, 150 mu g/ mL, 300 mu g/mL). After treating 24 hrs, MTT assay was used to detect cell viability, and ALT level was measured using an appropriate kit assay. Intracellular lipid accumulation was observed by Oil red O staining. Cytosolic Ca2+ concentrations were evaluated by flow cytometer with Fluo-3/AM. Quantitative RT-PCR was used to measure the mRNA expression of TRPM2, IL-1 beta and IL-6, and the protein expressions of TRPM2, p-CaMKII and autophagy (LC3B, p62) were determined using Western blot.
   Results: Treatment with Salidroside effectively restored liver injury and alleviated lipid droplet deposition in a dose-dependent manner, which was associated with inhibition of TRPM2/Ca2+/CaMKII pathway. Additionally, autophagic clearance was enhanced by intervention with Salidroside in a dose-dependent manner. Further investigation indicated that Salidroside down-regulated the mRNA expression of IL-1 beta and IL-6-pro-inflammatory cytokines.
   Conclusion: These results suggest that Salidroside could alleviate inflammatory injury and steatosis via autophagy activation mediated by downregulation of the TRPM2/Ca2+/CaMKII pathway. Targeting the TRPM2 ion channel is a novel treatment strategy for oxidative stress-induced liver in NAFLD.
C1 [Feng, Qi; Liu, Chen; Gao, Wei; Geng, Xiao-ling; Dai, Ning] Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Zhongshan Rd, Dalian 116011, Liaoning, Peoples R China.
C3 Dalian Medical University
RP Dai, N (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Zhongshan Rd, Dalian 116011, Liaoning, Peoples R China.
EM ning_dldn@outlook.com
FU Liaoning Nature Science Fund [20180550081]
FX This research was funded by Liaoning Nature Science Fund (20180550081),
   China.
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NR 44
TC 22
Z9 27
U1 0
U2 19
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 2755
EP 2763
DI 10.2147/DMSO.S210764
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JZ1XO
UT WOS:000504897700001
PM 31920355
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, YC
   Han, JX
   Luo, LL
   Kasim, V
   Wu, SR
AF Wang, Yicheng
   Han, Jingxuan
   Luo, Lailiu
   Kasim, Vivi
   Wu, Shourong
TI Salidroside facilitates therapeutic angiogenesis in diabetic hindlimb
   ischemia by inhibiting ferroptosis
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Diabetic HLI; Therapeutic angiogenesis; Salidroside; Skeletal muscle
   cells; Ferroptosis
ID PERIPHERAL ARTERIAL-DISEASE; CRITICAL LIMB ISCHEMIA; INTER-SOCIETY
   CONSENSUS; CELL-DEATH; MUSCLE; MECHANISMS; EXPRESSION; DYSFUNCTION;
   MANAGEMENT; MICE
AB Hindlimb ischemia (HLI), in which blood perfusion to the hindlimb is obstructed, is one of the major complications of diabetes. Skeletal muscle cells are crucial for revascularization as they can secrete various angiogenic factors; however, hyperglycemia impairs their viability and subsequently their angiogenic potential. Salidroside can promote skeletal muscle cell viability under hyperglycemia; however, the molecular mechanism is still poorly understood. Here we revealed that salidroside could suppress hyperglycemia-induced ferroptosis in skeletal muscle cells by promoting GPX4 expression, thereby restoring their viability and paracrine functions. These in turn promoted the proliferation and migration potentials of blood vessel-forming cells. Furthermore, we showed that salidroside/GPX4-mediated ferroptosis inhibition is crucial for promoting angiogenesis and blood perfusion recovery in diabetic HLI mice. Together, we reveal a novel molecular mechanism of salidroside in enhancing skeletal muscle cells-mediated revascularization and blood perfusion recovery in diabetic HLI mice, further highlighting it as a potential compound for treating diabetic HLI.
C1 [Wang, Yicheng; Han, Jingxuan; Luo, Lailiu; Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.
   [Wang, Yicheng; Han, Jingxuan; Luo, Lailiu; Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing 400044, Peoples R China.
   [Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, State & Local Joint Engn Lab Vasc Implants, Chongqing 400044, Peoples R China.
C3 Chongqing University; Chongqing University; Chongqing University
RP Kasim, V; Wu, SR (corresponding author), Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.
EM vivikasim@cqu.edu.cn; shourongwu@cqu.edu.cn
RI ; Kasim, Vivi/AID-0964-2022
OI Kasim, Vivi/0000-0001-9182-8230; Wu, Shourong/0000-0001-9650-5465; 
FU National Natural Science Foundation of China [31871367, 81872273];
   Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0611,
   CSTB2022NSCQ-MSX0612]
FX Funding This work is financially supported by the National Natural
   Science Foundation of China (31871367 and 81872273) , the Natural
   Science Foundation of Chongqing (CSTB2022NSCQ-MSX0611 and
   CSTB2022NSCQ-MSX0612) .
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NR 68
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U1 2
U2 27
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2023
VL 159
AR 114245
DI 10.1016/j.biopha.2023.114245
EA JAN 2023
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 8K4WC
UT WOS:000923103100001
PM 36638593
OA gold
DA 2026-05-27
ER

PT J
AU Tao, K
   Wang, B
   Feng, DY
   Zhang, W
   Lu, FF
   Lai, J
   Huang, L
   Nie, TJ
   Yang, Q
AF Tao, Kai
   Wang, Bao
   Feng, Dayun
   Zhang, Wei
   Lu, Fangfang
   Lai, Juan
   Huang, Lu
   Nie, Tiejian
   Yang, Qian
TI Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by
   Attenuating ER Stress
SO NEUROSCIENCE BULLETIN
LA English
DT Article
DE Parkinson's disease; ER stress; Salidroside; 6-OHDA; Neuroprotection
ID ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; PARKINSONS-DISEASE;
   MODULATION; APOPTOSIS; SURVIVAL; ENTRY
AB Parkinson's disease (PD) is a neurodegenerative disease characterized by a persistent decline of dopaminergic (DA) neurons in the substantia nigra pars compacta. Despite its frequency, effective therapeutic strategies that halt the neurodegenerative processes are lacking, reinforcing the need to better understand the molecular drivers of this disease. Importantly, increasing evidence suggests that the endoplasmic reticulum (ER) stress-induced unfolded protein response is likely involved in DA neuronal death. Salidroside, a major compound isolated from Rhodiola rosea L., possesses potent anti-oxidative stress properties and protects against DA neuronal death. However, the underlying mechanisms are not well understood. In the present study, we demonstrate that salidroside prevents 6-hydroxydopamine (6-OHDA)-induced cytotoxicity by attenuating ER stress. Furthermore, treatment of a DA neuronal cell line (SN4741) and primary cortical neurons with salidroside significantly reduced neurotoxin-induced increases in cytoplasmic reactive oxygen species and calcium, both of which cause ER stress, and cleaved caspase-12, which is responsible for ER stress-induced cell death. Together, these results suggest that salidroside protects SN4741 cells and primary cortical neurons from 6-OHDA-induced neurotoxicity by attenuating ER stress. This provides a rationale for the investigation of salidroside as a potential therapeutic agent in animal models of PD.
C1 [Tao, Kai; Wang, Bao; Feng, Dayun; Lu, Fangfang; Lai, Juan; Huang, Lu; Nie, Tiejian; Yang, Qian] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China.
   [Zhang, Wei] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710038, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Yang, Q (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China.
EM qianyang@fmmu.edu.cn
RI Yang, Qian/HTS-5357-2023
OI Yang, Qian/0000-0001-5986-2682
FU National Basic Research Development Program (973 Program) of China
   [2011CB510000]; National Natural Science Foundation of China [31371400]
FX We thank American Journal Experts for critical modification of this
   manuscript. This work was supported by the National Basic Research
   Development Program (973 Program) of China (2011CB510000) and the
   National Natural Science Foundation of China (31371400).
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NR 28
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Z9 43
U1 1
U2 30
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1673-7067
EI 1995-8218
J9 NEUROSCI BULL
JI Neurosci. Bull.
PD FEB
PY 2016
VL 32
IS 1
BP 61
EP 69
DI 10.1007/s12264-015-0001-x
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DC7WE
UT WOS:000369430500006
PM 26762342
OA Bronze
DA 2026-05-27
ER

PT J
AU Han, T
AF Han, Tian
TI Effects of salidroside pretreatment on expression of tumor necrosis
   factor-alpha and permeability of blood brain barrier in rat model of
   focal cerebralischemia-reperfusion injury
SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
LA English
DT Article
DE Salidroside; Cerebralischemia reperfusion; Blood brain barrier; Cytokine
ID ISCHEMIA
AB Objective: To observe changes in expression of tumor necrosis factor (TNF)-alpha and permeability of blood brain barrier after salidroside pretreatment in rats with injury induced by focal cerebralischemia-reperfusion. Methods: Forty-five male SD rats were randomly divided into three groups (n=15): control group, ischemia-reperfusion (IR) model group, and salidroside pretreatment group. Before the IR model establishment, the rats in the salidroside pretreatment group were intraperitoneally administered with salidroside at a dose of 24 mg/(kg.d) for 7 d. After 30 mm post the last administration, the IR model was induced by occlusion of middle cerebral artery with a filament. After 24 h post the operation, the water content and Evens blue content in the ischemia cerebral hemisphere were determined, and the level of TNF-alpha mRNA was detected by the semi quantitative RT-PCR. Results: Compared with the IR model group, the salidroside pretreatment group had significantly lower (P<0.05) water content and Evens blue content in the ischemia cerebral hemisphere and also had significantly lower (P<0.05) level of TNF-alpha in the ischemic cerebral cortex tissue. Conclusions: The salidroside pretreatment alleviated the focal cerebralischemia-reperfusion injury in the rat model, possibly by decreasing the permeability of blood brain barrier, attenuating brain edema and reducing TNF-alpha expression.
C1 Baoding Second Cent Hosp, Dept Anesthesiol, Baoding 072750, Peoples R China.
RP Han, T (corresponding author), Baoding Second Cent Hosp, Dept Anesthesiol, Baoding 072750, Peoples R China.
EM hantian2005@yahoo.cn
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NR 8
TC 28
Z9 38
U1 0
U2 20
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1995-7645
J9 ASIAN PAC J TROP MED
JI Asian Pac. J. Trop. Med.
PD FEB
PY 2013
VL 6
IS 2
BP 156
EP 158
DI 10.1016/S1995-7645(13)60014-0
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 083EZ
UT WOS:000314446800014
PM 23339921
OA gold
DA 2026-05-27
ER

PT J
AU Bai, XL
   Jia, X
   Lu, YJ
   Zhu, L
   Zhao, Y
   Cheng, WZ
   Shu, M
   Jin, S
AF Bai, Xiangli
   Jia, Xiong
   Lu, Yajing
   Zhu, Lin
   Zhao, Ying
   Cheng, Wenzhuo
   Shu, Meng
   Jin, Si
TI Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1
   Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LIPID RAFTS; IN-VIVO; ATHEROSCLEROSIS; PHOSPHORYLATION; MEMBRANE; AMPK;
   LDL
AB Subendothelial retention of apolipoprotein B100-containing lipoprotein, such as low-density lipoprotein (LDL), is the initial step of atherogenesis. Activation of autophagy exhibits beneficial effects for the treatment of atherosclerosis. In our previous study, we demonstrated that hyperglycemia suppressed autophagic degradation of caveolin-1, which in turn resulted in acceleration of caveolae-mediated LDL transcytosis across endothelial cells and lipid retention. Therefore, targeting the crossed pathway in autophagy activation and LDL transcytosis interruption may be a promising antiatherosclerotic strategy. In metabolic diseases, including atherosclerosis, salidroside, a phenylpropanoid glycoside compound (3,5-dimethoxyphenyl) methyl-beta-glucopyranoside), is the most important compound responsible for the therapeutic activities ofRhodiola. However, whether salidroside suppresses LDL transcytosis to alleviate atherosclerosis has not yet been elucidated. In the present study, we demonstrated that salidroside significantly decreased LDL transcytosis across endothelial cells. Salidroside-induced effects were dramatically blocked by AMPK (adenosine monophosphate-activated protein kinase) inhibitor (compound c,AMPK alpha siRNA) and by overexpression of exogenous tyrosine-phosphorylated caveolin-1 using transfected cells with phosphomimicking caveolin-1 on tyrosine 14 mutant plasmids (Y14D). Furthermore, we observed that salidroside promoted autophagosome formation via activating AMPK. Meanwhile, the interaction between caveolin-1 and LC3B-II, as well as the interaction between active Src (indicated by the phosphorylation of Src on tyrosine 416) and LC3B-II, was significantly increased, upon stimulation with salidroside. In addition, both bafilomycin A(1)(a lysosome inhibitor) and an AMPK inhibitor (compound c) markedly prevented salidroside-induced autophagic degradation of p-Src and caveolin-1. Moreover, the phosphorylation of caveolin-1 on tyrosine 14 was disrupted due to the downregulation of p-Src and caveolin-1, thereby directly decreasing LDL transcytosis by attenuating the number of caveolae on the cell membrane and by preventing caveolae-mediated LDL endocytosis released from the cell membrane. In ApoE(-/-)mice, salidroside significantly delayed the formation of atherosclerotic lesions. Meanwhile, a significant increase in LC3B, accompanied by attenuated accumulation of the autophagy substrate SQSTM1, was observed in aortic endothelium of ApoE(-/-)mice. Taken together, our findings demonstrated that salidroside protected against atherosclerosis by inhibiting LDL transcytosis through enhancing the autophagic degradation of active Src and caveolin-1.
C1 [Bai, Xiangli; Jia, Xiong; Lu, Yajing; Zhu, Lin; Zhao, Ying; Cheng, Wenzhuo; Shu, Meng; Jin, Si] Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Endocrinol,Inst Geriatr Med, Wuhan 430077, Hubei, Peoples R China.
   [Bai, Xiangli] Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Lab Med, Wuhan 430077, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Endocrinol,Inst Geriatr Med, Wuhan 430077, Hubei, Peoples R China.
EM jinsi@hust.edu.cn
RI jin, si/KGK-5977-2024
OI jin, si/0000-0003-0727-6715
FU National Natural Science Foundation of China [81573432, 81901675];
   Ministry of Education of China [NCET-10-0409]; Shanghai Municipal
   Science and Technology Commission Medical Guidance Science and
   Technology Support Project [19411968400]; Fundamental Research Funds for
   the Central Universities [2018KFYYXJJ082, 2016YXZD023, 2016YXMS128];
   Integrated Innovative Team for Major Human Diseases Program of Tongji
   Medical College, Huazhong University of Science and Technology
FX This study was supported by grants from the National Natural Science
   Foundation of China (grant numbers 81573432 and 81901675), the Ministry
   of Education of China (grant number NCET-10-0409), the Shanghai
   Municipal Science and Technology Commission Medical Guidance Science and
   Technology Support Project (19411968400), and the Fundamental Research
   Funds for the Central Universities (grant numbers 2018KFYYXJJ082,
   2016YXZD023, and 2016YXMS128). This work was supported by the Integrated
   Innovative Team for Major Human Diseases Program of Tongji Medical
   College, Huazhong University of Science and Technology.
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NR 44
TC 25
Z9 27
U1 2
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 24
PY 2020
VL 2020
AR 9595036
DI 10.1155/2020/9595036
PG 21
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MM2KC
UT WOS:000549984900001
PM 32685103
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wojdasiewicz, P
   Brodacki, S
   Cieslicka, E
   Turczyn, P
   Poniatowski, LA
   Lawniczak, W
   Olczak, M
   Stolarczyk, EU
   Wrobel, E
   Mikulska, A
   Lach-Gruba, A
   Zuk, B
   Romanowska-Próchnicka, K
   Szukiewicz, D
AF Wojdasiewicz, Piotr
   Brodacki, Stanislaw
   Cieslicka, Ewa
   Turczyn, Pawel
   Poniatowski, Lukasz A.
   Lawniczak, Weronika
   Olczak, Mieszko
   Stolarczyk, Elzbieta U.
   Wrobel, Edyta
   Mikulska, Agnieszka
   Lach-Gruba, Anna
   Zuk, Beata
   Romanowska-Prochnicka, Katarzyna
   Szukiewicz, Dariusz
TI Salidroside: A Promising Agent in Bone Metabolism Modulation
SO NUTRIENTS
LA English
DT Review
DE salidroside; osteoporosis; Rhodiola rosea; fracture healing;
   osteoarthritis; adaptogens
ID RHODIOLA-ROSEA; EXTRACT SHR-5
AB Rhodiola rosea, a long-lived herbaceous plant from the Crassulaceae group, contains the active compound salidroside, recognized as an adaptogen with significant therapeutic potential for bone metabolism. Salidroside promotes osteoblast proliferation and differentiation by activating critical signaling pathways, including bone morphogenetic protein-2 and adenosine monophosphate-activated protein kinase, essential for bone formation and growth. It enhances osteogenic activity by increasing alkaline phosphatase activity and mineralization markers, while upregulating key regulatory proteins including runt-related transcription factor 2 and osterix. Additionally, salidroside facilitates angiogenesis via the hypoxia-inducible factor 1-alpha and vascular endothelial growth factor pathway, crucial for coupling bone development with vascular support. Its antioxidant properties offer protection against bone loss by reducing oxidative stress and promoting osteogenic differentiation through the nuclear factor erythroid 2-related factor 2 pathway. Salidroside has the capability to counteract the negative effects of glucocorticoids on bone cells and prevents steroid-induced osteonecrosis. Additionally, it exhibits multifaceted anti-inflammatory actions, notably through the inhibition of tumor necrosis factor-alpha and interleukin-6 expression, while enhancing the expression of interleukin-10. This publication presents a comprehensive review of the literature on the impact of salidroside on various aspects of bone tissue metabolism, emphasizing its potential role in the prevention and treatment of osteoporosis and other diseases affecting bone physiology.
C1 [Wojdasiewicz, Piotr; Brodacki, Stanislaw; Wrobel, Edyta; Mikulska, Agnieszka; Zuk, Beata; Romanowska-Prochnicka, Katarzyna; Szukiewicz, Dariusz] Med Univ Warsaw, Fac Hlth Sci, Dept Biophys Physiol & Pathophysiol, Chalubinskiego 5, PL-02004 Warsaw, Poland.
   [Cieslicka, Ewa; Lach-Gruba, Anna] St Annas Trauma Surg Hosp, Mazovian Rehabil Ctr STOCER, Dept Rehabil, Barska 16-20, PL-02315 Warsaw, Poland.
   [Turczyn, Pawel] Eleonora Reicher Natl Inst Geriatr Rheumatol & Reh, Dept Early Arthrit, Spartanska 1, PL-02637 Warsaw, Poland.
   [Poniatowski, Lukasz A.] Dietrich Bonhoeffer Klinikum, Dept Neurosurg, Salvador Allende Str 30, D-17036 Neubrandenburg, Germany.
   [Lawniczak, Weronika] Inst Hlth Holispace, Hlth Dept, Ul Sw Wincentego 93-5, PL-03291 Warsaw, Poland.
   [Olczak, Mieszko] Med Univ Warsaw, Ctr Biostruct Res, Dept Forens Med, Oczki 1, PL-02007 Warsaw, Poland.
   [Stolarczyk, Elzbieta U.] Natl Med Inst, Spectrometr Methods Dept, 30-34 Chelmska, PL-00725 Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw; National
   Medicines Institute Lekow (NIL)
RP Szukiewicz, D (corresponding author), Med Univ Warsaw, Fac Hlth Sci, Dept Biophys Physiol & Pathophysiol, Chalubinskiego 5, PL-02004 Warsaw, Poland.
EM piotr.wojdasiewicz@wum.edu.pl; stanislaw.brodacki@wum.edu.pl;
   ew.cieslicka@gmail.com; pawel.turczyn@spartanska.pl;
   lukasz.poniatowski@gmail.com; weronika.lawniczak@holispace.com;
   e.stolarczyk@nil.gov.pl; edyta.wrobel@wum.edu.pl;
   agnieszka.mikulska@wum.edu.pl; lach.gruba@onet.pl; beata.zuk@wum.edu.pl;
   dariusz.szukiewicz@wum.edu.pl
RI Poniatowski, Łukasz/AAF-6980-2019; Romanowska-Próchnicka,
   Katarzyna/AAJ-8318-2021; Mikulska, Agnieszka/T-2070-2018; Turczyn,
   Paweł/AAT-7127-2020; Olczak, Mieszko/N-5974-2018; Szukiewicz,
   Dariusz/U-3141-2018
OI Stolarczyk, Elżbieta Urszula/0000-0002-2880-0072; Żuk,
   Beata/0000-0001-9061-1929; Mikulska, Agnieszka/0000-0002-4102-7360;
   Wojdasiewicz, Piotr/0000-0003-3309-996X; Turczyn,
   Paweł/0000-0001-6219-6422; Olczak, Mieszko/0000-0001-7055-7451;
   Szukiewicz, Dariusz/0000-0002-0124-060X
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NR 54
TC 11
Z9 15
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 15
AR 2387
DI 10.3390/nu16152387
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C2O1L
UT WOS:001287791300001
PM 39125268
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lai, WF
   He, YF
   Zhou, BB
   Wu, QQ
   Wu, HL
   Chen, JQ
   Zheng, XR
   Jia, R
   Lin, P
   Hong, GZ
   Chen, JY
AF Lai, Wenfang
   He, Yanfeng
   Zhou, Binbin
   Wu, Qingqing
   Wu, Huiling
   Chen, Jingquan
   Zheng, Xuerui
   Jia, Ru
   Lin, Pu
   Hong, Guizhu
   Chen, Jianyu
TI Salidroside facilitates neuroprotective effects in ischemic stroke by
   promoting axonal sprouting through promoting autophagy
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; Middle Cerebral Artery Occlusion; Axonal Regeneration;
   Autophagy; Neuroprotection
ID ACTIVATION; APOPTOSIS; PATHWAY
AB Background: Ischemic stroke is a common cerebrovascular disease characterized by high incidence, disability, mortality, and recurrence. The limitations of current pharmacological treatments, which have primarily single neuroprotective action and a narrow therapeutic time window, lead to unsatisfactory therapeutic efficacy. Activation of autophagy can facilitate neural regeneration. Objective: To clarify whether salidroside can promote axonal sprouting through autophagy resulting in protecting neurons. Methods: In vivo, a Middle Cerebral Artery Occlusion/reperfusion (MCAO/IR) model was used, and in vitro, an Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-induced primary neuronal cell model was employed to evaluate the neuroprotective effects of salidroside. BDA neurotracer, immunofluorescence, and Western blot (WB) were utilized to determine its impact on axonal sprouting and the levels of related proteins (MAP2, GAP43, and PSD-95). Proteomics, transmission electron microscopy (TEM), and WB were applied to identify the effects on autophagy-related proteins (beclin1, LC3, p62, and LAMP2), autophagosomes and lysosomes. The mechanism of salidroside in promoting axonal sprouting through inducing autophagy was further confirmed by blocking with the autophagy inhibitor 3-MA. Results: Salidroside reduced neurologic deficits and infarct volume induced by MCAO/IR in vivo and protected OGD/R induced primary neuronal cells in vitro. Both in vivo and in vitro, it increased the number and length of axons and upregulated the expression of key axonal proteins (MAP2, GAP43, and PSD-95) and mediated autophagy-related proteins. Mechanistic studies showed that the promoting effects of salidroside on autophagy and axonal sprouting disappeared after the blockade by 3-MA. Conclusion: This study reports for the first time that the neuroprotective effect of salidroside in ischemic stroke can be executed through mediating autophagy-related protein (beclin1, LC3, p62, and LAMP2), resulting in induced axonal sprouting or mature protein (MAP2, GAP43, and PSD-95).
C1 [Lai, Wenfang; Zhou, Binbin; Wu, Qingqing; Wu, Huiling; Chen, Jingquan; Zheng, Xuerui; Jia, Ru; Lin, Pu; Hong, Guizhu; Chen, Jianyu] Fujian Univ Tradit Chinese Med, Coll Pharmacol, 1 Qiu Yang Rd, Fuzhou 350122, Peoples R China.
   [He, Yanfeng] Fujian Med Univ, Affiliated Hosp 1, Dept Urol, Fuzhou 350005, Peoples R China.
   [He, Yanfeng] Fujian Med Univ, Affiliated Hosp 1, Natl Reg Med Ctr, Dept Urol, Binhai Campus, Fuzhou 350212, Peoples R China.
   [He, Yanfeng] Fujian Med Univ, Affiliated Hosp 1, Fujian Inst Urol, Fuzhou 350005, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian Medical
   University; Fujian Medical University; Fujian Medical University
RP Jia, R; Lin, P; Hong, GZ; Chen, JY (corresponding author), Fujian Univ Tradit Chinese Med, Coll Pharmacol, 1 Qiu Yang Rd, Fuzhou 350122, Peoples R China.
EM 4812613@qq.com; 65232150@qq.com; guizhuhong@fjtcm.edu.cn;
   chenjianyu122@163.com
FU National Natural Science Foundation of China [82174001, 81973503];
   Fujian Provincial Department of Science and Technology, China
   [2021J02014, 2020J01727]; Foundation of Fujian University of Traditional
   Chinese Medicine [XJC2023012]; NATCMs Project of High-level Construction
   of Key TCM Traditional Disciplines (Traditional Chinese Orthopedics)
   Chinese Orthopedics Open subject of FJTCM [zyyzdxk-2023106, XGS2023005]
FX This work was supported by the National Natural Science Foundation of
   China (Project 82174001 and 81973503) and by Fujian Provincial
   Department of Science and Technology, China (Project 2021J02014 and
   2020J01727). Foundation of Fujian University of Traditional Chinese
   Medicine (No. XJC2023012), NATCMs Project of High-level Construction of
   Key TCM Traditional Disciplines (Traditional Chinese Orthopedics)
   Chinese Orthopedics Open subject of FJTCM (Grant number:
   zyyzdxk-2023106, XGS2023005). The authors thank the staff in the Animal
   Center of the Fujian University of Traditional Chinese Medicine for
   their technical support.
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NR 50
TC 17
Z9 19
U1 7
U2 24
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD DEC
PY 2024
VL 135
AR 156208
DI 10.1016/j.phymed.2024.156208
EA NOV 2024
PG 18
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA M8E4A
UT WOS:001359806900001
PM 39550919
DA 2026-05-27
ER

PT J
AU Zhang, ZD
   Cao, MY
   Du, YX
   Wang, PY
   Hou, XR
   Wang, XP
AF Zhang, Zhendong
   Cao, Mingyuan
   Du, Yuxin
   Wang, Pingyi
   Hou, Xinrui
   Wang, Xiaoping
TI Salidroside suppresses gastric cancer progression via
   miR-1343-3p-mediated repression of ACOT11 and disruption of fatty acid
   metabolism
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE gastric cancer; salidroside; lipid metabolism; miR-1343-3p; ACOT11
ID LIPID-METABOLISM; CELLS; PROLIFERATION; MIGRATION; METASTASIS; INVASION
AB Objective Salidroside, a bioactive compound derived from Rhodiola, has been demonstrated to upregulate the tumor suppressor miR-1343-3p, leading to suppression of gastric cancer growth. However, the precise molecular mechanisms underlying salidroside-mediated regulation of lipid metabolism via miR-1343-3p and its downstream mRNA targets remain poorly understood.Methods The interaction between miR-1343-3p and ACOT11 was evaluated through Pearson correlation analysis, sequence-based binding site alignment, and RNA immunoprecipitation (RIP) assays. The effects of salidroside treatment on cell proliferation, gene and protein expression, downstream metabolites, and energy production were assessed through a series of in vitro and in vivo experiments, including the CCK-8 assay, colony formation assay, RT-qPCR, Western blot, ELISA, cell transfection, and xenograft tumor models.Results The expression of miR-1343-3p is negatively correlated with ACOT11 mRNA, which is closely associated with lipid metabolism. Salidroside significantly inhibits the proliferation of gastric cancer cells in a dose-dependent manner. Compared to untreated controls, salidroside-treated gastric cancer cells showed decreased ACOT11 mRNA/protein expression but increased miR-1343-3p levels. This was accompanied by elevated substrate fatty acyl-CoA concentrations with concurrent reductions in acetyl-CoA, FFA, and ATP. ACOT11 is a downstream target of miR-1343-3p, up-regulating miR-1343-3p expression reduces ACOT11 expression, while down-regulating miR-1343-3p expression increases ACOT11 expression. In vivo, salidroside significantly inhibited tumor growth in gastric cancer xenograft models.Conclusions We demonstrate that salidroside exerts anti-proliferative effects in gastric cancer by targeting the miR-1343-3p/ACOT11/FFA lipid metabolism signaling pathway, disrupting cancer cell energy production. These regulatory factors hold promise as novel therapeutic targets for gastric cancer.
C1 [Zhang, Zhendong; Cao, Mingyuan; Du, Yuxin; Wang, Pingyi; Hou, Xinrui; Wang, Xiaoping] Xizang Minzu Univ, Sch Med, Xianyang, Shaanxi, Peoples R China.
   [Zhang, Zhendong; Cao, Mingyuan; Du, Yuxin; Hou, Xinrui; Wang, Xiaoping] Xizang Minzu Univ, Key Lab High Altitude Hypoxia Environm & Life Hlth, Xianyang, Shaanxi, Peoples R China.
   [Wang, Pingyi] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Rehabil Med, Guangzhou, Guangdong, Peoples R China.
C3 Xizang Minzu University; Xizang Minzu University; Sun Yat Sen University
RP Wang, XP (corresponding author), Xizang Minzu Univ, Sch Med, Xianyang, Shaanxi, Peoples R China.; Wang, XP (corresponding author), Xizang Minzu Univ, Key Lab High Altitude Hypoxia Environm & Life Hlth, Xianyang, Shaanxi, Peoples R China.
EM xpwang@xzmu.edu.cn
RI cao, mingyuan/IRZ-1013-2023; du, yuxin/IAP-7044-2023
FU National Natural Science Foundation of China [82460515]; Natural Science
   Basic Research Plan of Shaanxi Province [2025JC-YBMS-1088]; Central
   Guidance on Local Science and Technology Development Fund of Xizang
   Autonomous Region [LSKJ202447]; Key R&D Projects of Xianyang Municipal
   Science and Technology Programme [L2024-ZDYF-SF-0025]; Graduate research
   innovation and practice projects of Xizang Minzu University [Y2025140]
FX The author(s) declare financial support was received for the research
   and/or publication of this article. This work was supported by the
   National Natural Science Foundation of China (grant number 82460515),
   the Natural Science Basic Research Plan of Shaanxi Province (grant
   number 2025JC-YBMS-1088), the Central Guidance on Local Science and
   Technology Development Fund of Xizang Autonomous Region (grant number
   LSKJ202447), the Key R&D Projects of Xianyang Municipal Science and
   Technology Programme (grant number L2024-ZDYF-SF-0025) and the Graduate
   research innovation and practice projects of Xizang Minzu University
   (grant number Y2025140).
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NR 46
TC 2
Z9 2
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD SEP 4
PY 2025
VL 15
AR 1651857
DI 10.3389/fonc.2025.1651857
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 7JX2Y
UT WOS:001572780800001
PM 40978035
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lin, SSC
   Chin, LW
   Chao, PC
   Lai, YY
   Lin, LY
   Chou, MY
   Chou, MC
   Wei, JCC
   Yang, CC
AF Lin, Shih-Shen Chou
   Chin, Lengsu William
   Chao, Pei-Chun
   Lai, Ya-Yun
   Lin, Long-Yau
   Chou, Ming-Yung
   Chou, Ming-Chih
   Wei, James Cheng-Chung
   Yang, Chi-Chiang
TI In Vivo Th1 and Th2 Cytokine Modulation Effects of Rhodiola
   rosea Standardised Solution and its Major Constituent, Salidroside
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Rhodiola rosea; cytokine; ELISA; Th1; Th2
ID L. EXTRACT; BALB/C MICE; VITRO; RESISTANCE; PROTEIN; STRESS; KINASE;
   CELLS
AB Although Rhodiola rosea (L.) is used widely and disseminated in Oriental medicine, its in vivo effects on cytokine modulation remain unclear. Among the biologically active components of Rhodiola rosea, salidroside was suggested to be the most active compound. The objectives of this study were to assess the toxicity and cytokine modulation effects of Rhodiola rosea standardised solution (RRSS) and salidroside. Quantitative high pressure liquid chromatography (HPLC) analysis determined the content of salidroside in RRSS to be 4.39% (w/v). Groups of Balb/c mice were fed daily with different doses of RRSS or salidroside, with CAPE or distilled water used as positive and negative controls, respectively. The acute and subacute toxicity tests did not reveal weight differences, pathological changes, or abnormalities in liver or kidney function indices among the treated groups. Ovalbumin-primed mouse cytokine assays demonstrated that both T helper (Th1) (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) cytokines were significantly increased by feeding with RRSS in a dose-and time-dependent manner (p < 0.05). Moreover, the cytokine modulation effects of salidroside were less prominent than that of RRSS treatment and not dose-dependent. These findings suggest that increased secretion of both Th1- and Th2-pattern cytokines can be achieved with RRSS and salidroside treatment. Copyright (C) 2011 John Wiley & Sons, Ltd.
C1 [Yang, Chi-Chiang] Chung Shan Med Univ, Sch Med Lab & Biotechnol, Taichung 40201, Taiwan.
   [Lin, Shih-Shen Chou; Chou, Ming-Chih] Chung Shang Med Univ, Sch Dent, Taichung, Taiwan.
   [Chin, Lengsu William; Chou, Ming-Chih; Yang, Chi-Chiang] Chung Shan Med Univ, Inst Med, Taichung 40201, Taiwan.
   [Chin, Lengsu William; Lin, Long-Yau; Wei, James Cheng-Chung] Da Chien Gen Hosp, Emergency Dept, Miaoli, Taiwan.
   [Chao, Pei-Chun] Chung Shan Med Univ, Sch Nutr Sci, Taichung 40201, Taiwan.
   [Chao, Pei-Chun] Chung Shan Med Univ Hosp, Dept Nutr, Taichung, Taiwan.
   [Lai, Ya-Yun] Chung Shan Med Univ, Dept Appl Chem, Taichung 40201, Taiwan.
   [Wei, James Cheng-Chung] Chung Shan Med Univ Hosp, Div Allergy Immunol & Rheumatol, Taichung, Taiwan.
   [Yang, Chi-Chiang] Chung Shan Med Univ Hosp, Dept Clin Lab, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University; Chung Shan Medical University Hospital; Chung Shan Medical
   University; Chung Shan Medical University; Chung Shan Medical University
   Hospital; Chung Shan Medical University; Chung Shan Medical University
   Hospital
RP Yang, CC (corresponding author), Chung Shan Med Univ, Sch Med Lab & Biotechnol, 110,Sect 1,Chien Kuo N Rd, Taichung 40201, Taiwan.
EM cyang@csmu.edu.tw
RI Wei, James Cheng-Chung/AAL-8947-2020
OI Wei, James Cheng-Chung/0000-0002-1235-0679
FU Chung Shan Medical University [CSMU-96-OM-B-021]; National Science
   Council; Ministry of Education
FX This study was funded by a grant from the Chung Shan Medical University
   (CSMU-96-OM-B-021). Microplate analysis was performed in the Instrument
   Centre of Chung Shan Medical University, which is supported by the
   National Science Council, Ministry of Education, and Chung Shan Medical
   University.
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NR 37
TC 13
Z9 19
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2011
VL 25
IS 11
BP 1604
EP 1611
DI 10.1002/ptr.3451
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 851XY
UT WOS:000297307000004
PM 21394811
DA 2026-05-27
ER

PT J
AU Li, PP
AF Li, Pingping
TI Synthesis of eutigoside C based on salidroside
SO INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
LA English
DT Article
DE Eutigoside C; Salidroside; Phenylethanoid glycosides; Semi-synthetic
ID PHENYLETHANOID GLYCOSIDES; EURYA-EMARGINATA
AB Eutigoside C has been synthesized starting from commercially available salidroside through a linear reaction sequence of 2 steps with an overall yield of 65.6%. This approach involves selective hydroxy esterification and phenolic hydroxyl oxidation. Up to 11g of eutigoside C was achieved by this new simple and efficient semi-synthetic strategy, that laid a solid material foundation for further investigation of biological activity
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RP Li, PP (corresponding author), Dongying Vocat Inst, Coll Petr & Chem Engn, Dept Prod Operat & Proc Teaching, Dongying, Peoples R China.
EM dysyhglpp@163.com
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NR 14
TC 0
Z9 0
U1 0
U2 2
PU CONNECT JOURNALS
PI GHAZIABAD
PA D-189 RAMPRATSHA, PO CHANDER NAGAR, GHAZIABAD, 201 011, INDIA
SN 0971-1627
EI 2456-4311
J9 INDIAN J HETEROCY CH
JI Indian J. Heterocycl. Chem.
PD JUL-SEP
PY 2024
VL 34
IS 3
BP 369
EP 372
DI 10.59467/IJHC.2024.34.369
PG 4
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA N0B3G
UT WOS:001361083800013
DA 2026-05-27
ER

PT J
AU Zheng, T
   Bian, F
   Chen, L
   Wang, QB
   Jin, S
AF Zheng, Tao
   Bian, Fang
   Chen, Li
   Wang, Qibin
   Jin, Si
TI Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential
   Role of AMP-Activated Protein Kinase
SO MOLECULAR DIAGNOSIS & THERAPY
LA English
DT Review
ID INDUCED OXIDATIVE STRESS; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS;
   LIPID-METABOLISM; SKELETAL-MUSCLE; ETHANOL EXTRACT; GLUCOSE; CRENULATA;
   ROSEA; ATHEROSCLEROSIS
AB Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-beta-glucoside compound, is the main active ingredient of the Rhodiola root. Recently, various studies have suggested that Rhodiola and salidroside may have pharmacological properties that could be used in the treatment of diabetes, as studies have confirmed that AMP-activated protein kinase (AMPK) and AMPK-related signaling are connected with its beneficial effects. This review aims to summarize the research progress of Rhodiola and salidroside in the treatment of diabetes. A detailed summary of AMPK and AMPK-related signaling induced by Rhodiola and salidroside are discussed.
C1 [Zheng, Tao; Chen, Li; Wang, Qibin] Hubei Univ Med, Taihe Hosp, Inst Wudang Tradit Chinese Med, Shiyan, Hubei, Peoples R China.
   [Bian, Fang] Hubei Univ Arts & Sci, Affiliated Hosp, Xiangyang Cent Hosp, Dept Pharm, Xiangyang, Hubei, Peoples R China.
   [Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Arts & Science;
   Huazhong University of Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM jinsi@mails.tjmu.edu.cn
RI jin, si/KGK-5977-2024; Zheng, Tao/JOZ-1467-2023
OI jin, si/0000-0003-0727-6715; Zheng, Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81703582, 81573432,
   81503072, 81373413]; Ministry of Education of China [NCET-10-0409];
   Hubei Provincial Natural Science Foundation of China [2016CFB153]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81703582, 81573432, 81503072 and 81373413),
   Ministry of Education of China (NCET-10-0409), and Hubei Provincial
   Natural Science Foundation of China (2016CFB153).
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NR 89
TC 37
Z9 44
U1 3
U2 59
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1177-1062
EI 1179-2000
J9 MOL DIAGN THER
JI Mol. Diagn. Ther.
PD AUG
PY 2019
VL 23
IS 4
BP 489
EP 498
DI 10.1007/s40291-019-00402-4
PG 10
WC Genetics & Heredity; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Pharmacology & Pharmacy
GA IN4ZN
UT WOS:000478685800004
PM 31069710
DA 2026-05-27
ER

PT J
AU Bai, YF
   Bi, HP
   Zhuang, YB
   Liu, C
   Cai, T
   Liu, XN
   Zhang, XL
   Liu, T
   Ma, YH
AF Bai, Yanfen
   Bi, Huiping
   Zhuang, Yibin
   Liu, Chang
   Cai, Tao
   Liu, Xiaonan
   Zhang, Xueli
   Liu, Tao
   Ma, Yanhe
TI Production of salidroside in metabolically engineered Escherichia
   coli
SO SCIENTIFIC REPORTS
LA English
DT Article
ID L-TYROSINE PRODUCTION; MICROBIAL-PRODUCTION; MOLECULAR-CLONING;
   SALICYLIC-ACID; CAFFEIC ACID; PATHWAY; BIOSYNTHESIS; EXPRESSION;
   GLUCOSYLTRANSFERASE; DEHYDROGENASE
AB Salidroside (1) is the most important bioactive component of Rhodiola (also called as "Tibetan Ginseng''), which is a valuable medicinal herb exhibiting several adaptogenic properties. Due to the inefficiency of plant extraction and chemical synthesis, the supply of salidroside (1) is currently limited. Herein, we achieved unprecedented biosynthesis of salidroside (1) from glucose in a microorganism. First, the pyruvate decarboxylase ARO10 and endogenous alcohol dehydrogenases were recruited to convert 4-hydroxyphenylpyruvate (2), an intermediate of L-tyrosine pathway, to tyrosol (3) in Escherichia coli. Subsequently, tyrosol production was improved by overexpressing the pathway genes, and by eliminating competing pathways and feedback inhibition. Finally, by introducing Rhodiola-derived glycosyltransferase UGT73B6 into the above-mentioned recombinant strain, salidroside (1) was produced with a titer of 56.9 mg/L. Interestingly, the Rhodiola-derived glycosyltransferase, UGT73B6, also catalyzed the attachment of glucose to the phenol position of tyrosol (3) to form icariside D2 (4), which was not reported in any previous literatures.
C1 [Bai, Yanfen; Bi, Huiping; Zhuang, Yibin; Liu, Chang; Cai, Tao; Liu, Xiaonan; Zhang, Xueli; Liu, Tao; Ma, Yanhe] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.
   [Bai, Yanfen; Bi, Huiping; Zhuang, Yibin; Liu, Chang; Liu, Xiaonan; Zhang, Xueli; Liu, Tao] Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
   [Bai, Yanfen; Liu, Chang; Liu, Xiaonan] Univ Chinese Acad Sci, Beijing, Peoples R China.
C3 Chinese Academy of Sciences; Tianjin Institute of Industrial
   Biotechnology, CAS; Chinese Academy of Sciences; Chinese Academy of
   Sciences; University of Chinese Academy of Sciences, CAS
RP Liu, T (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.
EM liu_t@tib.cas.cn
RI Liu, Chang/OBO-3125-2025; tao, cai/LXU-6333-2024
OI 张, 学礼/0000-0002-8660-4037
FU 973 Program of China [2012CB721100]; 863 Program of China
   [2012AA02A704]; Sciences and Technology Planning projects of Tianjin
   city [13ZCZDSY05100]; National Natural Science Foundation of China
   [31300040, 21302214]; 100 Talents Program of the Chinese Academy of
   Sciences
FX This work was supported by grants from the 973 Program of China
   (2012CB721100), the 863 Program of China (2012AA02A704), the Sciences
   and Technology Planning projects of Tianjin city (13ZCZDSY05100), the
   National Natural Science Foundation of China (31300040 and 21302214).
   Tao Liu was supported by the 100 Talents Program of the Chinese Academy
   of Sciences.
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NR 45
TC 87
Z9 118
U1 3
U2 178
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 17
PY 2014
VL 4
AR 6640
DI 10.1038/srep06640
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AR0WJ
UT WOS:000343293800001
PM 25323006
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yi, Y
   He, P
   Zhang, LC
AF Yi, Yan
   He, Ping
   Zhang, Lianchang
TI Magnetic Solid Phase Extraction for Rapid Determination of Salidroside
   and its Metabolite p-Tyrosol in Human Plasma by UPLC-MS/MS
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE human plasma; magnetic solid-phase extraction; multi-walled carbon
   nanotubes; p-tyrosol; salidroside; UPLC-MS/MS
ID WALLED CARBON NANOTUBES; SAMPLES
AB A new approach of magnetic solid phase extraction (MSPE) coupled with ultra high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed for the extraction and determination of salidroside and p-tyrosol using multi-walled carbon nanotubes-coated magnetic Fe3O4 nanoparticles (Fe3O4-MWCNTs) as the MSPE absorbent. Some important experimental parameters that could influence the extraction efficiency were investigated in detail. Under optimized conditions, the detection limit (LOD) of the method was 11.9 and 7.1 ng/mL for salidroside and p-tyrosol, respectively, and the calibration curves were linear (r >= 0.995) over the concentration ranges from 50 to 1000 ng/mL. This MSPE method has been successfully applied for the determination of salidroside and p-tyrosol in human plasma with the recoveries of 92.5-98.2% for the spiked samples. Taken together, the MSPE method developed in current study provides a new option for the determination of salidroside and p-tyrosol in human plasma.
C1 [Yi, Yan; He, Ping; Zhang, Lianchang] Kunming Univ, Kunming 650214, Yunnan, Peoples R China.
C3 Kunming University
RP Yi, Y (corresponding author), Kunming Univ, Kunming 650214, Yunnan, Peoples R China.
EM 3223247480@qq.com
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NR 28
TC 1
Z9 1
U1 1
U2 7
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2019
VL 38
IS 1
BP 191
EP 197
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HL4YZ
UT WOS:000458733500029
DA 2026-05-27
ER

PT J
AU Liu, HQ
   Zhang, TX
AF Liu, Huiqiong
   Zhang, Tianxiao
TI Protective effect of salidroside on lung injury in mice with Poly(I:
   C)-Induced viral pneumonia based on the TLR4/MyD88/NF-κB signaling
   pathway
SO JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
LA English
DT Article
DE Viral pneumonia; Salidroside; Anti-inflammation; Antioxidation
ID TRADITIONAL CHINESE MEDICINE; PATHOGENESIS
AB Objective: This study aimed to explore the protective effect of salidroside on lung injury in a mouse model of viral pneumonia (VP), and comprehensively elucidating its potential underlying mechanisms. Methods: This study successfully established a VP model in mice by intratracheal instillation of Poly (I:C). Mice were divided into different groups, including the control group, model group, low, medium, and high dose treatment groups of salidroside, and positive control group. Lung injury was evaluated by measuring protein levels in lung wet/dry weight ratio; using H&E staining technology to visually observe the pathological changes in lung tissue; using ELISA to detect levels of inflammatory cytokines; measuring oxidative stress markers in lung tissue; and utilizing Western blot to analyze the expression of signaling pathway related proteins. Results: Compared to the model group, salidroside showed better lung protective effects as revealed by significantly reduced lung wet/dry weight ratio, inflammation, and oxidative stress. Salidroside also inhibited the activation of related TLR4/MyD88/NF-kappa B signaling pathways. Among all dose groups, the high-dose group showed the most significant lung protective effect. Conclusion: Salidroside exerts protective effects by inhibiting TLR4/MyD88/NF-kappa B pathway activation, consequently reducing inflammation and oxidative stress markers and providing a solid theoretical basis for the potential clinical application of this drug in the treatment of VP.
C1 [Zhang, Tianxiao] Peoples Hosp Cangnan, Dept Infect Dis, Wenzhou 325800, Zhejiang, Peoples R China.
   [Liu, Huiqiong] Peoples Hosp Cangnan, Dept Pediat, Wenzhou 325800, Zhejiang, Peoples R China.
RP Zhang, TX (corresponding author), 2288 Yuchang Rd, Lingxi Town, Wenzhou 325800, Zhejiang, Peoples R China.
EM siqizh@163.com
FU Wenzhou Scientific Research Project [Y20240155]
FX <BOLD>Funding</BOLD> This work was supported by grants from the Wenzhou
   Scientific Research Project [grant number Y20240155] .
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NR 32
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1687-8507
J9 J RADIAT RES APPL SC
JI J. Radiat. Res. Appl. Sci.
PD SEP
PY 2025
VL 18
IS 3
AR 101741
DI 10.1016/j.jrras.2025.101741
EA JUL 2025
PG 8
WC Multidisciplinary Sciences; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Radiology, Nuclear Medicine &
   Medical Imaging
GA 4XL1T
UT WOS:001528973500001
OA gold
DA 2026-05-27
ER

PT J
AU Xing, Y
   Wei, RB
   Tang, L
   Yang, Y
   Zheng, XY
   Wang, ZC
   Gao, YW
AF Xing Yue
   Wei Ri-bao
   Tang Lu
   Yang Yue
   Zheng Xiao-yong
   Wang Zi-cheng
   Gao Yu-wei
TI Protective effect of salidroside on contrast-induced nephropathy in
   comparison with N-acetylcysteine and its underlying mechanism
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE salidroside; contrast-induced-nephropathy; oxidative stress;
   N-acetylcysteine; Chinese medicine
ID INDUCED OXIDATIVE STRESS; RAT MODEL; PATHOPHYSIOLOGY; RHODIOLA; INJURY;
   CELL
AB To study the prevention effect of salidroside on contrast-induced-nephropathy (CIN) and its underlying mechanism.
   A total of 24 Wistar rats were randomly divided into 4 groups with 6 in each group. Rats were firstly administrated with normal saline (control and model groups), N-acetylcysteine (NAC, NAC group) and salidroside (salidroside group) for 7 days before model establishment in each group, respectively. Histopathological analysis was performed by periodic acid-Schiff (PAS) staining. Oxidative stress related parameters including superoxide dismutase (SOD) and methane dicarboxylic aldehyde (MDA), nitric oxide (NO), angiotensin II (Ang II), 8-hydroxy-2'-deoxyguanosine (8-OHdG), mRNA and protein levels of endothelial nitric oxide synthase (eNOS), and nitric oxide synthase (NOS) activity were measured.
   Compared with the control group, the levels of MDA, Ang II and 8-OHdG were all significantly increased and levels of SOD, NO, and eNOS mRNA and protein were decreased significantly in the model group (P < 0.05). Meanwhile, the NOS activity was also significantly decreased in the model group (P < 0.05). In addition, the levels of these parameters were all improved in the NAC (P < 0.05) and salidroside groups and no significant different was found between these two groups (P > 0.05).
   Salidroside can be the potential substitute of NAC to prevent CIN. The underlying mechanism may be associated with oxidative stress damage caused by contrast agents.
C1 [Xing Yue; Wei Ri-bao; Yang Yue; Zheng Xiao-yong; Wang Zi-cheng; Gao Yu-wei] Chinese Peoples Liberat Army Gen Hosp, State Discipline, Beijing 100853, Peoples R China.
   [Xing Yue; Wei Ri-bao; Yang Yue; Zheng Xiao-yong; Wang Zi-cheng; Gao Yu-wei] Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China.
   [Tang Lu] Tianjin First Ctr Hosp, Dept Rheumatism Immun, Tianjin 300192, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Wei, RB (corresponding author), Chinese Peoples Liberat Army Gen Hosp, State Discipline, 2011DAV00088, Beijing 100853, Peoples R China.
EM wrbbj2006@126.com
RI Gao, Yuwei/ODJ-8552-2025
FU National Nature Science Foundation of China [81273968, 81471027];
   Ministerial Project of the National Working Commission on Aging
   [QLB2014W002]
FX Supported by the National Nature Science Foundation of China (No.
   81273968 and No. 81471027), and Ministerial Project of the National
   Working Commission on Aging (No. QLB2014W002)
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NR 30
TC 15
Z9 17
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD APR
PY 2015
VL 21
IS 4
BP 266
EP 273
DI 10.1007/s11655-015-2137-y
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CF9XE
UT WOS:000352919700005
PM 25877653
DA 2026-05-27
ER

PT J
AU Wang, CJ
   Nan, XD
   Pei, SY
   Zhao, Y
   Wang, XK
   Ma, SJ
   Ma, GY
AF Wang, Chenjing
   Nan, Xiaodong
   Pei, Shuyan
   Zhao, Yu
   Wang, Xiaokun
   Ma, Shijie
   Ma, Guoyan
TI Salidroside and isorhamnetin attenuate urotensin II-induced inflammatory
   response in vivo and in vitro: Involvement in regulating
   the RhoA/ROCK II pathway
SO ONCOLOGY LETTERS
LA English
DT Article
DE salidroside; isorhamnetin; urotensin II; inflammatory response;
   atherosclerosis; Ras homolog gene family; member A; Rho kinases II
   pathway
AB Urotensin II (UII), a vital vasoconstrictor peptide, causes an inflammatory response in the pathogenesis of atherosclerosis. Previous studies have reported that the Ras homolog gene family, member A (RhoA)/Rho kinases (ROCK) pathway modulates the inflammatory response of the atherosclerotic process. However, to the best of our knowledge, whether the RhoA/ROCK pathway mediates the inflammatory effect of UII has not been previously elucidated. Salidroside and isorhamnetin are two early developed antioxidant Tibetan drugs, both displaying cardioprotective effects against atherosclerosis. Therefore, the aim of the present study was to investigate the protective effects of salidroside, isorhamnetin or combination of these two drugs on the UII-induced inflammatory response in vivo (rats) or in vitro [primary vascular smooth muscle cells (VSMCs)], as well as to examine the role of the RhoA/ROCK pathway in these processes. The levels of inflammatory markers were measured via ELISA. The mRNA and protein expression levels of RhoA and ROCK II were detected using reverse transcription-quantitative PCR assay and western blot analysis. It was demonstrated that salidroside, isorhamnetin and both in combination decreased the levels of the serum pro-inflammatory cytokines TNF-alpha and IL-1 beta, as well as increased the levels of the anti-inflammatory cytokine IL-10 and macrophage migration inhibitory factor in rats with subacute infusion of UII and in the culture supernatant from primary VSMCs-exposed to UII. Moreover, salidroside, isorhamnetin and both in combination attenuated the mRNA and protein expression levels of RhoA and ROCK II in vivo and in vitro, at concentrations corresponding to human therapeutic blood plasma concentrations. Thus, these drugs could inhibit the RhoA/ROCK II pathway under UII conditions. The combination of salidroside and isorhamnetin did not display a stronger inhibitory effect on the inflammatory response and the RhoA/ROCK II pathway compared with salidroside and isorhamnetin in isolation. Collectively, the results indicated that salidroside, isorhamnetin and both in combination inhibited the RhoA/ROCK II pathway, which then attenuated the inflammatory response under UII-induced conditions, resulting in cardioprotection in atherosclerosis.
C1 [Wang, Chenjing; Pei, Shuyan; Zhao, Yu; Wang, Xiaokun; Ma, Shijie; Ma, Guoyan] Northwest Minzu Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, 1 XibeiXincun, Lanzhou 730030, Gansu, Peoples R China.
   [Nan, Xiaodong] Gansu Prov Corps Hosp Chinese Peoples Armed Polic, Intens Care Unit, Lanzhou 730050, Gansu, Peoples R China.
C3 Northwest Minzu University
RP Wang, CJ (corresponding author), Northwest Minzu Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, 1 XibeiXincun, Lanzhou 730030, Gansu, Peoples R China.
EM wangcj01002@163.com
RI pei, shuyan/JTU-0456-2023
FU National Natural Science Foundation of China [81360490]; research funds
   for Institutions of Higher Learning of Gansu Province [2017B-81];
   Fundamental Research Funds for the Central Universities [31920180023,
   31920190106]; Natural Science Foundation of Gansu Province, China
   [20JR5RA503]
FX Not applicable.The present study was supported by grants from National
   Natural Science Foundation of China (grant no. 81360490), research funds
   for Institutions of Higher Learning of Gansu Province (grant no.
   2017B-81), the Fundamental Research Funds for the Central Universities
   (grant nos. 31920180023 and 31920190106) and the Natural Science
   Foundation of Gansu Province, China (grant no. 20JR5RA503).
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NR 53
TC 10
Z9 12
U1 0
U2 44
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD APR
PY 2021
VL 21
IS 4
AR 292
DI 10.3892/ol.2021.12553
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QM7EK
UT WOS:000621938100001
PM 33732368
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zheng, JB
   Zhang, JZ
   Han, J
   Zhao, ZC
   Lin, K
AF Zheng, Jiabing
   Zhang, Jizhou
   Han, Jing
   Zhao, Zhichang
   Lin, Kan
TI The effect of salidroside in promoting endogenous neural regeneration
   after cerebral ischemia/reperfusion involves notch signaling pathway and
   neurotrophic factors
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Salidroside; Cerebral ischemia/reperfusion; Ischemic stroke; Neural
   regeneration; Notch signaling pathway; BDNF
ID MESENCHYMAL STEM-CELLS; ISCHEMIC BRAIN-INJURY; REACTIVE ASTROCYTES;
   RECOVERY; PROTEIN; MICE; NEUROGENESIS; NEURONS; STROKE; ROLES
AB BackgroundSalidroside is the major bioactive and pharmacological active substance in Rhodiola rosea L. It has been reported to have neuroprotective effects on cerebral ischemia/reperfusion (I/R). However, whether salidroside can enhance neural regeneration after cerebral I/R is still unknown. This study investigated the effects of salidroside on the endogenous neural regeneration after cerebral I/R and the related mechanism.MethodsFocal cerebral I/R was induced in rats by transient middle cerebral artery occlusion/reperfusion (MCAO/R). The rats were intraperitoneally treated salidroside once daily for 7 consecutive days. Neurobehavioral assessments were performed at 3 days and 7 days after the injury. TTC staining was performed to assess cerebral infarct volume. To evaluate the survival of neurons, immunohistochemical staining of Neuronal Nuclei (NeuN) in the ischemic hemisphere were conducted. Also, immunofluorescence double or triple staining of the biomarkers of proliferating neural progenitor cells in Subventricular Zone (SVZ) and striatum of the ischemia hemisphere were performed to investigate the neurogenesis. Furthermore, reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) were used to detect the expression of neurotrophic factors (NTFs) brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Expression of Notch1 and its target molecular Hes1 were also analyzed by western-blotting and RT-PCR.ResultsSalidroside treatment ameliorated I/R induced neurobehavioral impairment, and reduced infarct volume. Salidroside also restored NeuN positive cells loss after I/R injury. Cerebral I/R injury significantly increased the expression of 5-Bromo-2'-Deoxyuridine (BrdU) and doublecotin (DCX), elevated the number of BrdU/Nestin/DCX triple-labeled cells in SVZ, and BrdU/Nestin/glial fibrillary acidic protein (GFAP) triple-labeled cells in striatum. Salidroside treatment further promoted the proliferation of BrdU/DCX labeled neuroblasts and BrdU/Nestin/GFAP labeled reactive astrocytes. Furthermore, salidroside elevated the mRNA expression and protein concentration of BDNF and NGF in ischemia periphery area, as well. Mechanistically, salidroside elevated Notch1/Hes1 mRNA expression in SVZ. The protein levels of them were also increased after salidroside administration.ConclusionsSalidroside enhances the endogenous neural regeneration after cerebral I/R. The mechanism of the effect may involve the regulation of BDNF/NGF and Notch signaling pathway.
C1 [Zheng, Jiabing; Zhao, Zhichang; Lin, Kan] Fujian Med Univ, Union Hosp, Fuzhou, Fujian, Peoples R China.
   [Zhang, Jizhou; Han, Jing] Fujian Acad Chinese Med Sci, Inst Mat Med, Fuzhou, Fujian, Peoples R China.
C3 Fujian Medical University
RP Lin, K (corresponding author), Fujian Med Univ, Union Hosp, Fuzhou, Fujian, Peoples R China.
EM linkan800816@outlook.com
RI /N-8928-2019
FU Natural Science Foundation of Fujian Province of China
FX We want to thank Pro. Minxia Wu of Fujian Medical University for her
   help in laser confocal image analysis.
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NR 58
TC 19
Z9 23
U1 3
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD AUG 1
PY 2024
VL 24
IS 1
AR 293
DI 10.1186/s12906-024-04597-w
PG 15
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA A8O6W
UT WOS:001285081300001
PM 39090706
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gao, H
   Liu, XP
   Tian, KM
   Meng, YC
   Yu, CC
   Peng, YF
AF Gao, Hui
   Liu, Xueping
   Tian, Kunming
   Meng, Yichong
   Yu, Cuicui
   Peng, Yingfu
TI RETRACTED: Insight into the Protective Effect of Salidroside against
   H2O2-Induced Injury in H9C2 Cells (Retracted
   Article)
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article; Retracted Publication
ID INDUCED MYOCARDIAL INJURY; OXIDATIVE STRESS; TOTAL FLAVONOIDS; IN-VITRO;
   BCL-2; POLYPHENOLS; DYSFUNCTION; ACTIVATION; APOPTOSIS; HEART
AB Salidroside is the important active ingredient of Rhodiola species, which shows a wide range of pharmacological activities such as antioxidative stress, anti-inflammation, and antiliver fibrosis. In this paper, we aimed to study the protective effect and mechanism of salidroside against H2O2-induced oxidative damage in H9C2 cells by determining cell proliferation rate, intracellular reactive oxygen species (ROS) level, antioxidant enzyme activities, and the expression of apoptosis-related proteins. The results showed that salidroside significantly alleviated cell growth inhibition induced by H2O2 treatment in H9C2 cells, decreased the levels of intracellular ROS and malondialdehyde (MDA), and increased the activity of superoxide dismutase (SOD) and catalase (CAT); meanwhile, salidroside upregulated the expression of Bcl-2 while downregulated the expression of Bax, p53, and caspase-3 in H2O2-treated H9C2 cells. Furthermore, the antiapoptotic effect of salidroside was almost eliminated by the knockdown of Bcl-2. In the further exploration, the Bcl-2 expression was decreased by the p53 overexpression and increased by p53 knockdown in H2O2-treated H9C2 cells. Consequently, salidroside could protect H9C2 cells against H2O2-induced oxidative damage, and the underlying mechanism may be related to scavenging intracellular ROS, increasing the activities of intracellular antioxidant enzymes and inhibiting the expression of apoptosis-related proteins.
C1 [Gao, Hui; Meng, Yichong] Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing 312000, Peoples R China.
   [Gao, Hui; Peng, Yingfu] Jishou Univ, Sch Med, Dept Pharmacol, Jishou 416000, Peoples R China.
   [Liu, Xueping] Guangxi Univ Sci & Technol, Sch Med, Dept Pharmacol, Liuzhou 545006, Peoples R China.
   [Tian, Kunming] Zunyi Med Univ, Dept Environm Tox, Zunyi 563006, Peoples R China.
   [Yu, Cuicui] Tibet Agr Sci & Technol Innovat Pk, Lhasa 850000, Xizang, Peoples R China.
C3 Shaoxing University; Jishou University; Guangxi University of Science &
   Technology; Zunyi Medical University
RP Gao, H (corresponding author), Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing 312000, Peoples R China.; Gao, H; Peng, YF (corresponding author), Jishou Univ, Sch Med, Dept Pharmacol, Jishou 416000, Peoples R China.; Yu, CC (corresponding author), Tibet Agr Sci & Technol Innovat Pk, Lhasa 850000, Xizang, Peoples R China.
EM gaohui9512@163.com; 229836739@qq.com; 373318447@qq.com;
   624608476@qq.com; yucuicui12345@163.com; pengyingfu@jsu.edu.cn
RI liu, xueping/MAH-6194-2025
FU National Natural Science Foundation of China [81760058, 81560059,
   81660042, 82160059]; Scientific Research Project of Health and Family
   Planning Commission of Hunan Province [C2017025]; Project of Medical and
   Health Science and Technology of Shaoxing City [2020A13063]; Startup
   Fund for Research of Shaoxing University [20205021]
FX AcknowledgmentsThis work was supported by the National Natural Science
   Foundation of China (Nos. 81760058, 81560059, 81660042, 82160059), the
   Scientific Research Project of Health and Family Planning Commission of
   Hunan Province (No. C2017025), the Project of Medical and Health Science
   and Technology of Shaoxing City (No. 2020A13063), and the Startup Fund
   for Research of Shaoxing University (No. 20205021).
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NR 40
TC 6
Z9 8
U1 0
U2 27
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 30
PY 2021
VL 2021
AR 1060271
DI 10.1155/2021/1060271
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ZR0ZQ
UT WOS:000767522700002
PM 34887995
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Guan, S
   He, JK
   Guo, WX
   Wei, JY
   Lu, J
   Deng, XM
AF Guan, Shuang
   He, Jiakang
   Guo, Weixiao
   Wei, Jingyuan
   Lu, Jing
   Deng, Xuming
TI Adjuvant effects of salidroside from Rhodiola rosea L. on the
   immune responses to ovalbumin in mice
SO IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
LA English
DT Article
DE Salidroside; adjuvant; cytokines; antibody
ID FUNCTION IN-VITRO; MURINE SPLENOCYTE; EXTRACT; SAPONINS; STRESS; SYSTEM;
   RAT
AB Salidroside, a major component of Rhodiola rosea L., was evaluated for its adjuvant effects on the immune responses in mice by ovalbumin (OVA) stimulation. BALB/c mice were immunized subcutaneously with OVA 100 mu g or OVA 100 mu g dissolved in saline containing alum (100 mu g) or salidroside (12.5, 25, or 50 mu g) on Days 1 and 15. Two weeks later (Day 28), blood samples were collected to analyze OVA-specific IgG, IgG1, and IgG2b antibodies. Meanwhile, splenocytes were harvested to assess lymphocyte proliferation, cytokines (IL-2, IL-4, and IFN-gamma) production, and CD4(+), CD8(+) lymphocyte subsets. The results indicated that co-administration of salidroside with OVA significantly enhanced the ConA-, LPS-, and OVA-induced splenocyte proliferation, produced more IL-2, IL-4, IFN-gamma, and IgG, IgG1, and IgG2b antibody levels, and increased the percentage of CD4(+), CD8(+) lymphocyte subsets than OVA alone. Thus, salidroside possess immunological adjuvant activity by regulating humoral and cellular immune responses in mice.
C1 [Guan, Shuang; Guo, Weixiao; Wei, Jingyuan; Lu, Jing; Deng, Xuming] Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China.
   [Lu, Jing] Jilin Univ, Lab Nutr & Funct Food, Changchun 130062, Jilin, Peoples R China.
   [He, Jiakang] Guangxi Univ, Coll Anim Sci & Technol, Guangxi, Peoples R China.
C3 Jilin University; Jilin University; Guangxi University
RP Guan, S (corresponding author), Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China.
EM gshuang1973@126.com
RI Guan, Shuang/JXN-9245-2024
FU National Nature Science Foundation of China [30972212]
FX This study was financed by the National Nature Science Foundation of
   China (No. 30972212).
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NR 28
TC 29
Z9 37
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0892-3973
EI 1532-2513
J9 IMMUNOPHARM IMMUNOT
JI Immunopharmacol. Immunotoxicol.
PD DEC
PY 2011
VL 33
IS 4
BP 738
EP 743
DI 10.3109/08923973.2011.567988
PG 6
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA 843AC
UT WOS:000296643200023
PM 21711135
DA 2026-05-27
ER

PT J
AU Xian, H
   Zhao, J
   Zheng, Y
   Wang, MH
   Huang, J
   Wu, BX
   Sun, C
   Yang, YM
AF Xian, Hua
   Zhao, Jing
   Zheng, Yuan
   Wang, Meihong
   Huang, Jun
   Wu, Bingxin
   Sun, Cheng
   Yang, Yumin
TI MADP, a salidroside analog, protects hippocampal neurons from glutamate
   induced apoptosis
SO LIFE SCIENCES
LA English
DT Article
DE Salidroside analog; Hippocampal neurons; Apoptosis; Glutamate
   excitotoxicity; Neurodegeneration
ID CELL-DEATH; ACTIVATION; GLUCOSE; INJURY; ERK; MITOCHONDRIA; KINASES;
   PATHWAY; STRESS; EXERTS
AB Aims: To investigate the anti-apoptotic effect of MADP, an analog of salidroside, against glutamate induced apoptosis in the cultured rat hippocampal neurons.
   Main methods: Cytotoxicity was determined by the MTT method and lactate dehydrogenase release to the medium. Cell apoptosis was evaluated by Hoechst 33342 staining, TUNEL assay and flow cytometric analysis. Western blotting was applied for detecting protein levels of cellular signaling molecules.
   Key findings: Our results showed that glutamate exposure significantly induces cell apoptosis, whereas the pretreatment of salidroside or MADP remarkably improves cell viability. Most importantly, the anti-apoptotic effect of MADP against glutamate insult is superior to salidroside. To explore the involved mechanisms, we measured some pro-apoptotic and anti-apoptotic protein levels, and several cell survival signaling pathways were analyzed as well. No visible alterations in Bcl-2 and Bax protein levels were observed by MADP or salidroside. Ala and JNK phosphorylation was robustly stimulated by MADP in the glutamate-treated neurons. Salidroside treatment results in a slight activation in Akt, while no significant alteration in JNK activity was observed.
   Significance: MADP exhibits higher capacity to attenuate glutamate induced cell apoptosis in the cultured rat hippocampal neurons, suggesting that MADP might be a better candidate than salidroside for developing novel drugs treating neuron loss associated disorders. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Xian, Hua] Nantong Univ, Affiliated Hosp, Dept Pediat Surg, Nantong 226001, Jiangsu, Peoples R China.
   [Zhao, Jing; Zheng, Yuan; Wang, Meihong; Sun, Cheng; Yang, Yumin] Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
   [Huang, Jun; Wu, Bingxin] Nantong Univ, Sch Med, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Sun, C (corresponding author), Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM suncheng1975@ntu.edu.cn; yangym@ntu.edu.cn
RI Sun, Cheng/M-8729-2017; Zheng, Yuanyuan/HJA-4183-2022
FU National Natural Science Foundation of China [81371687, 21242005,
   81171457, 31271260]; Natural Science Foundation of Jiangsu Province
   [BK2011132]; Priority Academic Program Development (PAPD) of Jiangsu
   Higher Education Institutions
FX This work was supported by Grants from the National Natural Science
   Foundation of China (Nos. 81371687; 21242005; 81171457; 31271260), the
   Natural Science Foundation of Jiangsu Province (BK2011132) and the
   Priority Academic Program Development (PAPD) of Jiangsu Higher Education
   Institutions.
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U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAY 8
PY 2014
VL 103
IS 1
BP 34
EP 40
DI 10.1016/j.lfs.2014.02.040
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA AG4CD
UT WOS:000335365900005
PM 24631136
DA 2026-05-27
ER

PT J
AU Hao, XZ
   Yuan, J
   Dong, HX
AF Hao, Xiuzhen
   Yuan, Jie
   Dong, Huixiao
TI Salidroside prevents diabetes-induced cognitive impairment via
   regulating the Rho pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; diabetes; cognitive impairment; Rho; nuclear factor-B
ID CARDIOMETABOLIC RISK; GLYCEMIC CONTROL; DEFICITS; INTERVENTION;
   INFLAMMATION; DYSFUNCTION; ACTIVATION; EXERCISE; STRESS; ADULTS
AB In previous years, it has been found that Rhodiola has a wide range of pharmacological effects in diseases of the cardiovascular system, as it can remove superoxide anions and hydroxyl radicals in chemical reactions. Behavioral assessment was used to measure cognitive impairment. Inflammation, oxidative stress and caspase-3 activity were measured using commercial kits. Western blot analysis was used to measure Rho/Rho-associated kinase (ROCK)/sirtuin 1 (SIRT1)/nuclear factor (NF)-B protein expression. The objective of the present study was to investigate the protective effect of salidroside on diabetes and diabetes-induced cognitive impairment. The results of the study demonstrated that salidroside prevented cognitive impairment, decreased serum blood glucose levels and increased body weight, reduced fasting blood glucose levels and blood lipid levels, and inhibited oxidative stress, inflammation and nerve cell apoptosis in the diabetic rat model. Salidroside suppressed ROCK/ SIRT1 NF-B pathway and protein expression in the diabetic rats. These data showed that salidroside prevented diabetes-induced cognitive impairment by regulating the Rho/ROCK/SIRT1/NF-B pathway.
C1 [Hao, Xiuzhen; Dong, Huixiao] Jining 1 Peoples Hosp, Dept Neurosurg, 6 Jiankang Rd, Jining 272000, Shandong, Peoples R China.
   [Yuan, Jie] North China Univ Sci & Technol, Inst Mental Hlth, Tangshan 063009, Hebei, Peoples R China.
C3 North China University of Science & Technology
RP Dong, HX (corresponding author), Jining 1 Peoples Hosp, Dept Neurosurg, 6 Jiankang Rd, Jining 272000, Shandong, Peoples R China.
EM dovlbm13964@126.com
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NR 31
TC 20
Z9 20
U1 0
U2 27
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2019
VL 19
IS 1
BP 678
EP 684
DI 10.3892/mmr.2018.9621
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HF7PE
UT WOS:000454431000074
PM 30387819
OA Bronze
DA 2026-05-27
ER

PT J
AU Han, JX
   Luo, LL
   Wang, YC
   Wu, SR
   Kasim, V
AF Han, Jingxuan
   Luo, Lailiu
   Wang, Yicheng
   Wu, Shourong
   Kasim, Vivi
TI Therapeutic potential and molecular mechanisms of salidroside in
   ischemic diseases
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE Rhodiola; salidroside; ischemic diseases; hypoxia; angiogenesis
ID CRITICAL LIMB ISCHEMIA; PERIPHERAL ARTERY-DISEASE; INTER-SOCIETY
   CONSENSUS; REPERFUSION INJURY; RHODIOLA-ROSEA; MYOCARDIAL-ISCHEMIA;
   HEPATIC ISCHEMIA; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; CELL
   THERAPY
AB Rhodiola is an ancient wild plant that grows in rock areas in high-altitude mountains with a widespread habitat in Asia, Europe, and America. From empirical belief to research studies, Rhodiola has undergone a long history of discovery, and has been used as traditional medicine in many countries and regions for treating high-altitude sickness, anoxia, resisting stress or fatigue, and for promoting longevity. Salidroside, a phenylpropanoid glycoside, is the main active component found in all species of Rhodiola. Salidroside could enhance cell survival and angiogenesis while suppressing oxidative stress and inflammation, and thereby has been considered a potential compound for treating ischemia and ischemic injury. In this article, we highlight the recent advances in salidroside in treating ischemic diseases, such as cerebral ischemia, ischemic heart disease, liver ischemia, ischemic acute kidney injury and lower limb ischemia. Furthermore, we also discuss the pharmacological functions and underlying molecular mechanisms. To our knowledge, this review is the first one that covers the protective effects of salidroside on different ischemia-related disease.
C1 [Han, Jingxuan; Luo, Lailiu; Wang, Yicheng; Wu, Shourong; Kasim, Vivi] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing, Peoples R China.
   [Han, Jingxuan; Luo, Lailiu; Wang, Yicheng; Wu, Shourong; Kasim, Vivi] State & Local Joint Engn Lab Vasc Implants, Chongqing, Peoples R China.
   [Wu, Shourong; Kasim, Vivi] Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing, Peoples R China.
C3 Chongqing University; Chongqing University
RP Wu, SR; Kasim, V (corresponding author), Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing, Peoples R China.; Wu, SR; Kasim, V (corresponding author), State & Local Joint Engn Lab Vasc Implants, Chongqing, Peoples R China.; Wu, SR; Kasim, V (corresponding author), Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing, Peoples R China.
EM shourongwu@cqu.edu.cn; vivikasim@cqu.edu.cn
RI Kasim, Vivi/AID-0964-2022
OI Kasim, Vivi/0000-0001-9182-8230
FU National Natural Science Foundation of China;  [31871367];  [81872273]
FX This work was supported by grants from the National Natural Science
   Foundation of China (31871367 and 81872273).
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NR 154
TC 36
Z9 44
U1 0
U2 58
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 19
PY 2022
VL 13
AR 974775
DI 10.3389/fphar.2022.974775
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4H3KF
UT WOS:000849779600001
PM 36060000
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, J
   Jin, RG
   Xiao, L
   Wang, QJ
   Yan, TH
AF Wang Jing
   Jin Rong-Guang
   Xiao Lu
   Wang Qiu-Juan
   Yan Tian-Hua
TI Anti-asthma effects of synthetic salidroside through regulation of
   Th1/Th2 balance
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Synthetic salidroside; Asthma; Th1/Th2
ID MURINE MODEL; RESPONSES; ASTHMA; OVALBUMIN; ALLERGY; CELLS
AB AIM: The aim of the study was to investigate the effect and mechanism of action of synthetic salidroside in an ovalbumin (OVA)-induced asthma model in mice.
   METHOD: BALB/c mice were sensitized with an intraperitoneal injection of ovalbumin (OVA) to induce a mouse model of asthma in paracmasis. The mice were treated with dexamethasone as the positive control. At the end of the study, respiratory reactivity was detected, the numbers of various kinds of white blood cells in the bronchoalveolar lavage fluid (BALF) were counted, and the levels of IL-4 and INF-gamma in BALF were determined. Quantitative PCR was used to detect the mRNA contents of IL-4 and INF-gamma in lung tissue. Histologic examination was performed to observe inflammatory cellular infiltration.
   RESULTS: Salidroside treatment virtually eliminated airway hyper-reactivity, markedly reduced the eosinophil percent, obviously reduced the levels of IL-4 and raised INF-gamma in the bronchoalveolar lavage fluid (BALF) compared with the sham-treated group. Quantitative PCR on the mRNA content of IL-4 and lNF-gamma provided confirmation. Lung histologic observations showed that salidroside reduced inflammation and edema. These effects were equivalent to the effects of dexamethasone.
   CONCLUSION: Synthetic salidroside exhibits an anti-asthma effect which is related to the regulation of Th1/Th2 balance. This provides a new possibility for treatment of allergic asthma.
C1 [Wang Jing; Jin Rong-Guang; Xiao Lu; Wang Qiu-Juan; Yan Tian-Hua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
EM tianhua_yan@yahoo.com.cn
RI Su, Tianyuan/Y-7054-2019
FU major drug discovery projects during the 12th five year plan
   [2011ZX09102-002-01]
FX This project was supported by major drug discovery projects during the
   12th five year plan (No. 2011ZX09102-002-01)
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NR 17
TC 35
Z9 41
U1 0
U2 21
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD JUL
PY 2014
VL 12
IS 7
BP 500
EP 504
DI 10.1016/S1875-5364(14)60078-9
PG 5
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA AN1NO
UT WOS:000340350800004
PM 25053548
DA 2026-05-27
ER

PT J
AU Zhu, MJ
   Yu, J
AF Zhu, Meijiang
   Yu, Jing
TI Salidroside alleviates ferroptosis in FAC-induced Age-related macular
   degeneration models by activating Nrf2/SLC7A11/GPX4 axis
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Retinal pigment epithelium cells; Ferroptosis; Age-related macular
   degeneration; Salidroside; Nrf2
ID OXIDATIVE STRESS; INHIBITION
AB Introduction: Age-related macular degeneration (AMD) is a significant contributor to irreversible impairment in visual capability, particularly in its non-neovascular (dry) form. Ferroptosis, an emerging form of programmed necrosis, involves generating lipid peroxidation (LOS) through free iron and reactive oxygen species (ROS). Salidroside, a glycoside from Rhodiola rosea, known for anti-inflammatory and antioxidant properties. The research aim was exploring whether ferroptosis exists in dry AMD pathogenesis and elucidate salidroside's protective mechanisms against ferroptosis in AMD murine models and ARPE-19 cells. Methods: ARPE-19 cells were treated with varying concentrations of ferrous ammonium citrate (FAC) and salidroside. In an in vivo model, C57BL/6 mice were administered intraperitoneal injections of salidroside for 7 consecutive days, followed by an intravitreal injection (IVT) of FAC. After 7 days, the eyeballs were harvested for subsequent analyses. Ferroptosis markers were assessed using western blotting, immunofluorescence staining, and flow cytometry. To further elucidate the modulatory role of Nrf2 in ferroptosis, ARPE-19 cells were transfected with si-Nrf2. Results: In vitro, FAC-treated ARPE-19 cells exhibited reduced viability, decreased mitochondrial membrane potential (MMP), and accumulation of iron and lipid peroxidation (LOS) products. In vivo, FAC administration by IVT led to outer nuclear layer thinning and compromised tight junctions in RPE cells. The GPX4, Nrf2, and SLC7A11 expressions were downregulated both in vitro and in vivo. Salidroside upregulated Nrf2 and ameliorated these outcomes, but its effects were attenuated in ARPE-19 cells transfected with si-Nrf2. Conclusion: Our study establishes that FAC induces RPE cell ferroptosis within dry AMD, and salidroside exerts therapeutic effects by triggering Nrf2/SLC7A11/GPX4 signaling axis.
C1 [Zhu, Meijiang; Yu, Jing] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Shanghai, Peoples R China.
C3 Tongji University
RP Yu, J (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Shanghai, Peoples R China.
EM 709094947@qq.com; dryujing@aliyun.com
OI Zhu, Meijiang/0000-0001-7493-017X
FX Funding The authors declare that no funds, grants, or other support were
   received during the preparation of this manuscript.
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NR 47
TC 13
Z9 14
U1 3
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 5
PY 2024
VL 142
AR 113041
DI 10.1016/j.intimp.2024.113041
EA SEP 2024
PN A
PG 10
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA G3G8Z
UT WOS:001315567500001
PM 39260309
DA 2026-05-27
ER

PT J
AU Wu, D
   Yuan, P
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   Fan, XM
   Duan, QH
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   Zhu, F
AF Wu, Dan
   Yuan, Ping
   Ke, Changshu
   Xiong, Hua
   Chen, Jingwen
   Guo, Jinguang
   Lu, Mingmin
   Ding, Yanyan
   Fan, Xiaoming
   Duan, Qiuhong
   Shi, Fei
   Zhu, Feng
TI Salidroside suppresses solar ultraviolet-induced skin inflammation by
   targeting cyclooxygenase-2
SO ONCOTARGET
LA English
DT Article
DE salidroside; cyclooxygenase-2; solar UV; skin inflammation; p38
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RADIATION; INJURY; CANCER; RISK;
   CARCINOGENESIS; METAANALYSIS; ANTIOXIDANT; ACTIVATION
AB Solar ultraviolet (SUV) irradiation causes skin disorders such as inflammation, photoaging, and carcinogenesis. Cyclooxygenase-2 (COX-2) plays a key role in SUV-induced skin inflammation, and targeting COX-2 may be a strategy to prevent skin disorders. In this study, we found that the expression of COX-2, phosphorylation of p38 or JNKs were increased in human solar dermatitis tissues and SUV-irradiated human skin keratinocyte HaCaT cells and mouse epidermal JB6 Cl41 cells. Knocking down COX-2 inhibited the production of prostaglandin E-2 (PGE(2)), the phosphorylation of p38 or JNKs in SUV-irradiated cells, which indicated that COX-2 is not only the key enzyme for PGs synthesis, but also an upstream regulator of p38 or JNKs after SUV irradiation. The virtual ligand screening assay was used to search for natural drugs in the Chinese Medicine Database, and indicated that salidroside might be a COX-2 inhibitor. Molecule modeling indicated that salidroside can directly bind with COX-2, which was proved by in vitro pull-down binding assay. Ex vivo studies showed that salidroside has no toxicity to cells, and inhibits the production of PGE(2), phosphorylation of p38 or JNKs, and secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) caused by SUV irradiation. In vivo studies demonstrated that salidroside attenuates the skin inflammation induced by SUV. In brief, our data provided the evidences for the protective role of salidroside against SUV-induced inflammation by targeting COX-2, and salidroside might be a promising drug for the treatment of SUV-induced skin inflammation.
C1 [Wu, Dan; Chen, Jingwen; Guo, Jinguang; Lu, Mingmin; Shi, Fei] Gen Hosp Air Force, Dept Dermatol, Beijing 100142, Peoples R China.
   [Wu, Dan; Yuan, Ping; Ding, Yanyan; Fan, Xiaoming; Duan, Qiuhong; Zhu, Feng] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Biochem & Mol Biol, Wuhan 430030, Hubei, Peoples R China.
   [Ke, Changshu; Xiong, Hua] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Pathol, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Shi, F (corresponding author), Gen Hosp Air Force, Dept Dermatol, Beijing 100142, Peoples R China.; Duan, QH; Zhu, F (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Biochem & Mol Biol, Wuhan 430030, Hubei, Peoples R China.
EM duanqhwz@hust.edu.cn; shf_1969@163.com; fengzhu@hust.edu.cn
RI Zhu, Feng/C-1303-2010; Yuan, Pingpeng/MTA-7541-2025
OI Zhu, Feng/0000-0003-1172-0102; 
FU National Natural Science Foundation of China [81472602, 81450110449,
   81250004]; Independent innovation project of Huazhong University of
   Science and Technology [2014TS063, 2015650011, 2014ZZGH013]; Natural
   Science Foundation of Hubei Province [2014CFB447]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81472602, 81450110449, 81250004), and the Independent
   innovation project of Huazhong University of Science and Technology (No.
   2014TS063, 2015650011 & 2014ZZGH013), and the Natural Science Foundation
   of Hubei Province (No. 2014CFB447).
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NR 36
TC 28
Z9 32
U1 0
U2 40
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD MAY 3
PY 2016
VL 7
IS 18
BP 25971
EP 25982
DI 10.18632/oncotarget.8300
PG 12
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA DO3ZW
UT WOS:000377722300082
PM 27028995
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, JQ
   Zhang, YG
   Yang, ZM
   Zhang, JX
   Lin, R
   Luo, DS
AF Li, Jiaqi
   Zhang, Yongguang
   Yang, Zhimin
   Zhang, Jingxian
   Lin, Ren
   Luo, Daoshu
TI Salidroside promotes sciatic nerve regeneration following combined
   application epimysium conduit and Schwann cells in rats
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Salidroside; RSC96 Schwann cells; autologous epimysium conduit;
   combination application; nerve regeneration; sciatic nerve injury
ID NEUROTROPHINS; INJURY; REPAIR
AB Schwann cell and nerve conduit are crucial for nerve regeneration and re-myelination after peripheral nerves injury. To investigate the effects of Salidroside on autogenous epimysium conduit mixed with BD matrigel and RSC96 Schwann cells on an animal model with 5 mm sciatic nerve defect injury in rat, motor function, muscle reinnervation, immunohistochemical staining, retrograded tracing and Western blot were used in this study. The results showed that Salidroside enhanced the compound effects of epimysium conduit mixed with BD matrigel and RSC96 Schwann cells to improve the sciatic functional index and the gastrocnemius muscle weight ratio, which were better than EPM group at 8 weeks and 12 weeks post operation. Immunofluorescence and Western blot results of P75(NTR) showed that Salidroside improved the sciatic nerve regeneration, and retrograded tracing of CTB-Alexa 488 also supported that Salidroside was better to promote CTB tracer transporting from the distal nerve defect to the ipsilateral dorsal root ganglion and ventral horn of L3-L5 spinal cord on post-operation 8 weeks and 12 weeks. Our results demonstrated that Salidroside improved the effect of autogenous epimysium conduit mixed with BD matrigel and RSC96 Schwann cells on sciatic nerve regeneration in our study.
   Impact statement
   Peripheral nerve injury and regeneration remain a major challenge. Although nerve conduit and Schwann cells have been used to study the nerve regeneration, our results demonstrated that Salidroside improved the regenerative effect in a rat model with sciatic nerve injury model, following a combined application of autogenous epimysium conduit mixed with Schwann cells. Different concentrations of Salidroside combining autogenous epimysium conduit and Schwann cells were applied to compare the epimysium conduit group and the epimysium conduit combining Schwann cells group. Based on the results of motor function and muscle reinnervation evaluation, as well as neuronal tracing and expression of P75(NTR), our study for the first time suggests that Salidroside may improve the regeneration effect on the sciatic nerve following a combined application of epimysium conduit and RSC96 Schwann cells in rats.
C1 [Li, Jiaqi; Yang, Zhimin; Zhang, Jingxian; Lin, Ren; Luo, Daoshu] Fujian Med Univ, Sch Basic Med Sci, Dept Human Anat Histol & Embryol, Fuzhou 350122, Peoples R China.
   [Zhang, Yongguang] Xiamen Univ, Dongfang Hosp, Hosp 900, Dept Orthopaed,Joint Logist Support Force, Fuzhou 350025, Peoples R China.
   [Zhang, Yongguang] Fujian Med Univ, Fuzong Clin Med Coll, Fuzhou 350025, Peoples R China.
   [Lin, Ren; Luo, Daoshu] Key Lab Brain Aging & Neurodegenerat Dis Fujian P, Fuzhou 350122, Peoples R China.
C3 Fujian Medical University; Xiamen University; Fujian Medical University
RP Luo, DS (corresponding author), Key Lab Brain Aging & Neurodegenerat Dis Fujian P, Fuzhou 350122, Peoples R China.
EM luods2004@fjmu.edu.cn
OI Luo, Daoshu/0000-0001-9013-1052; jiaqi, Li/0009-0005-4613-5116; zm,
   yang/0000-0002-7527-2313
FU National Natural Science Foundation of China [81671100, 81501896];
   Natural Science Foundation of Fujian province of China [2015J05166]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was funded by National Natural Science Foundation of China (81671100;
   81501896) and Natural Science Foundation of Fujian province of China
   (2015J05166).
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NR 26
TC 12
Z9 14
U1 0
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD MAR
PY 2020
VL 245
IS 6
BP 522
EP 531
AR 1535370220906541
DI 10.1177/1535370220906541
EA FEB 2020
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LA4MF
UT WOS:000513397500001
PM 32053008
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Stepanova, A
   Malunova, M
   Salamaikina, S
   Selimov, R
   Solov'eva, A
AF Stepanova, Anna
   Malunova, Maria
   Salamaikina, Svetlana
   Selimov, Renat
   Solov'eva, Aleksandra
TI Establishment of Rhodiola quadrifida Hairy Roots and Callus
   Culture to Produce Bioactive Compounds
SO PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
LA English
DT Article
DE Rhodiola quadrifida; hairy roots; callus culture; HPLC; salidroside;
   rosavin
ID RHIZOGENES-MEDIATED TRANSFORMATION; UNDERGROUND PART; TISSUE-CULTURES;
   PALL FISCH; ROSEA; SALIDROSIDE; DIOSGENIN; EXTRACTS; BIOSYNTHESIS;
   TYROSOL
AB Rhodiola quadrifida is a rare mountain medicinal plant whose root extracts are used in traditional Chinese medicine as a hemostatic, antitussive, and tonic in the treatment of gynecological diseases. The aim of the study was to obtain R. quadrifida cultures at different degrees of differentiation in vitro and compare their growth characteristics and the content of salidroside and rosavin. Hairy roots were obtained by incubating cotyledons and hypocotyls in a suspension of Agrobacterium rhizogenes strain A4. The presence of the rolB and rolC genes was proven by polymerase chain reaction. The obtained roots were cultivated in Murashige-Skoog medium (MS). Calluses were obtained from the hairy roots in MS medium with the addition of hormones: 3 mg/L 2,4 D and 0.5 mg/L BAP. The presence of the main secondary metabolites of R. quadrifida, salidroside and rosavin, in calluses and salidroside in hairy roots by HPLC/MS was confirmed. The content of salidroside in callus culture was significantly higher than in hairy roots, 0.158 and 0.047%, respectively. The content of rosavin in callus culture was 0.07%. The content of rosavin and salidroside in callus culture was close to the level of these substances in the rhizomes of R. quadrifida plants growing in vivo, making this culture promising for its possible biotechnological use.
C1 [Stepanova, Anna; Malunova, Maria; Salamaikina, Svetlana; Solov'eva, Aleksandra] KA Timiryazev Inst Plant Physiol RAS, Grp Specialized Root Metab, Moscow 127276, Russia.
   [Selimov, Renat] OOO NVC Agrovetzaschita, Bioanalyt Lab, Moscow 129329, Russia.
C3 Russian Academy of Sciences; Timiryazev Institute of Plant Physiology
RP Stepanova, A (corresponding author), KA Timiryazev Inst Plant Physiol RAS, Grp Specialized Root Metab, Moscow 127276, Russia.
EM step_ann@mail.ru
RI Salamaikina, Svetlana/JCE-2228-2023; /AAO-6106-2021; Malunova,
   Mariya/PGM-1407-2026; Stepanova, Anna/B-3679-2014
OI Salamaikina, Svetlana/0000-0002-2517-5048; Малунова,
   Мария/0009-0003-3556-9475; Stepanova, Anna/0000-0002-0745-2611
FU Ministry of Education and Science of the Russian Federation
FX This work was supported by the Ministry of Education and Science of the
   Russian Federation (Topic No.AAAA-A19-119041890054-8).
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NR 34
TC 12
Z9 12
U1 4
U2 32
PU TECH SCIENCE PRESS
PI HENDERSON
PA 871 CORONADO CENTER DR, SUTE 200, HENDERSON, NV 89052 USA
SN 0031-9457
EI 1851-5657
J9 PHYTON-INT J EXP BOT
JI Phyton-Int. J. Exp. Bot.
PY 2021
VL 90
IS 2
BP 543
EP 552
DI 10.32604/phyton.2021.013223
PG 10
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA QE5NE
UT WOS:000616252800016
OA gold
DA 2026-05-27
ER

PT J
AU Li, X
   Erden, O
   Li, L
   Ye, QD
   Wilson, A
   Du, W
AF Li, Xue
   Erden, Ozlem
   Li, Liang
   Ye, Qidong
   Wilson, Andrew
   Du, Wei
TI Binding to WGR Domain by Salidroside Activates PARP1 and Protects
   Hematopoietic Stem Cells from Oxidative Stress
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID DNA-DAMAGE REPAIR; FANCONI-ANEMIA; SELF-RENEWAL; RHODIOLA-ROSEA;
   DOUBLE-BLIND; MICE; POLY(ADP-RIBOSYL)ATION; IDENTIFICATION;
   DEFICIENCIES; EXPRESSION
AB Aims: A component of the base excision repair pathway, poly(ADP-ribose) polymerase-1 (PARP1) functions in multiple cellular processes, including DNA repair and programmed cell death. We previously showed that Salidroside, a phenylpropanoid glycoside isolated from medicinal plants, prevented the loss of hematopoietic stem cells (HSCs) in native mice and rescued HSCs repopulating in transplanted recipients under oxidative stress. The aim of this study was to investigate the mechanism by which PARP1 activation by Salidroside maintains HSCs under oxidative stress. Results: We found that although there were no spontaneous defects in hematopoiesis in Parp1(-/-) mice, oxidative stress compromised the repopulating capacity of Parp1(-/-) HSCs in transplanted recipient mice. A biochemical study using truncated proteins lacking the defined functional domains of PARP1 showed that the tryptophan-glycine-arginine-rich (WGR) domain of PARP1 was critical for Salidroside binding and subsequent PARP1 activation under oxidative stress. Functionally, complementation of Parp1(-/-) HSCs with full-length PARP1(WT), but not the PARP1(R591K) mutant in WGR domain restored Salidroside-stimulated PARP1 activation in vitro. Mechanistically, activated PARP1 by Salidroside enhanced the repopulating capacity of the stressed HSCs by accelerating oxidative DNA damage repair. Innovations and Conclusion: Our findings reveal the action of mechanism for Salidroside in PARP1 stimulation and a novel role of PARP1 activation in maintaining HSC function under oxidative stress. Antioxid. Redox Signal. 20, 1853-1865.
C1 [Li, Xue; Erden, Ozlem; Li, Liang; Wilson, Andrew; Du, Wei] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA.
   [Li, Xue] S China Normal Univ, Coll Pharmacol, Guangzhou, Guangdong, Peoples R China.
   [Ye, Qidong] Shanghai Childrens Med Ctr, Dept Hematol Oncol, Shanghai, Peoples R China.
C3 Cincinnati Children's Hospital Medical Center; South China Normal
   University; Shanghai Jiao Tong University
RP Du, W (corresponding author), Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA.
EM wei.du@cchmc.org
RI Du, Wei/ABD-4748-2020
OI Du, Wei/0000-0003-3669-537X
FU National Natural Science Foundation of China [81370608]; Guangdong
   Natural Science Foundation [S2013010013350]; Visiting Scholarships from
   South China Normal University; Shanghai Children's Medical center; NIH
FX We thank Dr. Madeleine Carreau (Laval University) for the
   Fanca+/- mice, Dr. Manuel Buchwald (Hospital for Sick
   Children, University of Toronto) for the Fancc-/- mice, Dr.
   Punam Malik (Cincinnati Children's Hospital Medical Center) for the
   lentiviral vector, Dr. Satoh Masahiko (Laval University Medical Center)
   for the pET32a-PARP1 plasmid, the Vector Core of the Cincinnati
   Children's Research Foundation (Cincinnati Children's Hospital Medical
   Center) for the preparation of lentivirus, and the Comprehensive Mouse
   and Cancer Core of the Cincinnati Children's Research Foundation
   (Cincinnati Children's Hospital Medical Center) for bone marrow
   transplantation service. This work was supported by the National Natural
   Science Foundation of China (81370608), the Guangdong Natural Science
   Foundation (S2013010013350), the Visiting Scholarships from South China
   Normal University, and the Shanghai Children's Medical center. WD is
   supported by a NIH T32 grant.
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NR 49
TC 26
Z9 34
U1 0
U2 22
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR 20
PY 2014
VL 20
IS 12
BP 1853
EP 1865
DI 10.1089/ars.2013.5600
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AD6ZQ
UT WOS:000333410600001
PM 24294904
OA hybrid
DA 2026-05-27
ER

PT J
AU Zhao, YH
   Ling, Y
   Zhao, J
   Yuan, Y
   Guo, YB
   Liu, Q
   Wu, BX
   Ding, ZY
   Yang, YM
AF Zhao, Yahong
   Ling, Yong
   Zhao, Jing
   Yuan, Ying
   Guo, Yibin
   Liu, Qiong
   Wu, Bingxin
   Ding, Zuoyou
   Yang, Yumin
TI Synthesis and Protective Effects of Novel Salidroside Analogues on
   Glucose and Serum Depletion Induced Apoptosis in PC12 Cells
SO ARCHIV DER PHARMAZIE
LA English
DT Article
DE Apoptosis; Cerebral ischemia; Glucose and serum depletion;
   Neuroprotective effect; PC12 cells; Salidroside analogues
ID IN-VITRO; DAMAGE; ISCHEMIA; BCL-2
AB Salidroside is a natural product isolated from Rhodiola rosea L. which possesses a wide range of biological activities, especially neuroprotective effects in the treatment of ischemic stroke. In an attempt to improve its neuroprotective effects, a series of novel salidroside analogues were synthesized and their neuroprotective activities were evaluated against the glucose and serum depletion-induced cell death in differentiated PC12 cells. Most target compounds displayed protective effects on the cell viability, especially for compound 6, which had a great potency superior to salidroside. MTT assay and Hoechst 33342 staining collectively showed that pretreatment with 6 attenuated cell viability loss and reduced apoptotic death in cultured PC12 cells with glucose and serum depletion. And its neuroprotective effects might be associated with the increase of the apoptosis-related protein Bcl-2/Bax expression ratio, and also with the inhibition of caspase-3 activation. Therefore, our new findings may provide potentially important information for further development of salidroside analogues and lay the basis for further studies on the cerebral ischemic stroke and neurodegenerative diseases for human clinical treatment.
C1 [Zhao, Yahong; Zhao, Jing; Yuan, Ying; Guo, Yibin; Liu, Qiong; Yang, Yumin] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China.
   [Ling, Yong] Nantong Univ, Dept Pharm, Sch Med, Nantong 226001, Peoples R China.
   [Wu, Bingxin; Ding, Zuoyou] Nantong Univ, Sch Med, Nantong 226001, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China.
EM yangym@ntu.edu.cn
RI Zhao, Yahong/JFA-2536-2023
FU Natural Science Foundation of China [21242005, 30970996, 81171457];
   Biotechnology and New Medicine Projects of Nantong City [AS2011016];
   Nature Science Foundation of Nantong University [10Z074, 12ZY035];
   Priority Academic Programs Development of Jiangsu Higher Education
   Institutions (PAPD)
FX We gratefully acknowledge the financial support by the Natural Science
   Foundation of China (grant nos. 21242005, 30970996, and 81171457),
   Biotechnology and New Medicine Projects of Nantong City (AS2011016),
   Nature Science Foundation of Nantong University (grant nos. 10Z074 and
   12ZY035), and also thank a project funded by the Priority Academic
   Programs Development of Jiangsu Higher Education Institutions (PAPD).
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NR 21
TC 12
Z9 12
U1 0
U2 38
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0365-6233
EI 1521-4184
J9 ARCH PHARM
JI Arch. Pharm.
PD APR
PY 2013
VL 346
IS 4
BP 300
EP 307
DI 10.1002/ardp.201200444
PG 8
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 123AP
UT WOS:000317360700005
PM 23440725
DA 2026-05-27
ER

PT J
AU Li, DP
   Fu, YH
   Zhang, W
   Su, GL
   Liu, B
   Guo, MY
   Li, FY
   Liang, DJ
   Liu, ZC
   Zhang, XC
   Cao, YG
   Zhang, NS
   Yang, ZT
AF Li, Depeng
   Fu, Yunhe
   Zhang, Wen
   Su, Gaoli
   Liu, Bo
   Guo, Mengyao
   Li, Fengyang
   Liang, Dejie
   Liu, Zhicheng
   Zhang, Xichen
   Cao, Yongguo
   Zhang, Naisheng
   Yang, Zhengtao
TI Salidroside attenuates inflammatory responses by suppressing nuclear
   factor-κB and mitogen activated protein kinases activation in
   lipopolysaccharide-induced mastitis in mice
SO INFLAMMATION RESEARCH
LA English
DT Article
DE Salidroside; Lipopolysaccharide (LPS); Mastitis; Cytokine; Nuclear
   factor-kappaB (NF-kappa B); Mitogen activated protein kinases (MAPKs)
ID ESCHERICHIA-COLI MASTITIS; TUMOR-NECROSIS-FACTOR; BACTERIAL
   LIPOPOLYSACCHARIDE; INTERLEUKIN-6 PRODUCTION; ENDOTHELIAL-CELLS; LPS
   PRETREATMENT; EPITHELIAL-CELLS; BOVINE MASTITIS; MAMMARY-GLAND; MURINE
   MODEL
AB Mastitis is defined as inflammation of the mammary gland in domestic dairy animals and humans. Salidroside, a major component isolated from Rhodiola rosea L., has potent anti-inflammatory properties, but whether it can be used in mastitis treatment has not yet been investigated. The aim of this study was to assess the protective effects of salidroside against lipopolysaccharide (LPS)-induced mastitis in mice and the mechanism of action.
   We used a mouse mastitis model in which mammary gland inflammation was induced by LPS challenge. Salidroside administered 1 h before LPS infusion significantly attenuated inflammatory cell infiltration, reduced the activity of myeloperoxidase in mammary tissue, and decreased the concentration of tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 in a dose-dependent manner. Further studies revealed that salidroside down-regulated phosphorylation of LPS-induced nuclear transcription factor-kappaB (NF-kappa B) p65 and inhibitor of NF-kappa B alpha (I kappa B alpha) in the NF-kappa B signal pathway, and suppressed phosphorylation of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK) in MAPKs signal pathways.
   This study demonstrates that salidroside is an effective suppressor of inflammation and may be a candidate for the prophylaxis of mastitis.
C1 [Li, Depeng; Fu, Yunhe; Zhang, Wen; Su, Gaoli; Liu, Bo; Guo, Mengyao; Li, Fengyang; Liang, Dejie; Liu, Zhicheng; Zhang, Xichen; Cao, Yongguo; Zhang, Naisheng; Yang, Zhengtao] Jilin Univ, Coll Anim Sci & Vet Med, Dept Clin Vet Med, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University
RP Yang, ZT (corresponding author), Jilin Univ, Coll Anim Sci & Vet Med, Dept Clin Vet Med, Changchun 130062, Jilin, Peoples R China.
EM yzt@jluhp.edu.cn
RI Guo, meng-yao/JOZ-4503-2023
OI Guo, meng-yao/0000-0002-7596-3632; Liu, Bo/0000-0002-1961-960X
FU National Natural Science Foundation of China [30972225, 30771596];
   Research Fund for the Doctoral Program of Higher Education of China
   [20110061130010]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 30972225, 30771596) and the Research Fund for
   the Doctoral Program of Higher Education of China (No. 20110061130010).
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NR 33
TC 110
Z9 134
U1 0
U2 50
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1023-3830
J9 INFLAMM RES
JI Inflamm. Res.
PD JAN
PY 2013
VL 62
IS 1
BP 9
EP 15
DI 10.1007/s00011-012-0545-4
PG 7
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 063NC
UT WOS:000313005500003
PM 22915087
DA 2026-05-27
ER

PT J
AU Liu, Q
   Chen, JZ
   Zeng, AQ
   Song, LJ
AF Liu, Qiong
   Chen, Jianzhu
   Zeng, Anqi
   Song, Linjiang
TI Pharmacological functions of salidroside in renal diseases: facts and
   perspectives
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE salidroside; diabetic nephropathy; renal interstitial fibrosis; acute
   kidney injury; inflammation; renal cell carcinoma
ID ISCHEMIA-REPERFUSION INJURY; RENIN-ANGIOTENSIN SYSTEM; INDUCED OXIDATIVE
   STRESS; ACUTE KIDNEY INJURY; RHODIOLA-ROSEA-L.; NF-KAPPA-B;
   DIABETIC-NEPHROPATHY; SIGNALING PATHWAYS; PODOCYTE INJURY; HIGH GLUCOSE
AB Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, and altitude sickness prevention properties. Salidroside, a most active constituent derived from Rhodiola rosea, exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, and anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role of salidroside has burgeoned over the last decade, making it a beneficial option for the prevention and treatment of multiple diseases, including atherosclerosis, Alzheimer's disease, Parkinson's disease, cardiovascular disease, and more. With its anti-aging and renoprotective effects, in parallel with the inhibition of oxidative stress and inflammation, salidroside holds promise as a potential therapeutic agent for kidney damage. This article provides an overview of the microinflammatory state in kidney disease and discuss the current therapeutic strategies, with a particular focus on highlighting the recent advancements in utilizing salidroside for renal disease. The potential mechanisms of action of salidroside are primarily associated with the regulation of gene and protein expression in glomerular endothelial cells, podocytes, renal tubule cells, renal mesangial cells and renal cell carcinoma cell, including TNF-alpha, TGF-beta, IL-1 beta, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1 alpha, BIM, as well as the modulation of AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1 alpha, ROS/Src/Cav-1, Akt/GSK-3 beta, TXNIP-NLRP3, ERK1/2, TGF-beta 1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a beta-catenin, TLR4/NF-kappa B, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To the best of our knowledge, this review is the first to comprehensively cover the protective effects of salidroside on diverse renal diseases, and suggests that salidroside has great potential to be developed as a drug for the prevention and treatment of metabolic syndrome, cardiovascular and cerebrovascular diseases and renal complications.
C1 [Liu, Qiong; Chen, Jianzhu; Song, Linjiang] Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Sichuan, Peoples R China.
   [Zeng, Anqi] Sichuan Acad Chinese Med Sci, Sichuan Inst Translat Chinese Med, Translat Chinese Med Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Song, LJ (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Sichuan, Peoples R China.; Zeng, AQ (corresponding author), Sichuan Acad Chinese Med Sci, Sichuan Inst Translat Chinese Med, Translat Chinese Med Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China.
EM zeng6002aq@163.com; songlinjiang@cdutcm.edu.cn
OI Liu, Qiong/0009-0007-2664-3919
FU Xinglin project of Chengdu University of Traditional Chinese Medicine
   [ZKYY 2019, MPRC2021012]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The work is supported by
   Xinglin project of Chengdu University of Traditional Chinese Medicine
   (ZKYY 2019, MPRC2021012).
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NR 188
TC 35
Z9 40
U1 4
U2 51
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 8
PY 2024
VL 14
AR 1309598
DI 10.3389/fphar.2023.1309598
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GL2C0
UT WOS:001152748200001
PM 38259279
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, HJ
   Wang, XZ
   Feng, YP
   Zhang, KW
   Peng, MDZ
   Wu, XW
   Li, Y
AF Wang, Hongjin
   Wang, Xianzhen
   Feng, Yanping
   Zhang, Kewei
   Peng, Maodongzhi
   Wu, Xiaowei
   Li, Yi
TI Salidroside Reduced Ca2+-CaM-CAMKII-Dependent eNOS/NO
   Activation to Decrease Endothelial Cell Injury Induced by Cold Combined
   with Hypoxia
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Salidroside; Aglycones; Endothelial cell; Hypoxia/hypothermia; eNOS/NO
ID ALTITUDE PULMONARY-EDEMA; CARDIOVASCULAR HEALTH; MORTALITY; DISEASE;
   IMPACT
AB To investigate vascular endothelium damage in rats exposed to hypoxic and cold and the effect of salidroside in protecting against this damage. A rat isolated aortic ring hypoxia/cold model was established to simulate exposure to hypoxic and cold. The levels of endothelial cell injury markers were measured by ELISA. TEM was performed to observe the ultrastructure of vascular ring endothelial cells. In vitro assays were performed to verify the effect of salidroside on endothelial cells. CCK-8 and flow cytometry were performed to analyze endothelial cell survival and apoptosis, respectively. Ca2+ concentrations were measured by Flow cytometry, and the expressions of NOS/NO pathway-related proteins were measured by WB. Endothelial cell damage, mitochondrial swelling, autophagy, and apoptosis were increased in the hypoxia group and hypoxia/hypothermia group. All of these effects were inhibited by salidroside. Moreover, exposure to cold combined with hypoxia reduced the NO levels, Ca2+ concentrations and NOS/NO pathway-related protein expression in the hypoxia group and hypoxia/hypothermia group. Salidroside treatment reversed these changes. Salidroside protected against endothelial cell injury induced by cold and hypoxia through reduction of Ca2+-CaM-CAMKII-dependent eNOS/NO activation, thereby preventing mitochondrial damage, reducing ROS levels, and inhibiting apoptosis.
C1 [Wang, Hongjin; Wang, Xianzhen; Feng, Yanping; Zhang, Kewei; Peng, Maodongzhi; Wu, Xiaowei; Li, Yi] Qinghai Univ, Dept Burn & Plast Surg, Affiliated Hosp, Xining 810001, Peoples R China.
C3 Qinghai University
RP Li, Y (corresponding author), Qinghai Univ, Dept Burn & Plast Surg, Affiliated Hosp, Xining 810001, Peoples R China.
EM 19685400@qq.com
FU The Chinese Academy of Sciences Western Young Scholars Program; Young
   and Middle-aged Research Foundation of Affiliated Hospital of Qinghai
   University [ASRF-2017-YB-06]; Qinghai Provincial Central Guidance Fund
   for Local Science and Technology Development [2023ZY0212]; Young and
   middle-aged lifting project of Qinghai Science and Technology
   Association [2019QHSKXRCTJ03]; Qinghai Province "Kunlun Talents High-end
   Innovation and Entrepreneurial Talents" project
FX This project was supported by The Chinese Academy of Sciences Western
   Young Scholars Program; Young and Middle-aged Research Foundation of
   Affiliated Hospital of Qinghai University (No. ASRF-2017-YB-06); Qinghai
   Provincial Central Guidance Fund for Local Science and Technology
   Development (No. 2023ZY0212); Young and middle-aged lifting project of
   Qinghai Science and Technology Association (No. 2019QHSKXRCTJ03), and
   Qinghai Province "Kunlun Talents High-end Innovation and Entrepreneurial
   Talents" project.
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NR 49
TC 5
Z9 6
U1 1
U2 14
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD DEC
PY 2024
VL 82
IS 4
BP 3477
EP 3487
DI 10.1007/s12013-024-01434-2
EA JUL 2024
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA M7D7W
UT WOS:001271778400005
PM 39020087
DA 2026-05-27
ER

PT J
AU Li, ZP
   Sun, A
   Wang, X
   Abulimiti, M
   Li, ZT
   Li, ZJ
AF Li, Zipeng
   Sun, Ao
   Wang, Xin
   Abulimiti, Munila
   Li, Zhongtang
   Li, Zhongjun
TI Synthesis and bioactivity evaluation of mirror isomer salidroside
   derivatives as potent antioxidant and anti-inflammatory agents
SO CARBOHYDRATE RESEARCH
LA English
DT Article
DE Salidroside derivatives; Mirror isomers; t-glucose; Antioxidation;
   Anti-inflammatory
AB A series of derivatives of salidroside with mirror isomer glucose and different phenyl moieties were synthesized by Schmidt glycosylation in satisfactory yields, and their antioxidant and anti-inflammatory activities were evaluated by using LPS-induced RAW264.7 cells. One of the synthesized derivatives t -Sal -4 , bearing t-glycosyl and -OMe modification at the phenyl ring, exhibited high activity in inhibiting the production of proinflammatory cytokines and oxidative stress biomarker MDA as well as in enhancing the activity of SOD enzyme, compared with the natural product and its corresponding D-enantiomer. Further proteomic analysis suggested that t -Sal -4 exerted its anti-inflammatory activity through metabolic reprogramming. The in vitro activity showed that t -Sal -4 is a potent antioxidant and anti-inflammatory agent. Our finding indicated that the t-glucose-derived salidroside might be a promising lead compound in the development of salidroside derivatives as therapeutic agents.
C1 [Li, Zipeng; Sun, Ao; Wang, Xin; Abulimiti, Munila; Li, Zhongtang; Li, Zhongjun] Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
   [Li, Zhongjun] Peking Univ, Ningbo Inst Marine Med, Ningbo 315832, Peoples R China.
C3 Peking University; Peking University
RP Li, ZJ (corresponding author), Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
EM zjli@bjmu.edu.cn
OI Li, Zhongjun/0000-0003-1642-7773; Sun, Ao/0009-0009-3732-1514
FU National Key R & D Program of China [2022YFF1203005, 2022YFC2303700];
   National Natural Science Foundation of China [81930097, 82151223]
FX This project was supported by the National Key R & D Program of China
   (2022YFF1203005, 2022YFC2303700) , and supported by the National Natural
   Science Foundation of China (81930097, 82151223) .
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NR 21
TC 7
Z9 7
U1 3
U2 9
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0008-6215
EI 1873-426X
J9 CARBOHYD RES
JI Carbohydr. Res.
PD AUG
PY 2024
VL 542
AR 109174
DI 10.1016/j.carres.2024.109174
EA JUN 2024
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Chemistry
GA XT2T2
UT WOS:001263870500001
PM 38865798
DA 2026-05-27
ER

PT J
AU Palmeri, A
   Mammana, L
   Tropea, MR
   Gulisano, W
   Puzzo, D
AF Palmeri, Agostino
   Mammana, Leonardo
   Tropea, Maria Rosaria
   Gulisano, Walter
   Puzzo, Daniela
TI Salidroside, a Bioactive Compound of Rhodiola Rosea, Ameliorates Memory
   and Emotional Behavior in Adult Mice
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Adaptogen; anxiety; depression; memory; Rhodiola rosea; salidroside
ID STANDARDIZED EXTRACT SHR-5; L. EXTRACT; COGNITIVE IMPAIRMENT;
   DOUBLE-BLIND; PLACE PREFERENCE; STRESS; ANXIETY; ANTIOXIDANT;
   EXPRESSION; ADAPTOGENS
AB Rhodiola Rosea (R. Rosea) is a plant used in traditional popular medicine to enhance cognition and physical performance. R. Rosea medicinal properties have been related to its capability to act as an adaptogen, i.e., a substance able to increase the organism's resistance to a variety of chemical, biological, and physical stressors in a non-specific way. These adaptogen properties have been mainly attributed to the glycoside salidroside, one of the bioactive compounds present in the standardized extracts of R. Rosea. Here, we aimed to investigate whether a single dose of salidroside is able to affect memory and emotional behavior in wild type adult mice. We performed fear conditioning to assess cued and contextual memory, elevated plus maze and open field to evaluate anxiety, and tail suspension test to evaluate depression. Our results showed that a single i.p. administration of salidroside was able to enhance fear memory and exerted an anxiolytic and antidepressant effect. These data confirmed the adaptogenic effect of R. Rosea bioactive compounds in animal models and suggest that salidroside might represent an interesting pharmacological tool to ameliorate cognition and counteract mood disorders.
C1 [Palmeri, Agostino; Mammana, Leonardo; Tropea, Maria Rosaria; Gulisano, Walter; Puzzo, Daniela] Univ Catania, Dept Biomed & Biotechnol Sci, Physiol Sect, Viale A Doria 6 Ed 2, I-95125 Catania, Italy.
C3 University of Catania
RP Puzzo, D (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, Physiol Sect, Viale A Doria 6 Ed 2, I-95125 Catania, Italy.
EM danypuzzo@yahoo.it
RI ; PUZZO, Daniela/AAF-5026-2019; Tropea, Maria Rosaria/IAP-2664-2023
OI Mammana, Leonardo/0000-0002-5716-1548; PUZZO,
   Daniela/0000-0002-9542-2251; Gulisano, Walter/0000-0002-3415-3924;
   Tropea, Maria Rosaria/0000-0001-6343-6272
FU University Research Grant (FIR) of the University of Catania
FX This work was supported by the University Research Grant (FIR, 2014) of
   the University of Catania to A.P.
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NR 75
TC 28
Z9 36
U1 0
U2 31
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2016
VL 52
IS 1
BP 65
EP 75
DI 10.3233/JAD-151159
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DK6CK
UT WOS:000375008500007
PM 26967223
DA 2026-05-27
ER

PT J
AU Zhang, CX
   Pan, SN
   Tang, LL
   Ling, YS
   Zhou, XJ
   Feng, W
AF Zhang, Chengxi
   Pan, Sinian
   Tang, Leile
   Ling, Yesheng
   Zhou, Xiaojing
   Feng, Wei
TI Protective effects of salidroside on chronic heart failure in rats and
   the underlying mechanisms
SO BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Salidroside/protective effects; Chronic heart failure
ID BRAIN NATRIURETIC PEPTIDE; OXIDATIVE STRESS; APOPTOSIS; INTERLEUKIN-6;
   ACTIVATION; CASPASE-3; ALPHA
AB The present study aimed to investigate the protective effects of salidroside on chronic heart failure (CHF) in rats and to explore the underlying mechanisms. One hundred SD rats were randomly divided into sham-operated, model, and low-, medium- and high-dose salidroside groups. The CHF model was established in later 4 groups. The later 3 groups were intragastrically administrated with 6, 12 and 24 mg/kg salidroside, respectively, once a day, for continuous 4 weeks. Finally, the serum levels of brain natriuretic peptide (BNP) and interleukin 6 (IL-6), cardiac function indexes, and expression levels of myocardial cysteinyl aspartate-specific proteinase (Caspase)-3, Caspase-9, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein were determined. Results showed that, after treatment, compared with model group, in high-dose salidroside group the heart function indexes were significantly improved (P < 0.05), the serum levels of BNP and IL-6 were significantly decreased (P < 0.05), the expression levels of myocardial Caspase-3, Caspase-9 and MMP-1 protein were significantly decreased (P < 0.05), and the expression level of TIMP-1 protein was significantly increased (P < 0.05). In conclusion, salidroside has obvious protective effects on CHF in rats. The mechanisms may be related to its regulation of cardiomyocyte apoptosis and ventricular remodelingregulation related protein expressions.
C1 [Zhang, Chengxi; Tang, Leile; Ling, Yesheng] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiol, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China.
   [Pan, Sinian] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Pediat, Guangzhou, Guangdong, Peoples R China.
   [Zhou, Xiaojing; Feng, Wei] First Peoples Hosp Xinjiang Kashi Area, Dept Cardiol, Kashi, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Zhang, CX (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiol, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China.
EM zhangchengxi1@yeah.net
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NR 25
TC 0
Z9 0
U1 0
U2 17
PU UNIV SAO PAULO, CONJUNTO QUIMICAS
PI SAO PAULO
PA SERVICO PUBLICACOES E CIRCULACAO, CAIXA POSTAL 66083, SAO PAULO, 00000,
   BRAZIL
SN 1984-8250
EI 2175-9790
J9 BRAZ J PHARM SCI
JI Braz. J. Pharm. Sci.
PY 2019
VL 55
AR e18222
DI 10.1590/s2175-97902019000118222
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IR8FX
UT WOS:000481678300001
OA Green Submitted, Green Published, gold
DA 2026-05-27
ER

PT J
AU Yang, ZR
   Wang, HF
   Zuo, TC
   Guan, LL
   Dai, N
AF Yang, Ze-ran
   Wang, Hui-fang
   Zuo, Tie-cheng
   Guan, Li-li
   Dai, Ning
TI Salidroside alleviates oxidative stress in the liver with non- alcoholic
   steatohepatitis in rats
SO BMC PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
DE Salidroside; Oxidative stress; Non-alcoholic steatohepatitis; CYP2E1;
   Nox2
ID NONALCOHOLIC FATTY LIVER; CYTOCHROME-P450 2E1; DISEASE; MICE; STEATOSIS;
   EXTRACTS; ENZYMES; INJURY
AB Background: Nonalcoholic steatohepatitis (NASH) is characterized by fat accumulation in the hepatocyte, inflammation, liver cell injury, and varying degrees of fibrosis, and can lead to oxidative stress in liver. Here, we investigated whether Salidroside, a natural phenolic antioxidant product, can protect rat from liver injury during NASH.
   Methods: NASH model was established by feeding the male SD rats with high-fat and high-cholesterol diet for 14 weeks. Four groups of male SD rats including, normal diet control group, NASH model group, and Salidroside treatment group with 150 mg/kg and 300 mg/kg respectively, were studied. Salidroside was given by oral administration to NASH in rats from 9 weeks to 14 weeks. At the end of 14 weeks, liver and serum were harvested, and the liver injury, oxidative stress and histological features were evaluated.
   Results: NASH rats exhibited significant increases in the following parameters as compared to normal diet control rats: fat droplets with foci of inflammatory cell infiltration in the liver. ALT, AST in serum and TG, TC in hepatocyte elevated. Oxidative responsive genes including CYP2E1 and Nox2 increased. Additionally, NASH model decreased antioxidant enzymes SOD, GSH, GPX, and CAT in the liver due to their rapid depletion after battling against oxidative stress. Compared to NASH model group, treatment rats with Salidroside effectively reduced lipid accumulation, inhibited liver injury in a does-dependent manner. Salidroside treatment restored antioxidant enzyme levels, inhibited expression of CYP2E1 and Nox2 mRNA in liver, which prevented the initial step of generating free radicals from NASH.
   Conclusion: The data presented here show that oral administration of Salidroside prevented liver injury in the NASH model, likely through exerting antioxidant actions to suppress oxidative stress and the free radical-generating CYP2E1 enzyme, Nox2 in liver.
C1 [Yang, Ze-ran; Wang, Hui-fang; Zuo, Tie-cheng; Dai, Ning] Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, 222 Zhongshan Rd, Dalian 116011, Liaoning Provin, Peoples R China.
   [Guan, Li-li] Dalian Med Univ, Dept Digest Physiol, Dalian 116011, Liaoning Provin, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Dai, N (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, 222 Zhongshan Rd, Dalian 116011, Liaoning Provin, Peoples R China.
EM dainingdn@live.com
FU Liaoning province nature science fund [201102 051]
FX This project was supported by Liaoning province nature science fund
   (201102 051).
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NR 27
TC 50
Z9 58
U1 2
U2 30
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2050-6511
J9 BMC PHARMACOL TOXICO
JI BMC Pharmacol. Toxicol.
PD APR 14
PY 2016
VL 17
AR 16
DI 10.1186/s40360-016-0059-8
PG 6
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA DK2IB
UT WOS:000374736800001
PM 27075663
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, XL
   Sun, RX
   Li, DX
   Chen, ZG
   Li, XF
   Sun, SY
   Lin, F
   Zhao, GA
AF Wang, Xiu-Long
   Sun, Rui-Xiang
   Li, Dong-Xu
   Chen, Zhi-Gang
   Li, Xue-Fang
   Sun, Si-Yu
   Lin, Fei
   Zhao, Guo-An
TI Salidroside Regulates Mitochondrial Homeostasis After Polarization of
   RAW264.7 Macrophages
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE salidroside; mitochondrial homeostasis; macrophage polarization;
   inflammation; NF-kappa B signaling
ID OXIDATIVE STRESS; ATHEROSCLEROSIS; INFLAMMATION; INJURY
AB Salidroside has anti-inflammatory and antiatherosclerotic effects, and mitochondrial homeostasis imbalance is closely related to cardiovascular disease. The aim of this study was to investigate the effect of salidroside on mitochondrial homeostasis after macrophage polarization and elucidate its possible mechanism against atherosclerosis. RAW264.7 cells were stimulated with 1 mu g & BULL;mL(-1) Lipopolysaccharide and 50 ng & BULL;mL(-1) IFN-gamma establish M1 polarization and were also pretreated with 400 mu M salidroside. The relative expression of proinflammatory genes was detected by RT-PCR whereas that of mitochondrial homeostasis-related proteins and nuclear factor kappa-B (NF-kappa B) was detected by WB. Levels of intracellular reactive oxygen species (ROS), mitochondrial membrane potential, and mass were measured by chemifluorescence whereas that of NF-kappa B nuclear translocation was detected by immunofluorescence. Compared with the M phi group, the M1 group demonstrated increased mRNA expression of interleukin-1 beta , inductible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha ; increased protein expression of iNOS, NOD-like receptor protein 3, putative kinase 1 , and NF-kappa B p65 but decreased protein expression of MFN2, Tom20, and PGC-1 alpha; decreased mitochondrial membrane potential and mass; and increased ROS levels and NF-kappa B p65 nuclear translocation. Salidroside intervention decreased mRNA expression of interleukin-1 beta and tumor necrosis factor-alpha compared with the M1 group but did not affect that of iNOS. Furthermore, salidroside intervention prevented the changes in protein expression, mitochondrial membrane potential and mass, ROS levels, and NF-kappa B p65 nuclear translocation observed in the M1 group. In summary, salidroside ultimately inhibits M1 macrophage polarization and maintains mitochondrial homeostasis after macrophage polarization by increasing mitochondrial membrane potential, decreasing ROS levels, inhibiting NF-kappa B activation, and in turn regulating the expression of proinflammatory factors and mitochondrial homeostasis-associated proteins.
C1 [Wang, Xiu-Long; Sun, Rui-Xiang; Li, Dong-Xu; Chen, Zhi-Gang; Li, Xue-Fang; Sun, Si-Yu; Lin, Fei; Zhao, Guo-An] Xinxiang Med Coll, Life Sci Res Ctr, Henan Int Joint Lab Cardiovasc Injury & Repair, Henan Heart Mitochondrial Biomed Engn Res Ctr,Affi, Xinxiang City, Peoples R China.
   [Zhao, Guo-An] Xinxiang Med Coll, Affiliated Hosp 1, Hlth Rd 88, Xinxiang City 453100, Henan Province, Peoples R China.
   [Lin, Fei] Xinxiang Med Coll, Res Ctr Biol Sci, Affiliated Hosp 1, Hlth Rd 88, Xinxiang City 453100, Henan Province, Peoples R China.
C3 Henan Medical University; Henan Medical University; Henan Medical
   University
RP Zhao, GA (corresponding author), Xinxiang Med Coll, Affiliated Hosp 1, Hlth Rd 88, Xinxiang City 453100, Henan Province, Peoples R China.; Lin, F (corresponding author), Xinxiang Med Coll, Res Ctr Biol Sci, Affiliated Hosp 1, Hlth Rd 88, Xinxiang City 453100, Henan Province, Peoples R China.
EM wangxiulong001@163.com; 1797789044@qq.com; 781783662@qq.com;
   czgdoctor@163.com; 1217151273@qq.com; linfeixixi@aliyun.com;
   guoanzhao@xxmu.edu.cn
RI LI, DONGXU/GNM-6998-2022
FU Key Scientific Research Project Plan of Henan Higher Education
   Institutions [21A320012, LHGJ20190442]; Science and Technology Research
   Plan of Henan Provincial Department of Science and Technology
   [22A360017]; Joint Construction Project of Henan Medical Science and
   Technology Research Program [LHGJ20190468, 212102310350]; Key R&D and
   Promotion Project of Henan Province;  [LHGJ20190441]
FX Supported by the Key Scientific Research Project Plan of Henan Higher
   Education Institutions (21A320012), the Science and Technology Research
   Plan of Henan Provincial Department of Science and Technology
   (212102310350), the Joint Construction Project of Henan Medical Science
   and Technology Research Program (LHGJ20190441, LHGJ20190442), the Key
   R&D and Promotion Project of Henan Province (212102310350), and the Key
   Scientific Research Project Plan of Henan Higher Education Institutions
   (21A320012, 22A360017,LHGJ20190468).
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NR 38
TC 15
Z9 17
U1 1
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD JAN
PY 2023
VL 81
IS 1
BP 85
EP 92
DI 10.1097/FJC.0000000000001362
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 7W9IO
UT WOS:000913820000012
PM 36027482
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Alameddine, A
   Fajloun, Z
   Bourreau, J
   Gauquelin-Koch, G
   Yuan, M
   Gauguier, D
   Derbre, S
   Ayer, A
   Custaud, MA
   Navasiolava, N
AF Alameddine, A.
   Fajloun, Z.
   Bourreau, J.
   Gauquelin-Koch, G.
   Yuan, M.
   Gauguier, D.
   Derbre, S.
   Ayer, A.
   Custaud, M. A.
   Navasiolava, N.
TI THE CARDIOVASCULAR EFFECTS OF SALIDROSIDE IN THE GOTO-KAKIZAKI DIABETIC
   RAT MODEL
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE type 2 diabetes; salidroside; telemetry; Rhodiola rosea; vascular
   function; glucose intolerance; nitric oxide; hypertension; guanylyl
   cyclase
ID RHODIOLA-ROSEA L.; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; GUANYLYL-CYCLASE;
   GK RAT; DYSFUNCTION; GLUCOSE; HYPERTENSION; VASODILATION; METABOLISM
AB Many factors, including hyperglycemia, hypertension, obesity, dyslipidemia, and a sedentary lifestyle, contribute to a high prevalence of cardiovascular disease. Specific vascular impairment treatments in the context of diabetes and vascular risk need to be improved. Salidroside is the primary active component of Rhodiola rosea and has documented antioxidative, cardioprotective, and vasculoprotective properties. The aim of this study was to test the hypothesis that salidroside has protective effects against hyperglycemia, hypertension, and vasodilation impairment in the Goto-Kakizaki (GK) rat model of diabetes. We evaluated cardiovascular parameters (e.g., daytime/nighttime systolic and diastolic blood pressure, heart rate, and activity), metabolic parameters (e.g., body weight, food and water consumption, serum fructosamine level, glucose tolerance), eNOS / phospho-eNOS expression level and in vitro vascular reactivity of aorta and second-order mesenteric arteries in Wistar-Kyoto (control) and GK (diabetic) rats treated with salidroside (40 mg/kg) or placebo (water) for 5 weeks. GK rats showed hypertension, marked glucose intolerance, and impaired endothelium-dependent and endothelium-independent vasodilation capacity. Salidroside showed beneficial effects on endothelial and non-endothelial vasodilation and likely acts on the endothelium and smooth muscle cells through the soluble guanylyl cyclase pathway. Despite its vascular effects, salidroside had no effect on blood pressure and heart rate in GK and control rats, it did not improve glucose metabolism or limit hypertension in the GK model of type 2 diabetes.
C1 [Alameddine, A.; Bourreau, J.; Ayer, A.; Custaud, M. A.; Navasiolava, N.] Univ Angers, Fac Med, INSERM 1083, UMR CNRS 6214, F-49045 Angers, France.
   [Fajloun, Z.] Lebanese Univ, Doctoral Sch Sci & Biotechnol, AZM Ctr Res Biotechnol, Tripoli, Yemen.
   [Gauquelin-Koch, G.] CNES, Paris, France.
   [Yuan, M.] China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing, Peoples R China.
   [Gauguier, D.] Univ Paris 06, Inst Cardiometab & Nutr, Hosp Pitie, Paris, France.
   [Derbre, S.] Univ Angers, SFR QUASAV, EA SONAS 921, F-49045 Angers, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers; Centre National d'Etudes Spatiales (CNES); Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Universite d'Angers
RP Navasiolava, N (corresponding author), Univ Angers, UFR Med, INSERM 1083, UMR CNRS 6214, Rue Haute Reculee, F-49045 Angers, France.
EM nastassia.navasiolava@chu-angers.fr
RI Gauguier, Dominique/G-2190-2016; Fajloun, Ziad/AAO-8595-2021; DERBRE,
   Séverine/AAJ-4904-2021; Custaud, Marc-Antoine/K-1376-2015; Navasiolava,
   Nastassia/AAU-8149-2020
OI Gauguier, Dominique/0000-0001-6156-9530; Fajloun,
   Ziad/0000-0002-6502-3110; BOURREAU, Jennifer/0009-0007-7239-6373;
   DERBRE, Séverine/0000-0002-3953-5745; 
FU CNES; French Space Agency; regional council "Region des Pays de la
   Loire"
FX This work was supported by CNES, the French Space Agency. Asmaa
   Alameddine is the recipient of a Ph.D. Grant from CNES and the regional
   council "Region des Pays de la Loire".
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NR 53
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Z9 38
U1 0
U2 9
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD APR
PY 2015
VL 66
IS 2
BP 249
EP 257
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CH6OC
UT WOS:000354154900009
PM 25903955
DA 2026-05-27
ER

PT J
AU Si, XJ
   Wang, CL
   Li, L
   Ye, DX
   Wei, YL
   Ding, YP
AF Si, Xiaojing
   Wang, Chaolin
   Li, Li
   Ye, Daixin
   Wei, Youli
   Ding, Yaping
TI Preparation of nickel-aluminum hydrotalcite nanosheet-coated carbon
   nanofibers and their application in the detection of salidroside
SO MICROCHEMICAL JOURNAL
LA English
DT Article
DE Electrochemical sensor; Hydrotalcite nanosheet; Ni-Al; Salidroside
ID LAYERED DOUBLE HYDROXIDES; RHODIOLA
AB A facile and highly sensitive electrochemical sensor for salidroside was fabricated based on multilayer ultrathin films (UTFs) containing Ni-Al layered double hydroxide (LDH) and carbon fibers that obtained by electrospinning technology. The X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscopy (TEM) images show that the film surface is synthesized successfully. In addition, we constructed the electrochemical sensor using the composite nanomaterials we prepared to achieve detection of salidroside and this sensor showed a good linear range (0.2-120 mu M) and a low detection limit (0.067 mu M). It has also been successfully applied to the detection of actual samples, compared with HPLC method, satisfactory recovery rates have also been obtained.
C1 [Si, Xiaojing] Shanghai Business Sch, Dept Food, Shanghai 200235, Peoples R China.
   [Wang, Chaolin; Li, Li; Ye, Daixin; Ding, Yaping] Shanghai Univ, Sch Sci, Dept Chem, Shanghai 200444, Peoples R China.
   [Wang, Chaolin; Wei, Youli] Shanghai Aurora Coll, Sch Publ Hlth, Shanghai 201908, Peoples R China.
C3 Shanghai Business School; Shanghai University
RP Ding, YP (corresponding author), Shanghai Univ, Sch Sci, Dept Chem, Shanghai 200444, Peoples R China.
EM wdingyp@sina.com
RI li, li/GPX-3938-2022
FU National Natural Science Foundation of China [21671132]
FX This paper is funded by the National Natural Science Foundation of China
   (No: 21671132).
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NR 25
TC 6
Z9 6
U1 1
U2 61
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0026-265X
EI 1095-9149
J9 MICROCHEM J
JI Microchem J.
PD JUN
PY 2020
VL 155
AR 104652
DI 10.1016/j.microc.2020.104652
PG 7
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA LF4EG
UT WOS:000527371500004
DA 2026-05-27
ER

PT J
AU Tian, FF
   Guan, L
   Ye, LL
   Zhang, S
   Shan, PY
AF Tian, Fangfang
   Guan, Lin
   Ye, Lili
   Zhang, Shuai
   Shan, Peiyan
TI Alleviating Effect of Salidroside on Cognitive Impairment due to
   Post-Traumatic Stress Disorder in Rats and the Mechanism
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE apoptosis; c-fos; 5-hydroxytryptamine; oxidative stress; post-traumatic
   stress disorder; salidroside
ID RHODIOLA-ROSEA-L.; PREFRONTAL CORTEX; MODEL; EXPRESSION; RESPONSES;
   SYMPTOMS; CELLS; BCL-2; BAX
AB The effect of salidroside on cognitive impairment due to post-traumatic stress disorder (PTSD) in rats and the mechanism were investigated. The rats were randomized into control, model, and 20, 40. and 80 mg/kg salidroside groups. PTSD model was established in later four groups, and then the later three groups were treated with 20, 40. and 80 mg/kg salidroside groups for 2 weeks, respectively. After treatment, compared with model groups, in 40 and 80 mg/kg salidroside groups the open-field test, elevated cross-maze test. and Morris water maze test outcomes were significantly improved (P < 0.05), the serum superoxide dismutase level was significantly increased (P < 0.05), the malondialdehyde level was significantly decreased (P < 0.05), the hippocampus 5-hydroxytryptamine level was significantly increased (P < 0.05), the c-fos protein level was significantly decreased (P < 0.05), the B-cell lymphoma-2 protein expression level was significantly increased (P < 0.05), and the B-cell lymphoma-2 associated X protein expression level was significantly decreased (P < 0.05). Salidroside can alleviating the cognitive impairment due to PTSD in rats, and the mechanisms may be related to its reducing oxidative stress, regulating 5-hydroxytryptamine and c-fos protein levels and antagonizing hippocampus neuron apoptosis.
C1 [Tian, Fangfang] Shandong Univ, Qilu Hosp, Jinan 250012, Peoples R China.
   [Tian, Fangfang; Guan, Lin; Ye, Lili; Zhang, Shuai] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Special Examinat, Jinan 250011, Peoples R China.
   [Shan, Peiyan] Shandong Univ, Qilu Hosp, Dept Geriatr, Jinan 250012, Peoples R China.
C3 Shandong University; Shandong University of Traditional Chinese
   Medicine; Shandong University
RP Shan, PY (corresponding author), Shandong Univ, Qilu Hosp, Dept Geriatr, Jinan 250012, Peoples R China.
EM peiyanshan@126.com
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NR 30
TC 0
Z9 0
U1 0
U2 2
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2020
VL 39
IS 3
BP 596
EP 603
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KZ3UE
UT WOS:000523190000024
DA 2026-05-27
ER

PT J
AU Yan, FY
   Liu, RC
   Zhuang, XY
   Li, RS
   Shi, HM
   Gao, XF
AF Yan, Fangying
   Liu, Rongchen
   Zhuang, Xinyu
   Li, Ruoshui
   Shi, Haiming
   Gao, Xiufang
TI Salidroside Attenuates Doxorubicin-Induced Cardiac Dysfunction Partially
   Through Activation of QKI/FoxO1 Pathway
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Article
DE Salidroside; Doxorubicin; Quaking; FoxO1; Apoptosis
ID ANTHRACYCLINE-INDUCED CARDIOTOXICITY; RNA-BINDING; IN-VITRO; INJURY;
   STRESS; CELLS
AB Doxorubicin (DOX) is an effective chemotherapy. However, its usage has been associated with adverse effects. Salidroside (SAL) is an antioxidative drug, which confers protective effects against several diseases. Salidroside can attenuate cardiac dysfunction induced by DOX. Quaking (QKI) is identified as a protective factor that can inhibit cardiotoxicity medicated by DOX through the regulation of cardiac circular RNA expression. The present study investigated the role of QKI on the protective effect of SAL in the DOX-induced cardiotoxicity model. Results indicated that SAL attenuated DOX-induced adverse effects, including cardiac dysfunction, weight loss, and reactive oxygen species (ROS) production, and decreased the expression of BAX, caspase 3, and FoxO1. Also, it increased the Mn-SOD2 and QKI expression in vivo and in vitro. Furthermore, QKI knockdown suppressed anti-cardiotoxicity mediated by SAL. In conclusion, the results of the current study show that salidroside attenuates doxorubicin-induced cardiac dysfunction through activation of QKI/FoxO1 pathway.
C1 [Yan, Fangying; Liu, Rongchen; Zhuang, Xinyu; Li, Ruoshui; Shi, Haiming; Gao, Xiufang] Fudan Univ, Huashan Hosp, Dept Cardiol, 12 Middle Wulumuqi Rd, Shanghai 200000, Peoples R China.
C3 Fudan University
RP Shi, HM; Gao, XF (corresponding author), Fudan Univ, Huashan Hosp, Dept Cardiol, 12 Middle Wulumuqi Rd, Shanghai 200000, Peoples R China.
EM shihaiming_hs@163.com; gaoxf_fudan@126.com
RI ; Zhuang, Xinyu/KQU-2437-2024
OI Li, Ruoshui/0000-0003-3922-686X; 
FU National Natural Science Foundation of China [81573711, 81573710]
FX This study was funded by the National Natural Science Foundation of
   China (grant number 81573711, 81573710).
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NR 33
TC 28
Z9 33
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1937-5387
EI 1937-5395
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD APR
PY 2021
VL 14
IS 2
BP 355
EP 364
DI 10.1007/s12265-020-10056-x
EA JUL 2020
PG 10
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA RM7YH
UT WOS:000548827100001
PM 32671648
DA 2026-05-27
ER

PT J
AU Liang, Q
   Guo, RJ
   Tsao, JR
   He, Y
   Wang, CC
   Jiang, JX
   Zhang, D
   Chen, TG
   Yue, TT
   Hu, K
AF Liang, Qi
   Guo, Rongjie
   Tsao, Jia-Ruei
   He, Yun
   Wang, Chenchen
   Jiang, Jiaxuan
   Zhang, Di
   Chen, Taige
   Yue, Tingting
   Hu, Kai
TI Salidroside alleviates oxidative stress in dry eye disease by activating
   autophagy through AMPK-Sirt1 pathway
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Dry eye disease; Oxidative stress; Autophagy; Nrf2; AMPK-Sirt1
ID AMPK
AB Dry eye disease (DED) is a multifactorial disease, and oxidative stress plays a crucial role in its pathogenesis. Recently, multiple studies have shown that upregulation of autophagy can protect the cornea from oxidative stress damage. The present study investigated the therapeutic effects of salidroside, the main component of Rhodiola crenulata, in both in vivo and in vitro dry eye models. The results showed that topical eye drop treatment with salidroside restored corneal epithelium damage, increased tear secretion, and reduced cornea inflammation in the DED mice. Salidroside activated autophagy through AMP-activated protein kinase (AMPK)-sirtuin-1 (Sirt1) signaling pathway, which promoted the nuclear translocation of nuclear factor erythroid-2-related factor 2 (Nrf2) and increased the expression of downstream antioxidant factors heme oxygenase-1 (HO-1) and NAD(P)H quinone dehydrogenase 1 (NQO1). This process restored antioxidant enzyme activity, reduced reactive oxygen species (ROS) accumulation, and alleviated oxidative stress. The application of autophagy inhibitor chloroquine and AMPK inhibitor Compound C reversed the therapeutic efficacy of salidroside, validating the above findings. In conclusion, our data suggest that salidroside is a promising candidate for DED treatment.
C1 [Liang, Qi; Guo, Rongjie; Tsao, Jia-Ruei; He, Yun; Jiang, Jiaxuan; Zhang, Di; Chen, Taige; Hu, Kai] Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Ophthalmol, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China.
   [Wang, Chenchen] Wenzhou Med Univ, Eye Hosp, Natl Clin Res Ctr Ocular Dis, 618 Fengqi East Rd, Hangzhou, Zhejiang, Peoples R China.
   [Chen, Taige] Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Rheumatol & Immunol, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China.
   [Yue, Tingting] Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Neurosurg, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing University; Wenzhou Medical University; Nanjing University;
   Nanjing University
RP Hu, K (corresponding author), Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Ophthalmol, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China.; Yue, TT (corresponding author), Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Neurosurg, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China.
EM yuett0918@163.com; kai_hu@nju.edu.cn
RI ; Jiang, Jiaxuan/LXV-1860-2024
OI wang, chenchen/0009-0004-7200-5190; Chen, Taige/0000-0003-1660-1348;
   Jiang, Jiaxuan/0000-0002-7889-5209
FU National Natural Science Foundation of China [81870695]; Natural Science
   Foundation of Jiangsu Province [SBK2020022490]; Nanjing Science and
   Technology Development Plan [ZKX20022, YKK21095]; Affiliated Drum Tower
   Hospital, Medical School of Nanjing University [2022-LCYJ-MS-36]
FX This article was supported by grants from the National Natural Science
   Foundation of China (81870695), Natural Science Foundation of Jiangsu
   Province (SBK2020022490), Key Program of Nanjing Science and Technology
   Development Plan (ZKX20022), General Program of Nanjing Science and
   Technology Development Plan (YKK21095) and Fundings for Clinical Trials
   from the Affiliated Drum Tower Hospital, Medical School of Nanjing
   University (2022-LCYJ-MS-36).
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NR 72
TC 46
Z9 49
U1 7
U2 42
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD AUG
PY 2023
VL 121
AR 110397
DI 10.1016/j.intimp.2023.110397
EA JUN 2023
PG 13
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA N2SZ8
UT WOS:001035586100001
PM 37302369
OA hybrid
DA 2026-05-27
ER

PT J
AU Zhu, T
   Liu, H
   Gao, SM
   Jiang, N
   Chen, S
   Xie, WJ
AF Zhu, Ting
   Liu, Hui
   Gao, Shiman
   Jiang, Ning
   Chen, Shuai
   Xie, Weijie
TI Effect of salidroside on neuroprotection and psychiatric sequelae during
   the COVID-19 pandemic: A review
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Psychiatric sequelae; Salidroside; Neuroprotection; Mental disorder;
   Neuroinflammation; Brain plasticity
ID RHODIOLA-ROSEA L.; MENTAL-HEALTH-SERVICES; MESENCHYMAL STEM-CELLS;
   MPP+-INDUCED APOPTOSIS; INDUCED RAT MODEL; ALZHEIMERS-DISEASE; COGNITIVE
   IMPAIRMENT; ALTERNATIVE MEDICINE; PARKINSONS-DISEASE; OXIDATIVE STRESS
AB The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and the risk of psychiatric sequelae and consequent mental disorders has increased among the general population, health care workers and patients with COVID-19. Achieving effective and widespread prevention of pandemic-related psychiatric sequelae to protect the mental health of the global population is a serious challenge. Salidroside, as a natural agent, has substantial pharmacological activity and health effects, exerts obvious neuroprotective effects, and may be effective in preventing and treating psychiatric sequelae and mental disorders resulting from stress stemming from the COVID-19 pandemic. Herein, we systematically summarise, analyse and discuss the therapeutic effects of salidroside in the prevention and treatment of psychiatric sequelae as well as its roles in preventing the progression of mental disorders, and fully clarify the potential of salidroside as a widely applicable agent for preventing mental disorders caused by stress; the mechanisms underlying the potential protective effects of salidroside are involved in the regulation of the oxidative stress, neuroinflammation, neural regeneration and cell apoptosis in the brain, the network homeostasis of neurotransmission, HPA axis and cholinergic system, and the improvement of synaptic plasticity. Notably, this review innovatively proposes that salidroside is a potential agent for treating stress-induced health issues during the COVID-19 pandemic and provides scientific evidence and a theoretical basis for the use of natural products to combat the current mental health crisis.
C1 [Zhu, Ting] Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Sch Basic Med, Dept Pathophysiol, Qingdao 266071, Peoples R China.
   [Xie, Weijie] Tongji Univ, Clin Res Ctr Mental Disorders, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai 200122, Peoples R China.
   [Jiang, Ning] Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China.
   [Chen, Shuai] Wuhan Univ, Sch Publ Hlth, Donghu Rd 115, Wuhan 430071, Peoples R China.
   [Liu, Hui] Guizhou Med Univ, Guizhou Prov Key Lab Pharmaceut, Guiyang 550004, Guizhou, Peoples R China.
   [Liu, Hui] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Guizhou, Peoples R China.
   [Liu, Hui] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Minist Educ, Guiyang 550004, Guizhou, Peoples R China.
   [Gao, Shiman] Qingdao Univ, Women & Childrens Hosp, Dept Clin Pharm, Qingdao 266034, Peoples R China.
   [Xie, Weijie] Tongji Univ, Clin Res Ctr Mental Disorders, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.
C3 Qingdao University; Tongji University; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Institute of Medicinal Plant Development - CAMS; Wuhan University;
   Guizhou Medical University; Guizhou Medical University; Guizhou Medical
   University; Qingdao University; Tongji University
RP Jiang, N (corresponding author), Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China.; Chen, S (corresponding author), Wuhan Univ, Sch Publ Hlth, Donghu Rd 115, Wuhan 430071, Peoples R China.; Xie, WJ (corresponding author), Tongji Univ, Clin Res Ctr Mental Disorders, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.
EM jiangning0603@163.com; chenshuai2016@hotmail.com; xwjginseng@126.com
RI Chen, Shuai/AAO-7459-2020; Xie, Weijie/AAN-5858-2020
FU Discipline Project of Shanghai Pudong [PWYgy2021-02]
FX Discipline Project of Shanghai Pudong (Grant No.: PWYgy2021-02) . We
   express our sincere gratitude to these foundations.
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NR 201
TC 9
Z9 10
U1 4
U2 17
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2024
VL 170
AR 115999
DI 10.1016/j.biopha.2023.115999
EA DEC 2023
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EB2S9
UT WOS:001136387900001
PM 38091637
OA gold
DA 2026-05-27
ER

PT J
AU Wang, JT
   Yang, ZQ
   Feng, ZL
   Zhao, HB
   Duan, CX
   Sheng, YZ
   Du, PF
   Chen, W
   Chen, QJ
   Xiao, D
AF Wang, Juntao
   Yang, Zhaoqi
   Feng, Zili
   Zhao, Hongbo
   Duan, Congxue
   Sheng, Yunzhi
   Du, Pengfei
   Chen, Wang
   Chen, Qingjuan
   Xiao, Dong
TI Synthesis of Salidroside Derivatives at C4 Position of Benzene Ring and
   Its Effect on Hep3B Cell Viability
SO CHEMICAL BIOLOGY & DRUG DESIGN
LA English
DT Article
DE antitumor drugs; derivative; Hep3B cell activity; liver cancer;
   salidroside
ID CANCER
AB Salidroside has been reported to have various pharmacological activities, including hypoxia tolerance, anti-radiation, and antitumor. In this study, we studied the antitumor activity of salidroside ether derivatives in the human hepatocellular carcinoma cell line Hep3B. We created eleven new benzyl halide derivatives called S1-S11 by modifying the phenolic hydroxyl groups at the C4 position of salidroside. The compounds were shown to inhibit tumor proliferation in the in vitro CCK-8 assay. Compounds S4, S5, S6, S7, S8, and S11 demonstrated strong inhibitory activity anti-human hepatic cancer cell Hep3B, with IC50 values of 67.89, 97.55, 73.67, 57.92, 88.29, and 33.39 mu M, respectively. Under the inverted microscope, compared with the blank group, after 48 h of administration, it showed obvious proliferation inhibition and apoptosis characteristics. In addition, network pharmacology predicts that these derivatives may have the effect of regulating the nervous system and protecting neuronal cells without violating Lipinski's Rule. In summary, the benzyl halide modification on the C4 phenolic hydroxyl group on the benzene ring of SAL can improve its antitumor activity, which provides ideas for the subsequent development of salidroside antitumor drugs.
C1 [Wang, Juntao; Yang, Zhaoqi; Feng, Zili; Zhao, Hongbo; Duan, Congxue; Sheng, Yunzhi; Du, Pengfei; Chen, Wang] Shaanxi Univ Technol, Coll Biol Sci & Engn, Hanzhong, Peoples R China.
   [Wang, Juntao; Yang, Zhaoqi; Feng, Zili; Duan, Congxue; Sheng, Yunzhi; Du, Pengfei; Chen, Wang] Qinba Biol Resources & Ecol Environm Prov & Minist, Hanzhong, Peoples R China.
   [Feng, Zili; Zhao, Hongbo; Duan, Congxue; Chen, Wang] Shaanxi Prov Engn Technol Res Ctr Industrializat N, Hanzhong, Peoples R China.
   [Feng, Zili] Shaanxi Cuicheng Biomed Technol Co Ltd, Hanzhong, Peoples R China.
   [Zhao, Hongbo] South China Agr Univ, Coll Hort, Guangzhou, Peoples R China.
   [Chen, Qingjuan; Xiao, Dong] 3201 Hosp, Dept Orthoped, Hanzhong 723000, Shaanxi, Peoples R China.
C3 Shaanxi University of Technology; South China Agricultural University
RP Feng, ZL (corresponding author), Shaanxi Univ Technol, Coll Biol Sci & Engn, Hanzhong, Peoples R China.; Feng, ZL (corresponding author), Qinba Biol Resources & Ecol Environm Prov & Minist, Hanzhong, Peoples R China.; Feng, ZL (corresponding author), Shaanxi Prov Engn Technol Res Ctr Industrializat N, Hanzhong, Peoples R China.; Feng, ZL (corresponding author), Shaanxi Cuicheng Biomed Technol Co Ltd, Hanzhong, Peoples R China.
EM fengzili@snut.edu.cn
FU Key R&D Program in Shaanxi Province (No. 2022SF-406)
FX This work was supported by Qinba Key Laboratory of Biological Resources
   and Ecological Environment (Cultivation) "City-School Co-Construction"
   Scientific Research Project (No. SXZC-2302); Key R&D Program Project in
   Shaanxi Province (No. 2022SF-406).
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NR 26
TC 1
Z9 1
U1 2
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-0277
EI 1747-0285
J9 CHEM BIOL DRUG DES
JI Chem. Biol. Drug Des.
PD JUN 26
PY 2025
VL 105
IS 6
AR e70131
DI 10.1111/cbdd.70131
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 4GQ2S
UT WOS:001517558300001
PM 40574318
DA 2026-05-27
ER

PT J
AU Sharma, N
   Mishra, KP
   Ganju, L
AF Sharma, Navita
   Mishra, K. P.
   Ganju, Lilly
TI Salidroside exhibits anti-dengue virus activity by upregulating host
   innate immune factors
SO ARCHIVES OF VIROLOGY
LA English
DT Article
ID RIG-I; MECHANISMS; TARGETS
AB Dengue is an arboviral disease with no effective therapy available. Therefore, there is an urgent need to find a potent antiviral agent against dengue virus (DENV). In the present study, salidroside, a main bioactive compound of Rhodiola rosea, was evaluated for its antiviral potential against DENV serotype-2 infection and its effect on host innate immune factors. Antiviral effects of salidroside were examined in DENV-infected cells by western blotting, flow cytometry and real-time PCR. Its underlying mechanism involved in antiviral action was determined by evaluating expression of host innate immune factors including RIG-I, IRF-3, IRF-7, PKR, P-eIF2 alpha and NF-kappa B. Salidroside potently inhibited DENV infection by decreasing DENV envelope protein expression more than tenfold. Salidroside exerts its antiviral activity by increasing expression of RNA helicases such as RIG-I, thereby initiating a downstream signaling cascade that induces upregulation of IRF-3 and IRF-7. It prevents viral protein synthesis by increasing the expression of PKR and P-eIF2 alpha while decreasing NF-kappa B expression. It was also found to induce the expression of IFN-alpha. In addition, the number of NK cells and CD8(+) T cells were also found to be increased by salidroside treatment in human PBMCs, which are important in limiting DENV replication during early stages of infection. The findings presented here suggest that salidroside exhibits antiviral activity against DENV by inhibiting viral protein synthesis and boosting host immunity by increasing the expression of host innate immune factors and hence could be considered for the development of an effective therapeutic agent against DENV infection.
C1 [Sharma, Navita; Mishra, K. P.; Ganju, Lilly] DRDO, DIPAS, Immunomodulat Lab, Lucknow Rd, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS)
RP Mishra, KP (corresponding author), DRDO, DIPAS, Immunomodulat Lab, Lucknow Rd, Delhi 110054, India.
EM kpmpgi@rediffmail.com
RI ; Ganju, Lilly/LZI-4336-2025
OI Mishra, KP/0000-0002-8371-3772; 
FU Defense Research & Development Organization (DRDO), Ministry of Defence,
   Government of India [DIP-264]; Council of Scientific and Industrial
   research
FX The authors thank the Defense Research & Development Organization
   (DRDO), Ministry of Defence, Government of India, for financial support
   in the form of DIP-264. NS thanks the Council of Scientific and
   Industrial research for providing a fellowship in the form of a junior
   and senior research fellowship.
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NR 31
TC 31
Z9 32
U1 0
U2 31
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
EI 1432-8798
J9 ARCH VIROL
JI Arch. Virol.
PD DEC
PY 2016
VL 161
IS 12
BP 3331
EP 3344
DI 10.1007/s00705-016-3034-1
PG 14
WC Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Virology
GA DZ7TB
UT WOS:000386068400004
PM 27581807
DA 2026-05-27
ER

PT J
AU Shi, LL
   Wang, CY
   Zhou, XJ
   Zhang, YX
   Liu, YJ
   Ma, C
AF Shi, Lingling
   Wang, Caiyun
   Zhou, Xiaojing
   Zhang, Yanxia
   Liu, Yujun
   Ma, Chao
TI Production of salidroside and tyrosol in cell suspension cultures of
   Rhodiola crenulata
SO PLANT CELL TISSUE AND ORGAN CULTURE
LA English
DT Article
DE Rhodiola crenulata; Cell suspension cultures; Salidroside; Tyrosol;
   L-phenylalanine ammonia lyase; beta-D-glucosidase
ID THIDIAZURON; ROSEA; SACHALINENSIS; RADIX; ACID
AB Salidroside and its aglycone tyrosol are important compounds found in Rhodiola plants. In this study, callus derived from Rhodiola crenulata was induced and grown when explants were incubated on a Murashige and Skoog (MS) medium containing various concentrations of 6-benzyaldenine (BA), naphthalene acetic acid (NAA) and thidiazuron (TDZ). Callus was easily initiated from juvenile leaves in half strength MS medium supplemented with 0.5 mg/L BA and 3.0 mg/L NAA, while full strength MS containing 0.5 mg/L TDZ and 0.5 mg/L NAA was the best for callus subculture and subsequent cell suspension culture. The activities of l-phenylalanine ammonia lyase (PAL) and beta-d-glucosidase, two key enzymes in salidroside synthesis, increased at first and subsequently decreased in cell suspension cultures. The salidroside and tyrosol levels in the cell suspension cultures were determined using high-performance liquid chromatography. High levels of salidroside and tyrosol were detected in cell suspension cultures of R. crenulata extracted with 75 % methanol, demonstrating that the biotechnological production of these compounds using plant cell suspension cultures derived from R. crenulata may be an attractive alternative to harvest-based production.
C1 [Shi, Lingling; Wang, Caiyun; Zhang, Yanxia; Liu, Yujun; Ma, Chao] Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Natl Engn Lab Tree Breeding, Beijing 100083, Peoples R China.
   [Zhou, Xiaojing] Beijing Ctr Phys & Chem Anal, Beijing 100094, Peoples R China.
C3 Beijing Forestry University; Beijing Academy of Science & Technology
RP Liu, YJ (corresponding author), Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Natl Engn Lab Tree Breeding, Beijing 100083, Peoples R China.
EM yjliubio@163.com; machaothu@yahoo.com.cn
RI Zhou, Xiaojing/LQL-1430-2024; Ma, Chao/AAG-2939-2021; Wang,
   Caiyun/JWO-4111-2024; Liu, Yujun/H-3661-2015
OI Liu, Yujun/0000-0001-6588-3359
FU Fundamental Research Funds for the Central Universities, China
   [YX2012-02]; Ph.D. Programs Foundation of Ministry of Education of China
   [20120014110006]
FX The study was financially supported by the Fundamental Research Funds
   for the Central Universities, China (YX2012-02) and the Ph.D. Programs
   Foundation of Ministry of Education of China (20120014110006).
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NR 28
TC 30
Z9 32
U1 3
U2 60
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6857
EI 1573-5044
J9 PLANT CELL TISS ORG
JI Plant Cell Tissue Organ Cult.
PD SEP
PY 2013
VL 114
IS 3
BP 295
EP 303
DI 10.1007/s11240-013-0325-z
PG 9
WC Biotechnology & Applied Microbiology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Plant Sciences
GA 204RK
UT WOS:000323385900001
DA 2026-05-27
ER

PT J
AU Rodin, IA
   Stavrianidi, AN
   Braun, AV
   Shpigun, OA
   Popik, MV
AF Rodin, I. A.
   Stavrianidi, A. N.
   Braun, A. V.
   Shpigun, O. A.
   Popik, M. V.
TI Simultaneous determination of salidroside, rosavin, and rosarin in
   extracts from Rhodiola rosea by high performance liquid
   chromatography with tandem mass spectrometry detection
SO JOURNAL OF ANALYTICAL CHEMISTRY
LA English
DT Article
DE high-performance liquid chromatography/mass spectrometry; electrospray
   ionization; extraction; plant materials; Rhodiola rosea; salidroside;
   rosavin; rosarin
ID RAT PLASMA; IONIZATION; SEPARATION; L.
AB An approach is developed for the simultaneous determination of salidroside, rosarin, and rosavin in extracts from plant based on liquid chromatography/mass spectrometry; the detection limits of the method are 2, 4, and 6 ng/mL for salidroside, rosavin, and rosarin, respectively. The method was validated using real extracts from Rhodiola rosea rhizome. The analysis of extracts was accomplished by reversed-phase chromatography with a SB-C18 stationary phase. The analytes were detected by tandem mass spectrometry with electrospray ionization in the multiple reaction monitoring mode for negative ions.
C1 [Rodin, I. A.; Stavrianidi, A. N.; Braun, A. V.; Shpigun, O. A.; Popik, M. V.] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia.
C3 Lomonosov Moscow State University
RP Rodin, IA (corresponding author), Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia.
EM rodin@analyt.chem.msu.ru
RI Stavrianidi, Andrey/P-1736-2017; Rodin, Igor A/M-3359-2016
OI Stavrianidi, Andrey/0000-0003-2848-6535; Rodin, Igor
   A/0000-0002-0588-6870
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NR 10
TC 17
Z9 19
U1 0
U2 67
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 1061-9348
J9 J ANAL CHEM+
JI J. Anal. Chem.
PD DEC
PY 2012
VL 67
IS 13
BP 1026
EP 1030
DI 10.1134/S1061934812130096
PG 5
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 032XR
UT WOS:000310754400009
DA 2026-05-27
ER

PT J
AU Liu, B
   Wei, HL
   Lan, M
   Jia, N
   Liu, JM
   Zhang, M
AF Liu, Bing
   Wei, Huali
   Lan, Ming
   Jia, Na
   Liu, Junmeng
   Zhang, Meng
TI MicroRNA-21 mediates the protective effects of salidroside against
   hypoxia/reoxygenation-induced myocardial oxidative stress and
   inflammatory response
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE microRNA-21; salidroside; myocardial ischemia-reperfusion injury;
   oxidative stress; inflammation
ID ISCHEMIA-REPERFUSION INJURY; ISCHEMIA/REPERFUSION INJURY; IN-VITRO;
   RATS; MECHANISMS; PATHWAY; APOPTOSIS; PROTEIN; MIR-21; MODEL
AB Myocardial ischemia-reperfusion (I/R) injury is the oxidative stress and inflammatory response that occurs when a tissue is reperfused following a prolonged period of ischemic injury. Growing evidence has demonstrated that microRNAs (miRs) are essential in the development of myocardial I/R injury. Salidroside, a phenylpropanoid glycoside isolated from a traditional Chinese medicinal plant, Rhodiola rosea, possesses multiple pharmacological functions and protects against myocardial I/R injury in vitro and in vivo. However, the role of miRs in the cardioprotective effects of salidroside against myocardial I/R injury has not been studied, to the best of our knowledge. In the present study, the role of miR21 in the underlying mechanism of salidroside-induced protection against oxidative stress and inflammatory injuries in hypoxia/reoxygenation (H/R)-treated H9c2 cardiomyocytes was determined. The cell viability was assessed with an MTT assay. Lactate dehydrogenase (LDH) release, caspase-3 activity, malondialdehyde (MDA) level, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined by commercial kits. Cell apoptosis was measured by flow cytometry. Intracellular reactive oxygen species (ROS) generation was monitored by DCFH-DA. The miR-21 level was quantified by reverse transcription-quantitative (RT-q)PCR. The interleukin (IL)-6, IL-1 beta and tumor necrosis factor (TNF)-alpha levels were measured by RT-qPCR and ELISA. The results showed that salidroside pretreatment significantly increased cell viability and decreased the release of LDH, accompanied by an increase in miR-21 expression in H/R-treated H9c2 cells and a miR-21 inhibitor reversed these effects. In addition, the miR-21 inhibitor also abrogated the inhibition of salidroside on H/R-induced increases in apoptosis and caspase-3 activity in H9c2 cells. Salidroside mitigated H/R-induced oxidative stress as illustrated by the downregulation of ROS generation and MDA level and increased the activities of the antioxidant enzymes, SOD and GSH-Px, all of which were abrogated in cells transfected with the miR-21 inhibitor. Salidroside induced a decrease in the expression and levels of the pro-inflammatory cytokines, IL-6, IL-1 beta and TNF-alpha, which were prevented by the miR-21 inhibitor. Together, these results provide evidence of the beneficial effects of salidroside against myocardial I/R injury by reducing myocardial oxidative stress and inflammation which are enhanced by increasing miR-21 expression.
C1 [Liu, Bing; Lan, Ming; Jia, Na; Liu, Junmeng] Beiing Hosp, Dept Cardiol, Natl Ctr Gerontol China, Beijing 100730, Peoples R China.
   [Wei, Huali] Emergency Gen Hosp, Dept Gynecol & Obstet, Beijing 100028, Peoples R China.
   [Zhang, Meng] Aerosp Ctr Hosp, Dept Cardiol, 15 Yuquan Rd, Beijing 100049, Peoples R China.
C3 Aerospace Center Hospital
RP Zhang, M (corresponding author), Aerosp Ctr Hosp, Dept Cardiol, 15 Yuquan Rd, Beijing 100049, Peoples R China.
EM zhangm05022@qq.com
FU China Aerospace Science and Technology Group Corporation Medical and
   Health Research Project [2017-LCYL-003]
FX The present study was funded by the China Aerospace Science and
   Technology Group Corporation Medical and Health Research Project (grant
   no. 2017-LCYL-003).
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NR 49
TC 33
Z9 41
U1 0
U2 29
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2020
VL 19
IS 3
BP 1655
EP 1664
DI 10.3892/etm.2020.8421
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KU5CC
UT WOS:000519726400007
PM 32104217
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, YX
   Wang, Q
   Liu, B
   You, MY
   Jin, T
AF Wu, Yu-Xue
   Wang, Qiang
   Liu, Ben
   You, Men-Yun
   Jin, Ting
TI Supercritical Carbon Dioxide Extraction of Salidroside from
   Rhodiola rosea L var. rosea Root
SO JOURNAL OF THE CHINESE CHEMICAL SOCIETY
LA English
DT Article
DE Supercritical carbon dioxide extraction; Salidroside; Rhodiola rosea L
   var. rosea.
ID PHENOLIC-COMPOUNDS; SACHALINENSIS; PURIFICATION
AB Salidroside from the root of Rhodiola rosea L var. rosea was extracted by supercritical carbon dioxide with and without methanol as modifier. Three parameters, i.e. temperature, pressure and different concentrations of methanol were optimized. Salidroside determinations were carried out using high-performance liquid chromatography (HPLC) with UV-Vis detector. An experimental design of response surface methodology (RSM) was used to map the effect of pressure (at 200, 300 and 400 bar), temperature (at 50, 60 and 70 degrees C) and percentage of methanol modifier (at 80, 90 and 100%) on the extraction yield of the active compound and to determine the optimal conditions for the extraction of salidroside from the root of plant. The results showed that supercritical carbon dioxide failed to extract salidroside from the plant material without a methanol as modifier. The yield obtained after 1.5 h extraction with the rate of modifier 0.4 mL/min and 300 bar, 70 degrees C, and 80 percent of methanol modifier condition was the highest (17.15 mg/g). The optimum conditions were 70 degrees C, 295.49 bar and 80 percent of methanol as modifier with the yield of 16.17 mg/g. In addition, the yield obtained with supercritical fluid extraction (SFE) was compared with the Soxhlet extraction, whose yield was 8.64 mg/g.
C1 [Wu, Yu-Xue; Wang, Qiang; Liu, Ben; You, Men-Yun; Jin, Ting] Zhejiang Univ, Coll Biochem Engn, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Wang, Q (corresponding author), Zhejiang Univ, Coll Biochem Engn, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China.
EM wangqiangsky@263.net
FU National Nature Science Foundation of China [30470330, 30770334]
FX This work was supported by the National Nature Science Foundation of
   China (Grant Nos. 30470330; 30770334).
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NR 12
TC 11
Z9 11
U1 0
U2 30
PU CHINESE CHEMICAL SOC
PI TAIPEI
PA PO BOX 1-18, NANKANG, TAIPEI 115, TAIWAN
SN 0009-4536
J9 J CHIN CHEM SOC-TAIP
JI J. Chin. Chem. Soc.
PD APR
PY 2011
VL 58
IS 2
BP 222
EP 227
DI 10.1002/jccs.201190080
PG 6
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 766KL
UT WOS:000290780900013
OA Bronze
DA 2026-05-27
ER

PT J
AU Jin, T
   Lian, WS
   Zhang, XJ
   Wang, SQ
   Xu, MJ
   Sherchan, A
   Li, MQ
AF Jin, Tao
   Lian, Weishuai
   Zhang, Xiaojun
   Wang, Shuqing
   Xu, Minjie
   Sherchan, Amir
   Li, Maoquan
TI An in vitro study on probable inhibition of
   cerebrovascular disease by salidroside as a potent small molecule
   against induction of protein amyloid fibrils and cytotoxicity
SO ARABIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Amyloid b; Salidroside; Cerebrovascular endothelial cell
ID INDUCED OXIDATIVE STRESS; ENDOTHELIAL-CELLS; FLUORESCENT-PROBE;
   BETA-PEPTIDE; PC12 CELLS; AGGREGATION; DYSFUNCTION; APOPTOSIS; INJURY
AB Protein aggregation and associated amyloid formation is linked with several harmful human pathophysiologies including Alzheimer's, Parkinson's, and cerebrovascular diseases. A potential approach for modulating and exploring amyloid fibrillization is the control of protein self-assembly. Herein, anti-aggregation effects of salidroside, its influence on the kinetics of amyloid fibrillization of Ab1-42 peptide and its cytotoxicity against cerebrovascular endothelial cells (bEnd.3) were assessed by using a wide range of spectroscopic and cellular techniques. The present outcome of Thioflavin T (ThT) and 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence, Congo red (CR), and circular dichroism (CD) analyses indicated that salidroside potentially inhibits protein fibril formation. The cellular studies inferred that salidroside protects bEnd.3 cells against Ab1-42 oligomers-triggered cytotoxicity through modulation of oxidative stress [reactive oxygen species (ROS), superoxide dismutase (SOD) and catalase (CAT) activities] and apoptosis (caspase-3 activ-ity). Therefore, the data signifies the role of salidroside as a promising small molecule in inhibiting Ab1-42 aggregation and associated cerebrovascular endothelial cell toxicity. Hence, salidroside can serve as a potential inhibitor in the therapeutic advancement to combat cerebrovascular diseases.(c) 2023 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Jin, Tao; Lian, Weishuai; Zhang, Xiaojun; Wang, Shuqing; Xu, Minjie; Sherchan, Amir; Li, Maoquan] Tongji Univ, Dept Intervent & Vasc Surg, Tenth Peoples Hosp, Shanghai 200072, Peoples R China.
   [Li, Maoquan] 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
C3 Tongji University
RP Li, MQ (corresponding author), 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
EM cjr.limaoquan@vip.163.com
RI Jin, Tao/LEN-0687-2024
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NR 60
TC 3
Z9 4
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1878-5352
EI 1878-5379
J9 ARAB J CHEM
JI Arab. J. Chem.
PD APR
PY 2023
VL 16
IS 4
AR 104548
DI 10.1016/j.arabjc.2023.104548
EA FEB 2023
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 9Q6IG
UT WOS:000945065000001
OA gold
DA 2026-05-27
ER

PT J
AU Ma, CY
   Hu, LM
   Tao, GJ
   Lv, WP
   Wang, HX
AF Ma, Chaoyang
   Hu, Liming
   Tao, Guanjun
   Lv, Wenping
   Wang, Hongxin
TI An UPLC-MS-based metabolomics investigation on the anti-fatigue effect
   of salidroside in
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE UPLC-MS/MS; Metabolomics; Salidroside; Anti-fatigue; Biomarkers
ID CHROMATOGRAPHY-MASS-SPECTROMETRY; ACTIVATED PROTEIN-KINASE;
   RHODIOLA-ROSEA; NATURAL-PRODUCTS; ADSORPTION CHROMATOGRAPHY; SYSTEMS
   BIOLOGY; GLUCOSE-UPTAKE; GLUCURONIDATION; PRESSURE; CORTISOL
AB An ultra-performance liquid chromatography-quadrupole time-of-flight-based metabolomic approach was developed to study influence of salidroside, an anti-fatigue ingredient from Rhoiola rosea, on urinary metabolic profiling of rats to a single dose of 180 mg/kg per day. Unsupervised principal component analysis (PCA) and supervised orthogonal pre-projection to latent structures discriminate analysis (OPLS-DA) on metabolite profiling revealed obvious differentiation between the salidroside treated groups and controls in both positive and negative ion modes. Eleven urinary metabolites contributing to the differentiation were identified as anti-fatigue biomarkers: N-acetylserotonin, 2-Methoxyestrone 3-glucuronide, Taurine, Melatonin, Sorbitol, Geranyl diphosphate, Z-nucleotide, Cortisone, Dihydrocortisol, Sebacic acid, Pregnenolone sulfate. The physiological significance of these biomarkers is discussed. The work showed that metabolomics is a powerful tool in studying the anti-fatigue effects of natural compound salidroside on multiple targets in vivo. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ma, Chaoyang; Tao, Guanjun; Lv, Wenping; Wang, Hongxin] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China.
   [Hu, Liming] Air Force Logist Coll, Xuzhou 221006, Jiangshu, Peoples R China.
C3 Jiangnan University
RP Wang, HX (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Peoples R China.
EM wanghongxin2009@hotmail.com
FU National Twelfth-Five Year Research Program of China [2012BAD33B05];
   Fundamental Research Funds for the Central Universities [JUSRP211A32]
FX We gratefully acknowledge the financial support of National Twelfth-Five
   Year Research Program of China (No. 2012BAD33B05) and the Fundamental
   Research Funds for the Central Universities (JUSRP211A32).
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NR 49
TC 54
Z9 61
U1 0
U2 123
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD FEB 25
PY 2015
VL 105
BP 84
EP 90
DI 10.1016/j.jpba.2014.11.036
PG 7
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA CA6YU
UT WOS:000349064600011
PM 25543286
DA 2026-05-27
ER

PT J
AU Guo, N
   Hu, ZW
   Fan, XX
   Zheng, J
   Zhang, DH
   Xu, T
   Yu, T
   Wang, Y
   Li, HY
AF Guo, Na
   Hu, Zhiwei
   Fan, Xiaoxu
   Zheng, Jian
   Zhang, Dehui
   Xu, Tao
   Yu, Tao
   Wang, Yang
   Li, Haiying
TI Simultaneous Determination of Salidroside and Its Aglycone Metabolite
   p-Tyrosol in Rat Plasma by Liquid Chromatography-Tandem Mass
   Spectrometry
SO MOLECULES
LA English
DT Article
DE salidroside; p-tyrosol; metabolite; LC-MS/MS; pharmacokinetics
ID SMALL-INTESTINE; INDUCED INJURY; GLYCOSIDES; BIOAVAILABILITY;
   EXTRACTION; FLAVONOIDS; BIOMARKERS; INJECTION; PROTECTS; FORMS
AB Salidroside and its aglycone p-tyrosol are two major phenols in the genus Rhodiola and have been confirmed to possess various pharmacological properties. In our present study, p-tyrosol was identified as the deglycosylation metabolite of salidroside after intravenous (i.v.) administration to rats at a dose of 50 mg/kg, but was not detectable after intragastric gavage (i.g.) administration through HPLC-photodiode array detection (PDA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Next, an accurate and precise LC-MS/MS method was developed to quantitatively determine salidroside and p-tyrosol in rat plasma samples. Samples were analyzed by LC-MS/MS on a reverse-phase xTerra MS C18 column which was equilibrated and eluted with an isocratic mixture of acetonitrile-water (1: 9, v/v) at a flow rate of 0.3 mL/min. The analytes were monitored by multiple reaction monitoring (MRM) under the negative electrospray ionization mode. The precursor/product transitions (m/z) were 299.0 -> 118.8 for salidroside, 137.0 -> 118.9 for p-tyrosol and 150.1 -> 106.9 for the internal standard (IS), paracetamol, respectively. The calibration curve was linear over the concentration ranges of 50-2,000 ng/mL for salidroside and 20-200 ng/mL for p-tyrosol. The inter- and intra-day accuracy and precision were within +/- 15%. The method has been successfully applied to the pharmacokinetic study and the oral bioavailability was calculated.
C1 [Guo, Na; Hu, Zhiwei; Zheng, Jian; Zhang, Dehui; Xu, Tao; Yu, Tao; Wang, Yang] NE Forestry Univ, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Minist Educ, Alkali Soil Nat Environm Sci Ctr, Harbin 150040, Peoples R China.
   [Fan, Xiaoxu; Li, Haiying] Heilongjiang Univ, Coll Life Sci, Harbin 150080, Peoples R China.
C3 Northeast Forestry University - China; Heilongjiang University
RP Wang, Y (corresponding author), NE Forestry Univ, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Minist Educ, Alkali Soil Nat Environm Sci Ctr, Harbin 150040, Peoples R China.
EM guona0329@126.com; huzhiwei.haerbin@yahoo.com.cn; ywang@nefu.edu.cn;
   lvzh3000@sina.com
RI Zhang, Dehui/C-3749-2014
FU Zhejiang Provincial Natural Science Foundation of China [Z2100435]
FX This research is financially supported by Zhejiang Provincial Natural
   Science Foundation of China (Z2100435).
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NR 34
TC 48
Z9 58
U1 0
U2 65
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2012
VL 17
IS 4
BP 4733
EP 4754
DI 10.3390/molecules17044733
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 932SD
UT WOS:000303309900080
PM 22525439
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fan, YC
   Guo, L
   Wei, JH
   Chen, JZ
   Sun, H
   Guo, T
AF Fan, Yuchen
   Guo, Li
   Wei, Jiahong
   Chen, Junzhao
   Sun, Hao
   Guo, Tao
TI Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix
   Expression and Mouse Intraocular Pressure
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE salidroside; TGF-beta 2; trabecular meshwork; extracellular matrix;
   glaucoma; intraocular pressure
ID INDUCED OCULAR HYPERTENSION; ACUTE LUNG INJURY; NF-KAPPA-B;
   AQUEOUS-HUMOR; GLAUCOMATOUS EYES; RHODIOLA-ROSEA; ACTIVATION; GREMLIN;
   MICE
AB PURPOSE. Excessive accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) reduces aqueous humor outflow, which likely contributes to elevation of IOP in primary open-angle glaucoma (POAG). Salidroside, a phenolic glycoside isolated from Rhodiola rosea is reported to prevent profibrotic responses by inhibiting Smad signaling pathway activated by TGF-beta in liver, lung, and kidney tissues. We tested if salidroside can (1) inhibit TGF-beta 2-induced ECM expression in cultured human TM cells, and (2) lower TGF-beta 2-induced ocular hypertension in the mouse.
   METHODS. Cultured human TM cells stimulated with 5 ng/mL TGF-beta 2 for 48 hours were treated with salidroside for 24 hours. The expressions of fibronectin (FN), collagen type IV (COL-IV), and laminin (LN) were evaluated by quantitative PCR, Western blot, and immunocytochemistry. BALB/cJ mice were injected intravitreally with an adenoviral vector encoding a bioactive mutant of TGF-beta 2 (Ad. hTGF-beta 2(226/228)) in one eye to induce ocular hypertension, with the uninjected contralateral or Ad. Empty-injected eyes serving as controls. Mice were treated with a daily intraperitoneal injection of 40 mg/kg salidroside. Conscious mouse IOP values were measured using a TonoLab rebound tonometer.
   RESULTS. In cultured human TM cells, treatment with TGF-beta 2 increased expressions of FN, COL-IV, and LN, as assessed by quantitative PCR, Western blotting, and immunocytochemistry, all of which were significantly and completely ameliorated by 30 mu M salidroside. Daily intraperitoneal injections of salidroside (40 mg/kg), starting either at day 0 (same day as Ad. hTGF-beta 2(226/228) injection) or at day 14, significantly lowered TGF-beta 2-induced ocular hypertension in the mouse. In contrast, salidroside did not affect IOP of control eyes.
   CONCLUSIONS. These results demonstrated that salidroside is capable of minimizing TGF-beta 2-induced ECM expression in cultured human TM cells. It also reduced TGF-beta 2-induced ocular hypertension in the mouse. These findings indicate that this phenolic glycoside may be useful as a novel treatment for POAG.
C1 [Fan, Yuchen; Chen, Junzhao; Sun, Hao; Guo, Tao] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Ophthalmol, Sch Med, 639 Zhizaoju Rd, Shanghai, Peoples R China.
   [Fan, Yuchen; Chen, Junzhao; Sun, Hao; Guo, Tao] Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai, Peoples R China.
   [Fan, Yuchen; Wei, Jiahong] Bengbu Med Coll, Bengbu, Anhui, Peoples R China.
   [Guo, Li] Anhui Med Univ, Luan Affiliated Hosp, Dept Ophthalmol, Luan, Anhui, Peoples R China.
C3 Shanghai Jiao Tong University; Bengbu Medical University; Anhui Medical
   University
RP Guo, T (corresponding author), Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Ophthalmol, Sch Med, 639 Zhizaoju Rd, Shanghai, Peoples R China.
EM guotao9@hotmail.com
RI ; Sun, Hao/AAX-1653-2020
OI guo, tao/0000-0001-6808-064X; 
FU National Natural Science Foundations of China [31500835]; Science and
   Technology Commission of Shanghai [19411961500, 15411970000,
   17DZ2260100]
FX Supported by the National Natural Science Foundations of China
   (31500835) and The Science and Technology Commission of Shanghai (grant
   nos. 19411961500, 15411970000, and 17DZ2260100).
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NR 35
TC 22
Z9 24
U1 0
U2 12
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAY
PY 2019
VL 60
IS 6
BP 2072
EP 2082
DI 10.1167/iovs.19-26585
PG 11
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA HZ6RS
UT WOS:000468980600030
PM 31091314
OA gold
DA 2026-05-27
ER

PT J
AU Li, JL
   Xi, JQ
AF Li, Jia-lu
   Xi, Ju-qun
TI Combination of Apatinib and Salidroside Inhibits the Progression of
   Non-Small Cell Lung Cancer through MAPK/ERK/VEGF Signaling Axis
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE apatinib; salidroside; non-small cell lung cancer; MAPK/ERK/VEGF
   signaling axis; synergistic effect
ID PATHWAY; PROLIFERATION; APOPTOSIS; MIGRATION; GROWTH; DEATH
AB Background: Lung cancer is the leading cause of cancer-related deaths, where non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. The potential of apatinib, a small-molecule anti-angiogenic drug, and salidroside, the Chinese herbal extract, as anti-tumor agents has been recognized. Therefore, this study aims to investigate the synergistic effects of apatinib and salidroside on NSCLC and provide insights into this combination to evaluate their combined potential in treating NSCLC. Methods: 3-(4,5-dimethylthiazol)-2,5-diphenyl-tetrazolium bromide (MTT) assay was employed to determine the inhibitory effects of different concentrations of apatinib, salidroside and their combination on NSCLC cell proliferation. The levels of reactive oxygen species (ROS) in NSCLC cells were assessed in treated cells. Furthermore, flow cytometry, wound healing assay, and tube formation assay were used to determine the apoptosis rate, migration ability, and angiogenesis of cells, respectively. Additionally, western blot analysis was utilized to evaluate the levels of apoptosis-related proteins and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)/vascular endothelial growth factor (VEGF) axis-related proteins. Results: Compared to using either apatinib or salidroside for treatment alone, apatinib in combination with salidroside (Sal) significantly inhibited NSCLC cell proliferation, migration, and tube formation (p < 0.01). Meanwhile, this combination ((apatinib) Apa+Sal) induced ROS production and promoted apoptosis by up-regulating Bcl-2 associated X (Bax) expression and down-regulating B cell lymphoma-2 (Bcl-2) expression (p < 0.01). Western blot analysis revealed a substantial increase in the phosphor (p)-p38 expression, and decreased p-ERK, VEGF, and VEGF receptor (VEGFR) levels in the combined treated group compared to the single treatment group (p < 0.05). Combined treatment coupled with MAPK/ERK inhibitor (SB203580) or activator (anisomycin) significantly enhanced or decreased the inhibitory effect of apatinib and salidroside on human umbilical vein endothelial cells (HUVEC) tube formation, respectively. Conclusion: Apatinib in combination with salidroside exerts a synergistic anticancer effect in NSCLC by down-regulating the MAPK/ERK/VEGF signaling axis, which suggests the potential of this combined therapy in treating NSCLC.
C1 [Li, Jia-lu; Xi, Ju-qun] Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Jiangsu, Peoples R China.
   [Xi, Ju-qun] Jiangsu Key Lab Integrated Tradit Chinese & Wester, Yangzhou 225009, Jiangsu, Peoples R China.
C3 Yangzhou University
RP Xi, JQ (corresponding author), Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Jiangsu, Peoples R China.; Xi, JQ (corresponding author), Jiangsu Key Lab Integrated Tradit Chinese & Wester, Yangzhou 225009, Jiangsu, Peoples R China.
EM xijqyzu@163.com
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NR 40
TC 0
Z9 0
U1 0
U2 9
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD APR
PY 2024
VL 38
IS 4
BP 3111
EP 3121
DI 10.23812/j.biol.regul.homeost.agents.20243804.244
PG 11
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA NW2W2
UT WOS:001203436700001
OA hybrid
DA 2026-05-27
ER

PT J
AU Sun, JF
   Zhu, LL
   Duan, LP
   Li, FR
   Guo, S
   Bian, JL
   Yang, L
AF Sun, Jingfang
   Zhu, Lingling
   Duan, Liuping
   Li, Furong
   Guo, Shuai
   Bian, Jinlei
   Yang, Lin
TI Metabolic engineering of Saccharomyces cerevisiae for de
   novo biosynthesis of hydroxytyrosol and salidroside
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
DE hydroxytyrosol; salidroside; tyrosol; phenylethanol compounds;
   <italic>Saccharomyces cerevisiae</italic>
ID FEEDBACK INHIBITION; YEAST; PATHWAY; ACID
AB Hydroxytyrosol and salidroside are phenylethanol compounds with significant industrial applications but limited availability due to low-yield natural extraction and complex chemical synthesis. In this study, Saccharomyces cerevisiae was engineered to achieve efficient de novo biosynthesis of these compounds. A tyrosol-producing strain (ZYT1) was optimized to produce 571.8 mg/L tyrosol, which served as the yeast chassis cell for hydroxytyrosol synthesis. By integrating PaHpaB and EcHpaC, strain ZYHT1 produced 304.4 mg/L hydroxytyrosol in shake-flask fermentation, which increased to 677.6 mg/L in a 15 L bioreactor after auxotrophic repair. For salidroside production, glycosyltransferase RrU8GT33 was introduced into ZYT1, yielding strain ZYSAL1 with 48.4 mg/L salidroside. Enhancing UDP-glucose supply using truncated sucrose synthase (tGuSUS1) led to strain ZYSAL9+3, which achieved 1,021.0 mg/L in shake flasks and 18.9 g/L in fed-batch fermentation. This work demonstrates the scalable production of hydroxytyrosol and salidroside in yeast, providing a basis for industrial applications and advancing synthetic biology approaches for natural product biosynthesis.IMPORTANCEHydroxytyrosol and salidroside are valuable natural compounds with strong antioxidant, anti-inflammatory, and neuroprotective properties, widely used in pharmaceuticals, cosmetics, and health supplements. However, traditional extraction from plants is inefficient, and chemical synthesis is costly and environmentally unfriendly. In this study, we engineered Saccharomyces cerevisiae, a common yeast, to efficiently produce these compounds from simple carbon sources such as glucose and sucrose. By optimizing key biosynthetic pathways, improving cofactor supply, and enhancing sucrose metabolism, we achieved high production levels suitable for industrial applications. Our work provides a sustainable and scalable microbial platform for producing hydroxytyrosol and salidroside, reducing reliance on plant extraction and chemical synthesis. This research advances the field of microbial biotechnology by demonstrating how engineered yeast can serve as a green factory for valuable bioactive compounds, opening new possibilities for large-scale production and commercial use.
C1 [Sun, Jingfang; Zhu, Lingling; Duan, Liuping; Li, Furong; Guo, Shuai; Yang, Lin] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing, Peoples R China.
   [Sun, Jingfang; Bian, Jinlei] China Pharmaceut Univ, Sch Pharm, Nanjing, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Guo, S; Yang, L (corresponding author), China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing, Peoples R China.; Bian, JL (corresponding author), China Pharmaceut Univ, Sch Pharm, Nanjing, Peoples R China.
EM shuaiguo@cpu.edu.cn; bianjl@cpu.edu.cn; lin_yang@cpu.edu.cn
RI ; Guo, Shuai/LJK-6385-2024; Zhu, Linhling/JXL-9949-2024
OI Bian, Jinlei/0000-0003-4552-1195; Yang, Lin/0000-0003-1547-8990
FU National Key Research and Development Program of China [2019YFA0904900];
   National Key R&D Program of China
FX This work was supported by the National Key R&D Program of China
   (2019YFA0904900).
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NR 35
TC 8
Z9 8
U1 24
U2 40
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD AUG 20
PY 2025
VL 91
IS 8
DI 10.1128/aem.00712-25
EA JUL 2025
PG 16
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA 6JK8H
UT WOS:001529552500001
PM 40668011
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, XX
   Zhang, ZD
   Wang, XP
AF Wu, Xiaoxiong
   Zhang, Zhendong
   Wang, Xiaoping
TI Research progress on anti-cancer mechanism of salidroside regulating
   miRNA-mRNA signaling axis
SO ONCOLOGIE
LA English
DT Review
DE tumor; salidroside; microRNA; mRNA; signaling axis
ID LUNG-CANCER CELLS; BREAST-CANCER; PROLIFERATION; MIGRATION; INVASION;
   CONTRIBUTES; TRANSITION; APOPTOSIS; PATHWAY; TARGETS
AB MiRNA (MicroRNA) can target and regulate mRNA, thereby influencing the biological processes of tumors. The extract of Tibetan medicine Rhodiola demonstrates anti-tumor effects by targeting and regulating cancer-related signaling molecules and pathways. This review aims to pave the way for integrating salidroside into clinical practice, fully leverage its multi-effective and multi-targeted biological effects, and innovate approaches to tumor prevention and management, thus enhancing cancer prognosis. We initially delve into the occurrence and mechanism of action of miRNA, as well as the anti-tumor mechanism of the miRNA-mRNA signaling axis. Additionally, it was described that salidroside can hinder cancer cell proliferation by inducing autophagy and apoptosis, inhibiting cell metastasis and invasion, and modulating the tumor microenvironment and cell cycle. Moreover, examples from lung cancer, gastric cancer, and nasopharyngeal carcinoma confirm that salidroside regulates the onset and progression of tumors through the miRNA-mRNA signaling axis. This groundbreaking discovery carries significant implications for cancer diagnosis and treatment, offering a novel pathway for therapeutic intervention.
C1 [Wu, Xiaoxiong; Zhang, Zhendong; Wang, Xiaoping] Xizang Minzu Univ, Sch Med, Xianyang 712082, Shaanxi, Peoples R China.
C3 Xizang Minzu University
RP Wang, XP (corresponding author), Xizang Minzu Univ, Sch Med, Xianyang 712082, Shaanxi, Peoples R China.
EM xpwang@xzmu.edu.cn
RI Wu, Xiao-Xiong/JXM-2784-2024
OI Wu, Xiao-Xiong/0009-0008-0073-5310
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NR 77
TC 0
Z9 0
U1 3
U2 20
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1292-3818
EI 1765-2839
J9 ONCOLOGIE
JI Oncologie
PD AUG 2
PY 2024
VL 26
IS 4
BP 525
EP 534
DI 10.1515/oncologie-2024-0166
EA JUL 2024
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA A5Z1A
UT WOS:001269911000001
OA gold
DA 2026-05-27
ER

PT J
AU Kwon, HJ
   Kim, YS
   Hwang, JW
   Kim, CY
   Lee, SH
   Moon, SH
   Jeon, BT
   Park, PJ
AF Kwon, Hyuck-Ju
   Kim, Yon-Suk
   Hwang, Jin-Woo
   Kim, Chul Young
   Lee, Sang-Hoon
   Moon, Sang-Ho
   Jeon, Byong-Tae
   Park, Pyo-Jam
TI Isolation and identification of an anticancer compound from the bark of
   Acer tegmentosum Maxim
SO PROCESS BIOCHEMISTRY
LA English
DT Article
DE Acer tegmentosum Maxim; Anticancer; Salidroside; HepG2 cells
ID CANCER-CHEMOTHERAPY; NATURAL-PRODUCTS; PC12 CELLS; SALIDROSIDE;
   APOPTOSIS; EXTRACT; PROTEIN; EXPRESSION; BCL-2; DNA
AB In this study, we investigated the anticancer activity of a newly isolated compound from Acer tegmentosum Maxim (ATM) in HepG2 cells. This compound was isolated by reverse-phase high-performance liquid chromatography (RP-HPLC) in a butanol-soluble fraction, which was shown to have the strongest anticancer activity. The isolated compound was identified as salidroside using multiple nuclear magnetic resonance (NMR) techniques, including H-1, C-13, correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlation (HMBC), as well as electrospray ionization mass spectroscopy (ESI/MS). The activity of salidroside was evaluated in HepG2 cells by analyzing cell proliferation, cell cycle distribution, Hoechst 33342 staining, and Western blots of apoptotic regulatory proteins. The results show that salidroside, an anticancer compound from ATM, exhibits strong apoptotic activity in HepG2 cells. Therefore, ATM extracts could be used as chemotherapeutic agent to induce apoptosis in hepatoblastoma cells. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Kwon, Hyuck-Ju; Kim, Yon-Suk; Hwang, Jin-Woo; Park, Pyo-Jam] Konkuk Univ, Dept Biotechnol, Chungju 380701, South Korea.
   [Kim, Yon-Suk; Hwang, Jin-Woo; Park, Pyo-Jam] Konkuk Univ, Dept Appl Life Sci, Chungju 380701, South Korea.
   [Kim, Chul Young] Hanyang Univ, Coll Pharm, Anson 426791, South Korea.
   [Lee, Sang-Hoon] Korea Food Res Inst, Songnam 463746, South Korea.
   [Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam] Konkuk Univ, Korea Nokyong Res Ctr, Chungju 380701, South Korea.
C3 Konkuk University; Konkuk University; Hanyang University; Korea Food
   Research Institute (KFRI); Konkuk University
RP Park, PJ (corresponding author), Konkuk Univ, Dept Biotechnol, Chungju 380701, South Korea.
EM parkpj@kku.ac.kr
FU Konkuk University
FX This work was supported by Konkuk University.
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NR 39
TC 5
Z9 6
U1 0
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-5113
EI 1873-3298
J9 PROCESS BIOCHEM
JI Process Biochem.
PD JUN
PY 2014
VL 49
IS 6
BP 1032
EP 1039
DI 10.1016/j.procbio.2014.03.002
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering
GA AJ4PQ
UT WOS:000337658700015
DA 2026-05-27
ER

PT J
AU Grech-Baran, M
   Syklowska-Baranek, K
   Pietrosiuk, A
AF Grech-Baran, Marta
   Syklowska-Baranek, Katarzyna
   Pietrosiuk, Agnieszka
TI Biotechnological approaches to enhance salidroside, rosin and its
   derivatives production in selected Rhodiola spp. in vitro
   cultures
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Article
DE Biotransformation; In vitro cultures; Rhodiola spp.; Rosin derivatives;
   Salidroside
ID BIOLOGICALLY-ACTIVE COMPOUNDS; CHINESE NATURAL MEDICINES;
   CELL-SUSPENSION CULTURES; ROSEA L.; BIOACTIVE CONSTITUENTS;
   CHEMICAL-STRUCTURES; KIRILOWII EXTRACTS; PHENOLIC-COMPOUNDS;
   DOUBLE-BLIND; SACHALINENSIS
AB Rhodiola (Crassulaceae) an arctic-alpine plant, is extensively used in traditional folk medicine in Asian and European countries. A number of investigations have demonstrated that Rhodiola preparations exhibit adaptogenic, neuroprotective, anti-tumour, cardioprotective, and anti-depressant effects. The main compounds responsible for these activities are believed to be salidroside, rosin and its derivatives which became the target of biotechnological investigations. This review summarizes the results of the diverse biotechnological approaches undertaken to enhance the production of salidroside, rosin and its derivatives in callus, cell suspension and organ in vitro cultures of selected Rhodiola species.
C1 [Grech-Baran, Marta; Syklowska-Baranek, Katarzyna; Pietrosiuk, Agnieszka] Med Univ Warsaw, Dept Pharmaceut Biol & Med Plant Biotechnol, Fac Pharm, PL-02097 Warsaw, Poland.
C3 Medical University of Warsaw
RP Grech-Baran, M (corresponding author), Med Univ Warsaw, Dept Pharmaceut Biol & Med Plant Biotechnol, Fac Pharm, Banacha 1 St, PL-02097 Warsaw, Poland.
EM mgrech@wum.edu.pl
RI Sykłowska-Baranek, Katarzyna/U-4650-2018; Pietrosiuk,
   Agnieszka/A-1320-2012
OI Sykłowska-Baranek, Katarzyna/0000-0002-9150-7872; Pietrosiuk,
   Agnieszka/0000-0001-7165-5336
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NR 130
TC 65
Z9 78
U1 3
U2 114
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1568-7767
EI 1572-980X
J9 PHYTOCHEM REV
JI Phytochem. Rev.
PD AUG
PY 2015
VL 14
IS 4
SI SI
BP 657
EP 674
DI 10.1007/s11101-014-9368-y
PG 18
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA CN4PG
UT WOS:000358411700007
PM 26213525
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Schwarz, NA
   Stratton, MT
   Colquhoun, RJ
   Manganti, AM
   Sherbourne, M
   Mourey, F
   White, CC
   Day, H
   Dusseault, MC
   Hudson, GM
   Vickery, CR
   Schachner, HC
   Kasprzyk, PG
   Weng, JK
AF Schwarz, Neil A.
   Stratton, Matthew T.
   Colquhoun, Ryan J.
   Manganti, Alexia M.
   Sherbourne, Margaux
   Mourey, Florian
   White, Caitlyn C.
   Day, Heather
   Dusseault, Micaela C.
   Hudson, Geoffrey M.
   Vickery, Christopher R.
   Schachner, Holly C.
   Kasprzyk, Philip G.
   Weng, Jing-Ke
TI Salidroside and exercise performance in healthy active young adults - an
   exploratory, randomized, double-blind, placebo-controlled study
SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
LA English
DT Article
DE Salidroside; rhodiola rosea; adaptogen; high-intensity interval
   exercise; oxygen consumption; golden root
ID RHODIOLA-ROSEA L.; OXIDATIVE STRESS; EXTRACT SHR-5; KINASE; PROTEIN;
   AMPK
AB BackgroundRhodiola rosea extract is purported to improve physical performance and support resilience to stress. Salidroside is considered to be one of the main constituents responsible for the ergogenic actions of R. rosea. However, R. rosea extract contains relatively little salidroside and cultivation of R. rosea is challenging as it is mainly found in high-altitude, cold regions. Additionally, the R. rosea plant is subject to conservation concerns because of its growing popularity. The purpose of this exploratory study was to evaluate the short-term effects of pure, biosynthetic salidroside supplementation on exercise performance, mood state, and markers of inflammation and muscle damage in healthy active young adults. MethodsFifty participants (30 M, 20F; 21 +/- 4 yrs; 173 +/- 8 cm; 74 +/- 13 kg) were randomly assigned to either salidroside (60 mg/day for 16 days) or placebo supplementation and underwent peak oxygen uptake (VO2 peak), intermittent time-to-exhaustion (TTE), and local muscular endurance assessments, along with mood state evaluations using the Profile of Mood States (POMS). Blood samples were analyzed for erythropoietin, myoglobin, creatine kinase-MM, and C-reactive protein. ResultsSalidroside supplementation enhanced overall percent predicted oxygen uptake during high-intensity intermittent exercise (p < 0.01). An increase in serum myoglobin was observed 24 hours following exercise in the placebo group (p = 0.02) compared with baseline whereas no statistically significant increase was observed for the salidroside group indicating reduced exercise-induced muscle damage. Placebo group experienced a decrease in number of intervals performed during the TTE test (p = 0.03), and a decrease in friendliness (p < 0.01) and an increase in fatigue-inertia (p < 0.01) as reported by POMS. The salidroside group exhibited stable mood states and maintained performance levels during the time-to-exhaustion test. ConclusionSalidroside supplementation may enhance oxygen utilization and mitigate exercise-induced muscle damage and fatigue, warranting further research on its long-term effects and potential as an adaptogen for active individuals.
C1 [Schwarz, Neil A.; Stratton, Matthew T.; Colquhoun, Ryan J.; Manganti, Alexia M.; White, Caitlyn C.; Day, Heather; Dusseault, Micaela C.; Hudson, Geoffrey M.] Univ S Alabama, Dept Hlth Kinesiol & Sport, Exercise & Nutr Res Grp ENRG, Mobile, AL 36688 USA.
   [Schwarz, Neil A.; Colquhoun, Ryan J.] Univ S Alabama, Frederick C Whiddon Coll Med, Dept Physiol & Cell Biol, Mobile, AL USA.
   [Sherbourne, Margaux; Mourey, Florian] Gnosis Lesaffre Lesaffre Grp, Dept Res & Applicat, Marcq En Baroeul, France.
   [Vickery, Christopher R.] Recombia Biosci Lesaffre, Bedford, MA USA.
   [Schachner, Holly C.; Kasprzyk, Philip G.; Weng, Jing-Ke] DoubleRainbow Biosci Inc, Cambridge, MA USA.
   [Weng, Jing-Ke] Northeastern Univ, Inst Plant Human Interface, Boston, MA 02120 USA.
   [Weng, Jing-Ke] Northeastern Univ, Dept Chem & Chem Biol, Dept Bioengn, Boston, MA USA.
   [Weng, Jing-Ke] Northeastern Univ, Dept Chem Engn, Boston, MA USA.
C3 University of South Alabama; University of South Alabama; Northeastern
   University; Northeastern University; Northeastern University
RP Schwarz, NA (corresponding author), Univ S Alabama, Dept Hlth Kinesiol & Sport, Exercise & Nutr Res Grp ENRG, Mobile, AL 36688 USA.
EM neilschwarz@southalabama.edu
RI White, Caitlyn/HMV-2307-2023; Weng, Jing-Ke/V-5934-2019; /J-1631-2014
FU Double Rainbow Biosciences, Inc (Lexington MA, USA); Double Rainbow
   Biosciences LLC
FX This study was financially supported by Double Rainbow Biosciences, Inc
   (Lexington MA, USA). Double Rainbow Biosciences LLC.
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TC 8
Z9 9
U1 2
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
EI 1550-2783
J9 J INT SOC SPORT NUTR
JI J. Int. Soc. Sport Nutr.
PD DEC 31
PY 2024
VL 21
IS 1
AR 2433744
DI 10.1080/15502783.2024.2433744
PG 28
WC Nutrition & Dietetics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Sport Sciences
GA N6O8W
UT WOS:001365519000001
PM 39601362
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, X
   Li, XB
   Jiang, JL
   Liu, ZN
   Qiao, B
   Li, FF
   Cheng, JS
   Sun, XC
   Yuan, YJ
   Qiao, JJ
   Zhao, GR
AF Liu, Xue
   Li, Xiao-Bo
   Jiang, Jianlan
   Liu, Zhen-Ning
   Qiao, Bin
   Li, Fei-Fei
   Cheng, Jing-Sheng
   Sun, Xiaocui
   Yuan, Ying-Jin
   Qiao, Jianjun
   Zhao, Guang-Rong
TI Convergent engineering of syntrophic Escherichia coli coculture
   for efficient production of glycosides
SO METABOLIC ENGINEERING
LA English
DT Article
DE Salidroside; Coculture; Co-culture; Consortium; Glycoside; Escherichia
   coli; Metabolic engineering; Synthetic biology
ID GLUCOSE-XYLOSE MIXTURE; PHOSPHOTRANSFERASE SYSTEM; MICROBIAL CONSORTIUM;
   BIOLOGICAL-ACTIVITY; NATURAL-PRODUCTS; PATHWAY; BIOSYNTHESIS; ACID;
   OPTIMIZATION; METABOLISM
AB Synthetic microbial coculture to express heterologous biosynthetic pathway for de novo production of medicinal ingredients is an emerging strategy for metabolic engineering and synthetic biology. Here, taking efficient production of salidroside as an example of glycosides, we design and construct a syntrophic Escherichia coli-E. coil coculture composed of the aglycone (AG) strain and the glycoside (GD) strain, which convergently accommodate biosynthetic pathways of tyrosol and salidroside, respectively. To accomplish this the phenylalanine-deficient AG strain was engineered to utilize xylose preferentially and to overproduce precursor tyrosol, while the tyrosine-deficient GD strain was constructed to consume glucose exclusively and to enhance another precursor UDP-glucose availability for synthesis of salidroside. The AG and GD strains in the synthetic consortium are obligatory cooperators through crossfeeding of tyrosine and phenylalanine and compatible in glucose and xylose mixture. Through balancing the metabolic pathway strength, we show that the syntrophic coculture was robust and stable, and produced 6.03 g/L of salidroside. It was the de novo production of salidroside for the first time in E. coil coculture system, which would be applicable for production of other important glycosides and natural products.
C1 [Liu, Xue; Li, Xiao-Bo; Jiang, Jianlan; Liu, Zhen-Ning; Qiao, Bin; Li, Fei-Fei; Cheng, Jing-Sheng; Sun, Xiaocui; Yuan, Ying-Jin; Qiao, Jianjun; Zhao, Guang-Rong] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Sch Chem Engn & Technol, Yaguan Rd 135, Tianjin 300350, Peoples R China.
   [Cheng, Jing-Sheng; Yuan, Ying-Jin; Qiao, Jianjun; Zhao, Guang-Rong] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, SynBio Res Platform, Yaguan Rd 135, Tianjin 300350, Peoples R China.
C3 Tianjin University; Nankai University; Tianjin University; Collaborative
   Innovation Center of Chemical Science & Engineering Tianjin
RP Qiao, JJ; Zhao, GR (corresponding author), Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Sch Chem Engn & Technol, Yaguan Rd 135, Tianjin 300350, Peoples R China.
EM Jianjunq@tju.edu.cn; grzhao@tju.edu.cn
RI ; Yuan, Ying-jin/A-3144-2009
OI Li, Xiaobo/0000-0002-4984-0081; Cheng, jingsheng/0000-0001-9508-3723; 
FU National Basic Research Program of China [2014CB745102]; National
   Natural Science Foundation of China [31570087]
FX This work was supported by the National Basic Research Program of China
   (2014CB745102), and the National Natural Science Foundation of China
   (31570087). We acknowledge NBRP-E. coli at NIG for providing strains.
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U1 13
U2 293
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7176
EI 1096-7184
J9 METAB ENG
JI Metab. Eng.
PD MAY
PY 2018
VL 47
BP 243
EP 253
DI 10.1016/j.ymben.2018.03.016
PG 11
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA GH4YZ
UT WOS:000433423600024
PM 29596994
DA 2026-05-27
ER

PT J
AU Yao, YY
   Li, F
   Jin, H
   Zhang, YS
   Xue, JH
   Wang, HJ
   Zhou, XL
   Hong, HR
   Chen, F
AF Yao, Yunyi
   Li, Fan
   Jin, Hua
   Zhang, Yanshan
   Xue, Jianhong
   Wang, Huijuan
   Zhou, Xiaoli
   Hong, Huarong
   Chen, Fang
TI The effects of salidroside on transcription factors and cell growth
   inhibition in human lung adenocarcinoma epithelial cells
SO AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE Salidroside; adenocarcinoma epithelial cells; c-Myc; P21; cell cycle;
   cell viability
ID C-MYC; CANCER CELLS; DEGRADATION; PROGRESSION; MECHANISMS; EXPRESSION;
   EXTRACT
AB Salidroside is thought to be one of the compounds from Rhodioladumulosa, responsible for neuroprotective, antidepressant, anxiolytic and anti-tumor actions. Our research focused on the effects of Salidroside on transcription factors and cell cycle inhibitors in A549 cells. We found out that the gene and protein expression of c-Myc were down-regulated significantly, while it was the opposite with P21. C-fos is slightly down-regulated mainly on mRNA level while P27 is slightly up-regulated both on mRNA level and protein level. No significant changes have been detected on c-jun and CEBP-alpha. This suggested that c-Myc and P21 may play a key role in the pharmacological action of Salidroside. Also, we found that the growth of A549 cells was inhibited and the cell cycle was arrested at G0/G1 phase. P21 plays an important role in cell growth inhibition via cell cycle arrest.
C1 [Yao, Yunyi; Chen, Fang] Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China.
   [Li, Fan; Xue, Jianhong] Chinese Peoples Liberat Army Gen Hosp, Int Med Ctr, Beijing 100853, Peoples R China.
   [Jin, Hua] Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Gynecol Oncol 2, Urumqi 830011, Peoples R China.
   [Zhang, Yanshan; Wang, Huijuan] Tumor Hosp Wuwei, Wuwei 733000, Peoples R China.
   [Zhou, Xiaoli] Sichuan Prov Sch Hlth, Chengdu 610100, Sichuan, Peoples R China.
   [Hong, Huarong] Chengdu Med Coll, Sch Basic Med Sci, Chengdu 610083, Peoples R China.
C3 Sichuan University; Chinese People's Liberation Army General Hospital;
   Xinjiang Medical University; Chengdu Medical College
RP Chen, F (corresponding author), Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China.
EM fangchen151@yahoo.com.cn
RI /AAC-5724-2021
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NR 24
TC 0
Z9 1
U1 0
U2 4
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0816
J9 AFR J PHARM PHARMACO
JI Afr. J. Pharm. Pharmacol.
PD MAR
PY 2012
VL 6
IS 12
BP 893
EP 898
DI 10.5897/AJPP11.808
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 938YB
UT WOS:000303768400005
OA gold
DA 2026-05-27
ER

PT J
AU Wang, ZY
   Yang, RL
   Wang, JZ
   Bi, YH
   Zhu, C
   Zhao, XJ
   Nie, LH
   Li, WQ
AF Wang, Zhaoyu
   Yang, Rongling
   Wang, Jizhong
   Bi, Yanhong
   Zhu, Chun
   Zhao, Xiangjie
   Nie, Linghong
   Li, Wenqian
TI Regioselective Synthesis of β-D-Glucopyranosides and Their
   Analogs by Plant Seed-Derived β-Glycosidases
SO JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
LA English
DT Article
DE Enzymatic Glycosylation; Organic Solvent; Prunus persica Seed;
   Salidroside
ID ENZYMATIC-SYNTHESIS; NATURAL-PRODUCTS; SALIDROSIDE; FLAVONOIDS;
   COSOLVENT; LIPASE; OPTIMIZATION; GLUCOSIDES; ACYLATION; IMPROVE
AB Regioselective enzymatic glycosylation of D-glucose and various structural alcohols for synthesizing beta-D-glucopyranosides was successfully conducted. Among the beta-glycosidases from seven potential plant seeds, the low-cost beta-glycosidase from Prunus persic a seed displayed excellent activity for salidroside preparation. Several crucial parameters, such as the solvent, buffer pH, buffer content, substrate molar ratio, enzyme dosage, and temperature were examined for yield optimization. Under the optimal conditions, the initial reaction rate and yield of salidroside were as high as 3.04 mM/h and 18.90%, respectively. Moreover, the alcohol acceptor recognition of the enzyme in synthesizing beta-D-glucopyranosides was also investigated. The experimental data indicated that beta-glycosidase activity and yield varied widely among all the tested alcohols due to the specific spatial structures of various acceptors.
C1 [Wang, Zhaoyu; Yang, Rongling; Wang, Jizhong; Bi, Yanhong; Zhu, Chun; Zhao, Xiangjie; Nie, Linghong; Li, Wenqian] Huaiyin Inst Technol, Sch Life Sci & Food Engn, Huaian 223003, Peoples R China.
C3 Huaian University
RP Bi, YH (corresponding author), Huaiyin Inst Technol, Sch Life Sci & Food Engn, Huaian 223003, Peoples R China.
EM byhfood@126.com
RI wang, zhaoyu/IQT-3451-2023
FU National Natural Science Foundation of China [31501421]; Qing Lan
   Project of Jiangsu Province, Natural Science Foundation of Jiangsu
   Province [BK2012243]; Key Research Program of Industry and Information
   Technology of Huai'an [HAG2015031]; College Students Innovation and
   Entrepreneurship Training Projects of Jiangsu Province [HGYK201604]
FX This research was sponsored financially by the National Natural Science
   Foundation of China (31501421), Qing Lan Project of Jiangsu Province,
   Natural Science Foundation of Jiangsu Province (BK2012243), Key Research
   Program of Industry and Information Technology of Huai'an (HAG2015031),
   and College Students Innovation and Entrepreneurship Training Projects
   of Jiangsu Province (HGYK201604).
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NR 26
TC 1
Z9 2
U1 2
U2 25
PU SOC CHEMICAL ENG JAPAN
PI BUNKYO KU TOKYO
PA KYORITSU BUILDING 4-16-19 KOHINATA, BUNKYO KU TOKYO, 112, JAPAN
SN 0021-9592
J9 J CHEM ENG JPN
JI J. Chem. Eng. Jpn.
PD SEP
PY 2017
VL 50
IS 9
BP 748
EP 753
DI 10.1252/jcej.16we240
PG 6
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA FI2ST
UT WOS:000411794500011
DA 2026-05-27
ER

PT J
AU Cui, JL
   Guo, TT
   Chao, JB
   Wang, ML
   Wang, JH
AF Cui, Jinlong
   Guo, Tingting
   Chao, Jianbin
   Wang, Mengliang
   Wang, Junhong
TI Potential of the Endophytic Fungus Phialocephala fortinii Rac56
   Found in Rhodiola Plants to Produce Salidroside and
   p-Tyrosol
SO MOLECULES
LA English
DT Article
DE Phialocephala fortinii; fungal bioactivity; Rhodiola angusta;
   accumulation of active component
ID DARK SEPTATE ENDOPHYTES; BIOSYNTHESIS; PATHWAY; CELLS
AB 2-(4-Hydroxyphenyl) ehyl-fi -D-glucopyranoside (salidroside) and 4-(2-hydroxyethyl) phenol (p-tyrosol) are famous food and medicine additives originally derived from alpine Rhodiola plants. Salidroside or p-tyrosol production by the endophytic fungus Rac56 (Phialocephala fortinii) was confirmed by UPLC/Q-TOF-MS and H-1-NMR. The fermentation conditions were optimized by orthogonal design using data processing system software. The broth fermentation results showed that salidroside and p-tyrosol extraction yields from Rac56 were stable and reached 1.729 +/- 0.06 mg and 1.990 +/- 0.05 mg per mL of culture medium, respectively. The optimal conditions for salidroside and p-tyrosol production in fermentation culture of Rac56 were determined to be 25 degrees C, pH values of 7 and 5, Czapek-Dox culture medium volumes of 150 mL and 50 mL in 250 mL flasks, rotation speeds of 100x g and 200x g, and fermentation durations of 7 and 15 days, respectively. Under these optimal conditions, stable yields of 2.339 +/- 0.1093 mg and 2.002 +/- 0.0009 mg per mL of culture medium of salidroside and p-tyrosol, respectively, were obtained, indicating that the P. fortinii Rac56 strain is a promising source of these compounds.
C1 [Cui, Jinlong; Guo, Tingting; Chao, Jianbin; Wang, Mengliang; Wang, Junhong] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Peoples R China.
C3 Shanxi University
RP Wang, ML (corresponding author), Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Peoples R China.
EM CJL717@sxu.edu.cn; guott880118@163.com; chao@sxu.edu.cn;
   mlwang@sxu.edu.cn; wangjunh@sxu.edu.cn
FU National Natural Sciences Foundation of China [31270383]; Natural
   Science Foundation of Shanxi Province, China [2014011029-1]; Specialized
   Research Fund for the Doctoral Program of Higher Education of China
   [20121401120001]; Forestry Public Industry Scientific Research
   [201304326]
FX We would like to thank the financial support from National Natural
   Sciences Foundation of China (No. 31270383), Natural Science Foundation
   of Shanxi Province, China (No. 2014011029-1), Specialized Research Fund
   for the Doctoral Program of Higher Education of China (No.
   20121401120001), and Forestry Public Industry Scientific Research
   (201304326). We also thank Vinod Vijayakumar (The Ohio State University)
   for reading and correcting the manuscript.
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NR 33
TC 24
Z9 31
U1 1
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2016
VL 21
IS 4
AR 502
DI 10.3390/molecules21040502
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DK8CO
UT WOS:000375155000113
PM 27092483
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, H
   Ma, YD
   Chen, Q
   Dai, YT
   Wang, YX
   Huang, HT
   Yao, ZH
   Yan, CR
   Shi, JM
AF Liu, Hang
   Ma, Yandong
   Chen, Qian
   Dai, Yuting
   Wang, Yixuan
   Huang, Huating
   Yao, Zihan
   Yan, Chaoren
   Shi, Jingming
TI Rosavin and salidroside attenuate microglia injury via nuclear factor
   <bold>κ</bold>-B signaling pathway
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE rosavin; salidroside; beta-amyloid oligomers; neuroinflammation; NF-&
   kcy;B phosphorylation
ID ALZHEIMERS-DISEASE
AB Objectives Inflammation, oxidative harm, and degradation of mitochondria ultimately contribute to the initiation neurodegenerative changes. This study investigated the inhibitory effects of rosavin and salidroside on neuroinflammation induced by beta-amyloid oligomers using primary microglia derived from the cerebral tissue of C57BL/6 J mice.Key findings Following beta-amyloid oligomers' production, a series of continuous neurological deterioration takes place. Rosavin and salidroside exhibited distinct inhibitory effects on different neurodegenerative damage. Subsequent studies indicated that the protective mechanism of rosavin was associated with nuclear factor & kcy;-B phosphorylation.Lay summary Rhodiola rosea L., with its natural small molecule compounds like rosavin may be potential candidates for the treatment of AD.
C1 [Liu, Hang; Ma, Yandong; Chen, Qian; Dai, Yuting; Wang, Yixuan; Huang, Huating; Yao, Zihan; Yan, Chaoren; Shi, Jingming] Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altitu, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
C3 Xizang Minzu University
RP Yan, CR; Shi, JM (corresponding author), Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altitu, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
EM yanchaoren1994@163.com; jmshi@xzmu.edu.cn
RI Ma, Yandong/H-6903-2016; Shi, Jing-Ming/ACS-3321-2022; dai,
   Yuting/HPE-2336-2023; yao, zihan/HCH-0912-2022
OI Yan, Chaoren/0000-0002-5055-1893
FU National Natural Science Foundation of China [32160215]; Natural Science
   Foundation of Tibet Autonomous Region [XZ202501ZR0080, XZ202401ZR0129,
   XZ202001ZR0017G]; General project of Xizang Minzu University [23MDY05]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Grant No. 32160215), The Natural Science Foundation
   of Tibet Autonomous Region (Grant No. XZ202501ZR0080, XZ202401ZR0129,
   XZ202001ZR0017G), General project of Xizang Minzu University (Grant No.
   23MDY05).
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NR 69
TC 0
Z9 0
U1 3
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD JAN
PY 2026
VL 78
IS 1
DI 10.1093/jpp/rgaf094
EA OCT 2025
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CG2IX
UT WOS:001586215500001
PM 41042989
DA 2026-05-27
ER

PT J
AU Zhang, LC
   Li, N
   Xu, M
   Chen, JL
   He, H
   Liu, J
   Wang, TH
   Zuo, ZF
AF Zhang, Lan-Chun
   Li, Na
   Xu, Min
   Chen, Ji-Lin
   He, Hua
   Liu, Jia
   Wang, Ting-Hua
   Zuo, Zhong-Fu
TI Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy
   associated with NLRP3, NFEZL2 and NGKB1, revealed by network
   pharmacology analysis and experimental validation
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Salidroside; Diabetic Retinopathy; Pyroptosis; Network Pharmacology;
   Molecular Docking
ID HIGH GLUCOSE; ACTIVATION; INFLAMMASOME; INHIBITION; APOPTOSIS;
   MECHANISM; CELLS
AB Objective To investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular network mechanism in diabetic retinapathy (DR) rats. Methods HE, Nissl and immunofluorescence staining were used to observe the retinal morphological change, and the related target genes for salidroside, DR and pyroptosis were downloaded from GeneCard database. Then Venny, PPI, GO, KEGG analysis and molecular docking were used to reveal molecular network mechanism of SAL in inhibiting the pyroptosis of RGC. Lastly, all hub genes were confirmed by using qPCR. Results HE and Nissl staining showed that SAL could improve the pathological structure known as pyroptosis in diabetic retina, and the fluorescence detection of pyroptosis marker in DM group was the strongest, while they decreased in the SAL group(P < 0.05)). Network pharmacological analysis showed 6 intersecting genes were obtained by venny analysis. GO and KEGG analysis showed 9 biological process, 3 molecular function and 3 signaling pathways were involved. Importantly, molecular docking showed that NFE2L2, NFKB1, NLRP3, PARK2 and SIRT1 could combine with salidroside, and qPCR validates the convincible change of CASP3, NFE2L2, NFKB1, NLRP3, PARK2 and SIRT1. Conclusion Salidroside can significantly improve diabetes-inducedRGC pyrotosis in retina, in which, the underlying mechanism is associated with the NLRP3, NFEZL2 and NGKB1 regulation.
C1 [Zhang, Lan-Chun; Li, Na; Chen, Ji-Lin; Wang, Ting-Hua] Kunming Med Univ, Inst Neurosci, Dept Lab Anim Sci, Kunming 650500, Peoples R China.
   [Li, Na; Xu, Min; Wang, Ting-Hua; Zuo, Zhong-Fu] Jinzhou Med Univ, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou, Peoples R China.
   [Xu, Min; Wang, Ting-Hua; Zuo, Zhong-Fu] Jinzhou Med Univ, Coll Basic Med, Dept Anat, Jinzhou 121000, Peoples R China.
   [He, Hua; Liu, Jia] Kunming Med Univ, Haiyuan Coll, Dept Pharmacol, Kunming 650106, Yunnan, Peoples R China.
C3 Kunming Medical University; Jinzhou Medical University; Jinzhou Medical
   University; Kunming Medical University
RP Wang, TH (corresponding author), Kunming Med Univ, Inst Neurosci, Dept Lab Anim Sci, Kunming 650500, Peoples R China.; Wang, TH; Zuo, ZF (corresponding author), Jinzhou Med Univ, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou, Peoples R China.; Wang, TH; Zuo, ZF (corresponding author), Jinzhou Med Univ, Coll Basic Med, Dept Anat, Jinzhou 121000, Peoples R China.
EM wangtinghua@vip.163.com; zuozhongfu@jzmu.edu.cn
FU Translational study of microrNA-target gene regulatory network in stroke
   and acute brain injury.
FX I would like to thank Professor Zhong-Fu Zuo and Professor Ting-Hua Wang
   for their guidance.
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TC 9
Z9 12
U1 1
U2 33
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD JAN 20
PY 2024
VL 29
IS 1
AR 60
DI 10.1186/s40001-023-01578-6
PG 25
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FL7B9
UT WOS:001146002500001
PM 38243268
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, XH
   Liu, D
   Wang, YB
   Dong, M
AF Zhu, Xiaohong
   Liu, Duo
   Wang, Yanbo
   Dong, Mei
TI Salidroside suppresses nonsmall cell lung cancer cells proliferation and
   migration via microRNA-103-3p/Mzb1
SO ANTI-CANCER DRUGS
LA English
DT Article
DE MicroRNA; Mzb1; nonsmall cell lung cancer; salidroside
ID COLORECTAL-CANCER; MZB1; MIR-103; METASTASIS; INVASION; MIR-375; TARGET;
   NSCLC
AB Lung cancer is the leading cause of cancer death in both men and women in the worldwide. Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Salidroside, a glycoside of tyrosol, is isolated fromRhodiola roseaand shows anticancer functions in several cancers. Recently, studies have reported that salidroside could inhibit the proliferation and metastasis of lung cancer; however, we need to explore further mechanism to provide evidence for clinical treatment. MicroRNAs (miRNAs) are regulatory molecules frequently aberrantly expressed in cancers, and a key role in carcinogenesis through regulation of their target genes. Consistent with previous reports, we found that salidroside could inhibit the proliferation of nonsmall cell lung cancer (NSCLC) cells, and elevated the level of miR-103-3p. Furthermore, we showed that the level of miR-103-3p was significantly downregulated in NSCLC tissues and NSCLC cell lines A549 and H460 and was significantly correlated with NSCLC proliferation and metastasis. Further studies indicated that an endoplasmic reticulum calcium regulatorMzb1(marginal zone B and B-1 cell-specific protein) was a direct target gene of miR-103-3p, evidenced by the direct binding of miR-103-3p with the 3 ' untranslated region ofMzb1. We have also shown that overexpressing Mzb1 was able to inhibit the suppression effect of miR-103-3p on A549 migration and metastasis. These results demonstrate that salidroside suppresses NSCLC proliferation and metastasis by regulating miR-103-3p/Mzb1.
C1 [Zhu, Xiaohong; Liu, Duo; Wang, Yanbo; Dong, Mei] Harbin Med Univ Canc Hosp, Dept Pharm, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University
RP Dong, M (corresponding author), Harbin Med Univ Canc Hosp, Dept Pharm, Harbin, Heilongjiang, Peoples R China.
EM 13804567370@163.com
RI ZHU, XIAOHONG/ACC-4255-2022
OI Wang, Yanbo/0000-0003-3428-4585
FU Scientific Research Fund of Heilongjiang Provincial Education Department
   (the Special Project for Youth Scholars) [2017LCZX75]
FX This study was supported by Scientific Research Fund of Heilongjiang
   Provincial Education Department (the Special Project for Youth Scholars,
   2017LCZX75). This declaration acknowledges that this paper adheres to
   the principles for transparent reporting and scientifirigor of
   preclinical research recommended by funding agencies, publishers, and
   other organizations engaged with supporting research.
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Z9 40
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-4973
EI 1473-5741
J9 ANTI-CANCER DRUG
JI Anti-Cancer Drugs
PD AUG
PY 2020
VL 31
IS 7
BP 663
EP 671
DI 10.1097/CAD.0000000000000926
PG 9
WC Oncology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pharmacology & Pharmacy
GA NE7EA
UT WOS:000562763100002
PM 32304408
DA 2026-05-27
ER

PT J
AU Meng, XY
   Fu, WQ
   Huo, ML
   Liu, YQ
   Zhang, ZX
   Wei, JF
   Wang, ZH
   Abliz, Z
AF Meng, Xianyue
   Fu, Wenqing
   Huo, Meiling
   Liu, Yaqi
   Zhang, Zixuan
   Wei, Jinfeng
   Wang, Zhonghua
   Abliz, Zeper
TI In situ label-free visualization of tissue distributions of salidroside
   in multiple mouse organs by MALDI-MS imaging
SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
LA English
DT Article
DE Mass spectrometry imaging; MALDI; Salidroside; Tissue distributions;
   1,5-Diaminonaphthalene hydrochloride
ID MASS-SPECTROMETRY; RAT PLASMA; QUANTITATIVE-DETERMINATION;
   RHODIOLA-ROSEA; MATRIX; TYROSOL
AB Detailed knowledge on the spatiotemporal distribution of drugs or drug candidates in bio-tissues is of vital importance for the determination of their underlying mechanisms of action as well as evaluation of potential side effects. The present work involved the establishment of a matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) method for the visualization of distribution of salidroside, a bioactive ingredient of Rhodiola L. Crassulaceae, in multiple mouse tissue sections. 1,5-Diaminonaphthalene (1,5-DAN) hydrochloride was selected as the most suitable matrix by comparing the signal intensity produced by MALDI-MS analysis following cocrystallization of salidroside with different matrix candidates. The matrix deposition procedure was systematically optimized to obtain the best sensitivity as well as homogeneous matrix coverage on the tissue sections. The measurements were carried out in the negative reflectron ion mode (m/z 300-350 Da) with a spatial resolution of 200 mm. The proposed method demonstrated good performance with respect to specificity, linearity, and sensitivity, and the method exhibited a relatively reasonable run time. The approach was applied to determine the temporal-spatial location of salidroside in the kidney, liver, spleen, heart, lung, and brain following intravenous administration of the drug in mice. The results indicate that salidroside exhibited a heterogeneous distribution in the kidney and heart, and it can be rapidly eliminated by kidney 5 min after administration. The distribution information obtained by the in situ and label-free imaging technique proposed herein may benefit to our understanding of the activities and potential transient toxicities of salidroside in various organs. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Meng, Xianyue; Fu, Wenqing; Huo, Meiling; Liu, Yaqi; Wang, Zhonghua; Abliz, Zeper] Minzu Univ China, Coll Life & Environm Sci, Ctr Imaging & Syst Biol, Beijing 100081, Peoples R China.
   [Zhang, Zixuan; Wei, Jinfeng] Beijing Union Genius Pharmaceut Technol Dev Co Lt, Beijing 100050, Peoples R China.
   [Wang, Zhonghua; Abliz, Zeper] Minzu Univ China, Minist Educ, Key Lab Ethnomed, Beijing 100081, Peoples R China.
   [Abliz, Zeper] Minzu Univ China, Sch Pharm, Beijing 100081, Peoples R China.
C3 Minzu University of China
RP Wang, ZH (corresponding author), Coll Life & Environm Sci, Ctr Imaging & Syst Biol, 27 Zhongguancun South Rd, Beijing 100081, Peoples R China.
EM wangzhonghua@muc.edu.cn
RI wei, Jinfeng/OEP-0492-2025
FU National Key Research and Development Program of China [2017YFC1704000];
   National Natural Science Foundation of China [81803483]
FX This research was supported by the National Key Research and Development
   Program of China (No. 2017YFC1704000) and National Natural Science
   Foundation of China (Grant No. 81803483).
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PU ELSEVIER
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PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1387-3806
EI 1873-2798
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JI Int. J. Mass Spectrom.
PD JUL
PY 2020
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AR 116347
DI 10.1016/j.ijms.2020.116347
PG 7
WC Physics, Atomic, Molecular & Chemical; Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physics; Spectroscopy
GA LT2JZ
UT WOS:000536899900007
DA 2026-05-27
ER

PT J
AU Zheng, H
   Yan, W
   Zuo, ZF
   Liu, XZ
AF Zheng, He
   Yan, Wei
   Zuo, Zhongfu
   Liu, Xuezheng
TI Fabrication of an electrochemical sensor based on molecular imprinting
   strategy for detecting salidroside
SO INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
LA English
DT Article
DE Molecular imprinting; Electrochemical sensor; Salidroside; Multi -walled
   carbon nanotubes; Selectivity
ID RAT PLASMA; QUANTITATIVE-DETERMINATION; TYROSOL
AB In recent years, molecular imprinting has emerged as a promising strategy for developing highly selective and sensitive sensors for various analytes. In this study, we present the fabrication and characterization of an electrochemical sensor based on the molecular imprinting strategy for the detection of salidroside, a bioactive compound found in Rhodiola rosea. The sensor employs a modified glassy carbon electrode functionalized with multi-walled carbon nanotubes (MWCNTs) as the working electrode. The molecularly imprinted polymer (MIP) was prepared using acrylamide as the functional monomer and MWCNTs as the supporting material. The MIPbased sensor exhibited exceptional sensitivity and selectivity towards salidroside, showing a linear correlation between the logarithm of salidroside concentration and the reduced peak current in the range of 1 nM to 1 mu M, with a low detection limit of 0.51 nM. The sensor demonstrated excellent reproducibility and stability, with a relative standard deviation (RSD) of 3.1 % for parallel measurements and 94.8 % retained response after a 7-day storage period. The spiked recovery experiments for Rhodiola rosea samples yielded high accuracy and precision, with recovery rates ranging from 96 % to 99 % and RSDs of 1-4 %. The developed MIP-based electrochemical sensor offers a powerful and reliable approach for the detection of salidroside, holding great potential for applications in pharmaceutical and herbal medicine industries.
C1 [Zheng, He; Yan, Wei; Liu, Xuezheng] Guangxi Med Univ, Dept Anat Histol & Embryol, Nanning 530021, Peoples R China.
   [Zheng, He; Yan, Wei] Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121000, Peoples R China.
   [Zuo, Zhongfu; Liu, Xuezheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou 121000, Peoples R China.
   [Zuo, Zhongfu] Guangxi Med Univ, Dept Anat Histol & Embryol, Postdoctoral Res Stn, Nanning 530021, Peoples R China.
C3 Guangxi Medical University; Jinzhou Medical University; Jinzhou Medical
   University; Guangxi Medical University
RP Liu, XZ (corresponding author), Guangxi Med Univ, Dept Anat Histol & Embryol, Nanning 530021, Peoples R China.
EM jzykdxlxz@163.com
FU National Natural Science Foundation of China [81571383, 81300931]; China
   Postdoctoral Science Foundation [2017M612870]
FX <BOLD>Acknowledgements</BOLD> This work was supported by National
   Natural Science Foundation of China (No: 81571383, 81300931) and China
   Postdoctoral Science Foundation (2017M612870) .
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NR 39
TC 6
Z9 6
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1452-3981
J9 INT J ELECTROCHEM SC
JI Int. J. Electrochem. Sci.
PD DEC
PY 2023
VL 18
IS 12
AR 100367
DI 10.1016/j.ijoes.2023.100367
EA OCT 2023
PG 7
WC Electrochemistry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Electrochemistry
GA FX4I2
UT WOS:001149133900001
OA gold
DA 2026-05-27
ER

PT J
AU Guo, YB
   Li, XH
   Zuao, YH
   Si, YX
   Zhu, H
   Yang, YM
AF Guo, Yibing
   Li, Xiaohong
   Zuao, Yahong
   Si, Yongxing
   Zhu, Hui
   Yang, Yumin
TI Synthesis and Biological Evaluation of Two Salidroside Analogues in the
   PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE salidroside; analogues; N-acetylglucosamine; hypoglycemia; PC12 cell
AB Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rowel L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, two analogues were prepared with the glucosamine and N-acetylglucosamine as glycosyl donor, 2-(4-hydroxyphenyl)ethanol as glycosyl acceptor. The effects of them over PC12 cell model exposed to hypoglycemia and serum limitation were assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Flow Cytometry and Western blot analysis.
C1 [Guo, Yibing; Zuao, Yahong; Si, Yongxing; Yang, Yumin] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
   [Guo, Yibing; Li, Xiaohong; Zhu, Hui] Nantong Univ, Affiliated Hosp, Surg Comprehens Lab, Nantong 226001, Jiangsu, Peoples R China.
   [Guo, Yibing] Nantong Univ, Sch Med, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM yangym@ntu.edu.cn
RI Li, XiaoHong/POY-6271-2026
OI Guo, Yibing/0000-0001-9723-0678
FU Hi-Tech Research and Development Program of China (863 Program)
   [2006AA02A128]; Nature Science Foundation of China [30970713]; Basic
   Research Program of Jiangsu Province [BK2009518]; Jiangsu Higher
   Education Institutions
FX The financial supports of Hi-Tech Research and Development Program of
   China (863 Program, Grant No.2006AA02A128), Nature Science Foundation of
   China (Grant No. 30970713), Basic Research Program of Jiangsu Province
   (Grant No. BK2009518) and the Priority Academic Program Development of
   Jiangsu Higher Education Institutions are gratefully acknowledged.
CR Akiyama K, 1995, CARBOHYD RES, V279, P151, DOI 10.1016/0008-6215(95)00288-X
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NR 15
TC 3
Z9 3
U1 0
U2 17
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD AUG
PY 2011
VL 59
IS 8
BP 1045
EP 1047
DI 10.1248/cpb.59.1045
PG 3
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 815HJ
UT WOS:000294516400020
PM 21804252
OA Bronze
DA 2026-05-27
ER

PT J
AU Guo, N
   Ding, WM
   Wang, Y
   Hu, ZW
   Wang, ZM
   Wang, Y
AF Guo, Na
   Ding, Weimin
   Wang, Yu
   Hu, Zhiwei
   Wang, Ziming
   Wang, Yang
TI An LC-MS/MS method for the determination of salidroside and its
   metabolite p-tyrosol in rat liver tissues
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE LC-MS/MS; method validation; p-tyrosol; salidroside; tissue distribution
ID TANDEM MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; PLASMA;
   PHARMACOKINETICS; EXTRACTION; EXCRETION; INJURY; VALIDATION; GLYCOSIDES;
   CELLS
AB Context: Salidroside and its metabolite p-tyrosol are two major phenols in the genus Rhodiola L. (Crassulaceae). They have been confirmed to possess various pharmacological properties and are used for the prophylaxis and therapeutics of many diseases. Several analytical methods have been developed for the determination of the two compounds in plant materials and biological plasma matrices. However, these methods are not optimal for biological samples containing complex organic interferences, such as liver and brain tissues. Objective: This study aimed to further develop and validate a simple and specific LC-MS/ MS method for the determination of salidroside and its metabolite p-tyrosol in rat liver tissues using paracetamol as the internal standard (IS).
   Materials and methods: Salidroside and p-tyrosol with the IS paracetamol and liver tissues were used as model compounds and biological samples. Samples were processed by protein precipitation (PP) with methanol, the supernatant was dried under nitrogen and the residue was reconstituted in a mobile phase that consisted of a mixture of acetonitrile and water (1:9,v/ v). Salidroside and p-tyrosol were detected in negative mode under multiple reaction monitoring (MRM) by a triple quadrupole tandem mass spectrometer coupled with electrospray ionization.
   Results: Standard curves were linear over the concentration range of 50-2000 ng/ mL with correlation coefficients of 0.995 or better for both salidroside and p-tyrosol. The intra-and inter-day accuracy for salidroside ranged between 104.90 and 112.73% with a precision of 3.51-14.27%. For p-tyrosol, the intra-and inter-day accuracy was between 92.38 and 100.59%, and the precision was 8.54% or less. The stability data showed that no significant degradation occurred under the experimental conditions. The recoveries were 111.44, 108.10, and 102.00% for salidroside at concentrations of 50, 500 and 2000 ng/ mL, respectively, and were 105.44, 105.50, and 113.04% for tyrosol at concentrations of 50, 500 and 2000 ng/ mL, respectively. The matrix effects were 83.85-92.45% for salidroside and 85.61-92.49% for p-tyrosol at three QC levels. This method was successfully applied to a liver tissue distribution study of salidroside and its metabolite p-tyrosol in rats.
   Discussion and conclusion: This newly established method is validated as simple, reliable and accurate. It can be used as a valid analytical method for the intrinsic quality control of biological matrices, especially tissue samples.
C1 [Guo, Na] Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin, Peoples R China.
   [Guo, Na; Ding, Weimin; Wang, Yu; Hu, Zhiwei; Wang, Ziming; Wang, Yang] Northeast Forestry Univ, Minist Educ, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Alkali Soil Nat Environm Sci Ctr, Harbin, Peoples R China.
   [Ding, Weimin] Harbin Univ Sci & Technol, Sch Chem & Environm Engn, Harbin, Peoples R China.
C3 Harbin Institute of Technology; Northeast Forestry University - China;
   Harbin University of Science & Technology
RP Wang, Y (corresponding author), Northeast Forestry Univ, Minist Educ, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Alkali Soil Nat Environm Sci Ctr, Harbin, Peoples R China.
EM ywang@nefu.edu.cn
CR Bartholome R, 2010, DRUG METAB PHARMACOK, V25, P379, DOI 10.2133/dmpk.DMPK-10-RG-002
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NR 31
TC 15
Z9 18
U1 0
U2 63
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD MAY
PY 2014
VL 52
IS 5
BP 637
EP 645
DI 10.3109/13880209.2013.863946
PG 9
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA AF2CD
UT WOS:000334519300016
PM 24479765
OA Bronze
DA 2026-05-27
ER

PT J
AU Yu, HL
   He, YH
   She, YX
   Wang, M
   Yan, Z
   Ren, JH
   Cao, Z
   Shao, Y
   Wang, SS
   Abd El-Aty, AM
   Hacimuftuoglu, A
   Wang, J
AF Yu, Hailong
   He, Yahui
   She, Yongxin
   Wang, Miao
   Yan, Zheng
   Ren, Jian Hua
   Cao, Zhen
   Shao, Yong
   Wang, Shanshan
   Abd El-Aty, A. M.
   Hacimuftuoglu, Ahmet
   Wang, Jing
TI Preparation of molecularly imprinted polymers coupled with
   high-performance liquid chromatography for the selective extraction of
   salidroside from Rhodiola crenulata
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
   AND LIFE SCIENCES
LA English
DT Article
DE MIP; Rhodiola crenulata; HPLC; Active compound; Salidroside
ID MICROWAVE-ASSISTED EXTRACTION; TRADITIONAL CHINESE MEDICINE; SOLID-PHASE
   MICROEXTRACTION; MONOLITHIC COLUMN; SEPARATION; SENSOR; COMBINATION;
   SYSTEM; PLANTS; GREEN
AB Salidroside is one of the bio-active compounds found in Rhodiola crenulata. To find an easy, time saving and efficient way to extract, purify and enrich salidroside from Rhodiola and other natural plants, we prepared a highly selective molecularly imprinted polymer (MIP) for extraction and preconcentration of salidroside using salidroside (SD) as a template, acrylamide (AM) as a functional monomer, ethylene glycol dimethacrylate (EDMA) as a crosslinking monomer, and dimethyl formamide (DMF) as a porogen. The performance of the MIPs was evaluated through selective recognition capacity and adsorption isotherms and kinetics. The results showed that MIPs possessed excellent specific recognition toward SD and could effectively discriminate its structural analogue. The application of the developed MIPs as a selective sorbent for solid-phase extraction (SPE) of SD was also investigated. Under the optimum conditions, a rapid, economical, and efficient method based upon MIP-SPE coupled with high-performance liquid chromatography (HPLC) was developed for the determination of SD in Rhodiola crenulata. The method showed satisfactory recoveries (from spiked real samples at 3 fortification levels of 0.5, 1 and 10 mg L-1) of 88.74%-97.64% with relative standard deviations (RSDs) ranging from 2.05%-3.54%. Furthermore, MIP-SPE was successfully used to separate and purify SD from different parts in Rhodiola crenulata and it should be available for determination of salidroside in others herbs.
C1 [Yu, Hailong; He, Yahui; She, Yongxin; Wang, Miao; Cao, Zhen; Shao, Yong; Wang, Shanshan; Wang, Jing] Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agriprod, Beijing 100081, Peoples R China.
   [Yu, Hailong; He, Yahui; She, Yongxin; Wang, Miao; Cao, Zhen; Shao, Yong; Wang, Jing] Minist Agr, Key Lab Agrifood Safety & Qual, Beijing 100081, Peoples R China.
   [Yu, Hailong; Yan, Zheng; Ren, Jian Hua] Beijing Polytech, Coll Bioengn, Beijing 100176, Peoples R China.
   [Abd El-Aty, A. M.] Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt.
   [Abd El-Aty, A. M.; Hacimuftuoglu, Ahmet] Ataturk Univ, Med Fac, Dept Med Pharmacol, TR-25240 Erzurum, Turkey.
   [He, Yahui] Beijing Purkinje Gen Iinstrument Co Ltd, Beijing 100081, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Institute of Quality Standards
   & Testing Technology for Agro-Products, CAAS; Beijing Polytechnic
   University; Egyptian Knowledge Bank (EKB); Cairo University; Ataturk
   University
RP She, YX; Wang, J (corresponding author), Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agriprod, Beijing 100081, Peoples R China.
EM sheyongxin@caas.cn; wangjing05@caas.cn
RI Hacimuftuoglu, Ahmet/U-9109-2018; 王, 淼/ITU-8408-2023; Shao,
   Yong/IUO-6811-2023; Abd El-Aty, A. M/H-8216-2018
OI Yongxin, She/0000-0001-7055-4808; Abd El-Aty, A. M/0000-0001-6596-7907;
   Cao, Zhen/0000-0003-1259-6107
FU National Natural Science Foundation of China [31471654, 31772071];
   Science Technology Foundation of Beijing Municipal Commission of
   Education [KM201810858002]; China Agriculture Research System
   [CARS-05-05A-03]
FX This work was supported by the National Natural Science Foundation of
   China (Contract No. 31471654, 31772071), The Science Technology
   Foundation of Beijing Municipal Commission of Education
   (KM201810858002), and the China Agriculture Research System (NO.
   CARS-05-05A-03).
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NR 39
TC 21
Z9 25
U1 3
U2 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD JUN 15
PY 2019
VL 1118
BP 180
EP 186
DI 10.1016/j.jchromb.2019.04.004
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HZ9CO
UT WOS:000469153600022
PM 31054452
DA 2026-05-27
ER

PT J
AU Wang, K
   Qi, TT
   Guo, LC
   Ma, ZX
   Gu, GF
   Xiao, M
   Lu, LL
AF Wang, Ke
   Qi, Tingting
   Guo, Longcheng
   Ma, Zhongxuan
   Gu, Guofeng
   Xiao, Min
   Lu, Lili
TI Enzymatic Glucosylation of Salidroside from Starch by α-Amylase
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE alpha-amylases; purification; glycosylation; starch; salidroside
ID BETA-GALACTOSIDASE; BACILLUS-SUBTILIS; IN-VITRO; NEUROPROTECTION;
   INJURY; RATS
AB alpha-Amylases are among the most important and widely used industrial enzymes for starch processing. In this work, an alpha-amylase from Bacillus subtilis XL8 was purified and found to possess both hydrolysis and transglycosylation activities. The optimal pH and temperature for starch hydrolysis were pH 5.0 and 70 degrees C, respectively. The enzyme could degrade soluble starch into beneficial malto-oligosaccharides ranging from dimer to hexamer. More importantly, it was able to catalyze alpha-glycosyl transfer from the soluble starch to salidroside, a medicinal plant-derived component with broad pharmacological properties. The transglycosylation reaction catalyzed by the enzyme generated six derivatives in a total high yield of 73.4% when incubating with 100 mg/mL soluble starch and 50 mM salidroside (pH 7.5) at 50 degrees C for 2 h. These derivatives were identified as alpha-1,4-glucosyl, maltosyl, maltotriosyl, maltotetraosyl, maltopentaosyl, and maltohexaosyl salidrosides, respectively. They were novel promising compounds that might integrate the bioactive functions of malto-oligosaccharides and salidroside.
C1 [Wang, Ke; Lu, Lili] Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
   [Qi, Tingting; Guo, Longcheng; Ma, Zhongxuan; Gu, Guofeng; Xiao, Min; Lu, Lili] Shandong Univ, Natl Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China.
C3 Huazhong University of Science & Technology; Shandong University
RP Lu, LL (corresponding author), Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.; Xiao, M; Lu, LL (corresponding author), Shandong Univ, Natl Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China.
EM minxiao@sdu.edu.cn; lililu@hust.edu.cn
OI Guo, Longcheng/0000-0003-4409-7935
FU National Natural Science Foundation of China [21877044, 31872626,
   31670062]; Fundamental Research Funds for the Central Universities
   [2018KFYYXJJ020]
FX This work was supported by National Natural Science Foundation of China
   (Grants 21877044, 31872626, and 31670062) and Fundamental Research Funds
   for the Central Universities (Grant 2018KFYYXJJ020).
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NR 34
TC 17
Z9 18
U1 2
U2 55
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD FEB 20
PY 2019
VL 67
IS 7
BP 2012
EP 2019
DI 10.1021/acs.jafc.8b06618
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Agriculture; Chemistry; Food Science & Technology
GA HM7EZ
UT WOS:000459641900024
PM 30678460
DA 2026-05-27
ER

PT J
AU Zheng, C
   Guo, YB
   Meng, Y
   Dou, SF
   Shao, J
   Yang, YM
AF Zheng, Cheng
   Guo, Yibing
   Meng, Ying
   Dou, SuFeng
   Shao, Jian
   Yang, YuMin
TI Synthesis of salidroside analogues and their ability of DPPH radical
   scavenging activity
SO INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING
   MEDICINAL CHEMISTRY
LA English
DT Article
DE Salidroside; analogues; Koenigs-Knorr method; DPPH
ID RHODIOLA-SACHALINENSIS; EFFICIENT SYNTHESIS; ALKYL ARYL; CONSTITUENTS;
   ROSEA; PERFORMANCE; GLYCOSIDE; BARK
AB Salidroside is a phenylpropanoid glycoside isolated from Rhodiolarosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 22 novel glycosides have been synthesized and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenge activity of each glycoside has been evaluated. 2-(3,4,5-Trihydroxyphenyl)ethyl beta-D-galactopyranoside and 3-(3,4,5-trihydroxyphenyl)propyl beta-D-glucopyranoside exhibit significant activity prior to salidroside and Vitamin C with EC50 values of 35.85 mu M and 36.71 mu M; respectively. The results indicate that the phenolic hydroxyl group of these compounds is important for radical scavenging activity and phenyl ring substitution by electron-donating substituents lead to increased antioxidant activity.
C1 [Zheng, Cheng; Meng, Ying; Dou, SuFeng; Yang, YuMin] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
   [Guo, Yibing] Nantong Univ, Surg Comprehens Lab, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China.
   [Shao, Jian] Nantong Univ, Sch Chem & Chem Engn, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM yangym@ntu.edu.cn
OI Guo, Yibing/0000-0001-9723-0678
FU Nature Science Foundation of Nantong University and Nantong City
   [12ZY035, AS2011016]; Nature Science Foundation of China [21242005,
   81171457]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions
FX Financial support from the Nature Science Foundation of Nantong
   University and Nantong City (Grant no.12ZY035; AS2011016) and Nature
   Science Foundation of China (Grant no.21242005 and 81171457), a Project
   Funded by the Priority Academic Program Development of Jiangsu Higher
   Education Institutions are gratefully acknowledged.
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NR 30
TC 4
Z9 5
U1 0
U2 13
PU NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI, 110 012, INDIA
SN 0376-4699
EI 0019-5103
J9 INDIAN J CHEM B
JI Indian J. Chem. Sect B-Org. Chem. Incl. Med. Chem.
PD MAY
PY 2013
VL 52
IS 5
BP 654
EP 664
PG 11
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Chemistry
GA 150EF
UT WOS:000319372300003
DA 2026-05-27
ER

PT J
AU Li, Y
   Shao, CH
   Park, SY
   Piao, XC
   Lian, ML
AF Li, Yang
   Shao, Chun-Hui
   Park, So-Young
   Piao, Xuan-Chun
   Lian, Mei-Lan
TI Production of salidroside and polysaccharides in Rhodiola
   sachalinensis using airlift bioreactor systems
SO ACTA PHYSIOLOGIAE PLANTARUM
LA English
DT Article
DE Air volume; Inoculum density; Medium pH; Methyl jasmonate; Salidroside;
   Polysaccharides
ID HAIRY ROOT CULTURES; CELL-SUSPENSION CULTURES; ADVENTITIOUS ROOTS;
   ENHANCED PRODUCTION; PANAX-GINSENG; SECONDARY METABOLITES; INOCULUM
   DENSITY; AERATION VOLUME; SCALE CULTURE; BIOMASS
AB Rhodiola sachalinensis is widely used in traditional Chinese medicine, and salidroside and polysaccharides are its important bioactive compounds. This study used airlift bioreactor systems to produce mass bioactive compounds through callus culture. Several factors affecting callus biomass and bioactive compound accumulation were investigated. Callus growth was vigorous in a bioreactor system, and the growth ratio was 2.8-fold higher in bioreactor culture than in agitated-flask culture. Callus biomass and polysaccharide content were favorable at 0.1 air volume per culture volume per min (vvm), whereas favorable salidroside content was observed at a high air volume (0.2 vvm). The maximum yields of salidroside (7.90 mg l(-1)) and polysaccharide (2.87 g l(-1)) were obtained at 0.1 vvm. Inoculum density greatly affected callus biomass and bioactive compound accumulation, and the highest biomass and contents or yields of salidroside and polysaccharide were determined at a high inoculum density of 12.5 g l(-1). The level of hydrogen ion concentration (pH) at 5.8 improved callus biomass accumulation. Acidic medium (pH 4.8) stimulated salidroside synthesis but higher pH level (7.8) promoted polysaccharide accumulation. The highest yields of both bioactive compounds were obtained at pH 5.8. Methyl jasmonate (MeJA) participated in synthesis promotion of bioactive compounds, and the contents and yields of salidroside [4.75 mg g(-1) dry weight (DW), 58.43 mg l(-1)] and polysaccharides (392.41 mg g(-1) DW, 4.79 g l(-1)) were at maximum at 125 and 150 mu mol of MeJA. Therefore, bioreactor systems can be used to produce R. sachalinensis bioactive compounds, and callus culture in a bioreactor can be as an alternative method for supplying materials for commercial drug production.
C1 [Li, Yang; Shao, Chun-Hui; Piao, Xuan-Chun; Lian, Mei-Lan] Yanbian Univ, Key Lab Nat Resource Changbai Mt & Funct Mol, Minist Educ, Yanji 133002, Jilin, Peoples R China.
   [Park, So-Young] Chungbuk Natl Univ, Dept Hort Sci, Cheongju 361763, South Korea.
C3 Yanbian University; Chungbuk National University
RP Piao, XC (corresponding author), Yanbian Univ, Key Lab Nat Resource Changbai Mt & Funct Mol, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
EM nyypxc@ybu.edu.cn; lianmeilan2001@163.com
FU National Science Foundation of China [81160497]
FX This research was supported by the National Science Foundation of China
   (81160497).
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NR 49
TC 8
Z9 10
U1 1
U2 53
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0137-5881
EI 1861-1664
J9 ACTA PHYSIOL PLANT
JI Acta Physiol. Plant.
PD NOV
PY 2014
VL 36
IS 11
BP 2975
EP 2983
DI 10.1007/s11738-014-1669-7
PG 9
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA AR0UH
UT WOS:000343286500014
DA 2026-05-27
ER

PT J
AU Xu, MC
   Gao, XF
   Ruan, CW
   Ge, ZR
   Lu, JD
   Zhang, JJ
   Zhang, Y
   Wang, L
   Shi, HM
AF Xu, Mao-Chun
   Gao, Xiu-Fang
   Ruan, Changwu
   Ge, Zhi-Ru
   Lu, Ji-De
   Zhang, Jian-Jun
   Zhang, Yu
   Wang, Lu
   Shi, Hai-Ming
TI miR-103 Regulates Oxidative Stress by Targeting the BCL2/Adenovirus E1B
   19 kDa Interacting Protein 3 in HUVECs
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CARDIAC MYOCYTE DEATH; SALIDROSIDE PROTECTS; HYPOXIA; EXPRESSION;
   MICRORNAS; APOPTOSIS; INJURY
AB Oxidative stress plays a critical role in cardiovascular diseases. Salidroside, a glycoside from Rhodiola rosea, has been used as an antioxidative therapy for oxidative injury in cardiac diseases. However, the mechanism underlying its antioxidant effect needs to be elucidated. Treatment of HUVECs with H2O2 significantly decreased the expression of miR-103 in a dose- and time-dependent manner, whereas pretreatment with salidroside significantly inhibited this decrease. Subsequent analysis showed that overexpression of miR-103 abrogated cell activity and ROS production induced by H2O2. Bcl2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) was determined to be a novel miR-103 target in HUVECs. Interestingly, H2O2 treatment upregulated BNIP3 expression; in turn, this effect was inhibited by pretreatment with salidroside. Further studies confirmed that the knockdown of BNIP3 enhanced cell activity and suppressed the ROS production induced by H2O2. These results demonstrated for the first time that salidroside protects HUVECs in part by upregulating the expression of miR-103, which mediates BNIP3 downregulation and plays an important role in the cytoprotective actions.
C1 [Xu, Mao-Chun; Ruan, Changwu; Ge, Zhi-Ru; Lu, Ji-De; Zhang, Jian-Jun; Zhang, Yu; Wang, Lu] Gongli Hosp, Shanghai Pudong New Area, Dept Cardiol, Shanghai 200135, Peoples R China.
   [Gao, Xiu-Fang; Shi, Hai-Ming] Fudan Univ, Huashan Hosp, Dept Cardiol, Shanghai 200040, Peoples R China.
C3 Fudan University
RP Gao, XF (corresponding author), Fudan Univ, Huashan Hosp, Dept Cardiol, Shanghai 200040, Peoples R China.
EM sophiakao@126.com
FU Pudong New Area leading academic discipline project
FX The authors thank Xuchao Zhu (Tongji University, Shanghai, China) for
   experimental design and language editing. The study was funded by the
   Pudong New Area leading academic discipline project.
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NR 34
TC 25
Z9 27
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 489647
DI 10.1155/2015/489647
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CI9XU
UT WOS:000355124700001
PM 26000071
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhuang, XY
   Maimaitijiang, A
   Li, Y
   Shi, HM
   Jiang, XF
AF Zhuang, Xinyu
   Maimaitijiang, Alimujiang
   Li, Yong
   Shi, Haiming
   Jiang, Xiaofei
TI Salidroside inhibits high-glucose induced proliferation of vascular
   smooth muscle cells via inhibiting mitochondrial fission and oxidative
   stress
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; mitochondrial fission; reactive oxygen species;
   proliferation; high glucose; Mdivi-1
ID DIABETES-MELLITUS; THERAPEUTIC TARGET; RHODIOLA-ROSEA; HYPERGLYCEMIA;
   HYPERPROLIFERATION; APOPTOSIS; DISEASES; STROKE; IMPACT; DRP1
AB The mitochondria are highly dynamic organelles, carefully maintaining network homeostasis by regulating mitochondrial fusion and fission. Mitochondrial dynamics are involved in the regulation of a variety of pathophysiological processes, including cell proliferation. Oxidative stress serves an important role in the remodeling of arterial vascular tissue in diabetic patients by affecting the proliferation of vascular smooth muscle cells (VSMCs). Salidroside is the primary active component of Rhodiola rosea and has been demonstrated to be an antioxidant with cardio- and vascular-protective effects, in addition to improving glucose metabolism. Therefore, the present study aimed to examine the impact of Salidroside on VSMC proliferation, reactive oxygen species (ROS) generation and mitochondrial dynamics under high glucose conditions and the potential mechanisms involved. The current study used Salidroside and a mitochondrial division inhibitor, specifically of Drp1 (Mdivi-1) to treat VSMCs under high glucose conditions for 24 h and assessed VSMCs proliferation, the state of mitochondrial fission and fusion and the expression level of proteins related to mitochondrial dynamics including dynamin-related protein (Drp1) and mitofusin 2 (Mfn2), ROS level and nicotinamide adenine dinucleotide phosphate oxidase activity. The results of the present study indicate that Salidroside and Mdivi-1 inhibit VSMC proliferation, Drp1 expression and oxidative stress and upregulate Mfn2 expression (all P<0.05). The inhibitive effect on VSMC proliferation may be partly reversed by exogenous ROS. In addition, the inhibitive effect on VSMCs proliferation and oxidative stress may also be in part reversed by Mfn2-siRNA. Collectively, these data suggest that Salidroside inhibits VSMCs proliferation induced by high-glucose and may perform its therapeutic effect via maintaining mitochondrial dynamic homeostasis and regulating oxidative stress level, with Mfn2 as a therapeutic target.
C1 [Zhuang, Xinyu; Maimaitijiang, Alimujiang; Li, Yong; Shi, Haiming; Jiang, Xiaofei] Fudan Univ, Huashan Hosp, Dept Cardiol, 12 South Wulumuqi Rd, Shanghai 200036, Peoples R China.
C3 Fudan University
RP Jiang, XF (corresponding author), Fudan Univ, Huashan Hosp, Dept Cardiol, 12 South Wulumuqi Rd, Shanghai 200036, Peoples R China.
EM sule_jiang@126.com
RI Zhuang, Xinyu/KQU-2437-2024
FU National Natural Science Foundation of China [81573710]; Chinese
   Medicine Science Foundation of Shanghai Health and Family Planning
   Committee [2014JZ006A]; Natural Science Foundation of Shanghai
   [13ZR1404900]
FX The present study was supported by the National Natural Science
   Foundation of China (grant no. 81573710), the Chinese Medicine Science
   Foundation of Shanghai Health and Family Planning Committee (grant no.
   2014JZ006A) and the Natural Science Foundation of Shanghai (grant no.
   13ZR1404900).
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NR 37
TC 40
Z9 43
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUL
PY 2017
VL 14
IS 1
BP 515
EP 524
DI 10.3892/etm.2017.4541
PN B
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FA7RV
UT WOS:000405645500008
PM 28672961
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guo, YB
   Zheng, C
   Xu, W
   Si, YX
   Dou, SF
   Yang, YM
AF Guo, Yibing
   Zheng, Cheng
   Xu, Wen
   Si, Yongxing
   Dou, Sufeng
   Yang, Yumin
TI Free radical scavenging and hepatoprotective effects of salidroside
   analogs on CCl4-induced cytotoxicity in LO2 cells
SO MEDICINAL CHEMISTRY RESEARCH
LA English
DT Article
DE Salidroside; Analogs; Hepatoprotective effects; DPPH
ID INDUCED TOXICITY; CONSTITUENTS; INJURY; MICE; CCL4
AB Salidroside, a phenylpropanoid glycoside isolated from a traditional Chinese medicinal plant Rhodiola rosea L. displays a broad spectrum of pharmacological properties. It has been found to play a hepatoprotective role in liver diseases through inhibiting apoptosis of hepatocytes and proliferation of hepatic stellate cells, decreasing serum aminotransferase, reversing hepatic fibrosis, and improving liver function. In this study as an ongoing study on the discovery and development of new hepatoprotective agents, about 12 novel glycosides were synthesized, and 2,2-diphenyl-1-picrylhydrazyl radical scavenge activity of each glycoside was evaluated. 2-(3,4,5-trihydroxyphenyl)ethyl beta-d-glucopyranoside (4g) and 2-(3,4,5-trihydroxyphenyl)ethyl beta-d-galactopyranoside (4h) exhibited significant activity prior to salidroside with an IC50 value of 38.05 and 35.85 mu M, respectively. The hepatoprotective effect of compounds 4g and 4h on CCl4-induced cytotoxicity in LO2 cells was assessed for further research.
   2-(3,4,5-Trihydroxyphenyl)ethyl beta-d-glucopyranoside (4g) and 2-(3,4,5-trihydroxyphenyl)ethyl beta-d-galactopyranoside (4h) exhibited significant hepatoprotective activity prior to salidroside.
C1 [Guo, Yibing] Nantong Univ, Surg Comprehens Lab, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China.
   [Zheng, Cheng; Xu, Wen; Si, Yongxing; Dou, Sufeng; Yang, Yumin] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM yangym@ntu.edu.cn
OI Guo, Yibing/0000-0001-9723-0678
FU Natural Science Foundation of Nantong University, Nantong Municipality
   [11Z011, AS2011016]; National Natural Science Foundation of China
   [81171457]; Priority Academic Program Development of Jiangsu Higher
   Education Institution
FX Financial supports from the Natural Science Foundation of Nantong
   University, Nantong Municipality (Grant No. 11Z011; AS2011016) and the
   National Natural Science Foundation of China (Grant No. 81171457) are
   gratefully acknowledged. This is also a project funded by the Priority
   Academic Program Development of Jiangsu Higher Education Institution.
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NR 18
TC 12
Z9 15
U1 0
U2 62
PU SPRINGER BIRKHAUSER
PI NEW YORK
PA 233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA
SN 1054-2523
EI 1554-8120
J9 MED CHEM RES
JI Med. Chem. Res.
PD MAY
PY 2013
VL 22
IS 5
BP 2524
EP 2530
DI 10.1007/s00044-012-0247-z
PG 7
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 116WC
UT WOS:000316912800049
DA 2026-05-27
ER

PT J
AU Li, WL
   Qiu, GP
   Kang, MJ
   Zhang, C
   Quan, W
   Zhou, H
   Fan, XK
   Luo, J
   Lu, BY
   Li, MQ
AF Li, Wenlan
   Qiu, Guoping
   Kang, Manjun
   Zhang, Can
   Quan, Wei
   Zhou, Hui
   Fan, Xiankang
   Luo, Jie
   Lu, Baiyi
   Li, Maiquan
TI Insights into the dual inhibitory effects of phenylethanoid glycosides
   from Osmanthus fragrans flower on glycolipid metabolizing
   enzymes
SO BIOORGANIC CHEMISTRY
LA English
DT Article
DE Salidroside; Acteoside; Dual inhibitory effects; Glycolipid metabolizing
   enzymes; Interaction mechanism
ID BOVINE SERUM-ALBUMIN; BINDING INTERACTION; MULTI-SPECTROSCOPY;
   PANCREATIC LIPASE; ALPHA-AMYLASE; ACTEOSIDE; ACID; SALIDROSIDE; TISSUE
AB Obesity is consistently associated with dysregulated glycolipid metabolism. The regulation of alpha-amylase and pancreatic lipase plays a pivotal role in maintaining glucose and lipid homeostasis. In this study, we demonstrated that Osmanthus fragrans flower phenylethanoid glycoside-rich extract (OFE) effectively suppressed alpha-amylase activity through mixed-type inhibition and pancreatic lipase activity via competitive inhibition. Molecular docking analysis revealed that acteoside and salidroside bond to the amino acid residues of these enzymes primarily through hydrogen bonding and hydrophobic effect. Further investigation using UV-vis and fluorescence spectroscopy indicated that acteoside interacted with alpha-amylase via static quenching and with pancreatic lipase through dynamic quenching. Interestingly, while acteoside quenched the fluorescence of both enzymes, salidroside enhanced their fluorescence. Circular dichroism spectroscopy analysis showed distinct structural effects: acteoside increased alpha-helix and beta-sheet content while reducing beta-turn and random coil structures, whereas salidroside elevated alpha-helix and beta-sheet content but decreased beta-turn and random coil formation. Our findings demonstrate that acteoside and salidroside are effective natural inhibitors of alpha-amylase and pancreatic lipase, supporting the potential of Osmanthus fragrans flower as a dietary intervention for glycolipid metabolism disorders.
C1 [Li, Wenlan; Qiu, Guoping; Kang, Manjun; Zhang, Can; Quan, Wei; Zhou, Hui; Fan, Xiankang; Luo, Jie; Li, Maiquan] Hunan Agr Univ, Minist Educ, Natl Res Ctr Engn Technol Utilizat Funct Ingredien, Coll Food Sci & Technol,Key Lab Tea Sci, Changsha 410128, Peoples R China.
   [Lu, Baiyi; Li, Maiquan] Zhejiang Univ, Minist Agr & Rural Affairs, Coll Biosyst Engn & Food Sci, Key Lab Qual Evaluat & Hlth Benefit Agroprod, Hangzhou 310058, Peoples R China.
C3 Hunan Agricultural University; Zhejiang University
RP Luo, J; Li, MQ (corresponding author), Hunan Agr Univ, Minist Educ, Natl Res Ctr Engn Technol Utilizat Funct Ingredien, Coll Food Sci & Technol,Key Lab Tea Sci, Changsha 410128, Peoples R China.; Lu, BY; Li, MQ (corresponding author), Zhejiang Univ, Minist Agr & Rural Affairs, Coll Biosyst Engn & Food Sci, Key Lab Qual Evaluat & Hlth Benefit Agroprod, Hangzhou 310058, Peoples R China.
EM luojie@hunau.edu.cn; bylu@zju.edu.cn; limaiquan@hunau.edu.cn
RI Yang, Bowen/KWV-0501-2024; Fan, Xiankang/HLV-7171-2023
FU National Natural Science Foundation of China [32222077]; Open Funding of
   Key Laboratory of Quality Evaluation and Health Benefit of Agricultural
   Products, Ministry of Agriculture and Rural Affairs, P.R. China
   [ZJU-APQHLAB-2402]; Natural Science Foundation of Hunan Province
   [2024JJ5187]; Scientific Research Foundation of Hunan Provincial
   Education Department [23A0187]
FX This research was funded by the the National Natural Science Foundation
   of China (32222077), Open Funding of Key Laboratory of Quality
   Evaluation and Health Benefit of Agricultural Products, Ministry of
   Agriculture and Rural Affairs, P.R. China (ZJU-APQHLAB-2402), Natural
   Science Foundation of Hunan Province (2024JJ5187), the Scientific
   Research Foundation of Hunan Provincial Education Department (23A0187) .
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NR 55
TC 2
Z9 2
U1 6
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0045-2068
EI 1090-2120
J9 BIOORG CHEM
JI Bioorganic Chem.
PD JAN
PY 2026
VL 168
AR 109328
DI 10.1016/j.bioorg.2025.109328
EA DEC 2025
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Z3170
UT WOS:001642490000001
PM 41401698
DA 2026-05-27
ER

PT J
AU Zhang, J
   Zhen, YF
   Pu-Bu-Ci-Ren
   Song, LG
   Kong, WN
   Shao, TM
   Li, X
   Chai, XQ
AF Zhang, Jia
   Zhen, Yan-feng
   Pu-Bu-Ci-Ren
   Song, Li-gang
   Kong, Wei-na
   Shao, Tie-mei
   Li, Xue
   Chai, Xi-qing
TI Salidroside attenuates beta amyloid-induced cognitive deficits
   via modulating oxidative stress and inflammatory mediators in rat
   hippocampus
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Salidroside; Alzheimer's disease; Cognitive deficit; Oxidative stress;
   NADPH oxidase; Nuclear factor-kappa B
ID GLYCATION END-PRODUCTS; FACTOR-KAPPA-B; ALZHEIMERS-DISEASE; NADPH
   OXIDASE; MOUSE MODEL; PC12 CELLS; ACTIVATION; RAGE; RECEPTOR; HYPOTHESIS
AB Beta amyloid (A beta)-induced oxidative stress and chronic inflammation in the brain are considered to be responsible for the pathogenesis of Alzheimer's disease (AD). Salidroside, the major active ingredient of Rhodiola crenulata, has been previously shown to have antioxidant and neuroprotective properties in vitro. The present study aimed to investigate the protective effects of salidroside on A beta-induced cognitive impairment in vivo. Rats received intrahippocampal A beta(1-40) injection were treated with salidroside (25,50 and 75 mg/kg p.o.) once daily for 21 days. Learning and memory performance were assessed in the Morris water maze (days 17-21). After behavioral testing, the rats were sacrificed and hippocampi were removed for biochemical assays (reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), acetylcholinesterase (AChE), acetylcholine (ACh)) and molecular biological analysis (Cu/Zn-SOD, Mn-SOD, GPx, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, nuclear factor kappa B (NF-kappa B), inhibitor of kappa B-alpha (I kappa B alpha), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), receptor for advanced glycation end products (RAGE)). Our results confirmed that A beta(1-40) peptide caused learning and memory deficits in rats. Further analysis demonstrated that the NADPH oxidase-mediated oxidative stress was increased in A beta(1-40)-injected rats. Furthermore, NF-KB was demonstrated to be activated in A beta(1-40)-injected rats, and the COX-2, iNOS and RAGE expression were also induced by A beta(1-40). However, salidroside (50 and 75 mg/kg p.o.) reversed all the former alterations. Thus, the study indicates that salidroside may have a protective effect against AD via modulating oxidative stress and inflammatory mediators. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Zhang, Jia; Song, Li-gang; Chai, Xi-qing] Hebei Med Univ, Affiliated Hosp 1, Dept Neurol, Shijiazhuang 050017, Peoples R China.
   [Zhen, Yan-feng] Hebei Med Univ, Tangshan Gongren Hosp, Dept Endocrinol 2, Tangshan 063000, Peoples R China.
   [Pu-Bu-Ci-Ren] Armed Police Forces, Tibetan Gen Hosp, Dept Special Consultat, Lhasa 850000, Peoples R China.
   [Pu-Bu-Ci-Ren; Chai, Xi-qing] Brain Ageing & Cognit Neurosci Lab Hebei Prov, Shijiazhuang 050017, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Chai, XQ (corresponding author), Hebei Chem & Pharmaceut Coll, 88 Fangxing Rd, Shijiazhuang 050026, Peoples R China.
EM wenlong6540@sina.com; jane791115@126.com; qundian@126.com;
   songlg001@gmail.com; kongweina0219@163.com; shaotiemei@sina.com;
   lixue712@126.com; xqchai1@sina.com
FU National Natural Science Foundation of China [81273983]; Natural Science
   Foundation of Hebei Province, China [C2010001471]
FX We thank Dr. Xiao-li Xie, Rui Zhang and Yue-Ping Liu for giving their
   help for the experiments. We also thank Prof. Mei Han, Wei Zhang and
   Ai-ying Li for critical reading of the manuscript and comment. This
   research was supported by the National Natural Science Foundation of
   China (No. 81273983) and the Natural Science Foundation of Hebei
   Province, China (No. C2010001471).
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NR 78
TC 126
Z9 146
U1 3
U2 108
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD MAY 1
PY 2013
VL 244
BP 70
EP 81
DI 10.1016/j.bbr.2013.01.037
PG 12
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 115SV
UT WOS:000316833100009
PM 23396166
DA 2026-05-27
ER

PT J
AU Zhang, J
   Zhu, KK
   Wang, KM
   Jiang, CS
AF Zhang, Juan
   Zhu, Kong-Kai
   Wang, Kai-Ming
   Jiang, Cheng-Shi
TI Design, synthesis, and neuroprotective activity of salidroside-based
   dual inhibitors of selective monoamine oxidase B and amyloid-β
   aggregation
SO MEDICINAL CHEMISTRY RESEARCH
LA English
DT Article
DE Salidroside derivatives; MAO-B inhibitor; A beta aggregation inhibitor;
   Neuroprotection; Alzheimer's disease
ID BIOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; DERIVATIVES; HYBRIDS
AB This study focuses on the design, synthesis, and evaluation of a series of salidroside derivatives (pOBZ-1 similar to pOBZ-11) for their potential as inhibitors of monoamine oxidase B (MAO-B) and amyloid beta (A beta(42)) aggregation, and neuroprotective agents. Among the synthesized derivatives, pOBZ-1 and pOBZ-2 exhibited superior MAO-B inhibitory activity compared to salidroside, with notable selectivity over MAO-A. These compounds demonstrated linear competitive inhibition. Additionally, the derivatives effectively inhibited A beta(42) aggregation and protected SH-SY5Y cells from A beta(42) and hydrogen peroxide (H2O2)-induced neurotoxicity. The findings suggest that pOBZ-2, in particular, holds promise as a therapeutic candidate for Alzheimer's disease.
   [GRAPHICS]
   .
C1 [Zhang, Juan; Wang, Kai-Ming; Jiang, Cheng-Shi] Univ Jinan, Sch Biol Sci & Technol, Jinan, Peoples R China.
   [Zhu, Kong-Kai] Shandong Univ, Shandong Prov ENT Hosp, Dept Otolaryngol Head & Neck Surg, Jinan, Shandong, Peoples R China.
C3 University of Jinan; Shandong University
RP Wang, KM; Jiang, CS (corresponding author), Univ Jinan, Sch Biol Sci & Technol, Jinan, Peoples R China.
EM bio_wangkm@ujn.edu.cn; bio_jiangcs@ujn.edu.cn
RI Zhu, Kongkai/KXR-0886-2024; Wang, Kaiming/OOK-3134-2025
OI Jiang, Cheng-Shi/0000-0002-2760-7596
FU National Natural Science Foundation of China [21672082]; Natural Science
   Foundation of Shandong Province [ZR2023MB046]
FX This work was finally supported by the National Natural Science
   Foundation of China (No. 21672082), and the Natural Science Foundation
   of Shandong Province (No. ZR2023MB046).
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NR 47
TC 2
Z9 2
U1 2
U2 2
PU SPRINGER BIRKHAUSER
PI NEW YORK
PA 233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA
SN 1054-2523
EI 1554-8120
J9 MED CHEM RES
JI Med. Chem. Res.
PD MAR
PY 2025
VL 34
IS 3
BP 625
EP 637
DI 10.1007/s00044-024-03367-0
EA JAN 2025
PG 13
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Y4U7O
UT WOS:001389065200001
DA 2026-05-27
ER

PT J
AU Yang, KC
   Qi, XZ
   He, MS
   Song, KG
   Luo, F
   Qu, XY
   Wang, GX
   Ling, F
AF Yang, Kechen
   Qi, Xiaozhou
   He, Maosheng
   Song, Kaige
   Luo, Fei
   Qu, Xiangyu
   Wang, Gaoxue
   Ling, Fei
TI Dietary supplementation of salidroside increases immune response and
   disease resistance of crucian carp (Carassius auratus) against
   Aeromonas hydrophila
SO FISH & SHELLFISH IMMUNOLOGY
LA English
DT Article
DE Salidroside; Crucian carp; Aeromonas hydrophila; Immunity; Disease
   resistance
ID GENE-EXPRESSION; GROWTH-PERFORMANCE; ANTIOXIDANT STATUS; RHODIOLA-ROSEA;
   TROUT; FISH; EXTRACTS; SYSTEM; L.
AB Some medicinal plants have been known as immunostimulants, and the medicinal plants extract has been used to control the outbreak of the disease in aquaculture for many years. In this study, a total of 270 crucian carp (30 +/- 5 g) were randomly distributed in 9 aquaria (55 cm l x 40 cm w x 50 cm h) and divided into three feeding groups including 0 (Control), 50 mg kg(-1) (Diet A) and 100 mg kg(-1) (Diet B) of salidroside. The expression of immune-related genes (IL-1 beta, TNF alpha, MYD88, CXCL-8, TGF-beta, and IL-11) in the kidney had a significant increase when the crucian carp fed with Diet B for 4 weeks (P < 0.05). Meanwhile, the expression of IL-1 beta, TNF alpha, and CXCL-8 in the spleen was significantly up-regulated when the fish fed with Diet B (P < 0.05). Higher serum alkaline phosphatase (AKP) activity, catalase (CAT) activity, superoxide dismutase (SOD) activity, and complement C3 content were found in the fish which fed with salidroside-supplemented diet. Our results also proved that fish fed with salidroside-supplemented diet for four weeks, especially at a concentration of 100 mg kg(-1) diet, improved the protection of crucian carp against A. hydrophila. The amount of A. hydrophila in the kidney and spleen was significantly decreased in salidroside-supplemented diet groups (P < 0.05). In conclusion, the present results demonstrate that the addition of salidroside for four weeks can improve the immune response of crucian carp and increase the protection against the pathogen, especially at the concentration of 100 mg kg(-1) diet. The protective effect of the salidroside to the crucian carp could be used as alternatives to antibiotics for controlling fish diseases in aquaculture.
C1 [Yang, Kechen; Qi, Xiaozhou; He, Maosheng; Song, Kaige; Luo, Fei; Qu, Xiangyu; Wang, Gaoxue; Ling, Fei] Northwest A&F Univ, Xinong Rd 22nd, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Wang, GX; Ling, F (corresponding author), Northwest A&F Univ, Xinong Rd 22nd, Yangling 712100, Shaanxi, Peoples R China.
EM wanggaoxue@126.com; feiling@nwsuaf.edu.cn
RI Qu, Xiangyu/AGX-8316-2022; xiaozhou, Qi/ITV-5616-2023; Ling,
   Fei/K-9860-2016; Ling, Fei/K-9860-2016
OI Wang, Gaoxue/0000-0001-9465-108X; Ling, Fei/0000-0002-1687-1519; Luo,
   Fei/0000-0002-4326-6015
FU Shaanxi Science & Technology Co-ordination & Innovation Project
   [2015KTTSNY01-02]; College Students' Innovative Entrepreneurial Training
   Plan Program [201810712070]
FX This research was supported by the Shaanxi Science & Technology
   Co-ordination & Innovation Project (NO.2015KTTSNY01-02) and College
   Students' Innovative Entrepreneurial Training Plan Program
   (201810712070).
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NR 54
TC 19
Z9 22
U1 1
U2 53
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1050-4648
EI 1095-9947
J9 FISH SHELLFISH IMMUN
JI Fish Shellfish Immunol.
PD NOV
PY 2020
VL 106
BP 1
EP 7
DI 10.1016/j.fsi.2020.07.054
PG 7
WC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
GA OC9SD
UT WOS:000579494400001
PM 32731013
DA 2026-05-27
ER

PT J
AU Zhou, MJ
   Zheng, L
   Guo, L
   Liu, WL
   Lv, C
   Jiang, LH
   Ou, CS
   Ding, ZH
AF Zhou Mei Juan
   Zheng Li
   Guo Ling
   Liu Wei Ling
   Lv Chao
   Jiang Li Hong
   Ou Cheng Shan
   Ding Zhen Hua
TI Differential Responses to UVB Irradiation in Human Keratinocytes and
   Epidermoid Carcinoma Cells
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Article
DE UVB; G1-S phase arrest; HaCaT; A431; NF-kappa B; BCL-2; CDK6;
   Salidroside
ID NF-KAPPA-B; ULTRAVIOLET-B; CYCLE ARREST; HACAT CELLS; APOPTOSIS;
   SALIDROSIDE; FIBROBLASTS; ACTIVATION; PROTECTION; REPAIR
AB Objective To examine UVB-induced responses in normal human keratinocytes (HaCaT) and epidermoid carcinoma cells (A431) at the cellular and molecular level, and investigated the protective effect of salidroside.
   Methods Cells irradiated by UVB at various dosage and their viability was assessed by MU assays, cell cycle was analysed by flow cytometry. The expression of NF-kappa B, BCL-2, and CDK6 after 50 J/m(2) UVB irradiation were detected by RT-PCR and western blotting.
   Results Our results confirmed greater tolerance of A341 cells to UVB-induced damage such as cell viability and cell cycle arrest, which was accompanied by differential expression changes in NF-kappa B, BCL-2, and CDK6. UVB exposure resulted in HaCaT cells undergoing G(1)-S phase arrest. When treated with salidroside, HaCaT survival was significantly enhanced following exposure to UVB, suggesting great therapeutic potential for this compound.
   Conclusion Taken together, our study suggests that A431 respond differently to UVB than normal HaCaT cells, and supports a role for NF-kappa B, CDK6, and BCL-2 in UVB-induced cell G1-S phase arrest. Furthermore, salidroside can effectively protect HaCaT from UVB irradiation.
C1 [Zhou Mei Juan; Zheng Li; Guo Ling; Liu Wei Ling; Lv Chao; Jiang Li Hong; Ou Cheng Shan; Ding Zhen Hua] So Med Univ, Sch Publ Hlth & Trop Med, Dept Radiat Med, Guangzhou 510515, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Ding, ZH (corresponding author), So Med Univ, Sch Publ Hlth & Trop Med, Dept Radiat Med, Guangzhou 510515, Guangdong, Peoples R China.
EM dingzh@smu.edu.cn
RI Guo, Ling/JVZ-8417-2024
OI Guo, Ling/0000-0003-1118-6798
FU National Natural Science Foundation of China [30970673, 81172634];
   Natural Science Foundation of Guangdong Province [9151022501000013,
   S2011040003686]; Guangdong Province "211 Project" [200826GW, 201007GW];
   School of Public Health and Tropical Medicine of Southern Medical
   University, China [GW201111]
FX This work was supported by the National Natural Science Foundation of
   China (30970673, 81172634), Natural Science Foundation of Guangdong
   Province (9151022501000013, S2011040003686), Guangdong Province "211
   Project" (200826GW, 201007GW) and Grant from School of Public Health and
   Tropical Medicine of Southern Medical University, China (Grant No.
   GW201111).
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NR 28
TC 14
Z9 15
U1 0
U2 16
PU CHINESE CENTER DISEASE CONTROL & PREVENTION
PI BEIJING
PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA
SN 0895-3988
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD OCT
PY 2012
VL 25
IS 5
BP 583
EP 589
DI 10.3967/0895-3988.2012.05.013
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 045QQ
UT WOS:000311712300013
PM 23122317
DA 2026-05-27
ER

PT J
AU Wei, YL
   Du, HJ
   Lin, YP
   Wu, ML
   Xu, RA
AF Wei, Yan-Li
   Du, Hong-Jian
   Lin, Yi-Ping
   Wu, Mei-Ling
   Xu, Ren-ai
TI Effects of salidroside on rat CYP enzymes by a cocktail of probe drugs
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Cytochrome P450; Cocktail; Enzyme; Herb-drug interaction; Salidroside
ID HUMAN CYTOCHROME-P450 2D6; INTERINDIVIDUAL VARIATIONS; BREAST-CANCER;
   POLYMORPHISM; IMPACT; METABOLISM; RESPONSES; MICE
AB Objective(s): In this study, we aimed to evaluate the effect of salidroside on the activities of the different drug-metabolizing enzymes CYP1A2, CYP2B6, CYP2C9, CYP2D6 and CYP3A4 in rats, in which a specific probe drug was used for each enzyme.
   Materials and Methods: After pretreatment with salidroside, five probe drugs were simultaneously administered to rats by gavage. The given dose was 2.0 mg/kg for phenacetin (CYP1A2 activity), 4.0 mg/kg for bupropion (CYP2B6 activity), 2.0 mg/kg for losartan (CYP2C9 activity), 8.0 mg/kg for metoprolol (CYP2D6 activity) and 1.0 mg/kg for midazolam (CYP3A4 activity). Then, an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to analyze the concentrations of rats' blood, which were collected at different corresponding times.
   Results: Our data showed that salidroside exhibited an inductive effect on CYP1A2, CYP2B6, CYP2C9 and CYP3A4 activities by changing the main pharmacokinetic parameters (t1/2, CL/F, Cmax and AUC(0-infinity)) of the four probe drugs in rats. However, no significant changes in CYP2D6 activity were observed.
   Conclusion: In a word, the results displayed that salidroside could induce the activities of CYP1A2, CYP2B6, CYP2C9 and CYP3A4, which may influence the disposition of the drugs that are mainly metabolized by these pathways. Our research can provide the basis for the study of related herb-drug interactions in clinic.
C1 [Wei, Yan-Li; Du, Hong-Jian; Lin, Yi-Ping; Wu, Mei-Ling] Jinhua Polytech, Jinhua 321007, Zhejiang, Peoples R China.
   [Xu, Ren-ai] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Jinhua University of Vocational Technology; Wenzhou Medical University
RP Xu, RA (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
EM ysxurenai@hotmail.com
FU Science Technology Department of Zhejiang Province; Analytical Testing
   Science Technology Project [2016C37089]; Jinhua Science and Technology
   Bureau [2015-3-061]
FX We thank 318 Laboratory for excellent technical support. This study was
   supported by grants from the Science Technology Department of Zhejiang
   Province, Analytical Testing Science Technology Project (No. 2016C37089)
   and Jinhua Science and Technology Bureau (No. 2015-3-061).
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NR 26
TC 9
Z9 12
U1 0
U2 9
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD APR
PY 2018
VL 21
IS 4
BP 422
EP 426
DI 10.22038/IJBMS.2018.26106.6414
PG 5
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GH4FM
UT WOS:000433358700013
PM 29796228
DA 2026-05-27
ER

PT J
AU Hu, Y
   Lv, XM
   Zhang, J
   Meng, XL
AF Hu, Yao
   Lv, Xiumei
   Zhang, Jing
   Meng, Xianli
TI Comparative Study on the Protective Effects of Salidroside and Hypoxic
   Preconditioning for Attenuating Anoxia-Induced Apoptosis in
   Pheochromocytoma (PC12) Cells
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Anoxia; Apoptosis; Medicine, Chinese Traditional
ID MITOCHONDRIAL PERMEABILITY TRANSITION; PEROXIDE-INDUCED APOPTOSIS;
   NEURONS; BCL-2; INJURY; DEATH; DYSFUNCTION; CASPASES; RATS; PORE
AB Background: Hypoxia is an important sign that can result from body injuries or a special condition such as being at a high altitude or deep water diving. In the current studies, hypoxic preconditioning (HPC) plays a key role in reducing hypoxia-induced apoptosis. We aimed to study the pharmacologic preconditioning effects of salidroside versus those of HPC in hypoxia-/anoxia-induced apoptosis in PC12 cells (pheochromocytoma).
   Material/Methods: PC12 cells were treated by different experimental conditions: control condition, hypoxia condition, HPC condition, low-/middle-/high-dose condition of salidroside, cyclosporine A (CsA), and oratractyloside (ATR). The cell viability, lactate dehydrogenase (LDH) activity, apoptosis, mitochondrial membrane potential (MMP), intracellular Ca2+, caspase-3 activity, and expression of Bcl-2 were detected in PC12 cells after the hypoxia treatment. Salidroside, extracted from the traditional Chinese herb Rhodiola rosea L, plays an essential role in reducing hypoxia-induced apoptosis in PC12 cells by the mitochondrial pathway.
   Results: Salidroside decreased the apoptosis and increased the viability of hypoxia-induced PC12 cells more effectively than HPC Moreover, salidroside markedly stabilized MMP and intracellular Ca2+, reduced or inhibited LDH and caspase-3 activity, and up-regulated Bcl-2; CsA and ATR showed corresponding function.
   Conclusions: Salidroside administration restrains apoptosis induced by hypoxia in PC12 cells. The protective effects are mediated by preservation of mitochondrial integrity and MMP to inhibit the excessive Ca2+ influx and caspase-3 activity and to promote the Bcl-2 expression, providing a potential clinical and effective therapeutic mechanism to reduce deaths from ischemic or hypoxic injury.
C1 [Hu, Yao; Lv, Xiumei; Zhang, Jing; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhang, J (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
EM 31649123@qq.com
FU National Natural Science Foundation of China [81203000]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81203000)
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NR 30
TC 20
Z9 25
U1 0
U2 26
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD OCT 30
PY 2016
VL 22
BP 4082
EP 4091
DI 10.12659/MSM.897640
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EA4IA
UT WOS:000386573600001
PM 27794583
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Tan, Y
   Zou, YF
   Zhang, HB
   Liu, X
   Qian, CY
   Liu, MW
AF Tan, Yang
   Zou, Yong-Fan
   Zhang, Huang-Bo
   Liu, Xu
   Qian, Chuan-Yun
   Liu, Ming-Wei
TI The protective mechanism of salidroside modulating miR-199a-5p/TNFAIP8L2
   on lipopolysaccharide-induced MLE-12 cells
SO INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
LA English
DT Article
DE lipopolysaccharide; salidroside; mouse alveolar epithelial type II
   cells; miR-199a-5p; inflammatory response
ID ACUTE LUNG INJURY; MICRORNAS
AB Objectives Salidroside is used for treating inflammation-based diseases; however, its molecular mechanism is unclear. In this study, we determined the protective role of salidroside on the endotoxin-induced damage caused to the mouse alveolar epithelial type II (MLE-12) cells and its underlying mechanism. Methods An in vitro model for acute lung injury was constructed by inducing the MLE-12 cells using lipopolysaccharide (lipopolysaccharides, 1 mg/L). Then, The MTT assay was conducted to assess the survival rate of the MLE-12 cells in the different groups. After the treatment, apoptosis of MLE-12 cells was determined, and the mRNA and protein expression of miR-199a-5p, HMGB1, NF-kB65, TNFAIP8L2, p-IkB-alpha, and TLR4 was estimated by Western Blotting and RT-PCR. ELISA was also used to measure the concentration of inflammatory cytokine molecules IL-1 beta, IL-6, TNF-alpha, and IL-18 in the cell-free supernatant. Lastly, cell morphology was examined using the AO/EB technique. Results We showed that salidroside reduced the protein and gene expression of HMGB1, NF-kB65, miR-199a-5p, p-IkB-alpha, and TLR4, whereas it increased the gene and protein expression of TNFAIP8L2. Furthermore, it decreased the concentrations of cytokine molecules like IL-1 beta, IL-6, TNF-alpha, and IL-18 in the cell-free supernatant. MLE-12 also showed a lower apoptosis rate, higher survival rate, and better cell morphology. Conclusion Salidroside significantly inhibited the LPS-induced MLE-12 cell damage. Our results suggest that this could be by reducing miR-199a-5p and enhancing TNFAIP8L2 expression.
C1 [Tan, Yang; Zou, Yong-Fan; Qian, Chuan-Yun; Liu, Ming-Wei] Kunming Med Univ, Dept Emergency Med, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China.
   [Zhang, Huang-Bo] Kunming Med Univ, Trauma Ctr, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China.
   [Liu, Xu] Yan An Hosp Kunming City, Dept Infect Dis, Kunming, Yunnan, Peoples R China.
C3 Kunming Medical University; Kunming Medical University
RP Liu, MW (corresponding author), Kunming Med Univ, Dept Emergency Med, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China.
EM lmw2004210@163.com
RI Liu, Ming-wei/AFL-8981-2022
OI Liu, Ming-wei/0000-0002-3728-2350
FU Yunnan Provincial Department of Education Project [2019J1228]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Yunnan Provincial Department of Education Project
   (No. 2019J1228) for funding this study.
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NR 39
TC 4
Z9 4
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0394-6320
EI 2058-7384
J9 INT J IMMUNOPATH PH
JI Int. J. Immunopathol. Pharmacol.
PD OCT
PY 2022
VL 36
AR 03946320221132712
DI 10.1177/03946320221132712
PG 13
WC Immunology; Pathology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology; Pharmacology & Pharmacy
GA 5F1JC
UT WOS:000866077700001
PM 36214213
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Peng, LH
   Xu, SY
   Shan, YH
   Wei, W
   Liu, S
   Zhang, CZ
   Wu, JH
   Liang, WQ
   Gao, JQ
AF Peng, Li-Hua
   Xu, Shen-Yao
   Shan, Ying-Hui
   Wei, Wei
   Liu, Shuai
   Zhang, Chen-Zhen
   Wu, Jia-He
   Liang, Wen-Quan
   Gao, Jian-Qing
TI Sequential release of salidroside and paeonol from a nanosphere-hydrogel
   system inhibits ultraviolet B-induced melanogenesis in guinea pig skin
SO INTERNATIONAL JOURNAL OF NANOMEDICINE
LA English
DT Article
DE nanosphere; sequential drug release; anti-melanogenesis; salidroside;
   paeonol
ID NANOSTRUCTURED LIPID CARRIERS; IN-VITRO; DRUG-DELIVERY; NANOPARTICLES;
   ACTIVATION; TYROSINASE; ACID; PIGMENTATION; INVOLVEMENT; SUPPRESSION
AB Melanin is the one of most important pigments for skin color in mammals. Excessive biosynthesis of melanin induces various pigment disorders. Much effort has been made to develop regulators to minimize skin pigmentation abnormalities. However, only a few of them are used, primarily because of safety concerns and low efficiency. In this study, we aimed to construct a novel nanosphere-gel for sequential delivery of salidroside and paeonol, to investigate the synergistic effects of these drugs in anti-melanogenesis, and to decrease their potential for toxicity in high dosage. Nanospheres were prepared and characterized for their particle size, polydispersity index, zeta potential, and morphological properties. The optimized nanospheres were incorporated in carbomer hydrogel with both paeonol and salidroside entrapped to form a dual drug-releasing nanosphere-gel. With this nanosphere-gel, rapid release of salidroside from the hydrogel followed by sustained release of paeonol from the nanosphere was achieved. Using a classical model of the melanogenesis response to ultraviolet exposure, it was shown that the anti-melanogenesis effects of the dual drug-releasing system, in which the doses of the individual drugs were decreased by half, was obviously enhanced when compared with the effects of the single drug preparations. Mechanistically, the burst release of salidroside from the hydrogel may enable prompt suppression of melanocyte proliferation on exposure to ultraviolet B radiation, while the paeonol released in a sustained manner can provide continuous inhibition of tyrosinase activity in melanocytes. Combined delivery of salidroside and paeonol was demonstrated to be a promising strategy for enhancing the therapeutic efficacy of these agents in anti-melanogenesis and reducing their toxicity, so may have great potential in nanomedicine.
C1 [Peng, Li-Hua; Xu, Shen-Yao; Shan, Ying-Hui; Wei, Wei; Liu, Shuai; Zhang, Chen-Zhen; Wu, Jia-He; Liang, Wen-Quan; Gao, Jian-Qing] Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Gao, Jian-Qing] Novel Transdermal Res Ctr Jiangsu Prov, Changzhou, Peoples R China.
C3 Zhejiang University
RP Gao, JQ (corresponding author), Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM gaojianqing@zju.edu.cn
RI Gao, Jianqing/OUJ-2930-2025; Zhang, Chenzhen/AAZ-8727-2021; wei,
   wei/IQW-1347-2023; Wu, Jiahe/D-6843-2017
OI Zhang, Chenzhen/0000-0003-0800-1908; Peng, Li-Hua/0000-0001-9763-383X;
   Wu, Jiahe/0000-0003-0080-6859
FU National Natural Science Foundation of China [81102393]; 48th China
   Postdoctoral Science Foundation [420000-X91004]; Zhejiang Provincial
   Program for the Cultivation of High-Level Innovative Health Talents;
   Fundamental Research Funds for the Central Universities, People's
   Republic of China
FX This research was supported by the National Natural Science Foundation
   of China (grant 81102393), the 48th China Postdoctoral Science
   Foundation (grant 420000-X91004), the Zhejiang Provincial Program for
   the Cultivation of High-Level Innovative Health Talents, and the
   Fundamental Research Funds for the Central Universities, People's
   Republic of China.
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NR 52
TC 37
Z9 39
U1 1
U2 89
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2013
J9 INT J NANOMED
JI Int. J. Nanomed.
PY 2014
VL 9
BP 1897
EP 1908
DI 10.2147/IJN.S59290
PG 12
WC Nanoscience & Nanotechnology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Pharmacology & Pharmacy
GA AE9TV
UT WOS:000334354100001
PM 24790432
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liao, RX
   Zhao, P
   Wu, JM
   Fang, KR
AF Liao, Rongxin
   Zhao, Peng
   Wu, Jianming
   Fang, Keren
TI Salidroside protects against intestinal barrier dysfunction in septic
   mice by regulating IL-17 to block the NF-κB and p38 MAPK signaling
   pathways
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE sepsis; salidroside; IL-17; NF-kappa B signaling pathway; p38
   mitogen-activated protein kinase signaling pathway
ID CARDIAC DYSFUNCTION; MUCOSAL BARRIER; CECAL LIGATION; UP-REGULATION;
   SEPSIS; INFLAMMATION; RATS; FIBROBLASTS; ACTIVATION; APOPTOSIS
AB Sepsis is a systemic inflammatory response syndrome, mainly caused by infection or suspected infectious factors. The intestine is not only one of the most easily involved organs in the course of sepsis, but also the dynamic organ for the course of sepsis. The present study investigated the protective effect and mechanism of salidroside on intestinal barrier dysfunction of septic mice. Briefly, C57BL/6 mice were used to establish a septic model and then administered with salidroside. The ileum tissues of mice were examined by histopathological examination. Fluorescein isothiocyanate-dextran concentration was measured. IL-17, IL-6, IL-13 and TNF-alpha levels in ileum tissues and NF-kappa B and p38 MAPK activations were detected by ELISA and the expressions of NF-kappa B p65 and p38 MAPK protein with their phosphorylation and intestinal tight junction proteins were gauged by western blotting. The above assays were performed again to investigate the effect of anti-IL-17A and salidroside (160 mg/kg) alone or in combination. The septic model induced the ileum tissue injury, increased intestinal permeability and TNF-alpha, IL-17 and IL-6 levels, activated NF-kappa B and p38 MAPK pathways, promoted the expressions of NF-kappa B p65 and p38 MAPK and their phosphorylation, while suppressing the levels of IL-13 and intestinal tight junction proteins. Salidroside and anti-IL-17A partially reversed the above effects of septic model, which in combination further strengthened the reversing effect. Collectively, salidroside protected against intestinal barrier dysfunction in septic mice by downregulating IL-17 level to inhibit NF-kappa B and p38 MAPK signaling pathways, thus providing a new treatment direction.
C1 [Liao, Rongxin; Zhao, Peng; Wu, Jianming; Fang, Keren] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Ctr Tradit Chinese Med Prevent Treatment, 13 Shiliugang Rd, Guangzhou 510310, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Liao, RX (corresponding author), Southern Med Univ, Integrated Hosp Tradit Chinese Med, Ctr Tradit Chinese Med Prevent Treatment, 13 Shiliugang Rd, Guangzhou 510310, Guangdong, Peoples R China.
EM chinalrx2021@163.com
RI Zhao, Peng/H-5901-2017
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NR 60
TC 7
Z9 10
U1 1
U2 33
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD FEB
PY 2023
VL 25
IS 2
AR 89
DI 10.3892/etm.2023.11788
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 8D3EQ
UT WOS:000918180900001
PM 36684648
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, HS
   Xi, YF
   Xin, X
   Tian, HJ
   Hu, YY
AF Li, Hongshan
   Xi, Yingfei
   Xin, Xin
   Tian, Huajie
   Hu, Yiyang
TI Salidroside improves high-fat diet-induced non-alcoholic steatohepatitis
   by regulating the gut microbiota-bile acid-farnesoid X receptor axis
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Non-alcoholic steatohepatitis; Gut microbiota; Bile acid;
   Farnesoid X receptor
ID INTESTINAL BACTERIAL OVERGROWTH; HEPATOCELLULAR-CARCINOMA;
   LIVER-DISEASE; UNITED-STATES; METABOLISM; ACTIVATION
AB Background: Our previous studies found that salidroside can effectively treat non-alcoholic steatohepatitis (NASH). Here, we discuss the mechanism of salidroside in the treatment of NASH with a focus on the gut microbiota-bile acid-farnesoid X receptor axis.
   Methods: A NASH mouse model was created by providing mice with a high-fat diet (HFD) for 14 weeks. Mice were randomly divided into the HFD group, HFD + salidroside treatment group, and HFD + obeticholic acid treatment group (n = 8 in each group) and were intragastrically administered corresponding drugs for 4 weeks. Hematoxylin-eosin staining was performed to evaluate the histopathological changes associated with the various treatments. In addition, liver triglyceride (TG) content, serum alanine aminotransferase (ALT) activity, serum inflammatory factors, gut microbiota diversity, and the bile acid profile were evaluated. Western blotting and RT-PCR were performed to detect the expressions of FXR and fibroblast growth factor 15 (FGF15).
   Results: The HFD group displayed obvious signs of hepatic steatosis. The liver TG, serum ALT, and IL-la, IL-12, MCP-1, KC, MIP-la, and MIP-113 were significantly higher in the HFD group than the control group (P < 0.01). Intestinal bacteria and bile acid profiles changed significantly in the HFD group (P < 0.05). Further, the expressions of FXR and FGF15 decreased significantly in the HFD group (P < 0.05). After treatment with salidroside, liver steatosis, TG content, and serum inflammatory factors significantly improved and HFD-induced intestinal bacteria, bile acid disorder, and FXR deficiency were significantly alleviated (P < 0.05).
   Conclusion: Salidroside can improve NASH via the gut microbiota-bile acid-FXR axis.
C1 [Li, Hongshan; Xin, Xin; Tian, Huajie; Hu, Yiyang] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai 201203, Peoples R China.
   [Li, Hongshan] Univ Chinese Acad Sci, Hwa Mei Hosp, Liver Dis Dept, Ningbo 315010, Zhejiang, Peoples R China.
   [Li, Hongshan] Key Lab Diag & Treatment Digest Syst Tumors Zheji, Ningbo 315010, Zhejiang, Peoples R China.
   [Xi, Yingfei] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Chinese Academy of
   Sciences; University of Chinese Academy of Sciences, CAS; Ningbo
   University
RP Li, HS; Hu, YY (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai 201203, Peoples R China.
EM lihongshan_1982@126.com; yyhuliver@163.com
RI xin, xin/LGY-6744-2024
FU National Natural Science Foundation of China [81873109]
FX This study was supported by grants-in-aid from the National Natural
   Science Foundation of China (81873109).
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NR 49
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Z9 58
U1 1
U2 54
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2020
VL 124
AR 109915
DI 10.1016/j.biopha.2020.109915
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KK1TS
UT WOS:000512532600037
PM 31986416
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Diab, RG
   Deeb, G
   Roda, R
   Karam, M
   Faraj, M
   Harajli, M
   Damiati, LA
   Mhanna, R
AF Diab, Rita G.
   Deeb, George
   Roda, Rena
   Karam, Mia
   Faraj, Marwa
   Harajli, Mohamad
   Damiati, Laila A.
   Mhanna, Rami
TI Maintaining the Cartilage Phenotype of Late-Passage Chondrocytes Using
   Salidroside, TGF-β, and Sulfated Alginate for Cartilage Tissue
   Engineering Applications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE cartilage; chondrocytes; alginate sulfate; Salidroside; TGF-beta; tissue
   engineering
ID EXPRESSION; DEFECTS
AB The limited self-repair capacity of cartilage due to its avascular and aneural nature leads to minimal regenerative ability. Autologous chondrocyte transplantation (ACT) is a popular treatment for cartilage defects but faces challenges due to chondrocyte dedifferentiation in later passages, which results in undesirable fibroblastic phenotypes. A promising treatment for cartilage injuries and diseases involves tissue engineering using cells (e.g., chondrocytes), scaffolds (e.g., Alginate Sulfate (AlgSulf)), and biochemical signals (e.g., Salidroside and TGF-beta). This study focuses on investigating the effects of AlgSulf scaffolds with varying degrees of sulfation, Salidroside, and TGF-beta on the proliferation, viability, and phenotype maintenance of chondrocytes. The findings demonstrate that AlgSulf films with a degree of sulfation (DS) = 2, treated with a combination of Salidroside and TGF-beta, significantly enhanced chondrocyte proliferation (p < 0.001 and p < 0.0001 in P2 and P4, respectively), preserved round cell morphology, and maintained cartilage-specific gene expression (Col2, Aggrecans, and SOX9) while downregulating fibroblastic markers (Col1, MMP13, IL-1 beta, and IL-6). Our findings suggest the potential of this combination for enhancing cartilage regeneration in tissue engineering applications.
C1 [Diab, Rita G.; Deeb, George; Roda, Rena; Karam, Mia; Faraj, Marwa; Harajli, Mohamad; Mhanna, Rami] Amer Univ Beirut, Maroun Semaan Fac Engn & Architecture, Biomed Engn Program, Beirut 11072020, Lebanon.
   [Damiati, Laila A.] Univ Jeddah, Coll Sci, Dept Biol Sci, Jeddah 21959, Saudi Arabia.
C3 American University of Beirut; University of Jeddah
RP Mhanna, R (corresponding author), Amer Univ Beirut, Maroun Semaan Fac Engn & Architecture, Biomed Engn Program, Beirut 11072020, Lebanon.; Damiati, LA (corresponding author), Univ Jeddah, Coll Sci, Dept Biol Sci, Jeddah 21959, Saudi Arabia.
EM rgd09@mail.aub.edu; gdd01@mail.aub.edu; rhr14@mail.aub.edu;
   mpk05@mail.aub.edu; mtf02@mail.aub.edu; mh135@aub.edu.lb;
   ladamiati@uj.edu.sa; rm136@aub.edu.lb
RI Damiati, Laila/H-4413-2019; Mhanna, Rami/ABH-3423-2022
OI Damiati, Laila/0000-0002-4746-0915; Karam, Mia/0000-0002-0783-3334;
   Faraj, Marwa/0009-0001-0158-9895; Mhanna, Rami/0000-0003-0345-625X
FU King Salman Center for Disability Research;  [KSRG-2023-062]
FX The authors extend their appreciation to the King Salman Center For
   Disability Research for funding this work through Research Group no.
   KSRG-2023-062.
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TC 5
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U1 0
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PU MDPI
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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PD DEC
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AR 13623
DI 10.3390/ijms252413623
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q6H8K
UT WOS:001385673700001
PM 39769386
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, CG
   Lou, YT
   Xu, JX
   Feng, ZH
   Chen, Y
   Tang, Q
   Wang, QQ
   Jin, HM
   Wu, YS
   Tian, NF
   Zhou, YF
   Xu, HZ
   Zhang, XL
AF Wang, Chenggui
   Lou, Yiting
   Xu, Jianxiang
   Feng, Zhenhua
   Chen, Yu
   Tang, Qian
   Wang, Qingqing
   Jin, Haiming
   Wu, Yaosen
   Tian, Naifeng
   Zhou, Yifei
   Xu, Huazi
   Zhang, Xiaolei
TI Endoplasmic Reticulum Stress and NF-κB Pathway in Salidroside Mediated
   Neuroprotection: Potential of Salidroside in Neurodegenerative Diseases
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Salidroside; Microglia; NF-beta B; Endoplasmic Reticulum Stress
ID NITRIC-OXIDE SYNTHASE; BRAIN INFLAMMATION; RHODIOLA-ROSEA; MICROGLIA;
   CYCLOOXYGENASE-2; INHIBITION; ACTIVATION; ENDOTOXIN; RESPONSES; EXTRACT
AB Microglial activation leads to increased production of proinflammatory enzymes and cytokines, which is considered to play crucial role in neurodegenerative diseases, however there are only a few drugs that target microglia activation. Recent studies have indicated that the Traditional Chinese Medicine, salidroside (Sal), exerted anti-inflammatory effects. According to this evidence, our present study aims to explore the effect of the Sal (a phenylpropanoid glycoside compound which is isolated from rhodiola), on microglia activation in lipopolysaccharide (LPS)-stimulated BV-2 cells. Our results showed that Sal could significantly inhibit the excessive production of Nitric Oxide (NO) and Prostaglandin E2 (PGE2) in LPS-stimulated BV2 cells. Moreover, Sal treatment could suppress the mRNA and protein expressions of inflammatory enzymes, including Inducible Nitric Oxide Synthase (iNOS) and Cyclooxygenase-2 (COX-2). The mechanisms may be related to the inhibition of the activation of Nuclear Factor-kappaB (NF-kappa B) and endoplasmic reticulum stress. Our study demonstrated that salidroside could inhibit lipopolysaccharide-induced microglia activation via the inhibition of the NF-kappa B pathway and endoplasmic reticulum stress, which makes it a promising therapeutic agent for human neurodegenerative diseases.
C1 [Wang, Chenggui; Lou, Yiting; Xu, Jianxiang; Feng, Zhenhua; Chen, Yu; Tang, Qian; Wang, Qingqing; Jin, Haiming; Wu, Yaosen; Tian, Naifeng; Zhou, Yifei; Xu, Huazi; Zhang, Xiaolei] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, 109 XueYuan Rd West, Wenzhou 325000, Zhejiang, Peoples R China.
   [Wang, Chenggui; Lou, Yiting; Xu, Jianxiang; Feng, Zhenhua; Chen, Yu; Tang, Qian; Wang, Qingqing; Jin, Haiming; Wu, Yaosen; Tian, Naifeng; Zhou, Yifei; Xu, Huazi; Zhang, Xiaolei] Wenzhou Med Univ, Yuying Childrens Hosp, 109 XueYuan Rd West, Wenzhou 325000, Zhejiang, Peoples R China.
   [Wang, Chenggui; Lou, Yiting; Xu, Jianxiang; Feng, Zhenhua; Chen, Yu; Tang, Qian; Wang, Qingqing; Jin, Haiming; Wu, Yaosen; Tian, Naifeng; Zhou, Yifei; Xu, Huazi; Zhang, Xiaolei] Key Lab Orthopaed Zhejiang Prov, Wenzhou 325000, Peoples R China.
   [Zhang, Xiaolei] Chinese Orthopaed Regenerat Med Soc, Hangzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Xu, HZ; Zhang, XL (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, 109 XueYuan Rd West, Wenzhou 325000, Zhejiang, Peoples R China.; Xu, HZ; Zhang, XL (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, 109 XueYuan Rd West, Wenzhou 325000, Zhejiang, Peoples R China.
EM spinexu@163.com; zhangxiaolei@wmu.edu.cn
RI XU, JIANXIANG/HCH-2510-2022; Zhang, Xiaolei/AFS-0882-2022; Wang,
   Chenggui/PMR-3500-2026; Jin, Haiming/LZE-3453-2025
OI Zhang, Xiaolei/0000-0003-0117-7599; Wang, Chenggui/0000-0002-0512-784X;
   Jin, Haiming/0000-0003-2666-8415
FU National Natural Science Foundation of China [81401871, 81401162,
   81572227]; Zhejiang Provincial Natural Science Foundation of China
   [LY17H060010, LY14H170002]
FX This study was supported by National Natural Science Foundation of China
   (81401871, 81401162 and 81572227), Zhejiang Provincial Natural Science
   Foundation of China (LY17H060010 and LY14H170002).
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NR 37
TC 17
Z9 19
U1 1
U2 21
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2017
VL 45
IS 7
BP 1459
EP 1475
DI 10.1142/S0192415X17500793
PG 17
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA FJ8RB
UT WOS:000413035200007
PM 28946765
DA 2026-05-27
ER

PT J
AU Wang, Q
   Wei, X
   Liao, KJ
   Li, H
   Meng, XB
   Li, ZJ
AF Wang, Qing
   Wei, Xiong
   Liao, Kaijun
   Li, Hui
   Meng, Xiangbao
   Li, Zhongjun
TI A convenient preparation of glycosyl sulfoxides and its application to
   the synthesis of Salidroside epimer
SO TETRAHEDRON LETTERS
LA English
DT Article
DE Glycosyl sulfoxides; Aqueous H2O2; Oxidation; 1,2-cis glycosidic bond;
   Salidroside epimer
ID BETA-MANNOPYRANOSIDES; ANOMERIC SULFOXIDES; VERSATILE REAGENTS;
   HYDROGEN-PEROXIDE; SULFIDES; OXIDATION; EFFICIENT; DONORS; COMPLETION;
   ACTIVATION
AB A facile and green approach for the preparation of glycosyl sulfoxides utilizing 30% aqueous H2O2 in phenol or acetic acid is described. Advantages include relatively mild conditions, high chemoselectivity, and good tolerance to a wide range of protective groups. Furthermore, the epimer of Salidroside containing one 1,2-cis glycosidic bond was synthesized in three steps in 90.1% overall yield using glucopyranosyl sulfoxide as the glycosyl donor. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Wang, Qing; Wei, Xiong; Liao, Kaijun; Li, Hui; Meng, Xiangbao; Li, Zhongjun] Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
C3 Peking University
RP Li, ZJ (corresponding author), Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
RI Meng, Xiangbao/HHD-3573-2022; Wei, Xiong/GRO-6843-2022
OI Meng, Xiangbao/0000-0003-3418-9975; 
FU National Basic Research Program of China [2012CB822100]; National
   Natural Science Foundation of China (NSFC) [21072017, 21072016,
   20972012]
FX This work was supported by grants from the National Basic Research
   Program of China (Grant No. 2012CB822100) and the National Natural
   Science Foundation of China (NSFC No. 21072017, 21072016, 20972012).
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NR 32
TC 5
Z9 8
U1 1
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0040-4039
J9 TETRAHEDRON LETT
JI Tetrahedron Lett.
PD MAY 25
PY 2016
VL 57
IS 21
BP 2277
EP 2279
DI 10.1016/j.tetlet.2016.04.045
PG 3
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC); Current Chemical Reactions (CCR-EXPANDED)
SC Chemistry
GA DM2XV
UT WOS:000376212300017
DA 2026-05-27
ER

PT J
AU Wang, J
   Zhu, Q
   Chan, PR
   Zhu, ZY
   Zheng, MM
   Mao, ZY
   Gu, MF
   Ren, ZJ
   Cui, M
   Liu, J
   Zhang, YJ
AF Wang, Juan
   Zhu, Qian
   Chan, Peiran
   Zhu, Ziyan
   Zheng, Mingming
   Mao, Zhiyuan
   Gu, Mufeng
   Ren, Zijian
   Cui, Min
   Liu, Jie
   Zhang, Yongjie
TI Salidroside-Pretreated Small Extracellular Vesicles Derived from Human
   Umbilical Cord Mesenchymal Stem Cells Promote Blood-Spinal Cord Barrier
   Repair After Spinal Cord Injury in Mice
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Spinal cord injury; Salidroside; Small extracellular vesicles;
   Blood-spinal cord barrier
ID CENTRAL-NERVOUS-SYSTEM; MICROGLIA
AB This study investigates the role of salidroside-pretreated small extracellular vesicles (SAL-sEVs) derived from human umbilical cord mesenchymal stem cells (Huc-MSCs) in spinal cord injury (SCI). Results demonstrate that these sEVs repair the damaged blood-spinal cord barrier (BSCB) and facilitate functional recovery. sEVs were collected from Huc-MSCs pretreated with salidroside via ultracentrifugation. sEVs were characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blot. The uptake of sEVs by endothelial cells was confirmed through immunofluorescence. The regulatory effects of SAL-sEVs on BSCB permeability and tight junction proteins were examined using immunofluorescence and Western blot. Microglial polarization was assessed via ELISA, qRT-PCR, and Western blot. Motor function was evaluated through behavioral tests. SAL-sEVs were endocytosed by endothelial cells, reduced BSCB permeability by regulating tight junction proteins, alleviated secondary inflammation, facilitated repair of spinal cord injury sites, and improved motor function in mice. Salidroside augments the therapeutic promise of Huc-MSC-derived small extracellular vesicles in repairing the BSCB, inflammation reduction, and functional recovery post-SCI, offering a novel therapeutic approach for the treatment of SCI.
C1 [Wang, Juan; Zhu, Qian; Chan, Peiran; Zhu, Ziyan; Zheng, Mingming; Mao, Zhiyuan; Gu, Mufeng; Ren, Zijian; Cui, Min; Zhang, Yongjie] Nanjing Med Univ, Sch Basic Med, Dept Human Anat, Nanjing, Jiangsu, Peoples R China.
   [Liu, Jie] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Sch Clin Med, Dept Orthoped, Nanjing, Peoples R China.
   [Cui, Min] Nanjing Med Univ, Natl Demonstrat Ctr Expt Basic Med Educ, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University
RP Cui, M; Zhang, YJ (corresponding author), Nanjing Med Univ, Sch Basic Med, Dept Human Anat, Nanjing, Jiangsu, Peoples R China.; Liu, J (corresponding author), Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Sch Clin Med, Dept Orthoped, Nanjing, Peoples R China.; Cui, M (corresponding author), Nanjing Med Univ, Natl Demonstrat Ctr Expt Basic Med Educ, Nanjing, Jiangsu, Peoples R China.
EM mincui0228@njmu.edu.cn; zx123020@163.com; zhangyongjie@njmu.edu.cn
FU (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) [81472081, 81100942]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81472081, 81100942).
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NR 45
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD NOV 19
PY 2025
VL 63
IS 1
AR 89
DI 10.1007/s12035-025-05410-6
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9YQ6V
UT WOS:001618157800001
PM 41261280
DA 2026-05-27
ER

PT J
AU Wang, F
   Huang, DF
   Ma, Y
   Zhang, FM
   Linhardt, RJ
AF Wang, Feng
   Huang, Dengfa
   Ma, Yong
   Zhang, Fuming
   Linhardt, Robert J.
TI Preparation of salidroside with n-butyl -D-glucoside as the
   glycone donor via a two-step enzymatic synthesis catalyzed by
   immobilized -glucosidase from bitter almonds
SO BIOCATALYSIS AND BIOTRANSFORMATION
LA English
DT Article
DE Salidroside; two-step enzymatic synthesis; immobilized -glucosidase;
   n-butyl--D-glucoside; selectivity
ID BETA-D-GLUCOPYRANOSIDES; APPLE SEED MEAL; COVALENT IMMOBILIZATION;
   OPTIMIZATION; PURIFICATION; GLYCOSIDES; ALCOHOLS; ENZYMES;
   GLUCOSYLATION; BIOCATALYSIS
AB beta-Glucosidase from bitter almonds was immobilized on epoxy group-functionalized beads for catalyzing salidroside synthesis in a two-step process with n-butyl--D-glucoside (BG) as the glucosyl donor. The formation of salidroside ((0.59 +/- 0.02) M) at a yield of 39.04%+/- 1.25% was accomplished in 8h by the transglucosylation of immobilized -glucosidase at pH8.0 and 50 degrees C when the ratio of BG to tyrosol was 1:2 (mol/mol). A study on the influence of different glycosyl acceptors demonstrated that the yield of the glucosylation reaction of phenylmethanol and cyclohexanol was higher than that of either phenol or cyclohexanol. This may account for the selectivity of the immobilized enzyme towards the alcoholic hydroxyl group of tyrosol in the salidroside synthesis reaction. A study on the synthesis of BG via the reverse hydrolysis of immobilized -glucosidase showed that a yield of 78.04%+/- 2.2% BG can be obtained with a product concentration of (0.23 +/- 0.015) M.
C1 [Wang, Feng; Huang, Dengfa; Ma, Yong] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Jiangsu, Peoples R China.
   [Wang, Feng] Jiangnan Univ, Minist Educ, Key Lab Food Colloids & Biotechnol, Wuxi, Jiangsu, Peoples R China.
   [Zhang, Fuming; Linhardt, Robert J.] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Biol Engn, Dept Chem & Chem Biol,Biol & Biomed Engn, Troy, NY USA.
C3 Jiangnan University; Jiangnan University; Rensselaer Polytechnic
   Institute
RP Wang, F (corresponding author), Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Jiangsu, Peoples R China.
EM fwang@jiangnan.edu.cn
OI wang, feng/0000-0002-0482-3720
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NR 63
TC 7
Z9 7
U1 3
U2 49
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1024-2422
EI 1029-2446
J9 BIOCATAL BIOTRANSFOR
JI Biocatal. Biotransform.
PD JUL 4
PY 2019
VL 37
IS 4
BP 246
EP 260
DI 10.1080/10242422.2018.1549236
PG 15
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA HZ7HW
UT WOS:000469025700002
DA 2026-05-27
ER

PT J
AU He, L
   Xiao, SS
   Wang, XD
   Qin, JG
   Chen, LQ
   Li, ER
AF He, Long
   Xiao, Shusheng
   Wang, Xiaodan
   Qin, Jianguang
   Chen, Liqiao
   Li, Erchao
TI Dietary salidroside and astragalus polysaccharides enhance the growth
   performance and hypoxia tolerance of juvenile Chinese mitten crabs
   (Eriocheir sinensis)
SO AQUACULTURE
LA English
DT Article
DE Eriocheir sinensis; Salidroside; Astragalus polysaccharides; Growth
   performance; Hypoxia tolerance
ID BLUE-CRAB; RESPONSES; STRESS
AB This study investigates the effects of salidroside and astragalus polysaccharides on growth performance and hypoxia tolerance of juvenile Chinese mitten crabs (Eriocheir sinensis). A total of 1200 crabs (0.23 +/- 0.01 g) were randomly allocated to 5 groups, each with 6 replicates of 40 crabs. Crabs were fed isonitrogenous and isolipidic diets containing 0 (control), 300 or 600 mg/kg salidroside (S300 or S600), 300 or 600 mg/kg astragalus polysaccharides (A300 or A600) for 8 weeks. After feeding trial, each group underwent a 24-h hypoxia stress with dissolved oxygen maintained at 2.0 +/- 0.2 mg/L. The weight gain of A600 group has significantly increased. Hypoxia significantly reduced the oxygen consumption rate and hemocyanin content. In contrast, S300 group exhibited a significant increase in hemocyanin content, whereas A600 group showed a significant decrease in oxygen consumption rate. S300 group showed significant increases in glycogen content and cpt1 expression, whereas lactic acid and triglyceride contents significantly decreased. Supplementation with 600 mg/kg astragalus polysaccharides reduced glycogen and triglyceride contents at different oxygen levels. Salidroside significantly reduced malondialdehyde content, it also increased glutathione peroxidase and superoxide dismutase activities. Under hypoxia, only A600 group increased alkaline and acid phosphatase activities compared to the control group. Thus, salidroside and astragalus polysaccharides effectively increased hypoxia tolerance by reducing the oxygen consumption rate, improving energy metabolism, strengthening antioxidant capacity and regulating immune responses. Based on these findings, dietary supplementation with 300 mg/kg salidroside or 600 mg/kg astragalus polysaccharides is recommended to improve crab growth performance and hypoxia tolerance.
C1 [He, Long; Xiao, Shusheng; Wang, Xiaodan; Chen, Liqiao; Li, Erchao] East China Normal Univ, Sch Life Sci, Lab Aquaculture Nutr & Environm Hlth, 500 Dongchuan Rd, Shanghai 200241, Peoples R China.
   [Qin, Jianguang] Flinders Univ S Australia, Coll Sci & Engn, Adelaide, SA 5001, Australia.
C3 East China Normal University; Flinders University
RP Chen, LQ; Li, ER (corresponding author), East China Normal Univ, Sch Life Sci, Lab Aquaculture Nutr & Environm Hlth, 500 Dongchuan Rd, Shanghai 200241, Peoples R China.
EM lqchen@bio.ecnu.edu.cn; ecli@bio.ecnu.edu.cn
FU National Key Research and Development Program of China [2023YFD2402000];
   Agriculture Research System of Shanghai, China [202504]; Agriculture
   Research System of China of MOF and MARA [CARS-48]
FX This work was supported by grants from the National Key Research and
   Development Program of China (2023YFD2402000) , the Agriculture Research
   System of Shanghai, China (202504) , and the Agriculture Research System
   of China of MOF and MARA (CARS-48) .
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NR 50
TC 1
Z9 1
U1 17
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0044-8486
EI 1873-5622
J9 AQUACULTURE
JI Aquaculture
PD JAN 15
PY 2026
VL 612
AR 743216
DI 10.1016/j.aquaculture.2025.743216
EA SEP 2025
PN 1
PG 10
WC Fisheries; Marine & Freshwater Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Fisheries; Marine & Freshwater Biology
GA 7VR5X
UT WOS:001580769100001
DA 2026-05-27
ER

PT J
AU Wang, IL
   Su, Y
   Zhang, L
   Tang, MB
   Chen, YM
AF Wang, I-Lin
   Su, Yu
   Zhang, Long
   Tang, Maobing
   Chen, Yi-Ming
TI Combined Rhodiola rosea and eccentric training boost endurance
   performance and lower-limb reactive strength in recreationally active
   women
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE eccentric fly-wheel training (ECC); salidroside supplementation;
   reactive strength index (RSI); muscle-damage biomarkers; endurance
   performance
ID MUSCLE DAMAGE; RESISTANCE EXERCISE; EXTRACT; STRESS; HYPERTROPHY;
   SALIDROSIDE; ADAPTATIONS; ACTIVATION; MECHANISMS; OVERLOAD
AB This study aimed to determine whether chronic Rhodiola rosea (salidroside) supplementation augments neuromuscular and metabolic adaptations to flywheel eccentric (ECC) training. In total, 30 recreationally active female students were randomly assigned to (1) sedentary placebo control (SC, n = 10), (2) ECC training + placebo (ECC, n = 10), or (3) ECC training + salidroside (150 mg day-1; ECC + SA, n = 10) for 4 weeks. Pre- and post-intervention assessments included exhaustive cycling time to volitional fatigue, peak oxygen uptake (VO2 max), drop vertical jump (DJ) reactive strength index (RSI), and blood biomarkers of muscle damage and metabolism. ECC and ECC + SA prolonged time to exhaustion by 33% and 45%, respectively, without altering VO2 max. Across DJ1-DJ160, RSI significantly increased in both ECC groups (p < 0.01). Salidroside conferred an additional 8%-33% RSI advantage during the final 40 contacts (DJ120-DJ160; p < 0.05). The ECC + SA group exhibited lower postcycling creatine kinase (CK) and higher free fatty acids (FFA) than the SC group (p < 0.05). Triacylglycerol and low-density lipoprotein cholesterol decreased in ECC + SA compared with SC (p < 0.05), whereas body composition remained unchanged. In conclusion, four weeks of ECC training improved endurance and stretch-shortening performance. Salidroside further enhanced late-stage RSI, with additive antifatigue and muscle-protective effects during high-load eccentric conditioning in recreationally active women.
C1 [Wang, I-Lin; Zhang, Long] Liupanshui Normal Univ, Sch Phys Educ, Liupanshui, Guizhou, Peoples R China.
   [Su, Yu] Hebei Gen Hosp, Hebei Rehabil Ctr, Shijiazhuang, Hebei, Peoples R China.
   [Tang, Maobing] Tarim Inst Technol, Dept Basic Educ, Alaer, Xinjiang, Peoples R China.
   [Chen, Yi-Ming] Fu Jen Catholic Univ, Dept Food Sci, New Taipei City, Taiwan.
   [Chen, Yi-Ming] Fu Jen Catholic Univ, PhD Program Nutr & Food Sci, New Taipei City, Taiwan.
C3 Liupanshui Normal University; Fu Jen Catholic University; Fu Jen
   Catholic University
RP Chen, YM (corresponding author), Fu Jen Catholic Univ, Dept Food Sci, New Taipei City, Taiwan.; Chen, YM (corresponding author), Fu Jen Catholic Univ, PhD Program Nutr & Food Sci, New Taipei City, Taiwan.
EM 155429@mail.fju.edu.tw
RI Chen, Yi-Ming/Y-7912-2018; Wang, I-Lin/AAZ-9506-2021
OI Chen, Yi-Ming/0000-0003-2914-6751; Wang, I-Lin/0000-0002-6234-3768
FU Ministry of Science and Technology, Taiwan10.13039/501100004663;
   Ministry of Science and Technology of Taiwan [113-2320-B-030-004]; NSTC
   [LPSSYylzy2301]; First-class undergraduate professional construction
   project
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   Ministry of Science and Technology of Taiwan (grant no. NSTC
   113-2320-B-030-004) and First-class undergraduate professional
   construction project approve [grant number LPSSYylzy2301].
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NR 42
TC 0
Z9 0
U1 3
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 8
PY 2025
VL 16
AR 1663086
DI 10.3389/fphys.2025.1663086
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 7PT9X
UT WOS:001576765700001
PM 40988719
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, SY
   Chen, HY
AF Liu, Shuyuan
   Chen, Haoyu
TI Mechanism of Nardostachyos Radix et Rhizoma-Salidroside in the treatment
   of premature ventricular beats based on network pharmacology and
   molecular docking
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIAC-HYPERTROPHY; HEART; PROTECTS; AKT; ACCUMULATION; INFLAMMATION;
   CONTRIBUTES; PREDICTION
AB To analyse the mechanism of Nardostachyos Radix et Rhizoma-Salidroside in the treatment of Premature Ventricular Brats by using network pharmacology and molecular docking and to provide the basis for developing the use of experimental and clinical traditional Chinese medicine. The chemical compositions of Nardostachyos Radix et Rhizoma and Salidroside were determined, and their related targets were predicted. The disease-related targets were obtained by searching the common disease databases Genecards, OMIM, Drugbank and DisGeNET, and the intersection between the predicted targets and the disease targets was determined. Then using the STRING database to set up the protein-protein interactions (PPIs) network between Nardostachyos Radix et Rhizoma-Salidroside and the common targets of PVB. An "herb-ingredient-target" network was constructed and analyzed by Cytoscape3.7.2 software. Using the metascape database to analysis the predicted therapeutic targets based on the GO and KEGG. Finally, molecular docking technology was used toconfirm the capacity of the primary active ingredients of the 2 herbs to bind to central targets using the online CB-Dock2 database. 41 active components of Nardostachyos Radix et Rhizoma-Salidroside were detected, with 420 potential targets of action, with a total of 1688 PVB targets, and the top 10 core targets of herb-disease degree values were AKT1, TNF, GAPDH, SRC, PPARG, EGFR, PTGS2, ESR1, MMP9, and STAT3. KEGG analysis indicated that its mechanism may be related to the calcium signalling pathway, cancer signalling pathway, AGE-RAGE signalling pathway and other pathways. Molecular docking suggested that main of the active ingredients of the Nardostachyos Radix et Rhizoma-Salidroside pairs were well bound to the core targets. Based on novel network pharmacology and molecular docking validation research methods, we revealed for the first time the potential mechanism of Nardostachyos Radix et Rhizoma-Salidroside in PVB therapy.
C1 [Liu, Shuyuan] Shandong Univ Tradit Chinese Med, Clin Med Sch 1, Jinan 250013, Shandong, Peoples R China.
   [Chen, Haoyu] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Cardiol, Jinan 250011, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Chen, HY (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Cardiol, Jinan 250011, Shandong, Peoples R China.
EM chenhaoyu0520@163.com
RI Chen, Haoyu/JOK-4487-2023
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NR 59
TC 12
Z9 12
U1 1
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 25
PY 2023
VL 13
IS 1
AR 20741
DI 10.1038/s41598-023-48277-0
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AH3V5
UT WOS:001117544000043
PM 38007574
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mao, GX
   Xing, WM
   Wen, XL
   Jia, BB
   Yang, ZX
   Wang, YZ
   Jin, XQ
   Wang, GF
   Yan, J
AF Mao, G. -X.
   Xing, W. -M.
   Wen, X. -L.
   Jia, B. -B.
   Yang, Z. -X.
   Wang, Y. -Z.
   Jin, X. -Q.
   Wang, G. -F.
   Yan, J.
TI Salidroside protects against premature senescence induced by ultraviolet
   B irradiation in human dermal fibroblasts
SO INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
LA English
DT Article
DE cell culture; delivery; vectorization; penetration; salidroside;
   senescence; skin physiology; structure
ID HUMAN SKIN FIBROBLASTS; IN-VIVO; CELLULAR SENESCENCE; OXIDATIVE STRESS;
   CULTURED-CELLS; UVB; MECHANISMS; EXPRESSION; PHOTODAMAGE; COMPONENT
AB Synopsis
   ObjectivesSalidroside, the predominant component of a Chinese herbal medicine, Rhodiola rosea L., becomes an attractive bio-agent due to its multifunction. Although it is well proposed that this herbal medicine may have photoprotective effect according to the folk hearsay, the direct supportive experimental evidences linking the drug with skin ageing have rarely been reported so far. The study was conducted to investigate the photoprotective role of salidrosdie and its related mechanisms in vitro.
   MethodsFirst, a premature senescence model induced by UVB irradiation (250mJ cm(-2)) in human dermal fibroblasts (HDFs) was established, and senescent phenotypes were evaluated by cell morphology, cell proliferation, senescence-associated beta-galactosidase (SA--gal) activity and cell cycle distribution. Then the photoprotective effect of salidroside was investigated. Cells were pre-treated with various doses of salidroside (1, 5 and 10M) followed by the sublethal dosage of UVB exposure and then were harvested for various detections, including senescence-associated phenotypes and molecules, alteration of oxidative stress, matrix metalloproteinase-1 (MMP-1) secretion and inflammatory response.
   ResultsPre-treatment of salidroside dose dependently reversed the senescent state of HDFs induced by UVB as evidenced by elevated cell viability, decreased SA--gal activity and relieving of G1/G0 cell cycle arrest. UVB-induced increased protein expression of cyclin-dependent kinase (CDK) inhibitors p21(WAF1) and p16(INK4) was also repressed by salidrosdie treatment in a dose-dependent manner. Meanwhile, the increment of malondialdehyde (MDA) level in UVB-irradiated HDFs was inhibited upon salidroside treatment. Additionally, salidroside significantly attenuated UVB-induced synthesis of MMP-1 as well as the production of IL-6 and TNF- in HDFs.
   ConclusionOur data provided the evidences for the protective role of salidroside against UVB-induced premature senescence in HDFs probably via its anti-oxidative property and inhibition on production of MMP-1 and pro-inflammatory cytokines, which indicated its potential utilization as an active ingredient in the preparation of photoprotective formulation.
   Resume
   ObjectifsSalidroside, le compose predominant de une plante medicinale chinoise, Rhodiola rosea L., pourrait etre un agent biologique attractif en raison de sa multifonctionalite. Bien que ce medicament a base de plantes puisse avoir un effet de photo-protection selon l'oui-dire populaire, les preuves experimentales directes reliant le medicament au vieillissement de la peau ont ete rarement rapportees jusqu'ici. L'etude a ete menee pour etudier le role de photo-protection de salidroside et ses mecanismes connexes in vitro.
   MethodesD'abord, un modele de senescence prematuree induite par l'irradiation UVB (250mJ cm(-2)) dans les fibroblastes dermiques humains (HDFS) a ete cree et des phenotypes senescentes ont ete evaluee par la morphologie cellulaire, la proliferation cellulaire, l'activite beta-galactosidase (SA-- gal) associee a la senescence et la distribution du cycle cellulaire. Ensuite, on a etudie l'effet photo-protecteur de salidroside. Les cellules ont ete pretraitees avec diverses doses de salidroside (1, 5, 10M), suivie par la dose sous-letale de l'exposition aux UVB et puis ont ete recoltees pour differentes analyses, y compris des phenotypes et des molecules associes a la senescence, l'alteration du stress oxydatif, la secretion de la metalloproteinase matricielle -1 (MMP-1) et la reponse inflammatoire.
   ResultatsLe pretraitement au salidroside inverse l'etat de senescence des HDFS induits par les UVB de maniere dose-dependante comme en temoigne la viabilite cellulaire elevee, la diminution de l'activite -SA-gal, et de relaxation de l'arret du cycle cellulaire de G1/G0. L'expression augmentee des inhibiteurs proteine-kinase cycline-dependantes (CDK)p21WAF1 et p16INK4 induites par les UVB est egalement reprimee par le traitement au salidroside d'une maniere dependant de la dose. Pendant ce temps, l'augmentation du niveau de malondialdehyde (MDA) dans les HDFs UVB-irradies a ete inhibee par le traitement au salidroside. En outre, salidroside attenue significativement la synthese de MMP-1 induite par UVB, ainsi que la production d'IL-6 et TNF- dans HDFs.
   ConclusionNos donnees fournisssent les preuves pour le role de protection du salidroside contre la senescence prematuree induite par les rayons UVB dans les HDFs, probablement via sa propriete anti-oxydante et l'inhibition de la production de MMP-1 et des cytokines pro-inflammatoires, ce qui indique son utilisation potentielle en tant qu'ingredient actif dans la preparation d'une formulation de photo-protection.
C1 [Mao, G. -X.; Xing, W. -M.; Wen, X. -L.; Jia, B. -B.; Yang, Z. -X.; Wang, Y. -Z.; Jin, X. -Q.; Wang, G. -F.; Yan, J.] Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
   [Mao, G. -X.; Xing, W. -M.; Wen, X. -L.; Jia, B. -B.; Yang, Z. -X.; Wang, Y. -Z.; Jin, X. -Q.; Wang, G. -F.; Yan, J.] Zhejiang Hosp, Geriatr Res Inst Zhejiang Prov, Hangzhou 310013, Zhejiang, Peoples R China.
   [Yan, J.] Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Wang, GF (corresponding author), Zhejiang Hosp, 12 Lingyin Rd, Hangzhou 310013, Zhejiang, Peoples R China.
EM zpklg@aliyun.com; zjicu@vip.163.com
FU National Natural Science Foundation of China [31201040, 31301139];
   Ministry of Health of China [WKJ2011-2-014]; Health Bureau of Zhejiang
   Province [2013KYA003]; Zhejiang Provincial Administration of Traditional
   Chinese Medicine [2012-XK-A04]
FX This work was supported by funds from the National Natural Science
   Foundation of China (31201040 and 31301139) and funds from Ministry of
   Health of China (WKJ2011-2-014), Health Bureau of Zhejiang Province
   (2013KYA003) and Zhejiang Provincial Administration of Traditional
   Chinese Medicine (2012-XK-A04).
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NR 43
TC 43
Z9 48
U1 1
U2 72
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0142-5463
EI 1468-2494
J9 INT J COSMETIC SCI
JI Int. J. Cosmetic Sci.
PD JUN
PY 2015
VL 37
IS 3
BP 321
EP 328
DI 10.1111/ics.12202
PG 8
WC Chemistry, Applied; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Dermatology
GA CH7JC
UT WOS:000354211200009
PM 25639473
DA 2026-05-27
ER

PT J
AU Recio, MC
   Giner, RM
   Máñez, S
AF Recio, Mari-Carmen
   Giner, Rosa-Maria
   Manez, Salvador
TI Immunmodulatory and Antiproliferative Properties of Rhodiola
   Species
SO PLANTA MEDICA
LA English
DT Review
DE Rhodiola; salidroside; adaptatogen; antitumor; immunostimulant;
   antioxidant
ID AQUEOUS EXTRACT; IMMUNE-RESPONSE; COLON-CANCER; CELL-DEATH; ROSEA-L.;
   SALIDROSIDE; CRENULATA; PROLIFERATION; APOPTOSIS; IMBRICATA
AB The traditional medicines of Asia and Europe have long used various Rhodiola species, which are endemic to the subarctic areas of the northern hemisphere, as tonic, adaptogen, antidepressant, and anti-inflammatory drugs. In order to establish the therapeutic uses of these plants in modern medicine, the pharmacological effects of Rhodiola sp. have been widely studied. Indeed, the most amply researched species, Rhodiola rosea, has been shown to possess antioxidant, adaptogenic, antistress, antimicrobial, immunomodulatory, angiomodulatory, and antitumoral effects. Salidroside (p-hydroxyphenethyl-beta-D-glucoside), a major compound in Rhodiola, seems to be responsible for many of the effects observed with Rhodiola extracts.
   The aim of this paper is to review the pharmacological effects not only of various Rhodiola species, mainly R. rosea along with Rhodiola imbricata, Rhodiola algida, and Rhodiola crenulata, but also of salidroside, focusing especially on its antioxidant, immunomodulatory, antitumoral, and antiproliferative activities, as well as to describe their therapeutic significance in disease management. Although previous pharmacological studies have established a scientific basis for possible therapeutic uses of Rhodiola extracts and salidroside, high-quality, randomized, controlled clinical trials are still needed.
C1 [Recio, Mari-Carmen; Giner, Rosa-Maria; Manez, Salvador] Univ Valencia, Fac Pharm, Dept Pharmacol, Valencia, Spain.
C3 University of Valencia
RP Recio, MC (corresponding author), Univ Valencia, Fac Pharm, Dept Pharmacol, Avda Vicent Andres Estelles S-N, E-46100 Burjassot, Valencia, Spain.
EM maria.c.recio@uv.es
RI Giner, RM/AAP-1773-2020; /H-6200-2015
OI Giner, RM/0000-0001-5455-5923; MCarmen, Recio/0000-0002-0933-2306
CR [Anonymous], EMAHMPC2321002011
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NR 60
TC 47
Z9 52
U1 4
U2 91
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD JUL
PY 2016
VL 82
IS 11-12
BP 952
EP 960
DI 10.1055/s-0042-107254
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DS0MO
UT WOS:000380290900005
PM 27224273
OA Bronze
DA 2026-05-27
ER

PT J
AU Wang, ML
   Guo, CX
AF Wang Mengliang
   Guo Chunxia
TI Biocatalytic Synthesis of Salidroside by β-Glucosidase in Ionic Liquids
SO CHINESE JOURNAL OF CATALYSIS
LA Chinese
DT Article
DE ionic liquid; beta-glucosidase; salidroside; biocatalysis; tyrosol
ID ENZYMATIC-SYNTHESIS; GLUCOSYLATION; TYROSOL; LIPASE
AB beta-Glucosidase modified with polyethylene glycol (PEG) was used as catalyst for the synthesis of salidroside from tyrosol and D-glucose, and its catalytic activity in three ionic liquids, [bmim]PF6, [bmim]BF4, and [bmim]Tf2N, and two common organic solvents, 1,4-dioxane and n-hexane, was measured. Ionic liquid [bmim]PF6 was the optimal reaction medium, and different reaction conditions were optimized in it. A yield of 88.5% (product content of 61.93 mmol/L) was obtained under the conditions of H2O content of 2%, temperature of 50 degrees C, tyrosol content of 70 mmol/L, D-glucose/tyrosol molar ratio of 2, and reaction time of 24 h. The results suggest that both the modification with PEG and using ionic liquid [bmim]PF6 as reaction medium have obvious promoting effects on the enzymatic synthesis of salidroside.
C1 [Wang Mengliang; Guo Chunxia] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China.
C3 Shanxi University
RP Wang, ML (corresponding author), Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China.
EM mlwang@sxu.edu.cn
FU Construction of Catalytic Technology Platform in Shanxi Province
   [2008091001]
FX This work was supported by the Construction of Catalytic Technology
   Platform in Shanxi Province (2008091001).
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NR 18
TC 4
Z9 6
U1 0
U2 37
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 0253-9837
EI 1872-2067
J9 CHINESE J CATAL
JI Chin. J. Catal.
PD JUN
PY 2011
VL 32
IS 6
BP 1051
EP 1055
DI 10.3724/SP.J.1088.2011.01211
PG 5
WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA 788EU
UT WOS:000292429000024
DA 2026-05-27
ER

PT J
AU Huang, WY
   Li, LJ
   Hu, DC
   Wu, MY
   Gao, WY
   Lai, YB
   Li, YQ
AF Huang, Wen-Yi
   Li, Li-Jun
   Hu, Da-Chun
   Wu, Mei-Yan
   Gao, Wen-Yan
   Lai, Ying-Biao
   Li, Yan-Qing
TI Separation and Determination of Salidroside, Caffeic Acid and Gallic
   Acid in Rhodiola L. by Large-Volume Sample
   Stacking-Sweeping-Micellar Electrokinetic Chromatography
SO ASIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Micellar electrokinetic chromatography; Electrostacking; Large volume
   sample stacking; Sweeping; Salidroside; Caffeic acid; Gallic acid
ID CAPILLARY-ELECTROPHORESIS; PRECONCENTRATION
AB In this study, a new method for simultaneous determination of salidroside, caffeic acid and gallic acid in Rhodiola L. by large volume sample stacking-Sweeping micellar electrokinetic chromatography (LVSS-sweeping-MEKC) has been proposed. The determination conditions containing pH in background solution, concentrations of Na2B4O7, sodium dodecyl sulfate (SDS) and acetonitrile, injection time, negative voltage and separation voltage were optimized. The operating buffer was composed of 20 mmol/L Na2B4O7, 80 mmol/L sodium dodecyl sulfate and 10 % (by volume) acetonitrile at pH 9.7 with a constant temperature of 25 degrees C. The UV detection wavelength was 213 nm, the reverse voltage was -8 kV, separation voltage was 20 kV and injection time was 120 s. The linear ranges of the method were 13.1-49.6 mu g/L for salidroside, 1.0-15.7 mu g/L for caffeic acid and 1.1-18.2 mu g/L for gallic acid. The recoveries were 95-106, 98-112 and 91-108 %, respectively. The RSDs of peak area were less than 4 % and detection limits (S/N = 3) were 194, 28 and 29 mu g/L for salidroside, caffeic acid and gallic acid respectively.
C1 [Huang, Wen-Yi; Li, Li-Jun; Hu, Da-Chun; Wu, Mei-Yan; Lai, Ying-Biao; Li, Yan-Qing] Guangxi Univ Technol, Dept Biol & Chem Engn, Liuzhou 545006, Guangxi, Peoples R China.
   [Gao, Wen-Yan] Guangxi Univ, Coll Chem & Chem Engn, Nanning 530004, Guangxi, Peoples R China.
C3 Guangxi University of Science & Technology; Guangxi University
RP Li, LJ (corresponding author), Guangxi Univ Technol, Dept Biol & Chem Engn, Liuzhou 545006, Guangxi, Peoples R China.
EM lilijun0562@sina.com
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NR 12
TC 3
Z9 3
U1 0
U2 11
PU ASIAN JOURNAL OF CHEMISTRY
PI SAHIBABAD
PA 11/100 RAJENDRA NAGAR, SECTOR 3,, SAHIBABAD 201 005, GHAZIABAD, INDIA
SN 0970-7077
J9 ASIAN J CHEM
JI Asian J. Chem.
PD MAY
PY 2012
VL 24
IS 5
BP 2155
EP 2158
PG 4
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 955PQ
UT WOS:000305033800063
DA 2026-05-27
ER

PT J
AU Hsiao, YW
   Tsai, YN
   Huang, YT
   Liu, SH
   Lin, YJ
   Lo, LW
   Hu, YF
   Chung, FP
   Lin, SF
   Chang, SL
   Higa, S
   Chen, SA
AF Hsiao, Ya-Wen
   Tsai, Yung-Nan
   Huang, Yu-Ting
   Liu, Shuen-Hsin
   Lin, Yenn-Jiang
   Lo, Li-Wei
   Hu, Yu-Feng
   Chung, Fa-Po
   Lin, Shien-Fong
   Chang, Shih-Lin
   Higa, Satoshi
   Chen, Shih-Ann
TI Rhodiola crenulata reduces ventricular arrhythmia through mitigating the
   activation of IL-17 and inhibiting the MAPK signaling pathway
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Ventricular arrhythmias; Rhodiola crenulata; Inflammation; IL-17; MAPK
ID MYOCARDIAL-INFARCTION; ISCHEMIA-REPERFUSION; SALIDROSIDE; INJURY; HEART;
   ROOT
AB Purpose Ventricular arrhythmia (VA) is related to inflammatory activity. Rhodiola crenulate (RC) and its main active component, salidroside, have been reported as anti-inflammatory agents. The aim of this study was to demonstrate the effect of RC and salidroside in preventing VA via the inhibition of IL-17 in an ischemic heart failure (HF) model. Methods Rabbit HF models were established by coronary artery ligation for 4 weeks. These rabbits were treated with RC (125, 250, 500 mg/kg) and salidroside (9.5 mg/kg) once every 2 days for 4 weeks. WBC, serum biochemistry, ECG, and the expression of CD4(+)T cells were measured every 2 weeks. The mRNA and protein expressions of IL-17 were measured by real time-PCR, ELISA, and Western blotting after RC and salidroside treatment for 4 weeks. Open-chest epicardial catheter stimulation was performed for VA provocation. Results After RC and salidroside treatment in HF left ventricle, (1) the levels of WBC and CD4(+)T cells decreased, (2) the expression of IL-17 and its downstream target genes, IL-6, TNF-alpha, IL-1 beta, IL-8, and CCL20, reduced, (3) the level of NLRP3 inflammasome was decreased, (4) fibrosis and collagen production were significantly downregulated, (5) p38 MAPK and ERK1/2 phosphorylation were attenuated, (6) the inducibility of VA was decreased, and (7) the levels of Kir2.1, Nav1.5, NCX, PLB, SERCA2a and RyR were up-regulated. Conclusions RC inhibited the expression of IL-17 and its downstream target genes that were mediated by activation of several MAPKs, which decreased the levels of fibrosis and apoptosis and suppressed VA.
C1 [Hsiao, Ya-Wen; Huang, Yu-Ting; Lin, Yenn-Jiang; Lo, Li-Wei; Hu, Yu-Feng; Chung, Fa-Po; Chang, Shih-Lin; Chen, Shih-Ann] Taipei Vet Gen Hosp, Dept Med, Heart Rhythm Ctr, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan.
   [Hsiao, Ya-Wen; Huang, Yu-Ting; Lin, Yenn-Jiang; Lo, Li-Wei; Hu, Yu-Feng; Chung, Fa-Po; Chang, Shih-Lin; Chen, Shih-Ann] Taipei Vet Gen Hosp, Dept Med, Div Cardiol, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan.
   [Tsai, Yung-Nan] Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan.
   [Liu, Shuen-Hsin] Taipei Med Univ, Shuang Ho Hosp, Taipei, Taiwan.
   [Lin, Yenn-Jiang; Lo, Li-Wei; Hu, Yu-Feng; Chung, Fa-Po; Chang, Shih-Lin; Chen, Shih-Ann] Natl Yang Ming Univ, Dept Med, Sch Med, Taipei, Taiwan.
   [Lin, Shien-Fong] Natl Chiao Tung Univ, Inst Biomed Engn, Hsinchu, Taiwan.
   [Higa, Satoshi] Makiminato Cent Hosp, Div Cardiovasc Med, Cardiac Electrophysiol & Pacing Lab, Okinawa, Japan.
C3 Taipei Veterans General Hospital; Taipei Veterans General Hospital;
   National Yang Ming Chiao Tung University; Taipei Medical University;
   Shuang Ho Hospital; National Yang Ming Chiao Tung University; National
   Yang Ming Chiao Tung University
RP Chang, SL (corresponding author), Taipei Vet Gen Hosp, Dept Med, Heart Rhythm Ctr, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan.; Chang, SL (corresponding author), Taipei Vet Gen Hosp, Dept Med, Div Cardiol, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan.; Chang, SL (corresponding author), Natl Yang Ming Univ, Dept Med, Sch Med, Taipei, Taiwan.
EM ep.slchang@msa.hinet.net
RI ; Lin, Shien-fong/AAQ-1608-2020; Hsiao, Ya-Wen/MVY-7168-2025; Lo,
   LiWei/KRQ-6616-2024; Hu, Yu-Feng/V-1401-2019; Chang,
   Shih-Lin/AGT-1191-2022
OI HIGA, SATOSHI/0000-0002-5735-6249; Liu, Shuen-Hsin/0000-0003-3912-154X;
   Hu, Yu-Feng/0000-0001-5715-2070; 
FU Taipei Veterans General Hospital grant [V108C-055, V107C-041, V106C-056,
   VGHUST107-G1-7-1, MOST 106-2314-B-010-035-MY3, MOST 1052314-B-075-036,
   MOST104-2314-B-075-0, MOST104-2314-B-075024-MY3]; SZU-YUAN Research
   Foundation of Internal Medicine
FX This work was supported by Taipei Veterans General Hospital grant
   [V108C-055, V107C-041, V106C-056, VGHUST107-G1-7-1, MOST
   106-2314-B-010-035-MY3, MOST 1052314-B-075-036, MOST104-2314-B-075-0,
   MOST104-2314-B-075024-MY3] and SZU-YUAN Research Foundation of Internal
   Medicine.
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NR 36
TC 27
Z9 33
U1 5
U2 22
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD OCT
PY 2021
VL 35
IS 5
BP 889
EP 900
DI 10.1007/s10557-020-07072-z
EA SEP 2020
PG 12
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA UT8SR
UT WOS:000570823300002
PM 32946036
DA 2026-05-27
ER

PT J
AU Yao, Y
   Chen, FF
   Wu, CY
   Chang, XS
   Cheng, WJ
   Wang, QX
   Deng, ZX
   Liu, TG
   Lu, L
AF Yao, Yan
   Chen, Fangfang
   Wu, Chaoyan
   Chang, Xiaosa
   Cheng, Weijia
   Wang, Qiuxia
   Deng, Zixin
   Liu, Tiangang
   Lu, Li
TI Structure-based virtual screening aids the identification of
   glycosyltransferases in the biosynthesis of salidroside
SO PLANT BIOTECHNOLOGY JOURNAL
LA English
DT Article
DE plant biosynthetic enzyme; glycosyltransferases; salidroside; protein
   structure prediction; molecular docking; interdomain linker
ID CRYSTAL-STRUCTURES; GLUCOSYLTRANSFERASE; PREDICTION
AB Glycosylation plays an important role in the structural diversification of plant natural products. The identification of efficient glycosyltransferases is also a crucial step for the biosynthesis of valuable glycoside products. However, functional characterization of glycosyltransferases (GTs) from an extensive plant gene list is labour-intensive and challenging. Salidroside is a bioactive component derived from plants, widely utilized in the fields of food and medicine. Here, through transcriptome analysis and structure-based virtual screening, we identified two GTs that participated in the biosynthesis of salidroside from a rarely studied herbaceous plant, Astilbe chinensis. Ach15909 was found to possess high catalytic activity as evidenced by the determination of its catalytic parameters. The key residues that determine its catalytic activity were further determined. Additionally, Ach15909 shows a preference for substrates with a volume of <150 & Aring;(3), and replacing the interdomain linker region located between the N- and C-terminal domains of Ach15909 allows it to accept substrates that were previously not catalyzable. Overall, the structure-based virtual screening approach showed high efficiency and cost-effectiveness; the successful identification of GTs in salidroside glycosylation sheds light on uncovering additional plant biosynthesis enzymes in the forthcoming research.
C1 [Yao, Yan; Chen, Fangfang; Wu, Chaoyan; Chang, Xiaosa; Cheng, Weijia; Wang, Qiuxia; Deng, Zixin; Liu, Tiangang; Lu, Li] Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Integrated Tradit Chinese Med & Western Med, Wuhan, Peoples R China.
   [Yao, Yan; Chen, Fangfang; Chang, Xiaosa; Cheng, Weijia; Wang, Qiuxia; Deng, Zixin; Liu, Tiangang; Lu, Li] Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan, Peoples R China.
   [Yao, Yan; Chen, Fangfang; Lu, Li] Hubei Hongshan Lab, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University; Hubei Hongshan Laboratory
RP Lu, L (corresponding author), Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Integrated Tradit Chinese Med & Western Med, Wuhan, Peoples R China.; Lu, L (corresponding author), Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan, Peoples R China.; Lu, L (corresponding author), Hubei Hongshan Lab, Wuhan, Peoples R China.
EM luliwhu@whu.edu.cn
RI Lu, Li/LRU-5517-2024; Chen, Fangfang/P-2381-2016
OI Lu, Li/0000-0003-0490-7163; 
FU National Key Research and Development Program of China; Natural Science
   Foundation of China [32100413]; Wuhan University;  [2022YFA0912100]
FX This work is supported by National Key Research and Development Program
   of China grant 2022YFA0912100, Natural Science Foundation of China grant
   32100413, and a startup fund from Wuhan University.
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NR 51
TC 11
Z9 11
U1 32
U2 76
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7644
EI 1467-7652
J9 PLANT BIOTECHNOL J
JI Plant Biotechnol. J.
PD MAY
PY 2025
VL 23
IS 5
BP 1725
EP 1735
DI 10.1111/pbi.70002
EA FEB 2025
PG 11
WC Biotechnology & Applied Microbiology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Plant Sciences
GA 1UO0E
UT WOS:001420768400001
PM 39932927
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Peng, HL
   Li, WJ
   Ning, FJ
   Yao, LH
   Luo, M
   Zhu, XM
   Zhao, Q
   Xiong, H
AF Peng, Hailong
   Li, Wenjian
   Ning, Fangjian
   Yao, Lihua
   Luo, Mei
   Zhu, Xuemei
   Zhao, Qiang
   Xiong, Hua
TI Amphiphilic Chitosan Derivatives-Based Liposomes: Synthesis,
   Development, and Properties as a Carrier for Sustained Release of
   Salidroside
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE amphiphilic chitosan; liposomes; salidroside; sustained release; release
   mechanism
ID O-CARBOXYMETHYL CHITOSAN; IN-VITRO DIGESTION; POLYMERIC LIPOSOMES;
   DRUG-RELEASE; NANOPARTICLES; STABILITY; APOPTOSIS; BEHAVIOR
AB A novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesized. The structure of DCMCs was confirmed via FT-IR and H-1 NMR, and the critical micelle concentration (CMC) was investigated by fluorescence spectroscopy. The results indicated that DCMCs has hydrophilic carboxyl and hydrophobic methylene groups and the CMC value was 23.00 mg.L-1. The polymeric liposomes (DCMCs/cholesterol liposomes, DC-Ls) were developed, and its properties were evaluated. The DC-Ls exhibited multilamellar spheres with positive charge (+73.30 mV), narrow size distribution (PDI = 0.277), and good crystal properties. Salidroside was first to encapsulate into DC-Ls. Compared with,traditional liposomes (phosphatidylcholine/cholesterol liposome, PC-Ls), DC-Ls showed higher encapsulation efficiency (82.46%) and slower sustained release rate. The in vitro salidroside release from DC-Ls was governed by two distinct stages (i.e., burst release and sustained release) and was dependent on the pH of the release medium. The case II transport and case I Fichian diffusion were the main release mechanisms for the entire release procedure. These results indicated that DC-Ls may be a potential carrier system for the production of functional foods that contain salidroside or other bioactive food ingredients.
C1 [Peng, Hailong; Li, Wenjian; Ning, Fangjian; Luo, Mei; Zhu, Xuemei; Zhao, Qiang; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
   [Peng, Hailong; Luo, Mei] Nanchang Univ, Dept Chem Engn, Nanchang 330031, Jiangxi, Peoples R China.
   [Yao, Lihua] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang 330031, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Jiangxi Science & Technology
   Normal University
RP Xiong, H (corresponding author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
EM huaxiong100@126.com
RI ; Ning, Fangjian/AHA-4287-2022
OI Zhao, Qiang/0000-0002-9601-0304; Ning, Fangjian/0000-0001-6193-1704
FU Planning Subject of "the Twelfth Five-Year-Plan" National Science and
   Technology for the Rural development of China [2013AA102203-05];
   National Natural Science Foundation of China [31160317, 21201098,
   2126602, 81360205]
FX This work was supported by the Planning Subject of "the Twelfth
   Five-Year-Plan" National Science and Technology for the Rural
   development of China (2013AA102203-05), and the National Natural Science
   Foundation of China (31160317, 21201098, 2126602, and 81360205)
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NR 34
TC 31
Z9 42
U1 0
U2 166
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JAN 22
PY 2014
VL 62
IS 3
BP 626
EP 633
DI 10.1021/jf4039925
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Agriculture; Chemistry; Food Science & Technology
GA 296RI
UT WOS:000330202700012
PM 24372377
DA 2026-05-27
ER

PT J
AU Bi, YH
   Zhu, C
   Wang, ZY
   Jia, JB
AF Bi, Yanhong
   Zhu, Chun
   Wang, Zhaoyu
   Jia, Jianbo
TI Influence of the Ionic Liquid Cosolvent on Glucosylation Reactions
   Catalyzed by β-Glycosidase for Production of Salidroside
SO ASIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Ionic liquids; Salidroside; Glucosylation; Malus pumila seed meal
ID GREEN; BIOCATALYSIS
AB The enzymatic synthesis of salidroside catalyzed by beta-glycosidase from Malus pumila seed meal has been successfully carried out in ionic liquids-containing systems for the first time. The optimum conditions were screened out and the best yield of 24.9 % was received in the C(4)MIm center dot PF6-containing cosolvent system. Moreover, the influence of ionic liquids on the performance of the enzyme has been discussed, using both hydrophobic and hydrophilic ionic liquids possessing various anions and different alkyl chain lengths (C2-C10) in imidazolium cations.
C1 [Bi, Yanhong; Zhu, Chun; Wang, Zhaoyu; Jia, Jianbo] Huaiyin Inst Technol, Sch Life Sci & Chem Engn, Huaian 223003, Peoples R China.
C3 Huaian University
RP Wang, ZY (corresponding author), Huaiyin Inst Technol, Sch Life Sci & Chem Engn, Huaian 223003, Peoples R China.
EM biowzy@126.com
RI wang, zhaoyu/IQT-3451-2023
FU Qing Lan Project of Jiangsu Province; Natural Science Foundation of
   Jiangsu Province [BK2012243]; Natural Science Research Project of Higher
   Education of Jiangsu Province [10KJB530001]
FX This research was sponsored by Qing Lan Project of Jiangsu Province,
   Natural Science Foundation of Jiangsu Province (No. BK2012243) and
   Natural Science Research Project of Higher Education of Jiangsu Province
   (No. 10KJB530001).
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NR 16
TC 3
Z9 3
U1 1
U2 19
PU ASIAN JOURNAL OF CHEMISTRY
PI SAHIBABAD
PA 11/100 RAJENDRA NAGAR, SECTOR 3,, SAHIBABAD 201 005, GHAZIABAD, INDIA
SN 0970-7077
EI 0975-427X
J9 ASIAN J CHEM
JI Asian J. Chem.
PD AUG
PY 2013
VL 25
IS 9
BP 5095
EP 5098
DI 10.14233/ajchem.2013.14721
PN A
PG 4
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 227DC
UT WOS:000325087800092
OA gold
DA 2026-05-27
ER

PT J
AU Wu, R
   Wang, HM
   Cao, J
   Chen, LY
   Su, EZ
AF Wu Rong
   Wang Huimin
   Cao Jun
   Chen Luyao
   Su Erzheng
TI Simultaneous Extraction of Salidroside and Tyrosol from
   Rhodiolarosea L. Using Tailor-made Deep Eutectic Solvents
SO CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
LA Chinese
DT Article
DE Salidroside; Tyrosol; Deep eutectic solvent; Green solvent; Simultaneous
   extraction
ID SEPARATION; MEDIA
AB A method for simultaneously extracting the salidroside and tyrosol from Rhodiolarosea L. using deep eutectic solvents (DESs) as the extraction solvents was developed in this work. Firstly, the hydrogen bond donor (HBD), hydrogen bond acceptor (HBA), molar ratio of HBA to HBD, and water content were optimized. The optimal DES for the simultaneous extraction was obtained as ethylene glycol-levulinic acid at the molar ratio of 1 : 1 and water content of mass fraction of 40%, which was recorded as LAEG-40. Then, taking the LAEG-40 as the extraction solvent, the extraction conditions such as extraction method , solid to solvent ratio, extraction temperature and extraction time were further optimized. The optimal conditions were obtained as follows stirring extraction at the solid to solvent ratio of 1 : 12. 5(g/mL) and 60 degrees C for 65 min. Under these conditions, the extraction yields of salidroside and tyrosol reached (18. 1268 +/- 0. 1667) and (1. 5608 +/- 0. 0240) mg/g, respectively. However, under the same conditions, taking water or ethanol as the extraction solvents, the extraction yields of salidroside and tyrosol were (15. 1221 +/- 0. 1342) and (1. 1120 +/- 0. 0389) mg/g, or (16. 3425 +/- 0. 0897) and (1. 1923 +/- 0. 0423) mg/g, respectively. It could be seen that the extraction efficiency of LAEG-40 was obviously higher than those of traditional solvents. The results showed that LAEG-40 was a green and efficient solvent for simultaneous extraction of salidroside and tyrosol, which could be used as a substitute for traditional solvents.
C1 [Wu Rong; Wang Huimin; Cao Jun; Chen Luyao; Su Erzheng] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Coll Light Ind & Food Engn, Dept Food Sci & Technol,Coinnovat Ctr Efficient P, Nanjing 210037, Jiangsu, Peoples R China.
   [Su Erzheng] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
C3 Nanjing Forestry University; China Pharmaceutical University
RP Su, EZ (corresponding author), Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Coll Light Ind & Food Engn, Dept Food Sci & Technol,Coinnovat Ctr Efficient P, Nanjing 210037, Jiangsu, Peoples R China.; Su, EZ (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
EM ezhsu@njfu.edu.cn
RI Su, Erzheng/Q-3946-2019; luyao, chen/NXC-0013-2025
OI Su, Erzheng/0000-0002-3868-567X; 
FU "Six Talent Peaks" Project in Jiangsu Province, China [2015-JY-016];
   China Postdoctoral Science Foundation [2016M600417, 2017T100373]; Fifth
   Phase "333 Project" of Jiangsu Province, China [BRA2017458]; Open
   Project of State Key Laboratory of Natural Medicines, China
   Pharmaceutical University [201802]; Innovation and Entrepreneurship
   Training Program for College Students in Jiangsu Province, China
   [201810298139H, 201810298141H]
FX Supported by the "Six Talent Peaks" Project in Jiangsu Province,
   China(No. 2015-JY-016), the China Postdoctoral Science Foundation
   (Nos.2016M600417, 2017T100373), the Fifth Phase "333 Project" of Jiangsu
   Province, China(No. BRA2017458), the Open Project of State Key
   Laboratory of Natural Medicines, China Pharmaceutical
   University(No.201802) and the Innovation and Entrepreneurship Training
   Program for College Students in Jiangsu Province,
   China(Nos.201810298139H, 201810298141H).
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NR 27
TC 4
Z9 6
U1 1
U2 25
PU HIGHER EDUCATION PRESS
PI BEIJING
PA CHAOYANG DIST, 4, HUIXINDONGJIE, FUSHENG BLDG, BEIJING 100029, PEOPLES R
   CHINA
SN 0251-0790
J9 CHEM J CHINESE U
JI Chem. J. Chin. Univ.-Chin.
PD MAY 10
PY 2019
VL 40
IS 5
BP 918
EP 926
DI 10.7503/cjcu20180669
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA JC9XU
UT WOS:000489630700009
DA 2026-05-27
ER

PT J
AU Cui, JL
   Wang, YN
   Jiao, J
   Gong, Y
   Wang, JH
   Wang, ML
AF Cui, Jin-Long
   Wang, Ya-Nan
   Jiao, Jin
   Gong, Yi
   Wang, Jun-Hong
   Wang, Meng-Liang
TI Fungal endophyte-induced salidroside and tyrosol biosynthesis combined
   with signal cross-talk and the mechanism of enzyme gene expression in
   Rhodiola crenulata
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NITRIC-OXIDE; HYDROGEN-PEROXIDE; ERGOT ALKALOIDS; ACCUMULATION; ROSEA;
   IDENTIFICATION; METABOLITES; VALIDATION; SYMBIOSIS; CULTURES
AB Endophyte is a factor that affects the physiology and metabolism of plant. However, limited information is available on the mechanism of interaction between endophyte and plant. To investigate the effects of endophytic fungus ZPRs-R11, that is, Trimmatostroma sp., on salidroside and tyrosol accumulations in Rhodiola crenulata, signal transduction, enzyme gene expression, and metabolic pathway were investigated. Results showed that hydrogen peroxide (H2O2), nitric oxide (NO), and salicylic acid (SA) involved in fungus-induced salidroside and tyrosol accumulations. NO acted as an upstream signal of H2O2 and SA. No up- or down-stream relationship was observed, but mutual coordination existed between H2O2 and SA. Rate-limiting enzyme genes with the maximum expression activities were UDP-glucosyltransferase, tyrosine decarboxylase (TYDC), monoamine oxidase, phenylalanine ammonialyase (PAL), and cinnamic-4-hydroxylase sequentially. Nevertheless, the genes of tyrosine transaminase and pyruvate decarboxylase only indicated slightly higher activities than those in control. Thus, TYDC and PAL branches were the preferential pathways in ZPRs-R11-induced salidroside and tyrosol accumulation. Trimmatostroma sp. was a potential fungus for promoting salidroside and tyrosol accumulations. The present data also provided scientific basis for understanding complex interaction between endophytic fungus and R. crenulata.
C1 [Cui, Jin-Long; Wang, Ya-Nan; Jiao, Jin; Gong, Yi; Wang, Jun-Hong; Wang, Meng-Liang] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China.
   [Wang, Ya-Nan; Gong, Yi] Shanxi Univ, Inst Biotechnol, Taiyuan 030006, Shanxi, Peoples R China.
C3 Shanxi University; Shanxi University
RP Cui, JL (corresponding author), Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China.
EM cjl717@sxu.edu.cn; mlwang@sxu.edu.cn
FU National Natural Science Foundation of China [31270383, 31670328];
   Forestry Public Welfare Industry Research Special-Study on the
   integrated technology of vegetation restoration in the severe saline
   alkali soil in the north of Shanxi Province [201304326]
FX This research work was financially supported by the National Natural
   Science Foundation of China (No. 31270383, 31670328), and Forestry
   Public Welfare Industry Research Special-Study on the integrated
   technology of vegetation restoration in the severe saline alkali soil in
   the north of Shanxi Province (201304326). We also express our great
   thanks to Dr. Jason Slot (Department of Plant Pathologh, Ohio State
   University) for the language polishing.
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NR 44
TC 39
Z9 42
U1 3
U2 70
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 2
PY 2017
VL 7
AR 12540
DI 10.1038/s41598-017-12895-2
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FI5UG
UT WOS:000412050100061
PM 28970519
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, XJ
   Yang, J
   Luo, S
   Zhang, HC
   Liu, B
   Pan, ZQ
AF Wang, Xiaojie
   Yang, Jun
   Luo, Shuai
   Zhang, Hucheng
   Liu, Bo
   Pan, Zhiquan
TI Study of Salidroside and Its Inflammation Targeting Emulsion Gel for
   Wound Repair
SO MOLECULES
LA English
DT Article
DE salidroside; inflammation targeting; emulsion; gel; wound repair
ID NEGATIVELY CHARGED LIPOSOMES; IN-VITRO; CARRIER; CANCER; BFGF; RAT; EGF
AB Salidroside has been widely used in anti-tumor, cardiovascular, and cerebrovascular protection. However, there are few reports of its use for wound repair. Herein, salidroside inflammation-targeted emulsion gel and non-targeted emulsion gel were developed for wound repair. The inflammation-targeted emulsion gels showed an overall trend of better transdermal penetration and lower potential than non-targeted emulsion gels (-58.7 mV and -1.6 mV, respectively). The apparent improvement of the trauma surface was significant in each administration group. There was a significant difference in the rate of wound healing of the rats between each administration group and the model group at days 7 and 14. Pathological tissue sections showed that inflammatory cells in the epidermis, dermis, and basal layer were significantly reduced, and the granulation tissue was proliferated in the inflammation-targeted emulsion gel group and the non-targeted emulsion gel group. Regarding the expressions of EGF and bFGF, the expressions of bFGF and EGF in the tissues of the inflammation-targeted group at days 7, 14, or 21 were significantly higher than that of the non-targeted emulsion gel group and the model group, both of which were statistically significant compared with the model group (p < 0.05). These results demonstrated that salidroside has the potential as an alternative drug for wound repair.
C1 [Wang, Xiaojie; Pan, Zhiquan] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China.
   [Wang, Xiaojie; Yang, Jun; Luo, Shuai; Zhang, Hucheng] Beijing Polytech, Sch Biol Engn, Beijing 100176, Peoples R China.
   [Liu, Bo] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Britton Chance Ctr Biomed Photon,Wuhan Natl Lab Op, Dept Biomed Engn,Hubei Bioinformat & Mol Imaging K, Wuhan 430074, Peoples R China.
C3 Wuhan Institute of Technology; Beijing Polytechnic University; Huazhong
   University of Science & Technology
RP Pan, ZQ (corresponding author), Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China.; Liu, B (corresponding author), Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Britton Chance Ctr Biomed Photon,Wuhan Natl Lab Op, Dept Biomed Engn,Hubei Bioinformat & Mol Imaging K, Wuhan 430074, Peoples R China.
EM 100169@bpi.edu.cn; rainman@sina.com; luoshuai1985@sina.com;
   zhanghchbj@163.com; lbyang@mail.hust.edu.cn; zhiqpan@163.com
RI Zhang, Hucheng/GVS-0967-2022
FU Study on Dracorhodin Perchlorate Targeting Nano Preparation and Its
   Mechanism of Sciatica [2022X011-KXZ]
FX Study on Dracorhodin Perchlorate Targeting Nano Preparation and Its
   Mechanism of Sciatica (No. 2022X011-KXZ).
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NR 38
TC 4
Z9 5
U1 1
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2023
VL 28
IS 13
AR 5151
DI 10.3390/molecules28135151
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA M6AO3
UT WOS:001031025600001
PM 37446812
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Korbozova, NK
   Kudrina, NO
   Zhukova, NA
   Grazhdannikov, AE
   Blavachinskaya, I
   Seitimova, GA
   Kulmanov, TE
   Tolstikova, TG
   Terletskaya, N
AF Korbozova, Nazym K.
   Kudrina, Nataliya O.
   Zhukova, Nataliya A.
   Grazhdannikov, Alexander E.
   Blavachinskaya, Irina, V
   Seitimova, Gulnaz A.
   Kulmanov, Timur E.
   Tolstikova, Tatyana G.
   Terletskaya, Nina, V
TI Antihypothyroid Effect of Salidroside
SO MOLECULES
LA English
DT Article
DE Rhodiola semenovii Boriss; salidroside; thyroid; antihypothyroid effect
ID OXIDATIVE STRESS; QUANTITATIVE-DETERMINATION; THYROID-DYSFUNCTION;
   RHODIOLA-ROSEA; EXPRESSION; SEMENOVII; RATS
AB In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of Rhodiola spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from R. semenovii roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (p <= 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of R. semenovii extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.
C1 [Korbozova, Nazym K.; Kudrina, Nataliya O.; Blavachinskaya, Irina, V; Seitimova, Gulnaz A.; Terletskaya, Nina, V] Al Farabi Kazakh Natl Univ, Fac Biol & Biotechnol, Al Farabi Av 71, Alma Ata 050040, Kazakhstan.
   [Korbozova, Nazym K.; Kudrina, Nataliya O.; Blavachinskaya, Irina, V; Seitimova, Gulnaz A.; Terletskaya, Nina, V] Al Farabi Kazakh Natl Univ, Fac Chem & Chem Technol, Al Farabi Av 71, Alma Ata 050040, Kazakhstan.
   [Korbozova, Nazym K.; Kudrina, Nataliya O.; Seitimova, Gulnaz A.; Kulmanov, Timur E.; Terletskaya, Nina, V] Inst Genet & Physiol, Al Farabi Av 93, Alma Ata 050040, Kazakhstan.
   [Zhukova, Nataliya A.; Grazhdannikov, Alexander E.; Tolstikova, Tatyana G.] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia.
C3 Farabi University; Farabi University; Russian Academy of Sciences;
   Siberian Branch of the Russian Academy of Sciences; Vorozhtsov
   Novosibirsk Institute of Organic Chemistry
RP Terletskaya, N (corresponding author), Al Farabi Kazakh Natl Univ, Fac Biol & Biotechnol, Al Farabi Av 71, Alma Ata 050040, Kazakhstan.; Terletskaya, N (corresponding author), Al Farabi Kazakh Natl Univ, Fac Chem & Chem Technol, Al Farabi Av 71, Alma Ata 050040, Kazakhstan.; Terletskaya, N (corresponding author), Inst Genet & Physiol, Al Farabi Av 93, Alma Ata 050040, Kazakhstan.; Tolstikova, TG (corresponding author), Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia.
EM tg_tolstikova@mail.ru
RI ; Terletskaya, Nina/T-4097-2018; Kulmanov, Timur/JDW-1590-2023;
   Seitimova, Gulnaz/B-1744-2015; Kudrina, Nataliya/JDV-8793-2023
OI Блавачинская, Ирина/0009-0002-3371-0546; Terletskaya,
   Nina/0000-0003-3176-820X; Kulmanov, Timur/0000-0002-0865-3781;
   Seitimova, Gulnaz/0000-0002-5157-1255; Kuina,
   Natalya/0000-0002-0882-0447; 
FU Ministry of Education and Science of the Republic of Kazakhstan
   [AP08855699]
FX This research was carried out in the framework of the project AP08855699
   "The impact of abiotic stresses on the morphophysiological and
   phytochemical aspects of adaptation and biological activity of
   Kazakhstan plant Rhodiola semenovii Boriss." (2020-2022). This grant is
   funded by the Ministry of Education and Science of the Republic of
   Kazakhstan.
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NR 46
TC 4
Z9 4
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2022
VL 27
IS 21
AR 7487
DI 10.3390/molecules27217487
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6E8LX
UT WOS:000883626500001
PM 36364314
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, HX
   Li, XF
   Xin, X
   Yuan, K
   Wu, H
   Zhao, GL
AF Xu, Haixia
   Li, Xiaofeng
   Xin, Xuan
   Yuan, Kun
   Wu, Hui
   Zhao, Guanglei
TI Whole-Cell-Catalyzed Synthesis of Phenolic Glycoside Esters, and Their
   Antioxidant and Antimelanogenic Properties
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID TYROSINASE INHIBITORS; ENZYMATIC-SYNTHESIS; LIPASE; PHLORHIZIN;
   ESTERIFICATION; SALIDROSIDE; DERIVATIVES; FLAVONOIDS; CHEMISTRY;
   MECHANISM
AB Phenolic glycosides are the major secondary metabolites of plants, which exhibit multiple attractive biological and pharmacological activities. In this study, we developed a new and efficient method for acyl modification of phenolic glycosides by using whole-cell biocatalysts, aiming to improve their liposolubility and bioactivities. Using resveratrol, salidroside, piceid, and phlorizin as substrates, the substrate recognition characteristics of Candida parapsilosis were studied and salidroside showed the highest conversion (99.5%) but lower regioselectivity than others. Subsequently, the mechanism underlying the influences of the reaction time and organic solvents on the conversion and monoester ratio was revealed. A higher conversion of piceid was obtained in a green solvent (gamma-valerolactone) than that in THF (95.8 vs 94.6%). Compared to their parent compounds, all monoester products exhibit higher liposolubility and antioxidant activity. In addition, the monoesters of salidroside and phlorizin showed significantly higher tyrosinase-inhibiting and depigmentation activities than their parents.
C1 [Xu, Haixia; Li, Xiaofeng; Xin, Xuan; Yuan, Kun; Wu, Hui] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China.
   [Zhao, Guanglei] South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510641, Peoples R China.
C3 South China University of Technology; South China University of
   Technology
RP Li, XF (corresponding author), South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China.; Zhao, GL (corresponding author), South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510641, Peoples R China.
EM xflibio@scut.edu.cn; glzhao@scut.edu.cn
RI ; Xin, Xuan/AAC-7034-2019
OI Li, Xiao-feng/0000-0002-0144-6296; 
FU National key R&D Program of China [2018YFC1602200, 2018YFD0400805];
   National Natural Science Foundation of China [21676105, 21878107];
   Science and Technology Program of Guangzhou, China [201803020031]
FX This work is financially supported by National key R&D Program of China
   (2018YFC1602200, 2018YFD0400805), the National Natural Science
   Foundation of China (21676105, 21878107), and the Science and Technology
   Program of Guangzhou, China (201803020031).
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NR 44
TC 9
Z9 10
U1 4
U2 54
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
EI 1520-5045
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD SEP 23
PY 2020
VL 59
IS 38
BP 16591
EP 16602
DI 10.1021/acs.iecr.0c02940
PG 12
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA NX4LB
UT WOS:000575683100009
DA 2026-05-27
ER

PT J
AU Oh, JH
   Karadeniz, F
   Lee, JI
   Seo, Y
   Kong, CS
AF Oh, Jung Hwan
   Karadeniz, Fatih
   Lee, Jung Im
   Seo, Youngwan
   Kong, Chang-Suk
TI Ligustrum japonicum Thunb. Fruits Exert Antiosteoporotic
   Properties in Bone Marrow-Derived Mesenchymal Stromal Cells via
   Regulation of Adipocyte and Osteoblast Differentiation
SO STEM CELLS INTERNATIONAL
LA English
DT Article
AB Ligustrum japonicum fruits have been used as a part of traditional medicinal practices and supplements in Korea and Japan. It has been reported to possess various bioactivities, but its antiosteoporotic potential and active substances have not been reported yet. The present study followed an ALP activity and lipid accumulation-guided screening of L. japonicum fruits for antiosteoporotic compounds and isolated salidroside as an active compound. Antiosteoporotic effects of L. japonicum fruits and salidroside were examined in mesenchymal stromal cells by their ability to enhance osteoblast formation by increased ALP activity and osteogenic marker gene expression while suppressing adipogenesis by inhibition of lipid accumulation and adipocyte marker gene expressions. Results showed that salidroside was able to enhance osteoblast differentiation via Wnt/BMP signaling pathway overactivation and suppress the PPAR gamma-mediated adipocyte differentiation, both through the MAPK pathway. In conclusion, L. japonicum fruits were suggested to possess antiosteoporotic activities and to be a source of antiosteoporotic substances such as salidroside.
C1 [Oh, Jung Hwan; Karadeniz, Fatih; Lee, Jung Im; Kong, Chang-Suk] Silla Univ, Coll Med & Life Sci, Marine Biotechnol Ctr Pharmaceut & Foods, Busan 46958, South Korea.
   [Seo, Youngwan] Korea Maritime & Ocean Univ, Div Marine Biosci, Coll Ocean Sci & Technol, Busan 49112, South Korea.
   [Kong, Chang-Suk] Silla Univ, Dept Food & Nutr, Coll Med & Life Sci, Busan 46958, South Korea.
C3 Silla University; Korea Maritime & Ocean University; Silla University
RP Kong, CS (corresponding author), Silla Univ, Coll Med & Life Sci, Marine Biotechnol Ctr Pharmaceut & Foods, Busan 46958, South Korea.; Kong, CS (corresponding author), Silla Univ, Dept Food & Nutr, Coll Med & Life Sci, Busan 46958, South Korea.
EM wjdghks0171@naver.com; karadenizf@outlook.com; think3433@daum.net;
   ywseo@kmou.ac.kr; cskong@silla.ac.kr
RI Karadeniz, Fatih/JBJ-0348-2023
OI Karadeniz, Fatih/0000-0002-2484-0982
FU National Research Foundation of Korea (NRF) - Korea government (MSIP)
   [NRF-2017R1A2B4009588]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP) (No.
   NRF-2017R1A2B4009588).
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NR 38
TC 6
Z9 9
U1 1
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PD FEB 15
PY 2021
VL 2021
AR 8851884
DI 10.1155/2021/8851884
PG 17
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA QR5RD
UT WOS:000625273200002
PM 33628272
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, HY
   Tian, YJ
   Zhou, Y
   Kan, YY
   Wu, TT
   Xiao, WH
   Luo, YZ
AF Liu, Huayi
   Tian, Yujuan
   Zhou, Yi
   Kan, Yeyi
   Wu, Tingting
   Xiao, Wenhai
   Luo, Yunzi
TI Multi-modular engineering ofSaccharomyces cerevisiaefor
   high-titre production of tyrosol and salidroside
SO MICROBIAL BIOTECHNOLOGY
LA English
DT Article
ID AMINO-ACID BIOSYNTHESIS; SACCHAROMYCES-CEREVISIAE; AROMATIC-COMPOUNDS;
   ETHANOL-PRODUCTION; MEDICINAL-PLANTS; YEAST; PATHWAY; INHIBITION;
   STRESSES; SYSTEM
AB Tyrosol and its glycosylated product salidroside are important ingredients in pharmaceuticals, nutraceuticals and cosmetics. Despite the ability ofSaccharomyces cerevisiaeto naturally synthesize tyrosol, high yield fromde novosynthesis remains a challenge. Here, we used metabolic engineering strategies to constructS. cerevisiaestrains for high-level production of tyrosol and salidroside from glucose. First, tyrosol production was unlocked from feedback inhibition. Then, transketolase and ribose-5-phosphate ketol-isomerase were overexpressed to balance the supply of precursors. Next, chorismate synthase and chorismate mutase were overexpressed to maximize the aromatic amino acid flux towards tyrosol synthesis. Finally, the competing pathway was knocked out to further direct the carbon flux into tyrosol synthesis. Through a combination of these interventions, tyrosol titres reached 702.30 +/- 0.41 mg l(-1)in shake flasks, which were approximately 26-fold greater than that of the WT strain.RrU8GT33fromRhodiola roseawas also applied to cells and maximized salidroside production from tyrosol inS. cerevisiae. Salidroside titres of 1575.45 +/- 19.35 mg l(-1)were accomplished in shake flasks. Furthermore, titres of 9.90 +/- 0.06 g l(-1)of tyrosol and 26.55 +/- 0.43 g l(-1)of salidroside were achieved in 5 l bioreactors, both are the highest titres reported to date. The synergistic engineering strategies presented in this study could be further applied to increase the production of high value-added aromatic compounds derived from the aromatic amino acid biosynthesis pathway inS. cerevisiae.
C1 [Liu, Huayi; Tian, Yujuan; Zhou, Yi; Kan, Yeyi; Wu, Tingting; Luo, Yunzi] Sichuan Univ, West China Hosp, Dept Gastroenterol, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.
   [Xiao, Wenhai; Luo, Yunzi] Tianjin Univ, Frontier Sci Ctr Synthet Biol, Minist Educ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin,Sc, Tianjin 300072, Peoples R China.
   [Xiao, Wenhai; Luo, Yunzi] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin,Sc, Tianjin 300072, Peoples R China.
C3 Sichuan University; Nankai University; Tianjin University; Collaborative
   Innovation Center of Chemical Science & Engineering Tianjin; Nankai
   University; Tianjin University; Collaborative Innovation Center of
   Chemical Science & Engineering Tianjin
RP Luo, YZ (corresponding author), Sichuan Univ, West China Hosp, Dept Gastroenterol, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.; Luo, YZ (corresponding author), Tianjin Univ, Frontier Sci Ctr Synthet Biol, Minist Educ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin,Sc, Tianjin 300072, Peoples R China.; Luo, YZ (corresponding author), Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin,Sc, Tianjin 300072, Peoples R China.
EM yunzi.luo@tju.edu.cn
RI Luo, Yunzi/L-1290-2018; Liu, Huayi/KCK-1825-2024
OI Luo, Yunzi/0000-0002-5860-6350; Liu, Huayi/0000-0001-5179-1912
FU National Key R&D Program of China [2018YFA0903300]; Natural Science
   Foundation of Tianjin City [19JCYBJC24200]
FX We gratefully acknowledge the financial supports from the National Key
   R&D Program of China (Grant No. 2018YFA0903300), and the Natural Science
   Foundation of Tianjin City (Grant No. 19JCYBJC24200).
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NR 59
TC 95
Z9 115
U1 16
U2 238
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7915
J9 MICROB BIOTECHNOL
JI Microb. Biotechnol.
PD NOV
PY 2021
VL 14
IS 6
BP 2605
EP 2616
DI 10.1111/1751-7915.13667
EA SEP 2020
PG 12
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA WZ5HC
UT WOS:000574038200001
PM 32990403
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guo, W
   Huang, QL
   Feng, YH
   Tan, TC
   Niu, SH
   Hou, SL
   Chen, ZG
   Du, ZQ
   Shen, Y
   Fang, X
AF Guo, Wei
   Huang, Qiulan
   Feng, Yuhui
   Tan, Taicong
   Niu, Suhao
   Hou, Shaoli
   Chen, Zhigang
   Du, Zhi-Qiang
   Shen, Yu
   Fang, Xu
TI Rewiring central carbon metabolism for tyrosol and salidroside
   production in Saccharomyces cerevisiae
SO BIOTECHNOLOGY AND BIOENGINEERING
LA English
DT Article
DE d-erythrose 4-phosphate; phosphoketolase; Saccharomyces cerevisiae;
   salidroside; tyrosol
ID AROMATIC-COMPOUNDS; PATHWAY; YEAST; IDENTIFICATION; CASSETTES
AB Metabolic engineering of Saccharomyces cerevisiae for high-level production of aromatic chemicals has received increasing attention in recent years. Tyrosol production from glucose by S. cerevisiae is considered an environmentally sustainable and safe approach. However, the production of tyrosol and salidroside by engineered S. cerevisiae has been reported to be lower than 2 g/L to date. In this study, S. cerevisiae was engineered with a push-pull-restrain strategy to efficiently produce tyrosol and salidroside from glucose. The biosynthetic pathways of ethanol, phenylalanine, and tryptophan were restrained by disrupting PDC1, PHA2, and TRP3. Subsequently, tyrosol biosynthesis was enhanced with a metabolic pull strategy of introducing PcAAS and EcTyrA(M53I/A354V). Moreover, a metabolic push strategy was implemented with the heterologous expression of phosphoketolase (Xfpk), and then erythrose 4-phosphate was synthesized simultaneously by two pathways, the Xfpk-based pathway and the pentose phosphate pathway, in S. cerevisiae. Furthermore, the heterologous expression of Xfpk alone in S. cerevisiae efficiently improved tyrosol production compared with the coexpression of Xfpk and phosphotransacetylase. Finally, the tyrosol yield increased by approximately 135-folds, compared with that of parent strain. The total amount of tyrosol and salidroside with glucose fed-batch fermentation was over 10 g/L and reached levels suitable for large-scale production.
C1 [Guo, Wei; Huang, Qiulan; Feng, Yuhui; Tan, Taicong; Niu, Suhao; Chen, Zhigang; Du, Zhi-Qiang; Shen, Yu; Fang, Xu] Shandong Univ, State Key Lab Microbial Technol, Qingdao, Peoples R China.
   [Hou, Shaoli] Yantai Huakangrongzan Biotechnol Co Ltd, Yantai, Peoples R China.
   [Fang, Xu] Shandong Univ, Natl Glycoengn Res Ctr, Qingdao, Peoples R China.
C3 Shandong University; Shandong University
RP Fang, X (corresponding author), Shandong Univ, Natl Glycoengn Res Ctr, Qingdao, Peoples R China.; Du, ZQ; Shen, Y; Fang, X (corresponding author), 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China.
EM zhiqiangdu@sdu.edu.cn; shenyu@sdu.edu.cn; fangxu@sdu.edu.cn
RI Fang, Xu/B-8313-2015; Tan, Taicong/MSZ-3028-2025; Du,
   Zhiqiang/PHP-1744-2026
OI Fang, Xu/0000-0002-9196-5697; 
FU National Key R&D Program of China [2018YFA090010]; Major Program of
   Shandong Province Natural Science Foundation [ZR2018ZB0209]; Key
   Technologies R&D Program of Shandong Province [2018GSF121021]; 111
   Project [B16030]; State Key Laboratory of Microbial Technology Open
   Projects Fund [31870785, 31570040]; National Natural Science Foundation
   of China [31870785, 31570040]
FX National Key R&D Program of China, Grant/Award Number: 2018YFA090010;
   Major Program of Shandong Province Natural Science Foundation,
   Grant/Award Number: ZR2018ZB0209; Key Technologies R&D Program of
   Shandong Province, Grant/Award Number: 2018GSF121021; 111 Project,
   Grant/Award Number: B16030; State Key Laboratory of Microbial Technology
   Open Projects Fund and National Natural Science Foundation of China,
   Grant/Award Numbers: 31870785, 31570040
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NR 41
TC 57
Z9 73
U1 6
U2 206
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0006-3592
EI 1097-0290
J9 BIOTECHNOL BIOENG
JI Biotechnol. Bioeng.
PD AUG
PY 2020
VL 117
IS 8
BP 2410
EP 2419
DI 10.1002/bit.27370
EA MAY 2020
PG 10
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA MI1VA
UT WOS:000532689200001
PM 32369184
DA 2026-05-27
ER

PT J
AU Li, ZH
   Jia, B
   Guo, ZK
   Zhang, KQ
   Zhao, DF
   Li, ZH
   Fu, Q
AF Li, Zhenghao
   Jia, Bin
   Guo, Zhongkai
   Zhang, Keqin
   Zhao, Danfeng
   Li, Ziheng
   Fu, Qiang
TI Therapeutic potential of salidroside in type I diabetic erectile
   dysfunction: Attenuation of oxidative stress and apoptosis via the
   Nrf2/HO-1 pathway
SO PLOS ONE
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; RHODIOLA-ROSEA; SUPPLEMENTATION; MEDICINE; RATS
AB The primary objective of this work was to delve into the potential therapeutic advantages and dissect the molecular mechanisms of salidroside in enhancing erectile function in rats afflicted with diabetic microvascular erectile dysfunction (DMED), addressing both the whole-animal and cellular dimensions.We established a DMED model in Sprague-Dawley (SD) rats and conducted in vivo experiments. The DMED rats were administered varying doses of salidroside, the effects of which on DMED were compared. Erectile function was evaluated by applying electrical stimulation to the cavernous nerves and measuring intracavernous pressure in real time. The penile tissue underwent histological examination and Western blotting. Hydrogen peroxide (H2O2) was employed in the in vitro trial to induce an oxidative stress for the purpose of identifying alterations in cell viability. The CCK-8 assay was used to measure the viability of corpus cavernous smooth muscle cells (CCSMCs) treated with vs. without salidroside. Flow cytometry was utilized to detect alterations in intracellular reactive oxygen species (ROS). Apoptosis was assessed through Western blotting and TdT-mediated dUTP nick-end labelling (TUNEL). Animal and cellular experiments indicate that the Nrf2/HO-1 signalling pathway may be upregulated by salidroside, leading to the improvement of erectile function in diabetic male rats by alleviating oxidative stress and reducing apoptosis in corpus cavernosum tissue.
C1 [Li, Zhenghao; Guo, Zhongkai; Fu, Qiang] Shandong Univ, Shandong Prov Hosp, Dept Urol, Jinan, Shandong, Peoples R China.
   [Jia, Bin; Zhang, Keqin; Zhao, Danfeng; Fu, Qiang] Shandong First Med Univ, Shandong Prov Hosp, Dept Urol, Jinan, Shandong, Peoples R China.
   [Li, Ziheng] Shandong Rongjun Gen Hosp, Dept Surg 2, Jinan, Shandong, Peoples R China.
   [Fu, Qiang] Shandong First Med Univ, Key Lab Urinary Dis Univ Shandong, Jinan, Shandong, Peoples R China.
   [Fu, Qiang] Shandong First Med Univ, Shandong Prov Hosp, Engn Lab Urinary Organ & Funct Reconstruct Shandon, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong First Medical
   University & Shandong Academy of Medical Sciences
RP Fu, Q (corresponding author), Shandong Univ, Shandong Prov Hosp, Dept Urol, Jinan, Shandong, Peoples R China.; Fu, Q (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Urol, Jinan, Shandong, Peoples R China.; Fu, Q (corresponding author), Shandong First Med Univ, Key Lab Urinary Dis Univ Shandong, Jinan, Shandong, Peoples R China.; Fu, Q (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Engn Lab Urinary Organ & Funct Reconstruct Shandon, Jinan, Shandong, Peoples R China.
EM qiangfu68@163.com
RI FU, Qiang/JEF-7577-2023
OI Fu, Qiang/0000-0003-1916-1229
FX We thank the member of Engineering Laboratory of Urinary Organ and
   Functional Reconstruction of Shandong Province for their discussion and
   guidance on this study.
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NR 30
TC 10
Z9 12
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 11
PY 2024
VL 19
IS 7
AR e0306926
DI 10.1371/journal.pone.0306926
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YZ5H2
UT WOS:001272317500057
PM 38990890
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Alharbi, H
   Ahmad, M
   Tu, LY
   He, CX
AF Alharbi, Homood
   Ahmad, Mohammad
   Tu, Liya
   He, Chunxiao
TI Salidroside alleviates the progression of idiopathic pulmonary fibrosis
   by regulating ferroptosis
SO CYTOTECHNOLOGY
LA English
DT Article
DE Idiopathic pulmonary fibrosis; Ferroptosis; Salidroside
ID RHODIOLA-ROSEA L.; ACUTE LUNG INJURY; ACTIVATION
AB Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial pneumonia of unknown etiology, characterized by recurrent acute lung injury. This leads to worsening dyspnea and lung function decline. Patients with idiopathic pulmonary fibrosis (IPF) generally have a poor prognosis, often succumbing within 2-3 years of diagnosis, and the five-year survival rate is below 40%. Analysis of gene differences between raw and normal samples in the database, along with gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, suggests that ferroptosis may play a role in the development of pulmonary fibrosis. To test this hypothesis, transforming growth factor beta 1 (TGF-beta 1) was used to induce fibrosis in vitro, and levels of pulmonary fibrosis markers such as alpha-smooth muscle actin (alpha-SMA), fibronectin (FSN), and collagen (COL) were measured by enzyme-linked immunosorbent assay (ELISA). The results confirmed successful establishment of the pulmonary fibrosis model in vitro and indicated increased levels of ferroptosis markers, including glutathione (GSH) and iron accumulation. Salidroside, an extract from Rhodiola rosea, has been found to enhance glutathione levels in lung tissue, reduce oxidative stress, and decrease levels of alpha-SMA, FSN, COL, GSH, and iron in the model. These findings suggest that salidroside can mitigate pulmonary fibrosis by reversing ferroptosis. Additionally, we observed high expression of phospholipase A2 group IVA (PLA2G4A) in the fibrosis model, which was reduced by salidroside, indicating that salidroside may regulate ferroptosis via the PLA2G4A gene.
C1 [Alharbi, Homood; Ahmad, Mohammad] King Saud Univ, Coll Nursing, Dept Med Surg Nursing, Riyadh 11421, Saudi Arabia.
   [Tu, Liya; He, Chunxiao] Third Peoples Hosp Hangzhou, Dept Pharm, Hangzhou 310009, Zhejiang, Peoples R China.
   [He, Chunxiao] Shaoxing Peoples Hosp, Dept Pulm & Crit Care Med, 568 Zhongxing North Rd, Shaoxing 312000, Zhejiang, Peoples R China.
C3 King Saud University
RP He, CX (corresponding author), Third Peoples Hosp Hangzhou, Dept Pharm, Hangzhou 310009, Zhejiang, Peoples R China.; He, CX (corresponding author), Shaoxing Peoples Hosp, Dept Pulm & Crit Care Med, 568 Zhongxing North Rd, Shaoxing 312000, Zhejiang, Peoples R China.
EM sanford6735@yandex.com
FU Deanship of Scientific Research, College of Nursing, Research Centre at
   King Saud University
FX The authors are thankful to the Deanship of Scientific Research, College
   of Nursing, Research Centre at King Saud University, for supporting this
   research.
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NR 33
TC 0
Z9 0
U1 4
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-9069
EI 1573-0778
J9 CYTOTECHNOLOGY
JI Cytotechnology
PD AUG 14
PY 2025
VL 77
IS 5
AR 161
DI 10.1007/s10616-025-00831-6
PG 10
WC Biotechnology & Applied Microbiology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Cell Biology
GA 6CK9L
UT WOS:001550038300001
PM 40822624
OA Green Accepted
DA 2026-05-27
ER

PT J
AU Bai, XL
   Deng, XL
   Wu, GJ
   Li, WJ
   Jin, S
AF Bai, Xiang-Li
   Deng, Xiu-Ling
   Wu, Guang-Jie
   Li, Wen-Jing
   Jin, Si
TI Rhodiola and Salidroside in the Treatment of Metabolic Disorders
SO MINI-REVIEWS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE AMPK; autophagy; metabolic disorders; mitochondria; Rhodiola;
   Salidroside
ID C-REACTIVE PROTEIN; STANDARDIZED EXTRACT SHR-5; PEROXIDE-INDUCED INJURY;
   APOPTOTIC CELL-DEATH; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE; ROSEA EXTRACT; DOUBLE-BLIND; ENDOTHELIAL FUNCTION
AB Over the past three decades, the knowledge gained about the mechanisms that underpin the potential use of Rhodiola in stress- and ageing-associated disorders has increased, and provided a universal framework for studies that focused on the use of Rhodiola in preventing or curing metabolic diseases. Of particular interest is the emerging role of Rhodiola in the maintenance of energy homeostasis. Moreover, over the last two decades, great efforts have been undertaken to unravel the underlying mechanisms of action of Rhodiola in the treatment of metabolic disorders. Extracts of Rhodiola and salidroside, the most abundant active compound in Rhodiola, are suggested to provide a beneficial effect in mental, behavioral, and metabolic disorders. Both in vivo and ex vivo studies, Rhodiola extracts and salidroside ameliorate metabolic disorders when administered acutely or prior to experimental injury. The mechanism involved includes multi-target effects by modulating various synergistic pathways that control oxidative stress, inflammation, mitochondria, autophagy, and cell death, as well as AMPK signaling that is associated with possible beneficial effects on metabolic disorders. However, evidence-based data supporting the effectiveness of Rhodiola or salidroside in treating metabolic disorders is limited. Therefore, a comprehensive review of available trials showing putative treatment strategies of metabolic disorders that include both clinical effective perspectives and fundamental molecular mechanisms is warranted. This review highlights studies that focus on the potential role of Rhodiola extracts and salidroside in type 2 diabetes and atherosclerosis, the two most common metabolic diseases.
C1 [Wu, Guang-Jie; Li, Wen-Jing; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Geriatr Med, Dept Endocrinol,Liyuan Hosp, Wuhan 430077, Hubei, Peoples R China.
   [Bai, Xiang-Li] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Clin Lab,Inst Geriatr Med, Wuhan 430077, Hubei, Peoples R China.
   [Deng, Xiu-Ling] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430030, Hubei, Peoples R China.
   [Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharmacol, Wuhan 430030, Hubei, Peoples R China.
   [Jin, Si] Clin Res Ctr Diabet Foot & Wound Healing Hubei Pr, Wuhan 430077, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Geriatr Med, Dept Endocrinol,Liyuan Hosp, Wuhan 430077, Hubei, Peoples R China.
EM Jinsi@hust.edu.cn
RI jin, si/KGK-5977-2024
OI jin, si/0000-0003-0727-6715
FU National Natural Science Foundation of China [81373413, 81573432,
   81072634, 81503072]; Ministry of Education of China [NCET-0100409];
   Fundamental Research Funds for the Central Universities [2015ZHYX006,
   2016YXZD023, 0118550041]
FX The authors' work cited in this review was supported by grants from the
   National Natural Science Foundation of China (81373413, 81573432,
   81072634, and 81503072) and a grant from Ministry of Education of China
   (NCET-0100409). Grants from the Fundamental Research Funds for the
   Central Universities (2015ZHYX006, 2016YXZD023, and 0118550041).
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NR 171
TC 45
Z9 54
U1 0
U2 49
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-5575
EI 1875-5607
J9 MINI-REV MED CHEM
JI Mini-Rev. Med. Chem.
PY 2019
VL 19
IS 19
BP 1611
EP 1626
DI 10.2174/1389557519666190903115424
PG 16
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JU7IG
UT WOS:000501845500005
PM 31481002
DA 2026-05-27
ER

PT J
AU Wang, YR
   Xu, P
   Wang, Y
   Liu, HY
   Zhou, YW
   Cao, XB
AF Wang, Yunru
   Xu, Peng
   Wang, Yang
   Liu, Haiyan
   Zhou, Yuwen
   Cao, Xuebin
TI The Protection of Salidroside of the Heart against Acute Exhaustive
   Injury and Molecular Mechanism in Rat
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID REPERFUSION INJURY; OXIDATIVE STRESS; EXERCISE; APOPTOSIS; INHIBITION;
   SKELETAL
AB Objective. To investigate the protection of salidroside of the heart against acute exhaustive injury and its mechanism of antioxidative stress and MAPKs signal transduction. Method. Adult male SD rats were divided into four groups randomly. Cardiomyocytes ultrastructure was observed by optical microscopy and transmission electron microscopy. The contents of CK, CK-MB, LDH, MDA, and SOD were determined by ELISA method, and the phosphorylation degrees of ERK and p38 MAPK were assayed by Western blotting. Cardiac function of isolated rat heart ischemia/reperfusion was detected by Langendorff technique. Results. Salidroside reduced the myocardium ultrastructure injury caused by exhaustive swimming, decreased the contents of CK, CK-MB, and LDH, improved the LVDP,+/- LV dp/dt(max) under the basic condition, reduced the content of MDA and the phosphorylation degree of p38 MAPK, and increased the content of SOD and the phosphorylation degree of ERK in acute exhaustive rats. Conclusion. Salidroside has the protection of the heart against acute exhaustive injury. The cardioprotection is mainly mediated by antioxidative stress and MAPKs signal transduction through reducing the content of MDA, increasing the content of SOD, and increasing p-ERK and decreasing p-p38 protein expressions in rat myocardium, which might be the mechanisms of the cardioprotective effect of salidroside.
C1 [Wang, Yunru; Xu, Peng; Wang, Yang; Liu, Haiyan; Zhou, Yuwen; Cao, Xuebin] 252 Hosp PLA, Dept Cardiol, Geriatr Cardiovasc Dis Res & Treatment Ctr, Baoding 071000, Peoples R China.
RP Cao, XB (corresponding author), 252 Hosp PLA, Dept Cardiol, Geriatr Cardiovasc Dis Res & Treatment Ctr, Baoding 071000, Peoples R China.
EM caoxb252@163.com
RI WANG, YU RU/HOH-6896-2023; Xu, Peng/GXF-8681-2022
FU Medical Science Research Program of Chinese Army [CWS12J064]; Medical
   Technology Project of Chinese Army [BWS11J058]
FX This study was supported by Medical Science Research Program of Chinese
   Army (no. CWS12J064) and Medical Technology Project of Chinese Army (no.
   BWS11J058).
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NR 17
TC 15
Z9 20
U1 1
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 507832
DI 10.1155/2013/507832
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 279YB
UT WOS:000328994200001
PM 24454984
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Li, W
   Dou, DQ
   Koike, K
AF Li, Wei
   Dou, Deqiang
   Koike, Kazuo
TI Revised absolute stereochemistry of rhodiolosides A-D, rhodiolol A and
   sachalinol A from Rhodiola rosea
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Rhodiola rosea; Crassulaceae; monoterpene; glycoside; rhodioloside
ID MONOTERPENE GLYCOSIDES
AB The absolute stereochemistry of rhodiolosides A-D (1-4), four monoterpene glycosides from the roots of Rhodiola rosea, and their aglycones, rhodiolol A (5), (-)-rosiridol (6) and sachalinol A (7), were reinvestigated. It was found that the absolute configurations of C-4 in these compounds, previously assigned to be 4-R, should be revised to 4-S.
C1 [Li, Wei; Koike, Kazuo] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan.
   [Dou, Deqiang] Liaoning Univ Tradit Chinese Med, Coll Pharm, Shenyang 110032, Peoples R China.
C3 Toho University; Liaoning University of Traditional Chinese Medicine
RP Koike, K (corresponding author), Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Chiba 2748510, Japan.
EM koike@phar.toho-u.ac.jp
RI Li, Wei/Y-1312-2018; Dou, Deqiang/GLR-4592-2022
OI Li, Wei/0000-0003-4143-8597; 
CR Ma G, 2006, CHEM PHARM BULL, V54, P1229, DOI 10.1248/cpb.54.1229
   Yoshikawa M, 2008, CHEM PHARM BULL, V56, P695, DOI 10.1248/cpb.56.695
NR 2
TC 7
Z9 7
U1 0
U2 8
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD JUL
PY 2008
VL 56
IS 7
BP 1047
EP 1048
DI 10.1248/cpb.56.1047
PG 2
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 333VE
UT WOS:000258180000037
PM 18591831
OA Bronze
DA 2026-05-27
ER

PT J
AU Peng, HL
   Dong, RC
   Wang, SQ
   Zhang, Z
   Luo, M
   Bai, CQ
   Zhao, Q
   Li, JH
   Chen, LX
   Xiong, H
AF Peng, Hailong
   Dong, Ruichen
   Wang, Shenqi
   Zhang, Zhong
   Luo, Mei
   Bai, Chunqing
   Zhao, Qiang
   Li, Jinhua
   Chen, Lingxin
   Xiong, Hua
TI A pH-responsive nano-carrier with mesoporous silica nanoparticles cores
   and poly(acrylic acid) shell-layers: Fabrication, characterization and
   properties for controlled release of salidroside
SO INTERNATIONAL JOURNAL OF PHARMACEUTICS
LA English
DT Article
DE Mesoporous silica nanoparticles; Poly(acrylic acid); pH-responsive;
   Controlled release; Salidroside
ID SOLID-PHASE EXTRACTION; RHODIOLA-ROSEA; DRUG-DELIVERY; IN-VITRO; SYSTEM;
   APOPTOSIS
AB A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The vinyl double bonds modified MSNs were synthesized by using cetyltrimethylammonium bromide (CTAB) as templates, tetraethyl orthosilicate (TEOS) as silicon source, and 3-(trimethoxylsilyl) propyl methacrylate (MPS) as surface modification functionalities. The pH-responsive layers of PAA were grafted onto the vinyl double bonds of the MSNs via precipitation polymerization, producing the MSNs-PAA with a hollow cubic core and mesoporous shell with penetrating pore channels. The characteristic results also showed that PAA was successfully grafted onto the surface of the MSNs. The MSNs-PAA was investigated as carriers for loading and regulating the release of salidroside in different pH solutions for the first time. The results demonstrated that the PAA layers on the surface of MSNs-PAA exhibited opened and closed states at different pH values, and thus could regulate the uptake and release of salidroside. The application of such pH-responsive nano-carrier might offer a potential platform for controlled delivery and increasing the bioavailability of drugs. (C) 2013 Elsevier B. V. All rights reserved.
C1 [Peng, Hailong; Dong, Ruichen; Wang, Shenqi; Luo, Mei; Bai, Chunqing; Zhao, Qiang; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China.
   [Peng, Hailong; Luo, Mei] Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China.
   [Zhang, Zhong; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China.
C3 Nanchang University; Nanchang University; Chinese Academy of Sciences;
   Yantai Institute of Coastal Zone Research, CAS
RP Xiong, H (corresponding author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China.
EM huaxiong100@yahoo.com.cn
RI ; Chen （陈令新）, Lingxin/H-5761-2019; Li, Jinhua/J-6706-2014
OI Zhao, Qiang/0000-0002-9601-0304; Chen （陈令新）,
   Lingxin/0000-0002-3764-3515; 
FU National Natural Science Foundation of China [21201098, 31160317,
   21275158, 21105117]; Specialized Research Fund for the Doctoral Program
   of Higher Education [20113601110004]; 100 Talents Program of the Chinese
   Academy of Sciences
FX This work was supported by the National Natural Science Foundation of
   China (21201098, 31160317, 21275158, 21105117), the Specialized Research
   Fund for the Doctoral Program of Higher Education (20113601110004), and
   the 100 Talents Program of the Chinese Academy of Sciences.
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NR 41
TC 116
Z9 133
U1 3
U2 289
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5173
EI 1873-3476
J9 INT J PHARMACEUT
JI Int. J. Pharm.
PD MAR 25
PY 2013
VL 446
IS 1-2
BP 153
EP 159
DI 10.1016/j.ijpharm.2013.01.071
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 114JI
UT WOS:000316736500019
PM 23395877
DA 2026-05-27
ER

PT J
AU Zhang, W
   Peng, M
   Yang, Y
   Xiao, ZW
   Song, B
   Lin, ZF
AF Zhang, Wei
   Peng, Ming
   Yang, Yang
   Xiao, Zhangwu
   Song, Bin
   Lin, Zhaofen
TI Protective Effects of Salidroside on Mitochondrial Functions against
   Exertional Heat Stroke-Induced Organ Damage in the Rat
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; CARDIOMYOCYTES; DYSFUNCTION;
   APOPTOSIS; PLASMA; ROS
AB Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. The present study was designed to evaluate the protective effects of salidroside on EHS by improving mitochondrial functions in the rat model. Liver and heart mitochondria were observed by transmission electron microscopy and mitochondrial membrane potential (Delta Psi m) was detected by a fluorescent probe. Intramitochondrial free Ca2+ concentration, mitochondrial respiratory control ratio (RCR), reactive oxygen species (ROS) levels, superoxide dismutase (SOD), and malondialdehyde (MDA) activity were detected by the corresponding kits. RT-PCR was performed to estimate peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) and manganese form of SOD (MnSOD) mRNA expression. The results demonstrated that salidroside was able to relieve EHS damage by reducing the swelling of mitochondria, ROS levels, and MDA activity, as well as increasing Delta Psi m, RCR, free Ca2+ concentration, SOD, PGC-1 alpha, and MnSOD mRNA levels. In conclusion, salidroside has protective effects on mitochondrial functions against exertional heat stroke-induced organ damage in the rat.
C1 [Zhang, Wei] Second Mil Med Univ, Affiliated Fuzhou Gen Hosp, Dept Emergency, Fuzhou 350025, Fujian, Peoples R China.
   [Peng, Ming; Yang, Yang; Xiao, Zhangwu] Fuzhou Gen Hosp, Dept Emergency, Fuzhou 350025, Fujian, Peoples R China.
   [Song, Bin] Fuzhou Gen Hosp, Dept Med, Fuzhou 350025, Peoples R China.
   [Lin, Zhaofen] Shanghai Changzheng Hosp, Dept Emergency, Shanghai 200003, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Song, B (corresponding author), Fuzhou Gen Hosp, Dept Med, Fuzhou 350025, Peoples R China.
EM gjw1217@163.com
FU Nanjing Military Region Science Foundation [10z033]
FX This work was supported by the Nanjing Military Region Science
   Foundation-funded major project (no. 10z033).
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NR 24
TC 27
Z9 29
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2015
VL 2015
AR 504567
DI 10.1155/2015/504567
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CX2RG
UT WOS:000365543700001
PM 26664452
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Hu, FL
   Liao, XY
   Chen, ZL
AF Hu, Fangli
   Liao, Xiaoyan
   Chen, Zilin
TI Determination of three phenylethanoid glycosides in Osmanthus
   fragrans fruits by high-performance liquid chromatography with
   fluorescence detection
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE fluorescence detection; high-performance liquid chromatography;
   Osmanthus fragrans fruits; phenylethanoid glycosides
ID SECOIRIDOID GLUCOSIDES; RAT PLASMA; SALIDROSIDE; IDENTIFICATION;
   QUANTITATION; SEEDS
AB A simple and sensitive high-performance liquid chromatography with fluorescence detection method has been developed for the determination of active components in Osmanthus fragrans fruits. In this work, reversed-phase liquid chromatography with a C18 column and mobile phase of methanol/water were applied to effectively separate three phenylethanoid glycosides, including salidroside, neonuezhenide, and nuezhenide. The limits of detection of salidroside, neonuezhenide, and nuezhenide were 3.9, 25.4, and 24.2 ng/mL respectively. Then this method was applied to determine the contents in several batches of O. fragrans fruits extract, which were collected fromWuhan, Hefei, and Changsha. Meanwhile, the method was used for the detection of rat plasma administrated with O. fragrans fruits extract, which could be an alternative method applied to the field of pharmacokinetics study in future. The results implied that the developed method was economical, simple, convenient, and sensitive, which was appropriate for the determination of salidroside, neonuezhenide, and nuezhenide in O. fragrans fruits.
C1 Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan, Hubei, Peoples R China.
   [Chen, Zilin] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Chen, ZL (corresponding author), Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China.
EM chenzl@whu.edu.cn
FU National Natural Science Foundation of China [81872828, 81573384]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos: 81872828 and 81573384).
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NR 24
TC 7
Z9 9
U1 3
U2 50
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD NOV
PY 2018
VL 41
IS 21
BP 3995
EP 4000
DI 10.1002/jssc.201800610
PG 6
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA GZ6IC
UT WOS:000449537800005
PM 30182503
DA 2026-05-27
ER

PT J
AU Zhang, YT
   Zhang, K
   Wu, ZH
   Guo, T
   Ye, BN
   Lu, MY
   Zhao, JH
   Zhu, CY
   Feng, NP
AF Zhang, Yongtai
   Zhang, Kai
   Wu, Zhonghua
   Guo, Teng
   Ye, Beini
   Lu, Mingyun
   Zhao, Jihui
   Zhu, Chunyun
   Feng, Nianping
TI Evaluation of transdermal salidroside delivery using niosomes via in
   vitro cellular uptake
SO INTERNATIONAL JOURNAL OF PHARMACEUTICS
LA English
DT Article
DE Nanocarrier; Topical administration; Cellular uptake; Endocytosis;
   Biocompatibility
ID NONIONIC SURFACTANT VESICLES; DRUG-DELIVERY; FORMULATION; SYSTEMS;
   MELANOGENESIS; CHOLESTEROL; EXTRACT; CARRIER; CELLS
AB Span 40-based niosomes were employed as nanocarriers to improve cutaneous absorption of salidroside. The niosomal formulation with a molar proportion of Span 40 to cholesterol of 4:3 showed the highest transdermal flux and skin deposition of salidroside. The transdermal flux of the 4:3 niosomal formulation was significantly greater than that of the aqueous solution. Salidroside-loaded niosomes showed good biocompatibility with skin tissue, human epidermal immortal keratinocytes (HaCaT), and human embryonic skin fibroblasts (CCC-ESF). The fluorescence intensity of HaCaT cells after uptake of coumarin 6-labeled niosomes was similar to that observed after uptake of the aqueous suspension. The fluorescence intensity of CCC-ESF cells was greater than that of the aqueous suspension after incubation for 10 min, but was not significantly different after 60 min. Further investigation revealed that internalization of niosomes by HaCaT cells may be achieved through pinocytotic vesicles and macropinocytosis, which consumes energy, rather than via lysosomes. In CCC-ESF cells, pinocytotic vesicles and lysosomes were both important mediators of endocytosis. The niosome formulations reported here could improve the dermal and transdermal salidroside delivery, and the in vitro cell uptake evaluation results serve as a basis for further research into the mechanisms through which niosomes enhance drug permeability. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Zhang, Yongtai; Zhang, Kai; Wu, Zhonghua; Guo, Teng; Ye, Beini; Lu, Mingyun; Zhao, Jihui; Zhu, Chunyun; Feng, Nianping] Shanghai Univ Tradit Chinese Med, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Feng, NP (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China.
EM npfeng@hotmail.com
RI Wu, Zhonghua/V-8258-2019; Zhang, Yongtai/AEH-9113-2022; Feng,
   Nianping/ABG-5415-2021
OI Wu, Zhonghua/0000-0002-8036-022X; Zhang, Yongtai/0000-0002-1427-4868;
   Feng, Nianping/0000-0002-5303-2941
FU State Education Ministry of China [NCET08-0898]; National Natural
   Science Foundation of China [81303234]; Youth Scientific Research
   Foundation from Shanghai Municipal Health Bureau [20134Y098]; Shanghai
   Municipal Education Commission [2013JW12]
FX This work was financially supported by a project (NCET08-0898) from the
   State Education Ministry of China, National Natural Science Foundation
   of China (81303234), Youth Scientific Research Foundation (20134Y098)
   from Shanghai Municipal Health Bureau, and a grant (2013JW12) from
   Shanghai Municipal Education Commission.
CR Abdelkader H., 2014, J PHARM INVEST
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NR 32
TC 59
Z9 66
U1 1
U2 65
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5173
EI 1873-3476
J9 INT J PHARMACEUT
JI Int. J. Pharm.
PD JAN 15
PY 2015
VL 478
IS 1
BP 138
EP 146
DI 10.1016/j.ijpharm.2014.11.018
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CA0QF
UT WOS:000348621100017
PM 25448576
DA 2026-05-27
ER

PT J
AU Qu, ZQ
   Zhou, Y
   Zeng, YS
   Lin, YK
   Li, Y
   Zhong, ZQ
   Chan, WY
AF Qu, Ze-qiang
   Zhou, Yan
   Zeng, Yuan-shan
   Lin, Yu-kun
   Li, Yan
   Zhong, Zhi-qiang
   Chan, Wood Yee
TI Protective Effects of a Rhodiola Crenulata Extract and
   Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced
   Neural Injury in the Rat
SO PLOS ONE
LA English
DT Article
ID PEROXIDE-INDUCED APOPTOSIS; OXIDATIVE STRESS; STEM-CELLS;
   INTRACEREBROVENTRICULAR STREPTOZOTOCIN; COGNITIVE IMPAIRMENT;
   ENERGY-METABOLISM; DENTATE GYRUS; ROSEA EXTRACT; OLIVE OIL; TYROSOL
AB Previously we have demonstrated that a Rhodiola crenulata extract (RCE), containing a potent antioxidant salidroside, promotes neurogenesis in the hippocampus of depressive rats. The current study was designed to further investigate the protective effect of the RCE on neurogenesis in a rat model of Alzheimer's disease (AD) induced by an intracerebroventricular injection of streptozotocin (STZ), and to determine whether this neuroprotective effect is induced by the antioxidative activity of salidroside. Our results showed that pretreatment with the RCE significantly improved the impaired neurogenesis and simultaneously reduced the oxidative stress in the hippocampus of AD rats. In vitro studies revealed that (1) exposure of neural stem cells (NSCs) from the hippocampus to STZ strikingly increased intracellular reactive oxygen species (ROS) levels, induced cell death and perturbed cell proliferation and differentiation, (2) hydrogen peroxide induced similar cellular activities as STZ, (3) pre-incubation of STZ-treated NSCs with catalase, an antioxidant, suppressed all these cellular activities induced by STZ, and (4) likewise, pre-incubation of STZ-treated NSCs with salidroside, also an antioxidant, suppressed all these activities as catalase: reduction of ROS levels and NSC death with simultaneous increases in proliferation and differentiation. Our findings indicated that the RCE improved the impaired hippocampal neurogenesis in the rat model of AD through protecting NSCs by its main ingredient salidroside which scavenged intracellular ROS.
C1 [Qu, Ze-qiang; Zhou, Yan; Zeng, Yuan-shan; Lin, Yu-kun; Li, Yan; Zhong, Zhi-qiang] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Histol & Embryol, Div Neurosci, Guangzhou 510275, Guangdong, Peoples R China.
   [Zeng, Yuan-shan] Sun Yat Sen Univ, Minist Educ, Key Lab Stem Cells & Tissue Engn, Guangzhou 510275, Guangdong, Peoples R China.
   [Chan, Wood Yee] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Chinese University of
   Hong Kong
RP Qu, ZQ (corresponding author), Sun Yat Sen Univ, Zhongshan Sch Med, Dept Histol & Embryol, Div Neurosci, Guangzhou 510275, Guangdong, Peoples R China.
EM zengysh@mail.sysu.edu.cn; wy-chan@cuhk.edu.hk
RI Chan, Wood Yee/R-6692-2018
OI Chan, Wood Yee/0000-0002-7114-1463
FU Administrative Bureau of Chinese Traditional Medicine of Guangdong
   Province [2007109]
FX This research was supported by a research grant of the Administrative
   Bureau of Chinese Traditional Medicine of Guangdong Province (No.
   2007109) to YSZ. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 3
PY 2012
VL 7
IS 1
AR e29641
DI 10.1371/journal.pone.0029641
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 903NK
UT WOS:000301123400080
PM 22235318
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Dou, XB
   Ding, QC
   Lai, SL
   Jiang, FS
   Song, Q
   Zhao, XD
   Fu, A
   Moustaid-Moussad, N
   Su, DJ
   Li, ST
AF Dou, Xiaobing
   Ding, Qinchao
   Lai, Shanglei
   Jiang, Fusheng
   Song, Qing
   Zhao, Xindi
   Fu, Ai
   Moustaid-Moussad, Naima
   Su, Dongju
   Li, Songtao
TI Salidroside alleviates lipotoxicity-induced cell death through
   inhibition of TLR4/MAPKs pathway, and independently of AMPK and
   autophagy in AML-12 mouse hepatocytes
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Salidroside; Lipotoxicity; TLR4; MAPK; Hepatocytes
ID ENDOTHELIAL PROGENITOR CELLS; FATTY LIVER-DISEASE; OXIDATIVE STRESS;
   PALMITIC ACID; PROTECTS HEPATOCYTES; INSULIN-RESISTANCE; SIRTUIN 3;
   APOPTOSIS; ACTIVATION; DYSFUNCTION
AB Lipotoxicity plays a detrimental role in the pathogenesis of non-alcoholic fatty liver diseases (NAFLD). Salidroside (Sal), a phenylpropanoid glycoside extracted from Rhodiola rosea L, conferred resistance to high-fat diet-induced liver injury. However, the underlying mechanisms are still unclear. This study aimed at investigating Sal-inhibited lipotoxicity and clarify its potential mechanisms. Our study indicated that Sal significantly reversed palmitic acids-induced injury in dose-dependent manner in AML-12 mouse hepatocytes, accompanied with improvement of oxidative stress and mitochondrial damage. Mechanistic analysis revealed that Sal protected hepatic lipotoxicity via reversing TLR4/MAPKs (including JNK, p38, and ERk1/2) and p53 activation, independent from autophagy, AMPK, and Akt pathways. Moreover, TLR4 inhibition also contributed to salidroside-reduced lipids deposition. In sum, this research clearly demonstrated the protective effects of Sal against lipotoxicity-induced hepatic cell death, which was mediated by downregulation of TLR4/MAPKs pathways in hepatocytes. We conclude that Sal is a potential candidate for the treatment of NAFLD.
C1 [Li, Songtao] Zhejiang Chinese Med Univ, Coll Basic Med & Publ Hlth, Hangzhou 310053, Peoples R China.
   [Dou, Xiaobing; Ding, Qinchao; Lai, Shanglei; Jiang, Fusheng; Song, Qing; Zhao, Xindi; Fu, Ai] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Peoples R China.
   [Su, Dongju] Harbin Med Univ, Affiliated Hosp 2, Harbin 150081, Peoples R China.
   [Moustaid-Moussad, Naima] Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.
   [Moustaid-Moussad, Naima] Texas Tech Univ, Obes Res Inst, Lubbock, TX 79409 USA.
   [Dou, Xiaobing; Ding, Qinchao; Lai, Shanglei; Jiang, Fusheng; Song, Qing; Zhao, Xindi; Fu, Ai; Li, Songtao] Zhejiang Chinese Med Univ, Mol Med Inst, Hangzhou 310053, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Harbin Medical University; Texas Tech University System;
   Texas Tech University; Texas Tech University System; Texas Tech
   University; Zhejiang Chinese Medical University
RP Li, ST (corresponding author), Zhejiang Chinese Med Univ, Coll Basic Med & Publ Hlth, Hangzhou 310053, Peoples R China.; Su, DJ (corresponding author), Harbin Med Univ, Affiliated Hosp 2, Harbin 150081, Peoples R China.
EM sudongju@hrbmu.edu.cn; lisongtao@zcmu.edu.cn
OI Ding, Qinchao/0000-0001-8664-5368
FU Natural Science Foundation of China [81773422, 81973041, 81773981];
   Zhejiang Natural Science Foundation for Distinguished Young Scholars
   [LR20H260001]; Zhejiang Medical and Health Science and Technology
   Project [2019310630]
FX This work was supported by grants from the Natural Science Foundation of
   China (81773422, 81973041 & 81773981), Zhejiang Natural Science
   Foundation for Distinguished Young Scholars (LR20H260001), and Zhejiang
   Medical and Health Science and Technology Project (2019310630).
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NR 56
TC 14
Z9 15
U1 1
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2020
VL 65
AR 103691
DI 10.1016/j.jff.2019.103691
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KI3HF
UT WOS:000511239100005
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Huang, LR
   Xu, JX
   Jia, K
   Wu, YL
   Yuan, W
   Liao, ZP
   Cheng, B
   Luo, Q
   Tian, GY
   Lu, HQ
AF Huang, Lirong
   Xu, Jiaxin
   Jia, Kun
   Wu, Yulin
   Yuan, Wei
   Liao, Zhipeng
   Cheng, Bo
   Luo, Qiang
   Tian, Guiyou
   Lu, Huiqiang
TI Butylparaben induced zebrafish ( Danio rerio ) kidney injury by
   down-regulating the PI3K-AKT pathway
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Butylparaben; Renal toxicity; Salidroside; HEK293T; Zebrafish
ID SALIDROSIDE; MECHANISMS; PARABENS; EXPOSURE; INFLAMMATION; BIOMARKERS;
   SYSTEM; BREAST; LIVER; MODEL
AB Butylparaben, a common endocrine disruptor in the environment, is known to be toxic to the reproductive system, heart, and intestines, but its nephrotoxicity has rarely been reported. In order to study the nephrotoxicity and mechanism of butylparaben, we examined the acute and chronic effects on human embryonic kidney cells (HEK293T) and zebrafish. Additionally, we assessed the potential remedial effects of salidroside against butylparaben-induced nephrotoxicity. Our in vitro findings demonstrated oxidative stress and cytotoxicity to HEK293T cells caused by butylparaben. In the zebrafish model, the concentration of butylparaben exposure ranged from 0.5 to 15 mu M. An assortment of experimental techniques was employed, including the assessment of kidney tissue morphology using Hematoxylin-Eosin staining, kidney function analysis via fluorescent dextran injection, and gene expression studies related to kidney injury, development, and function. Additionally, butylparaben caused lipid peroxidation in the kidney, thereby damaging glomeruli and renal tubules, which resulted from the downregulation of the PI3K-AKT signaling pathway. Furthermore, salidroside ameliorated butylparaben-induced nephrotoxicity through the PI3K-AKT signaling pathway. This study reveals the seldom reported kidney toxicity of butylparaben and the protective effect of salidroside against toxicological reactions related to nephrotoxicity. It offers valuable insights into the risks to kidney health posed by environmental toxins.
C1 [Huang, Lirong; Xu, Jiaxin; Jia, Kun; Wu, Yulin; Yuan, Wei; Liao, Zhipeng; Cheng, Bo; Luo, Qiang; Tian, Guiyou] Gannan Normal Univ, Sch Geog & Environm Engn, Ganzhou Key Lab Drug Screening & Discovery, Ganzhou 341000, Jiangxi, Peoples R China.
   [Lu, Huiqiang] Gannan Med Univ, Affiliated Hosp 1, Ctr Clin Med Res, Ganzhou 341000, Jiangxi, Peoples R China.
C3 Gannan Normal University; Gannan Medical University
RP Lu, HQ (corresponding author), Gannan Med Univ, Affiliated Hosp 1, Ctr Clin Med Res, Ganzhou 341000, Jiangxi, Peoples R China.
EM luhq2@126.com
RI Wu, Yulin/JAX-2276-2023
FU National Key R&D Program of China [2018YFA0801000]; National Natural
   Science Foundation of China [32170853]; Natural Science Foundation of
   Jiangxi Province [20212ACB205007]
FX This work was supported by the National Key R&D Program of China
   [2018YFA0801000]. National Natural Science Foundation of China
   [32170853], Natural Science Foundation of Jiangxi Province
   [20212ACB205007].
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NR 64
TC 14
Z9 15
U1 12
U2 83
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD MAY 15
PY 2024
VL 470
AR 134129
DI 10.1016/j.jhazmat.2024.134129
EA APR 2024
PG 13
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA QP2G0
UT WOS:001222002700001
PM 38565019
DA 2026-05-27
ER

PT J
AU Tasheva, K
   Dimitrova, M
   Lazarova, M
   Misheva, S
   Kosturkova, G
AF Tasheva, Krasimira
   Dimitrova, Margarita
   Lazarova, Mariya
   Misheva, Svetlana
   Kosturkova, Georgina
TI PRODUCTION OF THE PHENOLS SALIDROSIDE AND ROSAVINS IN RHODIOLA ROSEA
   REGENERANTS EX VITRO ADAPTED TO NATURAL CONDITIONS
SO COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
LA English
DT Article
DE ex vitro; HPLC; in vitro; medicinal plant; Rhodiola rosea
ID L.
AB Rhodiola rosea L. is a high-altitude medicinal plant with various health -beneficial effects, associated mainly with the phenolic substances salidroside and rosavins (rosavin, rosin and rosarin). The intensive collection of R. rosea rhizomes and roots to be used in folk medicine and pharmacy has led to a decrease of the species natural resources. New opportunities for species con-servation and accelerated synthesis of biologically active substances have been provided by various systems for in vitro and ex vitro cultivation. In this study, the salidroside and rosavins content was determined using HPLC analysis in in vitro cultures of R. rosea and further monitored in adapted regenerants grown ex vitro. The targeted secondary metabolites were not detected in the calli and in the roots of 1-month-old regenerants obtained on different nutrient media. The roots/rhizomes of adapted regenerants grown ex vitro in a greenhouse for 1 year and in the mountain for 1, 2 and 3 years produced increasing amounts of salidroside (from 0.4 to 1.2%) and rosavins (from 4.3 to 4.5%). The salidroside to rosavins ratio (1:3.75) in 3-year-old regenerants grown in the mountain was close to the pharmacopoeial standard ratio of 1:3. These results show that R. rosea plants, obtainted by in vitro micropropagation and grown ex vitro are promising for drug production.
C1 [Tasheva, Krasimira; Dimitrova, Margarita; Misheva, Svetlana; Kosturkova, Georgina] Bulgarian Acad Sci, Inst Plant Physiol & Genet, Dept Plant Ecophysiol, Akad G Bonchev St,Bl 25, Sofia 1113, Bulgaria.
   [Lazarova, Mariya] Bulgarian Acad Sci, Inst Neurobiol, Akad G Bonchev St,Bl 23, Sofia 1113, Bulgaria.
C3 Bulgarian Academy of Sciences; Bulgarian Academy of Sciences
RP Tasheva, K (corresponding author), Bulgarian Acad Sci, Inst Plant Physiol & Genet, Dept Plant Ecophysiol, Akad G Bonchev St,Bl 25, Sofia 1113, Bulgaria.
EM krasitasheva@abv.bg; mstoyadinova@abv.bg; s_landjeva@mail.bg;
   m.lazarova@gmail.com; georgina_kosturkova@abv.bg
RI Dimitrova, Margarita/AGX-9763-2022; Misheva, Svetlana/AAT-6697-2021
OI Misheva, Svetlana/0000-0002-1923-999X
CR Brown R.P., 2002, Herbalgram, V56, P40
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NR 15
TC 0
Z9 0
U1 1
U2 5
PU PUBL HOUSE BULGARIAN ACAD SCI
PI SOFIA
PA ACADEMICIAN G BONCEV ST, 1113 SOFIA, BULGARIA
SN 1310-1331
J9 CR ACAD BULG SCI
JI C. R. Acad. Bulg. Sci.
PY 2023
VL 76
IS 9
BP 1360
EP 1367
DI 10.7546/CRABS.2023.09.06
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Y9ZA3
UT WOS:001108757800008
OA gold
DA 2026-05-27
ER

PT J
AU Ding, Y
   Ju, ZC
   Ma, C
AF Ding, Yan
   Ju, Zhengcai
   Ma, Chao
TI A validated LC-MS/MS method for the determination of specnuezhenide and
   salidroside in rat plasma and its application to a pharmacokinetic study
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE bioavailability; pharmacokinetic; salidroside; specnuezhenide
AB The aim of this study was to establish and validate a rapid and sensitive LC-MS/MS method for the simultaneous determination of specnuezhenide and its bioactive metabolite salidroside in rat plasma. Protein precipitation was carried out and the analytes were separated on a Waters Acquity UPLC HSS T3 column (2.1 x 100 mm, 1.8 mu m). A mobile phase consisting of acetonitrile and 0.1% formic acid aqueous solution was used for elution under gradient conditions at a flow rate of 0.4 mL/min. Quantification was performed in the negative multiple reaction monitoring mode with precursor-to-product transitions at m/z 685.2 -> 453.1 for specnuezhenide, m/z 229.3 -> 119.0 for salidroside and 493.2 -> 147.1 for the internal standard. The method showed good linearity, accuracy, precision and stability in the range 0.5-500.0 ng/mL for specnuezhenide and salidroside. The values of the matrix effect were within the range of 100.02-111.87% for both analytes, while the mean extraction recovery was within the range 64.19-78.26%. The intra- and inter-day precisions (RSD) were <13.49% and the accuracy (RR) ranged from 93.59 to 102.24%. This study was successfully utilized for the pharmacokinetic study of specnuezhenide in rats after oral and intravenous administration. The oral bioavailability of specnuezhenide was 1.93%.
C1 [Ding, Yan] Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Ju, Zhengcai; Ma, Chao] Shanghai Univ Tradit Chinese Med, Inst Chinese Materia Med, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Ding, Y (corresponding author), Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
EM dingyan.369@163.com
RI Ma, Chao/ABC-9692-2020
OI Ma, Chao/0000-0003-2100-8776
FU Budget Project of Shanghai University of Traditional Chinese Medicine
   [18LK021, 2016YSN12]
FX The Budget Project of Shanghai University of Traditional Chinese
   Medicine, Grant/Award Number: 18LK021 and 2016YSN12
CR Cai Z., 1998, ACAD J SEC MIL MED U, V19, P76
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NR 17
TC 6
Z9 7
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD DEC
PY 2018
VL 32
IS 12
AR e4353
DI 10.1002/bmc.4353
PG 7
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA HD3KI
UT WOS:000452414600005
PM 30062793
DA 2026-05-27
ER

PT J
AU Li, T
   He, X
AF Li, Tao
   He, Xuan
TI Quantitative Analysis of Salidroside and p-Tyrosol in the
   Traditional Tibetan Medicine Rhodiola crenulata by Fourier
   Transform Near Infrared-Spectroscopy
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Fourier transform near-infrared spectroscopy; Rhodiola crenulata;
   salidroside; p-tyrosol; quantitative analysis; partial least square
ID REFLECTION SPECTROSCOPY; QUANTIFICATION ANALYSIS; CHROMATOGRAPHY;
   SPECTROMETRY; PERFORMANCE; VALIDATION; SPECTRA; PLANTS; PART; L.
AB A nondestructive, efficient, and.rapid method for quantitative analysis of two bioactive.,components (salidroside and p-tyrosol) in Rhodiola crenulata, a traditional Tibetan medicine, by Fourier transform near-infrared (FT-NIR) spectroscopy was developed. Near-infrared diffuse reflectance spectra in the range of 4000 to 10000 cm(-1) of 50 samples of Rhodiola crenulata with different sources were measured. To get a satisfying result, partial least squares regression (PLSR) was used to establish NIR models for salidroside and p-tyrosol content determination. Different preprocessing methods, including smoothing, taking a second derivative, standard normal variate (SNV) transformation, and multiplicative scatter correction (MSC), were investigated to improve the model accuracy of PLSR. The performance of the two final models (salidroside model and p-tyrosol model) was evaluated by factors such as the values of correlation coefficient (R-2), root mean square error of prediction (RMSEP), and root mean square error of calibration (RMSEC). The optimal results of the PLSR model of salidroside showed that R-2, RMSEP and RMSEC were 0.99572, 0.0294 and 0.0309, respectively. Meanwhile, in the optimization model of p-tyrosol, the R-2, RMSEP and RMSEC were 0.99714, 0.0154 and 0.0168, respectively. These results demonstrate that FT-NIR spectroscopy not only provides a precise, rapid method for quantitative analysis of major effective constituents in Rhodiola crenulata, but can also be applied to the quality control of Rhodiola crenulata.
C1 [Li, Tao; He, Xuan] Sichuan Univ, West China Sch Pharm, 17 Sect 3,Ren Min Nan Lu Rd, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University
RP Li, T (corresponding author), Sichuan Univ, West China Sch Pharm, 17 Sect 3,Ren Min Nan Lu Rd, Chengdu 610041, Sichuan, Peoples R China.
EM scdxlitao@scu.edu.cn
RI Li, Tao/HTQ-4759-2023; He, Xuan/NSU-4645-2025
FU Science and Technology Department of Sichuan Province Research Fund
   [2016JY0247]
FX This research was supported by the Science and Technology Department of
   Sichuan Province Research Fund (Grant No.: 2016JY0247). We are also
   grateful to Dr. Carden, kelly A. (The University of Iowa, America) for
   proofreading an early version of the manuscript.
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NR 30
TC 24
Z9 30
U1 4
U2 54
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD APR
PY 2016
VL 64
IS 4
BP 289
EP 296
DI 10.1248/cpb.c15-00558
PG 8
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry
GA DI1HD
UT WOS:000373246300001
PM 27039830
OA gold
DA 2026-05-27
ER

PT J
AU Rattan, S
   Warghat, AR
AF Rattan, Shiv
   Warghat, Ashish R.
TI Comparative analysis of salidroside and rosavin accumulation and
   expression analysis of biosynthetic genes in salicylic acid and methyl
   jasmonate elicited cell suspension culture of Rhodiola imbricata
   (Edgew.)
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Rhodiola imbricata; Elicitor; Cell culture; Salidroside; Total phenolic
   content; Gene expression
ID PATHWAY; GROWTH
AB Elicitation has been shown to be a very effective tool for improving bioactive molecule accumulation in various cell culture systems. The current study observed the effects of salicylic acid (SA) and methyl jasmonate (MeJA) on the increased accretion of salidroside and rosavin, as well as the transcriptional response of their biosynthetic genes in Rhodiola imbricata cell suspension culture. Suspension-cultured cells were treated with different con-centrations of elicitors (SA and MeJA; 25, 50, 75, and 100 mu M) on the 16th day of the incubation period and evaluated for growth biomass, metabolite content, and gene expression analysis after 24, 48, 72, and 96 h of elicitor treatment. The enhanced salidroside (7.71 mg/g DW) and rosavin (0.99 mg/g DW) contents were ach-ieved in 50 mu M SA elicitation. Similarly, MeJA elicitation improved salidroside (1.85 mg/g DW) and rosavin (0.67 mg/g DW) content in 100 mu M concentration. In 50 mu M SA and 100 mu M MeJA elicitation, total phenolics were significantly increased (16.11 mg/g DW; 7.69 mg/g DW). Total flavonoids were detected at their highest levels (9.78 mg/g DW; 6.69 mg/g DW) in 50 mu M SA and 100 mu M MeJA elicitation, respectively. Furthermore, after SA and MeJA treatment, transcript level gene expression revealed a higher expression pattern of aromatic-L-amino-acid decarboxylase (TDC) and Uridine 5 '-diphospho-glucuronosyltransferase (UGT 73 C) genes in salidroside biosynthesis. While in rosavin biosynthesis, SA and MeJA elicitation significantly increased the expression levels of cinnamyl alcohol dehydrogenase (CAD) and cinnamoyl-CoA reductase (CCR). Overall, the study suggests that elicitation of SA and MeJA improved specialized metabolite accumulation and expression of key pathway genes in R. imbricata suspension-cultured cells.
C1 [Rattan, Shiv; Warghat, Ashish R.] Inst Himalayan Bioresource Technol, Biotechnol Div, CSIR, Palampur 176061, Himachal Prades, India.
   [Rattan, Shiv; Warghat, Ashish R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR)
RP Warghat, AR (corresponding author), Inst Himalayan Bioresource Technol, Biotechnol Div, CSIR, Palampur 176061, Himachal Prades, India.
EM ashishwarghat@ihbt.res.in
RI Warghat, Ashish/AAS-6726-2020
FU Council of Scientific and Industrial Research (CSIR) , Government of
   India [MLP-0201]; National Medicinal Plants Board (NMPB) [GAP-0274]
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR) , Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection and utilization of
   Himalayan bioresources" (MLP-0201) and National Medicinal Plants Board
   (NMPB) , "Development of Probiotics for Plant Tissue Culture Boosting
   the performance of micro propagated plant materials by supplementing
   plant-associated useful endophytes" (GAP-0274) for providing financial
   support.
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NR 43
TC 7
Z9 7
U1 4
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD AUG
PY 2023
VL 198
AR 116667
DI 10.1016/j.indcrop.2023.116667
EA APR 2023
PG 10
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA F6ZV8
UT WOS:000983815900001
DA 2026-05-27
ER

PT J
AU Chen, J
   Cheng, QB
   Ma, QQ
   Wu, YQ
   Zhang, LW
AF Chen, Jue
   Cheng, Qibin
   Ma, Qianqian
   Wu, Yuqi
   Zhang, Liwei
TI Salidroside synthesis via glycosylation by β-D-glucosidase immobilized
   on chitosan microspheres in deep eutectic solvents
SO BIOCATALYSIS AND BIOTRANSFORMATION
LA English
DT Article
DE Deep eutectic solvents; salidroside; beta-D-glucosidase; biocatalysis
ID APPLE SEED MEAL; ENZYME; OLIGOSACCHARIDES; ALCOHOLS; CELLS
AB This study aimed to establish a novel method for catalysing salidroside synthesis by immobilized 18-D-glucosidase with deep eutectic solvents (DESs) as a new green non-aqueous medium. To this end, the catalytic properties of 18-D-glucosidase (i.e. activity, stability, and enzymatic properties) were analysed within sixteen different DESs systems. Although most DESs significantly improved enzyme stability, they also reduced enzymatic activity. This was verified at the molecular level by employing fluorescence spectroscopy to evaluate conformational changes in 18-D-glucosidase molecules. Subsequently, chitosan microspheres were used to immobilize 18-D-glucosidase; the structures of the microspheres and immobilized enzyme were observed by scanning electron microscopy (SEM). Through single factor experiments and application of a response surface design, the optimal conditions for production of salidroside by the reaction of tyrosol with immobilized 18-D-glucosidase were established. These conditions comprised 80 vol% ChCl/G (1:2), 50 degrees C reaction temperature, 5.8 pH, 100 h reaction time, 45 U/mL enzyme dosage, and a tyrosol/D-glucose molar ratio of 10. Under these conditions, the average conversion rate of the tyrosol substrate was 31.6%. Moreover, a salidroside crude product was obtained with a purity > 70% (g/g) and a substrate conversion rate of immobilized 18-D-glucosidase > 50% of its initial value after five repeated uses. Collectively, this study establishes a novel green reaction system for the efficient preparation of salidroside and other glycoside compounds, while also providing a theoretical foundation for the analysis of 18-D-glucosidase catalytic reactions in DESs systems.
C1 [Chen, Jue; Ma, Qianqian; Wu, Yuqi] Shanxi Univ Chinese Med, Coll Chinese Med & Food Engn, Taiyuan, Peoples R China.
   [Cheng, Qibin; Zhang, Liwei] Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan, Peoples R China.
C3 Shanxi University of Chinese Medicine; Shanxi University
RP Zhang, LW (corresponding author), Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan, Peoples R China.
EM lwzhang@sxu.edu.cn
FU Basic Research Program of Shanxi Province [202203021212348]; Shanxi
   University of Chinese Medicine [2020BK13]; construction of a Chinese
   medicine discipline at Shanxi University of Chinese Medicine [1008Z3]
FX This study was supported by the Basic Research Program of Shanxi
   Province [No. 202203021212348], the doctoral research initiation fund of
   Shanxi University of Chinese Medicine [No. 2020BK13], and the
   construction of a Chinese medicine discipline at Shanxi University of
   Chinese Medicine [No. 1008Z3].
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NR 45
TC 7
Z9 9
U1 4
U2 42
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1024-2422
EI 1029-2446
J9 BIOCATAL BIOTRANSFOR
JI Biocatal. Biotransform.
PD MAR 3
PY 2024
VL 42
IS 2
BP 227
EP 240
DI 10.1080/10242422.2023.2178308
EA FEB 2023
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA LQ1V8
UT WOS:000936841800001
DA 2026-05-27
ER

PT J
AU Zhu, LP
   Chen, T
   Chang, XY
   Zhou, R
   Luo, F
   Liu, JY
   Zhang, K
   Wang, Y
   Yang, Y
   Long, HY
   Liu, Y
   Yan, TH
   Ma, CH
AF Zhu, Lingpeng
   Chen, Tong
   Chang, Xiayun
   Zhou, Rui
   Luo, Fen
   Liu, Jingyan
   Zhang, Kai
   Wang, Yue
   Yang, Ying
   Long, Hongyan
   Liu, Yu
   Yan, Tianhua
   Ma, Chunhua
TI Salidroside ameliorates arthritis-induced brain cognition deficits by
   regulating Rho/ROCK/NF-κB pathway
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Salidroside; Arthritis; Brain cognition deficits; Inflammation;
   Rho/ROCK/NF-kappa B
ID ACUTE LUNG INJURY; RHEUMATOID-ARTHRITIS; SYNTHETIC SALIDROSIDE;
   CELL-ADHESION; RHO-GTPASES; D-GALACTOSE; IN-VITRO; MICE; RAT; FATIGUE
AB The prevalence of cognitive impairment in rheumatoid arthritis (RA) patients was increasingly serious nowadays. The purpose of the current study was to explore whether salidroside (Sal) could alleviate arthritis-induced cognition deficits and examine the relationship between the impairment and Rho/ROCK/NF-kappa B pathway. Collagen-induced arthritis (CIA) was established by the injection of chicken type II collagen (CII), complete Freund's adjuvant (CFA) and incomplete Freund's adjuvant (IFA). Arthritic lesions of CIA rats were assessed by arthritis index score, swelling of paws and histological analysis. Cognitive deficits symptoms of CIA rats were monitored through Morris water maze test. The contents of pro inflammatory cytokines tumor necrosis factor-alpha (TNE-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) in hippocampus and serum were significantly reduced with salidroside (20 mg/kg, 40 mg/kg) treatment compared with those in the CIA group. In parallel, we demonstrated that the expressions of RhoA, ROCK1, ROCK2, p-NF-kappa Bp65, p-I kappa B alpha, p-IKK alpha and p-IKK beta were enhanced accompanying the investigation arthritis-induced cognition deficits, which were remarkably down-regulated by salidroside and confirmed by the results obtained from western blot and immunohistochemistry. LC-MS/MS results ascertained that Sal could enter into the blood and brain tissues to exhibit the protective effect on arthritis-induced cognitive dysfunction. Therefore, it was assumed that Sal might be a potential therapeutic candidate to treat arthritis-induced brain cognition deficits through the regulation of Rho/ROCK/NF-kappa B signaling. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Zhu, Lingpeng; Liu, Yu; Yan, Tianhua] China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, Nanjing 210009, Peoples R China.
   [Zhu, Lingpeng; Chang, Xiayun; Zhou, Rui; Luo, Fen; Liu, Jingyan; Yan, Tianhua; Ma, Chunhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.
   [Chen, Tong] China Pharmaceut Univ, Dept Pharmacol, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
   [Zhang, Kai] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Peoples R China.
   [Wang, Yue; Yang, Ying] China Pharmaceut Univ, Sch Engn, Nanjing 210009, Peoples R China.
   [Long, Hongyan] Nanjing Univ TCM, Affiliated Hosp 3, Nanjing Municipal Hosp TCM, Nanjing 210001, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; Nanjing University of Chinese Medicine
RP Liu, Y; Yan, TH (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, Nanjing 210009, Peoples R China.; Ma, CH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.; Long, HY (corresponding author), Nanjing Univ TCM, Affiliated Hosp 3, Nanjing Municipal Hosp TCM, Nanjing 210001, Jiangsu, Peoples R China.
EM hongyan3128@163.com; liuyuyaoda@163.com; yantianhuabest@126.com;
   machunhuabest@126.com
RI ; zhou, rui/KZT-9353-2024; Su, Tianyuan/Y-7054-2019; Ma,
   Chunhua/NFS-9026-2025
OI Yan, Tianhua/0000-0001-6124-8630; 
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-002-01]
FX This work was supported by the National Twelve Five Major Drug Discovery
   Project (no. 2011ZX09102-002-01).
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NR 48
TC 101
Z9 108
U1 1
U2 77
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD APR
PY 2016
VL 103
BP 134
EP 142
DI 10.1016/j.neuropharm.2015.12.007
PG 9
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA DF1KO
UT WOS:000371098800012
PM 26690894
DA 2026-05-27
ER

PT J
AU Ariyanti, AD
   Sisjayawan, J
   Zhang, J
   Zhang, JQ
   Wang, GX
   Miyagishi, M
   Wu, SR
   Kasim, V
AF Ariyanti, Agnes Dwi
   Sisjayawan, Julita
   Zhang, Jing
   Zhang, Jian-Qi
   Wang, Gui-Xue
   Miyagishi, Makoto
   Wu, Shou-Rong
   Kasim, Vivi
TI Elevating VEGF-A and PDGF-BB secretion by salidroside enhances
   neoangiogenesis in diabetic hind-limb ischemia
SO ONCOTARGET
LA English
DT Article
DE hind-limb ischemia; diabetes; salidroside; skeletal muscle cells;
   angiogenesis
ID HYPOXIA-INDUCIBLE FACTOR; CRITICAL LIMB ISCHEMIA; FACTOR-I HIF-1;
   ANGIOGENIC FACTORS; PROMOTES NEOVASCULARIZATION; PROLYL HYDROXYLASES;
   INSULIN-RESISTANCE; IMPROVES PERFUSION; GROWTH-FACTOR; EXPRESSION
AB Hind-limb ischemia (HLI) is one of the major complication of diabetic patients. Angiogenesis potential in diabetic patients is severely disrupted, and the mechanism underlying it has not been fully elucidated, making it an obstacle for developing an efficient therapeutic angiogenesis strategy. Skeletal muscle cells, through their paracrine function, had been known to be critical for neoangiogenesis. Here we found that hyperglycemia upregulates the expression of skeletal muscle cells prolyl hydroxylase domain 3 (PHD3), which resulted in the decrease of the secretion of angiogenic factors, especially VEGF-A and PDGF-BB. We showed that treatment with salidroside, a small molecule drug, significantly suppresses PHD3 expression and increases VEGF-A and PDGF-BB secretion from skeletal muscle cells, which in turn enhances the proliferation and migration potentials of endothelial and smooth muscle cells. Finally, we demonstrated that intramuscular injection of salidroside into the ischemic hind limbs of diabetic HLI model mice could efficiently induce neoangiogenesis and blood perfusion recovery. Thus, our novel findings not only reveal the effects of hyperglycemia on the angiogenesis potential of skeletal muscle cells and the mechanism underlying it, but also provides a novel finding suggesting that salidroside might be a potential small molecule drug for diabetic HLI.
C1 [Ariyanti, Agnes Dwi; Sisjayawan, Julita; Zhang, Jing; Zhang, Jian-Qi; Wang, Gui-Xue; Wu, Shou-Rong; Kasim, Vivi] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.
   [Ariyanti, Agnes Dwi; Sisjayawan, Julita; Wang, Gui-Xue; Wu, Shou-Rong; Kasim, Vivi] State & Local Joint Engn Lab Vasc Implants, Chongqing 400044, Peoples R China.
   [Miyagishi, Makoto] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Mol Composite Med Res Grp, Tsukuba, Ibaraki 3058566, Japan.
   [Wu, Shou-Rong] Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing 400044, Peoples R China.
C3 Chongqing University; National Institute of Advanced Industrial Science
   & Technology (AIST); Chongqing University
RP Wu, SR; Kasim, V (corresponding author), Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Wu, SR; Kasim, V (corresponding author), State & Local Joint Engn Lab Vasc Implants, Chongqing 400044, Peoples R China.; Wu, SR (corresponding author), Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing 400044, Peoples R China.
EM shourongwu@cqu.edu.cn; vivikasim@cqu.edu.cn
RI Wang, Guixue/ACN-6343-2022; Kasim, Vivi/AID-0964-2022; Miyagishi,
   Makoto/L-8174-2016
OI Miyagishi, Makoto/0000-0001-7654-3616; Kasim, Vivi/0000-0001-9182-8230
FU National Natural Science Foundation of China [81372202, 31301119];
   Natural Science Foundation of Chongqing [cstc2014jcyjA10058]; State and
   Local Joint Engineering Laboratory for Vascular Implants; Fundamental
   Research Funds for the Central Universities [106112016CDJZR235516];
   Specialized Research Fund for the Doctoral Program of Higher Education
   of China [20130191120035]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81372202, 31301119), the Natural Science Foundation
   of Chongqing (cstc2014jcyjA10058), the Specialized Research Fund for the
   Doctoral Program of Higher Education of China (No. 20130191120035) and
   the Fundamental Research Funds for the Central Universities
   (106112016CDJZR235516). We also thank for the support from the State and
   Local Joint Engineering Laboratory for Vascular Implants.
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NR 64
TC 24
Z9 25
U1 0
U2 15
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD NOV 14
PY 2017
VL 8
IS 57
BP 97187
EP 97205
DI 10.18632/oncotarget.21907
PG 19
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FR9LK
UT WOS:000419395000068
PM 29228603
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hou, XR
   Zhang, ZD
   Cao, MY
   Du, YX
   Wang, XP
AF Hou, Xinrui
   Zhang, Zhendong
   Cao, Mingyuan
   Du, Yuxin
   Wang, Xiaoping
TI miR-1343-3p regulating OGDHL/PDHB-pyruvate glucose metabolic
   reprogramming against gastric cancer cell proliferation
SO DISCOVER ONCOLOGY
LA English
DT Article
DE Gastric cancer; Glucose metabolic reprogramming; miR-1343-3p; OGDHL;
   Salidroside
ID LACTATE; DEHYDROGENASE; GLYCOLYSIS; ACID
AB BackgroundGastric cancer (GC) is the main cause for cancer-related mortality in the world. Recent studies have confirmed that metabolic reprogramming plays a significant role in cancer progression. This study aims to further clarify the underlying mechanisms that the tumor suppressor miR-1343-3p exerts anti-gastric cancer effects via glucose metabolic reprogramming pathways.MethodsHigh-throughput sequencing combined with bioinformatics analysis predicted significantly differentially expressed miRNAs and target mRNAs after salidroside treatment. RNA-binding protein immunoprecipitation (RIP) was used to verify miRNA interaction with its downstream target protein, while co-immunoprecipitation (Co-IP) was applied to confirm downstream target proteins interaction. The IC50 of salidroside was determined by in vitro CCK-8 assay and colony formation experiment. qRT-PCR, Western blot, ELISA, and ATP detection were used to evaluate cancer cell proliferation, miRNA-mRNA expression and metabolite changes. Cancer cells were transfection with miR-1343-3p mimics or inhibitors, OGDHL-targeted siRNA (si-OGDHL), to verify the effects of salidroside against cancers. In vivo tumor-bearing nude mouse models after salidroside or miR-1343-3p agomir treatments were applied to analyze the targeted miRNA-mRNA molecules expression and metabolite changes.ResultsBioinformatics confirmed that tumor suppressor miR-1343-3p down-regulated OGDHL expression, a key alpha-ketoglutarate dehydrogenase complex subunit of TCA cycle. Our findings first verified that OGDHL interacted with PDHB, a key pyruvate dehydrogenase E1-beta subunit in gastric cancer. Both in vitro and in vivo experiments revealed that salidroside inhibited GC growth in a time and dose-dependent way through up-regulating tumor suppressor miR-1343-3p, down-regulating OGDHL expression, destabilizing PDHB protein homeostasis, reducing pyruvate oxidative decarboxylation, and decreasing acetyl-CoA and ATP production.ConclusionTumor suppressor miR-1343-3p inhibited gastric cancer cell proliferation by regulating OGDHL/PDHB-pyruvate glucose metabolism axis, which lay a better basis for targeted therapeutic strategy in cancers.
C1 [Hou, Xinrui; Zhang, Zhendong; Cao, Mingyuan; Du, Yuxin; Wang, Xiaoping] Xizang Minzu Univ, Sch Med, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
   [Hou, Xinrui; Zhang, Zhendong; Cao, Mingyuan; Du, Yuxin; Wang, Xiaoping] Xizang Minzu Univ, Key Lab High Altitude Hypoxia Environm & Life Hlth, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
C3 Xizang Minzu University; Xizang Minzu University
RP Wang, XP (corresponding author), Xizang Minzu Univ, Sch Med, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.; Wang, XP (corresponding author), Xizang Minzu Univ, Key Lab High Altitude Hypoxia Environm & Life Hlth, 6 Wenhui East Rd, Xianyang 712082, Shaanxi, Peoples R China.
EM xpwang@xzmu.edu.cn
FU Natural Science Basic Research Plan of Shaanxi Province
   [2025JC-YBMS-1088]; National Natural Science Foundation of China
   [82460515]; Graduate research innovation and practice projects of Xizang
   Minzu University [Y2025140]; Central Guidance on Local Science and
   Technology Development Fund of Xizang Autonomous Region [LSKJ202447];
   Key R&D Projects of Xianyang Municipal Science and Technology Programme
   [L2024-ZDYF-SF-0025]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 82460515), the Natural Science Basic Research Plan of
   Shaanxi Province (Grant No. 2025JC-YBMS-1088), the Central Guidance on
   Local Science and Technology Development Fund of Xizang Autonomous
   Region (Grant No. LSKJ202447), the Key R&D Projects of Xianyang
   Municipal Science and Technology Programme (Grant No.
   L2024-ZDYF-SF-0025) and the Graduate research innovation and practice
   projects of Xizang Minzu University (Grant No. Y2025140).
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NR 50
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
EI 2730-6011
J9 DISCOV ONCOL
JI Discov. Oncol.
PD DEC 20
PY 2025
VL 17
IS 1
AR 139
DI 10.1007/s12672-025-04298-x
PG 20
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Endocrinology & Metabolism
GA CM9DA
UT WOS:001669581900001
PM 41420718
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, T
   Yang, JY
   Lu, LL
AF Sun, Tong
   Yang, Jingyi
   Lu, Lili
TI Glycosylation and sugar variations in tyrosol yield promising
   prebiotic-like effects
SO CURRENT RESEARCH IN FOOD SCIENCE
LA English
DT Article
DE Tyrosol; Glycosylation; Salidroside; Tyrosol (3-galactoside; Gut
   microbiota; Metabolomics
ID GUT MICROBIOTA; HOST HEALTH; LACTOBACILLUS; SALIDROSIDE; FERMENTATION;
   FLAVONOIDS; METABOLISM; BACTERIA
AB Phenolics are common food constituents, and glycosylation enhances their physicochemical properties and biological activities. This study evaluated the prebiotic-like properties of tyrosol and its glycosides, including natural tyrosol (3-glucoside (salidroside) and artificially synthesized tyrosol (3-galactoside, in C57BL/6J mice. Both glycosides exhibited enhanced effects on probiotics compared to tyrosol. Salidroside stimulated Lactobacillus growth, while tyrosol (3-galactoside notably promoted Bifidobacteria proliferation. Akkermansia, a nextgeneration probiotic, was suppressed by tyrosol but increased by tyrosol (3-galactoside. Additionally, the (3-galactoside promoted the proliferation of mucus-degrading gut commensals and exhibited the strongest inhibition on certain disease-related genera. Moreover, metabolomic patterns varied between the tyrosol and glycoside groups, particularly in isoflavonoid biosynthesis, with isoflavonoids enriched in the glycoside groups. Glycosylation of tyrosol and variations in its sugar units led to differences in the specificity and abundance of gut bacteria and metabolites. Given its superior prebiotic functions, tyrosol (3-galactoside holds potential as a novel food additive.
C1 [Sun, Tong; Yang, Jingyi; Lu, Lili] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology
RP Lu, LL (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China.
EM lililu@hust.edu.cn
FU National Natural Science Foundation of China [32071473]
FX This work was supported by the National Natural Science Foundation of
   China (No. 32071473) . We also express our gratitude to the Medical
   Subcenter of the Analytical & Testing Center at Huazhong University of
   Science and Technology for NMR spectrum acquisition.
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NR 63
TC 2
Z9 2
U1 4
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9271
J9 CURR RES FOOD SCI
JI Curr. Res. Food Sci.
PY 2025
VL 11
AR 101206
DI 10.1016/j.crfs.2025.101206
EA SEP 2025
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 8AY5P
UT WOS:001584340200001
PM 41080798
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, P
   Li, LH
   Shi, Y
   Hu, NB
AF Jin, Ping
   Li, Liang-Hai
   Shi, Yan
   Hu, Nan-Bin
TI Salidroside inhibits apoptosis and autophagy of cardiomyocyte by
   regulation of circular RNA hsa_circ_0000064 in cardiac
   ischemia-reperfusion injury
SO GENE
LA English
DT Article
DE Salidroside; Cardiac ischemia-reperfusion injury; Circ-0000064;
   Autophagy; RAPA
ID ISCHEMIA/REPERFUSION INJURY; BIOMARKER; PATHWAY; STRESS; CELLS
AB Salidroside (Sal), a natural extract of Rhodiola rosea, shows a latent effect on protecting cardiovascular system. Our study explored the effect of salidroside on ischemia-reperfusion (I/R) injury in rat heart. I/R was performed on Wistar rat hearts, and Sal pretreatment was performed in I/R rats. Cardiac marker enzyme, myocardial infarct size, malondialdehyde (MDA) and superoxide dismutase (SOD) content were then measured. Compared with the untreated group, Sal pretreatment observably ameliorated the cardiac function, decreased the myocardial infarct size, reduced the levels of cardiac lactate creatine kinase-MB (CK-MB) and dehydrogenase (LDH), and inhibited the anti-oxidative stress. In addition, Sal treatment also significantly inhibited autophagy and apoptosis, which could be partially reversed by Rapamycin (RAPA), an autophagic agonist. Furthermore, Sal treatment attenuated autophagy by up-regulating the expression of hsa_circ_0000064 (circ-0000064) and Rapamycin (RAPA) treatment abolished it. Our study showed that Sal protected the heart from I/R injury, which might be related to the upregulation of circ-0000064 and the inhibition of autophagy.
C1 [Jin, Ping; Li, Liang-Hai] Yangtze Univ, Clin Med Coll 2, Jingzhou Cent Hosp, Dept Intens Care Unit ICU, Jingzhou, Hubei, Peoples R China.
   [Shi, Yan] Xuzhou Med Univ, Huaian Peoples Hosp 2, Dept Emergency, Huaian, Peoples R China.
   [Shi, Yan] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian, Peoples R China.
   [Hu, Nan-Bin] Lian Shui Peoples Hosp, Dept Intens Care Unit, Lian Shui, Huanan, Peoples R China.
C3 Yangtze University; Xuzhou Medical University; Xuzhou Medical University
RP Jin, P (corresponding author), Yangtze Univ, Clin Med Coll 2, Jingzhou Cent Hosp, Dept Intens Care Unit ICU, Jingzhou, Hubei, Peoples R China.
EM dr_jinping@163.com
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NR 30
TC 36
Z9 43
U1 0
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD JAN 30
PY 2021
VL 767
AR 145075
DI 10.1016/j.gene.2020.145075
PG 8
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA PG6WA
UT WOS:000599872500014
PM 32858179
DA 2026-05-27
ER

PT J
AU Duo, DZ
   Feng, Y
   Meng, XG
   Lv, Y
   Zhang, Y
   Pan, SY
AF Duo, Dazhi
   Feng, Yuan
   Meng, Xiangen
   Lv, Yan
   Zhang, Yu
   Pan, Shuyi
TI Combination of Salidroside and hyperbaric oxygen improves leukoaraiosis
   through P13K/Akt signaling
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Leukoaraiosis; salidroside; hyperbaric oxygen; P13K/Akt
ID DEMENTIA; THERAPY
AB Background: Leukoaraiosis (LA) is an abnormal change in appearance of white matter near the lateral ventricles. It is responsible for changes in memory, cognition and behavior. Salidroside is a drug responsible for the antidepressant and anxiolytic action. Hyperbaric oxygen therapy involves breathing pure oxygen in a pressurized room or tube. Thus, in this study the role of combination of Salidroside (Sal) and hyperbaric oxygen (HBO) on cognitive dysfunction in rats with LA was verified. Methods: Bilateral carotid artery of rat was ligated for 2 weeks in order to establish the model of cerebral ischemia and hypoxia. From the fifteenth days, the animals were given Sal or HBO or both for 2 weeks. LFB (Luxol fast blue stain) and MBP (myelin basic protein) staining were used to observe the changes of white matter myelin and oligodendrocytes, TUNEL was used to observe the apoptosis of oligodendrocytes and phosphor P13K/Akt signaling was assayed by Western blot. Results: We observed that myelin lesions as well as the number of apoptotic cells has increased and the proliferation of oligodendrocytes has decreased in the model group as compared to control group. Salidroside significantly alleviated the myelin and oligodendrocytes lesions and HBO inhibit the apoptosis of oligodendrocytes. Combination Sal and HBO had better effects on myelin and oligodendrocytes through promoting P13K/Akt (phosphoinositide-3 kinase) signaling pathway. Conclusion: Combination of Sal and HBO contributes to improvement of demyelination and survival of oligodendrocytes through P13K/Akt signaling.
C1 [Duo, Dazhi; Meng, Xiangen; Lv, Yan; Zhang, Yu; Pan, Shuyi] Navy Gen Hosp, Dept Hyperbar Oxygen, 6 Fu Cheng Rd, Beijing 100048, Peoples R China.
   [Feng, Yuan] Southern Med Univ, 1023-1063 Sha Tai Rd, Guangzhou 510515, Guangdong, Peoples R China.
C3 Sixth Medical Center of Chinese PLA General Hospital; Southern Medical
   University - China
RP Pan, SY (corresponding author), Navy Gen Hosp, Dept Hyperbar Oxygen, 6 Fu Cheng Rd, Beijing 100048, Peoples R China.
EM syp201002@sina.com
FU Capital Public Health project [Z141100002114039]; Beijing Nova Program
   [Z161100004916144]
FX The project was funded by Capital Public Health project
   (Z141100002114039) and Beijing Nova Program (Z161100004916144).
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NR 13
TC 1
Z9 1
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 5
BP 4730
EP 4735
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GI0AJ
UT WOS:000434031300042
DA 2026-05-27
ER

PT J
AU Elameen, A
   Kosman, VM
   Thomsen, M
   Pozharitskaya, ON
   Shikov, AN
AF Elameen, Abdelhameed
   Kosman, Vera M.
   Thomsen, Mette
   Pozharitskaya, Olga N.
   Shikov, Alexander N.
TI Variability of Major Phenyletanes and Phenylpropanoids in
   16-Year-OldRhodiola roseaL. Clones in Norway
SO MOLECULES
LA English
DT Article
DE bioactive compounds; cinnamyl alcohol; freeze-drying; HPLC; Rhodiola
   rosea; rosavin; rosin; salidroside; tyrosol
ID RHODIOLA-ROSEA L.; IN-VITRO INHIBITION; CHEMICAL-COMPOSITION;
   PHENYLPROPENOID CONTENT; SECONDARY METABOLITES; BIOACTIVE COMPOUNDS;
   HARVEST SEASON; GOLDEN ROOT; PLANT-PART; SALIDROSIDE
AB Rhodiola roseaL. (roseroot) is an adaptogen plant belonging to the Crassulaceae family. The broad spectrum of biological activity ofR. roseais attributed to its major phenyletanes and phenylpropanoids: rosavin, salidroside, rosin, cinnamyl alcohol, and tyrosol. In this study, we compared the content of phenyletanes and phenylpropanoids in rhizomes ofR. roseafrom the Norwegian germplasm collection collected in 2004 and in 2017. In general, the content of these bioactive compounds in 2017 was significantly higher than that observed in 2004. The freeze-drying method increased the concentration of all phenyletanes and phenylpropanoids in rhizomes compared with conventional drying at 70 degrees C. As far as we know, the content of salidroside (51.0 mg g(-1)) observed in this study is the highest ever detected inRhodiolaspp. Long-term vegetative propagation and high genetic diversity ofR. roseatogether with the freeze-drying method may have led to the high content of the bioactive compounds observed in the current study.
C1 [Elameen, Abdelhameed] Norwegian Inst Bioecon Res, NIBIO, Hoghskoleveien 7, N-1431 As, Norway.
   [Kosman, Vera M.] St Petersburg Inst Pharm, P 245, Kuzmolovo 188663, Leningrad Regio, Russia.
   [Thomsen, Mette] Norwegian Inst Bioecon Res, NIBIO, N-2849 Kapp, Norway.
   [Pozharitskaya, Olga N.] Russian Acad Sci MMBI RAS, Murmansk Marine Biol Inst, Vladimirskaya 17, Murmansk 183010, Russia.
   [Shikov, Alexander N.] St Petersburg State Chem Pharmaceut Univ, Prof Popov 14, St Petersburg 197376, Russia.
C3 Norwegian Institute of Bioeconomy Research; Norwegian Institute of
   Bioeconomy Research; Russian Academy of Sciences; Murmansk Marine
   Biological Institute
RP Elameen, A (corresponding author), Norwegian Inst Bioecon Res, NIBIO, Hoghskoleveien 7, N-1431 As, Norway.
EM abdelhameed.elameen@nibio.no; kosmanvm@mail.ru; mette.thomsen@nibio.no;
   olgapozhar@mail.ru; spb.pharmacy@gmail.com
RI Pozharitskaya, Olga/D-9671-2014; Kosman, Vera/ABG-6399-2021; Shikov,
   Alexander/B-1804-2008
OI Pozharitskaya, Olga/0000-0003-1061-0665; Elameen,
   Abdelhameed/0000-0002-4158-7923; Kosman, Vera/0000-0001-9690-1935;
   Shikov, Alexander/0000-0003-4351-0695
FU Norwegian Institute of Bioeconomy Research
FX The study was funded by Norwegian Institute of Bioeconomy Research.
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NR 68
TC 16
Z9 19
U1 0
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2020
VL 25
IS 15
AR 3463
DI 10.3390/molecules25153463
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NM4KN
UT WOS:000568067200001
PM 32751483
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mirmazloum, I
   Ladányi, M
   György, Z
AF Mirmazloum, Iman
   Ladanyi, Marta
   Gyoergy, Zsuzsanna
TI Changes in the Content of the Glycosides, Aglycons and their Possible
   Precursors of Rhodiola rosea during the Vegetation Period
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Rhodiola rosea; Roseroot; HPLC; Rosin; Rosavin; Rosarin; Tyrosol;
   Salidroside; Cinnamyl alcohol
ID BIOLOGICALLY-ACTIVE COMPOUNDS; L.; ROOTS
AB Phytochemical participants in the biosynthetic pathway of salidroside and cinnamyl alcohol glycosides were studied from seven Rhodiola rosea L. individuals originating from a wild population. Plants were grown in a phytotron and samples were taken at 3 weekly intervals during the vegetation period. Based on HPLC analysis, all the key compounds to which roseroot medicinal property is attributed were detected, with salidrosde being the most dominant, followed by its aglycone, tyrosol. The contents of all compounds were 2-3 times more in the rhizomes than in roots. The highest content of salidroside, tyrosol, rosarin, rosavin and cinnamyl alcohol was recorded in rhizomes and at the beginning of shoot elongation. The seven roseroot individuals showed a very high deviation in their chemical content at each sampling time. Our statistical analysis showed that the trend of salidroside accumulation in the rhizome was the most similar in all studied plants. These results have important implications for choosing a reasonable harvest time to obtain the maximum phytochemical content and a better understanding of active compounds formation in R. rosea L.
C1 [Mirmazloum, Iman; Gyoergy, Zsuzsanna] Corvinus Univ Budapest, Dept Genet & Plant Breeding, H-1518 Budapest, Hungary.
   [Ladanyi, Marta] Corvinus Univ Budapest, Dept Math & Informat, H-1518 Budapest, Hungary.
C3 Corvinus University Budapest; Corvinus University Budapest
RP Mirmazloum, I (corresponding author), Corvinus Univ Budapest, Dept Genet & Plant Breeding, POB 53, H-1518 Budapest, Hungary.
EM zsuzsanna.gyorgy@uni-corvinus.hu
RI György, Zsuzsanna/L-7105-2016; Ladanyi, Marta/AAX-9067-2021; Mirmazloum,
   Iman/AAJ-5673-2020
OI György, Zsuzsanna/0000-0002-7803-5487; Ladanyi,
   Marta/0000-0003-3114-8289; Mirmazloum, Iman/0000-0002-1461-0382
FU OTKA [PD83728.]; Corvinus University of Budapest; Hungarian Academy of
   Sciences;  [TAMOP- 4.2.1/B-09/1/KMR-2010-0005];  [TAMOP
   -4.2.2/B-10/1-2010-0023]
FX The research was supported by OTKA (PD83728.), TAMOP-
   4.2.1/B-09/1/KMR-2010-0005 and TAMOP -4.2.2/B-10/1-2010-0023. Zsuzsanna
   Gyorgy is grateful for the Award for Research Excellence of Corvinus
   University of Budapest and the Janos Bolyai Research Scholarship of the
   Hungarian Academy of Sciences.
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NR 21
TC 13
Z9 14
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD AUG
PY 2015
VL 10
IS 8
BP 1413
EP 1416
PG 4
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA CO3XY
UT WOS:000359095800025
PM 26434130
DA 2026-05-27
ER

PT J
AU Yang, SX
   Wang, LS
   Xie, ZP
   Zeng, Y
   Xiong, QW
   Pei, TT
   Wei, DF
   Cheng, WD
AF Yang, Sixia
   Wang, Linshuang
   Xie, Zeping
   Zeng, Yi
   Xiong, Qiaowu
   Pei, Tingting
   Wei, Dongfeng
   Cheng, Weidong
TI The Combination of Salidroside and Hedysari Radix Polysaccharide
   Inhibits Mitochondrial Damage and Apoptosis via the PKC/ERK Pathway
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID NEURONAL CELL-LINE; ALZHEIMERS-DISEASE; KINASE-C; BETA; IMPAIRMENT;
   ACTIVATION; MEDICINE; RECEPTOR; BURDEN
AB Background. Beta-amyloid (A beta) peptide is a widely recognized pathological marker of Alzheimer's disease (AD). Salidroside and Hedysari Radix polysaccharide (HRP) were extracted from Chinese herb medicine Rhodiola rosea L and Hedysarum polybotrys Hand-Mazz, respectively. The neuroprotective effects and mechanisms of the combination of salidroside and Hedysari Radix polysaccharide (CSH) against A beta(25-35) induced neurotoxicity remain unclear. Objective. This study aims to investigate the neuroprotective effects and pharmacological mechanisms of CSH on A beta(25-35)-induced HT22 cells. Materials and Methods. HT22 cells were pretreated with various concentrations of salidroside or HRP for 24h, followed by exposed to 20 mu m A beta(25-35) in the presence of salidroside or RHP for another 24h. In a CSH protective assay, HT22 cells were pretreated with 40 mu m salidroside and 20 mu g/mL HRP for 24h. The cell viability assay, cell morphology observation, determination of mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and cell apoptosis rate were performed. The mRNA expression of protein kinase C-beta (PKC beta), Bax, and Bcl-2 were measured by qRT-PCR. The protein expression levels of cleaved caspase-3, Cyt-C, PKC beta, phospho-ERK1/2, Bax, and Bcl-2 were measured by Western blot. Results. CSH treatment increased cell viability, MMP, and decreased ROS generation in A beta(25-35)-induced HT22 cells. PKC beta and Bcl-2 mRNA expression were elevated by CSH while Bax was decreased. CSH increased the protein expression levels of PKC beta, Bcl-2, and phospho-ERK1/2, and decreased those of Bax, Cyt-C, and cleaved caspase-3. Conclusions. CSH treatment have protective effects against A beta(25-35)-induced cytotoxicity through decreasing ROS levels, increasing MMP, inhibiting early apoptosis, and regulating PKC/ERK pathway in HT22 cells. CSH may be a potential therapeutic agent for treating or preventing neurodegenerative diseases.
C1 [Yang, Sixia; Xie, Zeping; Zeng, Yi; Xiong, Qiaowu; Pei, Tingting; Cheng, Weidong] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.
   [Wang, Linshuang; Wei, Dongfeng] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
C3 Southern Medical University - China; China Academy of Chinese Medical
   Sciences; Institute of Basic Research In Clinical Medicine, CACMS
RP Cheng, WD (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.; Wei, DF (corresponding author), China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
EM weidongfeng@aliyun.com; chengweidong888@sina.com
RI Cheng, Weidong/LMP-6222-2024
OI Wang, Linshuang/0000-0001-6081-4573
FU National Natural Science Foundation of China [81973641, 82174149,
   82174210]; National Key Research and Development Program of China
   [2018YFC1704400, 2018YFC170404]; Major National Science and Technology
   Projects Creation of Major New Drugs [2013ZX09103002-002]
FX ,is study was funded by the National Natural Science Foundation of China
   (grant numbers: 81973641, 82174149 and 82174210), the National Key
   Research and Development Program of China (grant number: 2018YFC1704400
   and 2018YFC170404), and the Major National Science and Technology
   Projects Creation of Major New Drugs (grant number: 2013ZX09103002-002).
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NR 57
TC 17
Z9 20
U1 3
U2 37
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUN 25
PY 2022
VL 2022
AR 9475703
DI 10.1155/2022/9475703
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3R1TM
UT WOS:000838702200004
PM 35795284
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Jiang, YR
   Mao, SQ
   Huang, WS
   Lu, BY
   Cai, ZX
   Zhou, F
   Li, MQ
   Lou, TT
   Zhao, YJ
AF Jiang, Yirong
   Mao, Shuqin
   Huang, Weisu
   Lu, Baiyi
   Cai, Zengxuan
   Zhou, Fei
   Li, Maiquan
   Lou, Tiantian
   Zhao, Yajing
TI Phenylethanoid Glycoside Profiles and Antioxidant Activities of
   Osmanthus fragrans Lour. Flowers by UPLC/PDA/MS and Simulated
   Digestion Model
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article; Proceedings Paper
CT 1st International Symposium on Phytochemicals in Medicine and Food
   (ISPMF)
CY JUN 26-29, 2015
CL Shanghai Normal Univ, Shanghai, PEOPLES R CHINA
SP Phytochem Soc Europe, Phytochem Soc Asia, Macau Univ Sci & Technol, Fujian Agr & Forestry Univ, Guizhou Med Univ, Yancheng Inst Technol, Beijing Normal Univ, Fudan Univ
HO Shanghai Normal Univ
DE Osmanthus fragrans Lour. flower; simulated digestion model; antioxidant
   capacity; UPLC/PDA/MS; phenylethanoid glycoside; acteoside; salidroside
ID IN-VITRO DIGESTION; VAR.-AURANTIACUS; PHENOLIC-ACIDS; UPLC-MS/MS; ASSAY;
   ANTHOCYANINS; CAPACITIES; EXTRACTS; CULTURE; TIME
AB Variations of phenylethanoid glycoside profiles and antioxidant activities:in Osmanthus fragrans flowers through the digestive tract were evaluated by a simulated digestion model and UPLC/PDA/MS. Major phenylethanoid glycosides and phenolic acids, namely, salidroside, acteoside, isoacteoside, chlorogenic acid, and caffeic acid, were identified in four cultivars of O. fragrans flowers, and the concentration of acteoside was the highest, being up to 71.79 mg/g dry weight. After simulated digestion, total phenylethanoid glycoside contents and antioxidant activities were significantly decreased. Acteoside was identified as decomposing into caffeic acid, whereas salidroside was found to be stable during simulated digestion. According to Pearson's correlation analysis, acteoside contents showed good correlations with antioxidant activities during simulated digestion (R-2 = 0.994, P < 0.01). In conclusion, acteoside was the major contributor to the antioxidant activity of O. fragrans flowers, and salidroside was considered as the major antioxidant compound of O. fragrans flowers in vivo.
C1 [Jiang, Yirong; Mao, Shuqin; Lu, Baiyi; Zhou, Fei; Li, Maiquan; Lou, Tiantian; Zhao, Yajing] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Fuli Inst Food Sci, Lab Qual & Safety Risk Assessment Agroprod Storag, Hangzhou 310058, Zhejiang, Peoples R China.
   [Huang, Weisu] Zhejiang Econ & Trade Polytech, Dept Appl Technol, Hangzhou 310018, Zhejiang, Peoples R China.
   [Cai, Zengxuan] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310051, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang Provincial Center for Disease Control &
   Prevention
RP Lu, BY (corresponding author), Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.
EM bylu@zju.edu.cn
RI Yang, Bowen/KWV-0501-2024
OI Jiang, Yirong/0000-0001-7070-4909
FU Zhejiang Provincial Natural Science Foundation of China [R15C200002];
   Foundation of Fuli Institute of Food Science, Zhejiang University;
   Special Project of Agricultural Product Quality Safety Risk Assessment
   [GJFP201502-3]; Ministry of Agriculture, China
FX This work was supported financially by the Zhejiang Provincial Natural
   Science Foundation of China (No. R15C200002), the Foundation of Fuli
   Institute of Food Science, Zhejiang University, and the Special Project
   of Agricultural Product Quality Safety Risk Assessment (No.
   GJFP201502-3), Ministry of Agriculture, China.
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NR 29
TC 41
Z9 45
U1 3
U2 130
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAR 30
PY 2016
VL 64
IS 12
BP 2459
EP 2466
DI 10.1021/acs.jafc.5b03474
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Agriculture; Chemistry; Food Science & Technology
GA DI5DM
UT WOS:000373519100004
PM 26322731
DA 2026-05-27
ER

PT J
AU Gui, D
   Cui, ZM
   Zhang, L
   Yu, C
   Yao, D
   Xu, M
   Chen, MY
   Wu, PL
   Li, GP
   Wang, LX
   Huang, XY
AF Gui, Di
   Cui, Zhimin
   Zhang, Lin
   Yu, Chang
   Yao, Dan
   Xu, Min
   Chen, Mayun
   Wu, Peiliang
   Li, Guoping
   Wang, Liangxing
   Huang, Xiaoying
TI Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle
   cell proliferation and apoptosis resistance by upregulating autophagy
   through the AMPK-mTOR-ULK1 pathway
SO BMC PULMONARY MEDICINE
LA English
DT Article
DE PASMCs; Hypoxia; Ampk; mTOR; ULK1; Autophagy
ID ACTIVATED PROTEIN-KINASE; IN-VIVO; AMPK; PHOSPHORYLATION; HYPERTENSION;
   MTOR; INHIBITION
AB Background: Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have shown that salidroside can exert protective effects against hypoxia-induced pulmonary arterial smooth muscle cell (PASMC) proliferation and apoptosis resistance through the AMPK pathway. This study aims to explore the relationship among AMPK, mTOR and ULK1 in PASMCs under hypoxic conditions and to investigate whether the protective effects of salidroside are related to the autophagic cell death pathway.
   Methods: Rat PASMCs were cultured and divided into five groups: the normoxia, hypoxia, hypoxia + MHY1485 (mTOR agonist), hypoxia + rapamycin (mTOR inhibitor) and hypoxia + salidroside groups. Hypoxic cells were treated as indicated for 24 h. Cell viability was evaluated by the CCK-8 assay. Cell apoptosis was measured by the TUNEL assay. The autophagy flux of PASMCs was evaluated with tandem mRFP-GFP fluorescence microscopy. Autophagosomes were detected by electron microscopy. Protein expression of LC3, p62, AMPK, P-AMPK (Thr 172), P-ULK1 (Ser 555 and Ser 317), mTOR, P-mTOR (Ser 2448), ULK1 and P-ULK1 (Ser 757) was detected by western blot assay.
   Results: PASMC proliferation and apoptosis resistance were observed under hypoxic conditions. Autophagy flux, the number of autophagosomes and the LC3II/LC3I ratio were increased in the hypoxia group compared with the normoxia group, whereas p62 expression was decreased. Treatment with rapamycin or salidroside reversed hypoxia-induced PASMC proliferation and apoptosis resistance and further increased autophagy flux, autophagosome levels and the LC3II/LC3I ratio but decreased p62 expression. Treatment with MHY1485 reversed hypoxia-induced PASMC apoptosis resistance and decreased autophagy flux as well as increased autophagosome levels, the LC3II/LC3I ratio and p62 expression. P-AMPK (Thr 172) and P-ULK1 (Ser 555) of the AMPK-ULK1 pathway were increased in the hypoxia group and were further increased in the salidroside group. Rapamycin and MHY1485 had no effect on either P-AMPK (Thr 172) or P-ULK1 (Ser 555). Phosphorylation of ULK1 at serine 317 did not significantly affect the five groups. Furthermore, P-mTOR (Ser 2448) and P-ULK1 (Ser 757) of the AMPK-mTOR-ULK1 pathway were decreased in the hypoxia group and were further decreased in the salidroside group. MHY1485 increased the expression of both P-mTOR(Ser 2448) and P-ULK1(Ser 757), whereas rapamycin had the opposite effect.
   Conclusions: Salidroside might inhibit hypoxia-induced PASMC proliferation and reverse apoptosis resistance via the upregulation of autophagy through both the AMPK alpha 1-ULK1 and AMPK alpha 1-mTOR-ULK1 pathways.
C1 [Gui, Di; Cui, Zhimin; Zhang, Lin; Yao, Dan; Xu, Min; Chen, Mayun; Wu, Peiliang; Wang, Liangxing; Huang, Xiaoying] Wenzhou Med Univ, Div Pulm Med, Key Lab Heart & Lung, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
   [Yu, Chang] Wenzhou Med Univ, Dept Invas Technol, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
   [Li, Guoping] Tongde Hosp Zhejiang Prov, Dept Resp Med, Hangzhou 310013, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Tongde Hospital
   of Zhejiang Province
RP Wang, LX; Huang, XY (corresponding author), Wenzhou Med Univ, Div Pulm Med, Key Lab Heart & Lung, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
EM wzyxywlx@163.com; zjwzhxy@126.com
OI Lai, Yichang/0009-0007-3727-8734
FU Chinese National Natural Science Foundation [81473406]; Natural Science
   Foundation of Zhejiang Province [Y17H010028]; Health Department of
   Zhejiang Province of China [2016DTA005]
FX This study was supported by the Chinese National Natural Science
   Foundation Grants (No. 81473406), the Natural Science Foundation of
   Zhejiang Province Grants (Y17H010028), and a project of the Health
   Department of Zhejiang Province of China (2016DTA005).
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PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2466
J9 BMC PULM MED
JI BMC Pulm. Med.
PD DEC 12
PY 2017
VL 17
AR 191
DI 10.1186/s12890-017-0477-4
PG 12
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA FQ1LX
UT WOS:000418120400001
PM 29233105
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, Y
   Jin, T
   Ryu, GH
AF Zhang, Yu
   Jin, Tie
   Ryu, Gi-Hyung
TI Physicochemical and antioxidant properties of extruded Rhodiola as
   affected by twin-screw extrusion
SO INTERNATIONAL JOURNAL OF FOOD PROPERTIES
LA English
DT Article
DE Rhodiola; Twin-screw extrusion; Operation parameters; Physicochemical
   characteristics; Antioxidant properties
ID FLOUR
AB In order to explore the effect of extrusion operating parameters on the physicochemical and antioxidation properties of the extruded Rhodiola, Rhodiola was extruded as raw material under different moisture content (24, 26, 28%), barrel temperature (120, 130, 140 degrees C) and screw speed (200, 250, 300 rpm) conditions. After extrusion, the water solubility index of Rhodiola was significantly higher than that of raw material, while the water absorption index was significantly lower than that of raw material. In addition, due to Maillard reaction, L* and a* values of color decreased significantly. The extraction rate of soluble substances, rhodioloside, total flavonoids and total phenols of Rhodiola rosea after extrusion were significantly higher (P ) than those of the raw material. Both moisture content and barrel temperature had important effects on the total phenolic content and antioxidant activity. At the same time, moisture content also significantly affected the rhodioloside content when the barrel temperature significantly affected the total flavonoid content. Whereas, the screw speed significantly affected the total flavonoid content. In conclusion, the extrusion process facilitated the increase of active ingredients of Rhodiola and significantly enhanced its antioxidant capacity.
C1 [Zhang, Yu; Ryu, Gi-Hyung] Kongju Natl Univ, Dept Food Sci & Technol, Yesan, South Korea.
   [Jin, Tie] Yanbian Univ, Dept Food Sci & Engn, Yanbian, Peoples R China.
C3 Kongju National University; Yanbian University
RP Ryu, GH (corresponding author), Kongju Natl Univ, Dept Food Sci & Technol, Yesan, South Korea.; Jin, T (corresponding author), Yanbian Univ, Dept Food Sci & Engn, Yanbian, Peoples R China.
EM jintie@ybu.edu.cn; ghryu@kongju.ac.kr
RI Zhang, Yu/MBG-1752-2025
OI Zhang, Yu/0000-0003-2938-2375
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Z9 8
U1 3
U2 41
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1094-2912
EI 1532-2386
J9 INT J FOOD PROP
JI Int. J. Food Prop.
PD DEC 31
PY 2023
VL 26
IS 1
BP 614
EP 627
DI 10.1080/10942912.2023.2174699
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 8S8TZ
UT WOS:000928848200001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, F
   Zhao, YJ
   Li, MQ
   Xu, T
   Zhang, LQ
   Lu, BY
   Wu, XD
   Ge, ZW
AF Zhou, Fei
   Zhao, Yajing
   Li, Maiquan
   Xu, Tao
   Zhang, Liuquan
   Lu, Baiyi
   Wu, Xiaodan
   Ge, Zhiwei
TI Degradation of phenylethanoid glycosides in Osmanthus fragrans
   Lour. flowers and its effect on anti-hypoxia activity
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ANTIOXIDANT ACTIVITY; PC12 CELLS; EXTRACT; VERBASCOSIDE; SALIDROSIDE;
   STABILITY; COMPOUND
AB This study was aimed at investigating the chemical stability (the thermal, light and pH stability) of phenylethanoid glycosides (PhGs) in Osmanthus fragrans Lour. flowers, identifying the degradation products of acteoside and salidroside (major PhGs in O. fragrans flowers) by UPLC-QTOF-MS and studying the anti-hypoxia activity of PhGs after degradation. The degradation of PhGs followed first-order reaction kinetics, and the rate constant of acteoside (4.3 to 203.4 x 10(-3) day(-1)) was higher than that of salidroside (3.9 to 33.3 x 10(-3) day(-1)) in O. fragrans flowers. Salidroside was mainly hydrolyzed to tyrosol during storage, and the degradation products of acteoside were verbasoside, caffeic acid, isoacteoside, etc. In a model of cobalt chloride (CoCl2)-induced hypoxia in PC12 cells, the anti-hypoxia ability of PhGs decreased after degradation, which resulted from the reduction of PhGs contents. Particularly, caffeic acid exhibited stronger anti-hypoxia ability than acteoside and could slightly increase the anti-hypoxia ability of degraded acteoside. The results revealed that high temperature, high pH and light exposure caused PhGs degradation, and thus the anti-hypoxia ability of PhGs reduced.
C1 [Zhou, Fei; Zhao, Yajing; Li, Maiquan; Xu, Tao; Zhang, Liuquan; Lu, Baiyi] Zhejiang Univ, Coll Biosyst Engn & Food Sci,Natl Engn Lab Intell, Key Lab Agroprod Postharvest Handling,Minist Agr, Zhejiang Key Lab Agrofood Proc,Fuli Inst Food Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Wu, Xiaodan; Ge, Zhiwei] Zhejiang Univ, Anal Ctr Agrobiol & Environm Sci, Hangzhou 310058, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Lu, BY (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci,Natl Engn Lab Intell, Key Lab Agroprod Postharvest Handling,Minist Agr, Zhejiang Key Lab Agrofood Proc,Fuli Inst Food Sci, Hangzhou 310058, Zhejiang, Peoples R China.
EM bylu@zju.edu.cn
RI ; Wu, Xiaodan/KZU-0311-2024; Yang, Bowen/KWV-0501-2024
OI Xu, Tao/0000-0002-7683-7785; 
FU Zhejiang Provincial Natural Science Foundation of China [R15C200002];
   National Major R & D Program of China [2017YFD0400200]; Special Project
   of Agricultural Product Quality Safety Risk Assessment, Ministry of
   Agriculture, China [GJFP2017015]
FX This study was supported by the Zhejiang Provincial Natural Science
   Foundation of China (No. R15C200002), the National Major R & D Program
   of China (No. 2017YFD0400200) and the Special Project of Agricultural
   Product Quality Safety Risk Assessment (No. GJFP2017015), Ministry of
   Agriculture, China.
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Z9 49
U1 5
U2 78
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 30
PY 2017
VL 7
AR 10068
DI 10.1038/s41598-017-10411-0
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FF0WS
UT WOS:000408622400162
PM 28855701
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, MH
   Wang, C
   Xu, YF
   Zhang, ZJ
   Wu, XY
   Ye, RF
   Zhang, QG
   Han, DH
AF Jin, Meihua
   Wang, Chun
   Xu, Yifeng
   Zhang, Zijing
   Wu, Xueyan
   Ye, Runfa
   Zhang, Qinggao
   Han, Donghe
TI Pharmacological effects of salidroside on central nervous system
   diseases
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Salidroside; Inflammation; Oxidative stress; Central nervous system
   disease
ID LUNG-CANCER CELLS; PARKINSONS-DISEASE; SIGNALING PATHWAY; INJURY;
   PROTECTS; INFLAMMATION; NEURONS; ACID; PROLIFERATION; CYTOTOXICITY
AB Salidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high altitudes. It has been proven to have protective effects on myocardial injury, liver cancer, renal fibrosis, and other organ diseases, as well as play neuroprotective roles in central nervous system (CNS) diseases. Specifically, SAL can inhibit a series of pathological reactions in CNS diseases and improve neurological dysfunction. This review elucidated the pharmacological effects of SAL on inflammation, oxidative stress, apoptosis, autophagy, and neuronal regener-ation. Furthermore, how SAL affects various signaling pathways to regulate pathological processes in CNS dis-eases is also assessed. However, the relationship between various pathways and the mechanisms in different pathological stages remains unclear. Additionally, the appropriate dosage and side effects of SAL on the clinical outcomes of CNS diseases have not been fully determined due to the limited number of clinical studies on SAL. Therefore, the regulatory mechanisms and clinical applications of SAL still need to be further demonstrated. This review tracked and summarized studies from the past eight years reported in databases, including PubMed, ScienceDirect, and Google Scholar, filtered using the keywords "salidroside" and/or paired with "diseases" and "CNS diseases".
C1 [Jin, Meihua; Wang, Chun; Xu, Yifeng; Zhang, Zijing; Wu, Xueyan; Ye, Runfa; Zhang, Qinggao; Han, Donghe] Dalian Univ, Med Coll, Chron Dis Res Ctr, Dalian 116622, Liaoning, Peoples R China.
   [Jin, Meihua; Wang, Chun; Xu, Yifeng; Zhang, Zijing; Wu, Xueyan; Ye, Runfa; Zhang, Qinggao; Han, Donghe] Dalian Univ, Engn Technol Res Ctr Utilizat Funct Components Org, Dalian 116622, Liaoning, Peoples R China.
C3 Dalian University; Dalian University
RP Zhang, QG; Han, DH (corresponding author), Dalian Univ, Med Coll, Chron Dis Res Ctr, Dalian 116622, Liaoning, Peoples R China.
EM annie_k611@hotmail.com; 744675835@qq.com; 1546310185@qq.com;
   934134089@qq.com; 1360824252@qq.com; 1169077230@qq.com;
   zqg0621@ybu.edu.cn; handonghe@foxmail.com
OI Zhang, Qing-Gao/0000-0002-7140-3822
FU Liaoning Provincial Education Department Scientific Research Fund,
   China; Dalian Science and Technology Innovation Fund, China; 
   [LJKZ1187];  [2020JJ27SN093]
FX Acknowledgments The authors heartly thank to Mrs. Wei for the kind
   linguistic editing. This work was supported by Liaoning Provincial
   Education Department Scientific Research Fund, China (LJKZ1187) and
   Dalian Science and Technology Innovation Fund, China (2020JJ27SN093) .
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NR 126
TC 49
Z9 58
U1 5
U2 55
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2022
VL 156
AR 113746
DI 10.1016/j.biopha.2022.113746
EA OCT 2022
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 5R5XU
UT WOS:000874584000009
PM 36228376
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Rattan, S
   Warghat, AR
AF Rattan, Shiv
   Warghat, Ashish R.
TI Integration of biotechnological approaches for the production of
   phenylethanoids and phenylpropanoids in in vitro cultures
   of Rhodiola sp. a comprehensive review
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Review
DE Rhodiola species; Secondary metabolites; Precursor feeding; Genetic
   transformation; Sustainable production; Cell culture
ID CELL-SUSPENSION CULTURES; CINNAMYL ALCOHOL GLYCOSIDES; STANDARDIZED
   EXTRACT SHR-5; COMPACT CALLUS AGGREGATE; ROSEA L.; SALIDROSIDE
   PRODUCTION; PHENYLPROPENOID CONTENT; PHYTOCHEMICAL ANALYSIS; SECONDARY
   METABOLITES; ANTIOXIDANT ACTIVITY
AB Rhodiola L. is an herbaceous medicinal plant in the Crassulaceae family. Its raw extract, leaves, and roots have been used widely in traditional folk medicine in Asia and Europe. Salidroside, rosin, rosavin, and rosarin are commercially important specialized metabolites with a variety of biological potential such as adaptogenic, neuroprotection, immunomodulation, anti-inflammatory, antidepressant activity, and so on. Previous research has shown that Rhodiola sp. is extremely beneficial in asthenic conditions such as poor work performance, sleep complications, irritability, headaches, poor appetite, hypertension, and fatigue. Rhodiola sp. preparations have traditionally been used to treat conditions such as cerebral ischemia, neurodegenerative diseases, hypoxia, diabetes, and cancer. The key compounds responsible for these activities are thought to be phenylethanoids (salidroside, tyrosol) which are associated with other important metabolites such as phenylpropanoids (rosin, rosavin, and rosarin). Salidroside, rosin, rosarin, and rosavin is the most studied and potential metabolite in Rhodiola sp. The purpose of this review is to emphasize recent developments in phenylethanoids and phenylpropanoids accumulation by utilizing numerous biotechnological interventions. Various methods for enhancing salidroside and rosavins (rosin, rosavin, and rosarin) levels in plant cells are discussed, including cell line se-lection, culture condition optimization, precursor feeding, elicitation, biotransformation, and metabolic engineering. Additionally, in order to accomplish the commercial demand, the requirements for consistent and sustainable production systems, together with future prospects, are also discussed.
C1 [Rattan, Shiv; Warghat, Ashish R.] CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
   [Rattan, Shiv; Warghat, Ashish R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR)
RP Warghat, AR (corresponding author), CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
EM ashishwarghat@hotmail.com
RI Warghat, Ashish/AAS-6726-2020
FU Council of Scientific and Industrial Research (CSIR) , Government of
   India [MLP-0201]; Department of Biotechnology (DBT) , Government of
   India [GAP-0225]; National Medicinal Plants Board (NMPB) , Government of
   India [GAP-0274]
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR) , Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection and utilization of
   Himalayan bioresources" (MLP-0201) , Department of Biotechnology (DBT) ,
   Government of India, under the project "Advanced Diploma Program in
   Plant Tissue Culture" (GAP-0225) and National Medicinal Plants Board
   (NMPB) , Government of India, "Development of Probiotics for Plant
   Tissue Culture; Boosting the performance of micro propagated plant
   materials by supplementing plant-associated useful endophytes"
   (GAP-0274) for providing financial support.
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NR 133
TC 5
Z9 6
U1 5
U2 32
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD DEC 15
PY 2023
VL 206
AR 117625
DI 10.1016/j.indcrop.2023.117625
EA OCT 2023
PG 15
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA X9FO0
UT WOS:001101428900001
OA hybrid
DA 2026-05-27
ER

PT J
AU Li, X
   Luo, BY
AF Li, Xia
   Luo, Benyan
TI Vasomotor tone regulation by Rhodiola in rat thoracic aorta
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Rhodiola; salidroside; aorta; vasoconstriction; vasorelaxation;
   vasomotor tone
ID POTASSIUM CHANNELS; IMBRICATA
AB Objective: This study was designed to investigate the effects of Rhodiola and one of its known active components, salidroside, on vasomotor tone regulation in rat isolated thoracic aorta and to explore the possible mechanisms. Materials and methods: Isometric tension was recorded from aortic rings in an organ bath for controlled drug application. To evaluate the influences of Rhodiola and salidroside on endothelial function, aortic rings with intact or denuded endothelium were always tested in parallel. Results: Salidroside (0.1-10.0 g/L) had no influence on the vasomotor tone of aortic rings, while Rhodiola evoked mechanistically distinct all-or-nothing responses at low and high doses. At a relatively low dose (0.1 g/L), Rhodiola induced endothelium-independent contraction of aortic rings at resting tension (P<0.01), a response dependent on extracellular Ca2+ and blocked by an L-type Ca2+ channel antagonist (P<0.01). At a higher dose (0.5 g/L), Rhodiola produced vasoconstriction at resting tension in Ca2+-free medium (P<0.01), a response inhibited by a protein kinase C (PKC) antagonist (P<0.05). Conversely, Rhodiola at the higher dose dilated aortic rings precontracted with phenylephrine (PE) (P<0.01), likely by inhibiting extracellular Ca2+ influx through PE-activated receptor-operated calcium channels (ROCCs) (P<0.01). Rhodiola had no significant influence on K+ channels of vascular smooth muscle cells or on endothelial vascular tension regulation. Conclusions: Rhodiola has mechanistically distinct dose-dependent effects on vascular tension in rat isolated thoracic aorta. However, these responses are produced by active ingredients other than salidroside.
C1 [Li, Xia; Luo, Benyan] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Neurol, 79 Qingchun Rd, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Li, X (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Neurol, 79 Qingchun Rd, Hangzhou 310006, Zhejiang, Peoples R China.
EM lix992@sina.cn
FU Zhejiang Provincial Natural Science Foundation of China [LY13H290001];
   Province Administration of Traditional Chinese Medicine, Zhejiang, P. R.
   China [2010ZB060]; National Natural Science Foundation of China
   [81500904]
FX This study was supported by the Zhejiang Provincial Natural Science
   Foundation of China (Grant No. LY13H290001), the Province Administration
   of Traditional Chinese Medicine, Zhejiang, P. R. China (No. 2010ZB060)
   and National Natural Science Foundation of China (No. 81500904). The
   authors are grateful to Tibet Rhodiola Pharmaceutical Holding Co., Ltd.
   for gifting Rhodiola.
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NR 17
TC 0
Z9 1
U1 0
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 12
BP 16499
EP 16505
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FR6XO
UT WOS:000419211000075
DA 2026-05-27
ER

PT J
AU Titomanlio, F
   Perfumi, M
   Mattioli, L
AF Titomanlio, Federica
   Perfumi, Marina
   Mattioli, Laura
TI Rhodiola rosea L. extract and its active compound salidroside
   antagonized both induction and reinstatement of nicotine place
   preference in mice
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Addiction; Conditioned place preference; Nicotine; Reinstatement;
   Rhodiola rosea L.; Salidroside; Stress; Locomotor activity
ID RELAPSE PREVENTION; STRESS; EXPRESSION; ACQUISITION; MECHANISMS;
   WITHDRAWAL; ADAPTOGENS; REWARD; REINFORCEMENT; VARENICLINE
AB Conventional pharmacological treatments for drug addiction aim to reduce three most important aspects: withdrawal syndrome, craving, and relapse. Pharmacological treatments currently available for the treatment of tobacco smoking are able to alleviate withdrawal symptoms but are not sufficiently effective in reducing craving and rarely effective to prevent relapse. Rhodiola rosea L., a well-known traditional oriental medicine with anxiolytic, antidepressive, antistress, and adaptogenic properties, has been recently shown to be effective in the prevention and treatment of nicotine-withdrawal symptoms.
   The present study used the conditioned place preference (CPP) model to systematically investigate, in mice, the effects of a R. rosea L. extract (RHO) and its active compound salidroside (SDS), on the reinforcing properties of nicotine and their efficacy in the vulnerability to reinstatement.
   To study the effects on the rewarding properties of nicotine, RHO (10, 15, and 20 mg/kg) and SDS (0.2 mg/kg) were tested both in the acquisition and expression of CPP induced by nicotine injection (0.5 mg/kg). Moreover, the efficacy of RHO and SDS in preventing relapse induced by nicotine priming (0.1 mg/kg, s.c.) and by restraint stress was also evaluated.
   Results showed the ability of RHO and salidroside to significantly reduce the rewarding properties of nicotine at all doses tested. RHO and SDS also suppressed both priming- and stress-induced reinstatement of CPP.
   The present study showed the positive effects of R. rosea L. in reducing rewarding properties and preventing relapse to nicotine and evidenced the important role of salidroside in the effects of the extract.
C1 [Titomanlio, Federica; Perfumi, Marina; Mattioli, Laura] Univ Camerino, Sch Pharm, Pharmacognosy Unit, I-62032 Camerino, MC, Italy.
C3 University of Camerino
RP Mattioli, L (corresponding author), Univ Camerino, Sch Pharm, Pharmacognosy Unit, Via Madonna delle Carceri 9, I-62032 Camerino, MC, Italy.
EM laura.mattioli@unicam.it
RI Perfumi, Marina Cecilia/D-6218-2012
OI Perfumi, Marina Cecilia/0000-0002-3686-0577
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NR 63
TC 20
Z9 25
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD MAY
PY 2014
VL 231
IS 10
BP 2077
EP 2086
DI 10.1007/s00213-013-3351-y
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AG1HS
UT WOS:000335166500004
PM 24264566
DA 2026-05-27
ER

PT J
AU You, BY
   Dun, YS
   Fu, SQ
   Qi, DK
   Zhang, WL
   Liu, Y
   Qiu, L
   Xie, MR
   Liu, SX
AF You, Baiyang
   Dun, Yaoshan
   Fu, Siqian
   Qi, Dake
   Zhang, Wenliang
   Liu, Yuan
   Qiu, Ling
   Xie, Murong
   Liu, Suixin
TI The Treatment of Rhodiola Mimics Exercise to Resist High-Fat
   Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; SIRT1; atrogenes; mitochondrion; rhodiola
AB Muscle dysfunction is a complication of high-fat diet (HFD)-induced obesity that could be prevented by exercise, but patients did not get enough therapeutic efficacy from exercise due to multiple reasons. To explore alternative or supplementary approaches to prevent or treat muscle dysfunction in individuals with obesity, we investigated the effects of Rhodiola on muscle dysfunction as exercise pills. SIRT1 might suppress atrogenes expression and improve mitochondrial quality control, which could be a therapeutic target stimulated by exercise and Rhodiola, but further mechanisms remain unclear. We verified the lipid metabolism disorders and skeletal muscle dysfunction in HFD feeding mice. Moreover, exercise and Rhodiola were used to intervene mice with a HFD. Our results showed that exercise and Rhodiola prevented muscle atrophy and dysfunction in obese mice and activating the SIRT1 pathway, while atrogenes were suppressed and mitochondrial quality control was improved. EX-527, SIRT1 inhibitor, was used to validate the essential role of SIRT1 in salidroside benefit. Results of cell culture experiment showed that salidroside alleviated high palmitate-induced atrophy and mitochondrial quality control impairments, but these improvements of salidroside were inhibited by EX-527 in C2C12 myotubes. Overall, Rhodiola mimics exercise that activates SIRT1 signaling leading to improvement of HFD-induced muscle dysfunction.
C1 [You, Baiyang; Dun, Yaoshan; Fu, Siqian; Zhang, Wenliang; Liu, Yuan; Qiu, Ling; Xie, Murong; Liu, Suixin] Cent South Univ, Dept Phys Med & Rehabil, Xiangya Hosp, Div Cardiac Rehabil, Changsha, Peoples R China.
   [You, Baiyang; Dun, Yaoshan; Liu, Suixin] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
   [Dun, Yaoshan] Mayo Clin, Dept Cardiovasc Med, Div Prevent Cardiol, Rochester, MN 55901 USA.
   [Qi, Dake] Univ Manitoba, Coll Pharm, Winnipeg, MB, Canada.
C3 Central South University; Central South University; Mayo Clinic;
   University of Manitoba
RP Dun, YS; Liu, SX (corresponding author), Cent South Univ, Dept Phys Med & Rehabil, Xiangya Hosp, Div Cardiac Rehabil, Changsha, Peoples R China.; Dun, YS; Liu, SX (corresponding author), Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.; Dun, YS (corresponding author), Mayo Clin, Dept Cardiovasc Med, Div Prevent Cardiol, Rochester, MN 55901 USA.
EM liusuixin@csu.edu.cn; dunyaoshan@csu.edu.cn
RI Dun, Yaoshan/GOH-2956-2022; Liu, Suixin/GOH-2956-2022
OI Dun, Yaoshan/0000-0001-8642-9024; Liu, Suixin/0000-0001-7621-0096; Liu,
   Suixin/0000-0001-7621-0096
FU National Natural Science Foundation of China [81672262, 82002403,
   81702241]; Natural Science Foundation of Hunan Province [2018JJ3847];
   National Development and Reform Commission [201201521]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Grant number 81672262 to SL, 82002403 to YD, and
   81702241 to YL), the Natural Science Foundation of Hunan Province (Grant
   number 2018JJ3847 to YL), and the National Development and Reform
   Commission (No. (201201521 to SL).
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NR 37
TC 14
Z9 16
U1 1
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 15
PY 2021
VL 12
AR 646489
DI 10.3389/fphar.2021.646489
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RU6RM
UT WOS:000645273100001
PM 33935745
OA Green Submitted, gold
DA 2026-05-27
ER

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   Yang, Yumin
TI Synthesis and protective effects of aralkyl alcoholic
   2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation
   induced apoptosis in PC12 cell
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Salidroside; N-Acetylglucosamine; PC12 cell; Hypoglycemia and serum
   limitation; Apoptosis; Cerebral ischemic
ID OXIDATIVE STRESS; SALIDROSIDE; EXPRESSION; MODEL
AB Neuroprotective agents have been in the focus of attention in the treatment of ischemic stroke. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., possessed a wide range of biological activities, especially neuroprotection. In an attempt to improve neuroprotective effects of new salidroside analogs for ischemic stroke, a series of novel aralkyl alcoholic 2-acetamido-2-deoxy-beta-D-pyranosides were synthesized and their protective activities against the hypoglycemia and serum limitation induced cell death in rat pheochromocytoma cells (PC12 cells) were studied. Most compounds showed strong neuroprotective effects, especially for 4g and 4h, which exhibited a great potency superior to salidroside. MTT assay, Hoechst 33342 staining, and flow cytometry with annexin V/PI staining collectively showed that pretreatment with 4g and 4h attenuated cell viability loss and apoptotic cell death in cultured PC12 cells. Caspase-3 colorimetric assay and Rhodamine 123 staining revealed the changes in expression levels of caspase-3 and mitochondrial membrane potential in PC12 cells on exposure to hypoglycemia and serum limitation with and without 4g and 4h pretreatment, respectively. All the results suggested that 4g and 4h protects the PC12 cells against hypoglycemia and serum limitation induced apoptosis possibly by modulation of apoptosis-related gene expression and restoration of the mitochondrial membrane potential. Therefore, these novel findings may provided a new framework for the design of new aralkyl alcoholic 2-acetamido-2-deoxy-beta-D-pyranosides as neuroprotective agents for treating cerebral ischemic stroke and neurodegenerative diseases. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Meng, Ying; Guo, Yibing; Zhao, Yahong; Zhang, Qi; Zhou, Xinyang; Ding, Fei; Yang, Yumin] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
   [Guo, Yibing] Nantong Univ, Affiliated Hosp, Surg Comprehens Lab, Nantong 226001, Jiangsu, Peoples R China.
   [Ling, Yong] Nantong Univ, Sch Med, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM yangym@ntu.edu.cn
RI ; DING, FEI/KLD-8925-2024; yang, zhou/MFI-8086-2025; Zhao,
   Yahong/JFA-2536-2023
OI Guo, Yibing/0000-0001-9723-0678; 
FU Hi-Tech Research and Development Program of China (863 Program)
   [2006AA02A128]; Nature Science Foundation of China [30970713]; Basic
   Research Program of Jiangsu Province [BK2009518]; Priority Academic
   Program Development of Jiangsu Higher Education Institutions
FX The financial supports of Hi-Tech Research and Development Program of
   China (863 Program, Grant no. 2006AA02A128), Nature Science Foundation
   of China (Grant no. 30970713), Basic Research Program of Jiangsu
   Province (Grant no. BK2009518) and the Priority Academic Program
   Development of Jiangsu Higher Education Institutions are gratefully
   acknowledged.
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NR 29
TC 20
Z9 22
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD SEP 15
PY 2011
VL 19
IS 18
BP 5577
EP 5584
DI 10.1016/j.bmc.2011.07.031
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 817XO
UT WOS:000294711100030
PM 21855355
DA 2026-05-27
ER

PT J
AU Lu, XY
   Lai, MY
   Qin, P
   Zheng, YC
   Liao, JY
   Zhang, ZJ
   Xu, JH
   Yu, HL
AF Lu, Xin-Yi
   Lai, Ming-Yuan
   Qin, Peng
   Zheng, Yu-Cong
   Liao, Jia-Yi
   Zhang, Zhi-Jun
   Xu, Jian-He
   Yu, Hui-Lei
TI Facilitating secretory expression of apple seed β-glucosidase in
   Komagataella phaffii for the efficient preparation of salidroside
SO BIOTECHNOLOGY JOURNAL
LA English
DT Article
DE beta-glucosidase; directed evolution; Komagataella phaffii; salidroside;
   secretory expression
ID D-GLUCOPYRANOSIDES; ENZYMATIC-SYNTHESIS; PROTEIN; PURIFICATION;
   IDENTIFICATION; GLUCOSYLATION; OPTIMIZATION; GLYCOSIDASE; EXTRACTION;
   COSOLVENT
AB Plant-derived beta-glucosidases hold promise for glycoside biosynthesis via reverse hydrolysis because of their excellent glucose tolerance and robust stability. However, their poor heterologous expression hinders the development of large-scale production and applications. In this study, we overexpressed apple seed beta-glucosidase (ASG II) in Komagataella phaffii and enhanced its production from 289 to 4322 U L-1 through expression cassette engineering and protein engineering. Upon scaling up to a 5-L high cell-density fermentation, the resultant mutant ASG IIV80A achieved a maximum protein concentration and activity in the secreted supernatant of 2.3 g L-1 and 41.4 kU L-1, respectively. The preparative biosynthesis of salidroside by ASG IIV80A exhibited a high space-time yield of 33.1 g L-1 d(-1), which is so far the highest level by plant-derived beta-glucosidase. Our work addresses the long-standing challenge of the heterologous expression of plant-derived beta-glucosidase in microorganisms and presents new avenues for the efficient production of salidroside and other natural glycosides.
C1 [Lu, Xin-Yi; Lai, Ming-Yuan; Qin, Peng; Zheng, Yu-Cong; Liao, Jia-Yi; Zhang, Zhi-Jun; Xu, Jian-He; Yu, Hui-Lei] East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
C3 East China University of Science & Technology
RP Yu, HL (corresponding author), East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
EM huileiyu@ecust.edu.cn
RI liao, jiayi/OOL-4725-2025; Zhang, Zhi-Jun/D-6064-2016
FU National Natural Science Foundation of China [32271540]; Program of
   Shanghai Academic Research Leader [21XD1400800]; National Key Research
   and Development Program of China [2019YFA09005000, 2021YFC2102900];
   Fundamental Research Funds for the Central Universities [22221818014]
FX National Natural Science Foundation of China, Grant/Award Number:
   32271540; Program of Shanghai Academic Research Leader, Grant/Award
   Number: 21XD1400800; National Key Research and Development Program of
   China, Grant/Award Numbers: 2019YFA09005000, 2021YFC2102900; Fundamental
   Research Funds for the Central Universities, Grant/Award Number:
   22221818014
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NR 66
TC 4
Z9 4
U1 9
U2 36
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1860-6768
EI 1860-7314
J9 BIOTECHNOL J
JI Biotechnol. J.
PD AUG 21
PY 2024
VL 19
IS 8
AR e2400347
DI 10.1002/biot.202400347
PG 9
WC Biochemical Research Methods; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA D3N3N
UT WOS:001295282300001
PM 39167556
DA 2026-05-27
ER

PT J
AU Guo, YB
   Zhao, YH
   Zheng, C
   Meng, Y
   Yang, YM
AF Guo, Yibing
   Zhao, Yahong
   Zheng, Cheng
   Meng, Ying
   Yang, Yumin
TI Synthesis, Biological Activity of Salidroside and Its Analogues
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE salidroside; analogue;
   3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method;
   hypoglycemia and serum limitation; PC12 cell
AB Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel sandroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl beta-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl beta-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 mu mol/l and 60 mu mol/l, respectively.
C1 [Guo, Yibing; Zhao, Yahong; Meng, Ying; Yang, Yumin] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China.
   [Zheng, Cheng] Nantong Univ, Inst Naut Med, Nantong 226001, Jiangsu, Peoples R China.
   [Guo, Yibing] Nantong Univ, Sch Med, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
RI ; Zhao, Yahong/JFA-2536-2023
OI Guo, Yibing/0000-0001-9723-0678; 
FU Hi-Tech Research and Development Program of China (863 Program)
   [2006AA02A128]; Nature Science Foundation of China [30970713]; Basic
   Research Program of Jiangsu Province [BK2009518]; Program for New
   Century Excellent Talents in University
FX The financial supports of Hi-Tech Research and Development Program of
   China (863 Program, Grant no 2006AA02A128), Nature Science Foundation of
   China (Grant no 30970713), Basic Research Program of Jiangsu Province
   (Grant no BK2009518) and Program for New Century Excellent Talents in
   University are gratefully acknowledged
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NR 13
TC 37
Z9 41
U1 1
U2 38
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD DEC
PY 2010
VL 58
IS 12
BP 1627
EP 1629
DI 10.1248/cpb.58.1627
PG 3
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 688ON
UT WOS:000284860800014
PM 21139267
OA Bronze
DA 2026-05-27
ER

PT J
AU Saunders, D
   Poppleton, D
   Struchkov, A
   Ireland, R
AF Saunders, David
   Poppleton, Daniel
   Struchkov, Anton
   Ireland, Robert
TI Analysis of five bioactive compounds from naturally occurring
   Rhodiola rosea in eastern Canada
SO CANADIAN JOURNAL OF PLANT SCIENCE
LA English
DT Article
DE Rhodiola rosea; nutraceuticals; salidroside; Canada
ID BIOLOGICALLY-ACTIVE COMPOUNDS; MEDICINAL-PLANTS; SALIDROSIDE; RHIZOMES;
   ROOTS
AB The plant Rhodiola rosea produces several bioactive compounds including salidroside, tyrosol, rosarin, rosavin, and rosin. These compounds have been used in traditional medicinal practices in Asia and are currently found in many nutraceutical mixtures. The nutraceutical qualities of these five compounds has resulted in over harvesting of natural populations of R. rosea and instigated several industrial cultivation operations. The purpose of this study was to examine R. rosea from five distinct natural populations in the maritime provinces of Canada to determine the concentrations of these five bioactive compounds. Ten samples were obtained from each of five sites and the concentration of each compound in the rhizomes was determined. Reverse phase-HPLC with a diode array detector was used to quantify the five compounds extracted from plant samples. The concentrations of salidroside were found to be as high as 1.76% of total dry weight, tyrosol 0.28%, rosarin 1.1%, rosavin 2.14%, and rosin 0.31%. To the best of our knowledge, this is one of the first studies to determine rhizomal concentrations of the five bioactive compounds in natural Canadian samples of R. rosea.
C1 [Saunders, David; Poppleton, Daniel] Mt Allison Univ, Dept Chem & Biochem, Sackville, NB E4L 1G8, Canada.
   [Struchkov, Anton] Twelve Moons Ltd, Fergusons Cove, NS B3V 1L7, Canada.
   [Ireland, Robert] Mt Allison Univ, Dept Biol, Sackville, NB E4L 1G7, Canada.
C3 Mount Allison University; Mount Allison University
RP Saunders, D (corresponding author), Mt Allison Univ, Dept Chem & Biochem, Sackville, NB E4L 1G8, Canada.
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NR 21
TC 19
Z9 22
U1 0
U2 37
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4220
EI 1918-1833
J9 CAN J PLANT SCI
JI Can. J. Plant Sci.
PD MAY
PY 2014
VL 94
IS 4
BP 741
EP 748
DI 10.4141/CJPS2013-177
PG 8
WC Agronomy; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Plant Sciences
GA CA8EX
UT WOS:000349150900015
OA Bronze
DA 2026-05-27
ER

PT J
AU Zhao, Q
   Shi, J
   Chen, SY
   Hao, DD
   Wan, S
   Niu, HM
   Zhang, YQ
AF Zhao, Qin
   Shi, Jing
   Chen, Siyuan
   Hao, Doudou
   Wan, Sha
   Niu, Haomeng
   Zhang, Yongqun
TI Salidroside Affects Gut Microbiota Structure in db/db Mice by Affecting
   Insulin, Blood Glucose and Body Weight
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE salidroside; db; db mice; T2DM; intestinal microbiota
ID INTESTINAL MICROBIOTA; DIABETES-MELLITUS; OBESITY
AB Purpose: The purpose of this study was to investigate the regulatory effect of salidroside on the intestinal flora of mice with type 2 diabetes (T2DM) and its protective effect in the body.Patients and Methods: We acclimated 8-week-old mice for 7 days, divided them into 4 groups, and continued dosing for 8 weeks. We recorded weekly blood glucose levels and body weight for each mouse. After the completion of the feeding cycle, the 16S rRNA of the intestinal flora in the mice was sequenced, and the insulin and C-peptide levels in each group of mice were measured. Four samples were taken from each group for liver and kidney section staining.Results: Our results showed that gut microbiota diversity and function were significantly different between the diabetic mice and healthy mice and that insulin levels, body weight, and blood glucose levels could significantly influence gut microbiota changes at the genus level. The gut microbiota diversity and function of db/db mice were also altered after salidroside administration. Salidroside could attenuate inflammatory damage, lipid accumulation and inflammatory changes in the diabetic liver, as well as diabetic kidney damage. Candidatus arthromitus and Odoribacter are important species of the microbiota during diabetes and may serve as potential therapeutic targets.Conclusion: Our investigation of the associated pathological conditions and fecal microbiota in db/db mice provides new insights into the pathogenesis of T2DM and provides implications for the diagnosis and treatment of T2DM.
C1 [Zhao, Qin; Shi, Jing; Chen, Siyuan; Hao, Doudou; Wan, Sha; Zhang, Yongqun] Hosp Chengdu Off Peoples Govt Tibetan Autonomous, Biobank, Chengdu, Sichuan, Peoples R China.
   [Niu, Haomeng] Tibet Univ, Med Sch, Lhasa, Tibet, Peoples R China.
   [Zhang, Yongqun] Hosp Chengdu Off Peoples Govt Tibetan Autonomous, Biobank, 20 Ximianqiao Rd, Chengdu 610041, Sichuan, Peoples R China.
C3 Xizang University
RP Zhang, YQ (corresponding author), Hosp Chengdu Off Peoples Govt Tibetan Autonomous, Biobank, 20 Ximianqiao Rd, Chengdu 610041, Sichuan, Peoples R China.
EM yongqun_zhang@163.com
RI Zhao, Qin/AAP-9101-2020
OI Zhao, Qin/0000-0002-3519-9190
FU Research Project of Sichuan Medical Association [S19072]; Natural
   Science Foundation of Tibet Autonomous Region [XZ202101ZR0101G]; Key
   Research Projects of Hospital of Chengdu Office of People's Government
   of Tibetan Autonomous Region [QH-1 (2019) -03]
FX Qin Zhao and Jing Shi should be considered co -first authors. This study
   was supported by Research Project of Sichuan Medical Association
   (S19072) ; Natural Science Foundation of Tibet Autonomous Region
   (XZ202101ZR0101G) ; Key Research Projects of Hospital of Chengdu Office
   of People's Government of Tibetan Autonomous Region (Hospital.C.T.)
   (QH-1 (2019) -03) . The samples are stored in Biobank of Hospital of
   Chengdu Office of People?s Government of Tibetan Autonomous Region.
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NR 53
TC 9
Z9 11
U1 1
U2 28
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 2619
EP 2631
DI 10.2147/DMSO.S372192
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4H2AV
UT WOS:000849684100001
PM 36060789
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, YT
   Li, ZY
   Qi, L
   Zhang, LL
   Gao, DD
   Liu, HZ
   Cao, QW
   Tian, CC
   Xia, Q
   Wang, Y
AF Jin, Yutong
   Li, Zhengyang
   Qi, Lin
   Zhang, Lingling
   Gao, Dandan
   Liu, Haizhao
   Cao, Qingwen
   Tian, Chenchen
   Xia, Qun
   Wang, Yue
TI The autocrine action of salidroside on osteoclast during
   osteoclastogenesis via hypoxia-inducible factor-1α pathway
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Salidroside; hypoxia-inducible factor-1 alpha; vascular endothelial
   growth factor; interleukin 6; angiopoietin-like 4; osteoclastogenesis
ID CARDIOVASCULAR EVENTS; INDUCED APOPTOSIS; CELLS; ACTIVATION; ALCOHOL
AB Background and objective: The objective of this study was to investigate the potential of salidroside (SAL) (a major active compound in Rhodiola rosea L.) in regulating osteoclast differentiation and function by modulating the HIF-1 alpha pathway and its downstream target genes. Methods: The expression of HIF-1 alpha and its downstream target genes was examined at both mRNA and protein levels in osteoclasts treated with SAL. Immunofluorescence analysis was performed to assess the nuclear translocation and transcriptional activity of HIF-1 alpha in response to SAL. MTT, flow cytometry, qPCR, TRAP staining and bone resorption assays were used to evaluate the potential effect of salidroside on osteoclasts. Results: SAL enhanced the expression of HIF-1 alpha and its downstream target genes in osteoclasts. Immunofluorescence analysis confirmed the facilitation of HIF-1 alpha nuclear translocation and transcriptional activity by SAL. In addition, SAL enhanced osteoclast viability, differentiation and bone resorption activity in an autocrine manner through HIF-1 alpha/VEGF, IL-6 and ANGPTL4 pathways. Conclusion: SAL promotes osteoclast proliferation, differentiation and bone resorption through HIF-1 alpha/VEGF, IL-6 and ANGPTL4 pathways.
C1 [Jin, Yutong; Zhang, Lingling; Gao, Dandan; Liu, Haizhao; Cao, Qingwen; Tian, Chenchen; Wang, Yue] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.
   [Li, Zhengyang] Tianjin Stomatol Hosp, Dept Orthodont, Tianjin, Peoples R China.
   [Qi, Lin] Characterist Med Ctr Chinese Peoples Armed Police, Dept Pharm, Tianjin, Peoples R China.
   [Xia, Qun] Tianjin First Cent Hoapital, Dept Orthopaed, Tianjin 300190, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin Medical
   University
RP Wang, Y (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.; Xia, Q (corresponding author), Tianjin First Cent Hoapital, Dept Orthopaed, Tianjin 300190, Peoples R China.
EM xiaqun6@163.com; wangyue6808@tjutcm.edu.cn
OI Wang, Yue/0000-0001-6457-575X
FU National Natural Science Foundation of China [81572852, 82104671]; Great
   Program of the Science Foundation of Tianjin [18JCZDJC33200];
   Heilongjiang Province Fund [LH2020H102]; Tianjin University of
   Traditional Chinese Medicine Talented Youth Program [XJS2023108];
   Ministry of Education "Chunhui plan" cooperative scientific research
   project [HLJ2019034]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Natural Science Foundation of China (Nos.
   81572852, 82104671), the Great Program of the Science Foundation of
   Tianjin (Nos. 18JCZDJC33200), Heilongjiang Province Fund (Nos.
   LH2020H102), Tianjin University of Traditional Chinese Medicine Talented
   Youth Program (Nos.XJS2023108), Ministry of Education "Chunhui plan"
   cooperative scientific research project (HLJ2019034).
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NR 45
TC 2
Z9 2
U1 2
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD JUL
PY 2024
VL 43
AR 09603271241269028
DI 10.1177/09603271241269028
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA E5A5Q
UT WOS:001303129200001
PM 39197164
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, D
   Cao, LH
   Wang, ZS
   Feng, HS
   Cai, X
   Xu, MT
   Li, ML
   Yu, N
   Yin, Y
   Wang, W
   Kang, J
AF Zhang, Dan
   Cao, Lihua
   Wang, Zhenshan
   Feng, Haoshen
   Cai, Xu
   Xu, Mingtao
   Li, Menglu
   Yu, Na
   Yin, Yan
   Wang, Wei
   Kang, Jian
TI Salidroside mitigates skeletal muscle atrophy in rats with cigarette
   smoke-induced COPD by up-regulating myogenin and down-regulating
   myostatin expression
SO BIOSCIENCE REPORTS
LA English
DT Article
ID OBSTRUCTIVE PULMONARY-DISEASE; ISCHEMIA-REPERFUSION INJURY; DYSFUNCTION;
   EMPHYSEMA; MASS; IDENTIFICATION; MECHANISMS; CACHEXIA; STRENGTH;
   DEFICITS
AB Objectives: The present study aimed at investigating the therapeutic effect of Salidroside on skeletal muscle atrophy in a rat model of cigarette smoking-induced chronic obstructive pulmonary disease (COPD) and its potential mechanisms.
   Methods: Male Wistar rats were randomized, and treated intraperitoneally (IP) with vehicle (injectable water) or a low, medium or high dose of Salidroside, followed by exposure to cigarette smoking daily for 16 weeks. A healthy control received vehicle injection and air exposure. Their lung function, body weights and gastrocnemius (GN) weights, grip strength and cross-section area (CSA) of individual muscular fibers in the GN were measured. The levels of TNF-alpha, IL-6, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) in serum and GN tissues as well as myostatin and myogenin expression in GN tissues were measured.
   Results: In comparison with that in the healthy control, long-term cigarette smoking induced emphysema, significantly impaired lung function, reduced body and GN weights and CSA values in rats, accompanied by significantly increased levels of TNF-alpha, IL-6 and MDA, but decreased levels of SOD and GSH in serum and GN tissues. Furthermore, cigarette smoking significantly up-regulated myostatin expression, but down-regulated myogenin expression in GN tissues. Salidroside treatment decreased emphysema, significantly ameliorated lung function, increased antioxidant, but reduced MDA, IL-6 and TNFF-alpha levels in serum and GN tissues of rats, accompanied by decreased myostain, but increased myogenin expression in GN tissues.
   Conclusion: Salidroside mitigates the long-term cigarette smoking-induced emphysema and skeletal muscle atrophy in rats by inhibiting oxidative stress and inflammatory responses and regulating muscle-specific transcription factor expression.
C1 [Zhang, Dan; Feng, Haoshen; Cai, Xu; Xu, Mingtao; Li, Menglu; Yu, Na; Yin, Yan; Wang, Wei; Kang, Jian] China Med Univ, Dept Resp Med, Affiliated Hosp 1, Inst Resp Dis, Shenyang 110001, Liaoning, Peoples R China.
   [Zhang, Dan; Cao, Lihua; Wang, Zhenshan] Dalian Med Univ, Dept Resp Med, Affiliated Hosp 2, Dalian 116000, Liaoning, Peoples R China.
C3 China Medical University; Dalian Medical University
RP Kang, J (corresponding author), China Med Univ, Dept Resp Med, Affiliated Hosp 1, Inst Resp Dis, Shenyang 110001, Liaoning, Peoples R China.
EM kangjian58@163.com
OI Li, Meng/0009-0006-9227-9441
FU National Key R&D Program of China [2016YFC1304500, 2018YFC1311600]
FX This work was supported by the National Key R&D Program of China [grant
   numbers 2016YFC1304500 and 2018YFC1311600].
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TC 25
Z9 27
U1 2
U2 13
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0144-8463
EI 1573-4935
J9 BIOSCIENCE REP
JI Biosci. Rep.
PD NOV 22
PY 2019
VL 39
AR BSR20190440
DI 10.1042/BSR20190440
PN 11
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JR6IH
UT WOS:000499726200001
PM 31702007
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, R
   Fang, CF
   Zhang, SJ
   Han, Z
   Zhu, GH
   Cai, SZ
   Zheng, C
   Tang, Y
   Wang, Y
AF Zhu, Rui
   Fang, Cui-fen
   Zhang, Shu-jing
   Han, Zhu
   Zhu, Ge-hui
   Cai, Shang-zuo
   Zheng, Cheng
   Tang, Yu
   Wang, Yi
TI Comprehensive Review on Rhodiola crenulata: Ethnopharmacology,
   Phytochemistry, Pharmacological Properties and Clinical Applications
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
ID QUALITY EVALUATION; EXTRACT; SALIDROSIDE; ACTIVATION; TOXICITY
C1 [Zhu, Rui; Zhang, Shu-jing; Zhu, Ge-hui; Cai, Shang-zuo; Tang, Yu; Wang, Yi] Zhejiang Univ, Pharmaceut Informat Inst, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China.
   [Zhu, Rui; Wang, Yi] Tianjin Univ Tradit Chinese Med, Tradit Chinese Med Res Ctr, Tianjin 300193, Peoples R China.
   [Fang, Cui-fen; Zheng, Cheng] Zhejiang Inst Food & Drug Control, Hangzhou 310057, Peoples R China.
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   [Han, Zhu; Wang, Yi] Zhejiang Univ, Innovat Ctr Yangtze River Delta, Natl Key Lab Chinese Med Modernizat, Jiaxing 314100, Zhejiang Provin, Peoples R China.
   [Zhu, Ge-hui] Zhejiang Univ, Innovat Inst Artificial Intelligence Med, Hangzhou 310018, Peoples R China.
   [Cai, Shang-zuo] Hangzhou Med Coll, Sch Pharm, Hangzhou 310012, Peoples R China.
C3 Zhejiang University; Tianjin University of Traditional Chinese Medicine;
   Zhejiang University; Zhejiang University; Hangzhou Medical College
RP Wang, Y (corresponding author), Zhejiang Univ, Pharmaceut Informat Inst, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China.; Wang, Y (corresponding author), Tianjin Univ Tradit Chinese Med, Tradit Chinese Med Res Ctr, Tianjin 300193, Peoples R China.; Wang, Y (corresponding author), Zhejiang Univ, Innovat Ctr Yangtze River Delta, Natl Key Lab Chinese Med Modernizat, Jiaxing 314100, Zhejiang Provin, Peoples R China.
EM zjuwangyi@zju.edu.cn
RI lianhua, xiayi/LKJ-7440-2024
FU National Natural Science Foundation of China [82204614, 82304755];
   Pioneer"and "Leading Goose" R&D Program of Zhejiang [2023C03004,
   2025C01110]
FX Supported by the National Natural Science Foundation of China (No.
   82204614 and No. 82304755), Pioneer"and "Leading Goose" R&D Program of
   Zhejiang (No. 2023C03004 and No. 2025C01110)
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NR 49
TC 3
Z9 4
U1 11
U2 20
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD AUG
PY 2025
VL 31
IS 8
BP 752
EP 759
DI 10.1007/s11655-025-4010-y
EA MAR 2025
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 5ZI0K
UT WOS:001451420400001
PM 40131609
DA 2026-05-27
ER

PT J
AU Sun, Q
   Zhang, L
   Huang, XY
   Wang, M
AF Sun, Qian
   Zhang, Li
   Huang, Xiuyan
   Wang, Min
TI Salidroside prevents gestational hypertension-induced impairment of
   offspring learning and memory via Wnt/Skp2 pathway
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Salidroside; Gestational hypertension; Learning; Memory; Offspring
ID BLOOD-PRESSURE; PREGNANCY; OUTCOMES; GROWTH; SKP2
AB Background: Salidroside (Sal) has been found to protect against multiple impairments caused by diabetes, and we designed this study to investigate the effect of Sal on gestational hypertension (GHP)-induced impairment of offspring learning and memory. Methods: We established a GHP rat model by intraperitoneal injection of NG-nitro-L-arginine methyl ester (LNAME), and treated with Sal by daily gavage. We used Morris Water Maze test to evaluate the learning and memory ability of offspring rats. HE staining was used to measured the pathological changes in hippocampus of offspring. Immunohistochemistry, cellular immunofluorescence and western blot were used to detect the protein expression. Results: The learning and memory abilities of GHP offspring rats were significantly lower than those of normal rat offspring, while Sal treatment could significantly improve the learning and memory abilities of GHP offspring rats. HE staining did not reveal pathological differences in the hippocampus of normal rats, GHP rats and Saltreated GHP offspring rats. However, Sal treatment can significantly increase the expression of Wnt1 and Skp2 protein, and decrease the expression of P27kiwf and P21waf1 protein in the hippocampus of GHP offspring rats. In vitro, Sal significantly promoted the proliferation and differentiation on neural stem cell, while Wnt1 knockdown could reverse these promotions by Sal. In the hippocampus of GHP offspring rats, Sal treatment significantly increased the expression of Tuj1, SOX2, Ki67 and DCX protein. Conclusion: Salidroside significantly improves the learning and memory impairment of offspring caused by GHP, and its mechanism may be related to the fact that Salidroside promotes the proliferation and differentiation of neural stem cells by activating the Wnt1/Skp2 signaling pathway.
C1 [Sun, Qian; Zhang, Li; Huang, Xiuyan; Wang, Min] Shandong First Med Univ Jinan, Jinan Matern & Child Care Hosp, Dept Gynaecol & Obstet, Jinan 250001, Shandong, Peoples R China.
RP Wang, M (corresponding author), Shandong First Med Univ Jinan, Jinan Matern & Child Care Hosp, Dept Gynaecol & Obstet, Jinan 250001, Shandong, Peoples R China.
EM wangm690@hotmail.com
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NR 48
TC 1
Z9 1
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 29
PY 2024
VL 832
AR 137787
DI 10.1016/j.neulet.2024.137787
EA MAY 2024
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA YA9K1
UT WOS:001265880100001
PM 38641312
DA 2026-05-27
ER

PT J
AU Fan, B
   Chen, TY
   Zhang, S
   Wu, B
   He, BF
AF Fan, Bo
   Chen, Tianyi
   Zhang, Sen
   Wu, Bin
   He, Bingfang
TI Mining of efficient microbial UDP-glycosyltransferases by motif
   evolution cross plant kingdom for application in biosynthesis of
   salidroside
SO SCIENTIFIC REPORTS
LA English
DT Article
ID GLYCOSIDES; ANTIOXIDANT; TYROSOL; FAMILY; CELLS
AB The plant kingdom provides a large resource of natural products and various related enzymes are analyzed. The high catalytic activity and easy genetically modification of microbial enzymes would be beneficial for synthesis of natural products. But the identification of functional genes of target enzymes is time consuming and hampered by many contingencies. The potential to mine microbe-derived glycosyltransferases (GTs) cross the plant kingdom was assessed based on alignment and evolution of the full sequences and key motifs of target enzymes, such as Rhodiola-derived UDP-glycosyltransferase (UGT73B6) using in salidroside synthesis. The GTs from Bacillus licheniformis ZSP01 with high PSPG motif similarity were speculated to catalyze the synthesis of salidroside. The UGT(BL)1, which had similarity (61.4%) PSPG motif to UGT73B6, displayed efficient activity and similar regioselectivity. Highly efficient glycosylation of tyrosol (1g/L) was obtained by using engineered E. coli harboring UGTBL1 gene, which generated 1.04 g/L salidroside and 0.99 g/L icariside D2. All glycosides were secreted into the culture medium and beneficial for downstream purification. It was the first report on the genome mining of UGTs from microorganisms cross the plant kingdom. The mining approach may have broader applications in the selection of efficient candidate for making high-value natural products.
C1 [Fan, Bo; Chen, Tianyi; Wu, Bin; He, Bingfang] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.
   [He, Bingfang] Nanjing Tech Univ, Sch Pharmaceut Sci, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.
   [Wu, Bin; He, Bingfang] Jiangsu Natl Synerget Innovat Ctr Adv Mat, 30 Puzhunan Rd, Nanjing, Jiangsu 211816, Peoples R China.
   [Zhang, Sen] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, 138 Xianlin Rd, Nanjing 210023, Peoples R China.
C3 Nanjing Tech University; Nanjing Tech University; Nanjing University of
   Chinese Medicine
RP He, BF (corresponding author), Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.; He, BF (corresponding author), Nanjing Tech Univ, Sch Pharmaceut Sci, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.; He, BF (corresponding author), Jiangsu Natl Synerget Innovat Ctr Adv Mat, 30 Puzhunan Rd, Nanjing, Jiangsu 211816, Peoples R China.
EM bingfanghe@njtech.edu.cn
FU National Natural Science Foundation of China [21376119, 81673321,
   21506099]; Specialized Research Fund for the Doctoral Program of Higher
   Education [20123221130001]; China Postdoctoral Science Foundation
   [2015M580420]
FX This work was supported by the National Natural Science Foundation of
   China (21376119, 81673321, 21506099), and Specialized Research Fund for
   the Doctoral Program of Higher Education (20123221130001), and China
   Postdoctoral Science Foundation (2015M580420).
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NR 40
TC 38
Z9 48
U1 9
U2 137
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 28
PY 2017
VL 7
AR 463
DI 10.1038/s41598-017-00568-z
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EP6YT
UT WOS:000397525500012
PM 28352078
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chang, XY
   Luo, F
   Jiang, WJ
   Zhu, LP
   Gao, J
   He, H
   Wei, TT
   Gong, SL
   Yan, TH
AF Chang, Xiayun
   Luo, Fen
   Jiang, Wenjiao
   Zhu, Lingpeng
   Gao, Jin
   He, He
   Wei, Tingting
   Gong, Shilin
   Yan, Tianhua
TI Protective activity of salidroside against ethanol-induced gastric ulcer
   via the MAPK/NF-κB pathway in vivo and in vitro
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Gastric ulcer; Ethanol; Inflammation; MAPKs/NF-kappa B
ID KINASE C-ZETA; GASTROPROTECTIVE ACTIVITY; SYNTHETIC SALIDROSIDE;
   OXIDATIVE DAMAGE; MUCOSAL DAMAGE; NITRIC-OXIDE; EXTRACT; INVOLVEMENT;
   CELL; ACTIVATION
AB Salidroside (Sal) is a traditional Chinese medicine with various pharmacological effects. The present study aimed to investigate the protective effect of Sal on-ethanol-induced acute gastric ulcer and H2O2-induced gastric epithelial cell damage. 0.2 ml ethanol and 400 mu M H2O2 were applied to establish a gastric ulcer model in vivo and in vitro respectively. The production of interleukin (IL)-6, interleuldn (IL)-1 beta and tumor necrosis factor (TNE)-alpha was analyzed, as well as myeloperoxidase (MPO), malondialdehyde (MDA) and superoxide dismutase (SOD). MIT assay was used to detect cell viability. In addition, MAPK/NF-kappa B signal pathway-related proteins p-ERK, p-JNK, p-p38, p-I kappa B alpha and p-NF-kappa Bp65 were analyzed to determine the underlying protective mechanism. Downstream genes such as cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and leukotrienes B-4 (LTB4) were also measured. Obtained data indicated that Sal inhibited the overproduction of pro-inflammatory cytokines and enhanced antioxidant activity. Collectively, it is assumed that Sal could alleviate ethanol-induced acute gastric ulcer and H2O2-induced gastric epithelial cell damage through the MAPK/NF-kappa B pathway. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Chang, Xiayun; Luo, Fen; Zhu, Lingpeng; Gao, Jin; He, He; Wei, Tingting; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
   [Jiang, Wenjiao; Gong, Shilin] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
EM yantianhuabest@126.com
RI Su, Tianyuan/Y-7054-2019; he, he/JPL-3505-2023
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-002-01]
FX This work was supported by National Twelve Five Major Drug Discovery
   Project (2011ZX09102-002-01).
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NR 42
TC 133
Z9 147
U1 1
U2 104
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD SEP
PY 2015
VL 28
IS 1
BP 604
EP 615
DI 10.1016/j.intimp.2015.07.031
PG 12
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA CR5VW
UT WOS:000361413500079
PM 26241782
DA 2026-05-27
ER

PT J
AU Hwang, YH
   Park, H
   Ma, JY
AF Hwang, Youn-Hwan
   Park, Hwayong
   Ma, Jin Yeul
TI In vitro and in vivo safety evaluation of Acer
   tegmentosum
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Acer tegmentosum; Salidroside; Genotoxicity; Acute toxicity
ID MUTAGENICITY; GENOTOXICITY; SALIDROSIDE; QUERCETIN; EXTRACT; ASSAY
AB Ethnopharmacological relevance: Acer tegmentosum, which contains salidroside and tyrosol, has been used for the treatment of hepatic disorders in eastern Asia. However, little is known about its safety. Aim of the study: To determine the safety of Acer tegmentosum, we evaluated its acute oral toxicity and genotoxicity profiles. Materials and methods: Salidroside and tyrosol present in Acer tegmentosum were quantified using high-performance liquid chromatography. Acute oral toxicity testing of Acer tegmentosum was performed in rats. Genotoxicity of Acer tegmentosum was assessed by bacterial reverse mutation, chromosomal aberration, and bone marrow micronucleus tests. All the tests were conducted in accordance with the good laboratory practices. Results: The amounts of salidroside and tyrosol in Acer tegmentosum were found to be 85.01 +/- 1.21 mg/g and 3.12 +/- 0.04 mg/g, respectively. In the bacterial reverse mutation test, Acer tegmentosum increased the number of revertant Salmonella typhimurium TA98 colonies, regardless of metabolic activation by S9 mixture. In contrast, Acer tegmentosum application did not significantly increase the number of chromosomal aberrations in Chinese hamster ovary (CHO)-K1 cells and micronucleated polychromatic erythrocytes in mice. In the acute oral toxicity test, the median lethal dose (LD50) of Acer tegmentosum was found to be > 2000 mg/kg in rats. Conclusion: Take together, Acer tegmentosum exhibits mutagenicity, which was evident from the bacterial reverse mutation test. Further studies are needed to identify the components responsible for such an effect and the underlying mechanisms. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Hwang, Youn-Hwan; Park, Hwayong; Ma, Jin Yeul] Korea Inst Oriental Med, KM Based Herbal Drug Res Grp, Taejon 305811, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Ma, JY (corresponding author), Korea Inst Oriental Med, KM Based Herbal Drug Res Grp, 1672 Yuseongdae Ro, Taejon 305811, South Korea.
EM jyma@kiom.re.kr
RI Hwang, Youn-Hwan/AAU-9373-2021
FU Korea Institute of Oriental Medicine [K13050]; Ministry of Education,
   Science and Technology (MEST), the Republic of Korea
FX This work was supported by the Grant (no. K13050) from the Korea
   Institute of Oriental Medicine funded by the Ministry of Education,
   Science and Technology (MEST), the Republic of Korea.
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NR 33
TC 23
Z9 26
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 21
PY 2013
VL 148
IS 1
BP 99
EP 105
DI 10.1016/j.jep.2013.03.074
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 174NP
UT WOS:000321163000012
PM 23602732
DA 2026-05-27
ER

PT J
AU Ogawa, Y
   Kawai, M
   Kinoshita, A
   Konishi, T
AF Ogawa, Y.
   Kawai, M.
   Kinoshita, A.
   Konishi, T.
TI Nitrogen-containing compounds from Hemerocallis fulva var.
   sempervirens
SO CHEMISTRY OF NATURAL COMPOUNDS
LA English
DT Article
DE Hemerocallis fulva var. sempervirens; kwansonine C; oxypinnatanine A
ID 2,5-DIHYDROFURYL-GAMMA-LACTAM DERIVATIVES; GLYCOSIDES
AB As part of our search for sedative substances derived from natural sources, two novel nitrogen compounds, kwansonine C (1) and oxypinnatanine A (2), and two novel salts of quinic acids (4) and (5) were isolated along with four known compounds, fulvanine A (3), icariside D2 (6), sallidroside (7), and (3S,4S)-3,4-dihydroxy-3-methyldihydrofuran-2-one (8), from Hemerocallis fulva L. var. sempervirens. These structures were elucidated by spectroscopic evidence and chemical methods.
C1 [Ogawa, Y.; Kawai, M.; Kinoshita, A.; Konishi, T.] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Kyoto 6100395, Japan.
RP Ogawa, Y (corresponding author), Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Kyoto 6100395, Japan.
EM yogawa@dwc.doshisha.ac.jp
FU Japan Society for the Promotion of Science [22590025]; Grants-in-Aid for
   Scientific Research [22590025] Funding Source: KAKEN
FX The authors thank Ms. Kayoko Oda, Kyoto Pharmaceutical University, and
   Professor Naoki Noda, Faculty of Pharmaceutical Sciences, Setsunan
   University, for measurements of FAB-MS. This work was supported by a
   Grant-in Aid for Scientific Research (C) (No. 22590025) from the Japan
   Society for the Promotion of Science.
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NR 10
TC 8
Z9 9
U1 0
U2 39
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-3130
EI 1573-8388
J9 CHEM NAT COMPD+
JI Chem. Nat. Compd.
PD JAN
PY 2014
VL 49
IS 6
BP 991
EP 995
DI 10.1007/s10600-014-0806-2
PG 5
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 303YY
UT WOS:000330713200001
DA 2026-05-27
ER

PT J
AU Potocká, EK
   Mastihubová, M
   Mastihuba, V
AF Potocka, Elena Karnisova
   Mastihubova, Maria
   Mastihuba, Vladimir
TI Enzymatic synthesis of tyrosol and hydroxytyrosol β-d-fructofuranosides
SO BIOCATALYSIS AND BIOTRANSFORMATION
LA English
DT Article
DE Tyrosol beta-d-fructofuranoside; hydroxytyrosol beta-d-fructofuranoside;
   salidroside; enzymatic transglycosylation
ID APPLE SEED; SALIDROSIDE
AB Tyrosol beta-d-fructofuranoside and hydroxytyrosol beta-d-fructofuranoside have been synthesized as new compounds in 27.6 and 19.5% respective yields through transfructosylation of tyrosol and hydroxytyrosol. Yeast beta-galactosidase Lactozym 3000 L comprising invertase activity was used as catalyst. Besides the main monofructosides, an equimolar mixture of tyrosol beta-d-fructofuranosyl-((2 -> 1)-beta-d-fructofuranoside and tyrosol beta-d-fructofuranosyl-(2 -> 6)-beta-d-fructofuranoside was isolated as additional product fraction in 14.3% yield.
C1 [Potocka, Elena Karnisova; Mastihubova, Maria; Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Institute of Chemistry, SAS
RP Mastihuba, V (corresponding author), Slovak Acad Sci, Inst Chem, Bratislava, Slovakia.
EM vladimir.mastihuba@savba.sk
RI Mastihubova, Maria/OZG-0746-2025; Mastihuba, Vladimír/S-7938-2017;
   Karnišová Potocká, Elena/AAU-9718-2021
OI Mastihubova, Maria/0000-0003-3033-811X; Mastihuba,
   Vladimír/0000-0003-2587-2553; Karnišová Potocká,
   Elena/0000-0003-1546-4134
FU Slovak Research and Development Agency [APVV-0846-12]; Slovak Grant
   Agency for Science VEGA [2/0157/16]; Research & Development Operational
   Programme, European Regional Development Fund [26240120001, 26240120025]
FX This work was supported by the Slovak Research and Development Agency
   under the contract No. APVV-0846-12. This publication is also the result
   of the grant from the Slovak Grant Agency for Science VEGA under the
   Project No. 2/0157/16 and of the projects implementation "Centre of
   Excellence on Green Chemistry Methods and Processes (CEGreenI)" under
   Contract No. 26240120001 and " Amplification of the Centre of Excellence
   on Green Chemistry Methods and Processes (CEGreenII)" under Contract No.
   26240120025 supported by the Research & Development Operational
   Programme, European Regional Development Fund.
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NR 26
TC 12
Z9 12
U1 0
U2 40
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1024-2422
EI 1029-2446
J9 BIOCATAL BIOTRANSFOR
JI Biocatal. Biotransform.
PD JAN 2
PY 2019
VL 37
IS 1
BP 18
EP 24
DI 10.1080/10242422.2017.1423060
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA HL7DW
UT WOS:000458899600003
DA 2026-05-27
ER

PT J
AU Liu, S
   Wang, Y
   Xu, P
   Liu, HY
   Chang, YM
   He, JC
   Wang, SW
   Cao, XB
AF Liu, Shuo
   Wang, Yang
   Xu, Peng
   Liu, Haiyan
   Chang, Yumei
   He, Jiancheng
   Wang, Shiwen
   Cao, Xuebin
TI The Protection of Salidroside on Cardiac Function of Repeated Exhaustive
   Rat Via Anti-Oxidative Stress and MAPKs Signal Transduction
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE Anti-oxidative stress; Heart protection; MAPKs Signal transduction;
   Repeated exhaustion; Salidroside
ID EXERCISE
AB The study is to investigate the cardioprotective effect of salidroside against repeated exhaustive injury and explore the potential involvement of anti-oxidative stress and MAPKs signal transduction. In this experiment, we found that salidroside reduced the myocardium ultrastructure injury caused by exhaustive swimming, decreased the contents of mitogen-activated protein kinases (CK), kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) in repeated exhaustive rats significantly, and improved the LVDP, +/- LVdp/dt(max) of repeated exhaustive rats effectively. Furthermore, salidroside also reduced the content of malondialdehyde (MDA) and the phosphorylation degree of N-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38 MARK), increased the content of superoxide dismutase (SOD) and the phosphorylation degree of extra cellular signal-regulated kinase (ERK) of repeated exhaustive rats, so we conclude that salidroside has the protection on the heart against repeated exhaustive injury and the mechanism is related to anti-oxidative stress and MAPKs signal transduction.
   RESUMEN. El proposito de este estudio es investigar el efecto cardioprotector del salidrosido contra lesiones exhaustivas y repetidas y explorar la posible participacion del estres anti-oxidante y transduccion de senales MAPK. En este experiment se encontro que el salidrosido reduce la lesion ultraestructural del miocardio causada por la natacion exhaustiva, disminuye significativamente los contenidos de las protein-quinasas activadas por mitogenos (CK), la isoenzima quinasa (CK-MB) y la lactato deshidrogenasa (LDH) y mejora la LVDP, +/- LVdP/dtmax de ratas sometidas a natacion exhaustiva. Ademas, el salidrosido tambien redujo el contenido de malondialdehfclo (MDA) y el grado de fosforilacion de la quinasa N-terminal (JNK), la protefn-quinasa p38 mitogeno-activada (MARCA p38), aumento el contenido de la superoxido dismutasa (SOD) y el grado de fosforilacion de la quinasa extracelular regulada por serial (ERK) de ratas sometidas a natacion exhaustiva, por lo que concluimos que el salidrosido ejerce una proteccion del corazon contra lesiones exhaustivas repetidas y el mecanismo estaria relacionado con el estres oxidativo y la transduccion de seriales anti-MAPK.
C1 [Liu, Shuo; Wang, Yang; Xu, Peng; Liu, Haiyan; Chang, Yumei; Cao, Xuebin] 252 Hosp PLA, Senior Cardiovasc Dis Res & Treatment Ctr, Dept Cardiol, Baoding 071000, Peoples R China.
   [He, Jiancheng] Shanghai Univ Tradit Med, Sch Basic Med Sci, Shanghai 201203, Peoples R China.
   [Wang, Shiwen] Gen Hosp PLA, Senior Cardiovasc Dis Inst, Beijing 100853, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Chinese People's
   Liberation Army General Hospital
RP Cao, XB (corresponding author), 252 Hosp PLA, Senior Cardiovasc Dis Res & Treatment Ctr, Dept Cardiol, Baoding 071000, Peoples R China.
EM shiwenwang301@163.com; caoxb252@163.com
RI He, Jiancheng/JUF-6036-2023
FU National Natural Science Foundation of the People's Republic of China
   [81173585]; key Project of "twelfth Five-year Plan" for Medical Science
   Development of PLA [BWS11J058]; Research Project of "twelfth Five-year
   Plan" for Medical Science Development of PLA [CWS12J064]
FX This work was supported by the National Natural Science Foundation of
   the People's Republic of China (No. 81173585) and the key Project of
   "twelfth Five-year Plan" for Medical Science Development of PLA
   (BWS11J058), Research Project of "twelfth Five-year Plan" for Medical
   Science Development of PLA (CWS12J064).
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NR 21
TC 8
Z9 9
U1 0
U2 16
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PD FEB
PY 2014
VL 33
IS 1
BP 5
EP 13
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AJ3GT
UT WOS:000337555200001
DA 2026-05-27
ER

PT J
AU Sa, LN
   Wei, XL
   Huang, Q
   Cai, YC
   Lu, DG
   Mei, RH
   Hu, XL
AF Sa, Lina
   Wei, Xiaoli
   Huang, Qian
   Cai, Yanchun
   Lu, Daigang
   Mei, Ruhuan
   Hu, Xiaolan
TI Contribution of salidroside to the relieve of symptom and sign in the
   early acute stage of osteoarthritis in rat model
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Osteoarthritis; Inflammation; Oxidative stress; Nuclear
   factor kappa-B
ID ARTICULAR-CARTILAGE; PAIN; INFLAMMATION; KNEE; PROGRESSION;
   QUANTITATION; METAANALYSIS; MORPHOLOGY; SYNOVITIS; APOPTOSIS
AB Ethnopharmacological relevance: The genus Rhodiola has been used to treat cough, hemoptysis, fever, pain, bruise and other symptoms which are related to injury and inflammation over a thousand years in traditional Tibetan medicine. Salidroside (p-hydroxyphenethyl-beta-D-glucoside) is one of the most potent bioactive ingredients of the genus Rhodiola.
   Aim of study: The present study aimed to explore whether salidroside could alleviate the clinical symptom and sign in the early acute stage of osteoarthritis (OA) in monosodium iodoacetate (MIA) rat model, and its underlying mechanisms.
   Materials and methods: Osteoarthritis (OA) was induced in rat knees by intra-articular injection of MIA; simultaneously salidroside was administered by intravenous injection. Pain behaviors were evaluated by knee-bend test, hind limb weight-bearing asymmetry and hind paw mechanical withdrawal threshold. The joint swelling was determined by the difference of knee joint diameter. Inflammatory exudates in synovial fluid were evaluated by leukocyte counting and protein content. Cytokines, chemokines, reactive oxygen species (ROS) and reactive nitrogen species (RNS) markers were determined by Enzyme-linked immunosorbent assay (ELISA) and colorimetric assay in synovial fluid. Pro-inflammatory gene expressions in synovial tissue were detected by quantitative real time RT-PCR (qRT-PCR). Nuclear factor kappa-B (NF-kappa B) DNA binding assay and western blot were used to determine NF-kappa B activation and ROS marker protein expression in synovial tissue. Glycosaminoglycan (GAG) content in the cartilage was measured by dimethylmethylene blue method. Hematoxylin and eosin (H&E), Safranin O-fast green and a modified Mankin grading system were used to evaluate the histology of articular cartilage.
   Results: Salidroside could alleviate pain and joint swelling in the early acute stage of OA in rat model, reduced the number of leukocytes, total protein content, proinflammatory mediators and ROS/RNS markers in synovial fluid, down regulated the expression of proinflammatory genes in synovium, inhibited the activation of NF- kappa B and oxidative stress response in synovium, promoted the synthesis of cartilage GAG, prevented the loss of proteoglycan and chondrocyte degeneration.
   Conclusions: Salidroside effectively alleviates acute symptom and sign of OA in rat model by its anti-inflammatory and antioxidant affects to inhibit synovial inflammation, which provides a new strategy to prevent the onset and progression of OA.
C1 [Sa, Lina; Cai, Yanchun; Hu, Xiaolan] Zhejiang Univ, Dept Physiol, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Wei, Xiaoli; Mei, Ruhuan] Zhejiang Univ, Med Expt Ctr, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Huang, Qian] Zhejiang Univ, Affifiliated Hosp 1, Res Ctr Clin Pharm, State Key Lab Diag & Treatment Infect Dis,Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Lu, Daigang] Xi An Jiao Tong Univ, Honghui Hosp, Dept Orthopaed Surg, Sch Med, 555 Youyi East Rd, Xian 710054, Shaanxi, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Xi'an
   Jiaotong University
RP Hu, XL (corresponding author), Zhejiang Univ, Dept Physiol, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM huxiaolan@zju.edu.cn
RI xiaoli, wei/OJU-4925-2025
FU National Natural Science Foundation of China, China [81173466,
   81072415]; Natural Science Foundation of Zhejiang Province, China
   [LY15H180005]; Laboratory for Thrombosis and Haemostasis, Department of
   Pathology and Pathophysiology, Zhejiang University School of Medicine,
   Hangzhou, China
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81173466 and 81072415), China; Natural Science
   Foundation of Zhejiang Province (LY15H180005), China. We are grateful
   for the support by the Laboratory for Thrombosis and Haemostasis,
   Department of Pathology and Pathophysiology, Zhejiang University School
   of Medicine, Hangzhou, China.
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NR 63
TC 16
Z9 26
U1 0
U2 46
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD SEP 15
PY 2020
VL 259
AR 112883
DI 10.1016/j.jep.2020.112883
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA LY2HV
UT WOS:000540342100015
PM 32315736
DA 2026-05-27
ER

EF